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Identification

Personal identification

Full name
Maria Teresa Albuquerque Santos Faria Pais

Author identifiers

Ciência ID
7713-AC26-7BF3
ORCID iD
0000-0002-8855-4395
Education
Degree Classification
1995 - 2000
Concluded
 Maria Teresa Albuquerque Santos Faria Pais (Doutoramento)
Major in Ciências da Saúde
Universidade do Porto, Portugal
"Interaction between Mycobacterium avium and the apoptotic macrophage" (THESIS/DISSERTATION)
1995/09 - 1996/05
Concluded
 Training (Outros)
Major in Peter Andersen's Laboratory
Statens Serum Institut, Denmark
1993/09 - 1994/07
Concluded
 ERASMUS (Outros)
Universiteit Utrecht, Netherlands
1989 - 1994/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2019/09/01 - Current Contracted Researcher (Research) Fundação Calouste Gulbenkian, Portugal
Instituto Gulbenkian de Ciência, Portugal
2015/05 - 2018/08 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Gulbenkian de Ciência, Portugal
2015/01/01 - 2015/03/31 Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013/05 - 2014/12 Principal Investigator (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2008/05 - 2013/05 Contracted Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2011/10/01 - 2011/12/31 Visiting Researcher (Research) Gladstone Institutes, United States
Gladstone Institutes, United States
2005/06 - 2008/04 Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
2007/05/01 - 2007/06/30 Visiting Researcher (Research) Universität Bern Medizinische Fakultät, Switzerland
2001/04 - 2005/05 Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/02 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
2023 - 2023 Invited Assistant Professor (University Teacher) Instituto Universitário Egas Moniz Escola Superior de Saúde Egas Moniz, Portugal
2013/08 - 2013/10/31 Visiting Professor (University Teacher) Pontifícia Universidade Católica do Rio Grande do Sul, Brazil
2006/03/01 - 2006/06/30 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa, Portugal
2002/10 - 2003/08 Invited Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Others

Category
Host institution 		Employer
2015/02 - 2017/11 Science Writer BioNews Services, United States
2015/03/01 - 2015/04/30 Consultant Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/04/19 - 2009/05/29 Short Term Internship-Bradley Hayman's Laboratory Harvard Medical School, United States
Massachusetts General Hospital - Harvard Medical School Center for Nervous System Repair, United States
2002/07/09 - 2002/07/23 Short Term Internship-Laura Santambrogio's Laboratory Dana-Farber Cancer Institute Center for Neuro-Oncology, United States
Projects

Grant

Designation Funders
2015/05/01 - 2018/12/31 Master regulators of neuroinflammation in parasitic brain infections
NEUINF
Post-doc
Instituto Gulbenkian de Ciência, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2011/07 - 2014/12 Molecular determinants of microglial activation and neuronal dysfunction in in vivo models of Parkinson´s disease
PTDC/SAU-ORG/114083/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2013 European Project on Mendelian Forms of Parkinson's Disease
Grant Agreement HEALTH 2009241791
Researcher
European Commission Seventh Framework Programme for Research and Technological Development Information and Communication Technologies
2005/06 - 2008/06 Role of activated brain macrophages in animal models of neurological diseases
POCI/SAU-NEU/56986/2004
Principal investigator
Fundação para a Ciência e a Tecnologia
1994 - 2002 Secreção de Proteínas em Mycobacterium Avium
2/2.1/BIA/247/94
PhD Student Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999 - 2000 Immunity to Mycobacterium avium: improving the antimycobacterial activity of the macrophage
POCTI/MGI/32629/99
PhD Student Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1994 - 1998 Human antibody repertoires in transgenic mice: generation, developmental regulation and therapeutic application of high affinity human antibodies
BIO4972284
Researcher
Concluded
Outputs

