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Fatima Nogueira FN is a Principal Investigator at Medical Parasitology UNIT, IHMT-NOVA. Graduated in Molecular Microbiology and Genetics from the University of Lisbon in 1996, she obtained a Master in Medical parasitology at IHMT-NOVA in 2001 and a PhD in Biomedical Sciences, specialty of Medical Parasitology in the same University in 2007. Her main research interests are the antimalarial drug resistance mechanisms and targets; Search for synthetic and natural compounds as new antimalarials; Development of molecular tools for monitoring drug resistance in Plasmodium spp. IHMT-NOVA tasks coordinator of the projects: CIRCNA/BRB/0281/2019_AMAZING; EuroNanoMed3-NANOpheles ref. 171129_ERA-Net_NANOpheles; COMPETE2020. SAICT/2019. REF:46871v; 2022.02426.PTDC; PTDC/MEDQUI/30021/2017; PTDC/BTM-SAL/29786/2017; PTDC/SAU-FAR/114864/2009 CRI and PTDC/QUI/65142/2006 and team member of EDCTP-RegNet2015-1049; Erasmus+ Programme. 586245-EPP-1-2017-1-FR-EPPKA2-CBHE-JP; PTDC/BIA-CEL/28456/2017; VIASEF FCT/P2020, FEDER.n.º2207 and PTDC/SAU-MET/110323/2009. CYTED REF: P215RT0054; CYTED REF: Red 210RT0398. As a PhD student participated in CORDIS/ EU. REF: QLK2-CT-2002-01503; FCT. POCTI/FCB/39218/2001; FCG contrato nº 65472; POCTI/ESP/39580/2001; POCTI/ESP/42666/2001; PRAXIS/P/SAU/14070/98; PRAXIS/PSAU/P/SAL/38/96; FCG contrato nº 54965; POCTI/MGI/36369/1999; PRAXIS/3.1/AdI/L1347. Holds 2 patents (https://novainnovation.unl.pt/2022/06/21/antimalarial-agent-methods-and-uses-thereof/; (https://novainnovation.unl.pt/2022/06/30/anti-infective-pyrazino-12-bquinazoline-36-diones-derivatives-and-their-production/). Integrated member of GHTM (UID/04413/2020) and LA-REAL (LA/P/0117/2020) and a collaborator member of LAQV-REQUIMTE (UIDB/50006/2020 I&D Unit). Scientific program evaluator of EU (Expert EX2016D276705) INFRAIA-01-2016-2017 and INFRAIA-02-2017 and of the Ministry of Higher Education, Science, Technology and Innovation of Angola 2020. Technical-scientific support (advisor) of: i) Molecular Biology Laboratory of Lubango Central Hospital (LBM-HCL), Angola since 2022; and ii) Medical Entomology Laboratory (LEM) of the National Institute of Public Health of Cape Verde (INSP) from 2018-2023. Editor in the Anti-Infective Agents section of Frontiers in Drug Design and of Discovery and Molecular Sciences: Molecular Pharmacology . Over the years, and has been contributing with peer review for more than 24 Journals. Co-authored over 106 papers in internationally indexed scientific journals, (69 indexed in SCOPUS) in the fields of malaria drug resistance and new antimalarials, with over 1000 citations and an h-index of 21 (SCOPUS database assessed 14/02/24). FN is a member of RSTMH (nº 0023123) and ASM (ID: 200343879; and a member of the ASM Subcommittee for Career Development Grant for Postdoctoral Women (CDGPW). Regularly maintains field research collaboration&training with CPLP countries (São Tomé and Principe, East Timor, Cape Verde, Angola, Mozambique and Brazil), Senegal and Thailand. Scientific advisory board member of the PhD program "Global Health and Infectious Diseases" at IHMT. Coordinates 4 curricular units (2 PhD and 2 MsC) and teaches in 2 PhD and 5 MSc programs at IHMT-NOVA. Supervisor of 10 PhD students (6 ongoing (Clemente Silva (Millenium BCP grant, Valéria Chicamba, FCG grant, Denise Duarte FCT 2022.12736.BD, Inês Morais FCT 2023.03356.BD, Mbueno Nzila, Rafael Dimbu, and 4 completed) and 26 MSc students (22 completed, 4 ongoing).
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Identification

Personal identification

Full name
MARIA DE FÁTIMA CARVALHO NOGUEIRA
Gender
Female

Citation names

  • nogueira, fatima
  • nogueira F

Author identifiers

Ciência ID
7B1B-1ABB-1A16
ORCID iD
0000-0003-0313-0778
Researcher Id
I-2148-2012
Scopus Author Id
7006748317

Telephones

Telephone
  • 213652626 Ext.: 361 (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Parasitology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
French Upper intermediate (B2) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2007
Concluded
 DOUTORAMENTO (Doutoramento)
Major in Medical Parasitology
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"Estudos de biologia da multiresistência a antimaláricos em Plasmodium falciparum: transportadores ABC e genes de resposta ao stress oxidativo" (THESIS/DISSERTATION)
 muito bom
2001
Concluded
 Mestrado em Parasitologia Médica (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Muito Bom
1998
Concluded
 Parasitologia Médica (Especialização pós-licenciatura)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 16
1996
Concluded
 licenciatura em Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 14
1986
Concluded
 Dietética e Nutrição (Licenciatura)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2023/12/01 - Current Principal Investigator (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal
(...)
2007/03/01 - 2023/11/30 Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
(...)
2007/05/01 - 2007/07/31 Visiting Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidad Complutense de Madrid Facultad de Veterinaria, Spain
2001 - 2007 Research Assistant (Research) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
(...)
1989 - 2001 Research Trainee (Research) Hospital de Santa Marta, Portugal
Hospital de Santa Marta, Portugal
1997/01/01 - 1997/12/31 Visiting Researcher (Research) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Other Careers

Category
Host institution 		Employer
1989 - 1996 Assistente (Técnico Superior de Saúde - Nutrição) Hospital de Santa Marta, Portugal
1989/08 - 1989/10 Assistente (Técnico Superior de Saúde - Nutrição) Hospital CUF Tejo, Portugal
Projects

Contract

Designation Funders
2023/02/01 - Current A non-canonical protective response against malaria , Refª 2022.02426.PTDC
2022.02426.PTDC
Researcher
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

The Johns Hopkins Hospital, United States
Fundação para a Ciência e a Tecnologia
Ongoing
2019 - Current PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF
REF:46871
REF: 46871
Co-Principal Investigator (Co-PI)
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
European Union

