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Vitor Francisco graduated in Chemistry from University of Coimbra in 2008 and completed a PhD degree in Physical Chemistry from the University of Santiago de Compostela (Spain) in 2014 where he contributed to the field of drug delivery using supramolecular chemistry. Since obtaining his PhD degree, he joined the group of Lino Ferreira, ERC and ERA Chair grantee, at Center for Innovative Biomedicine and Biotechnology with a post-doctoral fellowship and then as contracted researcher, where he is currently focusing on controlled delivery of drugs mainly for ageing-related diseases. V. Francisco has published 26 articles in international peer-reviewed journals ranked in the highest quartile (Q1), has 1 patent registered, 1 provisional patent application and 1 under preparation. He is Guest Associate Editor at Frontiers in Chemistry, Reviewing Editor at Experimental Results (Cambridge Uni. Press) and has been reviewer in various reputed journals such as Small, Chem Eur J, Nanoscale, among others. Over the years, V. Francisco has been integrated in the team of several research projects funded by European Commission, Gobierno de España (Agencia Estatal de Investigacion) and Portuguese Science Foundation (FCT). Moreover, V. Francisco has also participated in several national and international conferences often contributing with oral presentations (18 in total), including two invited lectures at AEICBAS Biomedical Congress and EMBE2022. In the last 5 years he secured, as Principal Investigator, 340k Eur (240 k in 2018, 50k in 2022 and 50k in 2024) from the national funding agency (FCT). In the project started in 2018 and finished in 2022, the aim was to develop a platform for the delivery of RNA-based therapies. The results of this project were published in medium/high impact journals such as Adv. Science (IF = 14.3), Angew Chemie (IF = 15.336) or Nanoscale Horizons (IF = 11.684) and one patent was granted. Since 2021, he is also Co-PI of another FCT project (50k Eur) for developing a gene editing nanoparticle formulation for retinal degeneration diseases. Alongside his research activities, V. Francisco has experience teaching at BSc level, "Biomedical Engineering", as well as "Regenerative Medicine" and "Advanced Therapies" courses at MSc and PhD level. Throughout the years he has mentoring/tutoring >10 graduated students, and he is currently supervising/co-supervising 2 Master student and 3 PhD students. He was elected CIBB post-doctoral representatives (2016-2018), where he was involved in one evaluation of the host institution and also in the organization of a symposium for PhD students and Post-Doc researchers. V. Francisco has also contributed to several outreaching activities with the general public as well as high-school students, such as European Research Night or Science Fairs and participated in TV/radio shows as Mentes que Brilham (Porto Canal) and 90 segundos de Ciência (Antena 1).
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Identification

Personal identification

Full name
Vitor Manuel dos Santos Francisco

Citation names

  • Francisco, Vitor

Author identifiers

Ciência ID
7A1A-3400-E0A5

Email addresses

  • francisco.vms@cnc.uc.pt (Professional)

Knowledge fields

  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2014/01/10
Concluded
 Chemistry (Doctor)
Major in Physical Chemistry
Universidade de Santiago de Compostela, Spain
"Thermodynamic and structural studies on the interaction of guests with macrocycles" (THESIS/DISSERTATION)
 Approved unanimously with distinction and praise
2010/09/22
Concluded
 Science and Technology of Colloids and Interfaces (Mestrado)
Universidade de Santiago de Compostela, Spain
"Vesículas a partir dun complexo de inclusíon entre un calixareno e un surfactante (Supramolecular vesicles formed between a calixarene and a surfactant)" (THESIS/DISSERTATION)
 Excellent (10.0)
2008
Concluded
 Chemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Estudio cinético de una reacción autocatalítica: nitrosación del disulfuro de formamidina (Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide)" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/07/01 - Current Contracted Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015/03/01 - 2018/06/30 Postdoc (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2014/03/15 - 2015/02/28 Researcher (Research) Biocant Associação de Transferência de Tecnologia, Portugal
2013/01/01 - 2013/12/31 Researcher (Research) Universidade de Santiago de Compostela - Campus Vida, Spain
2012/09/01 - 2012/11/30 Visiting Researcher (Research) Jacobs University Bremen gGmbH, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2022/09/01 - Current Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Coimbra, Portugal
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
Projects

