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I graduated in Marine Biology and Fisheries from the University of Algarve in 1992, where I subsequently pursued my PhD in molecular biology from 1994 to 1999, followed by a Post-Doc in fish molecular endocrinology from 2000 to 2002. In 2002, I embarked on a new chapter of my career as an assistant professor at the University of Beira Interior (FCS-UBI), later earning promotion to associate professor in 2011 through international competition. Furthering my academic achievements, I attained the aggregation title in Biomedicine at UBI in 2019. My transition to UBI marked a pivotal moment in my professional journey, entailing active involvement in establishing research laboratories and outfitting temporary facilities, culminating in the design and equipping of the current facilities at the CICS-UBI building, which we relocated to in 2007/2008. During this period, I forged my research niche in biomedical sciences, initially exploring cancer research before redirecting my focus to the choroid plexus (CP), a critical brain barrier, where I have since made significant scientific contributions. Additionally, I have a keen interest in investigating the impact of sex hormone backgrounds on biological processes and the onset of neuronal diseases and cancer, highlighting the importance of tailored therapeutic approaches based on individuals' biological sex. My involvement in research extends beyond project leadership; I have served as principal investigator (PI) on three FCT-funded projects totaling €340,000, as well as participating as a team member in several other projects. Furthermore, I have supervised numerous PhD and Master's students, guiding them to successful thesis completion. Complementing my research endeavors, I have been actively engaged in teaching molecular and cellular biology, anatomy, histology, and physiology to medical and biomedical students, along with oncobiology to Master's students of Biochemistry and Biomedical Sciences. In addition to my academic roles, I have played a significant role in faculty and research center decision-making bodies, including coordinating various research groups and assuming leadership positions within the CICS-UBI research center. Most recently, I have taken on the role of vice-coordinator at CICS-UBI, continuing to contribute to its academic and research excellence.
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Identification

Personal identification

Full name
Cecília Reis Alves SANTOS

Citation names

  • SANTOS, Cecilia R A
  • Santos, C
  • Santos CR

Author identifiers

Ciência ID
761A-7ED2-D68F
ORCID iD
0000-0001-6074-7825

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/01/22
Concluded
 Biomedicina (Título de Agregado)
Universidade da Beira Interior, Portugal
 Aprovado
1999
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Biologia Molecular
Universidade do Algarve, Portugal
"Molecular Biology of Prolactin and Prolactin Receptor in a Marine Teleost: the Sea Bream (sparus Aurata)" (THESIS/DISSERTATION)
1992
Concluded
 Biologia Marinha e Pescas (Licenciatura)
Universidade do Algarve, Portugal
"Identification of fish species by electrophoresis of muscle extracts" (THESIS/DISSERTATION)
 Bom
Affiliation

Science

Category
Host institution 		Employer
2000/01/01 - 2002/09/04 Postdoc (Research) Universidade do Algarve - Campus de Gambelas, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2011/09/20 - Current Associate Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior, Portugal
2002/09/04 - 2010 Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
1994/10/02 - 1999/12/13 PhD student Universidade do Algarve - Campus de Gambelas, Portugal
Projects

Grant

Designation Funders
2023/12/01 - 2024 Clock ABC
FBR_OC2_78
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Ongoing
2022/06/01 - 2023/06/01 Investigation on the role of the glucosensing receptor T1R3 in glioblastoma hallmarks (STARvE)
NA
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
Ongoing
2023/02 - 2023/06 “Gliorganoides” - Development of GB organoids, originated from GB cell lines, for preclinical evaluation of the anti-proliferative effect of lactisole ”
CENTRO-01-0246-FEDER-000044
Principal investigator
Concluded
2016/07 - 2019/06 Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
PTDC/BIM-ONC/ 7121/2014
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2017/04/01 - Current Desafios interdisciplinares em Neurodegeneração (ICON)
CENTRO-01-0145-FEDER-000013
Researcher
Universidade da Beira Interior, Portugal
Ongoing
2010/04 - Current o Microarray based identification of estrogen and androgen responsive genes in rat choroid plexus PTDC/SAU-NMC/114800/2009 )- € 135 632, 00.
PTDC/SAU-NMC/114800/2009
Principal investigator
Universidade da Beira Interior, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - Current Regulation of human and mouse transthyretin levels in liver and choroid plexus by steroid hormones
POCI/SAU-NEU/55380/2004
Principal investigator
Universidade da Beira Interior, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/01/01 - Current Development of a new methodology for assessing fish and larvae nutritional status
POCTI/38703/CVT/2001
Principal investigator
Universidade do Algarve, Portugal
2018/07/01 - 2021/06/30 Suportes modificados com Liquidos Iónicos para a Purificação de pré-miRNAs envolvidos na doença de Alzheimer
PTDC/BII-BBF/29496/2017
Universidade da Beira Interior, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/04/01 - 2019/10/01 Relação entre adenosina e instabilidade cromossomal: uma nova perspetiva para compreender o mecanismo oncogénico em glioblastoma
PTDC/BIM-ONC/7121/2014
Universidade da Beira Interior, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 709 - 2011-2012
PEst-C/SAU/UI0709/2011
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Furtado, André; Costa, Diana; Lemos, Manuel C.; Cavaco, J. Eduardo; Santos, Cecília R.A.; Quintela, Telma. "The impact of biological clock and sex hormones on the risk of disease". In Advances in Protein Chemistry and Structural Biology, 39-81. Elsevier, 2023.
    10.1016/bs.apcsb.2023.03.004
  2. Gonçalves, Isabel; Quintela, Telma; Duarte, Ana Catarina; Hubbard, Peter; Baltazar, Graça; Schwerk, Christian; Belin, Andrea Carmine; Tomás, Joana; Santos, Cecília Reis A.. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". In Blood-Brain Barrier, 205-230. Springer New York, 2019.
    Published • 10.1007/978-1-4939-8946-1_13
  3. SANTOS, Cecilia. "Estrogens and prostate cancer: from biosynthesis to physiological effects Gomes IM, Vaz C, Rodrigues D, Rocha SM, Socorro S, Santos CR, Maia CJ 01/2013; ISBN: ISB_Estrogens and prostate cancer_ from biosynthesis to physiological effeN: 978-1-62808-962-2 I, Chcts". In Estradiol: synthesis, Health Effects and Drug Interactions. 2013.
