Zoé Ladieu Arcas Arnaut Moreira (7613-0B52-7843)

Curriculum Vitae

Zoé Ladieu Arcas Arnaut Moreira

Currently pursuing the Phd in Medical Chemistry at the University of Coimbra on Porphyrins: the nexus between broad-spectrum antiviral photodynamic therapy and photosensitive life-support medical devices, supervised by Prof. Mariette Pereira, and co-supervised by Prof. Vanderlei Bagnato and Prof Miguel A.R.B. Castanho. B.Sc. in Medicinal chemistry in 2019 - University of Coimbra - with an average of 15/20. Master's degree Thesis in Medicinal Chemistry on "Development of cationic photosensitizers for photoinactivation of microorganisms" - with an average of 18/20. Awarded the top 3% Best Students Award successively in 2019 and 2020. Selected to participate in two mobility programs: USA (2012-2013) with AFS intercultural programs and Australia (2018) with the AEN-Utrecht Network. 4 articles published in international journals; Presented 5 posters: 1 at the XXVI SPQ encounter in Portugal, 2019; 3 poster presentation at the International Conference on Porphyrins and Phthalocyanines and 1 poster and 1 Flash communication at the 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry;. Co-inventor in a patent (PPP116946); 8 oral communications 1 at the XXIX European Colloquium on Heterocyclic Chemistry, 1 at the 18th International Photodynamic Association World Congress, 1 at the XXVI Encontro Galego Portugués De Química Congress 1 at the XXVIII Encontro Nacional da SPQ, 1 at the 18th International Congress on Photobiology and 3 at the Portuguese Young Chemists Meeting (Portugal) in 2021 and 2023 as a result of being selected for the final phase of the first and second National SPQ Retrosynthesis Competition. Won the second national retrosynthesis competition of SPQ in 2023. Was awarded 2 merit-based scholarships: 2020 FCT Summer School in Medicinal Chemistry; and Chemistry Research Center 2019. Successfully completed the second modular training in Laboratory Animal Science in 2019. Did an internship at PorphyChem in Dijon, France in 2020 and at the University of Heidelberg, Germany in 2021. Was elected 3 times Chapter Coordinator for AFS Portugal and represented the University of Coimbra for the national university championship of judo (2019).

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Identification

Personal identification

Full name: Zoé Ladieu Arcas Arnaut Moreira

Citation names

Arnaut, Zoe A.

Author identifiers

Ciência ID: 7613-0B52-7843
ORCID iD: 0000-0002-2364-295X

Websites

https://www.uc.pt/fctuc/dquimica/Investigacao/CQC/Linha_D/team/CFCL (Scholar)

Knowledge fields

Exact Sciences - Chemical Sciences - Organic Chemistry
Exact Sciences - Computer and Information Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
French (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2021/11/01 - 2025/11/01 Ongoing	Química (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/10/05 - 2021/07/23 Concluded	Química Medicinal (Mestrado) Universidade de Coimbra, Portugal "Development of cationic photosensitizers for photoinactivation of microorganisms" (THESIS/DISSERTATION)	18
2016/09/16 - 2019/07/23 Concluded	Química Medicinal (Licenciatura) Universidade de Coimbra, Portugal "Design e síntese de sintões para desenvolvimento de compostos com potencial atividade antimicrobiana para a girase B" (THESIS/DISSERTATION)	15,24
2019/01/07 - 2019/01/19 Attended	II Modular Training in Laboratory Animal Science (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	16.8
2018/07/28 - 2018/11/15 Attended	Medicinal Chemistry (Licenciatura) University of Wollongong, Australia
2012/08/18 - 2013/06/28 Attended	Intercultura AFS (Ensino secundário) South Mecklenburg High School, United States