Publications

Book chapter
  1. Pais, Teresa Faria. "Glial Cells". In Compendium of Inflammatory Diseases, 527-537. Springer Basel, 2016.
    10.1007/978-3-7643-8550-7_111
Conference poster
  1. Pais, Teresa Faria; Penha-Gonçalves, Carlos. "An in vitro system to modulate alterations of the brain endothelial barrier induced by Plasmodium blood stage factors". Paper presented in XLIV SPI Annual Meeting, Lisbon, 2018.
  2. Pais, Teresa Faria; Chhatbar Chintan; Kalinke Ulrich; Penha-Gonçalves, Carlos. "Mechanisms of Type I IFN pathogenicity in experimental cerebral malaria". Paper presented in BioMalPar XIII: Biology and Pathology of the Malaria Parasite, 2017.
  3. Pais, Teresa Faria; Chhatbar Chintan; Kalinke Ulrich; Penha-Gonçalves, Carlos. "INFa/ß in experimental cerebral malaria: MDA-5 requirement and involvement of brain endothelial cells". Paper presented in BioMalPar XII: Biology and Pathology of the Malaria Parasite, 2016.
  4. Pais, Teresa Faria; Chhatbar Chintan; Kalinke Ulrich; Penha-Gonçalves, Carlos. "MDA-5-mediating signaling is required for experimental cerebral malaria". Paper presented in XLII Reunião Anual da Sociedade Portuguesa de Imuologia (SPI), 2016.
  5. Penha-Gonçalves, Carlos; Pais, Teresa Faria. "Mechanisms of INFa/ß-secretion during the effector phase of cerebral malaria". Paper presented in Molecular Approaches to Malaria Conference (MAM2016), 2016.
  6. Pais, Teresa Faria; Guerreiro, Patrícia; Coelho, Joana; Lima, Inês; Macedo, Paula; Lopes, Luisa; Outeiro, Tiago. "Role of type I IL-1R in a transgenic mouse model of alpha-synucleinopathies". Paper presented in CSHL conference on Neurodegenerative Diseases: Biology & Therapeutics, 2014.
  7. Pais, Teresa Faria; Miller-Fleming, L.; Marques, Oldriska; Guerreiro, Patrícia; Oliveira, Rita; Outeiro, Tiago. "Sirtuins: a novel link between neuroiflammation and neurodegeneration". Paper presented in 10th European Meeting on Glial Cells in Health and Disease, 2011.
  8. Pais, Teresa Faria; Machado Oliveira, Rita; Marijanovic, Zrinka; Patrícia S, Guerreiro; Oliveira, Ana Osório; Outeiro, Tiago. "Aging and Neurodegeneration: Common Targets, Common Hopes". Paper presented in World Parkinson Congress, 2009.
  9. Pais, Teresa Faria; Guerreiro, Patrícia; Marques, Oldriska; Outeiro, Tiago. "Sirtuins: a link between ageing and microglial cell neurotoxicity". Paper presented in Annual meeting of the Society for Neurosciences, 2009.
  10. Figueiredo, Catarina; Pais, Teresa Faria; Chatterjee, Sukalyan. "Mechanism of quinolinic acid-mediated neuronal cell death". Paper presented in Meeting on programmed cell death, Cold Spring Harbour Laboratory, 2005.
  11. Braz, Maria H; Pais, Teresa Faria; Chatterjee, Sukalyan. "Activation of Microglia in the adult brain by GM-CSF using a tumor mouse model". Paper presented in VII European Meeting on Glial Cell Function in Health and Disease, 2005.
  12. Pais, Teresa Faria; Chatterjee, Sukalyan. "Characterization of brain macrophage cell populations during experimental cerebral malaria". Paper presented in 7th International Congress of Neuroimmunology, 2004.
  13. Pais, Teresa Faria; Chatterjee, Sukalyan. "Characterization of brain macrophage cell populations during experimental cerebral malaria". Paper presented in 12th International Congress of Immunology and 4th Annual Conference of FOCIS, 2004.
  14. Pais, Teresa Faria; Chatterjee, Sukalyan. "Characterization of brain macrophage cell populations during experimental cerebral malaria". Paper presented in 4th Forum of European Neurosciences (FENS), 2004.
  15. Pais, Teresa Faria; Peixoto, Rui; Chatterjee, Sukalyan. "Response of microglia to neuronal cell death". Paper presented in VI European Meeting on Glial Cell Function in Health and Disease, 2003.
  16. Figueiredo, Catarina; Pais, Teresa Faria; Chatterjee, Sukalyan. "Resistance of microglia to quinolinic mediated cell death". Paper presented in VI European Meeting on Glial Cell Function in Health and Disease, 2003.
  17. Pais, Teresa Faria; Appelberg, Rui. "A new anti-M. avium mechanism associated with induction of apoptosis and dependent on macrophage activation and endogenous production of oxygen radicals". Paper presented in Cold Spring Harbor Meetings: “Microbial Pathogenesis and Host Response” and “Programmed cell death, 1999.
  18. Pais, Teresa Faria; Appelberg, Rui. "Picolinic acid, a catabolite of L-tryptophan, induces intra-macrophagic bacteriostasis in Mycobacterium avium". Paper presented in 13th European Immunology Meeting, 1997.
  19. Pais, Teresa Faria; Appelberg, Rui; Andersen, Peter. "Delayed-type hypersensitivity and protection are mediated by the same T cell subset but by cells with different specificities in murine tuberculosis". Paper presented in Third International Conference of Pathogenesis of Mycobacterial Infections, 1996.
Journal article
