Book |
- Pedro Oliveira, J.; Caixinha, Miguel; Aires, Ines D.; Santiago, Ana Raquel; Santos, Mario; Santos, Jaime. In Vivo Detection
of Cornea Structural Changes In An Animal Model Of Diabetes Mellitus. 2017.
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Conference paper |
- Aires, Inês Dinis; Raquel Boia; Teresa Ribeiro Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago.
"Exosomes from microglia under elevated pressure promote retinal neuroinflammation and degeneration". Paper presented in GLIA,
Porto, 2019.
10.1002/glia.23675
- Raquel Boia; J. Ferreira Silva; Aires, Inês Dinis; António Francisco Ambrósio; Ana Raquel Santiago. "Adenosine A3 receptor
activation reduces microglia reactivity triggered by elevated hydrostatic pressure". Paper presented in GLIA, Porto,
2019.
10.1002/glia.23675
- Pedro Oliveira, J.; Caixinha, Miguel; Aires, Ines D.; Santiago, Ana Raquel; Santos, Mario; Santos, Jaime. "In vivo detection
of cornea structural changes in an animal model of diabetes mellitus". 2017.
10.1109/enbeng.2017.7889445
- Boia, R.; Madeira, M.H.; Aires, I.D.; Neves, C.R.; Ambrósio, A.F.; Santiago, A.R.. "Contribution of microglia-mediated neuroinflammation
to retinal degenerative diseases". Paper presented in Acta Ophthalmologica, 2017.
10.1111/j.1755-3768.2017.03622
- António Francisco Ambrósio; Aires, Inês Dinis; Ana Catarina Rodrigues-Neves; Raquel Boia; Maria Helena Madeira; Ana Raquel
Santiago. "Control of microglia reactivity elicited by elevated hydrostatic pressure through A2A receptor blockade". Paper
presented in Society for Neuroscience, Washington, DC, 2015.
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Conference poster |
- Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Aires, Inês Dinis; Vidal-Sanz, Manuel; AGUDO-BARRIUSO, MARTA; Santos,
Paulo F.; et al. "Activation of the adenosine A3 receptor as a new strategy to rescue retinal ganglion cells from ischemic
damage". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
- Aires, Inês Dinis. "The inflammatory signal elicited by exosomes isolated from reactive microglia is perpetuated by resident
retinal microglia in vivo". Paper presented in 15th Virtual European Meeting on Glial Cells in Health and Disease on July
5 – 9, 2021, 2021.
- Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Aires, Inês Dinis; Vidal-Sanz, Manuel; AGUDO-BARRIUSO, MARTA; Santos,
Paulo F.; et al. "Intraocular biodegradable implants loaded with A3 receptor agonist rescue retinal ganglion cells from ischemic
damage". Paper presented in 2021 CRS Virtual Annual Meeting, 2021.
- Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Aires, Inês Dinis; Vidal-Sanz, Manuel; AGUDO-BARRIUSO, MARTA; Santos,
Paulo F.; et al. "Long-lasting retinal neuroprotection by an adenosine A3 receptor agonist loaded in an intraocular biodegradable
implant". Paper presented in 3rd SPLC-CRS Young scientists virtual meeting, 2021.
- Aires, Inês Dinis; Teresa Ribeiro Rodrigues; Raquel Boia; Steve Catarino; Daniela Almeida; Henrique Girão; António Francisco
Ambrósio; Ana Raquel Santiago. "Exosomes released by microglia under elevated hydrostatic pressure promote retinal cell loss
and microglia reactivity". Paper presented in IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation
and Neurodegeneration, 2019.
- Carolina Santos; Raquel Boia; Aires, Inês Dinis; António Francisco Ambrósio; Ana Raquel Santiago. "The adenosine A3 receptor
agonist is protective to the retinas of diabetic mice". Paper presented in IV Symposium of the Portuguese Glial Network
- Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
- Raquel Boia; Joana Silva; Inês Dinis Aires; António Francisco Ambrósio; Ana Raquel Santiago. "The adenosine A3 receptor agonist
hampers microglia inflammatory phenotype triggered by elevated pressure". Paper presented in IV Symposium of the Portuguese
Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
- Aires, Inês Dinis; Ana Raquel Santiago; Teresa Ribeiro Rodrigues; Raquel Boia; Steve Catarino; Daniela Almeida; Henrique Girão;
António Francisco Ambrósio; Santiago, Ana Raquel. "Extracellular vesicles released by microglia exposed to elevated hydrostatic
pressure promote retinal neural cell loss and microglia reactivity". Paper presented in Association for Research in Vision
and Ophthalmology (ARVO) Annual Meeting, 2019.