Grant

Designation Funders
2023/01/01 - 2025/12/31 Heat-induced epithelial permeability: a nanoscale-based solution for the treatment of fungal keratitis
na
Researcher
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
 Centro Hospitalar e Universitário de Coimbra EPE
Ongoing
2023/12/20 - 2024/07/31 Contact lens modified with nanotechnology for keratoconus treatment
Provas de Conceito UC by Santander Universidades
Universidade de Coimbra Centro de Investigação em Engenharia dos Processos Químicos e dos Produtos da Floresta, Portugal
 Banco Santander Portugal
Ongoing

Contract

Designation Funders
2025/01/01 - Current A nanotherapeutic strategy to tackle vascular cell senescence
2023.12423.PEX
Principal investigator
Fundação para a Ciência e a Tecnologia
2023/03/01 - Current Targeted senolytic delivery system to treat liver cirrhosis
2022.02783.PTDC
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - Current Nanomedicine and trojan cells for leukemic niche intervention
2022.05946.PTDC
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - Current A gene editing nanoparticle formulation for retinal degeneration diseases
EXPL/BIA-CEL/0989/2021
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - Current Enhancing epithelial permeability: a nanotechnology-based solution for epi-on corneal cross-linking
EXPL/BIA-BQM/0042/2021
Researcher
Universidade de Coimbra, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/06 - 2022/07/05 LIghtBRARY: A light-activatable nanoparticle library for the delivery of RNA-based therapies
POCI-01-0145-FEDER-029414
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/06/30 Tackling Cancer Stem Cells: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/07/01 - 2020/06 Enhancing Research in Ageing at the University of Coimbra
eu-repo/grantAgreement/EC/H2020/669088/EU
Post-doc
Universidade de Coimbra Faculdade de Medicina, Portugal
 European Commission
Concluded
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2017 Triggerable nanomaterials to modulate cell activity - NanoTrigger
307384
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Research Council
Concluded
2014/03/15 - 2016/03/14 Personalized 3D vascular constructs for toxicity assessment - VASCTOX
PTDC/SAU- TOX/121887/2010
Post-doc Fellow
Biocant Associação de Transferência de Tecnologia, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2014/12/31 Reactivity in colloidal systems derived from supramolecular aggregates
CTQ2011-22436
PhD Student Fellow
Universidade de Santiago de Compostela, Spain
 Gobierno de España Agencia Estatal de Investigación
Concluded
2010/08/10 - 2013/09/30 Self-assembly of supramolecular aggregates
10PXIB209113PR
PhD Student Fellow
Universidade de Santiago de Compostela, Spain
 Xunta de Galicia
Concluded
Outputs

