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Hassan Bousbaa is an Associate Professor of Cellular and Molecular Biology at the Universitary Institute of Health Sciences (IUCS) of CESPU, since 1998. PhD in Life and Health Sciences (University of Paris-Est Créteil, France, 1993). Post-doc in 1994 at Institut de Recherches Scientifiques sur le Cancer, CNRS, Villejuif, France. Post-doc fellow (1994-1998) at the lab of Molecular Genetics of Mitosis of Caúdio Sunkel at IBMC/i3S, of the University of Porto, then a lecturer of the GABBA PhD program at the same university (1998-2007). Director of the CICS research center at CESPU in 2007, and leader of the Molecular and Cellular Biology group of the same center. He was the Director of the IINFACTS (2012-2021), in charge of organizing and promoting research activities within CESPU, and Leader of the Cancer Research Group in IINFACTS. He is now a researcher and member of the Directive Board of the R&D unit UNIPRO at IUCS-CESPU. Hassan's research focused on unveiling the mechanisms of cell division (mitosis) in somatic cells in order to understand how errors in chromosome segregation arise and lead to genomic instability in cancer. He was part of the pioneering team that identified and characterized the genes involved in mitotic checkpoint signaling, such as Bub1, BubR1, Bub3, and Mad2, in Drosophila melanogaster, with great impact in the field (Journal of Cell Science 1997 110: 1979; Chromosoma 1998 107(6):376; Journal of Cell Biology 1999 146(1):13; Journal of Cell Science 2004 117(Pt 9):1757; Development 2004 132(20):4509; Molecular Biology of the Cell 2008 19(4):1798; Cell Cycle 2008 7(12):1763). His current interests include exploiting the clinical relevance of this information to identify novel cancer diagnostic and prognostic markers, as well as to develop novel therapeutic strategies to kill cancer cells or increase their sensitivity to antimitotic agents (Cancer Lett. 2018, doi: 10.1016/j.canlet.2018.10.005; Scientific Reports 2021, doi:10.1038/s41598-021-83743-7). His team collaborates with doctors to provide patient biological material. He has published >65 peer-reviewed publications cited >2000 times and has h-index 24 (Web of Science ResearcherID: K-5947-2019), and h-index 27 (Google Scholar ID: Vn1ukfsAAAAJ). He acts as a reviewer in many journals in the field and in international fellowship and grant application Evaluation Panels (AICR-UK; Wellcome Trust UK; FNRS-Belgium; Belgian Foundation against Cancer; ANR-France). He is the Editor-in-Chief and the founder of the recently launched journal "Scientific Letters - ISSN 2795-5117" and is a member of the Editorial Board for several journals in his research field. Since 2015, he is the Director of the Biomedical Sciences PhD program at IUCS-CESPU.
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Identification

Personal identification

Full name
Hassan Bousbaa

Citation names

  • Bousbaa, Hassan

Author identifiers

Ciência ID
7C15-6B99-A303
ORCID iD
0000-0002-4006-5779
Google Scholar ID
Vn1ukfsAAAAJ
Researcher Id
K-5947-2019
Scopus Author Id
6507657958

Email addresses

  • hassan.bousbaa@iucs.cespu.pt (Professional)

Telephones

Telephone
  • 224157186 (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Arab Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Beginner (A1) Advanced (C1)
Education
Degree Classification
2021/07/23
Concluded
 Training in Active Learning: Effective Practice in the Battle for Evidence: Our Duty to Adopt Active Learning (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2021/01/23
Concluded
 Training in Online Evaluation on Moodle (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/12/10
Concluded
 Training in CIÊNCIAVITAE Promoters Network (Use of the CIÊNCIAVITAE Platform) (Outros)
Fundação para a Ciência e a Tecnologia, Portugal
2020/03/13
Concluded
 Formação em Videoconferência por Zoom (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/03/04
Concluded
 Apresentação da plataforma de gestão curricular CIÊNCIAVITAE (Outros)
Fundação para a Ciência e a Tecnologia, Portugal
2019/07/26
Concluded
 Avaliação de Desempenho para Docentes (Outros)
Instituto Universitário de Ciências da Saúde, Portugal
2019/06/05
Concluded
 O Futuro da Formação na Saúde (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2019/05/04
Concluded
 Clinical Research Training Programe (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/07/02 - 2018/07/04
Concluded
 Ciência 2018, Encontro de Ciência e Tecnologia em Portugal (Science 2018, Science and Technology Meeting in Portugal) (Outros)
Fundação para a Ciência e a Tecnologia, Portugal
2018/05/05
Concluded
 Curso e Certificação em Suporte Básico da Vida e Desfibrilação Automática Externa (Course and Certification in Basic Life Support and Automated External Defibrillation) (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2016/07/16
Concluded
 Formação em EDIÇÃO MULTIMÉDIA, Lecionar com Conteúdos em Suporte Áudio e Vídeo (Training in MULTIMEDIA EDITING, Teaching with Audio and Video Content Support) (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2015/11/25
Concluded
 Bolsas de Contactos em Saúde (Outros)
Agência Nacional de Inovação SA, Portugal
2015/11/25
Concluded
 Conferencia Anual do Health Cluster Portugal (Outros)
Agência Nacional de Inovação SA, Portugal
1994 - 1998
Concluded
 Relating Mitotic Control to the Mechanisms of Cell Division (Pós-doutoramento)
Instituto de Biologia Molecular e Celular, Portugal
1993 - 1994
Concluded
 Identification of the human kinesin-related motor Eg5 (Pós-doutoramento)
Institut de Recherche Scientifique sur le Cancer, CNRS, Villejuif - France, France
1989 - 1993/07/08
Concluded
 Life and Health Sciences (Doutoramento)
Université Paris-Est Créteil Val de Marne, France
"Neurorendocrine cells of guinea pig lung: characterization and involvement in experimental allergic asthma" (THESIS/DISSERTATION)
 Très honorable avec félicitations
1988/11/15
Concluded
 Physiology and Physiopathology of the Respiratory and Circulatory Apparatuses (DEA)
Université Paris Descartes Faculté de Médecine Site Cochin, France
"Guinea pig lung neurorendocrine cells: effect of sensitization and allergic challenge" (THESIS/DISSERTATION)
 Honorable
1983 - 1987
Concluded
 Biology (Licenciatura)
Université Mohammed V de Rabat, Morocco
Affiliation