    Published
  4. A Santos, Cecilia R; Cardoso, Isabel; Goncalves, Isabel. "Key Enzymes and Proteins in Amyloid-Beta Production and Clearance". In Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets. InTech, 2011.
    10.5772/17646
Conference abstract
  1. Almeida-Santos, Duarte; Duarte, Ana Catarina; Gonçalves, Isabel; SANTOS, Cecilia R A. "Are polyamines detected by the trace amine-associated receptor-1 in the human choroid plexus?". Paper presented in XIV CICS-UBI Annual Symposium, Covilhã, 2019.
  2. PASTORINHO, MANUEL; Sousa, A.C.A.; Bastos, V; Vilhena, H; Miranda, S; Pinto, S; Teixeira, JP; et al. "A pilot observational study on pets DNA damage.". Paper presented in Current Opinion in Biotechnology, 2013.
    Published • 10.1016/j.copbio.2013.05.216
Conference paper
  1. Maia, Cláudio J. B.; Vaz, CV; Peres, Carina; SANTOS, Cecilia R A; Socorro, Sílvia. "Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?". 2010.
  2. Santos, C.R.A.; Power, D.M.. "Piscine (Sparus aurata) transthyretin cDNA cloning and characterization". 1998.
    10.1111/j.1749-6632.1998.tb10892.x
Conference poster
  1. Costa-Brito, Ana R.; Quintela, Telma; Isabel Maria Theriaga Mendes Varanda Gonçalves; Duarte, Ana Catarina; Ana Raquel Ferreira da Costa; Furtado, André; José Eduardo Cavaco; Lemos, Manuel C; SANTOS, Cecilia R A. "Secreted frizzled-related protein 2: Another choroid plexus-derived peptide with neurogenic potential". Paper presented in XVII International CICS-UBI Symposium, 2022.
  2. Costa-Brito, Ana R.; Quintela, Telma; Gonçalves, Isabel; Duarte, Ana Catarina; Costa, Ana Raquel; Cavaco, Jose; Lemos, Manuel Carlos; SANTOS, Cecilia R A. "Expression of Prolactin in the Choroid Plexus: An alternative source of Prolactin in the rat Brain". Paper presented in FENS 2020 Virtual Forum, 2020.
  3. Marques, Ricardo; Vaz, CV; Peres, Carina; Gomes, Inês; SANTOS, Cecilia R A; Maia, Cláudio J. B.; Socorro, Sílvia. "Effect of androgens on the expression of Ca2+-binding protein, regucalcin, and Ca2+-channels in MCF-7 cells". Paper presented in 22nd Congress of European Association for Cancer Research - from Basic Research to Personalized Cancer Treatment, 2012.
Journal article
  1. Rafael Mineiro; Tânia Albuquerque; Ana Raquel Neves; Cecília R. A. Santos; Diana Costa; Telma Quintela. "The Role of Biological Rhythms in New Drug Formulations to Cross the Brain Barriers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612541.
    10.3390/ijms241612541
  2. Rafael Mineiro; Cecília Santos; Isabel Gonçalves; Manuel Lemos; José Eduardo B. Cavaco; Telma Quintela. "Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes". Journal of Physiology and Biochemistry (2023): https://doi.org/10.1007/s13105-023-00957-1.
    10.1007/s13105-023-00957-1
  3. André Furtado; Diana Costa; Lemos, Manuel C; J Eduardo Cavaco; SANTOS, Cecilia R A; Quintela, Telma. Corresponding author: Quintela, Telma. "The impact of biological clock and sex hormones on the risk of disease.". Advances in Protein Chemistry and Structural Biology 137 (2023): 39-81. DOI: 10.1016/bs.apcsb.2023.03.004.
    Published
  4. André Furtado; André J. Esgalhado; Ana Catarina Duarte; Ana R. Costa; Ana R. Costa-Brito; Eva Carro; Hiroshi Ishikawa; et al. "Circadian rhythmicity of amyloid-beta-related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model". Journal of Neuroscience Research 101 4 (2023): 524-540. http://dx.doi.org/10.1002/jnr.25164.
    10.1002/jnr.25164
  5. Ana R. Costa; Ana C. Duarte; Ana R. Costa-Brito; Isabel Gonçalves; Cecília R.A. Santos. "Bitter taste signaling in cancer". Life Sciences 315 (2023): 121363-121363. http://dx.doi.org/10.1016/j.lfs.2022.121363.
    10.1016/j.lfs.2022.121363
  6. Ana Raquel Neves; Tânia Albuquerque; Rúben Faria; Ana M. Gonçalves; Cecília Santos; Eric Vivès; Prisca Boisguérin; et al. "Development of WRAP5 Peptide Complexes for Targeted Drug/Gene Co-Delivery toward Glioblastoma Therapy". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14102213.
    10.3390/pharmaceutics14102213
  7. Ana Catarina Duarte; Ana Raquel Costa; Isabel Gonçalves; Telma Quintela; Robert Preissner; Cecília R.A. Santos. "The druggability of bitter taste receptors for the treatment of neurodegenerative disorders". Biochemical Pharmacology 197 (2022): 114915-114915. http://dx.doi.org/10.1016/j.bcp.2022.114915.
    10.1016/j.bcp.2022.114915
  8. André Furtado; Rafael Mineiro; Ana Catarina Duarte; Isabel Gonçalves; Cecília R. Santos; Telma Quintela. "The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23052443.
    10.3390/ijms23052443
  9. Sandra M. Rocha; Inês Sousa; Inês M. Gomes; Patrícia Arinto; Pedro Costa-Pinheiro; Eduarda Coutinho; Cecília R. Santos; et al. "Promoter Demethylation Upregulates STEAP1 Gene Expression in Human Prostate Cancer: In Vitro and In Silico Analysis". Life 11 11 (2021): 1251-1251. https://doi.org/10.3390/life11111251.
