Frederico Mendes e Pena (761D-3F40-32F1)

Curriculum Vitae

Frederico Mendes e Pena

MSc in Biochemistry, by the University of Coimbra. Scientific domain in Molecular and Cell Biology field, with emphasis on gene-editing.

Identification

Personal identification

Full name: Frederico Mendes e Pena

Citation names

Pena, Frederico

Author identifiers

Ciência ID: 761D-3F40-32F1

Telephones

Mobile phone

966822060 (Personal)

Addresses

Rua Beco da Estremeira, nº15, 3080-443, Figueira da Foz, Coimbra, Portugal (Personal)

Websites

https://www.linkedin.com/in/frederico-pena-800367172/ (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2021/10/01 - 2025/10/01 Ongoing	Biologia Experimental e Biomedicina (Doutoramento) Major in Biotecnologia e Saúde Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2018 Concluded	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease." (THESIS/DISSERTATION)	17
2013 - 2016 Concluded	Biologia (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal	13

Affiliation

Science

	Category Host institution	Employer
2018/11/26 - 2019/12/29	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2017/09/11 - 2018/09/11	Research Trainee (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2017/05 - 2017/06	Research Trainee (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

	Category Host institution	Employer
2020/05 - 2021/09/01	Technician	Universidade de Coimbra - Laboratório de Análises Clínicas, Portugal
	Universidade de Coimbra, Portugal

Projects

Contract

	Designation	Funders
2018/11/26 - 2019/12/31	Tackling cancer stem cells: a challenge and an opportunity to advance in anti- cancer therapy CANCEL_STEM, POCI-01-0145-FEDER-016390 Research Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundo Europeu de Desenvolvimento Regional

Outputs

Publications

Conference poster	Matos, C.A.; Pena, Frederico; Conceição, A.; Lopes, S.; Duarte, S.; Miranda, C.; de Almeida, L.P.. "CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". Paper presented in 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), 2019. Matos, C.A.; Conceição, A.; Pena, Frederico; Lopes, S.; Duarte, S.; Miranda, C.; de Almeida, L.P.. "Transcriptional repression of mutant human ATNX3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), 2019. Lopes, Sara; Matos, Carlos; Pena, Frederico; Conceição, André; Lopes, M.; Nobre, Rui; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph disease". Paper presented in 3rd International Ataxia Research Conference (IARC), 2019. Lopes, S.; Matos, C.; Conceição, André; Pena, Frederico; Lopes, M.; Nobre, R.; Nóbrega, C.; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference, 2019.
Newspaper article	Ana M. Cardoso; Catarina M. Morais; Pena, Frederico; Tânia Marante; Pedro P. Cunha; Amália S. Jurado; Maria C. Pedroso de Lima. "Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib", Human Molecular Genetics, 2021, https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab011/6089139?guestAccessKey=dd59c80e-c55c-4bda-8da3-23ae702af8d3.
Thesis / Dissertation	Pena, Frederico. "CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2018.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2020	CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo.	XLX Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (Coimbra)
2019	CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model.	22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) (Washington, D.C, United States)
2019	CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease	International Machado-Joseph Research Disease Conference (Washington, DC., United States)
2019	CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2018	CRISPR-Cas9-mediated pretranscriptional silencing of mutant ataxin-3.	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) (Lisboa, Portugal)