Science

Category
Host institution 		Employer
2021/09/15 - Current Researcher (Research) UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2021/12/31 - 2023/02/20 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2013/10/25 - 2021/11/15 Researcher (Research) Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2013/11/02 - 2018/01/22 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2011/03/24 - 2014/04/07 Researcher (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
1998/01/01 - 2007/12/31 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1994/09/01 - 1998/10/31 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1993/09/01 - 1994/09/01 Postdoc (Research) Institut de Recherche Scientifique sur le Cancer, CNRS, Villejuif - France, France
Institut de Recherche Scientifique sur le Cancer, CNRS, Villejuif - France, France

Teaching in Higher Education

Category
Host institution 		Employer
2003/09/01 - Current Associate Professor (University Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
1998/11/01 - 2003/09/30 Assistant Professor (University Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Positions / Appointments

Category
Host institution 		Employer
2023 - Current Topic Editor of the journal "Cancers" MDPI AG, Switzerland
2023 - Current Topic Editor of the journal "Pharmaceutics" MDPI AG, Switzerland
2023 - Current Topic Editor of the journal "Biomedicines" MDPI AG, Switzerland
2023 - Current Topic Editor of the journal "Future Pharamcology" MDPI AG, Switzerland
2023 - Current Topic Editor of the journal "Current Oncology" MDPI AG, Switzerland
2022/03 - Current Associate Editor of RevSAULS (eISSN: 2184-836X), Revista Científica Internacional da Rede Académica das Ciências da Saúde da Lusofonia (RACS) RevSALUS, Portugal
2022/01/01 - Current Director of PhD program in Biomedical Sciences Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2021/11/26 - Current Editor-in-Chief of "Scientific Letters (ISSN 2795-5117)" https://publicacoes.cespu.pt/index.php/sl/index Instituto Universitário de Ciências da Saúde, Portugal
2021/11/15 - Current Member of the Directive Board of UNIPRO UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2021/11/01 - Current Coordinator of the Research & Innovation Office Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020 - Current Editorial Board Member of "Pharmaceutics" journal MDPI AG, Switzerland
2020 - Current Editorial Board Member of "Current Forensic Science" journal Bentham Science Publishers Ltd, United Arab Emirates
2016 - Current Member of Management Board of the Instituto universitário de Ciências da Saúde Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2012 - Current Alternate Member of the Board of Directors of CESPU Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023 - 2024 Guest Editor of the journal "International Journal of Molecular Sciences" MDPI AG, Switzerland
2021/09/30 - 2022/09/30 Guest Editor of the journal Pharmaceutics (Volume II) MDPI AG, Switzerland
2014/09/01 - 2022/01/31 Director of PhD program in Biological Sciences Applied to Health Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2013/11/25 - 2021/11/15 Head of Cancer Research Group Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2013/10/25 - 2021/11/15 Director of IINFACTS (Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/09/30 - 2021/09/30 Guest Editor of journal Pharmaceutics MDPI AG, Switzerland
2006/02/10 - 2020/12/31 Member of the Ethic Commitee Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2002/02/01 - 2020/02/28 President of the Scientific Council Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2007/11/01 - 2013/10/25 Director of CICS (Centro de Investigação em Ciências da Saúde) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2003/09/01 - 2013/10/25 Head of Laboratory for Molecular and Cellular Biology (GBMC) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Others

Category
Host institution 		Employer
2022/09 - Current Guest Editor of the journal Pharmaceutics (Volume III) MDPI AG, Switzerland
2016/09 - Current Editor of IINFACTS News Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2012/01/01 - Current Contact Person - Health Custer Portugal Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2001/11/18 - Current Member of Scientific Council Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
1998 - 2007 Lecturer, PhD Program GABBA (Doctoral Program in Areas of Basic and Applied Biology) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1995/09/01 - 1998/09/01 Lecturer, PhD program, Programa Gulbenkian de Doutoramento em Medicina e Biologia Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2022 - Current PhD Fellowship | Project: Three-dimensional models of cancer to increase the predictive value of preclinical evaluation of antimitotic agents
2022.09451.BD
Supervisor
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade Federal de Minas Gerais, Brazil
Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2021 - Current PhD Fellowship | Project: The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential
BD/CBAS/CESPU/01/2021
Supervisor
UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal

Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2023/02/01 - 2027/01/31 PhD Fellowship | Project: Improving the efficacy of immunotherapy in endometrial cancer patients by combining epigenetic drugs and using patient-derived spheroid cocultures
2022.12584.BD
Supervisor
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2022/11/01 - 2026/10/31 PhD Fellowship | Project: Nature-inspired chiral flavonoids as potential antitumor agents: a mindset-shifting strategy to achieve eco-friendly drugs
2022.12419.BD
Supervisor
UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/02/01 - 2023/01/31 PhD Fellowship | Project: Improving the efficacy of immunotherapy in endometrial cancer patients by combining epigenetic drugs and using patient-derived spheroid cocultures
BD/DCB/CESPU/02/2022
Supervisor
Instituto Universitário de Ciências da Saúde, Portugal

UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2020 - 2022 PhD Fellowship | Project: Three-dimensional models of cancer to increase the predictive value of preclinical evaluation of antimitotic agents
BD/CBAS/CESPU/01/2020
Supervisor
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade Federal de Minas Gerais, Brazil
Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2016 - 2022 PhD Fellowship | Project: Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs.
SFRH/BD/116167/2016
Supervisor
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2017 PhD Fellowship | Project: PATRÍCIA MANUELA AREIAS DA SILVA
SFRH/BD/90744/2012
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Algarve, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2011 - 2016 PhD Fellowship | Project: Innovative functional polymer therapeutic nanotechnologies for siRNA delivery in lung cancer
SFRH/BD/69271/2010
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal

Northeastern University Department of Pharmaceutical Sciences, United States

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1996/01/01 - 1998 The Mitotic Checkpoint in Drosophila melanogaster
NA
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1993 - 1996 Genes required for progression through mitosis
HCM CHRX CT93 0186
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Union Network

The Human Capital and Mobility Program of the European Commission
Concluded
1989 - 1993 Neurorendocrine cells of guinea pig lung: characterization and involvement in experimental allergic asthma
NA
PhD Student Fellow
Université Paris-Est Créteil Val de Marne, France
 Gouvernement du Royaume du Maroc
Concluded

Contract

Designation Funders
2022/09/01 - 2023/08/31 The second-generation antimitotics: a second chance?
SGA4Cancer-GI2-CESPU-2022
Principal investigator
UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2022/09/01 - 2023/08/31 OVERCOMING PACLITAXEL RESISTANCE IN OVARIAN CANCER
upPTXovcar-GI2-CESPU-2022
Co-Principal Investigator (Co-PI)
UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2022/09/01 - 2023/08/31 Studies of molecular mechanisms of flavonoid derivatives with potential antitumor activity
Flav4Tumor_GI2-CESPU_2022
Researcher
UNIPRO - Unidade de Investigação em Patologia e Reabilitação Oral, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal

Centro Interdisciplinar de Investigação Marinha e Ambiental da Madeira, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2021 - 2022 Antitumor and antimicrobial activities of chiral derivatives of xanthones and flavonoids.
ActivCHIRAL_PI2RL_IINFACTS_2021
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2021 - 2022 Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents.
AntiMitoSphere_APSFCT_IINFACTS_2021
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2018/09/01 - 2022 Molecular mechanisms of chromosome segregation
POCI-01-0145-FEDER-030014
PTDC/BIA-CEL/30014/2017
Researcher
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Universidade do Algarve, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Centro de Ciências do Mar, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Chiral derivatives of xanthones and flavonoids: an integrative strategy to discovery new drug candidates
CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2019 - 2021 Biological assessment of debris from oral implants.
IMPLDEBRIS-PL-3RL-IINFACTS-2019
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2019 - 2020 Targeting the mitotic protein p31comet for cancer therapy
ComeTax-PFT-IINFACTS-2019
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2016/06/01 - 2019/06/01 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
grant.Provided by PTCRIS: 143327
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Fundação Ensino e Cultura Fernando Pessoa, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2019 Bub3 and Spindly knockout mediated by CRISPR-Cas9 technology: in vitro characterization and therapeutic potential
CRISPRTech-CESPU-2018
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2018 - 2019 Evaluation of Biologic effects of Laser Treatment of Benign and Potentially Malignant Diseases in Oral Cavity
LASERORAL-CESPU-2018
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2017 - 2018 The Mitotic Protein p31comet as a Cancer Therapeutic Target
ComeTarget_CESPU_2017
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2017 - 2018 Relating Monocarboxylate Transporters (MCTs) Expression to Macrophage Polarization in Oral Squamous Cell Carcinoma
MacrOral_CESPU_2017
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2017 - 2018 Anticancer activity of aromatic plant extracts and main terpenoids, synergy with conventional chemotherapeutics
AntiCancerAromTerpen_CESPU_2017
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2016 - 2018 INNOVMAR: Innovation and Sustainability in the Management and Exploitation of Marine Resource
NORTE-01-0145-FEDER-000035
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2015/01 - 2017/12 Interdisciplinary Centre of Marine and Environmental Research
grant.Provided by PTCRIS: 147268
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Foundation for Science and Technology
2016 - 2017 The Mitotic Protein Spindly as a Cancer Therapeutic Target.
SpindlyTarget2016
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2016 - 2017 Clinicopathological significance of Spindly and Bub3 proteins expression in oral squamous cell carcinomas.
MitOralC2016
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2014/09 - 2015/09 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents
CheckTax-CESPU-2014
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2014/09 - 2015/09 Characterisation of HER family heterodimers in oral squamous cell carcinomas using in situ proximity ligation assay
HerPLA-CESPU-2014
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2011/05 - 2015/09 Developing of new targets for cancer treatment based on siRNA contained into functionalized nanoparticles
02-GCQF-CICS-2011
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
2011/05 - 2015/09 Human Papiloma Virus (HPV) as etiologic agent of oral cancer
05-GCD-CICS-2011
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2010/06 - 2013/11 Molecular and nanotechnology-based approaches to improve the antitumor activity of small molecules
Provided by PTCRIS: 100930
100930
PTDC/SAU-FCF/100930/2008
Researcher
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2011/05 Implementation of the LAP-tagging approach in the Molecular and Cellular Biology Group
05-GBMC-CICS-2010
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2009/01 - 2010/12 Expression profile of mitotic checkpoint genes in a panel of tumor cell lines
04/GBMC/CICS/09
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2008/01 - 2008/12 Expression of Mitotic Checkpoint Proteins in Human Embryonic Stem Cell Lines: An Immunocytochemical Analysis
AL/2007/CESPU
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2004/01 - 2007/12 Genes Involved in The Mitotic Checkpoint in Drosophila melanogaster
42341
Provided by PTCRIS: 42341
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2006/11 - 2007/09 Chromosome instability associated with loss-of-function of the tumour suppressor protein Adenomatous Polyposis Coli (APC)
AL/03/2005/CESPU
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2006/04 - 2007/09 Analyzing the competence of the mitotic checkpoint in brain cancer cell lines
2F/07/2006/CESPU
2F/04/2006/CESPU
AL/08/2006/CESPU
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2005/10 - 2006/12 The mitotic checkpoint Bub3 and chromosome instability in human cells: a functional analysis
1F/08/2005/CESPU
Principal investigator
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2005/10 - 2006/12 Analysis of molecular mechanisms that coordinate microtubule-kinetochore interactions with spindle checkpoint signalling
1F/06/2005/CESPU
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
1998 - 2000 Relating Mitotic Control to the Mechanisms of Cell Division
ERBFMRXCT96000
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Union Network
1997/06/01 - 1998/10/31 O PONTO DE CONTROLE DE ASSOCIAÇÃO DO FUSO MITÓTICO QUE CONTROLA A SAÍDA DE MITOSE EM CÉLULAS EUCARIÓTICAS: CARACTERIZAÇÃO DE FOSFOEPÍTOPO 3F3/2 E CLONAGEM MOLECULAR DAS FOSFOPROTEÍNAS 3F3/2
GGP XXI/BPD/4350/96
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. Novel Anticancer Strategies. Basel, Switzerland: MDPI. 2023.
