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PhD in Regenerative Medicine and Mechanism of Disease by NOVA University of Lisbon (2021), with studies in therapeutic targets for Diabetic Retinopathy. Currently part of the team of ALFA Score project at the Algarve Biomedical Center (ABC-RI) as a PhD Researcher. Particular interest in Chronic Diseases, Healthy Aging and Preventive Medicine. Supervised 2 MSc students, 3 scientific traineeships and new members of COVID-OP (NMS lab). In my scientific career, I achieved 8 peer-reviewed publications, 4 of them as first author or co-authorship. My publications have a total of 71 citations, with a H-INDEX of 5 (according to Scopus). I had 2 career breaks due to maternity leave (2016 and 2023).
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Identification

Personal identification

Full name
Daniela Filipa Santos

Citation names

  • Santos, Daniela F.

Author identifiers

Ciência ID
7917-DC57-F21B
ORCID iD
0000-0001-6855-1763

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2016/01/25 - 2021/03/26
Concluded
 Mecanismos de Doença e Medicina Regenerativa (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
"Towards a therapy for diabetic retinopathy: RAS and Berries" (THESIS/DISSERTATION)
2014/01/21
Concluded
 Mestrado em Ciências Biomédicas (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Differential regulation of hippocampal neurogenesis by nitric oxide following seizures" (THESIS/DISSERTATION)
 18
2007 - 2011
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2023/02/01 - Current Postdoc (Research) Universidade do Algarve Algarve Biomedical Center Research Institute, Portugal
2023/02/01 - Current Science and Technology Management Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022/04/15 - 2022/12/31 Contracted Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2015/08/01 - 2015/12/31 Researcher (Research) Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2014/05/01 - 2015/06/30 Researcher (Research) Universidade do Algarve, Portugal

Others

Category
Host institution 		Employer
2020/08/01 - 2022/03/31 Técnica de Laboratório - COVID OP Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/01/25 - 2021/03/26 PhD Candidate Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2011/10/01 - 2012/09/30 Lab Manager Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Projects

Grant

Designation Funders
2016/01/01 - 2020/11/30 Towards a therapy for diabetic retinopathy: RAS and Berries
PD/BD/114251/2016
PhD Student Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Concluded
2015 - 2016 Targeting the renin-angiotensin system for the treatment of retinal diseases
EXPL/BIM-MEC/1433/2013
Research Fellow
Concluded

