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Joana L. C. Sousa graduated in Chemistry from the Faculty of Sciences of the University of Porto (FCUP) in 2006. Then, she joined the associate laboratory CICECO – Aveiro Institute of Materials at the University of Aveiro (UA) as a research fellow and finished her MSc studies in the fields of Polyoxometalate Chemistry, Nanochemistry and Catalysis in 2009, supervised by Profs Ana Cavaleiro and Helena Nogueira. In 2016, she earned her PhD in Organic Chemistry from the UA, under Prof Artur Silva’s mentoring. From 2017 to 2022, she developed work as organic chemist within the MultiBiorefinery and EpigenGlicON projects at the UA. Afterwards, she was a researcher of the “Molecular Synthesis” group of the Associated Laboratory for Green Chemistry (LAQV)/UA. Her research interests include (i) synthesis, transformation, and structural characterization of oxygen/nitrogen heterocyclic compounds; (ii) chemical upgrading of biomass-derived natural products; (iii) synthesis of bioactive polyphenolic compounds; (iv) evaluation of in chemico antioxidant and anticancer activities. Joana is co-author of 21 SC-indexed articles (6 as corresponding author, 13 as first author, 651 citations, h-index of 10), and 12 oral communications and 35 posters in both national and international scientific conferences.
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Identification

Personal identification

Full name
Joana Lia Cardoso de Sousa

Citation names

  • Sousa, Joana L. C.

Author identifiers

Ciência ID
7B10-20F8-D6CA
ORCID iD
0000-0003-1412-4197
Scopus Author Id
36938560900

Email addresses

  • joanasousa@ua.pt (Professional)

Addresses

  • Department of Chemistry of the University of Aveiro, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2016/10/28
Concluded
 Doctoral Programme in Chemistry (3rd cycle) (Doutoramento)
Major in Organic chemistry
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
"Synthesis of functionalized oxygen heterocyclic compounds. Evaluation of the antioxidant activity of 3-hydroxylated derivatives" (THESIS/DISSERTATION)
 Approved by unanimity with Honours and Distinction
2009
Concluded
 MSc in Materials Derived from Renewable Resources (2nd cycle) (Mestrado)
Universidade de Aveiro CICECO, Portugal
"New materials containing supported polyoxometalates and their application in oxidative catalysis" (THESIS/DISSERTATION)
 17 (out of 20)
2006
Concluded
 First degree in Chemistry (Licenciatura)
Major in Scientific
Universidade do Porto Faculdade de Ciências, Portugal
"Contribution to the synthesis of polyhydroxymethylated pyrrolidine derivatives as precursors of isoazahomonucleosides" (THESIS/DISSERTATION)
 14 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2023/01/15 - Current Researcher (Research) LAQV-REQUIMTE - Polo de Aveiro, Portugal
Universidade de Aveiro Departamento de Química, Portugal
2019/07/01 - 2022/07/15 Researcher (Research) LAQV-REQUIMTE - Polo de Aveiro, Portugal
Universidade de Aveiro Departamento de Química, Portugal
2017/01/01 - 2019/06/30 Postdoc (Research) Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Universidade de Aveiro Departamento de Química, Portugal
2016/09/01 - 2016/12/31 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
2007/09/01 - 2011/12/31 Research Trainee (Research) Universidade de Aveiro, Portugal

Others

Category
Host institution 		Employer
2012/01/01 - 2015/12/31 PhD Scholarship (Ref. SFRH/BD/76407/2011) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Projects

Grant

Designation Funders
2017/01/01 - 2019/06/30 MultiBiorefinery - Multi-purpose strategies for broadband agro-forest and fisheries by-products valorisation: a step forward for a truly integrated biorefinery
POCI-01-0145-FEDER-016403
Post-doc Fellow
Universidade de Aveiro CICECO, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/02/01 - 2026/01/31 Multi-target theranostics for Alzheimer's disease
2022.06064.PTDC
10.54499/2022.06064.PTDC
Team member
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/07/01 - 2022/07/15 EpigenGlicON - Novel C-glycosylated oxygen and nitrogen heterocyclic compounds as potential epigenetically active immune-stimulatory anticancer agents
POCI-01-0145-FEDER-029767
Researcher
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Química Orgânica, Produtos Naturais e Agroalimentares
UID/QUI/00062/2019
Universidade de Aveiro, Portugal

Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CICECO-Instituto de Materiais de Aveiro
UID/CTM/50011/2019
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
LA/P/0008/2020
10.54499/LA/P/0008/2020
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Évora, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 11 - 2011-2012
PEst-C/CTM/LA0011/2011
Research Fellow
Universidade de Aveiro, Portugal

Universidade de Aveiro CICECO, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 Polyoxometalates: from discrete clusters to networks and materials
POCI/QUI/58887/2004
Research Fellow
Universidade de Aveiro CICECO, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Sousa, Joana L. C.; H.M.T. Albuquerque; C. Gonçalves; R.M. Ferreira; S.M. Cardoso; C.S.R. Freire; A.J.D. Silvestre; A.M.S. Silva. Corresponding author: Sousa, Joana L. C.. "Betulinic acid as raw material to produce novel added-value compounds". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, Lisbon, 2022.
    Published
  2. Lucas, M. ; Freitas, M.; Sousa, Joana L. C.; Silva, A.M.S.; Fernandes, E.; Ribeiro, D.. "Evaluation of COX-2 inhibitory activity by hydroxylated and methoxylated 2-styrylchromones". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, 2022.
  3. Lucas, Mariana; Ribeiro, Daniela; Freitas, Marisa; Sousa, Joana L. C.; Silva, Artur; Fernandes, Eduarda. "The impact of B-ring substituents on the styrylchromones' ability to modulate the levels of reactive prooxidant species". 2021.
    10.3390/ecmc2021-11521
  4. Proença, C.; Freitas, M.; Ribeiro, D.; Sousa, Joana L. C.; Silva, A.M.S.; Fernandes, P.A.; Fernandes, E.. "Inhibitory activity of flavonoids on digestive enzymes a-amylase and a-glucosidase". 2019.
  5. Proença, C.; Ribeiro, D.; Freitas, M.; Sousa, Joana L. C.; Fernandes, P.A.; Fernandes, E.. "Structure-related inhibition of protein tyrosine phosphatase 1B (PTP1B) by flavonoids". 2017.
  6. Sousa, Joana L. C.; Talhi, O.; Paz, F.A.A.; Silva, A.M.S.. "3-Bromochromones as Building Blocks of Novel Furan and Cyclopropane Derivatives (OC11)". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry, Porto, 2016.
    Published • 10.3390/ph9010015
  7. Proença, C.; Freitas, M.; Ribeiro, D.; Sousa, Joana L. C.; Silva, A.M.S.; Fernandes, E.. "The Antioxidant Activity of Novel Polyhydroxylated 3-Hydroxy-2-Styrylchromones and 3-Hydroxyflavones (P8)". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry, Porto, 2016.
    Published
Conference poster
  1. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Unlocking the Synthesis of N-Heterocyclic Analogues of 3- Formylchromones". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  2. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Synthesis of 3,5-Disubstituted Nitrobenzenes and their Applications". Paper presented in XXVIII Encontro Nacional da SPQ, 2023.
  3. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "3,5-Disubstituted Nitrobenzenes: Synthesis and Applications". Paper presented in 22nd European Symposium on Organic Chemistry, 2023.
  4. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Artur M. S. Silva; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Synthesis of Symmetrical and Non-Symmetrical Nitrobenzenes from 3- Formylchromones". 2023.
  5. Lucas, Mariana; Freitas, Marisa; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Eduarda; Ribeiro, Daniela. "The impact of B-ring substituents on the styrylchromones' ability to modulate the levels of reactive prooxidant species". Paper presented in 7th International Electronic Conference on Medicinal Chemistry (ECMC 2021), 2021.
  6. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S; Fernandes, Pedro A.; Fernandes, Eduarda. "The potential effect of flavonoids as inhibitors of dipeptidyl peptidase-4 (DPP-4)". Paper presented in IberPhenol - International Conference, 2020.