  1. Duarte, Nádia; Shafi, Abdul Muktadir; Penha-Gonçalves, Carlos; Pais, Teresa Faria. Corresponding author: Pais, Teresa Faria. "Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target". Frontiers in Cell and Developmental Biology 11 (2023): http://dx.doi.org/10.3389/fcell.2023.1249235.
    10.3389/fcell.2023.1249235
  2. Pais, Teresa Faria; Carlos Penha-Gonçalves. Corresponding author: Pais, Teresa Faria. "In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors". Parasitology Research (2023): https://doi.org/10.1007/s00436-023-07782-x.
    10.1007/s00436-023-07782-x
  3. Pais, Teresa Faria; Hajrabibi Ali; Joana Moreira da Silva; Nádia Duarte; Rita Neres; Chintan Chhatbar; Rita C. Acúrcio; et al. Corresponding author: Pais, Teresa Faria. "Brain endothelial STING1 activation by Plasmodium -sequestered heme promotes cerebral malaria via type I IFN response". Proceedings of the National Academy of Sciences (2022): https://doi.org/10.1073/pnas.2206327119.
    10.1073/pnas.2206327119
  4. Gonçalo Garcia; Teresa Faria Pais; Paula Pinto; Gary Dobson; Gordon J. McDougall; Derek Stewart; Cláudia Nunes Santos. "Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties". Antioxidants 9 10 (2020): 970-970. https://doi.org/10.3390/antiox9100970.
    10.3390/antiox9100970
  5. Sa de Almeida, Joana; Vargas, Mariana; Fonseca-Gomes, João; Tanqueiro, Sara Ramalho; Belo, Rita F.; Miranda-Lourenço, Catarina; Sebastião, Ana M.; Diógenes, Maria José; Pais, Teresa Faria. "Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices". Frontiers in Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnins.2020.00614.
    10.3389/fnins.2020.00614
  6. Pais, Teresa F.; Penha-Gonçalves, Carlos. "Brain Endothelium: The “Innate Immunity Response Hypothesis” in Cerebral Malaria Pathogenesis". Frontiers in Immunology 9 (2019): http://dx.doi.org/10.3389/fimmu.2018.03100.
    10.3389/fimmu.2018.03100
  7. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". (2017): http://hdl.handle.net/10400.18/5465.
    10.1371/journal.pbio.2000374
  8. Figueira, I.; Garcia, G.; Pimpão, R.C.; Terrasso, A.P.; Costa, I.; Almeida, A.F.; Tavares, L.; et al. "Polyphenols journey through blood-brain barrier towards neuronal protection". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029279509&partnerID=MN8TOARS.
    10.1038/s41598-017-11512-6
  9. Guerreiro, P.S.; Coelho, J.E.; Sousa-Lima, I.; Macedo, P.; Lopes, L.V.; Outeiro, T.F.; Pais, T.F.. "Mutant A53T a-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine (2016): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982291567&partnerID=MN8TOARS.
    10.1007/s12017-016-8435-5
  10. Quinti, L.; Casale, M.; Moniot, S.; Pais, T.F.; Van Kanegan, M.J.; Kaltenbach, L.S.; Pallos, J.; et al. "SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models". Cell Chemical Biology 23 7 (2016): 849-861. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978757596&partnerID=MN8TOARS.
    10.1016/j.chembiol.2016.05.015
  11. Cardoso, Filipa; Castro, Flávia Raquel Teixeira de; Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; Torrado, Egídio; Silvestre, Ricardo Jorge Leal; Castro, António G.; Saraiva, Margarida; Pais, Teresa F.. Corresponding author: Pais, Teresa F.. "Myeloid Sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". (2015): http://hdl.handle.net/1822/40103.
    10.1371/journal.pone.0131904
  12. Miller-Fleming, L.; Antas, P.; Pais, T.F.; Smalley, J.L.; Giorgini, F.; Outeiro, T.F.. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences of the United States of America 111 19 (2014): 7012-7017. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900475985&partnerID=MN8TOARS.
    10.1073/pnas.1319221111
  13. Fernandes, A.; Miller-Fleming, L.; Pais, T.F.. "Microglia and inflammation: conspiracy, controversy or control?". Cellular and molecular life sciences : CMLS 71 20 (2014): 3969-3985. http://www.scopus.com/inward/record.url?eid=2-s2.0-84909987977&partnerID=MN8TOARS.
    10.1007/s00018-014-1670-8
  14. Pais, T.F.; Szego, É.M.; Marques, O.; Miller-Fleming, L.; Antas, P.; Guerreiro, P.; De Oliveira, R.M.; Kasapoglu, B.; Outeiro, T.F.. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". EMBO Journal 32 19 (2013): 2603-2616. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885173084&partnerID=MN8TOARS.
    10.1038/emboj.2013.200
  15. de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug Targets 11 10 (2010): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&partnerID=MN8TOARS.
  16. Figueiredo, C.; Pais, T.F.; Gomes, J.R.; Chatterjee, S.. "Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2". Journal of Neurochemistry 107 1 (2008): 73-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849168176&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05577.x
  17. Pais, T.F.; Figueiredo, C.; Peixoto, R.; Braz, M.H.; Chatterjee, S.. "Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway". Journal of Neuroinflammation 5 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-54949148770&partnerID=MN8TOARS.