Horizon 2020
Ongoing
2018/10/01 - Current When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity?
PTDC/BIA-CEL/28456/2017
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/06/01 - Current VIASEF - In VIvo Arthropod SEcurity Facility
FCT/P2020, FEDER. Project nº 22077
Researcher
Fundação para a Ciência e a Tecnologia
1999/01/01 - Current T-Cell response in pathogenesis of malaria infection
POCTI/36369/MGI/1999
MsC student
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto Gulbenkian de Ciência, Portugal

Institut Pasteur, France
Fundação para a Ciência e a Tecnologia
Concluded
2021/01/01 - 2025/12/31 Translação e Inovação para a Saúde Global
LA/P/0117/2020
10.54499/LA/P/0117/2020
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade Nova de Lisboa, Portugal

Universidade NOVA de Lisboa Comprehensive Health Research Centre, Portugal

Universidade de Lisboa Faculdade de Medicina Dentária, Portugal

Universidade de Coimbra, Portugal

Universidade de Évora, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/03/01 - 2023/12/31 AMAZING – AMAZonian snake toxins: creatING value from bioresources
CIRCNA/BRB/0281/2019
Researcher
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

REQUIMTE LAQV Porto, Portugal

Universidade do Porto, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidad Regional Amazónica IKIAM, Ecuador

Universidad Tecnológica Indoamérica - Quito, Ecuador

Universidade Estadual de Campinas, Brazil
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/04 - 2022/01/03 A small couple against the big three
PTDC/BTM-SAL/29786/2017
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/03/01 - 2021/02/28 Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
171129_ERA-Net_NANOpheles
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto de Salud Global Barcelona, Spain

Universiteit Twente, Netherlands

Université de Liège, Belgium
European Regional Development Fund
Concluded
2019/01/01 - 2019/12/31 Saúde Global e Medicina Tropical
UID/Multi/04413/2019
Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal

Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014/09/30 Disorders on the Glycolytic and Pentose Phosphate Pathways of the Red Blood Cell - how do they affect Plasmodium infection?
PTDC/SAU-MET/110323/2009
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS
PTDC/SAU-FAR/114864/2009
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/12/31 Proteómica y quimiogenómica de inhibidores de proteasas de origen natural con potencial terapéutico en malaria
UNESCO 230221, 2415, 230227, 230222, 239001, 320719
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidad Nacional de la Plata Facultad de Ciencias Exactas, Argentina
Ciencia y Tecnología para el Desarrollo
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 18 - 2011-2012
PEst-OE/SAU/LA0018/2011
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/30 Caracterização bioquímica e envolvimento farmacológico de metaloproteinases isoladas do parasita Trypanosoma brucei
FCT-CAPES 2011-2012
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Federal do Rio Grande do Norte Centro de Biociências, Brazil
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/04/30 Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal activity
PTDC/QUI/65142/2006
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2012 Defining the role and extent of protein glycosylation in the malaria causing parasite Plasmodium falciparum
Projectos CMDT /IHMT
Projectos CMDT /IHMT
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Centro de Investigación en Salud Internacional de Barcelona, Spain

Instituto de Salud Global Barcelona, Spain
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical
Concluded
2003/01/01 - 2006/06/30 Development of a malaria resistance DNA chip as a public health tool for the management of Plasmodium falciparum malaria drug resistance
QLK2-CT-2002-01503
PhD Student
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Schweizerisches Tropen- und Public Health-Institut, Switzerland