  7. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda; et al. "Inhibitory activity of flavonoids on digestive enzymes a-amylase and a-glucosidase". Paper presented in 10º Simpósio de Metabolismo, 2018.
  8. Ramos, Patrícia A. B.; Sousa, Joana L. C.; Freire, Carmen S. R.; Silva, Artur M. S.; Silvestre, Armando J. D.. "Chemical characterization of Pinus pinaster bark and needles lipophilic fractions: a valuable resource of diterpene resinic acids". Paper presented in Jornadas CICECO 2018, 2018.
  9. Sousa, Joana L. C.; Ramos, Patrícia A. B.; Freire, Carmen S. R.; Silva, Artur M. S.; Silvestre, Armando J. D.. "Chemical composition of Portuguese P. pinaster and P. pinea bark extracts towards an integrated biorefinery concept". Paper presented in 15th European Workshop on Lignocellulosics and Pulp (EWLP 2018), 2018.
  10. Sousa, Joana L. C.; Freire, Carmen S. R.; Silvestre, Armando J. D.; Silva, Artur M. S.. Corresponding author: Sousa, Joana L. C.. "Decoration of a triterpene scaffold with different nitrogen heterocycles". Paper presented in 28th European Colloquium on Heterocyclic Chemistry (ECHC 2018), 2018.
  11. Sousa, Joana L. C.; Proença, Carina; Freitas, Marisa; Fernandes, Eduarda; Silva, Artur M. S.; Joana L. C. Sousa; Carina Proença; et al. "Synthesis and in vitro antioxidant activity of new polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones". Paper presented in Transmediterranean Colloquium on Heterocyclic Chemistry (TRAMECH) IX, 2017.
  12. Ramos, Patrícia A. B.; Sousa, Joana L. C.; Freire, Carmen S. R.; Silva, Artur M. S.; Silvestre, Armando J. D.. "Chemical characterization of Pinus pinaster bark and needles lipophilic fractions: a valuable resource of diterpene resinic acids". Paper presented in XXV Encontro Nacional da Sociedade Portuguesa de Química, 2017.
  13. Sousa, Joana L. C.; Freire, Carmen S. R.; Silvestre, Armando J. D.; Silva, Artur M. S.. "Functionalization of betulinic acid through Heck reactions". Paper presented in XXV Encontro Nacional da Sociedade Portuguesa de Química, 2017.
  14. Sousa, Joana L. C.; Proença, Carina; Freitas, Marisa; Fernandes, Eduarda; Silva, Artur M. S.. "Synthesis and in vitro antioxidant activity of new flavon-3-ols and 3-hydroxy-2-styrylchromones". Paper presented in TRAMECH IX - 9th Trans Mediterranean Colloquium on Heterocyclic Chemistry, 2017.
  15. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Eduarda. "Flavonoids can mediate inflammation resolution through inhibition of human neutrophils' oxidative burst and leukotriene B4 production". Paper presented in Inflammation, Immunity and Cancer: Neutrophils and Other Leukocytes - The Society for Leukocyte Biology's 49th Annual Meeting with Joint Participation by Neutro2016, 2016.
  16. Sousa, Joana L. C.; Silva, Artur M. S.. "Microwave-assisted tandem reactions towards the synthesis of cyclohepta[b]chromene-9,11-diones". Paper presented in Research Day 2016, University of Aveiro, 2016.
  17. Sousa, Joana L. C.; Mateus, Nuno; Freitas, Victor; Cruz, Luís. "Synthesis and structural characterization of novel pyrano-deoxyanthocyanin dyes". Paper presented in XXII Encontro Luso-Galego de Química, 2016.
  18. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Eduarda. "In vitro antioxidant activity of novel 3-hydroxy-2-styrylchromones as compared to 3-hydroxyflavones". Paper presented in Congresso de Química Orgânica e Química Terapêutica, 2015.
  19. Sousa, Joana L. C.; Talhi, Oualid; Paz, Filipe A. A.; Silva, Artur M. S.. "A one-pot synthesis of furan-based polyphenolics". Paper presented in 19th European Symposium of Organic Chemistry – ESOCXIX, 2015.
  20. Sousa, Joana L. C.; Silva, Artur M. S.. "Synthesis of novel 3-hydroxy-2-styrylchromone derivatives". Paper presented in XXIII Encontro Nacional da Sociedade Portuguesa de Química, 2013.
