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Sara R. R. Campos is a biochemist working in the Biomolecular Simulation field since 2005. She completed a PhD by Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa in December 2009. She studies electrostatic effects on protein structure and contributes to the development of methods such as constant-pH molecular dynamics. She has published 22 papers in international peer-reviewed journals.
Identificação

Identificação pessoal

Nome completo
Sara Isabel Rodrigues Rasteiro de Campos

Nomes de citação

  • Campos, Sara R. R.

Identificadores de autor

Ciência ID
7917-7555-5CFE
ORCID iD
0000-0003-1020-6830

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
English
Portuguese (Idioma materno)
Formação
Grau Classificação
2006/01/01 - 2009/12/21
Concluded
Doctoral program in chemical and biological sciences (PhD) (Doutoramento)
Especialização em Biochemistry, Biomolecular Simulation
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Study of the effect of pH on the structure and function of peptides and proteins using molecular simulation methods" (TESE/DISSERTAÇÃO)
Approved, unanimously
2000 - 2004
Concluded
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Isolamento de espécies de Legionella a partir de amostras de solos" (TESE/DISSERTAÇÃO)
16
Percurso profissional

Science

Categoria Profissional
Instituição de acolhimento
Empregador
2022/02/01 - 2022/05/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/01/10 - 2022/01/31 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/02/15 - 2018/12/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/01/01 - 2005/12/31 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Others

Categoria Profissional
Instituição de acolhimento
Empregador
2006/01/01 - 2009/12/21 PhD student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Grant

Designação Financiadores
2006/01/01 - 2009/12/31 Study of the effect of pH on the structure and function of peptides and proteins using molecular simulation methods
SFRH/BD/23506/2005
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designação Financiadores
2018/10/01 - 2022/01/31 Modelling pH effects on beta-lactoglobulin using state-of-the-art constant-pH molecular dynamics
PTDC/QUI-OUT/29441/2017
Principal investigator
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/09/01 - 2015/12/31 Increasing the realism of membrane modelling in constant-pH molecular dynamics methods: inclusion of electrochemical gradients and lipid titration
Post-doc Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2014/08/31 Proton transfer and proton pumping in haem-copper oxidases. Methodological developments and their application to unravel the molecular mechanism.
Post-doc Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/07/01 - 2014/02/28 Increasing the realism of membrane modelling in constant-pH molecular dynamics methods: inclusion of electrochemical gradients and lipid titration
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2013/04/01 - 2013/06/30 Understanding structure-activity relationships in peptide dendrimers using a molecular modelling approach
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/15 - 2013/03/31 Study of pH-dependent protein misfolding using state-of-the-art molecular modeling methods
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2006/01/01 - 2007/11/14 Increasing realism in protein modelling: including pH and redox effects into molecular dynamics simulations
Other
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2005/12/31 Increasing realism in protein modelling: including pH and redox effects into molecular dynamics simulations
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
Produções