Institut Pasteur, France

Institut Pasteur de la Guyane, French Guiana

Institut Pasteur de Madagascar, Madagascar

Institut Pasteur du Cambodge, Cambodia

Institut Pasteur de Dakar, Senegal
European Union
Concluded
2002/04/01 - 2005/04/01 Studies on the human host pharmacogenetics and the use of antimalarials
POCTI/ESP/39580/2001
PhD Student
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/03/31 - 2005/03/31 A new approach to antimalarial therapy. Novel chemical delivery systems for primaquine and amodiaquine
POCTI/FCB/39218/2001
PhD Student
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004/08/04 - 2005/02/04 Can Malarone® be recommended as antimalarial prophylaxis for PALOP cuntries? Search for mutations in the Plasmodium falciparum cytochrome b gene associated with resistance to Malarone® in Angola, Mozambique and S. Tomé and Príncipe
FCG
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação Calouste Gulbenkian
Concluded
2002/02 - 2005/02 Studies on the genetics of drug resistance in malaria
POCTI/ESP/42666/2001
PhD Student
Fundação para a Ciência e a Tecnologia
2002/01/01 - 2004/01/01 Proteases of malaria parasites targets for chemoterapy
POCTI/ESP/42233/2001
PhD Student
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Santos, Tiago; Isabela Sales; Ana M. Ferreira; Sintra, Tânia E.; Silvana Mattedi; Simão P. Pinho; João A.P. Coutinho; Mara G. Freire; nogueira, fatima. Corresponding author: Santos, Tiago. "Artemisinin extracts with ionic liquids and salts hydrotropes as a Plasmodium falciparum antimalarial strategy". Paper presented in I Internacional Meeting Molecules 4Life, Vila Real, 2023.
    Published
  2. Elisabet Martí Coma-Cros; Christian Grandfils; Chantal Sevrin; Jos Paulusse; Naomi Hamelmann; Inga Siden-Kiamos; John Vontas; et al. "Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites". 2019.
    10.11159/nddte19.106
  3. "Plenary Lectures". 2012.
    10.1111/j.1742-4658.2010.08701.x
  4. "Abstracts from the 11th North American International Society for the Study of Xenobiotics (ISSX) Meeting. 27-31 October 2002, Orlando, Florida, USA.". 2002.
Conference poster
  1. Tiago Santos; Denise Maria Figueiredo Araujo Duarte; da Cruz Filho, Iranildo José; Maria do Carmo Alves de Lima; nogueira, fatima. Corresponding author: nogueira, fatima. "Characterization and antiplasmodial activities new Thiazole-Thiosemicarbazone derivative". Paper presented in XIV Jornadas Científicas do IHMT, 2023.
  2. Denise Maria Figueiredo Araujo Duarte; Tiago Santos; Iranildo Jose da Cruz Filho; Maria do Carmo Alves de Lima; nogueira, fatima. "Characterization and antiplasmodial activities of a new Thiazole-Thiosemicarbazone derivative". Paper presented in XIV Jornadas Científicas do IHMT, 2023.
  3. Silva, Ana Teresa; Isabel S. Oliveira; Denise Duarte; Moita, Diana; Prudêncio, Miguel; nogueira, fatima; Ferraz, Ricardo; Eduardo F. Marques; Gomes, Paula. "Antimalarial ionic liquids: synthesis, biological activity and self-aggregation properties". 2023.
  4. Santos, Tiago; Pintão, Ana; nogueira, fatima. "Antimalarial Activity of Tropaeolum majus L. Aqueous Extracts and Benzyl Isothiocyanate". Paper presented in 6th CiiEM International Congress, 2023.
  5. Santos, T.; Pintão, A. M.; nogueira, fatima. "Santos, T., Pintão, A.M , Nogueira, F. Antimalarial activity of Tropaeolum majus L. aqueous extracts and benzyl isothiocyanate . , 5-7 July 2023". 2023.
  6. Silva, Ana Teresa; Isabel S. Oliveira; Denise Duarte; Moita, Diana; Prudêncio, Miguel; nogueira, fatima; Ferraz, Ricardo; Eduardo F. Marques; Gomes, Paula. Corresponding author: Silva, Ana Teresa. "Combining natural bile acids with old basic drugs affords new triple stage antimalarial Surface-Active Ionic Liquids". 2023.
  7. Denise Maria Figueiredo Araujo Duarte; Iranildo Jose da Cruz Filho; Tiago Santos; Maria do Carmo Alves de Lima; nogueira, fatima. Corresponding author: nogueira, fatima. "Plasmodium falciparum redox system: the role of heterocycle thiosemicarbazones derivatives as potential regulators". Paper presented in XIII Jornadas Científicas do IHMT, 2022.
  8. Silva, Ana Teresa; Isabel S. Oliveira; Denise Duarte; Moita, Diana; Prudêncio, Miguel; nogueira, fatima; Teixeira, Catia; et al. Corresponding author: Silva, Ana Teresa. "Synthesis Of New Surface-Active Ionic Liquids Derived From Antimalarial Drugs And Bile Acids". 2022.
  9. Silva, Ana Teresa; Isabel S. Oliveira; Denise Duarte; Moita, Diana; Prudêncio, Miguel; nogueira, fatima; Teixeira, Catia; et al. Corresponding author: Silva, Ana Teresa. "Synthesis Of Surface-Active Ionic Liquids With Antimalarial Activity Combining Old Drugs And Bile Acids". 2022.
Journal article
  1. Celso Raul Silambo Chaves; Clemente da Silva; Acácio Salamandane; Fatima Nogueira. "Mapping Antimalarial Drug Resistance in Mozambique: A Systematic Review of Plasmodium falciparum Genetic Markers Post-ACT Implementation". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252413645.
    10.3390/ijms252413645
  2. Misael de Azevedo Teotônio Cavalcanti; Karla Joane Da Silva Menezes; Jéssika De Oliveira Viana; Éric de Oliveira Rios; Arthur Gabriel Corrêa de Farias; Karen Cacilda Weber; Fatima Nogueira; Igor José dos Santos Nascimento; Ricardo Olimpio de Moura. "Current trends to design antimalarial drugs targeting N -myristoyltransferase". Future Microbiology (2024): https://doi.org/10.1080/17460913.2024.2412397.
    10.1080/17460913.2024.2412397
  3. Inês Morais; Soraia Rodrigues; Aida Mas; Serguei Escalon; Adalzira Borrego; Fatima Nogueira; Maria Lina Antunes. "Severe Malaria in Angola: The Clinical Profile and Disease Outcome Among Adults from a Low-Endemic Area". Biomedicines (2024): https://doi.org/10.3390/biomedicines12112639.
    10.3390/biomedicines12112639
  4. Ana Teresa Silva; Isabel S. Oliveira; Inês Morais; Sofia Santana; Eyob A. Workneh; Miguel Prudêncio; f nogueira; et al. "High efficacy of chloroquine-derived bile salts in Pluronic F127 micelles against blood-stage Plasmodium falciparum". Journal of Molecular Liquids 413 (2024): https://novaresearch.unl.pt/en/publications/04e64f28-5fcf-443c-96d9-4e529a145ad3.
    10.1016/j.molliq.2024.125986
  5. Ana Figueiredo; nogueira, fatima; Katherine de Villiers; António G. Goncalves de Sousa; Lasse Votborg-Nóvel; Cäcilie von Wedel; Pinkus Tober-Lau; et al. "A Metabolite-Based Resistance Mechanism Against Malaria". Nature (2024):
    Under revision
  6. Noah Brown; Clemente da Silva; Caroline Webb; Daniela Matias; Brigite Dias; Beatriz Cancio; Miguel Silva; et al. "Antimalarial resistance risk in Mozambique detected by a novel quadruplex droplet digital PCR assay". Antimicrobial Agents and Chemotherapy (2024): e0034624-e0034624. https://novaresearch.unl.pt/en/publications/d9e09ce2-f8d1-431a-a321-26cdbf8ff8c9.
    10.1128/aac.00346-24
  7. Ana Maria Pintão; Tiago Santos; f nogueira. "Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate.". Molecules (Basel, Switzerland) 29 10 (2024): https://novaresearch.unl.pt/en/publications/59cec4d0-7f68-4877-90e8-e712e60f1f65.
    10.3390/molecules29102316
  8. Livia M. Feitosa; Rodolfo Rodrigo F. Franca; Maria de Lourdes G. Ferreira; Anna C.C. Aguiar; Guilherme E. de Souza; Sarah El Chamy Maluf; Juliana O. de Souza; et al. "Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities". European Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1016/j.ejmech.2024.116163.
    10.1016/j.ejmech.2024.116163