Contract

Designation Funders
2023/02/01 - Current ALFA Score “ALgarve Fit Aging Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável”
ALG-45-2020-41
Post-doc Fellow
Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
Ongoing
2018 - 2021 TARGET - TArgeting diabetic Retinopathy with GEne Therapy
PTDC/BTM-ORG/28121/2017
Researcher
Concluded
2012/01/01 - 2014 Enhancement of endogenous neurogenesis by nitric oxide: identification of s-nitrosylation targets
PTDC/SAU-OSD/0473/2012
Researcher
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Teshima, Akiko; Ferreira, Ines; Coelho, Inês; Santos, Daniela F.; Carli, Fabrizia; Gastaldelli, Amalia; Costa-Silva, Bruno; de Oliveira RM; Macedo, Maria. Corresponding author: Teshima, Akiko. "The Affinity of Gut-Derived Extracellular Vesicles for the Liver and Their Role in Diabetes Pathogenesis". Paper presented in 2nd Portuguese Network on Extracellular Vesicles meeting, Lisbon, 2024.
    Published • N/A
  2. Teshima, Akiko; Ferreira, Ines; Coelho, Inês; Santos, Daniela F.; Torrejon, Estefania; Carli, Fabrizia; Gastaldelli, Amalia; et al. "Intestinal Extracellular Vesicles: A Contribution to the Pathogenesis of Metabolic Associated Steatotic Liver disease". Paper presented in 58th Annual Scientific Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
    Published • N/A
  3. Teshima, Akiko; Ferreira, Ines; Coelho, Inês; Santos, Daniela F.; Torrejon, Estefania; Carli, Fabrizia; Gastaldelli, Amalia; et al. "Vesículas Extracelulares Intestinais: Uma Contribuição para a Patogénese da Diabetes". Paper presented in 20th Portuguese Diabetes Congress, Vilamoura, 2024.
    N/A
Conference poster
  1. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Rajado, Ana Teresa; Nóbrega, Clévio David Rodrigues ; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. Corresponding author: Araújo, Inês Maria. "Oxidative profile of a cohort of young versus aged individuals in the Algarve region". Paper presented in HEAT-NET Frontiers in Neurodegeneration: from bench to bedside, 2024.
  2. Ramos, Mónica; Santos, Daniela F.; Rajado, Ana Teresa; Silva, Nádia; Araújo, Inês Maria; Pedro Castelo-Branco. "Associations between a DNA methylation-based telomere length estimator, the redox state, diet and aging in the Algarve population". Paper presented in IX SPB Clinical Biochemistry Workshop, 2024.
  3. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. "Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  4. Rajado, Ana Teresa; Pestana, Daniel; Silva, Nádia; Apolónio, Joana ; Esteves, Filipa; Brito, David V.C.; Trindade, Marlene; et al. "Algarve fit ageing score project, a multidisciplinary approach to assess healthy ageing status.". Paper presented in EMBO Workshop "Systems biology: Linking chromatin and epigenetics to disease and development, 2023.
  5. Santos, Daniela F.; Diogo B. Bitoque; Raquel L. Sequeira; Brigite Cabrita; Gabriela A. Silva. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress.". Paper presented in ARVO Annual Meeting 2021, 2021.
  6. Brigite Cabrita; Santos, Daniela F.; Diogo Bitoque; Gabriela A. Silva. "Characterization and modulation of the Renin-Angiotensin System: Towards a new therapy for Diabetic Retinopathy.". Paper presented in AstraZeneca Foundation Innovate Competition as part of iMED Conference 2019, 2019.
  7. Santos, Daniela F.; Mariana Pais; Gabriela A. Silva. "Pyrogallol-O-sulfate decreases the expression of pro-angiogenic and pro-inflammatory proteins in Diabetic Retinopathy models.". Paper presented in ARVO Annual Meeting 2019, 2019.
  8. Santos, Daniela F.; Mariana Pais; Claudia N. Santos; Gabriela A. Silva. "Anti-inflammatory potential of (poly)phenols metabolites in Diabetic Retinopathy models". Paper presented in 2nd NMS Symposium on Chronic Diseases and Translational Science 2018, 2018.
  9. Santos, Daniela F.; Mariana Pais; Claudia N. Santos; Gabriela A. Silva. "Therapeutic potential of (poly)phenols metabolites for the outcome of Diabetic Retinopathy". Paper presented in 2nd Conference on Food Bioactives and Health, 2018.
  10. Sónia Simão; Bitoque, Diogo; Santos, Daniela F.; Inês M. Araújo; Gabriela Araújo Silva. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 53rd EASD Annual Meeting, 2017.
  11. Santos, Daniela F.; Cláudia N. Santos; Gabriela Araújo da Silva. "Can Polyphenols metabolites ameliorate the outcome of Diabetic Retinopathy?". Paper presented in 53rd EASD Annual Meeting, 2017.
  12. Santos, Daniela F.; Sónia Simão; Gabriela A. Silva. "Insights on the role of Renin Angiotensin System in diabetic retinopathy". Paper presented in ESGCT and NVGCT Collaborative Congress, 2014.
  13. Bruno P. Carreira; Santos, Daniela F.; Ana I. Santos; Carvalho, Caetana M.; Inês M. Araújo. "Nitric Oxide regulates neurogenesis in the lesioned brain following seizures". Paper presented in International Meeting on Stem Cells for Regenerative Medicine and Drug Screening, 2013.