Publications

Conference abstract
  1. Luis Monteiro; Pitrez, Patricia R.; N Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; Francisco, Vitor; et al. "Modeling and drug screening on human cardiomyocytes derived from hutchinson-gilford progeria syndrome induced pluripotent stem cells". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022.
    Published
  2. Luis Monteiro; Patricia Pitrez; S. Correia Santos ; Sardão, Vilma; Francisco, Vitor; Cortes, Luisa; Ferreira, Lino. "Cardiovascular & metabolic diseases modeling of ageing in human cardiomyocytes derived from induced pluripotent stem cells". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022.
    Published
  3. Ricardo Pires das Neves; Quartin, Emanuel; González Antón, Sara; Rosa, Susana; Francisco, Vitor; Mosteo, Laura; Duarte, Delfim; Lo Celso, Cristina ; Ferreira, Lino. "Cells as therapeutical vehicles for the delivery of light sensitive retinoic acid nanoparticles for leukemic niche modulation". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021.
    Published
  4. Francisco, Vitor; Josephine, Blersch; Rebelo, Catarina; Ferreira, Lino. "High-throughput screening of nanoparticles to efficiently deliver non-coding RNA". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Coimbra, 2021.
    Published
  5. Estronca, LM; Francisco, Vitor; Ferreira, Lino. "Development of Cell Platforms derived from induced pluripotent stem cells for screening toxicity of nanomaterials". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021.
    Published
  6. Moreira, José A.; García-Río, Luís; Stedman, Geoffrey; Francisco, Vitor. "The kinetics and mechanism of the reaction of nitrous acid with formamidine disulfide". Paper presented in XIX IUPAC Conference on Physical Organic Chemistry, Santiago de Compostela, 2008.
    Published
Conference poster
  1. Henriques, Mauro; Andreia Marques; Ines Tomé; Francisco, Vitor; Ferreira, Lino. "Engineering nanoformulations for senotherapeutics delivery". Paper presented in 3rd RESETageing conference, 2024.
  2. Henriques, Mauro; Marques, Andreia; Ines Tomé; Francisco, Vitor; Lino da Silva Ferreira. "Engineering nanoformulations for senotherapeutics delivery". Paper presented in 3rd RESETageing Conference, 2023.
  3. Pitrez, João; Marques, Andreia; Tomé, Inês; Rosa, Susana; Francisco, Vitor; Ferreira, Lino. "Senescence in liver sinusoidal endothelial cells: implications for age-related liver changes". Paper presented in 3rd RESETageing Conference, 2023.
  4. Tomé, Inês; Rosa, Susana; Sanfeliu-Redondo, D.; Aristu-Zabalza, P.; Vizioli, M.G.; Pitrez, P.; Gracia-Sancho, Jordi; et al. "Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles". Paper presented in 3rd RESETageing Conference, 2023.
  5. H.R. Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. "A Nanoparticle-based Innovative Senotherapy". Paper presented in European Tissue Repair Society (ETRS) and Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) Joint Meeting, 2023.
  6. Tomé, Inês; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Suana Rosa; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Diana Jurk; Francisco, Vitor; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, 2023.
  7. Inês Tomé Ribeiro; Rosa, Susana; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Pitrez, Patrícia; Gracia-Sancho, Jordi; Francisco, Vitor; Diana Jurk; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, 2023.