    10.3390/books978-3-0365-7030-3 • Editor
  2. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. Novel Anticancer Strategies (Volume II). Basel, Switzerland: MDPI. 2023.
    10.3390/books978-3-0365-7032-7 • Editor
Book chapter
  1. Silva, Patrícia M. A.; Silva, João P. N.; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Time-lapse Imaging to Analyze Cell Fate in Response to Antimitotics.". In Methods in Molecular Biology. New York, United States: Springer Nature, 2024.
    Accepted
  2. Maria E. Galarraga-Vinueza; Mariane Beatriz Sordi; Eduardo Antunes Bortoluzzi; João Paulo Tondela; Daniel Mongiovi; Bousbaa, Hassan; Júlio C. M. Souza. "Biocompatibilidade e testes de citocompatibilidade". In Métodos de pesquisa laboratorial em biomateriais dentários (ISBN-10 ¿ : ¿ 6558614480), 159-178. Brazil: Brazil Publishing, 2021.
    Published
  3. Rita Reis; Bousbaa, Hassan. "The Kinetochore and Mitosis: Focus on the Regulation and Correction Mechanisms of Chromosome-to-Microtubule Attachments". In Current Frontiers and Perspectives in Cell Biology. London, United Kingdom: InTechOpen, 2012.
    Published • 10.5772/33261
  4. Faria, J.; Barbosa, J.; Moura, I.M.B.; Reis, R.M.; Bousbaa, H.. "The spindle assembly checkpoint and aneuploidy". In Aneuploidy: Etiology, Disorders and Risk Factors, edited by Salvatore de Rossi and Filippo Bianchi, 59-75. New York, United States: Nova Science Publishers, 2012.
    Published
Conference abstract
  1. Flávia Barbosa; Joana Araújo; Gonçalves, Virgínia M. F.; Andreia Palmeira; Andrea Cunha; Patrícia M. A. Silva; Carla Fernandes; et al. "Evaluation of antitumor activity of xanthones conjugated with amino acids". Paper presented in III TOXRUN International Congress abstract supplement 2024 | 02-03 May, 2024, Porto, Portugal, Porto, 2024.
    Published • https://doi.org/10.48797/sl.2024.140
  2. Francisca Sampaio; Carina Gomes; João P. N. Silva; Bousbaa, Hassan; Patrícia M. A. Silva. "KSP and MPS1 kinases as potential therapeutic targets for ovarian cancer". Paper presented in III TOXRUN International Congress abstract supplement 2024 | 02-03 May, 2024, Porto, Portugal, Porto, 2024.
    Published • https://doi.org/10.48797/sl.2024.203
  3. Bárbara Pinto; Patrícia M. A. Silva; Bruno Sarmento; Juliana Carvalho-Tavares; Hassan Bousbaa. "Developing robust heterotypic 3D lung cancer cultures for drug screening: preliminary results". Paper presented in III TOXRUN International Congress abstract supplement 2024 | 02-03 May, 2024, Porto, Portugal, Porto, 2024.
    Published • https://doi.org/10.48797/sl.2024.228
  4. João P. N. Silva; Raquel Silva; Maria Do Carmo Vilas-Boas; Patrícia M. A. Silva Silva; Bousbaa, Hassan. "KSP and Aurora B as potential biomarkers and therapeutic targets for head and neck cancer". Paper presented in III TOXRUN International Congress abstract supplement 2024 | 02-03 May, 2024, Porto, Portugal, Porto, 2024.
    Published • https://doi.org/10.48797/sl.2024.204
  5. João P. N. Silva; Luís Monteiro; Patrícia M.A. Silva; Bousbaa, Hassan. "Promoting oral cancer cell death by combining an apoptosis inducer with an antimitotic". Paper presented in II UNIPRO International Congress abstract supplement 2023 | 01-02 June, 2023, Porto, Portugal, Penafiel, 2023.
    Published • https://doi.org/10.48797/sl.2023.112
  6. E. Castro; J. Moreira; P. M. A. Silva; L. Saraiva; M. Pinto; Hassan Bousbaa; H. Cidade. "Biological evaluation of new diarylpentanoid analogues for antitumor activity". Paper presented in II TOXRUN International Congress abstract supplement 2023 | 27-28 April, 2023, Porto, Portugal, Porto, 2023.
    Published • https://doi.org/10.48797/sl.2023.26
  7. B. Pinto; P. Silva; B. Sarmento; J. Carvalho-Tavares; Bousbaa, Hassan. "Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell killing in 2D and 3D culture systems". Paper presented in II TOXRUN International Congress abstract supplement 2023 | 27-28 April, 2023, Porto, Portugal, Porto, 2023.
    Published • https://doi.org/10.48797/sl.2023.24
  8. João P. N. Silva; L. Monteiro; Patrícia M.A. Silva; Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in II TOXRUN International Congress abstract supplement 2023 | 27-28 April, 2023, Porto, Portugal, Porto, 2023.
    Published • https://doi.org/10.48797/sl.2023.25
  9. Patrícia M. A. Silva; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Bousbaa, Hassan. "Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, Porto, 2022.
    Published • 10.51126/revsalus.v4iSup.267
  10. Bousbaa, Hassan. "Genetic analysis of Drosophila checkpoint genes Bub1 and Bub3.". Paper presented in Molecular Biology of the Cell, 2000.
    Published
  11. Bousbaa, Hassan. "Kinetochore phosphoepitopes identified by the 3F3/2 monoclonal antibody are expressed in Kc cells, neuroblasts and isolated chromosomes of Drosophila melanogaster.". Paper presented in EUROPEAN JOURNAL OF CELL BIOLOGY, 1997.
    Published
Conference paper
  1. Ward, Tarsha L.. "BUB3 acts differently from Bub1 and Bubr1 in the regulation of stable kinetochore-microtubule attachments.". Paper presented in 31st FEBS Meeting- Molecules in Health and Disease, Istanbul, 2006.
    Published • 10.1158/1538-7445.am2012-2056
  2. Jan Kvasnicka; Herbert J. Geschwind; Fumitaka Nakamura; Masakatsu Asada; Micheline Levame; Hassan Bousbaa; George S. Abela. "Restenosis after pulsed laser irradiation". 1993.
    Published • 10.1117/12.146578
  3. Nakamura, Fumitaka M.D.; Kvasnicka, Jan; Lu, Hanjiang; Geschwind, Herbert J.M.D.; Levame, Micheline; Bousbaa, Hassan; Lange, Francoise. "Acute effects of pulsed-laser irradiation on the arterial wall". 1992.
Conference poster
  1. Castro, Eliseba; Moreira, J. ; Silva, Patrícia M. A.; Saraiva, L.; Pinto, Madalena; Bousbaa, Hassan; Cidade, H.. Corresponding author: Bousbaa, Hassan. "Biological evaluation of new diarylpentanoid analogues for antitumor activity". Paper presented in II TOXRUN International Congress, 2023.
    https://doi.org/10.48797/sl.2023.26
  2. Pinto, Bárbara; Silva, Patrícia M. A.; Sarmento, Bruno; Carvalho-Tavares J; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell killing in 2D and 3D culture systems". Paper presented in II TOXRUN International Congress, 2023.