  21. Sousa, Joana L. C.; Silva, Artur M. S.. "Hydroxylation of flavon-3-ol derivatives". Paper presented in 10º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Brasileiro de Química Orgânica, 2013.
  22. Sousa, Joana L. C.; Silva, Artur M. S.. "Synthesis of new flavon-3-ols with potential antioxidant activity". Paper presented in 3PYCheM - 3rd Portuguese Young Chemists Meeting, 2012.
  23. Sousa, Joana L. C.; Silva, Artur M. S.. "Synthesis of new 3-hydroxy-2-styrylchromones with potential antioxidant activity". Paper presented in 3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  24. Sousa, Joana L. C.; Silva, Artur M. S.. "Efficient synthesis of new polyhydroxylated flavon-3-ols". Paper presented in 4th EuCheMS Chemistry Congress, 2012.
  25. Granadeiro, Carlos M.; Sousa, Joana L. C.; Cavaleiro, Ana M. V.; Nogueira, Helena I. S.. "Polyoxometalates in silica nanoparticles: multifunctional core/shell materials". Paper presented in VIII Jornadas do CICECO, 2011.
  26. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "A sandwich-type polyoxotungstophosphate as heterogeneous catalyst". Paper presented in VII Jornadas do CICECO, 2010.
  27. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "Polyoxometalate/silica nanomaterials as heterogeneous catalysts". Paper presented in 2PYCheM - 2nd Portuguese Young Chemists Meeting, 2010.
  28. Granadeiro, Carlos M.; Sousa, Joana L. C.; Cavaleiro, Ana M. V.; Nogueira, Helena I. S.. "Polyoxometalates in silica nanoparticles: multifunctional core/shell materials". Paper presented in MOLMAT 2010 - IVth International Conference on Molecular Materials, 2010.
  29. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "Polyoxometalate-supported nanostructured materials as oxidative heterogeneous catalysts". Paper presented in VI Jornadas do CICECO, 2009.
  30. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "A comparative study between homogeneous and heterogeneous catalysis in the oxidation of geraniol with hydrogen peroxide". Paper presented in 8º Encontro Nacional de Química Orgânica, 2009.
  31. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "A sandwich-type polyoxotungstophosphate as heterogeneous catalyst". Paper presented in 8ª Conferência de Química Inorgânica, 2009.
  32. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "Polyoxometalate-supported nanostructured materials as oxidative heterogeneous catalysts". Paper presented in Hybrid Materials 2009 – First International Conference on Multifunctional, Hybrid and Nanomaterials, 2009.
  33. Sousa, Joana L. C.; Santos, Isabel C. M. S.; Simões, Mário M. Q.; Cavaleiro, José A. S.; Nogueira, Helena I. S.; Cavaleiro, Ana M. V.. "Polyoxometalate-supported nanostructured materials as oxidative heterogeneous catalysts". Paper presented in International Polyoxometalate Symposium, 2009.
Journal article
  1. Haffas, M.; N. Benkiki; F. Chebrouk; R. Maadadi; R. Menacer; C. Mouffouk; Z. Kabouche; et al. Corresponding author: Sousa, Joana L. C.. "Hemisynthesis of monoterpene-containing pyridin-2-one, pyrano[2,3-c]pyrazole and dicarbamate derivatives: in vitro and in silico anti-inflammatory activity". J. Mol. Struct. (2024):
    Open access • Under revision
  2. S. Tliba; D. Fedaoui; Sousa, Joana L. C.; Silva, A.M.S.; M. Liacha. "Synthesis and characterization of novel benzothiazinonic N-acylhydrazone derivatives". Polycyclic Aromat. Compd. (2024):
    Under revision
  3. Sousa, Joana L. C.; Albuquerque, Hélio M. T.; Silva, Artur M. S.. "Drug Discovery Based on Oxygen and Nitrogen (Non-)Heterocyclic Compounds Developed @LAQV–REQUIMTE/Aveiro". Pharmaceuticals 16 12 (2023): 1668. http://dx.doi.org/10.3390/ph16121668.
    10.3390/ph16121668
  4. Malafaia, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Albuquerque, Hélio M. T.. Corresponding author: Sousa, Joana L. C.. "2,2'-[(1E,1'E)-{[Hexa-2,4-diyne-1,6-diylbis(oxy)]bis(2,1-phenylene)}bis(ethene-2,1-diyl)]bis(4H-chromen-4-one)". Molbank 2023 2 (2023): M1621. http://dx.doi.org/10.3390/m1621.
    Open access • Published • 10.3390/m1621
  5. Sousa, Joana L. C.; Albuquerque, Hélio M. T.; Silva, Artur M. S.. Corresponding author: Sousa, Joana L. C.. "6-[(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidine-4-carbaldehyde". Molbank 2023 1 (2023): M1603. http://dx.doi.org/10.3390/m1603.
    Open access • Published • 10.3390/m1603
  6. Nouali, Fatiha; Sousa, Joana L. C.; Albuquerque, Hélio M.T.; Mendes, Ricardo F.; Paz, Filipe A. Almeida; Saher, Liza; Kibou, Zahira; et al. Corresponding author: Sousa, Joana L. C.. "Microwave-assisted synthesis of 4,6-disubstituted isoindoline-1,3-diones by Diels-Alder reactions". Journal of Molecular Structure 1275 (2023): 134608. http://dx.doi.org/10.1016/j.molstruc.2022.134608.
    Open access • Published • 10.1016/j.molstruc.2022.134608
  7. T.N. Francisco; Sousa, Joana L. C.; S. Guieu; A.M.S. Silva; H.M.T. Albuquerque. "Mild synthesis of symmetric 3,5-disubstituted nitrobenzenes". Synlett 33 (2022): 1505-1510.
    Published
  8. Sousa, Joana L. C.; H.M.T. Albuquerque; A.J.D. Silvestre; A.M.S. Silva. Corresponding author: Sousa, Joana L. C.. "Decoration of A-ring of a lupane-type triterpenoid with different oxygen and nitrogen heterocycles". Molecules 27 (2022): 4904.
    Open access • Published
  9. Sousa, Joana L. C.; Gonçalves, Cristiana; Ferreira, Ricardo M.; Cardoso, Susana M.; Freire, Carmen S. R.; Silvestre, Armando J. D.; Silva, Artur M. S.. Corresponding author: Sousa, Joana L. C.. "Functionalization of Betulinic Acid with Polyphenolic Fragments for the Development of New Amphiphilic Antioxidants". Antioxidants 10 2 (2021): 148. http://dx.doi.org/10.3390/antiox10020148.
    Open access • 10.3390/antiox10020148
  10. Proença, Carina; Oliveira, Ana; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Ramos, Maria J.; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda. "Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase". Journal of Natural Products 83 5 (2020): 1541-1552. http://dx.doi.org/10.1021/acs.jnatprod.0c00014.
    10.1021/acs.jnatprod.0c00014
  11. Sousa, Joana L.C.; Silva, Artur M.S.; Alkorta, Ibon; Elguero, José. "Assignment of 1 H and 13 C NMR data for three pairs of diastereomers of 4'-X benzo[1,3]cyclopropa[1,2-b ]chromene-4,5-diones (X = H, OCH3 , and Cl)". Magnetic Resonance in Chemistry 57 8 (2019): 512-521. http://dx.doi.org/10.1002/mrc.4892.
    10.1002/mrc.4892
  12. Joana L. C. Sousa; Carmen S. R. Freire; Armando Silvestre; Artur M. S. Silva. Corresponding author: Joana L. C. Sousa. "Recent Developments in the Functionalization of Betulinic Acid and Its Natural Analogues: A Route to New Bioactive Compounds". Molecules (2019): http://www.mdpi.com/1420-3049/24/2/355.
    Open access • Published • 10.3390/molecules24020355
  13. Joana L. C. Sousa; Patrícia A. B. Ramos; Carmen S. R. Freire; Artur M. S. Silva; Armando Silvestre. "Chemical Composition of Lipophilic Bark Extracts from Pinus pinaster and Pinus pinea Cultivated in Portugal". Applied Sciences (2018): http://www.mdpi.com/2076-3417/8/12/2575.
    Open access • 10.3390/app8122575
  14. Proença, C.; Freitas, M.; Ribeiro, D.; Sousa, J.L.C.; Carvalho, F.; Silva, A.M.S.; Fernandes, P.A.; Fernandes, E.. "Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study". Food and Chemical Toxicology 111 (2018): 474-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037682773&partnerID=MN8TOARS.
    10.1016/j.fct.2017.11.039
  15. Cruz, L.; Sousa, J.L.C.; Marinho, A.; Mateus, N.; de Freitas, V.. "Synthesis and structural characterization of novel pyranoluteolinidin dyes". Tetrahedron Letters 58 2 (2017): 159-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006511745&partnerID=MN8TOARS.
    10.1016/j.tetlet.2016.11.123
  16. Proença, C.; Freitas, M.; Ribeiro, D.; Oliveira, E.F.T.; Sousa, J.L.C.; Tomé, S.M.; Ramos, M.J.; et al. "a-Glucosidase inhibition by flavonoids: an in vitro and in silico structure–activity relationship study". Journal of Enzyme Inhibition and Medicinal Chemistry 32 1 (2017): 1216-1228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029757909&partnerID=MN8TOARS.
    Open access • 10.1080/14756366.2017.1368503
  17. Sousa, J.L.C.; Gomes, V.; Mateus, N.; Pina, F.; de Freitas, V.; Cruz, L.. "Synthesis and equilibrium multistate of new pyrano-3-deoxyanthocyanin-type pigments in aqueous solutions". Tetrahedron 73 41 (2017): 6021-6030. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028769468&partnerID=MN8TOARS.
    10.1016/j.tet.2017.08.051
  18. Sousa, J.L.C.; Silva, A.M.S.. "Microwave-assisted tandem reactions towards a new synthesis of cyclohepta[b]chromene-9,11-diones". Synlett 28 3 (2017): 316-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-85001754702&partnerID=MN8TOARS.
    10.1055/s-0036-1588116
  19. Sousa, J.L.C.; Proença, C.; Freitas, M.; Fernandes, E.; Silva, A.M.S.. "New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 119 (2016): 250-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969872335&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.04.057
  20. Sousa, J.L.C.; Talhi, O.; Mendes, R.F.; Almeida Paz, F.A.; Bachari, K.; Silva, A.M.S.. "Catalytic One-Pot Diastereoselective Michael-Initiated Ring-Closure of Methyl Ketones with 3-Bromochromones: Synthesis of Cyclopropa[b]chromanones". European Journal of Organic Chemistry 2016 23 (2016): 3949-3958. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982107341&partnerID=MN8TOARS.
    10.1002/ejoc.201600413
  21. Sousa, J.L.C.; Talhi, O.; Rocha, D.H.A.; Pinto, D.C.G.A.; Almeida Paz, F.A.; Bachari, K.; Kirsch, G.; Silva, A.M.S.. "One-Pot Synthesis of Novel Highly Functionalized Furan-Based Polyphenolics". Synlett 26 19 (2015): 2724-2729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947809630&partnerID=MN8TOARS.
    10.1055/s-0035-1560580
  22. Sousa, J.L.C.; Santos, I.C.M.S.; Simões, M.M.Q.; Cavaleiro, J.A.S.; Nogueira, H.I.S.; Cavaleiro, A.M.V.. "Iron(III)-substituted polyoxotungstates immobilized on silica nanoparticles: Novel oxidative heterogeneous catalysts". Catalysis Communications 12 6 (2011): 459-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649776279&partnerID=MN8TOARS.
    10.1016/j.catcom.2010.11.005
  23. Soares-Santos, P.C.R.; Cunha-Silva, L.; Sousa, F.L.; Sousa, J.L.C.; Gates, P.J.; Klinowski, J.; Trindade, T.; et al. "A new supramolecular organic-inorganic adduct: {[Eu(CH3OH) (H2O)8]2[Eu(H2O)8] [PW12O40]3}·8(C14H 20O5)·2(C28H40O 10)·6(CH3OH)·6(H2O)". Journal of Molecular Structure 989 1-3 (2011): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952190279&partnerID=MN8TOARS.
    10.1016/j.molstruc.2011.01.007
Thesis / Dissertation
  1. Silva, Artur Manuel Soares da; Sousa. Joana Lia Cardoso de. "Síntese de compostos heterocíclicos de oxigénio funcionalizados: avaliação da atividade antioxidante de derivados 3-hidroxilados". PhD, Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, 2016. http://hdl.handle.net/10773/19027.
  2. Nogueira, Helena Isabel Seguro; Cavaleiro, Ana Maria Vieira da Silva Viana; Sousa, Joana Lia Cardoso de. "Novos materiais contendo polioxometalatos suportados e sua aplicação em catálise oxidativa". Master, Universidade de Aveiro Departamento de Química, 2009. http://hdl.handle.net/10773/3100.
  3. Sousa, Joana L. C.. "Contribution to the synthesis of polyhydroxymethylated pyrrolidine derivatives as precursors of isoazahomonucleosides". Degree, Universidade do Porto Faculdade de Ciências, 2006.

Intellectual property

Provisional application for patent
  1. 2022. "Nitro-containing compounds, compositions and uses thereof".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07 Reactivity studies of 3-bromochromone derivatives in conjugate addition reactions 29th International Society of Heterocyclic Chemistry Congress (ISHC-2024)
(Aveiro, Portugal)
2024 Effects of solvent extraction on the chemical composition of Cannabis sativa inflorescence: a GC/MS analysis and antioxidant activity comparison 4th International Conference on Natural Products & Human Health (ICNPHH 2024)
(Aveiro, Portugal)
2024 Exploring the potential of Lycium chinense Mill. (goji) pruning waste: chemical properties and applications in food products Conference on Fruit Processing and By-products Valorization
(Aveiro, Portugal)
2024 Impact of solvents in modulating phytochemical composition and antioxidant activity of Cannabis sativa inflorescence extracts XXVIII Encontro Galego-Portugués de Química
(Vigo, Spain)
2023/11 Expanding the betulinic acid chemical space
(Porto, Portugal)
2023/07 Nitro group-containing compounds as histone deacetylase inhibitors
(Aveiro, Portugal)
2022 Betulinic acid as raw material to produce novel added-value compounds 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
(Lisboa, Portugal)
2022 Mild synthesis of nitrobenzenes from 3-formylchromones XXVI Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2017 MW-assisted synthesis of fused polycyclic compounds XXIII Encontro Galego-Portugués de Química
(Ferrol, Spain)
2017 Structure-related inhibition of protein tyrosine phosphatase 1B (PTP1B) by flavonoids 22nd International Congress on Prevention of Diabetes and Complications
(London, United Kingdom)
2015 3-Bromochromones as building blocks of novel furan and cyclopropane derivatives Congresso de Química Orgânica e Química Terapêutica
(Porto, Portugal)
2011 Polyoxometalates in silica nanoparticles: multifunctional core/shell materials XXII Encontro Nacional da Sociedade Portuguesa de Química
(Braga, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Exploring chromone derivatives as innovative cap groups in histone deacetylase 8 inhibitors
Co-supervisor of Ivo Cruz
 MSc in Biochemistry (Master)
Universidade de Aveiro, Portugal
2024 - Current Development of betulinic acid-based fluorescent probes for imaging living cells
Supervisor of Carolina Neri
 MSc in Chemistry (Master)
Universidade de Aveiro, Portugal
2024 - Current Development of antidiabetic agents based on betulinic acid derivatives
Supervisor of Mateus Moniz
 MSc in Biochemistry (Master)
Universidade de Aveiro, Portugal
2024/02 - 2024/07 Inhibition of a-glucosidase by betulonic acid-derived triphenylphosphonium salts
Supervisor of Mateus Moniz
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2024/02 - 2024/07 Development of natural product-based fluorescent probes for imaging living cells
Supervisor of Carolina Neri
 Química (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2024/02 - 2024/07 Analysis of phytochemicals and prospecting the antioxidant and anti-inflammatory potential of infusions of Lycium chinense leaves
Co-supervisor of Ana Varejão
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2024/02 - 2024/07 Goji pruning waste: potential application for added-value products
Co-supervisor of José Ribeiro
 Biotecnologia (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2023/11 - 2023/11 Synthesis, structural characterization and antioxidant activity of 1,4-benzoxazin-3-one- and 1,4-benzothiazin-3-one-type compounds
Co-supervisor of Sourour Tliba
 Postgraduate Traineeship in Chemistry (Other)
Universidade de Aveiro Departamento de Química, Portugal
2023/09 - 2023/09 Synthesis of trimethoprim derivatives
Co-supervisor of Hadjer Merazka
 Postgraduate Traineeship in Chemistry (Other)
Universidade de Aveiro, Portugal
2023/02 - 2023/07 Cationic diarylpyridine-fused betulinic acid hybrids as new epi-drugs for cancer therapy
Supervisor of André Pinto
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2023/02 - 2023/06 Revisiting the nitrobenzene scaffold for cancer therapy
Co-supervisor of Ivo Cruz
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2023/04 - 2023/05 Structural characterization of novel 2-pyridone and carbamate derivatives
Co-supervisor of Maamar Haffas
Universidade de Aveiro Departamento de Química, Portugal
2022/03 - 2022/07 Synthesis of aminopyridines as histone deacetylases inhibitors
Supervisor of Leonardo Matias
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2022/03 - 2022/07 Preliminary screening of potential histone deacetylases inhibitors. Structure-activity relationship profile of nitrobenzenes
Supervisor of Maria Grades
 Bioquímica (Degree)
Universidade de Aveiro Departamento de Química, Portugal
2022/01 - 2022/07 Synthesis of libraries of oxygen and nitrogen heterocyclic compounds, and study of their binding with DNMT and HDAC enzymes of cancer cells
Co-supervisor of Telmo Francisco
LAQV-REQUIMTE - Polo de Aveiro, Portugal

Universidade de Aveiro Departamento de Química, Portugal
2021/03 - 2021/07 Development of new epigenetic drugs for cancer therapy
Supervisor of Andreia Malafaia
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2019/02 - 2019/07 Synthesis of new antimicrobial agents based on the functionalization of betulinic acid derivatives
Supervisor of Rogério Almeida
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2017/10 - 2019/07 Post-modification of cyclopropa[b]chromanones bearing an a,ß-unsaturated carbonyl system towards the synthesis of new nitrogen heterocycle-containing hybrids
Co-supervisor of Nadia Bouhassane
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
2017/10 - 2019/03 Reactivity of 3-substituted chromone derivatives as dienes in Diels-Alder reactions under MW irradiation
Co-supervisor of Fatiha Nouali
Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
2018/02 - 2018/07 Synthesis and evaluation of the antioxidant activity of polyhydroxylated compounds derived from 28-oxoallobetulone
Supervisor of Cristiana Gonçalves
 Bioquímica (Degree)
Universidade de Aveiro, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/07/21 - 2024/07/26 29th International Society of Heterocyclic Chemistry Congress (ISHC-2024), 21-26 July 2024, University of Aveiro, Portugal, member of the local organizing committee. (2024/07)
Congress (Member of the Organising Committee)
 Universidade de Aveiro, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Chemical Biology and Drug Design (1747-0285) Wiley
2023 - Current Molbank (1422-8599) MDPI
2022 - Current International Journal of Molecular Sciences MDPI
2020 - Current Applied Sciences MDPI
2020 - Current Medicinal Chemistry Research (1554-8120) Springer-Verlag
2019 - Current Plants (2223-7747) MDPI AG
2019 - Current Molecules (1420-3049) MDPI AG
2018 - Current Journal of Chemistry Hindawi

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03 - Current Organic Chemistry Laboratory Licenciatura em Engenharia Química (Licenciatura) Universidade de Aveiro Departamento de Química, Portugal
2021/02 - 2021/07 General Chemistry Laboratory Licenciatura em Física (Licenciatura) Universidade de Aveiro Departamento de Química, Portugal
2021/02 - 2021/07 General Chemistry Laboratory Licenciatura em Geologia (Licenciatura) Universidade de Aveiro Departamento de Química, Portugal
Distinctions

Award

2018 Travel award (350$) to attend the 28th European Colloquium on Heterocyclic Chemistry (ECHC 2018) sponsored by IUPAC.
International Union of Pure and Applied Chemistry, United States
2011 Best poster award in the "VIII Jornadas do CICECO" with the communication entitled "Polyoxometalates in silica nanoparticles: multifunctional core/shell materials".
Universidade de Aveiro CICECO, Portugal
2010 Participation grant (85Eur) in the 2nd Portuguese Young Chemists Meeting (2PYCheM) sponsored by Hovione.
Hovione, Portugal