Affiliation

Science

	Category Host institution	Employer
2021/10/01 - 2021/10/31	Research Trainee (Research)	Ruprecht Karls Universitat Heidelberg Fakultät für Chemie und Geowissenschaften, Germany
	Ruprecht Karls Universitat Heidelberg Fakultät für Chemie und Geowissenschaften, Germany
2020/09/01 - 2020/10/31	Research Trainee (Research)	PorphyChem, France
	PorphyChem, France
2020/08/06 - 2020/10/31	Researcher (Research)	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal
2019/10/01 - 2019/12/31	Researcher (Research)	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal

Projects

Other

	Designation	Funders
2021/10/01 - 2021/10/31	Anchorage of homogeneous gold complexes on solid supports for catalytic applications Bilateral action Portugal-Germany Master Student Fellow

Outputs

Publications

Conference abstract	Arnaut, Zoe A.; Lígia C. Gomes-da-silva; Pinto, Sara M. A.; Arnaut, Luis G.; Pereira, Mariette M.. "What makes the strength of very phototoxic photosensitizers". Paper presented in 18th International Congress on Photobiology 2024, Perth, 2024. Published Arnaut, Zoe A.; Cruz-Oliveira, Christine; Cruz-Oliveira, C.; Oliveira, C. C.; Castanho, Miguel; Pereira, Mariette M.. "Synthesis and evaluation of tetrapyrrolic macrocycles as potential antivirals". Paper presented in XXVIII Encontro Nacional da SPQ, Aveiro, 2023. Accepted Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Amorim, Anita; Lobo, Ana Catarina S. ; Pereira, Mariette M.; Arnaut, Luis G.. "Photoinactivation of SARS-CoV-2 using a cationic di-imidazolyl chlorin photosensitizer". Paper presented in 18th International Photodynamic Association World Congress, Tampere, 2023. Published Arnaut, Zoe A.; Felgueiras, Alexandre P.; Stein, Philipp M.; Rudolph, Matthias; Carabineiro, S.A.C.; Carrilho, Rui M. B.; Hashmi, A. Stephen K.; Pereira, Mariette M.. "Gold Tris-BINOL Menthol Monophosphite For The Preparation Of Phenol Derivatives". Paper presented in 8th Portuguese Young Chemistry Meeting, Vila Real, 2023. Published Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana Catarina S. ; Amorim, Anita; Calvete, Mário J. F. ; Rodrigues-Santos, Paulo; et al. "Synthesis of di-imidazolyl porphyrins and their chlorin derivatives for photoinactivation of bacteria and viruses". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022. Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Nunes, Sandra C. C.; Pais, Alberto A C C; Pereira, Mariette M.. "Design and scale-up of amphiphilic cationic meso-imidazolyl porphyrinbased photosensitizers for development of potential antimicrobial agents". Paper presented in XXIX European Colloquium on Heterocyclic Chemistry, 2021. Published
Conference poster	Arnaut, Zoe A.; Felgueiras, Alexandre P.; Fábio M. S. Rodrigues; Aroso, Rafael T.; Alberto A.C.C. Pais; Pereira, Mariette M.. "Synthesis of various meso-aryl porphyrins using flow chemistry". Paper presented in 13th International Conference on Porphyrins and Phthalocyanines, 2024. Arnaut, Zoe A.; Cruz-Oliveira, Christine; Cruz-Oliveira, C.; Oliveira, C. C.; Castanho, Miguel A. R. B.; Pereira, Mariette M.. "Structure-activity relationship of functionalized porphyrins for ZIKV inactivation". Paper presented in 13th International Conference on Porphyrins and Phthalocyanines, 2024. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M.; Pereira, Mariette M.. "Scale-up of cationic meso-imidazolyl porphyrin photosensitizers as antimicrobial agents". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022. Arnaut, Zoe A.; Pereira, Mariette M.; Arnaut, Luis G.; Pais, A. A. C. C.; Nunes, Sandra C. C.; Vinagreiro, Carolina; Pinto, Sara M. A.. "Computational design and synthesis of imidazolyl-tetrapyrrolic macrocycles based photosensitizers for photodynamic inactivation of micro-organisms". Paper presented in International Conference on Porphyrins and Phthalocyanines, 2021. Arnaut, Zoé A.; Pereira, Mariette M.; Aroso, Rafael T.; Pinto, Sara M. A.; Guedes, Rita C.. "The quest for new antibiotics: synthesis of potential DNA gyrase inhibitors". Paper presented in XXVI Encontro Nacional da SPQ, 2019.
Journal article	Amorim, Anita; Arnaut, Zoe A.; Ana I. Mata; Pucelik, Barbara; Barzowska, Agata; da Silva, Gabriela J. ; Pereira, Mariette M.; Dabrowski, Janusz; Arnaut, Luis G.. Corresponding author: Arnaut, Luis G.. "Efficient and Selective, In Vitro and In Vivo, Antimicrobial Photodynamic Therapy with a Dicationic Chlorin in Combination with KI". ACS Infectious Diseases Journal (2024): Published Mendonça, Diogo A.; Iris Cadima-Couto; Buga, Carolina C.; Arnaut, Zoe A.; Schaberle, F. A.; Arnaut, Luis G.; Castanho, Miguel A. R. B.; Cruz-Oliveira, Christine; Cruz-Oliveira, C.; Oliveira, C. C.. Corresponding author: Cruz-Oliveira, Christine; Cruz-Oliveira, C.; Oliveira, C. C.. "Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope". Biomedicine & Pharmacotherapy (2024): Published Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Anita S. Amorim; Lobo, Ana Catarina S. ; Schaberle, F. A.; Pereira, Dina; et al. "Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers". Photochem Photobiol Sci (2023): Published Arnaut, Zoé A.; Pereira, Mariette M.; Aroso, Rafael T.; Giusi Piccirillo; Gonzalez, Andreia; Rodrigues, Fábio. "Photodynamic inactivation of influenza virus as a potential alternative for the control of respiratory tract infections". Journal of Photochemistry and Photobiology (2021): Published • 10.1016/j.jpap.2021.100043