- Raquel Boia; Joana Margarida Martins; P.A.N. Dias; Caridad Galindo-Romero; Aires, Inês Dinis; Manuel Vidal-Sanz; Agudo-Barriuso,
Marta; et al. "Safety of a new biodegradable poly(¿-caprolactone) implant to the retina of Wistar rats". Paper presented in
XXIII Biennial Meeting of the International Society for Eye Research, 2018.
- Aires, Inês Dinis; Raquel Boia; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "Treatment with an
adenosine A2A receptor antagonist restores microglia phenotype and protects the retina in a mouse model of diabetic retinopathy".
Paper presented in III Symposium of the Portuguese Glial Network, 2018.
- Carolina Santos; Raquel Boia; Aires, Inês Dinis; António Francisco Ambrósio; Ana Raquel Santiago. "Effect of adenosine A3
receptor agonist treatment in microglial reactivity in a mouse model of diabetic retinopathy". Paper presented in III Symposium
of the Portuguese Glial Network, 2018.
- Raquel Boia; Aires, Inês Dinis; António Francisco Ambrósio; Ana Raquel Santiago. "Adenosine A2A receptor blockade prevents
human retinal microglia reactivity elicited by elevated pressure". Paper presented in III Symposium of the Portuguese Glial
Network, 2018.
- Joana Ferreira Silva; Raquel Boia; Aires, Inês Dinis; Joana Margarida Martins; António Francisco Ambrósio; Ana Raquel Santiago.
"Activation of adenosine A3 receptors prevents microglial reactivity triggered by elevated hydrostatic pressure". Paper presented
in at III Symposium of the Portuguese Glial Network, 2018.
- Aires, Inês Dinis; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Blockade of A2A receptor controls human
retinal microglia response in an in vitro model of elevated pressure". Paper presented in EMBO Workshop – Microglia 2018,
2018.
- Aires, Inês Dinis; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "Intravitreal injection of an adenosine
A2A receptor antagonist restores microglia phenotype and protects the retina in a mouse model of diabetic retinopathy". Paper
presented in EMBO Workshop – Microglia 2018, 2018.
- Aires, Inês Dinis; Teresa Ribeiro Rodrigues; Raquel Boia; Daniela Almeida; António Francisco Ambrósio; Henrique Girão; Ana
Raquel Santiago. "Microglial derived extracellular vesicles trigger a pro-inflammatory phenotype in naïve cells in an in vitro
model of glaucoma". Paper presented in 1st Meeting on Vesicular Biology, 2018.
- Aires, Inês Dinis; Paulo Pereira; Ana Raquel Santiago. "Deadly delivery: unraveling the contribution of microglial exosomes
to retinal degeneration in glaucoma". Paper presented in VI Annual PhDOC meeting, 2017.
- Aires, Inês Dinis; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "Intravitreal injection of adenosine
A2A receptor antagonist reduces neuroinflammation and vascular leakage in the retinas of diabetic mice". Paper presented in
XV Meeting of the Portuguese Society for Neuroscience, 2017.
- Ana Catarina Rodrigues-Neves; Aires, Inês Dinis; Maria Helena Madeira; Raquel Boia; Joana Vindeirinho; António Francisco Ambrósio;
Ana Raquel Santiago. "Changes of the adenosinergic system in microglia and retina triggered by elevated pressure". Paper presented
in XLVII Annual meeting of the Portuguese Society of Pharmacology, 2017.
- Raquel Boia; Filipe Elvas; Maria Helena Madeira; Aires, Inês Dinis; Pedro Tralhão; Younis Baqi; Christa E. Müller; et al.
"Caffeine and A2A receptor antagonism control microglia reactivity and afford protection against transient retinal ischemia".
Paper presented in XXII Biennial Meeting of the International Society for Eye Research, 2016.
- Aires, Inês Dinis; Ana Catarina Rodrigues-Neves; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Blockade of
adenosine A2A receptor prevents retinal microglia reactivity and oxidative/nitrosative stress triggered by elevated pressure".
Paper presented in XXII Biennial Meeting of the International Society for Eye Research, 2016.
- Aires, Inês Dinis; Ana Catarina Rodrigues-Neves; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Adenosine
A2A receptor blockade prevents microglia-mediated retinal neurodegeneration triggered by elevated hydrostatic pressure". Paper
presented in XXII Biennial Meeting of the International Society for Eye Research, 2016.