    10.3390/life11111251
  10. Ana R. Costa-Brito; Telma Quintela; Isabel Gonçalves; Ana C. Duarte; Ana R. Costa; Fernando A. Arosa; José E. Cavaco; Manuel C. Lemos; Cecília R. A. Santos. "The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02267-9.
    10.1007/s12035-020-02267-9
  11. Almeida-Santos, D.; Duarte, A.C.; Gonçalves, I.; Ferreira, C.L.; Ferrer, I.; Ishikawa, H.; Schwerk, C.; Schroten, H.; Santos, C.R.A.. "Cadaverine and Spermine Elicit Ca2+ Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway". Journal of Molecular Neuroscience 71 3 (2021): 625-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089730089&partnerID=MN8TOARS.
    10.1007/s12031-020-01684-8
  12. Ana C. Duarte; André Furtado; Mariya V. Hrynchak; Ana R. Costa; Daniela Talhada; Isabel Gonçalves; Manuel C. Lemos; Telma Quintela; Cecília R.A. Santos. "Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21186813.
    10.3390/ijms21186813
  13. Duarte, Ana C.; Rosado, Tiago; Costa, Ana R.; Santos, José; Gallardo, Eugénia; Quintela, Telma; Ishikawa, Hiroshi; et al. "The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier". Biochemical Pharmacology (2020): 113953. http://dx.doi.org/10.1016/j.bcp.2020.113953.
    Published • 10.1016/j.bcp.2020.113953
  14. Duarte, Ana C.; Santos, José; Costa, Ana R.; Ferreira, Catarina L.; Tomás, Joana; Quintela, Telma; Ishikawa, Hiroshi; et al. "Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier". Biochemical Pharmacology (2020): 113954. http://dx.doi.org/10.1016/j.bcp.2020.113954.
    Published • 10.1016/j.bcp.2020.113954
  15. Furtado, A.; Astaburuaga, R.; Costa, A.; Duarte, A.C.; Goncalves, I.; Cipolla-Neto, J.; Lemos, M.C.; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer's Disease". Journal of Alzheimer's Disease 77 2 (2020): 795-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091469905&partnerID=MN8TOARS.
    10.3233/JAD-200331
  16. Costa, A.R.; Lança de Oliveira, M.; Cruz, I.; Gonçalves, I.; Cascalheira, J.F.; Santos, C.R.A.. "The Sex Bias of Cancer". Trends in Endocrinology and Metabolism 31 10 (2020): 785-799. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090305110&partnerID=MN8TOARS.
    10.1016/j.tem.2020.07.002
  17. Marcelino, H.; Nogueira, V.C.; Santos, C.R.A.; Quelhas, P.; Carvalho, T.M.A.; Fonseca-Gomes, J.; Tomás, J.; et al. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry 153 4 (2020): 455-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076898793&partnerID=MN8TOARS.
    10.1111/jnc.14937
  18. Talhada, D.; Gonçalves, I.; Gomes, J.C.; Saraiva, M.J.; Santos, C.R.; Ruscher, K.. "Erratum : Transthyretin expression in the postischemic brain (PLoS ONE 14:9 Doi: 10.1371/journal.pone.0221555)". PLoS ONE 15 6 June (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087100324&partnerID=MN8TOARS.
    10.1371/journal.pone.0235527
  19. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2019): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  20. Santos, C.R.A.; Duarte, A.C.; Costa, A.R.; Tomás, J.; Quintela, T.; Gonçalves, I.. "The senses of the choroid plexus". Progress in Neurobiology 182 (2019): 101680. http://dx.doi.org/10.1016/j.pneurobio.2019.101680.
    10.1016/j.pneurobio.2019.101680
  21. Talhada, Daniela; Santos, Cecília Reis Alves; Gonçalves, Isabel; Ruscher, Karsten. "Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke". Frontiers in Neurology 10 (2019): http://dx.doi.org/10.3389/fneur.2019.01103.
    10.3389/fneur.2019.01103
  22. Talhada, Daniela; Gonçalves, Isabel; Reis Santos, Cecília; Ruscher, Karsten. "Transthyretin expression in the postischemic brain". PLOS ONE 14 9 (2019): e0221555. http://dx.doi.org/10.1371/journal.pone.0221555.
    10.1371/journal.pone.0221555
  23. Tomás, Joana; Santos, Cecília R.A.; Duarte, Ana C.; Maltez, Maria; Quintela, Telma; Lemos, Manuel C.; Gonçalves, Isabel. "Bitter taste signaling mediated by Tas2r144 is down-regulated by 17ß-estradiol and progesterone in the rat choroid plexus". Molecular and Cellular Endocrinology 495 (2019): 110521. http://dx.doi.org/10.1016/j.mce.2019.110521.
    10.1016/j.mce.2019.110521
  24. Quintela, Telma; Duarte, Ana Catarina; Gonçalves, Isabel; Furtado, André; Santos, Cecilia. "Circadian oscillation of Aß-related molecules at the blood cerebrospinal fluid barrier". IBRO Reports 6 (2019): S489. http://dx.doi.org/10.1016/j.ibror.2019.07.1534.
    10.1016/j.ibror.2019.07.1534
  25. Talhada, D.; Feiteiro, J.; Costa, A.R.; Talhada, T.; Cairraõ, E.; Wieloch, T.; Englund, E.; et al. "Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke". Acta Neuropathologica Communications 7 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077089425&partnerID=MN8TOARS.
    10.1186/s40478-019-0866-4
  26. Quintela, Telma; Gonçalves, Isabel; Silva, Marco; Duarte, Ana C.; Guedes, Paula; Andrade, Késsia; Freitas, Flávia; et al. "Choroid plexus is an additional source of melatonin in the brain". Journal of Pineal Research 65 4 (2018): e12528. http://dx.doi.org/10.1111/jpi.12528.
    10.1111/jpi.12528
  27. Quintela, T.; Albuquerque, T.; Lundkvist, G.; Carmine Belin, A.; Talhada, D.; Gonçalves, I.; Carro, E.; Santos, C.R.A.. "The choroid plexus harbors a circadian oscillator modulated by estrogens". Chronobiology International 35 2 (2018): 270-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035097479&partnerID=MN8TOARS.