Publications

Conference poster
  1. Campos, Sara R. R.; Catarina Grazina; Ana S. F. Oliveira; Pedro R. Magalhães; António M. Baptista. "The membrane electrochemical potential in Poisson– Boltzmann/Monte Carlo approaches". Trabalho apresentado em Protein Electrostatics 2018, 2018.
  2. Campos, Sara R. R.; Olga Iranzo; António M. Baptista. "Portraying the protonation behavior of close titrating sites in four peptidic scaffolds using constant- pH MD". Trabalho apresentado em Protein Electrostatics Berlin 2016, 2016.
Journal article
  1. Lucie da Rocha; António M. Baptista; Sara R. R. Campos. "Computational Study of the pH-Dependent Ionic Environment around ß-Lactoglobulin". The Journal of Physical Chemistry B (2022): https://doi.org/10.1021/acs.jpcb.2c03797.
    10.1021/acs.jpcb.2c03797
  2. António M. Baptista; Lucie da Rocha; Sara R. R. Campos. "FixBox: A General Algorithm to Fix Molecular Systems in Periodic Boxes". Journal of Chemical Information and Modeling (2022): https://doi.org/10.1021/acs.jcim.2c00823.
    10.1021/acs.jcim.2c00823
  3. Lucie da Rocha; António M. Baptista; Sara R. R. Campos. "Approach to Study pH-Dependent Protein Association Using Constant-pH Molecular Dynamics: Application to the Dimerization of ß-Lactoglobulin". Journal of Chemical Theory and Computation (2022): https://doi.org/10.1021/acs.jctc.1c01187.
    10.1021/acs.jctc.1c01187
  4. Lousa, Diana; Pinto, Antónia R. T.; Campos, Sara R. R.; Baptista, António M.; Veiga, Ana S.; Castanho, Miguel A. R. B.; Soares, Cláudio M.. "Effect of pH on the influenza fusion peptide properties unveiled by constant-pH molecular dynamics simulations combined with experiment". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-77040-y.
    Published • 10.1038/s41598-020-77040-y
  5. Nicoletta Liguori; Sara R. R. Campos; António M. Baptista; Roberta Croce. "Molecular Anatomy of Plant Photoprotective Switches: The Sensitivity of PsbS to the Environment, Residue by Residue". The Journal of Physical Chemistry Letters (2019): 1737-1742. https://doi.org/10.1021/acs.jpclett.9b00437.
    10.1021/acs.jpclett.9b00437
  6. Pedro B. P. S. Reis; Diogo Vila-Viçosa; Sara R. R. Campos; António M. Baptista; Miguel Machuqueiro. "Role of Counterions in Constant-pH Molecular Dynamics Simulations of PAMAM Dendrimers". ACS Omega 3 2 (2018): 2001-2009. https://doi.org/10.1021%2Facsomega.7b01708.
    Published • 10.1021/acsomega.7b01708
  7. Magalhães, P.R.; Oliveira, A.S.F.; Campos, S.R.R.; Soares, C.M.; Baptista, A.M.. "Effect of a pH Gradient on the Protonation States of Cytochrome c Oxidase: A Continuum Electrostatics Study". Journal of Chemical Information and Modeling 57 2 (2017): 256-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014290827&partnerID=MN8TOARS.
    10.1021/acs.jcim.6b00575
  8. Oliveira, A.S.F.; Campos, S.R.R.; Baptista, A.M.; Soares, C.M.. "Coupling between protonation and conformation in cytochrome c oxidase: Insights from constant-pH MD simulations". Biochimica et Biophysica Acta - Bioenergetics 1857 6 (2016): 759-771. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964689558&partnerID=MN8TOARS.
    10.1016/j.bbabio.2016.03.024
  9. de Barros, D.P.C.; Campos, S.R.R.; Azevedo, A.M.; Baptista, A.M.; Aires-Barros, M.R.. "Predicting protein partition coefficients in aqueous two phase system". Journal of Chromatography A 1470 (2016): 50-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995380022&partnerID=MN8TOARS.
    10.1016/j.chroma.2016.09.072
  10. Campos, S.R.R.; Iranzo, O.; Baptista, A.M.. "Constant-pH MD Simulations Portray the Protonation and Structural Behavior of Four Decapeptides Designed to Coordinate Cu2+". Journal of Physical Chemistry B 120 6 (2016): 1080-1091. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959440690&partnerID=MN8TOARS.
    10.1021/acs.jpcb.5b12052
  11. Conceição, K.; Magalhães, P.R.; Campos, S.R.R.; Domingues, M.M.; Ramu, V.G.; Michalek, M.; Bertani, P.; et al. "The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: Insights of a lipid-mediated mechanism". Amino Acids 48 1 (2016): 307-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955207969&partnerID=MN8TOARS.
    10.1007/s00726-015-2088-9
  12. Filipe, L.C.S.; Campos, S.R.R.; Machuqueiro, M.; Darbre, T.; Baptista, A.M.. "Structuring peptide dendrimers through pH modulation and substrate binding". Journal of Physical Chemistry B 120 38 (2016): 10138-10152. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992322845&partnerID=MN8TOARS.
    10.1021/acs.jpcb.6b05905
  13. Carvalheda, C.A.; Campos, S.R.R.; Baptista, A.M.. "The Effect of Membrane Environment on Surfactant Protein C Stability Studied by Constant-pH Molecular Dynamics". Journal of Chemical Information and Modeling 55 10 (2015): 2206-2217. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945581645&partnerID=MN8TOARS.
    10.1021/acs.jcim.5b00076
  14. Correia, M.; Snabe, T.; Thiagarajan, V.; Petersen, S.B.; Campos, S.R.R.; Baptista, A.M.; Neves-Petersen, M.T.. "Photonic activation of plasminogen induced by low dose UVB". PLoS ONE 10 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922108038&partnerID=MN8TOARS.
    10.1371/journal.pone.0116737
  15. De Barros, D.P.C.; Campos, S.R.R.; Madeira, P.P.; Azevedo, A.M.; Baptista, A.M.; Aires-Barros, M.R.. "Modeling the partitioning of amino acids in aqueous two phase systems". Journal of Chromatography A 1329 (2014): 52-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895141345&partnerID=MN8TOARS.
    10.1016/j.chroma.2013.12.015
  16. Carvalheda, C.A.; Campos, S.R.R.; Machuqueiro, M.; Baptista, A.M.. "Structural effects of ph and deacylation on surfactant protein c in an organic solvent mixture: A constant-pH MD study". Journal of Chemical Information and Modeling 53 11 (2013): 2979-2989. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888621173&partnerID=MN8TOARS.
    10.1021/ci400479c
  17. Damas, J.M.; Filipe, L.C.S.; Campos, S.R.R.; Lousa, D.; Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Predicting the thermodynamics and kinetics of helix formation in a cyclic peptide model". Journal of Chemical Theory and Computation 9 11 (2013): 5148-5157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887835236&partnerID=MN8TOARS.
    10.1021/ct400529k
  18. Mateus, P.; Delgado, R.; Groves, P.; Campos, S.R.R.; Baptista, A.M.; Brandão, P.; Félix, V.. "Water encapsulation in a polyoxapolyaza macrobicyclic compound". Journal of Organic Chemistry 77 16 (2012): 6816-6824. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865230787&partnerID=MN8TOARS.
    10.1021/jo300799s
  19. Vila-Viçosa, D.; Campos, S.R.R.; Baptista, A.M.; MacHuqueiro, M.. "Reversibility of prion misfolding: Insights from constant-PH molecular dynamics simulations". Journal of Physical Chemistry B 116 30 (2012): 8812-8821. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864755277&partnerID=MN8TOARS.
    10.1021/jp3034837
  20. Campos, S.R.R.; MacHuqueiro, M.; Baptista, A.M.. "Constant-pH molecular dynamics simulations reveal a ß-rich form of the human prion protein". Journal of Physical Chemistry B 114 39 (2010): 12692-12700. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957317648&partnerID=MN8TOARS.
    10.1021/jp104753t
  21. MacHuqueiro, M.; Campos, S.R.R.; Soares, C.M.; Baptista, A.M.. "Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations". Journal of Physical Chemistry B 114 35 (2010): 11659-11667. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956326420&partnerID=MN8TOARS.
    10.1021/jp104418g
  22. Campos, S.R.R.; Baptista, A.M.. "Conformational analysis in a multidimensional energy landscape: Study of an arginylglutamate repeat". Journal of Physical Chemistry B 113 49 (2009): 15989-16001. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549167017&partnerID=MN8TOARS.
    10.1021/jp902991u
Atividades