  9. Ana M. Ferreira; Isabela Sales; Sónia A. O. Santos; Tiago Santos; Fátima Nogueira; Silvana Mattedi; Simão P. Pinho; João A. P. Coutinho; Mara G. Freire. "Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic Liquids". Chem & Bio Engineering (2024): https://doi.org/10.1021/cbe.3c00005.
    10.1021/cbe.3c00005
  10. Ana Teresa Silva; Isabel Oliveira; Denise Maria Figueiredo Araujo Duarte; Diana Moita; Miguel Prudêncio; Fátima Nogueira; Ricardo Ferraz; Eduardo F. Marques; P. Gomes. "“Seasoning” antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits". RSC Medicinal Chemistry (2024): http://dx.doi.org/10.1039/d4md00007b.
    10.1039/d4md00007b
  11. Iranildo José da Cruz Filho; Denise Maria Figueiredo Araújo Duarte; Diego Santa Clara Marques; João Victor Ritinto da Rocha; Emily Gabriele Marques Diniz; Fábio André Brayner; Luiz Carlos Alves; et al. "Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent: an in vitro approach". 3 Biotech (2023): http://dx.doi.org/10.1007/s13205-023-03799-2.
    10.1007/s13205-023-03799-2
  12. Gustavo da Silva; André F. S. Luz; Denise Duarte; Diana Fontinha; Vera L. M. Silva; Filipe A. Almeida Paz; Ana M. Madureira; et al. "Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 Coupling and Domino Cyclization Approach". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300264.
    10.1002/cmdc.202300264
  13. CLEMENTE DA SILVA; Daniela Matias; Brigite Dias; Beatriz Cancio; Miguel Silva; Ruben Viegas; Nordino Chivale; et al. "Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins". Malaria Journal 22 1 (2023): http://dx.doi.org/10.1186/s12936-023-04589-0.
    10.1186/s12936-023-04589-0
  14. Natali de França Nibbering Santos; Natanael da Silva Bezerra Junior; Jamerson Ferreira de Oliveira; Denise Maria Figueiredo Araújo Duarte; José Cleberson dos Santos Soares; Diego Santa Clara Marques; Aline Caroline da Silva Santos; et al. "Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives". Experimental Parasitology 248 (2023): 108498-108498. http://dx.doi.org/10.1016/j.exppara.2023.108498.
    10.1016/j.exppara.2023.108498
  15. José Rafael Almeida; Ana Gomes; Bruno Mendes; Luísa Aguiar; Mariana Ferreira; Mariana Borges Costa Brioschi; Denise Duarte; et al. "Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad". International Journal of Biological Macromolecules (2023): 124745-124745. http://dx.doi.org/10.1016/j.ijbiomac.2023.124745.
    10.1016/j.ijbiomac.2023.124745
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  35. Luísa Aguiar; Arnau Biosca; Elena Lantero; Jiri Gut; Nuno Vale; Philip J. Rosenthal; Fátima Nogueira; et al. "Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates". Molecules 24 24 (2019): 4559-4559. https://doi.org/10.3390/molecules24244559.
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    Published • 10.3390/diagnostics9040168
  37. Lobo, Lis; Cabral, Lília I. L.; Sena, Maria Inês; Guerreiro, Bruno; Rodrigues, António Sebastião; de Andrade-Neto, Valter Ferreira; Cristiano, Maria L. S.; Nogueira, Fatima. "New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum". Malaria Journal 17 1 (2018): http://dx.doi.org/10.1186/s12936-018-2281-x.
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  78. Portela, C.; Afonso, C.M.M.; Pinto, M.M.M.; Lopes, D.; Nogueira, F.; do Rosário, V.. "Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoaikyl side chain". Chemistry and Biodiversity 4 7 (2007): 1508-1519. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547553741&partnerID=MN8TOARS.
    10.1002/cbdv.200790130
  79. Nogueira, F.; Gil, J.P.; Rosário, V.E.. "Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques 8 2 (2006): 85-92. https://www.sciencedirect.com/science/article/pii/S1294550106708020.
    Published • 10.1016/S1294-5501(06)70802-0
  80. Pimentel, S.; Nogueira, F.; Benchimol, C.; Quinhentos, V.; Bom, J.; Varandas, L.; Do Rosário, V.; Bernardino, L.. "Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola". Malaria Journal 5 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746322417&partnerID=MN8TOARS.
    10.1186/1475-2875-5-30
  81. "Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques (2006): https://publons.com/publon/15915951/.
    10.1016/S1294-5501(06)70802-0
  82. "Abstracts of the 7th European Congress of Chemotherapy and Infection, October 19-22, 2005, Florence, Italy.". Journal of chemotherapy (Florence, Italy) (2005):
  83. Dahlstrom, S.; Sisowath, C.; Nogueira, F.; Martensson, A.; Bjoerkman, A.; Gil, J.. "Size variations in a P. falciparu multidrug resistance protein (PfMRP) homologue and Coartem and artesunate plus amodiaquine clinical response [MIM-SD-175726]". Acta Tropica (2005): https://publons.com/publon/21941270/.
  84. "Abstracts of the 6th European Congress of Chemotherapy and Infection and the 24th Interdisciplinary Meeting of Anti-Infection Chemotherapy. 1-3 December 2004, Paris, France.". International journal of antimicrobial agents (2004):
  85. Ferreira, I.D.; Nogueira, F.; Borges, S.T.; Do Rosário, V.E.; Cravo, P.. "Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?". Molecular and Biochemical Parasitology 136 1 (2004): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342479718&partnerID=MN8TOARS.
    10.1016/j.molbiopara.2004.02.008
  86. Bagot, S.; Nogueira, F.; Collette, A.; Do Rosario, V.; Lemonier, F.; Cazenave, P.-A.; Pied, S.. "Comparative Study of Brain CD8+ T Cells Induced by Sporozoites and Those Induced by Blood-Stage Plasmodium berghei ANKA Involved in the Development of Cerebral Malaria". Infection and Immunity 72 5 (2004): 2817-2826. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142652154&partnerID=MN8TOARS.
    10.1128/IAI.72.5.2817-2826.2004
  87. Cravo, P.; Figueiredo, S.; Nogueira, F.; Lopes, D.; Ferreira, I.D.; Ferreira, C.; Gil, J.P.; Do Rosário, V.E.. "High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 98 3 (2004): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342612193&partnerID=MN8TOARS.
    10.1179/000349804225003262
  88. Gil, J.P.; Nogueira, F.; Strömberg-Nörklit, J.; Lindberg, J.; Carrolo, M.; Casimiro, C.; Lopes, D.; et al. "Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)". Molecular and Cellular Probes 17 2-3 (2003): 85-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-12444295411&partnerID=MN8TOARS.
    10.1016/S0890-8508(03)00006-9
  89. Lopes D; Rungsihirunrat K; Nogueira F; Seugorn A; Gil JP; do Rosário VE; Cravo P; et al. "Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.". Malaria Journal 1 (2002): 1-11. http://europepmc.org/abstract/med/12423551.
    10.1186/1475-2875-1-12
  90. "Abstracts of the 3rd European Congress on Tropical Medicine and International Health. September 8-11, 2002, Lisbon, Portugal.". Acta tropica (2002):
  91. Lopes, D.; Nogueira, F.; Gil, J.P.; Ferreira, C.; Do Rosário, V.E.; Cravo, P.. "pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 96 8 (2002): 831-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036976119&partnerID=MN8TOARS.
    10.1179/000349802125002284
  92. Nogueira, Fátima; Luisa Botelho, M.; Tenreiro, Rogério; Nogueira, F.; Botelho, M.L.; Tenreiro, R.. "Radioresistance studies in Methylobacterium spp.". Radiation Physics and Chemistry 52 1-6 (1998): 15-19. http://dx.doi.org/10.1016/s0969-806x(98)00024-3.
    10.1016/s0969-806x(98)00024-3
Preprint
  1. Ramos S; Ademolue TW; Jentho E; Wu Q; Guerra J; Martins R; Pires G; et al. "A HYPOMETABOLIC DEFENSE STRATEGY AGAINST PLASMODIUM INFECTION". 2021. http://europepmc.org/abstract/PPR/PPR393056.
    10.1101/2021.09.08.459402