Journal article
  1. Simão, Sónia; Teixeira, Mariana; Agostinho, Rafaela; Santos, Daniela F.; Rodrigues, Joana; Vitorino, Marta; Araújo, Inês. Corresponding author: Simão, Sónia. "The role of gasotransmitters in adult neurogenesis (In preparation)". (2024):
  2. Santos, Daniela F.; Simão, Sónia; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro; Araújo, Inês M.. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14995.
    Published • 10.1002/1873-3468.14995
  3. Santos, Daniela F.; Pais, Mariana; Santos, Cláudia N.; Silva, Gabriela A.. "Polyphenol Metabolite Pyrogallol-O-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina". International Journal of Molecular Sciences 22 21 (2021): 11402. http://dx.doi.org/10.3390/ijms222111402.
    10.3390/ijms222111402
  4. Araújo, Rute S.; Silva, Maria S.; Santos, Daniela F.; Silva, Gabriela A.. "Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse". Experimental Eye Research 194 (2020): 108027. http://dx.doi.org/10.1016/j.exer.2020.108027.
    Published • 10.1016/j.exer.2020.108027
  5. Santos, Ana Isabel; Lourenço, Ana Sofia; Simão, Sónia; Marques da Silva, Dorinda; Santos, Daniela Filipa; Onofre de Carvalho, Ana Paula; Pereira, Ana Catarina; et al. "Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics". Redox Biology 32 (2020): 101457. http://dx.doi.org/10.1016/j.redox.2020.101457.
    Published • 10.1016/j.redox.2020.101457
  6. Araújo, Rute S.; Santos, Daniela F.; Silva, Gabriela A.. "The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies". Biochimie 155 (2018): 104-108. http://dx.doi.org/10.1016/j.biochi.2018.06.019.
    Published • 10.1016/j.biochi.2018.06.019
  7. Santos, Ana Isabel; Carreira, Bruno Pereira; Izquierdo-Álvarez, Alicia; Ramos, Elena; Lourenço, Ana Sofia; Filipa Santos, Daniela; Morte, Maria Inês; et al. "S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model". Antioxidants & Redox Signaling 28 1 (2018): 15-30. http://dx.doi.org/10.1089/ars.2016.6858.
    Published • 10.1089/ars.2016.6858
  8. Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells". Angiogenesis 20 1 (2016): 175-181. http://dx.doi.org/10.1007/s10456-016-9526-5.
    Published • 10.1007/s10456-016-9526-5
  9. Simão, Sónia; Santos, Daniela F.; Silva, Gabriela A.. "Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells". European Journal of Pharmaceutical Sciences 92 (2016): 22-27. http://dx.doi.org/10.1016/j.ejps.2016.06.019.
    Published • 10.1016/j.ejps.2016.06.019
  10. Carreira, Bruno P.; Santos, Daniela F.; Santos, Ana I.; Carvalho, Caetana M.; Araújo, Inês M.. "Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures". Oxidative Medicine and Cellular Longevity 2015 (2015): 1-14. http://dx.doi.org/10.1155/2015/451512.
    Published • 10.1155/2015/451512
Thesis / Dissertation
  1. "Towards new therapies for Diabetic Retinopathy: RAS and Berries". PhD, Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, 2021.
  2. Santos, Daniela F.. "Differential regulation of hippocampal neurogenesis by nitric oxide following seizures". Master, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2014.
  3. Santos, Daniela F.. "Efeito do monóxido de azoto de origem inflamatória na formação e sobrevivência de novos neurónios no cérebro de murganho após status epilepticus". Degree, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2011.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/17 Towards a new therapy for Diabetic Retinopathy: RAS and berries. Master in Molecular and Microbial Biology, Course Unit Genetic Expression and Pathology
2024/01/26 Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region IX SPB Clinical Biochemistry Workshop
Sociedade Portuguesa de Bioquimica (Faro, Portugal)
2023/06 Gut extracellular vesicles contribute to dyslipidemia in the liver. 2nd meeting of the Portuguese Network on Extracellular Vesicles
(Lisboa, Portugal)
2023/03 As vesículas extracelulares intestinais contribuem para a acumulação de lípidos nos macrófagos hepáticos 19th Annual Meeting of Portuguese Society for Diabetes
Sociedade Portuguesa de Diabetes (Vilamoura, Portugal)
2019/10/18 Identification of new targets of S-nitrosylation in neurogenic signaling by thiol redox proteomics SINAL 2019 meeting
(Olhão, Portugal)
2019/04 Pyrogallol-o-sulfate decreases the expression of pro-angiogenic and pro-inflammatory proteins in Diabetic Retinopathy Pan-American Research Day Meeting as part of ARVO Annual Meeting 2019
(Vancouver, Canada)
2018/10 Characterization of Ins2Akita Mouse as a Model of Diabetic Retinopathy 2nd NMS Symposium on Chronic Diseases and Translational Science 2018
2016 PEDF Ameliorates Diabetic Retinopathy 1st Simposium on Chronic Diseases at CEDOC