    https://doi.org/10.48797/sl.2023.24
  3. Silva, João P. N.; Monteiro, L.; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in II TOXRUN International Congress, 2023.
    https://doi.org/10.48797/sl.2023.25
  4. Patrícia M.A. Silva; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Bousbaa, Hassan. "INIBIÇÃO DA BUB3 + TRATAMENTO COM PACLITAXEL = UMA ESTRATÉGIA PROMISSORA PARA TRAVAR A PROLIFERAÇÃO CELULAR NO GLIOBLATOMA MULTIFORME". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2022.
  5. João P. N. Silva; Patrícia M. A. Silva; Bousbaa, Hassan. "Potenciando o efeito terapêutico do inibidor da EG5 numa combinação com Navitoclax em células de cancro oral". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2022.
  6. Bárbara F. Pinto; Novais, Pedro; Ana C. Henriques; Patrícia M. A. Silva; Juliana C. Tavares; Bousbaa, Hassan. "O Navitoclax potencializa os efeitos terapêuticos do inibidor da PLK-1 em culturas 2D e 3D de células de cancro de pulmão". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2022.
  7. Marta Pereira; Patrícia M. A. Silva; Bousbaa, Hassan. "IMPROVING THE ANTITUMORAL ACTIVITY OF SECOND-GENERATION ANTIMITOTICS.". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022.
  8. Bárbara Fernandes Pinto; Patrícia M.A. Silva; Juliana Carvalho-Tavares; Bousbaa, Hassan. "A INIBIÇÃO DA MPS-1 COMBINADA COM UM INDUTOR DA APOPTOSE POTENCIALIZA A ATIVIDADE ANTITUMORAL EM CULTURAS 2D E 3D DE CÉLULAS DE CANCRO DO PULMÃO". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022.
  9. Delgado, Leonor; Monteiro, Luís; Patrícia M. A. Silva; Bousbaa, Hassan; Fernanda Garcez; Brilhante-Simões, Paula; Prada, Justina. "BUBR1 AS A PROGNOSTIC BIOMARKER IN CANINE ORAL SQUAMOUS CELL CARCINOMA.". Paper presented in 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU)., 2022.
  10. Bousbaa, Hassan. "ANTITUMOR ACTIVITY AND FLUORESCENCE OF TETRACYCLIC THIOXANTHENES: NEW THERANOSTIC AGENTS?". Paper presented in EFMC-ISMC 2021 XXVI EFMC International Symposium on Medicinal Chemistry (Virtual Event), 2021.
  11. Bousbaa, Hassan. "INVESTIGANDO A ATIVIDADE ANTITUMORAL DO COMPOSTO PYRANOXANTONA 2 E SEU MECANISMO DE AÇÃO". Paper presented in 2.º Encontro Nacional Jovens Investigadores em Oncologia, 2020.
  12. Bousbaa, Hassan. "A combinação da inibição da p31comet com doses clinicamente relevantes de paclitaxel ou navitoclax potencia a morte de células de cancro de pulmão de não pequenas células". Paper presented in 2.º Encontro Nacional Jovens Investigadores em Oncologia, 2020.
  13. Bousbaa, Hassan. "Synthesis of enantiomeric pure chiral derivatives of 4'-methylchrysoeriol.". Paper presented in IJUP 2020 - Encontro de Investigação Jovem da Univerisdade do Porto, February 12-14, 2020, Porto, Portugal, 2020.
  14. Bousbaa, Hassan. "Xanthone derivatives as inhibitors of P-glycoprotein and of tumor cell growth: synthesis and biological evaluation.". Paper presented in 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT), January 15-17, 2020, Aveiro, Portugal, 2020.
  15. Bousbaa, Hassan. "New chalcone derivatives with suitable drug-like lipophilicity targeting mitosis.". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, November 1-30, 2019, 2019.
  16. Bousbaa, Hassan. "A inibição da molécula p31(comet) sensibiliza células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel.". Paper presented in I Encontro Nacional de Jovens Investigadores em Oncologia, 24 September, Porto, Portugal, 2019.
  17. Bousbaa, Hassan. "Targeting p31(comet) sensitizes non-small cell lung cancer cells to paclitaxel treatment.". Paper presented in GenomePT Symposium, 10 May, CIBIO-InBIO, Vairão, Vila do Conde, Portugal, 2019.
  18. Bousbaa, Hassan. "Flavonoids targeting caspases: synthesis and antitumor activity evaluation.". Paper presented in Italian-Spanish_Portuguese Joint Meeting in Medicinal Chemistry, MedChem, 17-20 July, Sicily 2018, Palermo, Italy, 2018.
  19. Bousbaa, Hassan. "Carboxyxanthone derivatives: synthesis and effect on human tumor cell lines.". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 17-19 January, 2018, Coimbra, Portugal, 2018.
  20. Bousbaa, Hassan. "New chalcone derivatives: synthesis and antitumor activity evaluation.". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 17-19 January, 2018, Coimbra, Portugal, 2018.
  21. Bousbaa, Hassan. "2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies.". Paper presented in 12th YES (Young European Scientist) Meeting, Faculty of Medicine of Porto, September 14-17, 2017, Porto, Portugal, 2017.
  22. Bousbaa, Hassan. "Synthesis, enantiomeric purity evaluation and enantioselectivity study on human tumor cell lines of new chiral derivatives of xanthones.". Paper presented in 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), August 27-31, 2017, Vienna, Austria, 2017.
  23. Bousbaa, Hassan. "Spindly Expression in Oral Squamous Cell Carcinomas.". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), May 17-20, 2017, Bengalore, India, 2017.
  24. Bousbaa, Hassan. "BubR1 as a potential biomarker of malignant transformation in oral leukoplakias.". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), May 17-20, 2017, Bengalore, India, 2017.
  25. Bousbaa, Hassan. "Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies.". Paper presented in IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto, February 08-10, 2017, Porto, Portugal, 2017.
  26. Bousbaa, Hassan. "New Prenylated Chalcone Acting as an Antimitotic Agent and Inducing Mitotic Catastrophe in Human Breast Adenocarcinoma MCF-7 Cell Line.". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 28-29 April, 2016, Porto, Portugal, 2016.
  27. Bousbaa, Hassan. "Targeting Spindly as Antimitotic Strategy to Induce Cancer Cell Death.". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 28-29 April, 2016, Porto, Portugal, 2016.
  28. Bousbaa, Hassan. "Pharmacokinetics and Biodistribution of epidermal growth factor receptor-targeted chitosan nanoparticles containing Mad2 siRNA in a non-small cell lung cancer model. Personalized therapy: new advances in drug design, bioassay and PK/PD modelling.". Paper presented in Le GMP : Groupe de Pharmacocinétique et Métabolisme, Ocober 21-23, Paris, France, 2015.
  29. Bousbaa, Hassan. "Acetylated flavonoids and xanthones: synthesis and screening for antitumor activity.". Paper presented in III Encontro Nacional de Estudantes de Química, March 27-29, 2015, Aveiro, Portugal, 2015.
  30. Bousbaa, Hassan. "A new prenylated chalcone with anti-mitotic activity in cancer cell lines.". Paper presented in XX Encontro Luso-Galego de Química, November 26-29, 2014, Porto, Portugal, 2014.
  31. Bousbaa, Hassan. "Assessing the anti-mitotic activity of a new prenylated chalcone in cancer cell lines.". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, November 6-7, 2014, Porto, Portugal, 2014.
  32. Bousbaa, Hassan. "Evaluating the prognostic value of BubR1 and Mad2 mitotic checkpoint protein expression in oral squamous cell carcinoma.". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, November 6-7, 2014, Porto, Portugal, 2014.
  33. Bousbaa, Hassan. "2’,4’-Dihydroxy-3,4,5-trimethoxychalcone acts as anti-mitotic agent and induces mitotic catastrophe in MCF-7 breast cancer cells.". Paper presented in EFMC-ISMC 2014, XXIII International Symposium on Medicinal Chemistry, September 7-11, 2014, Lisbon, Portugal, 2014.
  34. Bousbaa, Hassan. "Functional relationship between the mitotic checkpoint protein Bub3 and the molecular motor dynein in regulating kinetochore-micrtubule attachment.". Paper presented in EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function, 28-31 May, 2014, EMBL Advanced Training Centre, Heidelberg, Germany, 2014.
  35. Bousbaa, Hassan. "Development of EGFR-Targeted Chitosan Nanoparticles for Delivery of Mad2 Gene Silencing siRNA In Resistant Lung Cancer.". Paper presented in Northeastern University - Pharm Sci Research Showcase, May 16, 2014, Boston, Massachusetts, USA, 2014.
  36. Bousbaa, Hassan. "EGFR-Targeted Chitosan Nanoparticles for Combination Mad2 Gene Silencing and Cisplatin Therapy in Resistant Lung Cancer.". Paper presented in Annual Principal Investigators Meeting of the NCI Alliance for Nanotechnology in Cancer, September 17-19, 2013, Bethesda, Maryland, USA, 2013.
  37. Bousbaa, Hassan. "A potent small molecule that irreversible induces cell death in MCF-7 breast cancer cells.". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, April 11-12, 2013, IPATIMUP, Porto Portugal., 2013.
  38. Bousbaa, Hassan. "Exploring the anti-mitotic activity of a new small molecule in MCF-7 breast cancer cells.". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, April 11-12, 2013, IPATIMUP, Porto Portugal, 2013.
  39. Bousbaa, Hassan. "High CDC20 expression is associated with poor prognosis in oral squamous cell carcinoma.". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, April 11-12, 2013, IPATIMUP, Porto Portugal, 2013.
  40. Bousbaa, Hassan. "Search of enantioselectivity on the inhibitory effect of chiral derivatives of xanthones on growth of human tumor cell lines.". Paper presented in 3º Encontro Nacional de Química Terapêutica, November 28-30, 2012, Aveiro, Portugal, 2012.
  41. Bousbaa, Hassan. "A new small molecule with anti-mitotic activity in MCF-7 breast cancer cells.". Paper presented in 3º Encontro Nacional de Química Terapêutica, November 28-30, 2012, Aveiro, Portugal, 2012.
  42. Bousbaa, Hassan. "Chitosan-cetuximab conjugate for pulmonary siRNA delivery.". Paper presented in 9th International Symposium on Polymer Therapeutics: Laboratory to Clinical Practice, May 28-30, 2012, Valencia, Spain, 2012.
  43. Faria, Juliana; Joana Barbosa; Bousbaa, Hassan; Pedro Moradas-Ferreira; Queiros, Odilia; Roxana Falcão-Moreira. "Non-classical targeting and regulation of the expression of GAPDH1p from K. marxianus". Paper presented in XVII Congresso Nacional de Bioquímica, 15 – 17 December 2010, Porto, Portugal., 2010.
  44. Joana Barbosa; Juliana Faria; Tiago Silva; Hassan Bousbaa; Odília Queirós; Pedro Moradas-Ferreira; Francisco Ferreira-da-Silva; Roxana Falcão-Moreira. "Non-classical targeting and regulation of expression of GAPDH1 from Kluyveromyces marxianus.". Paper presented in Microbiotec´19, Congress of Microbiology and Biotechnology. December 5-7 (Coimbra, Portugal)., 2009.
  45. Bousbaa, Hassan. "Molecular alterations underlying the mitotic checkpoint defects in glioblastoma cell lines.". Paper presented in III Jornadas das Ciências do ISCS-N, April 17-18, 2009, Centro de Congressos Alfândega do Porto, Portugal, 2009.
  46. Bousbaa, Hassan. "Altered expression of the mitotic checkpoint genes in an oral squamous cell carcinoma cell line.". Paper presented in III Jornadas das Ciências do ISCS-N, April 17-18, 2009, Centro de Congressos Alfândega do Porto, Portugal, 2009.
  47. Bousbaa, Hassan. "Perfil de expressão de proteínas do checkpoint mitótico ao longo do ciclo celular.". Paper presented in III Jornadas das Ciências do ISCS-N, April 17-18, 2009, Centro de Congressos Alfândega do Porto, Portugal, 2009.
  48. Bousbaa, Hassan. "Interferindo com a expressão dos genes do checkpoint mitotic em linhas tumorais com estatutos de checkpoint mitótico diferentes.". Paper presented in III Jornadas das Ciências do ISCS-N, April 17-18, 2009, Centro de Congressos Alfândega do Porto, Portugal, 2009.
  49. Silva T; Santos D; Monteiro I; Blanquett R; Barbosa MJ; Faria JF; Bousbaa H; et al. "Endereçamento não clássico e regulação da expressão da GAPDH1p (p37) de Kluyveromyces marxianus - estratégias de estudo.". Paper presented in III Jornadas de Ciências do ISCSN. Porto, Portugal., 2009.
  50. Bousbaa, Hassan. "Study of the mitotic checkpoint competence in a medulloblastoma cell line.". Paper presented in II Jornadas das Ciências do ISCS-N, April 18-19, 2008, Centro de Congressos Alfândega do Porto, Portugal., 2008.
  51. Odília Queirós; Hassan Bousbaa; Elsa Cardoso; Roxana Falcão-Moreira. "Tutorial project in the Biochemistry degree of ISCS-N: A valuable approach in biochemical education.". Paper presented in XVI Congresso Nacional de Bioquímica. Açores, Portugal., 2008.
  52. Bousbaa, Hassan. "A role for human checkpoint protein Bub3 in the regulation of kinetochore-microtubule attachments.". Paper presented in 31st FEBS Meeting- Molecules in Health and Disease, Istanbul, Turkey, 2006.
  53. Bousbaa, Hassan. "Lagged without Bub3: a new role for the spindle checkpoint protein Bub3 at the kinetochore-microtubule interface.". Paper presented in 45th Anual Meeting of the American Society for Cell Biology, San Francisco, USA, 2005.
  54. Bousbaa, Hassan. "Multiple roles for the Drosophila BubR1 kinase during mitotic progression.". Paper presented in XIV National Congress of Biochemistry, Vilamoura, Portugal, 2004.
  55. Bousbaa, Hassan. "Mad2 is an essential spindle checkpoint protein in Drosophila.". Paper presented in XIV National Congress of Biochemistry, Vilamoura, Portugal, 2004.
  56. Bousbaa, Hassan. "Microtubule-attachment and tension at kinetochores are distinctly monitored by spindle checkpoint proteins in Drosophila cells.". Paper presented in 43rd Annual Meeting of The American Society of Cell Biology, San Francisco, California, USA, 2003.
  57. Bousbaa, Hassan. "Early kinetochore localisation of Drosophila BubR1 and Bub1 requires Bub3, whose function is also important for the regulation of APC activity throughout cell cycle.". Paper presented in Jacques Monod Conference-CNRS on "The Cell Cycle and its checkpoints", Roscoff, France., 2002.
  58. Bousbaa, Hassan. "Kinetochore localisation of the spindle checkpoint proteins BubR1 and Bub3 is regulated by tension-sensitive kinetochore phosphorylation.". Paper presented in Jacques Monod Conference-CNRS on "The Cell Cycle and its checkpoints", September 21-25, 2002, Roscoff, France., 2002.
  59. Bousbaa, Hassan. "The role of Bub1 and Bub3 in regulating mitotic progression.". Paper presented in 5th International Workshop on Chromosome Segregation and Aneuploidy, Chartres, France, 2001.
  60. Bousbaa, Hassan. "Phenotype characteriztion of a PP1 phosphatase Drosophila melanogaster mutant.". Paper presented in 4 th International Workshop on Chromosome Segregation and Aneuploidy, Porto, Portugal, 1998.
  61. Bousbaa, Hassan. "Kinetochore phosphoepitopes involved in cell cycle checkpoints are expressed in Kc cells, neuroblasts and isolated chromosomes of D. melanogaster.". Paper presented in 11th European Cell Cycle Conference, Gardone Riviera, Italy., 1997.
  62. Bousbaa, Hassan. "Isolation of mitotic chromosomes from Drosophila melanogaster Kc cells.". Paper presented in X National Congress of Biochemistry, Braga, Portugal, 1996.
  63. Bousbaa, Hassan. "Isolation of a synaptotagmin isoform in drosophila melanogaster.". Paper presented in X National Congress of Biochemistry, Braga, Portugal, 1996.
Encyclopedia entry
  1. João P. N. Silva; Bárbara F. Pinto; Luís Monteiro; Patrícia M. A. Silva; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Combination Therapy to Fight Oral Cancer". In Scholarly Community Encyclopedia. MDPI, 2023. https://encyclopedia.pub/entry/45284.
    Published
  2. Bousbaa, Hassan; Patrícia M. A. Silva. "The Role of BUB3 in Human Cancers". In Scholarly Community Encyclopedia. MDPI, 2022. https://encyclopedia.pub/entry/23283.
    Published
  3. Bousbaa, Hassan. "BP-M345 as a New Diarylpentanoid". In Scholarly Community Encyclopedia, 2021. https://encyclopedia.pub/17859.
    Published
  4. Bousbaa, Hassan. "Three-Dimensional Spheroids in Cancer Research". In Encyclopedia. MDPI, 2020. https://encyclopedia.pub/4218.
  5. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Antimitotic Drugs". In Schwab, M. (eds) Encyclopedia of Cancer. Springer, 2014. https://doi.org/10.1007/978-3-642-27841-9_7074-1.
    10.1007/978-3-642-27841-9_7074-1
Journal article
  1. Almeida-Nunes, Diana Luísa; Silva, João P. N.; Nunes, Mariana; Silva, Patrícia M. A.; Silvestre, Ricardo; Dinis-Oliveira, Ricardo Jorge; Bousbaa, Hassan; Ricardo, Sara. "Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines". International Journal of Molecular Sciences 25 22 (2024): 11935. http://dx.doi.org/10.3390/ijms252211935.
    Open access • Published • 10.3390/ijms252211935
  2. Calheiros-Lobo, Mafalda; Silva, João P. N.; Delgado, Leonor; Pinto, Bárbara; Monteiro, Luís; Lopes, Carlos; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer: A Plausible Alliance to Enhance Cell Death". Cancers 16 22 (2024): 3732. http://dx.doi.org/10.3390/cancers16223732.
    10.3390/cancers16223732
  3. Silva, Helena Gomes; Sobral, Rómulo; Alhinho, Ana Teresa; Afonso, Hugo Ricardo; Ribeiro, Teresa; Silva, Patrícia M. A.; Bousbaa, Hassan; Morais-Cecílio, Leonor; Costa, Maria Manuela Ribeiro. "Genetic and epigenetic control of dormancy transitions throughout the year in the monoecious cork oak". Physiologia Plantarum 176 6 (2024): http://dx.doi.org/10.1111/ppl.14620.
    Open access • Published • 10.1111/ppl.14620
  4. Calheiros-Lobo, Mafalda; Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer". Pharmaceutics 16 9 (2024): 1196. http://dx.doi.org/10.3390/pharmaceutics16091196.
    Open access • Published • 10.3390/pharmaceutics16091196
  5. Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing". Cancers 16 11 (2024): 2014. http://dx.doi.org/10.3390/cancers16112014.
    Open access • Published • 10.3390/cancers16112014
  6. Henriques, Ana C.; Silva, João; Pinto, Bárbara; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous Cell Carcinoma Cells". Scientific Letters 1 1 (2024): 5. https://doi.org/10.48797/sl.2024.121.
    Open access • Published
  7. Barbosa, Flávia; Araújo, Joana; Gonçalves, Virgínia M. F.; Palmeira, Andreia; Cunha, Andrea; Silva, Patrícia M. A.; Fernandes, Carla; et al. "Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids". International Journal of Molecular Sciences 25 4 (2024): 2121. http://dx.doi.org/10.3390/ijms25042121.
    10.3390/ijms25042121
  8. Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Matias de Souza, Júlio César; Tiritan, Maria Elizabeth; Vieira, Nuno Brito; et al. Corresponding author: Bousbaa, Hassan. "The Brightness of Multidisciplinary Approaches in Health Sciences Research". Scientific Letters 1 1 (2024): https://doi.org/10.48797/sl.2024.120.
    Open access • Published