  8. Francisco, Vitor; Rodrigues, Artur Filipe; Rebelo, Catarina; Paulo, Cristiana; Rita Pereira; Simões, Susana; Pinho, Sonia L. C:; Ferreira, Lino. Corresponding author: Francisco, Vitor. "A nano formulation for targeted mRNA delivery to tackle fibrotic diseases". Paper presented in Ageing Without Borders, 2022.
  9. Helena R Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. Corresponding author: Helena R Aires. "Senolysis as a therapeutic approach for cardiovascular aging". Paper presented in Ageing Without Borders, 2022.
  10. Monteiro, Luís; Pitrez, Patricia R.; Correia-Santos, Simão; Nicola Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; et al. Corresponding author: Monteiro, Luís. "Disease modeling and drug screening on cardiomyocytes derived from Hutchinson-Gilford Progeria Syndrome- induced pluripotent stem cells". Paper presented in The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
  11. Rodrigues, Artur Filipe; Catarina Rebelo; Pinho, Sonia L. C:; Francisco, Vitor; Ferreira, Lino. Corresponding author: Francisco, Vitor. "High-throughput screening of combinatorial polymers library of nanoparticles for controlled delivery of mRNA". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  12. Francisco, Vitor; Lino da Silva Ferreira. "Near-infrared light triggered release of bioactive molecules from supramolecular modified gold nanorods". Paper presented in 29th Annual Meeting of the European Society for Biomaterials, 2018.
  13. Francisco, Vitor; Lino da Silva Ferreira. "Near-infrared light triggered release of bioactive molecules from supramolecular modified gold nanorods". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
    10.1109/wrap.2017.8468598
  14. Francisco, Vitor; Costa, Catarina; Vale, Maria Luisa C.; Garcia-Rio, Luis; Marques, Eduardo F.. "Supramolecular aggregation in cationic/anionic mixtures of calixarene and serine-based surfactants". Paper presented in 5th Iberian Meeting on Colloids and Interfaces, 2013.
  15. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis. "Host:Guest binding constant influenced by the host counterion". Paper presented in 3rd Portuguese Young Chemists Meeting, 2012.
  16. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis. "Influence of counterion in the formation of host:guest complexes by p-sulfonatocalix[4]arene". Paper presented in 1th International Conference on Calixarenes, 2011.
  17. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis; Marques, Eduardo F.. "Colloidal structures from self-assembling of host-guest complexes". Paper presented in 24th Conference of the European Colloid and Interface Society, 2010.
Journal article
  1. Francisco, Vitor; Andreia Marques; David Sanfeliu-Redondo; Ines Tomé; Rosa, Susana; Jordi Gracia-Sancho; Ferreira, Lino. "Enhancing Safety and Efficacy of Senolytic Therapies with Advanced Controlled Release Strategies". Nature Communications (2025):
    Submitted
  2. Quartin, Emanuel; Rosa, Susana; Gonzalez-Anton, Sara; Mosteo Lopez, Laura; Francisco, Vitor; Duarte, Delfim; Lo Celso, Cristina; Pires das Neves, Ricardo; Ferreira, Lino. "Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche". Bioactive Materials 34 (2024): 311-325. http://dx.doi.org/10.1016/j.bioactmat.2023.12.017.
    10.1016/j.bioactmat.2023.12.017
  3. Marta Machado-Pereira; Alba Grayston; Miguel Garcia-Gabilondo; Francisco, Vitor; Cristóvão, Ana; Marto, João; Ferreira, Lino; et al. Corresponding author: Ferreira, Raquel. "Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke". Stroke (2023): https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041839?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