    10.1186/1742-2094-5-43
  18. Chora, Ângelo A.; Fontoura, Paulo; Cunha, Andreia; Pais, Teresa F.; Cardoso, Sílvia; Ho, Peggy P.; Lee, Lowen Y.; et al. "Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation". (2007): http://www.scopus.com/inward/record.url?scp=33846819008&partnerID=8YFLogxK.
    https://doi.org/10.1172/JCI28844
  19. Chora, Â.A.; Fontoura, P.; Cunha, A.; Pais, T.F.; Cardoso, S.; Ho, P.P.; Lee, L.Y.; et al. "Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation". Journal of Clinical Investigation 117 2 (2007): 438-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846819008&partnerID=MN8TOARS.
    10.1172/JCI28844
  20. Pais, T.F.; Chatterjee, S.. "Brain macrophage activation in murine cerebral malaria precedes accumulation of leukocytes and CD8+ T cell proliferation". Journal of Neuroimmunology 163 1-2 (2005): 73-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844416133&partnerID=MN8TOARS.
    10.1016/j.jneuroim.2005.02.009
  21. Pais, T.F.; Appelberg, R.. "Induction of Mycobacterium avium growth restriction and inhibition of phagosome-endosome interactions during macrophage during macrophage activation and apoptosis induction by picolinic acid plus IFN¿". Microbiology 150 5 (2004): 1507-1518. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942627335&partnerID=MN8TOARS.
  22. Instituto de Ciências Biomédicas Abel Salazar. "Blocking the receptor for interleukin 10 improves anti-mycobacterial chemotherapy and vaccination". (2001): 0022-1767.
  23. Silva, R.A.; Pais, T.F.; Appelberg, R.. "Blocking the receptor for IL-10 improves antimycobacterial chemotherapy and vaccination". Journal of Immunology 167 3 (2001): 1535-1541. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035424768&partnerID=MN8TOARS.
  24. Instituto de Ciências Biomédicas Abel Salazar. "Antigen specificity of the T cell response to Mycobacterium avium infection in mice". (2000): 0019-9567.
  25. Appelberg, R.; Leal, I.S.; Pais, T.F.; Pedrosa, J.; Flórido, M.. "Differences in resistance of C57BL/6 and C57BL/10 mice to infection by Mycobacterium avium are independent of gamma interferon". Infection and Immunity 68 1 (2000): 19-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979338&partnerID=MN8TOARS.
  26. Pais, T.F.; Appelberg, R.. "Macrophage control of mycobacterial growth induced by picolinic acid is dependent on host cell apoptosis". Journal of Immunology 164 1 (2000): 389-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033966376&partnerID=MN8TOARS.
  27. Silva, R.A.; Pais, T.F.; Appelberg, R.. "Effects of interleukin-12 in the long-term protection conferred by a Mycobacterium avium subunit vaccine". Scandinavian Journal of Immunology 52 6 (2000): 531-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034528830&partnerID=MN8TOARS.
    10.1046/j.1365-3083.2000.00816.x
  28. Pais, T.F.; Cunha, J.F.; Appelberg, R.. "Antigen specificity of T-cell response to Mycobacterium avium infection in mice". Infection and Immunity 68 8 (2000): 4805-4810. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033943811&partnerID=MN8TOARS.
    10.1128/IAI.68.8.4805-4810.2000
  29. Gomes, M.S.; Flórido, M.; Pais, T.F.; Appelberg, R.. "Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene". Journal of Immunology 162 11 (1999): 6734-6739. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345593709&partnerID=MN8TOARS.
  30. Gomes, M.S.; Florido, M.; Pais, T.F.; Appelberg, R.. "Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene". International Journal of Leprosy and Other Mycobacterial Diseases 67 4 SUPPL. (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-33748282753&partnerID=MN8TOARS.
  31. Silva, R.A.; Pais, T.F.; Appelberg, R.. "Evaluation of IL-12 in immunotherapy and vaccine design in experimental mycobacterium avium infections". Journal of Immunology 161 10 (1998): 5578-5585. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032533852&partnerID=MN8TOARS.
  32. Pais, T.F.; Silva, R.A.; Smedegaard, B.; Appelberg, R.; Andersen, P.. "Analysis of T cells recruited during delayed-type hypersensitivity to purified protein derivative (PPD) versus challenge with tuberculosis infection". Immunology 95 1 (1998): 69-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031657702&partnerID=MN8TOARS.
    10.1046/j.1365-2567.1998.00561.x
Preprint
  1. Teresa F. Pais; Carlos Penha-Gonçalves. "In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors". 2023. https://doi.org/10.21203/rs.3.rs-2447390/v1.
    10.21203/rs.3.rs-2447390/v1
  2. Teresa F. Pais; Hajrabibi Ali; Joana Moreira da Silva; Nádia Duarte; Rita Neres; Chintan Chhatbar; Rita C. Acúrcio; et al. Corresponding author: Carlos Penha-Gonçalves. "Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response". 2022. https://doi.org/10.1101/2022.02.14.480268.
    10.1101/2022.02.14.480268

