Carina Maranga (7811-C66B-F64C)

Curriculum Vitae

Carina Maranga

Carina Maranga completed the Master in Celular and Molecular Biology with Specialization in Neurobiology in 2016 by Universidade de Coimbra, Faculdade de Ciências e Tecnologia, and obtained the Biomedical Science Bachelor in 2014 from Universidade do Algarve. She attends the PhD in Bioengineering: Cell therapies and Regenerative Medicine by Universidade de Lisboa, Instituto Superior Técnico, since 2018. Carina published 3 articles in journals and 1 book chapter. Her work as author and co-author was presented in over 10 oral presentations and 18 poster presentations in national and international conferences. Carina participated in 8 events as workshops and meetings with Angelman Syndrome patients and also has received 4 awards. As Master student, she worked in an awarded projecto, then she received a Master fellowship and participated in a project from an industry (TEVA pharmaceutics) and now, as PhD Student, is working in a project that won two grants from a national and international foundations. Carina works in the areas of Medical and Health Sciences with emphasis on neurosciences, technologies involving the manipulation of hiPSCs and health-Related Biotechnology. In her curriculum the most frequent terms in the context of scientific and technological output are: hiPSCs; Cerebellar Organoids; Angelman Syndrome; Neuronal differentiation; Mitochondrial function; Huntington's Disease; HD models.

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Identification

Personal identification

Full name: Carina Maranga

Citation names

Maranga, Carina

Author identifiers

Ciência ID: 7811-C66B-F64C
ORCID iD: 0000-0002-0003-4011

Email addresses

carinamaranga@tecnico.ulisboa.pt (Professional)
carinamaranga@medicina.ulisboa.pt (Professional)

Telephones

Telephone

(+351) 21 423 320 (Professional)

Addresses

Avenida Prof. Dr Cavaco Silva Instituto Superior Técnico , 2744-016, Porto Salvo, Oeiras, Portugal (Professional)

Websites

http://scerg.tecnico.ulisboa.pt/cmaranga.html (Scholar)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2018/02/01 - 2022/06/01 Ongoing	Bioengineering: Cell Therapies and Regenerative Medicine (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal "Cerebellar organoids from hiPSCs to model Angelman Syndrome " (THESIS/DISSERTATION)
2014 - 2016/09/13 Concluded	Celular and Molecular Biology - Specialization in Neurobiology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease " (THESIS/DISSERTATION)	17
2014 Concluded	Biomedical Sciences (Licenciatura) Universidade do Algarve, Portugal "Evaluation of oxidative stress in retinal cells from experimental models of diabetes" (THESIS/DISSERTATION)	16

Affiliation

Science

	Category Host institution	Employer
2017/02/01 - 2018/02/01	Researcher (Research)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal

Projects

Grant

	Designation	Funders
2020 - Current	Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs PMJMCD 2019 PhD Student Fellow Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação Amélia de Mello Ongoing

Contract

	Designation	Funders
2015/09 - 2016/09	Evaluation of oxidative stress and mitochondrial dysfunction in animal models and patients of Huntington's disease using Cu(II)-ATSM PET NA Master Student Universidade de Coimbra, Portugal CNC.IBILI, Portugal	Santa Casa da Misericórdia de Lisboa Concluded

Other

	Designation	Funders
2017/03 - 2018/02	Exploring the role of pridopidine on mitochondrial function and dynamics in Huntingtons disease models NA Master Student Fellow	Teva Pharmaceutical Industries Ltd Concluded