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/09 - 2019/12 Characterization and modulation of the Renin-Angiotensin System in Diabetic Retinopathy
Co-supervisor of Brigite Cabrita
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/09 - 2018/09 Can polyphenols’ metabolites ameliorate the outcome of Diabetic Retinopathy?
Co-supervisor of Mariana Pais
 Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/10 - Current Pint of Science Organização de apoios, oradores e logística antes, durante e pós-evento (2024/05/13 - 2024/05/15)
Festival (Member of the Organising Committee)
2024/03 - 2024/05/19 Corrida pela Investigação – Liga Portuguesa Contra o Cancro Núcleo Regional do Sul – Grupo de Apoio de Faro (2024/05/19 - 2024/05/19)
Other (Member of the Organising Committee)
 Liga Portuguesa Contra o Cancro, Portugal
2023/10 - 2023/10 Mama em Movimento 2023 - Corrida Solidária (2023/10 - 2023/10)
Other (Member of the Organising Committee)
 Associac¸a~o para o Desenvolvimento do Centro Acade´mico de Investigac¸a~o e Formac¸a~o Biome´dica do Algarve, Portugal
2023/02/01 - 2023/05/03 FENS Regional Meeting 2023 (2023/05/03 - 2023/05/05)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Algarve Biomedical Center Research Institute, Portugal
2023/05/02 - 2023/05/02 VII Symposium of the Portuguese Glial Network (2023/05/02 - 2023/05/02)
Conference (Member of the Organising Committee)
 Universidade do Algarve Algarve Biomedical Center Research Institute, Portugal
2023/02/01 - 2023/05/02 FENS Glia Annual Meeting (2023/05/02 - 2023/05/02)
Meeting (Member of the Organising Committee)
 Universidade do Algarve Algarve Biomedical Center Research Institute, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/01/31 - Current King's College London Centre for Doctoral Studies/Elsevier Workshop 'How to get published and get your article accepted in a good journal'
Workshop
 Workshop 'How to get published and get your article accepted in a good journal'
King's College London - Waterloo Campus, United Kingdom
2024/09/05 - 2024/09/06 HEAT-NET Frontiers in Neurodegeneration: from bench to bedside – Cádiz, Spain
Conference
 HEAT-NET Frontiers in Neurodegeneration: from bench to bedside
Universidad de Cádiz Facultad de Medicina, Spain
2023/07/03 - 2023/07/06 Hybrid Training School within the scope of COST Action: CA20140 - CorEuStem: The European Network for Stem Cell Core Facilities
Other
 Brain organoids methodologies
Centre de Regulació Genòmica, Spain
2023/01/31 - 2023/01/31 2-hours in-person training about JOVE Platform as a clinical, research and learning tool
Seminar
 JOVE Platform 2-hours in-person training
Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2021/01/12 - 2021/02/02 Formação em Ilustração Científica
Other
Associação Nacional de Ciências Biomédicas, Portugal
2020/04/13 - 2020/04/13 Farmacovigilância – noções gerais
Workshop
2019/11/19 - 2019/11/19 1º Workshop em Biossegurança
Workshop
2019/05 - 2019/05 JAX Lisbon Seminars on Guidelines for Sizing Experimental Mouse Colonies and Efficient Mouse Colony Management
Seminar
2019/03/28 - 2019/03/28 FOOD FOR THOUGHT 2019
Other
2018/12/04 - 2018/12/04 Training session on "Portuguese Legislation on Animal use in Research"
Seminar
Fundação Champalimaud, Portugal
2018/09/24 - 2018/09/24 Charles River & The Jackson Laboratory Seminar 2018
Seminar
2017/11/24 - 2017/11/24 Career Opportunities for PostDoctoral Researchers in Life Sciences
Other
 Career Opportunities for PostDoctoral Researchers in Life Sciences
2016/06/30 - 2016/07/01 1st CEDOC Symposium on chronic diseases
Symposium
2012/02 - 2012/02 Management of Laboratory Waste
Seminar
Carmona, Global Management of Hazardous Waste S.A. , Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2012/02 - 2012/02 Mendeley, bibliographic manager and pdf’s
Workshop
Universidade do Algarve, Portugal
2011/10 - 2011/12 Development of Scientific skills
Workshop
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2011/07 - 2011/07 I Workshop in Human Reproduction
Workshop
Universidade de Aveiro, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/03 - 2021 Membro Representante dos alunos de 3o Ciclo em mesa de Conselho Pedagógico da Nova Medical School - Universidade Nova de Lisboa
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/09 - 2019/12 Blended Learning International Entrepreneurship Experience (BLUES program) Universidade Nova de Lisboa, Portugal
2018/03 - 2018/03 Project Management Course Universidade Nova de Lisboa, Portugal
2017/10 - 2017/10 1st FlxFlow Course - Principles and Applications of Flow Cytometry Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/03 - 2017/03 Biosafety Course Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2016/06/27 - 2016/06/30 Champalimaud Practical Course on Animal Use in Science Sociedade Portuguesa em Ciências de Animais de Laboratório, Portugal

Fundação Champalimaud, Portugal
2016/02/29 - 2016/03/04 Advanced Course in Vision Sciences (25h) Universidade de Coimbra, Portugal
2016 - 2016 Curso Teórico Online de Ciências de Animais de Laboratório, 20h

Mentoring / Tutoring

Topic Student name
2020/01 - 2020/05 Effect of polyphenol-derived metabolites in the retina of diabetic mice model João Henriques
2019/08 - 2019/09 Towards a new therapy for Diabetic Retinopathy: RAS and Berries Maria Beatriz
2016/04 - 2016/05 Towards a Therapy for Diabetic Retinopathy: RAS and berries Maria João Lage Sá da Ponte
2015/10 - 2015/11 Identification of S-nitrosylation targets 2º year of Biomedical Sciences degree
Distinctions

Award

2018 Poster Award
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Other distinction

2016 Prémio Janssen Inovação Honorable Mention