Intellectual property

Patent
  1. Sousa, Emília; Long, Solida; Pinto, Madalena M. M.; Resende, Diana I. S. P.; Martins da Costa, Paulo; Freitas-silva, Joana; nogueira, fatima. 2020. "Sousa, M.E.L., S.; Pinto, M. M. d. M.; Resende, D. I. S. P.; Kijjoa, A.; Martins da Costa, P.; Freitas da Silva, J. M. M.; Nogueira, F. Pyrazino [1,2-b]quinazoline-3,6-diones derivatives, their production and uses thereof. International application number: PCT/IB2020/057831; International publication number: WO2021033159 A1; Filed August 20, 2020.". Portugal.
  2. nogueira, fatima. 2019. "WO 2021/033159 A1 PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF".
    Pending
  3. nogueira, fatima. 2019. "US20180186713 Antimalarial agent, methods and uses". United States.
    Granted/Issued
  4. Leão, Pedro N.; Martins, Rosário; R. Martins; Rosário Martins; Vitor Vasconcelos; Margarida Costa; Valentina Domingues; nogueira, fatima. 2019. "ANTIMALARIAL AGENT, METHODS AND USES THEREOF". United States.
    Granted/Issued

Other

Other output
  1. Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Milheiro SA; Gonçalves J; Lopes R; Madureira M; Lobo L; Lopes A; Nogueira F; et al. http://europepmc.org/abstract/PPR/PPR153029.
    10.26434/chemrxiv.12155178.v1
  2. Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria. Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierrid. 2019. Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.; et al. http://hdl.handle.net/10400.22/12978.
    10.1021/acs.jnatprod.8b01038
  3. Structure, synthesis of hierridin C and discovery of prevalent alkylresorcinol biosynthesis in picocyanobacteria. 2018. Costa, M.; Sampaio-Dias, I.E.; Castelo-Branco, R.; Scharfenstein, H.; Rezende de Castro, R.; Silva, A.; Schneider, M.P.C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095659313&partnerID=MN8TOARS.
    10.26434/chemrxiv.7090526.v1
  4. Immunological characterization of antibodies and antigens of Plasmodium falciparum in plasma samples obtained from individuals who previously stayed in malaria-endemic areas. 2015. D Portugal-Calisto; Teodósio R; f nogueira; Silva MS. https://novaresearch.unl.pt/en/publications/820558b0-aadb-41df-92b8-4c40e7a2e2fd.
  5. Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study. 2014. Patrícia Machado; Tiago R Vaz; f nogueira; João Rodrigues; Licínio Manco; Letícia Ribeiro; Ed Bergstrom; et al. https://novaresearch.unl.pt/en/publications/6ce3a4ea-127e-4b0b-9663-d686f1360621.
    10.1186/1475-2875-13-S1-P74
  6. Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique. 2011. E Lobo; Luis Coelho; B de Sousa; N Fernandes; V do Rosario; f nogueira. https://novaresearch.unl.pt/en/publications/939d6e32-aa53-4624-9ff8-98d70246eb4b.
  7. Size variations in a P. falciparu multidrug resistance protein (PfMRP) homologue and Coartem and artesunate plus amodiaquine clinical response [MIM-SD-175726]. 2005. S Dahlstrom; C Sisowath; f nogueira; A Martensson; A Bjorkman; José Pedro Gil. https://novaresearch.unl.pt/en/publications/239df65b-292c-4a89-b6b2-a7e5b9880827.
  8. Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.. 2002. Dinora Maria da Silva Lopes Lopes; Kanchana Rungsihirunrat; f nogueira; Aree Seugorn; Gil JP; Virgi´lio E. do Rosário; Pedro Cravo.
    10.60692/6kjse-65190
  9. Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.. 2002. Dinora Maria da Silva Lopes Lopes; Kanchana Rungsihirunrat; f nogueira; Aree Seugorn; Gil JP; Virgi´lio E. do Rosário; Pedro Cravo.
    10.60692/2fctt-3y104
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01/26 - Current Clinical and parasitological response at day 7 after treatment of Plasmodium falciparum malaria with ACTs and their correlation with molecular markers of drug resistance in Banga, Angola
Supervisor of Mbueno Nzila
 DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Agostinho Neto, Angola
2021/11/24 - Current Plasmodium falciparum redox system: the role of heterocycle thiosemicarbazones derivatives as potential regulators
Supervisor of Denise Maria Figueiredo Araújo Duarte
 DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Federal de Pernambuco, Brazil
2020 - Current in vitro killing rates of anti-malarial compounds
Supervisor of Tiago Santos
 Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020 - Current Custom dual-indexing and Illumina NGS to study drug resistant malaria
Co-supervisor of Brigite Dias
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10/01 - Current Antimalarial Resistance in Mozambique: Characterization of molecular markers and assessment of susceptibility to Plasmodium falciparum
Supervisor of Clemente da Silva
 Doutoramento em Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10 - Current Serum leptin and malnutrition in children with severe malaria in Mozambique
Supervisor
 Doenças Tropicais e Saúde Global (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/05 - Current Eficácia do tratamento da malária à base de artemisinina-lumefantrina e artesunato amodiaquina. Associação com os polimorfismos genéticos.
Co-supervisor of Pedro Rafael Dimbu
 CIÊNCIAS BIOMÉDICAS (PhD)
Universidade Agostinho Neto, Angola
2019 - Current Exploring bioorganometallic compounds with ferrocene moietis as antimalarials
Supervisor of Beatriz Duarte
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - Current Interruption of gametocyte to ookinete development
Supervisor of Jessica Fernandes
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/03/14 Interruption of gametocyte to ookinete development
Supervisor
 MESTRADO EM CIÊNCIAS BIOMÉDICAS (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/02/24 Ionic Liquids Applications as Antimalarial Drugs
Supervisor of Tiago Santos
MESTRADO EM PARASITOLOGIA MÉDICA /MASTER IN MEDICAL PARASITOLOGY (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/12/14 Imported malaria in Portugal: a molecular perspective of CHLO and IHMT between 2014 and 2021
Supervisor of Débora Serrano
 MESTRADO EM SAÚDE TROPICAL /MASTER IN TROPICAL HEALTH (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/09/24 Exploring bioorganometallic compounds with ferrocene moietis as antimalarials
Supervisor
 MESTRADO EM CIÊNCIAS BIOMÉDICAS (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - 2021 Identification of a potential malaria biomarker
Co-supervisor of Raquel Cardoso
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2020/05/28 Characterization of Plasmodium falciparum antigens as candidates for the development of serological tests or candidates for vaccines for malaria.
Co-supervisor of Yorleydy Ruiz Moreno
 Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/05/14 In vitro characterization of the antimalarial activity and mode of action of new PDEs and DHODH inhibitors against Plasmodium falciparum
Supervisor of Jessy Silva
 Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/01/11 Study of polymorphisms associated with P. falciparum resistance to ACTs in East Timor: Estudo da presença de polimorfismos associados à resistência de P. falciparum aos ACTs em Timor Leste
Supervisor of Patricia Duarte
Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2019 Study of antimalarial activity of new endoperoxides: potential parasite targets and mechanisms of action
Supervisor of Lis Lobo
 Doutoramento em Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/12 To be or not to be transmited, what is in the question?
Co-supervisor of Rafael Oliveira
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/01 - 2018/12 Estudo da atividade anti-malárica e anti-toxoplásmica de endoperóxidos sintéticos: alvos parasitários e mecanismo de acção Supervisor in Portugal: Fátima Nogueira (IHMT/UNL, Lisbon, Portugal) Supervisor in Brazil: Valter Ferreira de Andrade Neto (UFRJ, Natal, Brazil)
Supervisor of Lis Tavares Coelho Lobo
 Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/04 Antimalarial activity characterization of new quinazolinone derivatives
Supervisor of Vera Camões
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017 Searching for SNPs in Plasmodium falciparum drug-resistance associated genes in East Timor
Supervisor of Joana Meda
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017 New quinolones and phosphodiesterase inhibitors as antimalarials.
Supervisor of Cátia Nascimento
 Saúde Tropical (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2017 Estudo farmacodinâmico, em modelo murino-Plasmodium berghei, de compostos quimicamente definidos isolados de plantas usadas popularmente contra a malária e análise de genes de resistência aos antimaláricos em P. falciparum
Co-supervisor of Valeska Santana de Sena Pereira
Universidade Federal do Rio Grande do Norte, Brazil
2016/05/16 - 2016/07/21 Training in Methods in malaria research. Sending Institution: Istituto Tecnico Superiore ITS Biomedicale em Mirandola, Italy.