  4. Rodrigues, Artur Filipe; Rebelo, Catarina; Simões, Susana; Paulo, Cristiana; Pinho, Sónia; Francisco, Vítor; Ferreira, Lino. Corresponding author: Francisco, Vítor. "A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts". Advanced Science 10 5 (2022): 2205475. http://dx.doi.org/10.1002/advs.202205475.
    10.1002/advs.202205475
  5. Kauppila, Maija; Ståhlberg, Roosa; Francisco, Vitor; Ferreira, Lino; Skottman, Heli. "Multi-parametric surface plasmon resonance-based intake quantification of label-free light-activated nanoparticles by therapeutic limbal stem cells for corneal blindness". Nano Select 3 8 (2022): 1232-1241. http://dx.doi.org/10.1002/nano.202200027.
    10.1002/nano.202200027
  6. Tomé, Inês; Francisco, Vitor; Fernandes, Hugo; Ferreira, Lino. Corresponding author: Francisco, Vitor. "High-throughput screening of nanoparticles in drug delivery". APL Bioengineering 5 3 (2021): 031511. http://dx.doi.org/10.1063/5.0057204.
    10.1063/5.0057204
  7. Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions". Nanoscale Horizons (2021): http://dx.doi.org/10.1039/d0nh00550a.
    10.1039/d0nh00550a
  8. Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino. Corresponding author: Francisco, Vitor. "A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies". Methods (2020): http://dx.doi.org/10.1016/j.ymeth.2020.12.002.
    10.1016/j.ymeth.2020.12.002
  9. Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Pinto, Sandra; Simões, Susana; Rai, Akhilesh; Ferreira, Lino. Corresponding author: Francisco, Vitor. "A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)". Nanoscale 12 18 (2020): 9935-9942. http://dx.doi.org/10.1039/c9nr10503d.
    10.1039/c9nr10503d
  10. Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al. "A light-triggerable nanoparticle library for the controlled release of non-coding RNAs". Angewandte Chemie International Edition (2019): http://dx.doi.org/10.1002/anie.201911398.
    10.1002/anie.201911398
  11. Francisco, Vitor; Lino, Miguel; Ferreira, Lino. "A near infrared light-triggerable modular formulation for the delivery of small biomolecules". Journal of Nanobiotechnology 17 1 (2019): http://dx.doi.org/10.1186/s12951-019-0530-y.
    10.1186/s12951-019-0530-y
  12. Garcia-Rio, Luis; Basílio, Nuno; Francisco, Vitor. "Counterion effect on sulfonatocalix[n]arene recognition". Pure and Applied Chemistry 0 0 (2019): http://dx.doi.org/10.1515/pac-2019-0305.
    10.1515/pac-2019-0305
  13. Jiménez-Balsa, Adrián; Pinto, Sandra; Quartin, Emanuel; Lino, Miguel M.; Francisco, Vitor; Ferreira, Lino. "Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules". Bioconjugate Chemistry 29 5 (2018): 1485-1489. http://dx.doi.org/10.1021/acs.bioconjchem.7b00820.
    10.1021/acs.bioconjchem.7b00820
  14. Gómez-González, Borja; Francisco, Vitor; Montecinos, Rodrigo; García-Río, Luis. "Investigation of the binding modes of a positively charged pillar[5]arene: internal and external guest complexation". Organic & Biomolecular Chemistry 15 4 (2017): 911-919. http://dx.doi.org/10.1039/c6ob02573k.
    10.1039/c6ob02573k
  15. Lavande, Nitin; Acuña, Angel; Basílio, Nuno; Francisco, Vitor; Malkhede, Dipalee D.; Garcia-Rio, Luis. "A journey from calix[4]arene to calix[6] and calix[8]arene reveals more than a matter of size. Receptor concentration affects the stability and stoichiometric nature of the complexes". Physical Chemistry Chemical Physics 19 21 (2017): 13640-13649. http://dx.doi.org/10.1039/c7cp01889d.
    10.1039/c7cp01889d