Outputs

Publications

Book chapter	Maranga, Carina; Vieira, Adriana; Bekman, Evguenia; Rocha, Teixeira Simão. "iPSCs for modeling Angelman syndrome". In Induced Pluripotent Stem Cells – Novel Concepts. Portugal: Elsevier, 2020. Submitted • 10.2174/9781681081168115010008
Conference paper	Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019. Published Geva, Michal; Naia, Luana; Ly, Phillip; Lopes, Carla; Mota, Sandra; Maranga, Carina; Hayden, Michael R; Rego, Ana Cristina. "Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor". Paper presented in HSG 2019 – Huntington Study Group Annual Meeting, 2019. Published
Conference poster	Maranga, Carina; Raposo, Ana Cláudia; Vieria, Adriana A.; Arez, Maria; Alípio Gomes; Laura Dias; Casanova, Miguel; Bekman, Evguenia P.; da Rocha, Simão Teixeira. "A PERSONALIZED STEM CELL TOOLKIT FOR MODELING HUMAN DISORDERS". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022. Alípio Gomes; Vieira, Adriana; Maranga, Carina; Casanova, Miguel; Laura Steenpass; Cabral, Joaquim; Fernandes, Tiago G.; da Rocha, Simão Teixeira; Bekman, Evguenia P.. "Correction of disease-causing mutation in Angelman syndrome patient derived iPSC line by CRISPR/Cas9". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim; da Rocha, Simão Teixeira; Fernandes, Tiago G.; Bekman, Evguenia P.. "Recapitulating disease features in cerebellar organoids model of Angelman syndrome". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Fernandes, Tiago; Bekman, Evguenia P.. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Paper presented in Vienna Biocenter PhD Symposium 2021 'Building Bridges', 2021. Maranga, Carina; Vieria, Adriana A.; Silva, Teresa P.; Fernandes, Tiago G.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Bekman, Evguenia P.. "Brain-in-a-dish approach for studying Angelman Syndrome". Paper presented in Neuroepigenetics: From Cells to Behaviour and Disease, 2020. Maranga, Carina; Silva, T.P.; Vaz, Sandra H.; Fernandes, Tiago G.; da Rocha, Simão T.; Bekman, Evguenia; Cabral, Joaquim M.S. "hiPSC-derived cerebellar organoids to model Angelman Syndrome". Paper presented in Organoids: Modelling Organ Development and Disease in 3D Culture - Virtual, 2020. Vieira, Adriana A.; Maranga, Carina; Gomes, Ana; Bekman, Evguenia; da Rocha, Simão T.. "Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs". Paper presented in Innovate Competition – AstraZeneca Foundation, 2020. Geva, Michal; Schenkman, Marina; Naia, Luana; Ly, Phillip; Mota, Sandra; Lopes, Carla; Maranga, Carina; Michael, Hayden; Rego, Ana Cristina. "Amelioration of ER stress and restauration of mitochondrial function contribute to the neuroprotective effects of pridopidine in HD neurons". Paper presented in 15th Annual Huntington’s disease Therapeutics Conference, 2020. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T; Fernandes, Tiago G.; Bekman, Evguenia; Cabral, Joaquim M.S. "Cerebellar organoids derived from human pluripotent stem cells to model Angelman Syndrome". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies., 2019. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T; Fernandes, Tiago G.; Bekman, Evguenia; Cabral, Joaquim M.S. "Disease modeling of Angelman Syndrome using hiPSC-derived cerebellar organoids". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019. Naia, Luana; Ly, P; Mota, Sandra I; Maranga, Carina; Lopes, Carla; Geva, M; Hayden, Michael R; Rego, A. Cristina. "Pridopidine preserves mitochondrial morphofunction in in vitro and ex vivo Huntington's models through sigma-1 receptor-dependent decrease in oxidative stress". Paper presented in The 14th International Conference on Alzheimers & Parkinsons Diseases, 2019. Geva, Michal; Naia, Luana; Ly, Phillip; Mota, Sandra; Lopes, Carla; Maranga, Carina; Hayden, Michael R; Rego, Ana Cristina. "Pridopidine rescues multiple mitochondrial functions impaired in human and mice HD models by activation of the Sigma-1 receptor". Paper presented in HSG 2019 – Huntington Study Group Annual Meeting, 2019. Ferreira, Ildete L; Maranga, Carina; Mota, Sandra I; Laço, Mário N; Sereno, José Vitor Oliveira; Abrunhosa, Antero; Hayden, Michael; Castelo-Branco, Miguel; Rego, A. Cristina. "Redox and mitochondrial function switches in striatum and cortex of pre-symptomatic and symptomatic Huntington's Disease mouse model". Paper presented in XIX National Congress of Biochemistry, 2016. Rego, A. Cristina; Maranga, Carina; Ferreira, Ildete L; Laço, Mário N; Mota, Sandra I; Naia, L; Sereno, José Vitor Oliveira; et al. "Redox changes and bioenergetic defects in striatum and and cortex of pre-symptomatic and symptomatic Huntington's Disease mice". Paper presented in Society for Neuroscience 46th annual meeting, 2016. Mota, Sandra I; Laço, Mário N; Rosa, Maura; Maranga, Carina; Ferreira, Ildete L; Rego, A. Cristina. "Age-dependent oxidative stress in presynaptic terminals of a mouse model of Huntington's Disease". Paper presented in 7th ISN Special Neurochemistry Conference, 2016. Maranga, Carina; Rosa, Maura; Laço, Mário N; Mota, Sandra I; Ferreira, Ildete L; Rego, A. Cristina. "Altered oxidative stress-related proteins in Huntington's Disease YAC128 mouse model". Paper presented in XIII CNC Anual Meeting, 2015. Laço, Mário N; Mota, Sandra I; Maranga, Carina; Ferreira, Ildete L; Rego, A. Cristina. "Redox deregulation in Huntington's Disease YAC128 transgenic mouse model is unrelated to mitochondrial dysfunction". Paper presented in XIII CNC Anual Meeting, 2015.
Journal article	Maranga, Carina; Pereira, Carolina; Raposo, Ana Cláudia; Vieira, Adriana; Duarte, Sofia; Bekman, Evguenia P.; Milagre, Inês; da Rocha, Simão Teixeira. "Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13". Stem Cell Research 61 (2022): 102757. http://dx.doi.org/10.1016/j.scr.2022.102757. 10.1016/j.scr.2022.102757 Naia, Luana; Ly, Phillip; Mota, Sandra I; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al. "The Sigma-1 receptor mediates pridopidine rescue of mitochondrial function in Huntington Disease models". Neurotherapeutics (2021): Published Maranga, Carina; Fernandes, Tiago G.; Bekman, Evguenia; Teixeira da Rocha, Simão. "Angelman Syndrome: a journey through the brain". The FEBS Journal (2020): http://dx.doi.org/10.1111/febs.15258. 10.1111/febs.15258
Newsletter article	Maranga, Carina; Vieira, Adriana A.; Bekman, Evguenia; da Rocha, Simão T.. "Ensaios clínicos em Angelman... e em Portugal?", Newsletter trimestral da Angel, 2020, https://mcusercontent.com/c1201a436f7baec28794d7be1/files/85b64f55-3c95-4997-a30f-ceca8eeac0b0/Newsletter_14.pdf.
Thesis / Dissertation	Maranga, Carina Sofia Barradas. "Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease". Master, 2016. http://hdl.handle.net/10316/33621.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/11/23	Brain-in-a-dish approach to model Angelman Syndrome	Pitch Competition- PhD Open Days 2021 (Lisboa, Portugal)
2020/11	Brain-in-a-dish approach for studying Angelman Syndrome	Pitch Competition- Phd Open Days 2020 Instituto Superior Técnico
2020/05	Angelman Syndrome: Clinical trials and Mini-brains	Virtual meeting Angel- Associação Síndrome de Angelman de Portugal (Portugal)
2020/02/05	Pridopidine rescues mitochondrial function in human and mouse Huntingtons disease models through Sigma-1 receptor	50th Meeting of Portuguese Pharmacology Society Portuguese Pharmacology Society (Porto, Portugal)
2019/05/30	Disease modeling of Angelman Syndrome using hiPSC-derived cerebellar organoids	XVI Meeting of the Portuguese Society for Neuroscience Portuguese Society for Neuroscience (Lisboa, Portugal)
2017/03/15	Mitochondrial deregulation in striatum and cortex of pre-symptomatic and symptomatic Huntington's Disease mouse model	SPDMov 2017 - "Care in Parkinson Disease" Portuguese Society of Movement Disorders (SPDMov) (Offir, Portugal)
2016/06/04	Bioenergetic defects in pre-symptomatic and symptomatic stages in Huntington's disease YAC128 mouse model	XXXth Meeting of study group on brain aging and dementia Study group on brain aging and dementia (GEECD) (Lisboa, Portugal)
2016/02/04	Redox deregulation in pre-symptomatic and symptomatic stages of Huntington's Disease	XLVI Annual Meeting of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Porto, Portugal)