Supervisor of Federico Gilioli
 ERASMUS+ (Other)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016/04 Towards the endoperoxides mechanism of action - assessment of deleterious effects on tolerant and susceptible parasites
Supervisor of Fernanda Murtinheira
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016 Antimalarial activity mediated by efflux pumps; Actividade antimalárica mediada por bombas de efflux
Supervisor of Sílvia Pereira
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010 - 2015/07/31 Estudo da eficácia terapêutica in vivo das combinações terapêuticas baseadas nos derivados da artemisinina no tratamento de malária não complicada em Maputo
Supervisor of Elsa da Conceição Lobo
 Ciências Biomédicas (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/10 - 2015/07 Estudo de polimorfismos no gene que codifica a proteína kelch K13, um marcador de resistência às artemisininas, em Moçambique e Angola
Co-supervisor of Carlos Gil Escobar
 Saúde Tropical (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 - 2015 The antimalarials quest: Is ß- hematin a valid surrogate for native hemozoin?
Co-supervisor of Simão Nunes Paula
 Tecnologias Biomédicas (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014 Efflux pump-mediated activity of antimalarials” The student was trained in laboratorial techniques of Plasmodium falciparum in vitro culture, directed for the evaluation of antimalarial activity of candidate drugs. By the end of the training period, the trainee should be able to design, plan and execute independently laboratorial experiments aimed to characterize the parasite response to different efflux pumps inhibitors and their modulator effect on the antimalarials. Sending Institution: Jagiellonian University in Kraków, Poland
Supervisor of Karolina Chmielewska
 ERASMUS (Other)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/06 - 2013/09 Acquiring P. falciparum in-vitro culture skills for various purposes, especially in biological studies of the parasite and evaluation of the antimalarial activity in-vitro of new compounds. The student also implemented and optimized an assay based on the inhibition of the reaction GSH-haemin (fro drug screening) and tested sixteen new antimalarial candidate compounds. Sending institution: Universidad Complutense de Madrid. Madrid, Spain
Supervisor of Jaime Manzano
 ERASMUS (Other)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010/10 - 2012 Estudo da eficácia terapêutica de novos trioxolanos em estirpes sensíveis e resistentes à artemisinina e artesunato
Supervisor of Lis Coelho
 Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009 - 2011 Study of the gametocytocidal activity of primaquine derivatives; Estudo da actividade gametocitocida de derivados da primaquina
Supervisor of Elia Cabrita
 Parasitologia Médica (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/01 - Current Malaria outbreak in Cape Verde on 2017: results presentation. at Instituto Nacional de Saúde Publica de Cabo Verde, Praia, Cape Verde. (2019/01)
Meeting (Co-organisor)
2018/04 - Current Caracterização molecular de Plasmodium Falciparum em Cabo Verde (hands on workshop) Joint organization NOVA_IHMT and with Instituto Nacional de Saúde Publica de Cabo Verde at Praia, Cape Verde. (2018/04)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2024/01/29 - 2034/02/08 Organization and teaching of the Antimalarial Susceptibility Assessment workshop (54 hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola. (2024 - 2024)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Hospital Central do Lubango (HCL), Angola
2022/09/12 - 2022/09/23 Organization and teaching of the Molecular Biology Techniques workshop: molecular characterization of Plasmodium spp. (70h hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola. (2022/09/12 - 2022/09/23)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Hospital Central do Lubango (HCL), Angola
2022/05/02 - 2022/05/20 Organization and teaching of the Molecular Biology In vitro and ex vivo techniques for evaluating susceptibility to antimalarials (30 hours). Organized in collaboration with Doctors Sónia Enosse and Paulo Arnaldo from the National Institute of Health (INS), Ministry of Health of Mozambique. 2022 (2022) Instituto Nacional de Saúde de Moçambique/National Institute of Health (INS), Mozambique
2019/01/09 - 2019/01/10 organization and teaching of the "Sanger sequencing: sequence analysis" (16 hours). Organized in collaboration with Prof. Dr. Susana Campino (London School of Hygiene & Tropical Medicine, London, UK) and Master Silvania Leal from LEM, National Institute of Public Health of Cape Verde (INSP). It took place at INSP, Praia, Cape Verde. (2019)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto Nacional de Saúde Pública de Cabo Verde , Cape Verde
2018/04/16 - 2018/04/27 Organization and teaching of the Malaria Diagnosis course using molecular biology techniques. (93 hours). Organized in collaboration with Master Silvania Leal, LEM from the National Institute of Public Health of Cape Verde (INSP). It took place at INSP, Praia, Cape Verde. 16-27/04/2018. (2018 - 2018)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto Nacional de Saúde Pública de Cabo Verde , Cape Verde
2014/11/20 - 2014/11/21 Host – pathogen interaction. Towards a personalized medicine (2014/11/20 - 2014/11/21)
Round table (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01/18 - 2009/02/01 Scientific and pedagogic sessions as part of the CMDT LA PhD program in collaboration with Direcção Nacional de Saúde Pública de Angola. Organized by CMDT-LA/IHMT, Lisbon; Portugal and Direcção Nacional de Saúde Pública de Angola (Instituto Nacional de Saúde d Angola – INSA), Luanda; Angola (2009)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01/18 - 2009/02/01 Organization and teaching of the Workshop course Preparation of projects for doctoral candidacy. Organized in collaboration with Inv. Doctor Dinora Lopes (IHMT-NOVA) and Professor Doctor Filomeno Fortes (at the time of the National Directorate of Public Health of Angola). This training was carried out within the scope of the PROCAPS program, support from CMDT.LA for the doctoral program at IHMT-NOVA and the National Directorate of Public Health of Angola (started in 2006). It took place at the National Institute of Health of Angola – INSA, in Luanda (2009 - 2009) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto Nacional de Saúde de Angola (INSA), Angola
2006 - 2009 Organization of the PROCAPS program and teaching in some of the sessions. The program aimed to contribute to the training/qualification at PhD level of human resources in the health sector in Angola. 2006 – 2009. (2006 - 2009)
Workshop (Member of the Organising Committee)
 Instituto Nacional de Saúde Pública de Angola, Angola
2008/05/04 - 2008/05/11 Organization and teaching of the Malaria Diagnostic Techniques course. Within the scope of PROCAPS. Organized in collaboration with Inv. Doutora Dinora Lopes (IHMT-NOVA) and Professor Doutor Filomeno Fortes (at the time of the National Directorate of Public Health of Angola) in collaboration with the National Directorate of Public Health of Angola (Instituto Nacional de Saúde d Angola – INSA). This training was carried out within the scope of the PROCAPS program. At the National Institute of Health of Angola – INSA, in Luanda, Angola. (22h) (2008/05/04 - 2008/05/11)
Workshop
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto Nacional de Saúde de Angola – INSA, Angola
2008/01/14 - 2008/01/24 Organization and teaching of the Advances in Cellular and Molecular Biology course (320h). Organized in collaboration with Profs. Doctors Maria do Socorro Pires e Cruz and Carlos Henrique Nery Costa Federal University of Piauí, within the scope of the Collaboration between CMDT.LA of IHMT-NOVA and the Doctoral Program of the Northeast Biotechnology Network (RENORBIO), Brazil. At the Animal Health Laboratory and Institute of Tropical Diseases Natan Portella. in Teresina, Brazil. 14 - 24/01/2008. (2008/01/14 - 2008/01/24)
Workshop
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Federal do Piauí, Brazil
2006/03/01 - 2006/03/31 Organization and teaching of the course on Assessment of in vitro susceptibility of P. falciparum to anti-malarials according to WHO MARKIII. Coordination of Prof. Doctor Luís Varandas, IHMT-NOVA) in collaboration with Dr. Luís Bernardino from the Hospital Pediátrico de Luanda David Bernardino (HPL). Within the scope of the REF project: FCG contract no. 65472 (referred to in 8.1.4). At HPL in Luanda, Angola. March 2006. Angola 2002 – 2006 (2006/03/01 - 2006/03/31)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Hospital Pediátrico de Luanda David Bernardino, Angola

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016/05/10 - 2016/05/13 Tutor in the training course in the area of writing research proposals of the Special Program for Research and Training in Tropical Diseases of the World Health Organization (TDR), organized at IHMT-NOVA & TDR/WHO. 10-13/05/2016.
Workshop
 Worshop on Proposal Writing
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

World Health Organization TDR, Switzerland
2008/07/07 - 2008/07/11 Teaching of the Parasitology Workshop course. Coordination of Prof. Doctors Virgílio do Rosário (from the CMDT-LA of IHMT-NONA) and Professor Emília Noormahomed (from the Faculty of Medicine of the Eduardo Mondlane University; FM-UEM). It took place at FM-UEM, Maputo, Mozambique. (30 h) 07-11/07/2008.
Workshop
 Workshop de Parasitologia
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Faculty of Medicine of the Eduardo Mondlane University, Mozambique

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/11/11 Targeting Plasmodium falciparum protein aggregation as a new antimalarial design strategy
President of the jury
 Ines Bouzon (PhD)
Universitat de Barcelona, Spain
2020/12/04 Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale
Thesis Member
 ARNAU BIOSCA ROMANILLOS (PhD)
Universitat de Barcelona; Facultat de Farmacia i Ciències de l’Alimentació, Spain
2020/12 Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale
Thesis Member
 Arnau Biosca Romanillos (PhD)
Universitat de Barcelona Facultat de Farmacia, Spain
2019/04 TAXI – Targeting Antimalarial eX-star drugs for Intracellular delivery
(Thesis) Arguer
 Luisa Aguiar Tavares da Silva (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2016/03 Medicinal Chemistry Approaches to Malaria Drug Discovery
(Thesis) Arguer
 Sofia Alexandre Santos (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/12 Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells
(Thesis) Main arguer
 Joana Marques (PhD)
Universitat de Barcelona Facultat de Farmacia, Spain
2015/02 Malária. Que factores determinam na industria farmacêutica, a dotação orçamental para a investigação de uma vacina
(Thesis) Main arguer
 Ana Maria Pina Calado Guerra Ferreira (Master)
Universidade de Lisboa Instituto Superior de Ciências Sociais e Políticas, Portugal
2014/12 Evaluation of the involvement of efflux pumps in Schistosoma mansoni praziquantel drug resistance phenotype
(Thesis) Main arguer
 Tiago Mendes (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/11 Characterization of a new malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites
(Thesis) Main arguer
 Miguel Filipe Duarte (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11 Genotipagem da mutação G829A no gene da piruvato cinase em indivíduos da Guiné-Bissau e sua associação com a malaria
(Thesis) Main arguer
 Sara Cristina Inês Simões Pateira (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11 Gene expression during Plasmodium transmission
(Thesis) Main arguer
 Neuza Arrimar Duarte (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/12/13 Identification of drug resistance determinants in Plasmodium falciparum
(Thesis) Arguer
 João Marques (Master)
Universidade de Aveiro, Portugal
2012/03 Bioprospecting sulfated polysaccharides of seaweeds from the coast of Rio Grande do Norte: characterization of a heterofucan extracted from brown algae Sargassum filipendula that induces apoptosis in HeLa cells
(Thesis) Main arguer
 Leandro Silva Costa (PhD)
Universidade do Estado do Rio Grande do Norte, Brazil
2012/03 Evaluation of the antimalarial activity of extracts and fractions obtained from algae Gracillaria birdiae and Spatoglossum schröederi
(Thesis) Main arguer
 Gracielle Rodrigues Dantas (Master)
Universidade do Estado do Rio Grande do Norte, Brazil
2012/03 Avaliação da atividade antimalárica de extratos e frações obtidos das algas Gracillaria birdiae e Spatoglossum schröederi
(Thesis) Arguer
 Gracielle Rodrigues Dantas (Master)
Universidade Federal do Rio Grande do Norte, Brazil
2011/12 Pyruvate kinase deficiency protection against malaria: in vitro evaluation of 2,3-diphosphoglycerate toxicity and Plasmodium falciparum susceptibility
(Thesis) Main arguer
 Ana Margarida Trancoso Gomes Rosa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/11/28 Análise serológica e imunoquímica de potenciais antigénios para a pesquisa de anticorpos anti-Plasmodium falciparum em pacientes com malária importada
(Thesis) Arguer
 Rita Costa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010/07 Study of biological behavior in vitro and in vivo strains of Leishmania infantum
(Thesis) Main arguer
 Andreia Filipa Ramos Ribeiro de Lemos Albuquerque (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2023/07/01 - Current Member of the ASM (American Society for Microbiology) Subcommittee for Career Development Grant for Postdoctoral Women (CDGPW). This subcommittee aims to promote professional development opportunities for postdoctoral women, including the Career Development Grant and Training for Postdoctoral Women.
Member
 American Society for Microbiology, United States