  16. Costa, Catarina; Francisco, Vitor; Silva, Sandra G.; do Vale, M. Luísa C.; García-Río, Luis; Marques, Eduardo F.. "Supramolecular self-assembly between an amino acid-based surfactant and a sulfonatocalixarene driven by electrostatic interactions". Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 (2015): 71-78. http://dx.doi.org/10.1016/j.colsurfa.2015.03.054.
    10.1016/j.colsurfa.2015.03.054
  17. Gómez, Borja; Francisco, Vitor; Fernández-Nieto, Fernando; Garcia-Rio, Luis; Martín-Pastor, M.; Paleo, M. Rita; Sardina, F. Javier. "Host-Guest Chemistry of a Water-Soluble Pillar[5]arene: Evidence for an Ionic-Exchange Recognition Process and Different Complexation Modes". Chemistry - A European Journal 20 38 (2014): 12123-12132. http://dx.doi.org/10.1002/chem.201403194.
    10.1002/chem.201403194
  18. Francisco, Vitor; Basílio, Nuno; García-Río, Luis. "Ionic Exchange in p-Sulfonatocalix[4]arene-Mediated Formation of Metal–Ligand Complexes". The Journal of Physical Chemistry B 118 17 (2014): 4710-4716.
    Published • 10.1021/jp502097q
  19. Francisco, Vitor; Garcia-Rio, Luis. Corresponding author: Francisco, Vitor. "Interaction of Bolaform Surfactants with p-Sulfonatocalix[4]Arene: The Role of Two Positive Charges in the Binding". Langmuir 30 23 (2014): 6748-6755.
    Published • 10.1021/la501337c
  20. Basilio, Nuno; Gómez, Borja; Garcia-Rio, Luis; Francisco, Vitor. "Using Calixarenes To Model Polyelectrolyte Surfactant Nucleation Sites". Chemistry - A European Journal 19 14 (2013): 4570-4576.
    Published • 10.1002/chem.201203377
  21. Figueira-González, María; Francisco, Vitor; García-Río, Luis; Marques, Eduardo F.; Parajó, Mercedes; Rodríguez-Dafonte, Pedro. "Self-Aggregation Properties of Ionic Liquid 1,3-Didecyl-2-methylimidazolium Chloride in Aqueous Solution: From Spheres to Cylinders to Bilayers". The Journal of Physical Chemistry B 117 10 (2013): 2926-2937.
    Published • 10.1021/jp3117962
  22. Basilio, Nuno; Francisco, Vitor; Garcia-Rio, Luis. "Aggregation of p-Sulfonatocalixarene-Based Amphiphiles and Supra-Amphiphiles". International Journal of Molecular Sciences 14 2 (2013): 3140-3157.
    Published • 10.3390/ijms14023140
  23. Francisco, Vitor; Piñeiro, Angel; Nau, Werner M.; García-Río, Luis. "The "True" Affinities of Metal Cations to p-Sulfonatocalix[4]arene: A Thermodynamic Study at Neutral pH Reveals a Pitfall Due to Salt Effects in Microcalorimetry". Chemistry - A European Journal 19 52 (2013): 17809-17820.
    Published • 10.1002/chem.201302365
  24. Francisco, Vitor; Basilio, Nuno; García-Río, Luis. "Counterion Exchange as a Decisive Factor in the Formation of Host:Guest Complexes by p-Sulfonatocalix[4]arene". The Journal of Physical Chemistry B 116 17 (2012): 5308-5315.
    Published • 10.1021/jp301290u
  25. Basílio, Nuno; Francisco, Vitor; García-Río, Luis. "Independent Pathway Formation of Guest–Host in Host Ternary Complexes Made of Ammonium Salt, Calixarene, and Cyclodextrin". The Journal of Organic Chemistry 77 23 (2012): 10764-10772.
    Published • 10.1021/jo302074x
  26. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis; Leis, Jose R.; Maques, Eduardo F.; Vázquez-Vázquez, Carlos. "Novel catanionic vesicles from calixarene and single-chain surfactant". Chemical Communications 46 35 (2010): 6551-6551.
    Published • 10.1039/c0cc01806f
  27. Francisco, Vitor; Garcia-Rio, Luis; António Moreira, José; Stedman, Geoffrey. "Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide". New Journal of Chemistry 32 12 (2008): 2292-2292.
    Published • 10.1039/b810761k