Other

Other output
  1. Glial Cells. 2015. Teresa Faria Pais. https://doi.org/10.1007%2F978-3-0348-0620-6_111-1.
    10.1007/978-3-0348-0620-6_111-1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 Innate immunity in the brain: how brain endothelial cells contribute to cerebral malaria. External Seminar
Nova Medica School, NOVA University Lisbon. (Lisbon, Portugal)
2022 Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response. Cell Symposia: The Neuro-Immune Axis.
Cell (Lisbon, Portugal)
2018 Cerebral malaria: a vascular inflammatory disease. External Seminar
iBiMED, University of Aveiro (Aveiro, Portugal)
2018 Breaking barriers: the power of the small IGC PhD/Postdoc seminar
Instituto Gulbenkian de Ciência (Oeiras)
2017 Mechanisms of Type I IFN pathogenicity in experimental cerebral malaria XLIII Reunião Anual da Sociedade Portuguesa de Imuologia (SPI)
Sociedade Portuguesa de Imuologia (SPI) (Porto, Portugal)
2016 The deacetylase Sirtuin 2: a key regulator of macrophage function External Seminar
Centro de Ciências da Saúde Universidade Federal do Espírito Santo (Vitória, Brazil)
2014 The deacetylase Sirtuin 2 is a key regulator of microglial function XVIII Congress of the Sociedade Portuguesa de Bioquímica (SPB)
Sociedade Portuguesa de Bioquímica (SPB) (Coimbra, Portugal)
2014 Microglia and Inflammation: conspiracy, controversy or control? External Seminar
IBMC, University of Porto (Porto, Portugal)
2014 Sirtuin 2: a deacetylase that prevents brain inflammation External Seminar
ICVS, University of Braga (Braga, Portugal)
2013 The NAD-dependent deacetlyase Sirtuin 2 is a supressor of microglial activation and brain inflammation 11th World Congress on Inflammation
(Natal, Brazil)
2013 Sirtuina 2: uma nova ligação entre neurodegeneração e neuroinflamação Pós-Graduação em Biologia Celular e Molecular da Pontifícia
(Porto Alegre, Brazil)
2012 Sirtuin 2: a new player in neuroinflammation I NeuroSeS* Annual symposium
Instituto de Medicina Molecular (Lisbon)
2010 When and how do microglial cells start to be deleterious? Workshop: Molecular Mechanisms in Neurodegeneration: From Molecule to Cures
Harvard Medical School (Sines, Portugal)
2009 A flow cytometry approach to study inflammation in the Central Nervous System Course: "Aplications of flow cytometry in biomedical research"
ICVS, University of Braga (Braga)
2008 Glial-neuronal communication in health and disease Lisbon Neuroscience Meeting
(Lisbon, Portugal)
2007 Role of antigen-specificity in the brain recruitment and pathogenicity of CD8+T cells during cerebral malaria XXXIII Reunião Annual da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (Lisbon, Portugal)
2007 Microglia and T cell activation in cerebral malaria. Internal Seminars
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2007 Microglia and T cell activation in cerebral malaria External Seminar
Theodor Kocher Institute (Berne, Switzerland)
2005 Activation of macrophages within the CNS External Seminar
Instituto de Medicina Molecular (Lisbon, Portugal)
2003 Characterization of brain macrophage cell populations in experimental cerebral malaria XXIX Reunião Annual da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (Porto, Portugal)
2002 Response of microglia to necrotic neurons is primed by GM-CSF and unrelated to 70 kDa or gp96 hsp XXVIII Reunião Annual da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (Coimbra, Portugal)
1999 Interacção Mycobacterium avium-macrófago em apoptose VI Forum Farmacêutico, Novas Terapias e Tecnologias Farmacêuticas
(Porto, Portugal)
1998 Anti- Mycobacterium avium activity and apoptosis are induced in macrophages by either picolinic acid or anti-Fas antibodies Keystone symposia: “Opportunistic Infections”
(United States)
1998 Induction of apoptosis and anti- Mycobacterium avium activity in macrophages by picolinic acid and IFN-gamma are blocked by the prostaglandin 15d-PGJ2 XXIV Reunião da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (SPI) (Porto, Portugal)
1998 Mycobacterium avium- macrophage interactions XI Congresso Nacional da Sociedade Portuguesa de Bioquímica
Sociedade Portuguesa de Bioquímica (SPB) (Tomar, Portugal)
1997 Picolinic acid induces concomitant apoptosis in macrophages and anti-Mycobacterium avium activity XXIII Reunião da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (Porto, Portugal)