Intellectual property

Provisional application for patent

2020. "Small cationic ortho-5,15-di-heteroaryl-chlorin and bacteriochlorin derivatives and their applications in photoinactivation of microorganisms".
Protected

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/05/19	2ª Competição Nacional de Retrossíntese 2023	8th Portuguese Young Chemists Meeting (Portugal)
2021/05/19	1ª Competição Nacional de Retrossíntese 2020	7th Portuguese Young Chemists Meeting (Bragança, Portugal)

Event participation

	Activity description Type of event	Event name Institution / Organization
2020/08/29 - 2020/11/30	The main objective of this course is to allow students to acquire training in the areas of Chemistry / Medicinal Chemistry, namely in the emerging and interconnected techniques of organic synthesis, purification and characterization of compounds through chromatographic and spectroscopic techniques, drug formulation and administration, cell culture in vitro and data treatment and analysis - focused on scientific research and accompanied by an experience of initiation to scientific research in these areas. Workshop	Training course - Experimental Medicinal Chemistry: From Academia to Pharmaceutical Industry Universidade de Coimbra, Portugal
2017/08/13 - 2017/08/18	The theme of the Volunteer Summer Summit 2017 was "Equal Opportunities". Meeting	Volunteer summer summit AFS-USA Inc, United States

Association member

	Society Organization name	Role
2013/09/01 - Current	Intercultura- AFS	Chapter coordinator; Trainer;

Distinctions

Award

2020	3% Best students award Universidade de Coimbra, Portugal
2019	3% Best students award Universidade de Coimbra, Portugal

Other distinction

2020	FCT Verão com ciência scholarship Fundação para a Ciência e a Tecnologia, Portugal
2019	FCT scholarship (CQC SER C3_4) Fundação para a Ciência e a Tecnologia, Portugal