Intellectual property

Patent
  1. Francisco, Vitor Manuel dos Santos; García-Río, Luis; Basilio, Nuno; Leis, Jose R.. 2011. "Lyophilisable vesicles without cryoprotectant". Spain.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/24 Nanoformulations to tackle senescent cells 10th Iberian Meeting on Colloids and Interfaces
University of Coimbra (Coimbra, Portugal)
2024/05/15 Nanobiotechnology in biomedical engineering 15a Jornadas de Engenharia Biomédica 2024
(Coimbra, Portugal)
2023/12/07 Biodegradable anti-senescence nanoparticles 3rd RESETageing Conference
University of Coimbra (Coimbra, Portugal)
2023/09/04 Engineering nanoparticles for an efficient delivery of senolytics to the aged liver 33rd Annual Conference of the European Society for Biomaterials
European Society for Biomaterials (Davos, Switzerland)
2023/06/29 Senotherapeutic nanoparticles to target senescent cells in the liver DGfA Meeting
Leibniz Institute on Aging (Jenna, Germany)
2022/10/13 A nanotechnology-based solution for EPI-ON corneal cross-linking 23rd European Association for Vision and Eye Research
EVER (Valencia, Spain)
2022/01/31 Light responsive nanoparticles for drug delivery International Symposium on Emerging Materials for Biomedical Engineering (EMBE2022)
PDPM IIITDM (India)
2021/09/07 Engineering nanoparticles for targeted delivery of RNA-based therapies 31st Conference of the European Society for Biomaterials (ESB)
European Society for Biomaterials (Porto, Portugal)
2021/06/10 High-throughput screening of nanoparticles to efficiently deliver non-coding RNA 55th ESCI Annual Scientific Meeting
ESCI (Barcelona, Spain)
2020/01/22 Controlled delivery of siRNA via photodegradable polymeric nanoparticle library XIII Spanish-Portuguese Conference on Controlled Drug Delivery
Controlled Release Society (Santiago de Compostela, Spain)
2019/05/22 Efficient non-coding RNA delivery in wound healing by photo-triggerable nanoparticles 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
Universidade de Coimbra (Coimbra, Portugal)
2019/03/14 Advances in Stem Cell Research and Therapeutics: an ethical dilemma? VII AEICBAS Biomedical Congress
AEICBAS (Porto, Portugal)
2017/10/12 Light-triggerable nanoparticles for the efficient in-vivo non-coding RNA delivery in wound healing The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
(Lisbon, Portugal)
2014/07/22 Supramolecular systems based on surfactants and p-sulfonatocalix[4]arene 20th International Symposium on Surfactants in Solution
University of Coimbra (Coimbra, Portugal)
2013/06/26 Micellar shape transition in an imidazolium based-surfactant 5th Iberian Meeting on Colloids and Interfaces
University of San Sebastian (Donostia-San Sebastian)
2012/01/13 Estudio de ITC de la influencia de la sal en la complejacion de un cation amonio por el p-sulfonatocalix[4]arene. III Encuentro Gallego de Cinetica y Catalisis
University of Ourense (Ourense, Spain)
2011/07/13 Vesicular aggregates from supramolecular surfactants 4th Iberian Meeting on Colloids and Interfaces
Faculty of Science - University of Porto (Porto, Portugal)
2008/07/13 Kinetic Study of an Autocatalytic Reaction: Nitrosation of Formamidine Disulfide XIX IUPAC Conference on Physical Organic Chemistry
University of Santiago de Compostela (Santiago de Compostela, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/15 - Current Development and Validation of a Medical Device Based on Nanotechnology for the Treatment of Corneal Diseases
Co-supervisor of Patricia Nápoles
 Engenharia Biomédica (Master)
Universidade de Coimbra, Portugal
2024/09/01 - Current A senolytic delivery system to target the blood brain barrier
Co-supervisor of Anis Shahzad
 Ciências da Saúde (PhD)
Universidade de Coimbra, Portugal
2020/11/30 - Current Reducing senescent cell burden in aging with nanoparticles
Co-supervisor of Andreia Marques
 Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/01 - Current A senolytic delivery system able to cross the blood brain barrier
Co-supervisor of Inês Tomé
 Ciências da Saúde (PhD)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2023/10/01 - 2024/07/22 Development of pharmacological nanoformulations to eliminate senescent cells
Co-supervisor of Mauro Henriques
 Bioengenharia (Master)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2021/06/01 - 2024/07/22 Polymeric nanoparticles for gene editing
Co-supervisor
 PhDExperimental Biology and Biomedicine (PDBEB) (PhD)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2022/10/01 - 2023/12/12 Targeted senolytic delivery system to treat liver cirrhosis
Supervisor of João Pedro Oliveira Santos Pitrez
 Engenharia Química e Biológica (Master)
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/09/01 - 2023/09/15 A nanotechnology-based solution for enhancing corneal permeability
Co-supervisor of João Pedro Cidra
 Ciências de Engenharia Biomédica (Master)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra, Portugal
2022/09/01 - 2023/07/15 Improve corneal permeability in keratoconus treatment: a solution based on nanotechnology
Co-supervisor of Rita Isabel Martins Pais
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/03/01 - 2022/07/21 Tackling senescence in brain aging
Supervisor of Mauro Henriques
 Engenharia Biológica (Degree)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/01/01 - 2021/12/31 Light-triggerable delivery of mRNA nanoparticles
Supervisor of Catarina Rebelo
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/09/01 - 2020/12/15 Development of nanoparticles to target senescent cells
Co-supervisor of Ricardo Casqueiro
 Investigação Biomédica (Master)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/06/01 - 2020/04/30 mRNA nanoparticles to improve wound healing
Supervisor of Artur Filipe Rodrigues
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/12/06 - 2023/12/07 3rd RESETageing conference (2023/12/06)
Conference (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2019/06/28 - 2019/06/29 Ageing: models, mechanisms and therapies (2019/06/28 - 2019/06/29)
Conference (Member of the Organising Committee)
 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06/27 - 2018/06/27 "Ageing: models and therapies" (2018/06/27 - 2018/06/27)
Workshop
 Universidade de Coimbra, Portugal
2018/03/23 - 2018/03/23 Overcoming Challenges in Scientific Careers, the Biomedical Research Post-Doctoral Forum@UC (2018/03/23 - 2018/03/23)
Symposium (Co-organisor)
 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2008/07/13 - 2008/07/18 XIX IUPAC Conference on Physical Organic Chemistry (2008/07/13 - 2008/07/18)
Conference (Member of the Organising Committee)
 Universidade de Santiago de Compostela, Spain