1996 DTH and ACR in murine tuberculosis: two different phenomena mediated by the same T cell subset but by cells with different specificities XXII Reunião da Sociedade Portuguesa de Imunologia
Sociedade Portuguesa de Imunologia (Curia, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02/15 - Current Development of a human blood-brain barrier to study the role of the brain innate immune response in cerebral malaria.
Supervisor of Marieke Slangewal
 Master in Biomedical Sciences (Master)
Radboud Universiteit, Netherlands
2018/01/01 - Current From diet to neuronal cells: Investigating the effects of circulating (poly)phenol metabolites on Parkinson's disease.
Co-supervisor of Rafael José Monteiro Careccho
 Molecular Biosciences (PhD)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2019/01 - 2020/01 Bolseira NOS Alive Oeiras: "The IFNß's guide to Cerebral Malaria resistance"
Co-supervisor of Joana da Silva
Instituto Gulbenkian de Ciência, Portugal
2018/09 - 2019/12/02 Identification of particles released from Plasmodium-infected red blood cells as triggers of IFNß in experimental cerebral malaria.
Supervisor of Hajrabibi Aguiar Ali
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/05/01 - 2019/06/30 UK College Final Essay: "Is it realistic to eradicate malaria with a vaccine? "
Supervisor of Anja Petric
2017/08 - 2017/09 Summer Internship: "Protocol development for isolation of microvesicles derived form Plasmodium berghei-infected erythrocytes"
Supervisor of Catarina Costa
Instituto Gulbenkian de Ciência, Portugal
2015 - 2015 Efeitos da expressão microglial de SIRT2 na LTP
Co-supervisor of Joana Rita Alves Sá de Almeida
 Medicina (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014/05 - 2014/08 Molecular determinants of microglial activation and neuronal dysfunction in in vivo models of Parkinson´s disease (PTDC/SAU-ORG/114083/2009)
Supervisor of Patrícia Guerreiro
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014 - 2014 Projetos de Investigação para Alunos do Gabinte de Apoio à Investigação Científica Tecnológica e Inovação (GAPIC)
Co-supervisor of Mariana Vargas
Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2008 Role of activated brain macrophages in animal models of neurological diseases (POCTI/SAUNEU/ 56986/2004).
Supervisor of Carlos Araújo
Instituto Gulbenkian de Ciência, Portugal
2003 - 2007 Role of neuron-microglia interactions in NMDA receptor mediated cell death
Co-supervisor of Catarina Figueiredo
 Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003 - 2004 Microglia activation by Necrotic Neuron Detergent Resistant Membrane Patches
Co-supervisor of Rui Peixoto
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/01 - 2016/06 Membro do Comité de Organização da XLII Reunião da Sociedade Portuguesa de Imunologia (2016/06/01 - 2016/06/03)
Congress (Member of the Organising Committee)
 Instituto Gulbenkian de Ciência, Portugal
2013/08 - 2013/10 Sirtuínas: da restrição calórica à regulação da neuroinflamação: 15 hours (2013/10/21 - 2013/11/01)
Workshop (President of the Organising Committee)
 Pontifícia Universidade Católica do Rio de Janeiro, Brazil
2006 - 2007 Behaviour Pathologies: Biological Approaches (2007/02/14 - 2007/02/16)
Workshop (Member of the Organising Committee)
 Instituto Gulbenkian de Ciência, Portugal
2005 - 2005 Richard Ransohoff : Chemokines and chemokine receptors: Regulators of inflammation and development in the vertebrate nervous system (2005 - 2005)
Seminar (Other)
 Instituto Gulbenkian de Ciência, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - 2023 European Researchers' Night: Speed dating with general public about animal experimentation. European Researchers' Night.
Centro Champalimaud, Portugal
2022/09/20 - 2022/09/21 ECDC Foresight Workshop on drivers. As an invited participant I contribute do the discussion of how different drivers such as population ageing, migration and travel, climate change and antimicrobial resistance may influence possible futures.
Conference
 ECDC Foresight Workshop on drivers
European Centre for Disease Prevention and Control, Sweden
2022 - 2022 Speed dating with high school students about my research project and career. International Day of Immunology