- Aires, Inês Dinis; Raquel Boia; Carla Marques; António Francisco Ambrósio; Ana Raquel Santiago. "Blockade of adenosine A2A
receptors controls microglia-mediated neuroinflammation and prevents retinal cell death induced by elevated hydrostatic pressure".
Paper presented in EMBO Young Scientists Forum (EYSF), 2016.
- Ana Catarina Rodrigues-Neves; Inês Dinis Aires; Maria Helena Madeira; Raquel Boia; Joana Vindeirinho; António Francisco Ambrósio;
Ana Raquel Santiago. "Impairment of the adenosinergic system in microglia and retina triggered by elevated pressure". Paper
presented in EMBO Young Scientists Forum (EYSF), 2016.
- Aires, Inês Dinis; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago. "Control of EHP-induced neuroinflammation
through A2AR blockade". Paper presented in 7th Annual Meeting of IBILI, 2015.
- Ana Catarina Rodrigues-Neves; Aires, Inês Dinis; Joana Vindeirinho; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago.
"Impact of elevated pressure in the adenosinergic system and in the release of proinflammatory cytokines in microglia". Paper
presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015.
- Aires, Inês Dinis; Raquel Boia; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "A2A receptor blockade
prevents microglia reactivity elicited by elevated hydrostatic pressure". Paper presented in XIV Meeting of the Portuguese
Society for Neurosciences, 2015.
- Raquel Boia; Maria Helena Madeira; Aires, Inês Dinis; Filipe Elvas; Pedro Tralhão; António Francisco Ambrósio; Ana Raquel
Santiago. "Caffeine administration prevents retinal neuroinflammation in experimental model of glaucoma". Paper presented
in IV In4Med, 2015.
- Ana Catarina Rodrigues-Neves; Aires, Inês Dinis; Joana Vindeirinho; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago.
"Elevated hydrostatic pressure increases extracellular adenosine and A2A receptor protein in BV-2 microglia". Paper presented
in 5th PF2MUC Symposium – Zoom in Microglia, 2014.
- Aires, Inês Dinis; Raquel Boia; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "A2A receptor blockade
prevents pressure-induced microglia reactivity". Paper presented in XVIII Congress of the Portuguese Biochemical Society
(SPB), 2014.
- Aires, Inês Dinis; Raquel Boia; Maria Helena Madeira; António Francisco Ambrósio; Ana Raquel Santiago. "Microglia reactivity
induced by elevated pressure is prevented by the blockade of A2A receptor". Paper presented in VI Annual Meeting of IBILI,
2014.
- Ana Catarina Rodrigues-Neves; Aires, Inês Dinis; Joana Vindeirinho; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago.
"High pressure increases extracellular adenosine and A2A receptor protein levels in microglia". Paper presented in VI Annual
Meeting of IBILI, 2014.
- Aires, Inês Dinis; Raquel Boia; Sandra Correia; Filipa Isabel Baptista; Maria Helena Madeira; António Francisco Ambrósio;
Ana Raquel Santiago. "Elevated hydrostatic pressure increases cell proliferation and microglia reactivity in retinal cell
cultures". Paper presented in V Annual Meeting of IBILI, 2013.
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Journal article |
- Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio;
Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules
(2021): https://doi.org/10.3390/biom11060770.
10.3390/biom11060770
- Inês Dinis Aires; Ana Raquel Santiago. "Microglial exosomes in retinal neuroinflammation: focus in glaucoma". Neural Regeneration
Research 16 9 (2021): 1801. http://dx.doi.org/10.4103/1673-5374.306084.
10.4103/1673-5374.306084
- Ferreira-Silva, Joana; Aires, Inês D.; Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel. "Activation of Adenosine
A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure". International Journal of Molecular Sciences
21 19 (2020): 7218. http://dx.doi.org/10.3390/ijms21197218.
10.3390/ijms21197218
- Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Steve Catarino; Henrique Girão; António Francisco Ambrósio; Ana Raquel
Santiago. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal
cells". Glia (2020): https://doi.org/10.1002/glia.23880.
10.1002/glia.23880
- Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Aires, Inês D.; Agudo-Barriuso,
Marta; Ambrósio, António Francisco; Vidal-Sanz, Manuel; Santiago, Ana Raquel. "Activation of adenosine A3 receptor protects
retinal ganglion cells from degeneration induced by ocular hypertension". Cell Death & Disease 11 5 (2020): http://dx.doi.org/10.1038/s41419-020-2593-y.