Event participation

	Activity description Type of event	Event name Institution / Organization
2022/02/20 - 2022/02/20	Solidarity walk for Angelman Syndrome Other	Walk'in ANGEL 2022 Angel - Associação Síndrome de Angelman de Portugal, Portugal
2021/12/03 - 2021/12/04	The 2021 FAST Global Summit & Gala Conference	Fast forward together Foundation for Angelman Syndrome Therapeutics, United States
2021/09/24 - 2021/11/22	Writing in the Sciences. This course teaches scientists to become more effective writers, using practical examples and exercises. Workshop	Writing in the Sciences course Stanford University Department of Health Research and Policy, United States
2020/12/04 - 2020/12/04	FAST Global Summit & Gala Congress	Virtually Unstoppable Foundation for Angelman Syndrome Therapeutics, United States
2020/11/23 - 2020/11/23	Organoids With]Out[Borders Symposium	Organoids With]Out[Borders Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/02/15 - 2020/02/15	Commemorative event for the international day of Angelman Syndrome with patients and families Meeting	15 de Fevereiro- International day of Angelman Syndrome Angel - Associação Síndrome de Angelman de Portugal, Portugal
2019/04/09 - 2019/04/09	Neuroengineering \| 3rd ed - Decoding Neural Information Workshop	Neuroengineering \| 3rd ed - Decoding Neural Information Universidade do Porto, Portugal
2017/05/24 - 2017/05/24	Author Workshop by Anthony Newman, Senior publisher Elsevier Publishing Campus Workshop	Author Workshop Universidade de Coimbra, Portugal
2017/05/19 - 2017/05/19	How to structure data for statistical analysis? Workshop	How to structure data for statistical analysis? Universidade de Coimbra, Portugal Laboratório de Bioestatística e Informação médica (LBIM), Portugal
2017/04/28 - 2017/04/28	How to choose the most appropriate statistical technique? Workshop	How to choose the most appropriate statistical technique? Universidade de Coimbra, Portugal Laboratório de Bioestatística e Informação médica (LBIM), Portugal

Association member

	Society Organization name	Role
2019 - Current	Portuguese Society of Stem cells and Cell therapies
2019 - Current	Portuguese Society for Neuroscience

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2021/05/10 - 2021/05/10	Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module	Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2020/05/07 - 2020/05/07	Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module	Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado)	Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/05/07 - 2019/05/07	Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module	Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado)	Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Distinctions

Award

2022	Registration Grant - 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies 2022 Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2021	Registration Grant - XVII Meeting of the Portuguese Society for Neuroscience
2020	EMBL Corporate Partnership Programme Registration Fee Waiver European Molecular Biology Organization , Germany
2019	Registration Grant - 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies 2019 Portuguese Society for Stem Cells and Cell Therapies, Portugal