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/01/16 Breaking the classic antibiotic barrier: Micro and nanoparticles for Helicobacter pylori management
(Thesis) Main arguer
 Diana Fonseca (PhD)
Universidade do Porto, Portugal
2023/07/28 Targeted polymeric nanoparticles for the treatment of fibrosis
(Thesis) Main arguer
 Rita Durão Rosa Pereira (Master)
Universidade de Coimbra, Portugal
2023/03/13 Evaluation of the presence of nitrosamines in pharmaceuticals (Avaliação da presença de nitrosamines em medicamentos)
(Thesis) Main arguer
 Filipa Alexandra Duque Fonseca (Master)
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/07/19 Development of nanoparticles for delivery of senolytics at the blood-brain barrier
(Thesis) Arguer
 Mauro Henriques (Other)
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2021/07/07 Evaluation of the effect of NIR radiation on the cornea and retina
(Thesis) Main arguer
 Jéssica Monteiro (Other)
Universidade de Coimbra, Portugal

Association member

Society Organization name Role
2019/07/21 - Current Controlled Release Society (CRS)
2019/05/22 - Current European Society for Clinical Investigation (ESCI)
2018/09/09 - Current European Society for Biomaterials (ESB)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/02/21 - Current Biochemistry and Molecular Biology Engenharia Biomédica (Licenciatura) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/09/01 - Current Cell and Tissue Biology Engenharia Biomédica (Licenciatura) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2018/09/26 - Current Regenerative Medicine Engenharia Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/05/07 - Current PhD Programme in Experimental Biology and Biomedicine (PDBEB) Doctoral Program in Experimental Biology and Biomedicine (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Interview (tv / radio show)

Program Topic
2021/01/13 - Current 90 segundo de Ciência Método inovador e sensível à luz para a entrega de moléculas em doenças da pele
2020/02/18 - 2020/02/18 Mentes que Brilham

Journal scientific committee

Journal title (ISSN) Publisher
2022/09/05 - Current Frontiers in Biomaterials Science for Regenerative Therapies Frontiers
2022/03/25 - Current Frontiers in Chemistry
2020/07/21 - Current Experimental Results Cambridge University Press

Mentoring / Tutoring

Topic Student name
2021/03/01 - Current Nanoparticles to target senescent vascular cells Helena Aires
2020/10/01 - Current Synthesis and role of piezoelectric nanoparticles on cardiomyocytes Luis Monteiro
2015/01/01 - Current A light-triggerable nanocarrier library to modulate cell activity Josephine Blersch
2021/01/04 - 2021/01/29 Synthesis and characterisation of an enzyme-responsive delivery system Jakub Misturik
2020/06/29 - 2020/07/18 Senoterapeutic drug delivery systems Filipe de Campos Hipolito Pedroso Mateus
2018/03/05 - 2018/10/31 A light-activatable nanoparticle library for the delivery of RNA-based therapies Filipe Coelho
2017/09/01 - 2018/03/31 Synthesis of light sensitive nanoparticles for drug delivery Mehrzad Zargarzadeh
2016/10/01 - 2017/10/31 Characterisation of a light sensitive nanoparticle library Malwina Kotowicz
Distinctions

Award

2024 Best innovation in Acelera@UC 2024 Best innovation in Acelera@UC 2024 - Training Programme for Entrepreneurs, Project: NanoLensTech
Universidade de Coimbra, Portugal
2023 Winner of 2nd edition of BiotechSTARS BioBOOST (Bio-entrepreneurship Mentoring Program) - Project NanoLensTech
Biocant Associação de Transferência de Tecnologia, Portugal
2022 Prémio de Investigação Centro Hospitalar e Universitário de Coimbra - Projeto de investigação translacional (Heat-induced epithelial permeability: A nanoscale-based solution for the treatment of fungal keratitis)
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2020 Best Poster at XIII Spanish-Portuguese Conference on Controlled Drug Delivery
Spanish Portuguese Local Chapter (SPLC-CRS), Spain

Other distinction

2021 Feature Article - https://doi.org/10.1063/5.0057204
American Institute of Physics (AIP), United States
2017 HOT Article PCCP - https://doi.org/10.1039/C7CP01889D
Royal Society of Chemistry, United Kingdom
2014 Postdoctoral Research Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2008 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal