MARIANA MARQUES SANTOS PINTALHÃO. Master Degree in Medicine in 2010 by the Faculty of Medicine of the University of Porto, Portugal. PhD in Cardiovascular Sciences by the Faculty of Medicine of Porto in 2024. PhD thesis entitled “New Insights into Circulating Biomarkers in Heart Failure: Unravelling the Role of Relaxin and Urocortin-2”. Completion of the "Clinical Scholars Research Training Program" (CSRT) from the Harvard Medical School - Portugal in 2013 and 2014, funded by the FCT. Internship in 2011 at Centro Hospitalar Universitário São João (CHUSJ), Porto, Portugal. Internal Medicine Residency between 2012 and 2018 at the Internal Medicine Department of CHUSJ. Hospital Assistant of Internal Medicine at CHUSJ since 2018, currently working at the Stroke Unit, Internal Medicine Department. Member of the Adult Clinical Team of the Inherited Metabolic Diseases Reference Centre of CHUSJ since 2017. Assistant Professor of Physiology of the Integrated Master in Medicine, Faculty of Medicine of the University of Porto. Member of the investigation team of the Department of Surgery and Physiology of the Faculty of Medicine of Porto. Member of the Cardiovascular Research & Development Center (UnIC) since 2009. Experience in basic, translational and clinical research, mainly in the cardiovascular field, and specifically cardiac diastolic function, heart failure and stroke. Author or co-author of more than 50 scientific communications in national and international meetings and of 19 papers in ISI Web of Science© indexed publications. Awarded with five scientific prizes.
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Personal identification

Full name
Mariana Marques Santos Pintalhão

Citation names

  • PINTALHÃO, MARIANA

Author identifiers

Ciência ID
7C12-E6AA-712F
ORCID iD
0000-0002-7863-1991

Email addresses

  • mpintalhao@med.up.pt (Professional)
  • mariana.pintalhao@chsj.min-saude.pt (Professional)

Addresses

  • Serviço de Medicina Interna, Centro Hospitalar São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - General and Internal Medicine
  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Degree Classification
2011 - 2024/10/03
Concluded
 Ciências Cardiovasculares e Respiratórias (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"New Insights into Circulating Biomarkers in Heart Failure: Unravelling the Role of Relaxin and Urocortin-2" (THESIS/DISSERTATION)
2015 - 2015
Concluded
 Curso de Pós-graduação em Antimicrobianos (Pós-Graduação)
Centro Hospitalar Universitário de São João, Portugal
 88%
2013 - 2014
Concluded
 Clinical Scholars Research Training (CSRT) I and II Certificate Program (Outros)
Harvard Medical School, United States
2011 - 2011
Concluded
 Curso de Pós-graduação de Medicina de Viagem e de Populações Móveis (Pós-Graduação)
Universidade do Porto Faculdade de Medicina, Portugal
 18
2004 - 2010
Concluded
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Efeitos miocárdicos da angiotensina 1-7 e seu papel na função contráctil após hipóxia-reoxigenação" (THESIS/DISSERTATION)
 17

Science

Category
Host institution 		Employer
2009 - Current Researcher (Research) Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2025 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2013 - Current Invited Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2013 Tutor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2018 - Current Assistente (Médica) Centro Hospitalar Universitário de São João, Portugal
2011 - 2018 Interno (Médica) Centro Hospitalar Universitário de São João, Portugal

Contract

Designation Funders
2020 - Current Unidade de Investigação e Desenvolvimento Cardiovascular
UIDB/00051/2020
Researcher
Concluded
2023/03/12 - 2024/09/11 Relaxin-2 and Pulmonary Arterial Hypertension: pathophysiological role and therapeutic potential
2022.08921.PTDC
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2018 DigitalPatient – Plataforma Tecnológica Inovadora para a Transformação de BigData em Conhecimento Digital e Apoio ao Diagnóstico Médico
NORTE-01-0246-FEDER-000007
Researcher
Concluded
2016 - 2018 Cast - Cardiac measuring Shirt for Telemedicine
E!10291
Researcher
Concluded
2015 - 2018 UNIC - Unidade de Investigação e Desenvolvimento Cardiovascular
UID/IC/00051/2013
Researcher
Concluded
2011 - 2012 Projecto Estratégico - UI 51 - 2011-2012.
PEst-C/SAU/UI0051/2011
Researcher
Concluded

Other

Designation Funders
2023 - Current OCEANIC-STROKE – “A Multicenter, International, Randomized, Placebo Controlled, Double-blind, Parallel Group and Event Driven Phase 3 Study of the Oral FXIa Inhibitor Asundexian (BAY 2433334) for the Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older After an Acute
NCT05686070
Researcher
Ongoing
2022 - Current Ensaio clínico DTX301-CL301 – “A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Human Ornithine Transcarbamylase (OTC) in Patients With Late-onset OTC Deficiency
NCT05345171
Researcher
Ongoing
2020 - Current Clinical Trial PACIFIC-STROKE -
NCT04304508
Researcher
Bayer AG, Germany
Ongoing
2019 - Current Clinical Trial SELECT - Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity
NCT03574597
Researcher
Ongoing
2013 - 2017 Clinical Trial - EDIFY (Preserved ventricular ejection fraction chronic heart failure with ivabradine study)
EUCTR2012-002742-20/CL2-16257-101
Researcher
Concluded

Publications

Book chapter
  1. PINTALHÃO, MARIANA; Von Hafe, Pedro. "Fragilidade no Idoso". In Geriatria e Gerontologia Clínica, 263-280. Porto Alegre, Brazil: Editora Universitária da PUCRS, 2020.
    Published
Conference paper
  1. PINTALHÃO, MARIANA; Maia-Rocha C; Martins clara Rafael; Adão, Rui; António barros; ADELINO LEITE-MOREIRA; Paulo Bettencourt; Paulo Castro Chaves; Brás-Silva, Carmen. "Serum Urocortin-2 is Associated With Volume Overload and Pulmonary Hypertension in Acute Heart Failure". Paper presented in AHA Scientific Sessions 2018, Chicago, 2018.
    Published
  2. PINTALHÃO, MARIANA. "Mariana Pintalhao, Carolina Maia-Rocha, Rafael Martins, Rui Adão, Antonio Barros, Adelino Leite-Moreira, Paulo Bettencourt, Paulo Castro-Chaves, and Carmen Brás-Silva. Serum Urocortin-2 is Associated With Volume Overload and Pulmonary Hypertension in Acute Heart Failure. Circulation. 2018;138:A16573". Paper presented in American Heart Association, 2018.
  3. PINTALHÃO, MARIANA. "Gonçalves F, Martins R, Mendonça L, Laundos TL, Pintalhao M, Vasques Nóvoa F, Pinho P, Amorim MJ, Nascimento DS, Leite Moreira AF, Castro-Chaves P. Acute and subacute functional effects of relaxin-2 on human mammary artery Eur J Heart Fail. 2017 May; 19 Suppl 1: 166.". Paper presented in Heart Failure Congress 2017, 2018.
  4. PINTALHÃO, MARIANA. "Gonçalves F, Martins R, Mendonça L, Laundos TL, Pintalhao M, Vasques Nóvoa F, Amorim MJ, Pinho P, Nascimento DS, Leite Moreira AF, Castro-Chaves P. Efeitos funcionais agudos e subagudos da relaxina-2 na artéria mamária humana. Rev Port Cardiol 2017;36 Supl C:82-83.". Paper presented in Congresso Portugues de Cardiologia 2017, 2017.
  5. PINTALHÃO, MARIANA. "Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gonçalves F, Mendonça L, Fontes-Carvalho R, Lourenço P, Almeida P, Leite-Moreira A, Bettencourt P. Circulating relaxin as a biomarker of pulmonary hypertension and right heart overload in acute heart failure. European Journal of Heart Failure (2016). 18 (suppl 1): 167". Paper presented in Heart Failure Congress 2016, 2016.
  6. PINTALHÃO, MARIANA. "Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gonçalves F, Mendonça L, Fontes-Carvalho R, Lourenço P, Almeida P, Leite-Moreira A, Bettencourt P. Relaxina sérica como biomarcador de hipertensão pulmonar e sobrecarga cardíaca direita na insuficiência cardíaca aguda. Rev Port Cardiol. 2016;35 Supl C: 18". Paper presented in Congresso Português de Cardiologia 2016, 2016.
  7. PINTALHÃO, MARIANA. "Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gonçalves F, Fontes-Carvalho R, Lourenço P, Leite-Moreira A, Bettencourt P. Serum relaxin as a prognostic biomarker in acute heart failure. European Heart Journal (2015) 36 (suppl 1): 1183". Paper presented in Congress of the European Society of Cardiology 2015, 2015.
  8. PINTALHÃO, MARIANA. "Lourenco P, Ribeiro A, Pintalhao M, Silva S, Bettencourt P. Neuro-humoral activation is the main prognostic determinant in acute heart failure. European Journal of Heart Failure. Abstracts Supplement (2015) 17 (Supplement 1), 289". Paper presented in Heart Failure Congress 2015, 2015.
  9. PINTALHÃO, MARIANA. "Mendonça L, Gonçalves F, Pintalhao M, Correia C, Cerqueira R, Amorim MJ, Pinho P, Leite Moreira A, Castro Chaves P. Efeitos vasculares da relaxina: avaliação do seu efeito funcional agudo e subagudo na vasorreactividade da artéria mamária. Revista Portuguesa de Cardiologia. 2015. 34 (Suppl): 13-14". Paper presented in Congresso Português de Cardiologia 2015, 2015.
  10. PINTALHÃO, MARIANA. "Mendonca L, Mendes-Ferreira P, Moreira A, Pintalhao M, Amorim MJ, Pinho P, Bras-Silva C, Leite-Moreira A, Castro-Chaves P. Angiotensin-(1-7) modulates Angiotensin II vasoconstrictor effect in human mammary artery. European Journal of Heart Failure 2014; 16(Suppl 2): 301". Paper presented in Heart Failure Congress 2014, 2014.
  11. Moreira, Pedro Chaves Meurer; Penna Leite, Ricardo; Silva, Victor Anselmo. "Cerqueira R, Mendonca L, Pintalhao M, Castro-Chaves P, Leite-Moreira A. Angiotensin 1-7 improves the contractile response to isoproterenol after hypoxia-reoxygenation: a Mas receptor and nitric oxide dependent effect. European Heart Journal (2011); 32 (Suppl 1): 962.". Paper presented in XXXIII Congress of the European Society of Cardiology, 2011.
    10.1109/wsc40007.2019.9004922
  12. PINTALHÃO, MARIANA. "Neves JS, Ferreira R, Ladeiras-Lopes R, Pintalhao M, Fontes-Carvalho R, Leite-Moreira A. Cardioprotective effects of angiotensin II receptor antagonists during acute hemodynamic overload in ischemia. European Journal of Medical Research 2010; 15 (suppl 1): 177-178". Paper presented in 21th European Students’ Conference for Medical Students and Young Doctors, 2010.
  13. PINTALHÃO, MARIANA. "Ferreira R, Neves JS, Ladeiras-Lopes R, Pintalhao M, Fontes-Carvalho R, Leite-Moreira A. Myocardial response stretch - the unexplored diastolic side of the Frank-Starling mechanism and Anrep effect and its modulation by ischemia. European Journal of Medical Research 2010; 15 (suppl 1): 24". Paper presented in 21th European Students’ Conference for Medical Students and Young Doctors, 2010.
  14. PINTALHÃO, MARIANA. "Mendonça L, Pintalhao M, Cerqueira R, Castro-Chaves P, Leite-Moreira A. Angiotensin 1-7 effects on myocardial contractility after hypoxia-reoxigenation. European Journal of Medical Research 2010; 15 (suppl 1): 188.". Paper presented in 21th European Students’ Conference for Medical Students and Young Doctors, 2010.
  15. PINTALHÃO, MARIANA. "Fontes Carvalho R, Ladeiras-Lopes R, Pintalhao M, Pires AL, Ferreira R, Castro-Chaves P, Leite-Moreira A. During acute myocardial ischemia, AT-1 receptor antagonism prevents systolic and diastolic dysfunction caused by hemodynamic overload: an effect partially mediated by AT-2 receptor activation. European Heart Journal 2010; Vol.31 (Suppl 1): 45.". Paper presented in XXXII Congress of the European Society of Cardiology, 2010.
  16. PINTALHÃO, MARIANA. "Pintalhao M, Cerqueira R, Castro-Chaves P, Leite-Moreira A. Efeitos da angiotensina 1-7 na função contráctil miocárdica após isquemia-reperfusão. Revista Portuguesa de Cardiologia 2010; 29 (supl.I): 29". Paper presented in XXXI Congresso Português de Cardiologia, 2010.
  17. PINTALHÃO, MARIANA. "Castro-Chaves P, Pintalhao M, Cerqueira R, Fontes-Carvalho R, Leite-Moreira A. Negative Inotropic Effect of Angiotensin 1–7 and Its Underlying Mechanisms. Circulation, Nov 2009; 120: S831". Paper presented in 82th Scientific Sessions of the American Heart Association, 2009.
  18. PINTALHÃO, MARIANA. "Ferreira R, Castro Ferreira R, Ladeiras-Lopes R, Ferreira-Martins J, Luísa-Pires A, Pintalhao M, Leite-Moreira A. Acute hemodynamic overload during ischemia - cardioprotective effects of ARAs.. European Journal of Medical Research 2009. Vol.14 (Suppl 2): 168". Paper presented in 20th European Students’ Conference for Medical Students and Young Doctors, 2009.
  19. PINTALHÃO, MARIANA. "Ladeiras-lopes R, Pintalhao M. Ferreira R. Leite-Moreira A. Benefits of early reperfusion and ischemic preconditioning upon the myocardial response to acute hemodynamic overload during ischemia. European Journal of Medical Research 2009. Vol.14 (Suppl 2): 93". Paper presented in 20th European Students’ Conference for Medical Students and Young Doctors., 2009.
  20. PINTALHÃO, MARIANA. "Cerqueira R, Pintalhao M, Castro-Chaves P, Fontes-Carvalho R, Leite-Moreira AF. Negative inotropic effect of angiotensin 1-7 and its modulation by the endocardial endothelium. European Journal of Medical Research 2009; Vol.14 (Suppl 2): 92". 2009.
  21. PINTALHÃO, MARIANA. "Castro-Chaves P, Pintalhao M, Fontes-Carvalho R, Cerqueira R, Leite-Moreira AF. Angiotensin 1-7 acute myocardial effects and their modulation by the endocardial endothelium. European Heart Journal 2009; Vol.30 (Abstract Supplement): 132.". Paper presented in XXXI Congress of the European Society of Cardiology, 2009.
  22. PINTALHÃO, MARIANA. "Ladeiras-Lopes R, Ferreira-Martins J, Pintalhao M, Pires AL, Ferreira R, Fontes Carvalho R, Castro-Chaves P, Leite-Moreira A. Systolic and diastolic beneficial adaptation to an acute hemodynamic overload is impaired during myocardial ischemia: benefits of early reperfusion and ischemic preconditioning. European Heart Journal 2009; Vol.30 (Suppl):570". Paper presented in XXXI Congress of the European Society of Cardiology, 2009.
  23. PINTALHÃO, MARIANA. "Ladeiras-Lopes R, Ferreira-Martins J, Pires AL, Pintalhao M, Ferreira R, Fontes-Carvalho R, Castro-Chaves P, Leite-Moreira A. Impaired adaptive response to acute hemodynamic overload during ischemia: Benefits of early reperfusion and ischemic preconditioning. European Journal of Heart Failure 2009; 8 (supl 2): ii652". Paper presented in Heart Failure Congress, 2009.
  24. PINTALHÃO, MARIANA. "Fontes-Carvalho R, Ladeiras-Lopes R, Pintalhao M, Ferreira R, Pires AL, Castro-Chaves P, Leite-Moreira A. Cardioprotective effects of ARAs upon acute hemodynamic overload during ischemia. European Journal of Heart Failure 2009; 8 (sup 2): ii147-148". Paper presented in Heart Failure Congress, 2009.
  25. PINTALHÃO, MARIANA. "Castro-Chaves P, Fontes-Carvalho R, Pintalhao M, Pimentel-Nunes P, Leite-Moreira A. O efeito da angiotensina II sobre a distensibilidade miocárdica aguda e sua modulação pelo óxido nítrico, endotelina-1 e NAD(P)H oxídase. Revista Portuguesa de Cardiologia 2009; 28 (supl.I): 143.". Paper presented in XXX Congresso Português de Cardiologia, 2009.
  26. PINTALHÃO, MARIANA. "Ladeiras-Lopes R, Ferreira-Martins J, Pintalhao M, Ferreira R, Pires AL, Fontes-Carvalho R, Castro-Chaves P, Leite-Moreira A. Resposta cardíaca à sobrecarga hemodinâmica aguda durante a isquemia e sua modulação pelo pré-condicionamento isquémico. Revis". Paper presented in XXX Congresso Português de Cardiologia, 2009.
  27. PINTALHÃO, MARIANA. "Fontes-Carvalho R, Ladeiras-Lopes R, Pintalhao M, Ferreira R, Castro-Chaves P, Leite-Moreira A. Modulação da função cardíaca pela sobrecarga hemodinâmica: um novo efeito cardioprotector dos antagonistas da angiotensina na isquemia do miocárdio. Revista Portuguesa de Cardiologia 2009; 28 (supl.I): 121". Paper presented in XXX Congresso Português de Cardiologia, 2009.
  28. PINTALHÃO, MARIANA. "Pintalhao M, Castro-Chaves P, Fontes-Carvalho R, Leite-Moreira A. Efeitos miocárdicos agudos da angiotensina 1-7 e sua modulação pelo endotélio endocárdico. Revista Portuguesa de Cardiologia 2009; 28 (supl.I): 143.". Paper presented in XXX Congresso Português de Cardiologia, 2009.
  29. PINTALHÃO, MARIANA. "Pintalhao M, Castro-Chaves P, Fontes-Carvalho R, Pimentel-Nunes P, Leite-Moreira A. Angiotensin II-induced increase in myocardial distensibility is modulated by the endocardial endothelium. European Journal of Medical Research 2008; 13 (supl 1): 130". Paper presented in 19th European Students’ Conference for Medical Students and Young Doctors, 2008.
Journal article
  1. Pintalhao, Mariana; Barros, António S.; Castro-Chaves, Paulo. "Reply to “Approaching the ideal biomarker for right heart dysfunction”". International Journal of Cardiology 419 (2025): 132676. https://doi.org/10.1016/j.ijcard.2024.132676.
    10.1016/j.ijcard.2024.132676
  2. Pintalhao, Mariana; Vasques-Nóvoa, Francisco; Barros, António S.; Lourenço, Patrícia; Couto-Viana, Benedita; Leite-Moreira, Adelino; Bettencourt, Paulo; Castro-Chaves, Paulo. "Prognostic association of circulating relaxin-2 in acute heart failure". International Journal of Cardiology 413 (2024): 132358. https://doi.org/10.1016/j.ijcard.2024.132358.
    10.1016/j.ijcard.2024.132358
  3. Pedro, Tiago; Sousa, José Maria; Fonseca, Luísa; Gama, Manuel G.; Moreira, Goreti; Pintalhão, Mariana; Chaves, Paulo C.; et al. "Exploring the use of ChatGPT in predicting anterior circulation stroke functional outcomes after mechanical thrombectomy: a pilot study". Journal of NeuroInterventional Surgery 17 3 (2024): 261-265. https://doi.org/10.1136/jnis-2024-021556.
    10.1136/jnis-2024-021556
  4. Pintalhão, Mariana; Vasques-Nóvoa, Francisco; Couto-Viana, Benedita; Pimentel, Maria João; Neves, João Sérgio; Mendonça, Luís; Saraiva, Francisca; et al. "Relaxin-2, pathophysiological insights and outcomes in heart failure with preserved ejection fraction: Findings from the NETDiamond cohort". International Journal of Cardiology 365 (2022): 87-90. http://dx.doi.org/10.1016/j.ijcard.2022.07.037.
    10.1016/j.ijcard.2022.07.037
  5. Pintalhao, Mariana; Maia-Rocha, Carolina; Castro-Chaves, Paulo; Adão, Rui; Barros, António S.; Clara Martins, Rafael; Leite-Moreira, Adelino; Bettencourt, Paulo; Bras-Silva, Carmen. "Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension". Current Problems in Cardiology 47 4 (2022): 100860. http://dx.doi.org/10.1016/j.cpcardiol.2021.100860.
    10.1016/j.cpcardiol.2021.100860
  6. Abrantes, Carla Seabra; Pintalhão, Mariana; Tavares, Sofia; Fonseca, Luísa; Chaves, Paulo Castro. "Anticoagulation after intracerebral hemorrhage in patients with atrial fibrillation: between Scylla and Charybdis". Neurological Sciences (2021): http://dx.doi.org/10.1007/s10072-021-05602-7.
    10.1007/s10072-021-05602-7
  7. Joao Matos-Ribeiro; Paulo Castro-Chaves; Marta Oliveira-Ferreira; Luísa Fonseca; Mariana Pintalhao. "Early anticoagulation in atrial fibrillation-related acute ischaemic stroke: efficacy and safety profile". Journal of Neurology (2021): https://doi.org/10.1007/s00415-021-10788-z.
    10.1007/s00415-021-10788-z
  8. Clara Gomes; Vanessa Barcelos; Verónica Guiomar; Mariana Pintalhão; Jorge Almeida; Luísa Fonseca. "Outcomes of reperfusion therapy for acute ischaemic stroke in patients aged 90 years or older: a retrospective study". Internal and Emergency Medicine (2020): https://doi.org/10.1007/s11739-020-02318-y.
    10.1007/s11739-020-02318-y
  9. Martins, Rafael Clara; Pintalhão, Mariana; Leite-Moreira, Adelino; Castro-Chaves, Paulo. "Relaxin and the Cardiovascular System: from Basic Science to Clinical Practice". Current Molecular Medicine 20 3 (2020): 167-184. http://dx.doi.org/10.2174/1566524019666191023121607.
    10.2174/1566524019666191023121607
  10. Pintalhao, Mariana; Castro-Chaves, Paulo; Bettencourt, Paulo. "Reply". European Journal of Heart Failure 19 7 (2017): 961-961. http://dx.doi.org/10.1002/ejhf.836.
    10.1002/ejhf.836
  11. Lourenço, Patrícia; Ribeiro, Ana; Pintalhão, Mariana; Cunha, Filipe M.; Pereira, Joana; Marques, Pedro; Vilaça, João Pedro; et al. "Prognostic prediction in acute heart failure patients with extreme BNP values". Biomarkers 22 8 (2017): 715-722. http://dx.doi.org/10.1080/1354750x.2017.1289243.
    10.1080/1354750x.2017.1289243
  12. Pintalhao, Mariana; Castro-Chaves, Paulo; Vasques-Novoa, Francisco; Gonçalves, Francisco; Mendonça, Luís; Fontes-Carvalho, Ricardo; Lourenço, Patrícia; et al. "Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload". European Journal of Heart Failure 19 2 (2016): 218-225. http://dx.doi.org/10.1002/ejhf.611.
    10.1002/ejhf.611
  13. Lourenço, Patrícia; Ribeiro, Ana; Cunha, Filipe M.; Pintalhão, Mariana; Marques, Pedro; Cunha, Francisco; Silva, Sérgio; Bettencourt, Paulo. "Is there a heart rate paradox in acute heart failure?". International Journal of Cardiology 203 (2016): 409-414. http://dx.doi.org/10.1016/j.ijcard.2015.10.129.
    10.1016/j.ijcard.2015.10.129
  14. Lourenço, Patrícia; Ribeiro, Ana; Pintalhão, Mariana; Silva, Sérgio; Bettencourt, Paulo. "Predictors of Six-Month Mortality in BNP-Matched Acute Heart Failure Patients". The American Journal of Cardiology 116 5 (2015): 744-748. http://dx.doi.org/10.1016/j.amjcard.2015.05.046.
    10.1016/j.amjcard.2015.05.046
  15. Dias-Neto, M.; Pintalhão, M.; Ferreira, M.; Lunet, N.. "Salt intake and risk of gastric intestinal metaplasia: Systematic review and meta-analysis". Nutrition and Cancer 62 2 (2010): 133-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749092309&partnerID=MN8TOARS.
    10.1080/01635580903305391
  16. Pintalhao, M.; Dias-Neto, M.; Peleteiro, B.; Lopes, C.; Figueiredo, C.; David, L.; Lunet, N.. "Salt intake and type of intestinal metaplasia in Helicobacter Pylori-infected Portuguese men". Nutrition and Cancer 62 8 (2010): 1153-1160. http://www.scopus.com/inward/record.url?eid=2-s2.0-78249267266&partnerID=MN8TOARS.
    10.1080/01635581.2010.513799
  17. Castro-Chaves, P.; Cerqueira, R.; Pintalhao, M.; Leite-Moreira, A.F.. "New pathways of the renin-angiotensin system: The role of ACE2 in cardiovascular pathophysiology and therapy". Expert Opinion on Therapeutic Targets 14 5 (2010): 485-496. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951101164&partnerID=MN8TOARS.
    10.1517/14728221003709784
  18. Castro-Chaves, P.; Pintalhao, M.; Fontes-Carvalho, R.; Cerqueira, R.; Leite-Moreira, A.F.. "Acute modulation of myocardial function by angiotensin 1-7". Peptides 30 9 (2009): 1714-1719. http://www.scopus.com/inward/record.url?eid=2-s2.0-67849086680&partnerID=MN8TOARS.
    10.1016/j.peptides.2009.06.008
  19. Castro-Chaves, P.; Fontes-Carvalho, R.; Pintalhao, M.; Pimentel-Nunes, P.; Leite-Moreira, A.F.. "Angiotensin II-induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart". Experimental Physiology 94 6 (2009): 665-674. http://www.scopus.com/inward/record.url?eid=2-s2.0-65649094804&partnerID=MN8TOARS.
    10.1113/expphysiol.2008.046458
Thesis / Dissertation
  1. "New Insights into Circulating Biomarkers in Heart Failure: Unravelling the Role of Relaxin and Urocortin-2". PhD, Universidade do Porto Faculdade de Medicina, 2024. https://hdl.handle.net/10216/161806.
  2. Pintalhão, Mariana Marques Santos. "Efeitos miocárdicos da angiotensina 1-7 e seu papel na função contráctil após hipóxia-reoxigenação". Master, 2011. http://hdl.handle.net/10216/53586.

Oral presentation

Presentation title Event name
Host (Event location)
2024/11/29 What’s Up in Stroke 2024 25º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna
(Portugal)
2024/11/28 The Role of Biomarkers in Heart Failure management Cardiomyopathies and Heart Failure – Pearls in knowledge and Gaps in Evidence
(Portugal)
2024/05/25 Novidades no tratamento de fase aguda do AVC isquémico – Trombólise e trombectomia 30º Congresso Nacional de Medicina Interna
Sociedade Portuguesa de Medicina Interna (Portugal)
2023/11/24 What’s Up in Stroke 22º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna
(Porto, Portugal)
2022/11/26 Guidelines no tratamento do AVC - o que há de novo. 22º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna
(Porto)
2019/11/30 Hot Topics – Causas não Ateroscleróticas de Doença de Grandes Vasos 20º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna
(Portugal)
2019/07/10 Como melhorar o uso de DOACs na prática clínica Curso de Atualização em Doença Vascular Cerebral 2019
(Portugal)
2019/04/12 Alterações cutâneas e dismorfias Red Flags em Doenças Hereditárias do Metabolismo no Adulto
Sociedade Portuguesa de Doenças Metabólicas / Centro de Referência de Doenças Hereditárias do Metabolismo do Centro Hospitalar Universitário de São João (Portugal)
2019/02 Patologia Torácica Preto no Branco – Imagiologia na Urgência
Associação de Estudantes da Faculdade de Medicina da Universidade do Porto (Portugal)
2018/11 Abordagem e Tratamento da Insuficiência Cardíaca na Prática Clínica 25 Encontro do Internato de MGF da Zona Norte
(Portugal)
2017/09/14 Diagnóstico da Insuficiência Cardíaca nos Cuidados de Saúde Primários GEM Meeting – Gaia-Espinho Medical Meeting
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - 2022 Early anticoagulation in atrial fibrillation-related acute ischemic stroke: efficacy and safety profile
Supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2022 Relaxin and HFpEF: unveiling a new contributor to personalized medicine?
Co-supervisor
 Mestrado Integrado em Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2022 Insights into Acute Ischemic Stroke Prognostic Factors in Patients with Mechanical Heart Valves
Co-supervisor
 Mestrado Integrado em Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/10/11 - Current MPS 360 – Mucopolissacaridoses e Doenças Afins (2024/10/11)
Conference
2023/10/12 - Current MPS 360 - a Caminho da Medicina Personalizada (2023/10/12 - 2023/10/12)
Congress (Member of the Organising Committee)
2021/10/08 - Current MPS 360 - Envolvimento Neurológico e Qualidade de Vida (2021/10/08 - 2021/10/08)
Congress (Member of the Organising Committee)
2021/10/07 - Current MPS 360 – Mucopolissacaridoses e Evidência do Mundo Real (2021/10/07 - 2021/10/07)
Congress (Member of the Scientific Committee)
2021/10/08 - 2021/10/08 Reunião Científica “MPS 360”, organizada pelo Centro de Referência de Doenças Hereditárias do Metabolismo do Centro Hospitalar Universitário de S. João. (2021/10/08 - 2021/10/08)
Congress (Member of the Organising Committee)
2019/07/09 - 2019/07/10 CURSO DE ATUALIZAÇÃO EM DOENÇA VASCULAR CEREBRAL 2019 (2019/07/09 - 2019/07/10)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/05/29 Thyroid Dysfunction and Heart Failure with Preserved Ejection Fraction: a Systematic Review
(Thesis) Main arguer
 Luís Pedro Rosmaninho Sousa Miranda (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/05/16 Relaxin and HFpEF: unveiling a new contributor to personalized medicine?
Supervisor
 Benedita Almeida Pires Couto Viana (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/05/19 Early anticoagulation in atrial fibrillation-related acute ischemic stroke: efficacy and safety profile.
Supervisor
 João Maria Guimarães e Matos Ribeiro Ferreira (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Conference scientific committee

Conference name Conference host
2018 - Current 13º YES Meeting (Young European Scientist Meeting)
2014 - Current 9º YES Meeting (Young European Scientist Meeting)
2023/11/24 - 2023/11/25 24º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna Porto
2023/05/04 - 2023/05/05 29º Congresso Nacional de Medicina Interna Porto
2020/11/26 - 2020/11/28 21º Congresso do Núcleo de Estudos da Doença Vascular Cerebral da Sociedade Portuguesa de Medicina Interna Porto

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/10 - 2022/02/18 Introdução ao Tratamento Acidente Vascular Cerebral Agudo Introdução ao Tratamento Acidente Vascular Cerebral Agudo (Outros) Centro Hospitalar Universitário de São João, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current SPMI Case Reports

Award

2022 Menção Honrosa 2022
2020 Menção Honrosa - "AVC e Investigação Bãsica"
Sociedade Portuguesa de Medicina Interna, Portugal
2019 AVC e Investigação Básica 2019
2018 Menção Honrosa
2015 Prémio Príncipe da Beira em Ciências Biomédicas
2010 Prémio Delta na Cardiopatia Isquémica / Sociedade Portuguesa de Cardiologia 2010
2009 1º prémio da sessão de Fisiologia e Medicina do IV Young European Scientist Meeting
2008 Prémio da Sociedade Portuguesa de Cardiologia / Prémio Delta na Cardiopatia Isquémica 2008