Instituto Gulbenkian de Ciência, Portugal
2017 - 2018 I explained my activities to undergraduate students as I carried them out.
Other
 Job Shadowing - Scientist for a Day
Instituto Gulbenkian de Ciência, Portugal
2017 - 2017 Conversation with the students about my research and career.
Other
 IGC Open DAY Universities
Instituto Gulbenkian de Ciência, Portugal
2016 - 2016 International Day of Immunology: short talk about brain inflammation. International Day of Immunology
Instituto Gulbenkian de Ciência, Portugal
2011 - 2011 Laboratory Animal Science: theoretical classes, 21 h
Other
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009 - 2009 Effective Writing for Grant Proposals
Workshop
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2007/03 - 2007/03 IGC practical courses on rodents: 20 hours
Workshop
Instituto Gulbenkian de Ciência, Portugal
2006/01 - 2006/01 Nervous System and Immune System: a Struggle and a Dialogue: one week course
Workshop
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005/08 - 2005/08 Pathogenesis of neuroimmunologic diseases: two weeks course
Other
Howard Hughes Medical Institute - Marine Biological Laboratory, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021 The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation.
(Thesis) Main arguer
 Mafalda Ferreira Manso (Master)
Universidade de Lisboa, Portugal
2021 Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer’s disease.
(Thesis) Main arguer
 Tiago Rodrigo da Costa Coelho (Master)
Universidade Nova de Lisboa, Portugal
2019 Asymmetric post-translational modifications regulate the intracelular distribution of unstimulated STAT3 dimers
(Thesis) Main arguer
 Beatriz Joana Marques Cardoso (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Contribution of different cellular subsets to the Adenosine A2A Receptor overexpresseion in the rat brain
(Thesis) Main arguer
 Ana Inês Marques Morgado (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 Development of new cellular models for step-by-step analysis of Astrogliogenic pathways
(Thesis) Main arguer
 Ana Catarina Maia Rocha (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Glia-Motoneuron dialogue in ALS onset and progression in G93ASOD1-mice model
(Thesis) Main arguer
 Catarina de Pais Paiva Santos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Digested raspberries polyphenols for brain health: attenuation of neuroinflammation
(Thesis) Main arguer
 Gonçalo Filipe Rodrigues Garcia (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Regulation of IL-10 gene expression in innate immune cells and its impact on inflammatory responses
(Thesis) Main arguer
 Diogo Pinto e Lobo de Jesus Silva (PhD)
Universidade do Minho, Portugal
2012 Deciphering the potential of blackberry polyphenols for Parkinson Disease: digestion, bloof brain barrier transposition and neuroprotective effect
Thesis Member
 Inês Margarida Lourenço Figueira (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010 The microglial response to stimulation with transforming growth factor beta
(Thesis) Main arguer
 Rui Pedro Correia Martins (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 Role of adenosine A2A receptors in the neuroprotective effect of corticotrophin releasing hormone (CRH)
(Thesis) Main arguer
 Jorge Valadas. (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 Patogenicidade das células T CD8+ em modelos experimentais de malária cerebral
(Thesis) Main arguer
 Fernanda Garcia Guedes Baptista (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 Manipulation of T and B Cell Biology Through Transgenic Expression of a Vírus Gene Inhibiting Transcription Via Nf-kb and Nfat
Thesis Member
 Sílvia Cristina de Paiva e Almeida (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Member of Thesis Committee of Diogo Carregosa: Microbiota derived metabolites from dietary phenolics and their potential to mitigate neuroinflammation.
Member
 Universidade NOVA de Lisboa NOVA Medical School, Portugal
2017 - 2020 PhD Thesis Committee of João Filipe Fonseca-Gomes: BDNF receptor cleavage: relevance for Alzheimer's Disease pathophysiology.
Member
 Instituto de Medicina Molecular João Lobo Antunes, Portugal