Consulting

Activity description Institution / Organization
2022/09/23 - Current Organization and teaching of the workshop on Techniques for assessing susceptibility to anti-malarials (66 hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola. Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Hospital Central do Lubango (HCL), Angola
2018 - Current MEDICAL ENTOMOLOGY LABORATORY (LEM) scientific consultant and technical-scientific support to the LEM team since 2018. Instituto Nacional de Saúde Pública de Cabo Verde , Cape Verde
2016/06/05 - 2016/06/10 Expert evaluator - H2020 Program Evaluation of the topics: INFRAIA-01-2016-2017 & INFRAIA -02-2017 (First stage)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - Current Malaria: Plasmodium spp life cycle; drugs and resistance Global Health and Tropical Medicine (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Current UC coordinator -Thematic Rotation II Doenças Tropicais e Saúde Global (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Current UC Coordinator - Drug resistance genetics in parasitology Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current UC Coordinator - Malária Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current Malaria parasite life cycle and biology. Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current Malaria drug resistance mechanism and target Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current In vitro drug susceptibility assays (lectures and practical sessions) Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current Malaria drug resistance mechanism and targets Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current Malaria parasite life cycle and biology Parasitologia Médica (Mestrado integrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current Malaria drug resistance mechanism and targets Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current In vitro drug susceptibility assays (lectures and practical sessions) Parasitologia Médica (Mestrado integrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current Molecular Parasitology: gene expression (practical session) Parasitologia Médica (Mestrado integrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2015 Biotecnologia Aplicada às Doenças Infeciosas e Parasitárias Programa de Pós-graduação em Medicina Tropical Universidade do Estado do Amazonas, Brazil
2008 - 2015 Avanços em Biologia Celular e Molecular Biotecnologia Aplicada às Doenças Infeciosas e Parasitárias Biotecnologia/RENORBIO (Doctor of Philosophy) Universidade Federal do Piauí, Brazil
2009 - 2014 Molecular Microbiology and Parasitology GABBA - Programa Graduado em Áreas da Biologia Básica e Aplicada (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007 - 2013 Parasitologia Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2012 TEACHING ACTIVITIES AT the PhD programme, Programa de Pós-Graduação em Biotecnologia/RENORBIO at Universidade Federal do Piauí, Teresina Brazil. Teaching the following subjects: Malaria parasite life cycle and biology (lectures) Malaria drug resistance mechanism and targets (lectures) In vitro drug susceptibility assays (lectures and practical sessions Concepts and application of molecular biology in medical parasitology (Doutoramento)
2008 - 2012 Malaria parasite life cycle and biology of antimalarials drug resistance Basic and Applied Biology GABBA (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 - 2010 Parasitologia Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Journal of Antimicrobial Chemotherapy (1460-2091) Oxford University Press
2018 - Current ACS Infectious Diseases (2373-8227) American Chemical Society
2017 - Current Antimicrobial Agents and Chemotherapy (1098-6596) American Society for Microbiology
2017 - Current Nature (1476-4687) Springer Nature
2017 - Current Parasitology International (1383-5769) Elsevier
2016 - Current Experimental Parasitology (1090-2449) Elsevier
2014 - Current British Biotechnology Journal (2231-2927) Sciencedomain International
2014 - Current British Journal of Medicine and Medical Research (2231-0614) Sciencedomain International
2014 - Current Journal of Advances in Medical and Pharmaceutical Sciences (2394-1111) Sciencedomain International
2014 - Current The Lancet (1474-547X) Elsevier
2014 - Current Asian Pacific Journal of Tropical Biomedicine (2221-1691) Medknow Publications
2014 - Current plos one
2013 - Current African Journal of Pharmacy and Pharmacology (1996-0816) Academic Journals
2011 - Current Malaria Journal (1475-2875) Springer (Biomed Central Ltd.)
2008 - Current Transactions of the Royal Society of Tropical Medicine and Hygiene (1878-3503) Oxford University Press

Mentoring / Tutoring

Topic Student name
2018/09 - Current Epidemiology and health determinants: contributions to the elimination of malaria in Cape Verde Júlio Monteiro Rodrigues
2016 - Current The role of a-gal (Gala1-3Galß1-4GlcNAc-R) on Plasmodium spp. sporozoites interaction with Anopheles spp. mosquito. Helio Daniel Ribeiro Rocha
2012 - 2017/05 Development of an innovative real-time assay for antimalarial sensitivity testing and interrogation of novel compounds Maria Rebelo
2010 - 2015 Canine leishmaniosis: the role of hepatocytes and Kupffer cells during Leishmania infantum infection Maria Armanda Viana Rodrigues

Other jury / evaluation

Activity description Institution / Organization
2011/04/01 - Current Referee/expert for the decision concerning admission of a thesis PhD thesis for evaluation (Artº 4.9 b) y 4.9 c) de la Normativa de desarrollo de los artículos 21 y 22 del R.D. 1393/2007) Universidad Complutense de Madrid, Spain
Distinctions

Award

2022 Prémio Professor Doutor Cruz Ferreira
2019 Prémio Professor Doutor João Fraga e Azevedo
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2006 Premio do Anuário do Hospital Dona Estefania –Medicine.
Hospital Dona Estefânia, Portugal