    10.1080/07420528.2017.1400978
  28. Gomes, I.M.; Rocha, S.M.; Gaspar, C.; Alvelos, M.I.; Santos, C.R.; Socorro, S.; Maia, C.J.. "Knockdown of STEAP1 inhibits cell growth and induces apoptosis in LNCaP prostate cancer cells counteracting the effect of androgens". Medical Oncology 35 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042371755&partnerID=MN8TOARS.
    10.1007/s12032-018-1100-0
  29. "The choroid plexus in health and in disease: dialogues into and out of the brain.". Neurobiology of disease (2017): http://europepmc.org/abstract/med/27546055.
    10.1016/j.nbd.2016.08.011
  30. Alves, Victória Cunha; Silva, Joana Figueiro; Gonçalves, Isabel; Santos, Cecília; Ferrer, Isidre; Carro, Eva. "[P1-214]: ANALYSIS OF THE EXPRESSION OF TASTE AND OLFACTORY RECEPTORS IN CHOROID PLEXUS AND ORBITOFRONTAL CORTEX OF ALZHEIMER's DISEASE PATIENTS". Alzheimer's & Dementia 13 7S_Part_6 (2017): P325-P326. http://dx.doi.org/10.1016/j.jalz.2017.06.034.
    Published • 10.1016/j.jalz.2017.06.034
  31. "The choroid plexus as a sex hormone target: Functional implications.". Frontiers in neuroendocrinology (2017): http://europepmc.org/abstract/med/27998697.
    10.1016/j.yfrne.2016.12.002
  32. "Sex Hormone Decline and Amyloid ß Synthesis, Transport and Clearance in the Brain.". Journal of neuroendocrinology (2016): http://europepmc.org/abstract/med/27632792.
    10.1111/jne.12432
  33. A. R. Costa; H. Marcelino; I. Gonçalves; T. Quintela; J. Tomás; A. C. Duarte; A. M. Fonseca; C. R. A. Santos. "Sex Hormones Protect Against Amyloid-ß Induced Oxidative Stress in the Choroid Plexus Cell Line Z310". Journal of Neuroendocrinology 28 9 (2016): http://dx.doi.org/10.1111/jne.12404.
    10.1111/jne.12404
  34. Maia, Cláudio Jorge; Rocha, Sandra Moreira; Socorro, Sílvia; Schmitt, Fernando; Santos, Cecília Reis. "Oligoadenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones". Advances in Modern Oncology Research 2 2 (2016): 97. http://dx.doi.org/10.18282/amor.v2.i1.70.
    10.18282/amor.v2.i1.70
  35. SANTOS, Cecilia. "Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis". Journal of Neuroendocrinology (2016):
    10.1111/jne.12340
  36. Gonçalves, I.; Hubbard, P.C.; Tomás, J.; Quintela, T.; Tavares, G.; Caria, S.; Barreiros, D.; Santos, C.R.A.. "Smelling the cerebrospinal fluid: Olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus". FEBS Journal 283 9 (2016): 1748-1766. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962788147&partnerID=MN8TOARS.
    10.1111/febs.13700
  37. Tomás, J.; Santos, C.R.A.; Quintela, T.; Gonçalves, I.. ""Tasting" the cerebrospinal fluid: Another function of the choroid plexus?". Neuroscience 320 (2016): 160-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260325&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2016.01.057
  38. Quintela, T.; Sousa, C.; Patriarca, F.M.; Gonçalves, I.; Santos, C.R.. "Gender associated circadian oscillations of the clock genes in rat choroid plexus". Brain structure & function 220 3 (2015): 1251-1262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955597645&partnerID=MN8TOARS.
    10.1007/s00429-014-0720-1
  39. Marques, R.; Vaz, C.V.; Maia, C.J.; Gomes, M.; Gama, A.; Alves, G.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis". Experimental Cell Research 330 2 (2015): 325-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919789386&partnerID=MN8TOARS.
    10.1016/j.yexcr.2014.08.007
  40. Gomes, I.M.; Santos, C.R.; Maia, C.J.; SANTOS, Cecilia. "Expression of steap1 and steap1b in prostate cell lines, and the putative regulation of steap1 by post-transcriptional and post-translational mechanisms". Genes and Cancer 5 3-4 (2014): 142-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938556050&partnerID=MN8TOARS.
    10.18632/genesandcancer.13
  41. Quintela, T.; Marcelino, H.; Gonçalves, I.; Patriarca, F.M.; Santos, C.R.A.. "Gene Expression Profiling in the Hippocampus of Orchidectomized Rats". Journal of Molecular Neuroscience 55 1 (2014): 198-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920841664&partnerID=MN8TOARS.
    10.1007/s12031-014-0304-9
  42. Gomes, I.M.; Arinto, P.; Lopes, C.; Santos, C.R.; Maia, C.J.. "STEAP1 is overexpressed in prostate cancer and prostatic intraepithelial neoplasia lesions, and it is positively associated with Gleason score". Urologic Oncology: Seminars and Original Investigations 32 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84890801992&partnerID=MN8TOARS.
    10.1016/j.urolonc.2013.08.028
  43. Martinho, A.; Santos, C.R.; Gonçalves, I.. "A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERß transactivation". Gene 527 2 (2013): 469-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881552032&partnerID=MN8TOARS.
    10.1016/j.gene.2013.06.078
  44. Martinho, A.; Gonçalves, I.; Santos, C.R.. "Glucocorticoids regulate metallothionein-1/2 expression in rat choroid plexus: Effects on apoptosis". Molecular and Cellular Biochemistry 376 1-2 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874282335&partnerID=MN8TOARS.
    10.1007/s11010-012-1547-9
  45. Quintela, T.; Gonçalves, I.; Carreto, L.C.; Santos, M.A.S.; Marcelino, H.; Patriarca, F.M.; Santos, C.R.A.. "Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876025530&partnerID=MN8TOARS.
    10.1371/journal.pone.0060199
  46. Gomes, I.M.; Santos, C.R.; Socorro, S.; Maia, C.J.. "Six transmembrane epithelial antigen of the prostate 1 is down-regulated by sex hormones in prostate cells". Prostate 73 6 (2013): 605-613. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875803548&partnerID=MN8TOARS.
    10.1002/pros.22601
  47. Gomes, I.; Arinto, P.; Santos, C.R.A.; Socorro, S.; Lopes, C.; Maia, C.J.. "179 Regulation of STEAP1 Expression in Prostate by Sex Steroid Hormones". European Journal of Cancer 48 (2012): S43-S44. http://dx.doi.org/10.1016/s0959-8049(12)70878-x.
    10.1016/s0959-8049(12)70878-x
  48. Marques, R.; Vaz, C.V.; Peres, C.G.; Gomes, I.; Santos, C.R.; Maia, C.J.; Socorro, S.. "177 Effect of Androgens on the Expression of Ca2+-binding Protein, Regucalcin, and Ca2+-channels in MCF-7 Cells". European Journal of Cancer 48 (2012): S43. http://dx.doi.org/10.1016/s0959-8049(12)70876-6.
    10.1016/s0959-8049(12)70876-6
  49. Martinho, A.; Gonçalves, I.; Costa, M.; Santos, C.R.. "Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors". Journal of Molecular Neuroscience 48 1 (2012): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857295144&partnerID=MN8TOARS.
    10.1007/s12031-012-9715-7
  50. Gomes, I.M.; Maia, C.J.; Santos, C.R.. "STEAP proteins: From structure to applications in cancer therapy". Molecular Cancer Research 10 5 (2012): 573-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861142181&partnerID=MN8TOARS.
    10.1158/1541-7786.MCR-11-0281
  51. Santos, C.R.A.; Martinho, A.; Quintela, T.; Gonçalves, I.. "Neuroprotective and neuroregenerative properties of metallothioneins". IUBMB Life 64 2 (2012): 126-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855863743&partnerID=MN8TOARS.
    10.1002/iub.585
  52. Quintela, T.; Gonçalves, I.; Martinho, A.; Alves, C.H.; Saraiva, M.J.; Rocha, P.; Santos, C.R.A.. "Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor". Journal of Molecular Neuroscience 44 3 (2011): 152-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=MN8TOARS.
    10.1007/s12031-010-9398-x
  53. Santos, C; Socorro, S; Maia, C. "STEAP1 (Six Transmembrane Epithelial Antigene of the Prostate 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology 14 5 (2011): 482-484.
    Published • 10.4267/2042/44760
  54. Maia, C; Socorro, S; Santos, C. "STEAP2 (six transmembrane epithelial antigen of the prostate 2)". Atlas of Genetics and Cytogenetics in Oncology and Haematology 15 2 (2011): 217-219.
    Published • 10.4267/2042/44970
  55. Gomes, Inês; Santos, Cecília RA; Socorro, Sílvia; Lopes, Carlos; Maia, Cláudio J; Gomes, Inês Margarida Amaral Santos. "STEAP1 expression in prostate cancer and its regulation by androgens". BMC Proceedings 4 S2 (2010): http://dx.doi.org/10.1186/1753-6561-4-s2-p63.
    10.1186/1753-6561-4-s2-p63
  56. Martinho, A.; Gonçalves, I.; Cardoso, I.; Almeida, M.R.; Quintela, T.; Saraiva, M.J.; Santos, C.R.A.. "Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin". FEBS Journal 277 16 (2010): 3427-3436. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2010.07749.x
  57. Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A.. "17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway". Cellular and Molecular Neurobiology 29 4 (2009): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS.
    10.1007/s10571-008-9339-1
  58. Maia, C.; Santos, C.; Schmitt, F.; Socorro, S.. "Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones". Journal of Cellular Biochemistry 107 4 (2009): 667-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650087642&partnerID=MN8TOARS.
    10.1002/jcb.22158
  59. Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A.. "5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway". Brain Research 1229 (2008): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS.
    10.1016/j.brainres.2008.06.095
  60. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
  61. Maia, C.J.B.; Santos, C.R.; Schmitt, F.; Socorro, S.. "Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17ß-estradiol". Molecular and Cellular Biochemistry 311 1-2 (2008): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349096904&partnerID=MN8TOARS.
    10.1007/s11010-007-9697-x
  62. Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "Characterization of oligoadenylate synthetase-1 expression in rat mammary gland and prostate: Effects of 17ß-estradiol on the regulation of OAS1g in both tissues". Molecular and Cellular Biochemistry 314 1-2 (2008): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449097052&partnerID=MN8TOARS.
    10.1007/s11010-008-9771-z
  63. Gonçalves, I.; Quintela, T.; Baltazar, G.; Almeida, M.R.; Saraiva, M.J.M.; Santos, C.R.. "Transthyretin interacts with metallothionein 2". Biochemistry 47 8 (2008): 2244-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749120520&partnerID=MN8TOARS.
    10.1021/bi7016377
  64. Maia, C.J.B.; Socorro, S.; Schmitt, F.; Santos, C.R.A.. "STEAP1 is over-expressed in breast cancer and down-regulated by 17ß-estradiol in MCF-7 cells and in the rat mammary gland". Endocrine 34 1-3 (2008): 108-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-65449116921&partnerID=MN8TOARS.
    10.1007/s12020-008-9113-7
  65. El-Shishtawy, R.M.; Santos, C.R.; Gonçalves, I.; Marcelino, H.; Almeida, P.. "New amino and acetamido monomethine cyanine dyes for the detection of DNA in agarose gels". Bioorganic and Medicinal Chemistry 15 16 (2007): 5537-5542. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250717530&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.05.043
  66. Morgado, I.; Santos, C.R.A.; Jacinto, R.; Power, D.M.. "Regulation of transthyretin by thyroid hormones in fish". General and Comparative Endocrinology 152 2-3 (2007): 189-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250624480&partnerID=MN8TOARS.
    10.1016/j.ygcen.2006.12.017
  67. Santos, C.R.A.; Estêvão; Fuentes, J.; Cardoso, J.C.R.; Fabra, M.; Passos, A.L.; Detmers, F.J.; et al. "Isolation of a novel aquaglyceroporin from a marine teleost (Sparus auratus): Function and tissue distribution". Journal of Experimental Biology 207 7 (2004): 1217-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144355921&partnerID=MN8TOARS.
    10.1242/jeb.00867
  68. Eneqvist, T.; Lundberg, E.; Karlsson, A.; Huang, S.; Santos, C.R.A.; Power, D.M.; Sauer-Eriksson, A.E.. "High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine". Journal of Biological Chemistry 279 25 (2004): 26411-26416. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942741033&partnerID=MN8TOARS.
    10.1074/jbc.M313553200
  69. Cavaco, J.E.B.; Santos, C.R.A.; Ingleton, P.M.; Canario, A.V.M.; Power, D.M.. "Quantification of prolactin (PRL) and PRL receptor messenger RNA in gilthead seabream (Sparus aurata) after treatment with estradiol-17ß". Biology of Reproduction 68 2 (2003): 588-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037307710&partnerID=MN8TOARS.
    10.1095/biolreprod.102.009209
  70. Santos, C.R.A.; Cavaco, J.E.B.; Ingleton, P.M.; Power, D.M.. "Developmental ontogeny of prolactin and prolactin receptor in the sea bream (Sparus aurata)". General and Comparative Endocrinology 132 2 (2003): 304-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038277017&partnerID=MN8TOARS.
    10.1016/S0016-6480(03)00083-2
  71. Santos, C.R.A.; Anjos, L.; Power, D.M.. "Transthyretin in fish: State of the art". Clinical Chemistry and Laboratory Medicine 40 12 (2002): 1244-1249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036915046&partnerID=MN8TOARS.
    10.1515/CCLM.2002.215
  72. Santos, C.R.A.; Ingleton, P.M.; Cavaco, J.E.B.; Kelly, P.A.; Edery, M.; Power, D.M.. "Cloning, characterization, and tissue distribution of prolactin receptor in the sea bream (Sparus aurata)". General and Comparative Endocrinology 121 1 (2001): 32-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035155087&partnerID=MN8TOARS.
    10.1006/gcen.2000.7553
  73. Power, D.M.; Melo, J.; Santos, C.R.A.. "The effect of food deprivation and refeeding on the liver, thyroid hormones and transthyretin in sea bream". Journal of Fish Biology 56 2 (2000): 374-387. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033845242&partnerID=MN8TOARS.
    10.1006/jfbi.1999.1165
  74. Power, D.M.; Elias, N.P.; Richardson, S.J.; Mendes, J.; Soares, C.M.; Santos, C.R.A.. "Evolution of the thyroid hormone-binding protein, transthyretin". General and Comparative Endocrinology 119 3 (2000): 241-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033760484&partnerID=MN8TOARS.
    10.1006/gcen.2000.7520
  75. Santos, C.R.A.; Power, D.M.. "Identification of transthyretin in fish (Sparus aurata): cDNA cloning and characterisation". Endocrinology 140 5 (1999): 2430-2433. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033306810&partnerID=MN8TOARS.
  76. Santos, C.R.A.; Brinca, L.; Ingleton, P.M.; Power, D.M.. "Cloning, expression, and tissue localisation of prolactin in adult sea bream (Sparus aurata)". General and Comparative Endocrinology 114 1 (1999): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032964884&partnerID=MN8TOARS.
    10.1006/gcen.1998.7228
  77. Santos, C.R.A.; Power, D.M.; Kille, P.; Llewellyn, L.; Ramsurn, V.; Wigham, T.; Sweeney, G.E.. "Cloning and sequencing of a full-length sea bream (Sparus aurata) ß- actin cDNA". Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 117 2 (1997): 185-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030852262&partnerID=MN8TOARS.
    10.1016/S0305-0491(96)00328-8
  78. Llewellyn, L.; Ramsurn, V.P.; Sweeney, G.E.; Wigham, T.; Santos, C.R.A.; Power, D.M.. "Cloning and characterisation of a fish aldolase B gene". BBA - Gene Structure and Expression 1263 1 (1995): 75-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029100196&partnerID=MN8TOARS.
    10.1016/0167-4781(95)00096-Y
Thesis / Dissertation
  1. Brito, Ana Raquel Costa. "The Choroid Plexus as a source and target of Prolactin in the brain". PhD, 2023. http://hdl.handle.net/10400.6/13280.
  2. Costa, Ana Raquel Ferreira da. "Taste signalling in glioblastoma". PhD, Universidade da Beira Interior, 2023. http://hdl.handle.net/10400.6/13306.
  3. Lucas, Carolina Alexandra Emídio. "Bloqueio do glucossensor T1R2/T1R3 em linhas celulares de glioblastoma, cancro de mama e cancro colorretal: Efeitos na proliferação celular, apoptose e migração". Master, 2022. http://hdl.handle.net/10400.6/12468.
  4. Duarte, Ana Catarina Abreu. "Characterization of bitter taste receptors expression and function in the human blood-cerebrospinal fluid barrier". PhD, 2021. http://hdl.handle.net/10400.6/11133.
  5. Pinto, Joana Rita Bichinho. "Análise da expressão do OR51E2 no Glioblastoma Multiforme". Master, 2021. http://hdl.handle.net/10400.6/11505.
  6. Oliveira, Mariana Cristina Lança de. "The role of sexual steroid hormones in glioblastoma". Master, 2020. http://hdl.handle.net/10451/51977.
  7. Tomás, Joana Filipa Melfe. "Taste receptors in the Choroid Plexus are functional and regulated by sex hormones". PhD, 2020. http://hdl.handle.net/10400.6/11162.
  8. Talhada, Daniela de Fátima Rua Matos. "The role of transthyretin and thyroid hormones on functional recovery after experimental stroke". PhD, 2020. http://hdl.handle.net/10400.6/10325.
  9. Furtado, André Filipe Lino. "Disruption of the Choroid Plexus Circadian Rhythm’s in Alzheimer’s Disease". Master, 2019. http://hdl.handle.net/10400.6/10165.
  10. Cruz, Inês da Silva Tavares da. "Is there a Role for Sweet Taste Receptors in the Warburg Effect, Angiogenesis and Cell Survival in Glioblastoma?". Master, 2019. http://hdl.handle.net/10400.6/10168.
  11. Rocha, Duarte Nuno de Almeida Santos e Lopes. "Are polyamines detected by the TAAR receptor family in the human Choroid Plexus?". Master, 2018. http://hdl.handle.net/10400.6/9774.
  12. Santos, José Alberto Canário dos. "Análise da expressão e função dos recetores de compostos amargos no plexo coroide". Master, 2018. http://hdl.handle.net/10400.6/9813.
  13. Xistra, Vera Mónica de Almeida. "Construção de um vetor de expressão de Transtirretina". Master, 2016. http://hdl.handle.net/10400.6/6789.
  14. Marques, Ricardo Jorge Fernandes. "Biological evidence of the protective role of regucalcin in breast cancer". PhD, 2016. http://hdl.handle.net/10400.6/4214.
  15. Oliveira, André Pedro. "Regulation of Aß-scavengers in the choroid plexus of Alzheimer´s disease patients.". Master, 2016. http://hdl.handle.net/10400.6/6383.
  16. Afonso, António Brojo. "Efeitos dos estrogénios na regulação dos scavengers do péptido beta-amilóide no plexo coróide". Master, 2015. http://hdl.handle.net/10400.6/5888.
  17. Tavares, Sara Daniela Sousa. "Síntese de Melatonina no Plexo Coróide". Master, 2015. http://hdl.handle.net/10400.6/6101.
  18. Hrynchak, Mariya. "Evaluation of a-beta scavengers expression in rat choroid plexus: effects of circadian rhythm and a-beta levels". Master, 2015. http://hdl.handle.net/10400.6/6062.
  19. Pinto, José Carlos Pereira. "O papel dos disruptores endócrinos na etiopatogenia do AVC". Master, 2015. http://hdl.handle.net/10400.6/5115.
  20. Albuquerque, Tânia Cristina de Oliveira. "Regulação dos genes circadianos Per1 e Per2 pelo estradiol em células epiteliais do Plexo Coróide". Master, 2014. http://hdl.handle.net/10400.6/5695.
  21. Morete, Nádia Patricia Amaral. "Neuroinflammation and neurogenesis in the choroid plexus". Master, 2014. http://hdl.handle.net/10400.6/5594.
  22. Barreiros, Daniela Batista. "Análise eletrofisiológica da via de transdução olfativa no plexo coróide". Master, 2014. http://hdl.handle.net/10400.6/4809.
  23. Neves, Flávio Ramos das. "Restrição de Glucose na Linha Celular do Plexo Coroide de Rato (Células Z310): Efeito na Remoção do Péptido ß-amiloide". Master, 2014. http://hdl.handle.net/10400.6/5595.
  24. Duarte, Ana Catarina Abreu. "Bisphenol A effects in transthyretin and barrier integrity markers in the choroid plexus: implications in amyloid beta catabolism". Master, 2014. http://hdl.handle.net/10400.6/6055.
  25. Caria, Sandra Cristina dos Santos. "O que será que o plexo coroide pode cheirar?". Master, 2014. http://hdl.handle.net/10400.6/5630.
  26. Gomes, Inês Margarida Amaral Santos. "Regulation of STEAP1 gene and its clinical significance in human prostate cancer". PhD, 2014. http://hdl.handle.net/10400.6/4014.
  27. Sousa, Cláudia Marisa Fernandes. "Ritmo circadiano no plexo coroideu: influência das hormonas sexuais". Master, 2013. http://hdl.handle.net/10400.6/3239.
  28. Gomes, Carla Filipa Costa. "Será que a maquinaria de transdução olfativa está presente no intestino?". Master, 2013. http://hdl.handle.net/10400.6/3268.
  29. Costa, Ana Raquel Ferreira da. "Regulação da apoptose por hormonas sexuais no plexo coroide". Master, 2013. http://hdl.handle.net/10400.6/1339.
  30. Martinho, Ana Isabel de Jesus. "Transthyretin and metallothioneins affect amyloid-beta metabolism and are regulated by glucocorticoids in choroid plexus". PhD, 2013. http://hdl.handle.net/10400.6/1947.
  31. Patriarca, Filipa Marina Pinheiro. "Plexo coroideu: local de síntese de hormonas esteróides?". Master, 2012. http://hdl.handle.net/10400.6/1084.
  32. Costelha, Susete. "Expressão de transtirretina no sistema gastrointestinal do murganho". Master, 2011. http://hdl.handle.net/10400.22/699.
  33. Costa, Marta Isabel Nunes. "Efeito do 17-beta-estradiol na expressão da transtirretina e da metalotioneína 1-2 numa linha celular de plexo coroideu de rato". Master, 2011. http://hdl.handle.net/10400.6/3877.
  34. Veloso, Irina Mendes Morgado. "Regulação da expressão da transtirretina pelo cortisol em ratos". Master, 2010. http://hdl.handle.net/10400.6/3051.
  35. Martins, César Fernando de Bessa. "Estudo da expressão da transtirretina (TTR) no cérebro de ratinho". Master, 2008. http://hdl.handle.net/10400.6/2781.
  36. Alves, Celso Henrique Freitas; Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexuses and downregulated by 5?-dihydrotestosterone in male and female mice". Master, 2008. http://hdl.handle.net/10400.6/1057.
    10.1007/s12031-008-9157-4
  37. Santos, Cecília Reis Alves dos. "Molecular biology of prolactin and prolactin receptor in a marine teleost: the sea bream(Sparus aurata)". PhD, 1999. http://hdl.handle.net/10400.1/8605.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/09/26 Chemical sensing at the rat choroid plexus is regulated by sex hormones XXI Congresso of AIEC
Universidade do Algarve (Faro, Portugal)
2015/07/06 The senses of the choroid plexus (2015). 1, Paris, France from July 6th to 9th 11th International Conference on Cerebral Vascular Biology
(Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - 2023 Taste signalling in glioblastoma
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2022 - 2022 Bloqueio do glucossensor T1R2/T1R3 em linhas celulares de glioblastoma, cancro de mama e cancro colorretal: Efeitos na proliferação celular, apoptose e migração
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2016 - 2022 The Choroid Plexus as a source and target of Prolactin in the brain
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2021 - 2021 Análise da expressão do OR51E2 no Glioblastoma Multiforme
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2020 - 2020 Characterization of bitter taste receptors expression and function in the human blood-cerebrospinal fluid barrier
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2020 - 2020 The Role of Sexual Steroid Hormones in Glioblastoma
Supervisor
 Neurociências (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/03/01 - 2020 The effects of thyroid hormones in the postischemic brain
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2019 - 2019 decoding the role of odorant receptors expressed in the choroid plexus
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2019 - 2019 Is there a Role for Sweet Taste Receptors in the Warburg Effect, Angiogenesis and Cell Survival in Glioblastoma?
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2018 - 2018 Are polyamines detected by the TAAR receptor family in the human Choroid Plexus?
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Análise da Expressão e Função dos Recetores de Compostos Amargos No Plexo Coroide: Estudo da Resposta Ao Resveratrol "
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2017 Regulation of Aß-scavengers in the choroid plexus of Alzheimer´s disease patients
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2016 Construção de um vetor de expressão de Transtirretina
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2010/01/01 - 2015/01/10 Biological evidence of the protective role of regucalcin in breast cancer
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2015 - 2015 O Papel dos Disruptores Endócrinos na Etiopatogenia do AVC Uma revisão
Supervisor
 Medicina (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 Efeitos dos estrogénios na regulação dos scavengers do péptido beta-amilóide no plexo coróide
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2015 Evaluation of a-beta scavengers expression in rat choroid plexus: effects of circadian rhythm and a-beta levels
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2010/01/01 - 2014/10/01 Regulation of STEAP1 gene and its clinical significance in human prostate cancer
Co-supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2014 - 2014 Restrição de glucose na linha celular de células epiteliais do plexo coróide de rato (células Z310): Efeito na remoção do péptido beta amilóide (Aß)
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Bisphenol A effects in transthyretin and barrier integrity markers in the choroid plexus: implications in amyloid beta catabolism
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Neuroinflammation and neurogenesis in the choroid plexus
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2014 Análise eletrofisiológica da via de transdução olfativa no plexo coróide
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 Regulação dos genes circadianos Per1 e Per2 pelo estradiol em células epiteliais do plexo coróide
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2013 - 2013 Regulação da apoptose por hormonas sexuais no plexo coróide de ratos: implicações no clearance of amyloide beta
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2013 - 2013 Ritmo circadiano no plexo coróide: Influencia das hormonas sexuais
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2013 - 2013 O que será que o plexo coróide pode cheirar?
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2013 - 2013 Será que a maquinaria olfactiva está presente no intestino?
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2012 - 2012 Plexo coróideu: local de síntese de hormonas esteroides?
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2011 - 2012 Será que o plexo coróide pode cheirar?
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Efeito do 17-ß-estradiol na expressão da transtirretina e da metalotioneína-1/2 numa linha celular de plexo coroideu de rato
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2011 - 2011 Expressão da transtiretina no sistema gastrointestinal do murganho
Co-supervisor
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2010 - 2010 Resposta da transtiretina ao cortisol no fígado e plexo coróideu de ratos: uma abordagem in vitro e in vivo
Supervisor
 Bioqimica (Master)
Universidade da Beira Interior, Portugal
2005 - 2010 Regulação da Transtirretina e Receptores da Ttr em Linhas Celulares de Fígado e Plexo Coróide por Hormonas Esteróides
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2008 - 2009 Estudo da distribuição da transtirretina no cérebro por hibridação in situ e immunohistoquímica
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2007 - 2008 Caracterização do receptor de androgénios no plexo coróideu de ratos: regulação por hormonas esteróides
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2003 - 2008 Novel Genes Differentially Expressed in Breast and Prostate Cancer: Effect of Sex Steroid Hormones
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2007 - 2007 Regulation of Prolactina Synthesis in Rat and Human Mammary Gland and Prostate
Supervisor
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2012 Aging and Alzheimer´s disease: searching for novel molecular cues Sandro Gabriel Ferreira Dá Mesquita (PhD)
Universidade do Minho, Portugal
2012 miRNA-29 bioseparation and target delivery strategies for Alzheimer’s disease Patrícias Alexandra Nunes Pereira (PhD)
Universidade da Beira Interior, Portugal
2011 Modulating factors in transthyretin/amyloid beta interaction Carlos Alexandre Lopes Rodrigues Ribeiro (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 Transthyretin and Thyroid Hormone Transport in Fish and the Effect of Endocrine Disruptors on This Process Isabel Maria Sena Morgado (PhD)
Universidade do Algarve, Portugal
2007 Contribuição para o Estudo da Hi Perplasia do Tecido Tiróideo, em Linguado (solea Senegalensis, Kaup) Paula Cristina Rodrigues de Sousa Ramos (PhD)
2006 Biochemical and Biological Characteristics of Novel Piscine Forms of Parathyroid Hormone and Parathyroid Hormone Related Peptide in Fish: a Proteomic Approach Liliana Isabel Tomé dos Anjos Guerreiro (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Aparelho Digestivo Mestrado integrado em Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2012 - Current Oncobiologia Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2003 - Current Corpo Humano II Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2002 - Current Biologia celular Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2002 - Current Comunicação em Biomedicina Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2014/01/01 - Current Grant reviewer-Cancer Research Wales -Research projects in cancer research Cancer Research Wales
2018/10/18 - 2023/11/30 Member of the review panel for the evaluation of the MSCA post-doctoral fellowships applications-2018 and 2019 European Commission Research Executive Agency
Evaluator
 European Research Executive Agency, Belgium European Commission
2016/07/09 - 2018/10/06 Review panel member, PhD and Post-doctoral fellowships, Foundation for Science and Technology, Lisbon, Portugal
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2018 - 2018 Evaluator Cancer Research Trust New Zealand (Research Project Grant) (2018) - Developing therapeutic strategies to selectively target tumours expressing 133TP53ß
Distinctions

Title

2019 Agregação
Universidade da Beira Interior Centro de Matemática e Aplicações, Portugal