Consulting

Activity description Institution / Organization
2022/09 - Current Proposal for the Evaluation of in vitro anti-inflammatory activity potential of Sea4Us compounds. Sea4Us, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/02 - Current Invited Assitant Professor Immunology (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2020 - 2023 Invited lectures: Cerebral Malaria: the role of type I IFN signaling activation in the brain. MSc in Biochemistry and Biomedicine (Mestrado) Universidade de Lisboa, Portugal
2012 - 2014 Invited lecture: Neuroinflammation. MSc and PhD Neuroscience Program (Doutoramento) Universidade de Lisboa, Portugal
2013/10 - 2013/11 Workshop: "Sirtuínas: da restrição calórica à regulação da neuroinflamação" Graduate Program in Cellular and Molecular Biology Pontifícia Universidade Católica do Rio Grande do Sul, Brazil
2009 - 2013 Invited Lecture: Neuron-microglia interactions. Master in Molecular Genetics and Biomedicine Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/03 - 2011/03 Invited Lecture: Neuroinflammation. Master in Neurochemistry (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2010 Invited Lecture: Why imaging the nervous system in vivo by two-photon excitation microscopy? Master/Doctoral Program in Biopharmaceutical Sciences (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2008 Invited Lecture: When and how microglial cells become deleterious. PhD Program in Health Sciences (Doutoramento) Universidade de Coimbra, Portugal
2006/03 - 2006/06 Invited Assistant Professor Immunology and Biochemistry (Licenciatura) Universidade Católica Portuguesa, Portugal
2005 - 2005 Invited Lecture: Activation of microglia associated to neuropathologies. Graduate Programme in Basics and Applied Biology (GABA) (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002/10 - 2003/08 Invited Assistant Professor Immunology (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
1999 - 1999 Invited Lecture: T cell-dependent aquired immunity. Immunology (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
1997 - 1998 Invited Lectures: Mycobacterial antigens and Apoptosis. Graduate Programme in Basics and Applied Biology (GABA) (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Mentoring / Tutoring

Topic Student name
2011 - 2015 PhD thesis: Neuroexcitability control by adenosine and BDNF at the adult hippocampus Mariana Colino de Oliveira
2012 - 2014 PhD thesis: Deciphering the molecular role of DJ1 in the ethiology of Parkinson's and Huntington's disease Leonor Miller-Fleming
Distinctions

Award

2023 Best Paper Award
Sociedade Portuguesa de Imunologia, Portugal
2018 Research Assistant (CEEC)
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2013 Visiting Professor
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
2011 EMBO Short-term fellowship
2011 Travelling Fellowship
The Company of Biologists, United Kingdom
2007 Short-term fellowship.
European Federation of Immunological Societies, Netherlands
2001 Post-doctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1994 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1993 Undergraduate fellowship, ERASMUS Programme
Ekurhuleni East Technical and Vocational Education and Training College, South Africa