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Organic chemistry | Medicinal chemistry | Toxicology Sara got her Bachelor's (2016) and Master's (2018) degree in Chemistry from Faculty of Sciences of the University of Porto. She got her PhD (2024) in Sustainable Chemistry from Faculty of Science, University of Porto. All the academic and professional career was focused in the areas of Organic Chemistry and Medicinal Chemistry. It is worth noting the receipt of a prize related to Organic Chemistry, which served as recognition of all the dedication to this area of chemistry. She was always interested in finding new therapies related to Neurodegenerative diseases.
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Identification

Personal identification

Full name
Sara Carolina Silva Reis

Citation names

  • Sara C. Silva-Reis

Author identifiers

Ciência ID
7B11-9434-10B1
ORCID iD
0000-0003-2024-0696

Email addresses

  • sarac.silva-reis@hotmail.com (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2020/01/01 - 2024/06/14
Concluded
 Sustainable Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"NeuroPro: peptide conjugates for Neurodegenerative diseases using constrained Prolines." (THESIS/DISSERTATION)
2020 - 2022
Concluded
 PhD course in Sustainable Chemistry (Curricular Units) (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
 18 out of 20
2016/09/19 - 2018/10/26
Concluded
 Chemistry (Mestrado)
Major in Organic Chemistry
Universidade do Porto Faculdade de Ciências, Portugal
"Síntese e Avaliação biológica de conjugados lipofílicos do GPE com aminas neuroprotetoras." (THESIS/DISSERTATION)
 18 out of 20
2018/10/01 - 2018/10/13
Concluded
 Cell Culture (Outros)
Escola Portuguesa de Oncologia do Porto, Portugal
 Approved
2017/02/01 - 2017/07/31
Concluded
 PEEC-Extracurricular Internship Program (Outros)
Major in Química Orgânica / Síntese Peptídica Em Solução
Universidade do Porto Faculdade de Ciências, Portugal
 5 out of 5
2016/02/01 - 2016/07/31
Concluded
 PEEC-Extracurricular Internship Program (Outros)
Major in Química Orgânica / Síntese assimétrica
Universidade do Porto Faculdade de Ciências, Portugal
 5 out of 5
2013/09/16 - 2016/07/15
Concluded
 Chemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Síntese de derivados do Ácido glicil-L-prolil-L-glutâmico como potenciais agentes terapêuticos neuroprotetores " (THESIS/DISSERTATION)
 15 out of 20
2015
Concluded
 Introduction to Legal Medicine (Outros)
Universidade do Porto Faculdade de Direito, Portugal
 Approved
Affiliation

Science

Category
Host institution 		Employer
2024/05 - Current Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2020/01 - 2024 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/12 Research Trainee (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projects

Grant

Designation Funders
2020/01/01 - Current NeuroPro: peptide conjugates for Neurodegenerative diseases using constrained Prolines.
SFRH/BD/147463/2019
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/01 - 2019/12/31 BaITS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke
POCl-01-0145-FEDER-016639
Research Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022 - Current DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy
2022.01175.PTDC
Researcher
REQUIMTE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Instituto para a Saúde e a Bioeconomia
LA/P/0140/2020
10.54499/LA/P/0140/2020
PhD Student Fellow
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2024/06/30 DynaPro: Avaliação da Quiralidade Dinâmica no Resgate da Melanostatina na Terapia do Parkinson
2022.01175.PTDC
10.54499/2022.01175.PTDC
Universidade de Santiago de Compostela Facultade de Farmacia, Spain

Universidad del País Vasco, Spain

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Unidade de Ciências Biomoleculares Aplicadas
UIDB/04378/2020
10.54499/UIDB/04378/2020
PhD Student Fellow
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Unidade de Ciências Biomoleculares Aplicadas
UIDP/04378/2020
10.54499/UIDP/04378/2020
PhD Student Fellow
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Associated Laboratory for Green Chemistry - Clean Technologies and Processes
UID/QUI/50006/2019
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Joana P. Oliveira; Sara C. Silva-Reis; Daiane Maronde; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Vera M. Costa; Ivo E. Sampaio-Dias. "Probing the Assembly of Fluorescent Glypromate-Based Conjugates". Paper presented in XVII Meeting of Young Researchers of the University of Porto (IJUP), 2024.
  2. Hugo F. Costa-Almeida; Sara C. Silva-Reis; Correia, Xavier Cruz; Vera M. Costa; Daniela Correia da Silva; David M. Pereira; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Synthesis and Biological Evaluation of Novel Glypromate Conjugates with Bioactive Amines for Application in Neurodegenerative Diseases". Paper presented in XVII Meeting of Young Researchers of the University of Porto (IJUP), 2024.
  3. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis and structural analysis of cyclic aza-amino acid derivatives for the assembly of azapeptides". Paper presented in 15th National Organic Chemistry Meeting | 8th National Medicinal Chemistry Meeting, 2024.
  4. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Daniela Correia da Silva; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Vera M. Costa; et al. "Exploring the biological impact of proline residue on Glypromate bioconjugates". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, 2023.
  5. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Reis-Mendes, Ana; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Application of 2-Azanorbornane for the Assembly of Bioactive Peptidomimetics". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, 2023.
  6. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Ivo E. Sampaio-Dias. Corresponding author: Beatriz L. Pires-Lima. "N-Hydroxylation of Melanostatin Neuropeptide by Cope Elimination". Paper presented in Ciência 2023, 2023.
  7. Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Sara C. Silva-Reis. "New Neuropeptide-Based Constrained Analogs for Alzheimer's and Parkinson's Diseases.". Paper presented in Ciência 2023, 2023.
  8. Correia, Xavier Cruz; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Exploring the Effect of Amide-to-Semicarbazide Replacement in Melanostatin Neuropeptide". Paper presented in IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  9. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Pyridine-Based Melanostatin Bioisosteres as Positive Allosteric Modulators of the Dopamine D2 Receptors". Paper presented in IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  10. Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Correia, Xavier Cruz; Beatriz L. Pires-Lima; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Exploring the Impact of Proline Puckering in the Modulatory Activity of Melanostatin Neuropeptide". Paper presented in IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  11. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Vera M. Costa; Daniela Correia da Silva; David M. Pereira; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; et al. "Unraveling the Role of Proline on the Biological Activity of Glypromate Bioconjugates". Paper presented in IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  12. Henrique R. Rodrigues; Joana P. Oliveira; Xavier C. Correia; Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Ivo E. Sampaio-Dias. "Exploring the synthesis of activated aza-proline and aza-pipecolic acid and their structural analysis by X-ray crystallography". Paper presented in XVI Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  13. Joana P. Oliveira; Henrique R. Rodrigues; Xavier C. Correia; Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Ivo E. Sampaio-Dias. "Application of aza-proline-based scaffolds for the assembly of Glypromate analogues". Paper presented in XVI Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  14. Xavier C. Correia; Sara C. Silva-Reis; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Ivo E. Sampaio-Dias. "On-Site N-Hydroxylation of Proline-Containing Peptides". Paper presented in ENEQUI - Encontro Nacional de Estudantes de Química, 2023.
  15. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Xavier C. Correia; Costa-Almeida, Hugo F.; Vera M. Costa; García-Mera, Xerardo; José E. Rodríguez-Borges; Ivo E. Sampaio-Dias. "Using Proline Bioisosteres for the Assembly of Potent Melanostatin (MIF-1) Analogues". Paper presented in ENEQUI - Encontro Nacional de Estudantes de Química, 2023.
  16. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; da Silva, Daniela Correia; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera Marisa; et al. Corresponding author: Sara C. Silva-Reis. "Discovery of Glypromate Conjugates with Biomedical Applications in Alzheimer's Disease". Paper presented in 2nd Symposium on Alzheimer's Disease, 2023.
  17. Maronde, DAIANE; Sara C. Silva-Reis; Xavier C. Correia; Hugo F. Costa-Almeida; Beatriz L. Pires-Lima; Vera M. Costa; Xerardo García-Mera; José E. Rodríguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Exploring The Lipophilic Bullet Approach In Melanostatin Neuropeptide". Paper presented in IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  18. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Beatriz L. Pires-Lima. "Pyridine-Based Melanostatin Bioisoteres As Positive Allosteric Modulators Of The Dopamine D2 Receptors". Paper presented in IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  19. Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Correia, Xavier Cruz; Beatriz L. Pires-Lima; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Costa-Almeida, Hugo F.. "Exploring The Impact Of Proline Puckering On The Modulatory Activity Of Melanostatin Neuropeptide". Paper presented in IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  20. Luciano Eduardo Rodrigues dos Santos; Ivo E. Sampaio-Dias; Renata Santana; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Macrocyclization of Melanostatin Neuropeptide by Ring-Closing Metathesis". Paper presented in XV Meeting of Young Researchers of University of Porto (IJUP'22), 2022.
  21. Renata Santana; Ivo E. Sampaio-Dias; Luciano Eduardo Rodrigues dos Santos; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "A New Methodology for the Synthesis of N-functionalized Glycines: Assembly of Melanostatin-Based Peptoids". Paper presented in XV Meeting of Young Researchers of University of Porto (IJUP'22), 2022.
  22. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Sara C. Silva-Reis. "Application of Hybrid Glypromate® Conjugates in Neurodegenerative Diseases". Paper presented in Encontro Ciência 2022, 2022.
  23. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Sara C. Silva-Reis. "Peptide-amine Conjugates targeting Neurodegenerative Diseases". Paper presented in XX National Meeting of the Spanish Society of Medicinal Chemistry (SEQT), 2022.
  24. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Sara C. Silva-Reis. "Design, Synthesis, and Biological Evaluation of Glypromate-Based Neuroprotective Conjugates with Pharmaceutical Active Ingredients". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  25. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "Discovery of Neuroprotective Hits Using 2-Azanorbornane as a Constrained Proline Surrogate in Glypromate Neuropeptide". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  26. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Xavier C. Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the bioisosterism of proline residue in melanostatin neuropeptide using heteroaromatic scaffolds.". Paper presented in 7th International Electronic Conference on Medicinal Chemistry., 2021.
  27. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Beatriz L. Pires-Lima; Xavier C. Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges; et al. Corresponding author: Sara C. Silva-Reis. "The Design of New Trofinetide® Conjugates Using Constrained Prolines.". Paper presented in XXVII Encontro Nacional da Sociedade Portuguesa de Química., 2021.
  28. Hugo F. Costa-Almeida; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Xavier C. Correia; García-Mera, Xerardo; J. E. Rodriguez-Borges; et al. Corresponding author: Ivo E. Sampaio-Dias. "Assembly of Melanostatin Peptidomimetics Using Chiral ß-Amino Acids as Proline Surrogates.". Paper presented in IJUP., 2021.
  29. Beatriz L. Pires-Lima; Xavier C. Correia; Hugo F. Costa-Almeida; Sara C. Silva-Reis; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias; et al. Corresponding author: Ivo E. Sampaio-Dias. "Replacement of Proline residue in Melanostatin Neuropeptide by chiral and achiral scaffolds: a Bioisosteric approach.". Paper presented in VI Jornadas da Bioquímica., 2021.
  30. Hugo F. Costa-Almeida; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Xavier C. Correia; García-Mera, Xerardo; J. E. Rodriguez-Borges; et al. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the Synthesis and Pharmacological Evaluation of Melanostatin (MIF-1) Peptidomimetics Bearing Chiral ß-Amino Acids as Proline Surrogates.". Paper presented in Digital Colloquium 2021., 2021.
  31. Beatriz L. Pires-Lima; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Xavier C. Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges; et al. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the role of Proline's Secondary Amine on Melanostatin (MIF-1) Neuropeptide using a Bioisosteric Approach.". Paper presented in Digital Colloquium 2021., 2021.
  32. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Beatriz L. Pires-Lima; Xavier C. Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges; et al. Corresponding author: Sara C. Silva-Reis. "NeuroPro: An Innovative Approach for the Assembly of New Neuroprotective Conjugates.". Paper presented in Digital Colloquium 2021., 2021.
  33. Correia, Xavier Cruz; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges; et al. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the Assembly of Melanostatin (MIF-1) Aza-Peptidomimetics". Paper presented in Digital Colloquium, 2021.
  34. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; Cristina Alcoholado; Algarra, Manuel; García-Mera, Xerardo; et al. Corresponding author: Ivo E. Sampaio-Dias. "Probing Constrained Prolines for the Assembly of Neuroprotective Glypromate® Peptidomimetics". Paper presented in RICT – 56th International Conference on Medicinal Chemistry (Interfacing Chemical Biology and Drug Discovery), 2021.
  35. Correia, Xavier Cruz; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges; et al. Corresponding author: Ivo E. Sampaio-Dias. "Using aza-Proline for the Assembly of a Melanostatin aza-Peptide Derivative". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  36. Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Correia, Xavier Cruz; García-Mera, Xerardo; José Enrique Rodriguez Borges; Ivo E. Sampaio-Dias; et al. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis and Pharmacological Evaluation of Melanostatin Analogues Containing Chiral ß-Amino Acids as Proline Surrogates". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  37. Correia, Xavier Cruz; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Correia, Xavier Cruz. "Exploring the Synthesis and Pharmacological Evaluation of Melanostatin (MIF-1) Peptidomimetics Bearing Chiral ß-Amino Acids as Proline Surrogates. Digital Colloquium 2021, 2021, March 26-28th, online. - Xavier C. Correia; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Hugo F. Costa-Almeida; Xerardo García-Mera; José E. Rodríguez-Borges. Exploring the Assembly of Melanostatin (MIF". Paper presented in Digital Colloquium 2021, 2021.
  38. Beatriz Lopes P. Lima; Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Xerardo García-Mera; José E. Rodríguez-Borges. "Synthesis, pharmacological, and biological evaluation of pyridine-based MIF-1 peptidomimetics as positive allosteric modulators of D2R". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  39. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Sara C. Silva-Reis. "Rescuing of Neuroprotective Peptides by Chemical Conjugation with Lipophilic Active Pharmaceutical Ingredients.". Paper presented in The 6th International Electronic Conference on Medicinal Chemistry (ECMC 2020)., 2020.
  40. Custódio, Beatriz; Natália Magalhães; Joana F Marques; Sara C. Silva-Reis; Pedro Mota; Victoria Leiro; José Bessa; Santos, Sofia Duque; Ana Paula Pêgo. "The blood-brain barrier as a challenge to face in the delivery of nucleic acids mediated by dendrimers in brain ischemia". Paper presented in 8th i3S Annual Meeting, Póvoa do Varzim, 2019.
  41. Sara C. Silva-Reis; Mota, P.; Pêgo, Ana Paula; Victoria Leiro. "Innovative Biodegradable Dendrimers to act as Novel Nanocarriers for Nucleic Acids Delivery – Design and Synthesis Approaches". Paper presented in 8th i3S Annual Meeting, 2019.
  42. Pedro Mota; Sara C. Silva-Reis; Pêgo, Ana Paula; Victoria Leiro. "Scale-up synthesis of PEG-dendrimers to act as nucleic acids vectors". Paper presented in 8th i3S Annual Meeting, 2019.
  43. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; José E. Rodríguez-Borges. "Synthesis, Pharmacological and Biological Evaluation of PLG Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2 Receptors". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  44. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Liz, Márcia Almeida; José Enrique Rodríguez Borges. "Development of New GPE Conjugates with Potentially Synergistic Properties (Desenvolvimento de Novos Conjugados do GPE com Propriedades Potencialmente Sinérgicas)". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  45. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; José E. Rodríguez-Borges. "Preparation of enantiomerically pure forms of 2-azanorbornane-3-exo-carboxylic acid through asymmetric aza-Diels-Alder reactions (Preparação das formas enantiomericamente puras do ácido 2-azanorbornano-3-exo-carboxílico através de reacções de aza-Diels-Alder assimétricas)". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  46. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges. "Preparação das formas enantiomericamente puras do ácido 2-azanorbornano-3-exo-carboxílico através de reações de aza-Diels-Alder assimétricas". Paper presented in XXIV Encontro Luso-Galego de Química., 2018.
  47. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges. "Desenvolvimento de Novos Conjugados do GPE com Propriedades Potencialmente Sinérgicas". Paper presented in XXIV Encontro Luso-Galego de Química., 2018.
  48. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; J. E. Rodriguez-Borges. "One-Pot Assembly of Oligopeptides in Solution-Phase". Paper presented in 35th European Peptide Symposium, 2018.
  49. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Jéssica Eira; Márcia Raquel Pereira de Almeida e Liz; J. E. Rodriguez-Borges. "Development of New GPE Conjugates with Application in Neurodegenerative Diseases". Paper presented in III Encontro Biotecnologia Medicinal /1st Iberian Congress on Medicinal Biotechnology., 2018.
  50. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Development of a Highly Efficient One-pot Protocol for the Synthesis of Oligopeptides in Solution-Phase". Paper presented in 16th Iberian Peptide Meeting (16EPI) / 4th Chemical Biology Group Meeting (4GEQB)., 2018.
  51. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Jéssica Eira; Márcia Raquel Pereira de Almeida e Liz; J. E. Rodriguez-Borges. "Synthesis and Evaluation of GPE lipophilic conjugates with neuroprotective amines". Paper presented in IJUP – Encontro de Investigação Jovem da Universidade do Porto., 2018.
  52. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Jéssica Eira; Márcia Raquel Pereira de Almeida e Liz; J. E. Rodriguez-Borges. "Exploring the potential synergic effect of GPE lipophilic conjugates with neuroprotective amines". Paper presented in 12º ENQO / 5º ENQT – 12º Encontro nacional de Química Orgânica / 5º Encontro de Química Terapêutica., 2018.
  53. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Greener Approach for the Synthesis of Oligopeptides in Solution-Phase". Paper presented in 12º ENQO / 5º ENQT – 12º Encontro nacional de Química Orgânica / 5º Encontro de Química Terapêutica., 2018.
  54. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges. "Synthesis of Lipophilic Glycyl-L-Prolyl-L-Glutamic acid (GPE) derivatives as potential neuroprotective therapeutic agents". Paper presented in IJUP - 10º Encontro de Investigação Jovem, 2017.
Journal article
  1. Sara C. Silva-Reis; Costa, Vera Marisa; da Silva, Daniela Correia; Pereira, David; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Exploring Structural Determinants of Neuroprotection Bias on Novel Glypromate Conjugates with Bioactive Amines". European Journal of Medicinal Chemistry (2024):
    Accepted
  2. Sara C. Silva-Reis; Xavier C. Correia; Hugo F. Costa-Almeida; Beatriz L. Pires-Lima; Daiane Maronde; Vera M. Costa; Xerardo García-Mera; et al. Corresponding author: Ivo E. Sampaio-Dias. "Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors". ACS Medicinal Chemistry Letters (2023): https://doi.org/10.1021/acsmedchemlett.3c00264.
    Published • 10.1021/acsmedchemlett.3c00264
  3. Sara C. Silva-Reis; Sampaio-Dias, Ivo E.; Costa, Vera M.; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; Rodríguez-Borges, José E.. Corresponding author: Sampaio-Dias, Ivo E.. "Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences". ACS Chemical Neuroscience (2023): http://dx.doi.org/10.1021/acschemneuro.2c00675.
    Published • 10.1021/acschemneuro.2c00675
  4. Sampaio-Dias, Ivo E.; Silva-Reis, Sara C.; Pires-Lima, Beatriz L.; Correia, Xavier Cruz; Costa-Almeida, Hugo F.. "A Convenient On-Site Oxidation Strategy for the N-Hydroxylation of Melanostatin Neuropeptide Using Cope Elimination". Synthesis 54 08 (2022): 2031-2036. http://dx.doi.org/10.1055/a-1695-1095.
    Published • 10.1055/a-1695-1095
  5. Sampaio-Dias, Ivo E; Sousa, Carlos A. D.; Silva-Reis, Sara C.; Pinto da Silva, Luís; Garcia-Mera, Xerardo; Rodriguez-Borges, José Enrique. "Isolation and Structural Characterization of Stable Carbamic-Carbonic Anhydrides: An Experimental and Computational Study". Organic Chemistry Frontiers (2022): http://dx.doi.org/10.1039/d2qo00038e.
    Published • 10.1039/d2qo00038e
  6. Ivo E. Sampaio-Dias; Miguel Santejo; Sara C. Silva-Reis; Márcia A. Liz; Cristina Alcoholado; Manuel Algarra; Xerardo García-Mera; et al. Corresponding author: Ivo E. Sampaio-Dias. "Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate". ACS Chemical Neuroscience (2021): https://doi.org/10.1021/acschemneuro.1c00339.
    Published • 10.1021/acschemneuro.1c00339
  7. Spencer, Ana P.; Torrado, Marília; Custódio, Beatriz; Sara C. Silva-Reis; Santos, Sofia D.; Leiro, Victoria; Pêgo, Ana P.. "Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System". Pharmaceutics 12 2 (2020): 192. http://dx.doi.org/10.3390/pharmaceutics12020192.
    Published • 10.3390/pharmaceutics12020192
  8. Sara C. Silva-Reis; Ana C. V. D. Santos; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Bioinspired Design for the Assembly of Glypromate® Neuropeptide Conjugates with Active Pharmaceutical Ingredients". New Journal of Chemistry (2020):
    Published • 10.1039/D0NJ04851H
  9. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; Brea, José; Loza, M. Isabel; Alves, Carla S.; Algarra, Manuel; J. E. Rodriguez-Borges. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R". ACS Chemical Neuroscience 10 8 (2019): 3690-3702. http://dx.doi.org/10.1021/acschemneuro.9b00259.
    Published • 10.1021/acschemneuro.9b00259
  10. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Pinto da Silva, Luís; García-Mera, Xerardo; Maestro, Miguel A.; J. E. Rodriguez-Borges. Corresponding author: Ivo E. Sampaio-Dias. "Mechanistic insights for the transprotection of tertiary amines with Boc2O via charged carbamates: access to both enantiomers of 2-azanorbornane-3-exo-carboxylic acids". Organic Chemistry Frontiers 6 20 (2019): 3540-3554. http://dx.doi.org/10.1039/c9qo00957d.
    Published • 10.1039/c9qo00957d
  11. Ivo E. Sampaio-Dias; Carlos A. D. Sousa; Sara C. Silva-Reis; Sara Ribeiro; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Highly efficient one-pot assembly of peptides by double chemoselective coupling". Organic & Biomolecular Chemistry 15 36 (2017): 7533-7542. http://dx.doi.org/10.1039/c7ob01544e.
    Published • 10.1039/c7ob01544e
Thesis / Dissertation
  1. Faculdade de Ciências. "Síntese e Avaliação Biológica de Conjugados Lipofílicos do Ácido Glicil-L-Prolil-L-Glutâmico com Aminas Neuroprotetoras". Master, Universidade do Porto Faculdade de Ciências, 2018. http://hdl.handle.net/10216/116701.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 Insights on the Influence of Proline Residue on the Biological Effects of Glypromate Bioconjugates. EPI 2023 – XVIII Iberian Peptide Meeting
(Sesimbra, Portugal)
2023/11 Synthesis of pyridine-based melanostatin derivatives EPI – XVIII Iberian Peptide Meeting
(Sesimbra, Portugal)
2023/07 Exploring the biological impact of proline residue on Glypromate bioconjugates. MedChem 2023
(Thessaloniki, Greece)
2023/07 Exploring stereodynamic effects on Melanostatin neuropeptide MedChem 2023
(Thessaloniki, Greece)
2023/06 Exploring The Effect Of Amide-To-Semicarbazide Replacement In Melanostatin Neuropeptide. IX Symposium of Medicinal Chemistry Young Researchers
(Santiago de Compostela, Spain)
2023/05 Probing (tri)phosgene-free assembly of semicarbazides in aza-peptide synthesis XVI Meeting of Young Researchers of University of Porto (IJUP'23)
(Porto, Portugal)
2023/05 Tackling Parkinson’s Disease by Modulation of Dopamine Receptors Using Chiral Non-Proteinogenic Melanostatin Analogs XVI Meeting of Young Researchers of University of Porto (IJUP'23)
(Porto, Portugal)
2023/04 Effective Peptide-Based Conjugates for Application in Central Nervous System Disorders ENEQUI - Encontro Nacional de Estudantes de Química
(Porto, Portugal)
2023/04 Synthesis and Biological Evaluation of a Potent Melanostatin Analogs with Application in Parkinson's Disease ENEQUI - Encontro Nacional de Estudantes de Química
(Porto, Portugal)
2023/02 Glypromate Conjugates for Application in Neurodegenerative Diseases SPF Meeting 2023
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2023 Exploring Proline's Puckering Effect On The Allosteric Modulatory Activity Of Melanostatin Neuropeptide SIFFUP – Simpósio de Investigação da FFUP 2023
(Porto, Portugal)
2022/11 Synthesis, Pharmacological and Toxicological Evaluation of Potent Melanostatin Peptidomimetics Incorporating Chiral ß-Amino Acids as Proline Surrogates 8th International Electronic Conference on Medicinal Chemistry
2022/11 Uma Abordagem Bioisostérica na Descoberta de Potentes Análogos da Melanostatina Usando ß-Aminoácidos XXVI Encontro Galego-Portugués de Química
(Spain)
2022/11 Discovery of Melanostatin-Based Potent Modulators of the Dopamine D2 Receptors Using Furoic Acids as Proline Surrogates XXVI Encontro Galego-Portugués de Química
(Spain)
2022/11 Melanostatin Aza-Peptides as Potent Allosteric Modulators of the Dopamine D2 Receptors XXVI Encontro Galego-Portugués de Química
(Spain)
2022/11 Synthesis, Pharmacological and Toxicological Evaluation of Melanostatin-Based Peptidomimetics to Tackle Parkinson’s Disease Simpósio de Investigação da Faculdade de Fármacia da Universidade do Porto
(Portugal)
2022/11 A Biodisosteric Approach in the Research of Potent Melanostatin Analogs Using Alicyclic Beta-Amino Acids Invited Lecture at ComBioMed Research Group
(Spain)
2022 Synthesis and Pharmacological Evaluation of Melanostatin Peptidomimetics using ß-Amino Acids as Proline Surrogates with Application in Parkinson’s Disease XV Meeting of Young Researchers of University of Porto (IJUP'22)
(Portugal)
2022 Thiophene-Based Melanostatin (MIF-1) Neuropeptide Analogues by O-to-S Bioisosteric Replacement in MIF-1 Furoyl Peptidomimetics XV Meeting of Young Researchers of University of Porto (IJUP'22)
(Portugal)
2022 A Chemical Strategy to Improve Bioavailability of Glypromate Peptide-Conjugates 8th International Electronic Conference on Medicinal Chemistry
2021/11 Constrained Glypromate® Analogues Incorporating a Bicyclic Proline Surrogate. 7th International Electronic Conference on Medicinal Chemistry.
2021/09 Exploring a biodegradable dendrimer as carrier of neuroprotective mRNA to reach the ischemic brain. 31st Conference of the European Society for Biomaterials.
2021/07 Probing Heteroaromatic Scaffolds in the Melanostatin Neuropeptide: A Bioisosteric Approach Using Niacin as a Pro Surrogate. XXVII Encontro Nacional da Sociedade Portuguesa de Química.
2021/06 Designing a new neurotargeted dendritic nanoparticle for nucleic acid delivery. DCE21 – Doctoral Congress in Engineering.
2021/05 A Bioisosteric Approach using Aza-Proline (azPro) as a Proline Surrogate in Melanostatin Neuropeptide. XVI Meeting of Young Researchers of University of Porto (IJUP'21)
(Porto, Portugal)
2021/05 Exploring the Role of the N-terminal Secondary Amine in Melanostatin Neuropeptide: A Bioisosteric Approach using (S)-Tetrahydro-2-furoic Acid as a Proline Surrogate. XVI Meeting of Young Researchers of University of Porto (IJUP'21)
(Porto, Portugal)
2021/03 Synthesis and Pharmacological Evaluation of Novel Melanostatin (MIF-1) Peptidomimetics Using 2-Furoic Acid as a Proline Surrogate. Digital Colloquium 2021.
2019/07 From Peripheral to Central Nervous System: A Journey Towards Targeted Neuronal Delivery. IDS11 - 11th International Dendrimer Symposium.

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/02 - 2024/07 Synthesis and Biological Evaluation of New Fluorescent Probes for Neurological Disorders
Co-supervisor of Joana Pinto de Oliveira
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07 Synthesis of Non-Proteinogenic Amino Acids for Application in Neurological Disorders
Co-supervisor of Joana Pinto de Oliveira
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07 Synthesis of Non-Proteinogenic Amino Acids for Application in Neurological Disorders
Co-supervisor of Henrique da Rocha Rodrigues
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/01 - 2023/07 Incorporation of 4-Fluoroprolines in Melanostatin and Glypromate Neuropeptides to Study the Proline Puckering Effect on Bioactivity
Co-supervisor of André Daniel Malta Aires Melo da Cruz
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Faculdade de Ciências da Universidade do Porto, Portugal
2022/09 - 2022/12 Incorporation of 4-Fluoroprolines in Melanostatin and Glypromate Neuropeptides to Study the Proline Puckering Effect on Bioactivity
Co-supervisor of André Daniel Malta Aires Melo da Cruz
 Formação em Contexto de Trabalho (Scientific initiation)
Faculdade de Ciências da Universidade do Porto, Portugal
2022/02 - 2022/07 Synthesis of Racetams for Application in Neurological Disorders
Co-supervisor of António Xavier Viera da Costa e Cruz Correia
 Extracurricular Internship Program (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2022/07 Synthesis of Azapeptidomimetics with Potential Anti-Parkinson Activity
Co-supervisor of Bruno Filipe Oliveira Magalhães
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Faculdade de Ciências da Universidade do Porto, Portugal
2021/07 - 2022/07 Synthesis and Biological Evaluation of Melanostatin Aza-Derivatives
Co-supervisor of Bruno Filipe Oliveira Magalhães
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Faculdade de Ciências da Universidade do Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - 2022 Reviewer of the submitted work at Planning and Obtaining Active Substances Curricular Unit of Pharmaceutical Chemistry Master course (Modeladores Alostéricos Positivos dos Recetores de Dopamina D2:Fundamentos da Síntese Peptídica, Elucidação Estrutural, Farmacologia e Toxicologia).
Evaluator
 Universidade do Porto Faculdade de Farmácia, Portugal
2022 - 2022 Reviewer of the submitted work at Seminar Curricular Unit of Pharmaceutical Chemistry Master course (From synthesis to pharmacology: an overview on melanostatin peptidomimetics as allosteric modulators of the dopamine D2 receptors).
Evaluator
 Universidade do Porto Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2023/12 - Current Heliyon (2405-8440) Elsevier

Mentoring / Tutoring

Topic Student name
2018 - 2018 Synthesis of Novel Inhibitors of HIV Protease Based on Darunavir Scaffold Pedro Moreira
2017 - 2018 Synthesis and Evaluation of Darunavir Analogues Based on 2-Furoic Acid António Xavier Vieira da Costa e Cruz
2017 - 2018 Synthesis and Evaluation of Darunavir Analogues Based on 3-(2-Furyl)acrylic acid Guilherme Leal Martinho da Rocha
2016 - 2017 Synthesis of PLG Peptidomimetics Mónica Marques
2016 - 2017 Methodology for N-propargylation via Reductive Amination Catarina Pontes
2016 - 2017 Synthesis and Biological Evaluation of GPE Conjugates with Potential Neuroprotective Activity Ana Catarina Vieira Dias dos Santos
Distinctions

Award

2022 Best Oral Communication - Simpósio de Investigação
Universidade do Porto Faculdade de Farmácia, Portugal
2016 Doutor Fernando Serrão (Organic Chemistry)
Universidade do Porto Faculdade de Ciências, Portugal

Other distinction

2021 Best Poster in Chemistry
IJUP, Portugal
2021 Best Oral Communication in Chemistry
IJUP, Portugal
2019 PhD scholarship
Fundação para a Ciência e a Tecnologia, Portugal