10.1038/s41419-020-2593-y
- Boia, Raquel; Ruzafa, Noelia; Aires, Inês Dinis; Pereiro, Xandra; Ambrósio, António Francisco; Vecino, Elena; Santiago, Ana
Raquel. "Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead". International
Journal of Molecular Sciences 21 7 (2020): 2262. http://dx.doi.org/10.3390/ijms21072262.
10.3390/ijms21072262
- Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Ana Catarina; Santos, Paulo Fernando;
Ambrósio, António Francisco. "Keep an eye on adenosine: Its role in retinal inflammation". Pharmacology & Therapeutics
(2020): 107513. http://dx.doi.org/10.1016/j.pharmthera.2020.107513.
10.1016/j.pharmthera.2020.107513
- Boia, Raquel; Dias, Paulo A.N.; Martins, Joana M.; Galindo-Romero, Caridad; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso,
Marta; et al. "Porous poly(e-caprolactone) implants: A novel strategy for efficient intraocular drug delivery". Journal
of Controlled Release 316 (2019): 331-348. http://dx.doi.org/10.1016/j.jconrel.2019.09.023.
10.1016/j.jconrel.2019.09.023
- Aires, Inês Dinis; Madeira, Maria Helena; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Martins, Joana Margarida; Ambrósio,
António Francisco; Santiago, Ana Raquel. "Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation,
vascular leakage and cell death in the retina of diabetic mice". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-53627-y.
10.1038/s41598-019-53627-y
- Inês Dinis Aires; Raquel Boia; Ana Catarina Rodrigues-Neves; Maria Helena Madeira; Carla Marques; António Francisco Ambrósio;
Ana Raquel Santiago. "Blockade of microglial adenosine A 2A receptor suppresses elevated pressure-induced inflammation, oxidative
stress, and cell death in retinal cells". Glia 67 5 (2019): 896-914. https://doi.org/10.1002/glia.23579.
10.1002/glia.23579
- Caixinha, Miguel; Oliveira, Pedro; Aires, Inês D.; Ambrósio, António Francisco; Santiago, Ana Raquel; Santos, Mário; Santos,
Jaime. "In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model". Ultrasound in Medicine & Biology
45 3 (2019): 823-832. http://dx.doi.org/10.1016/j.ultrasmedbio.2018.11.002.
10.1016/j.ultrasmedbio.2018.11.002
- Santiago, Ana R.; Boia, Raquel; Aires, Inês D.; Ambrósio, António F.; Fernandes, Rosa. "Sweet Stress: Coping With Vascular
Dysfunction in Diabetic Retinopathy". Frontiers in Physiology 9 (2018): http://dx.doi.org/10.3389/fphys.2018.00820.
10.3389/fphys.2018.00820
- Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha,
Rodrigo A.; et al. "Elevated Pressure Changes the Purinergic System of Microglial Cells". Frontiers in Pharmacology
9 (2018): http://dx.doi.org/10.3389/fphar.2018.00016.
10.3389/fphar.2018.00016
- Aires, Inês. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect
retina against transient ischemic damage". Cell Death Disease (2017):
10.1038/cddis.2017.451
- Aires, Ines Dinis; Ambrosio, Antonio Francisco; Santiago, Ana Raquel. "Modeling Human Glaucoma: Lessons from the in vitro
Models". Ophthalmic Research 57 2 (2017): 77-86. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000393733500001&KeyUID=WOS:000393733500001.
10.1159/000448480
- Aires, I. D.; Rodrigues, T. Ribeiro; Almeida, D.; Ambrosio, A. F.; Girao, H.; Santiago, A. R.. "Exosomes derived from microglia
exposed to elevated pressure elicit a pro-inflammatory response in naive cells". Glia 65 (2017): E486-E487. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403071700749&KeyUID=WOS:000403071700749.
- Aires, I.; Boia, R.; Neves, C.; Madeira, M.; Ambrosio, F.; Santiago, A. R.. "A(2A) receptor blockade prevents microglia reactivity
triggered by elevated hydrostatic pressure". Glia 63 (2015): E157-E157. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356386700278&KeyUID=WOS:000356386700278.
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Thesis / Dissertation |
- Aires, Inês Dinis. "Role of adenosine A2A receptor in pressureinduced retinal microglia reactivity". Master, Universidade
de Coimbra Faculdade de Medicina, 2014.
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