Oral presentation

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/06/26 How does pH affect the distribution of ions around proteins? Protein Electrostatics Conference
(Genoa, Italy)
2023/06/26 Computing the energetics of palmitate-BLG complex using constant-pH molecular dynamics Protein Electrostatics Conference
(Genoa, Italy)
2019/12/20 The effect of proton binding on dimer formation and other structural properties of beta-lactoglobulin: a constant-pH MD study (keynote) EJIBCE - National meeting of young structural computational biology researchers
Faculdade de Ciências da Universidade de Lisboa (Lisbon, Portugal)

Supervision

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019/11 - Atual Modelling pH effects on beta-lactoglobulin using constant-pH molecular dynamics methods
Co-supervisor de Lucie da Rocha
Biochemistry (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/02 - 2018/06 Molecular modeling study of ß-lactoglobulin dimerization: a first step to hypoallergen design for immunotherapy
Co-supervisor de Lucie da Rocha
Biochemistry for Health (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/09 - 2016/10 Study of the effect of electrochemical gradients on the function of cytochrome c oxidase using molecular simulation methods
Co-supervisor de Catarina Grazina
Bioquímica Médica (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2010/09 - 2011/11 Study of pH-dependent misfolding of surfactant protein C using state-of-the-art molecular modelling techniques
Co-supervisor de Catarina Azevedo Carvalheda dos Santos
Biochemistry (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event organisation

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2017/05/27 - 2017/05/27 ITQB Open Day 2017 (2017/05/27 - 2017/05/27)
Other (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/12/21 - 2016/12/21 EJIBCE 2016: National meeting of young structural computational biology researchers (2016/12/21 - 2016/12/21)
Meeting (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/07/08 - 2014/07/11 Protein Electrostatics satellite meeting of EBEC 2014 (2014/07/08 - 2014/07/11)
Meeting (Member of the Organising Committee)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Mentoring / Tutoring

Tópico Nome do aluno
2018/10 - 2019/10 Supervision of post-graduate student Lucie da Rocha
2011/12 - 2014/04 Co-supervision of post-graduate student Catarina Azevedo Carvalheda dos Santos
Distinções

Other distinction

2006 PhD fellowship SFRH/BD/23506/2005
Fundação para a Ciência e a Tecnologia, Portugal