  9. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Editorial Acknowledgment to Reviewers of Scientific Letters in 2023". Scientific Letters 1 1 (2024): https://doi.org/10.48797/sl.2024.118.
    Published
  10. Moreira, Joana; Silva, Patrícia M. A.; Castro, Eliseba; Saraiva, Lucília; Pinto, Madalena; Bousbaa, Hassan; Cidade, Honorina. Corresponding author: Bousbaa, Hassan. "BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity". International Journal of Molecular Sciences 25 3 (2024): 1691. http://dx.doi.org/10.3390/ijms25031691.
    Open access • Published • 10.3390/ijms25031691
  11. Pinto, Bárbara; Silva, João P. N.; Silva, Patrícia M. A.; Barbosa, Daniel José; Sarmento, Bruno; Tavares, Juliana Carvalho; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics 16 1 (2023): 56. http://dx.doi.org/10.3390/pharmaceutics16010056.
    Open access • Published • 10.3390/pharmaceutics16010056
  12. Moreira, Joana; Silva, Patrícia M. A.; Barros, Matilde; Saraiva, Lucília; Pinto, Madalena; Bousbaa, Hassan; Cidade, Honorina. Corresponding author: Bousbaa, Hassan. "Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure-Activity Relationship Studies". Pharmaceuticals 16 6 (2023): 879. http://dx.doi.org/10.3390/ph16060879.
    Open access • Published • 10.3390/ph16060879
  13. Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Combination Therapy as a Promising Way to Fight Oral Cancer". Pharmaceutics 15 6 (2023): 1653. http://dx.doi.org/10.3390/pharmaceutics15061653.
    Open access • 10.3390/pharmaceutics15061653
  14. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Novel Anticancer Strategies II". Pharmaceutics 15 2 (2023): 605. http://dx.doi.org/10.3390/pharmaceutics15020605.
    Open access • Published • 10.3390/pharmaceutics15020605 • Editor
  15. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Editorial to the first issue of Scientific Letters". Scientific Letters 1 1 (2023): 2. https://doi.org/10.48797/sl.2023.19.
    Open access • Published • 10.48797/sl.2023.19 • Editor
  16. Editorial Board. Corresponding author: Editorial Board. "Editorial Acknowledgment to Reviewers of Scientific Letters in 2022". Scientific Letters 1 1 (2023): 1. https://doi.org/10.48797/sl.2023.18.
    Open access • Published • 10.48797/sl.2023.18 • Editor
  17. Delgado, Leonor; Monteiro, Luís; Silva, Patrícia; Bousbaa, Hassan; Garcez, Fernanda; Silva, João; Brilhante-Simões, Paula; Pires, Isabel; Prada, Justina. "BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma". Animals 12 22 (2022): 3082. http://dx.doi.org/10.3390/ani12223082.
    10.3390/ani12223082
  18. Pinto, Bárbara; Novais, Pedro; Henriques, Ana C.; Carvalho-Tavares, Juliana; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems". Pharmaceutics 14 6 (2022): 1209. http://dx.doi.org/10.3390/pharmaceutics14061209.
    Open access • Published • 10.3390/pharmaceutics14061209
  19. Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "BUB3, beyond the Simple Role of Partner". Pharmaceutics 14 5 (2022): 1084. http://dx.doi.org/10.3390/pharmaceutics14051084.
    Open access • Published • 10.3390/pharmaceutics14051084
  20. Bárbara Fernandes Pinto; Catarina Pacheco; Patrícia M. A. Silva; Juliana Carvalho-Tavares; Bruno Sarmento; Hassan Bousbaa. Corresponding author: Hassan Bousbaa. "Nanomedicine internalization and penetration: why should we use spheroids?". Scientific Letters 1 1 (2022): 3. https://doi.org/10.48797/sl.2022.12.
    Open access • Published • 10.48797/sl.2022.12
  21. Patrícia M.A. Silva; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Hassan Bousbaa. Corresponding author: Hassan Bousbaa. "Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence". Scientific Letters 1 1 (2022): 1. https://doi.org/10.48797/sl.2022.11.
    Open access • Published • 10.48797/sl.2022.11
  22. Novais, Pedro; Silva, Patrícia M. A.; Moreira, Joana; Palmeira, Andreia; Amorim, Isabel; Pinto, Madalena; Cidade, Honorina; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity". Molecules 26 23 (2021): 7139. http://dx.doi.org/10.3390/molecules26237139.
    Open access • 10.3390/molecules26237139
  23. Monteiro, L.; Silva, P.; Delgado, L.; Amaral, B.; Garcês, F.; Salazar, F.; Pacheco, JJ.; et al. "Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study". Medicina Oral Patología Oral y Cirugia Bucal (2021): e719-e728. http://dx.doi.org/10.4317/medoral.24511.
    Published • 10.4317/medoral.24511
  24. Nunes, Mariana; Silva, Patrícia M. A.; Coelho, Ricardo; Pinto, Carla; Resende, Albina; Bousbaa, Hassan; Almeida, Gabriela M.; Ricardo, Sara. "Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.752127.
    10.3389/fonc.2021.752127
  25. Novais, Pedro; Silva, Patrícia M. A.; Amorim, Isabel; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Second-Generation Antimitotics in Cancer Clinical Trials". Pharmaceutics 13 7 (2021): 1011. http://dx.doi.org/10.3390/pharmaceutics13071011.
    Published • 10.3390/pharmaceutics13071011
  26. Durães, Fernando; Silva, Patrícia M. A.; Novais, Pedro; Amorim, Isabel; Gales, Luís; Esteves, Cátia I. C.; Guieu, Samuel; et al. Corresponding author: Bousbaa, Hassan. "Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity". Molecules 26 11 (2021): 3315. http://dx.doi.org/10.3390/molecules26113315.
    Published • 10.3390/molecules26113315
  27. Messous, Redouane; Henriques, Bruno; Bousbaa, Hassan; Silva, Filipe S.; Teughels, Wim; Souza, Júlio C. M.. "Cytotoxic effects of submicron- and nano-scale titanium debris released from dental implants: an integrative review". Clinical Oral Investigations (2021): http://dx.doi.org/10.1007/s00784-021-03785-z.
    10.1007/s00784-021-03785-z
  28. Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Novel Anticancer Strategies". Pharmaceutics 13 2 (2021): 275. http://dx.doi.org/10.3390/pharmaceutics13020275.
    10.3390/pharmaceutics13020275 • Editor
  29. Henriques, Ana C.; Silva, Patrícia M. A.; Sarmento, Bruno; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-83743-7.
    10.1038/s41598-021-83743-7
  30. Henriques, Ana C.; Silva, Patrícia M. A.; Sarmento, Bruno; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "The Mad2-Binding Protein p31comet as a potential target for human cancer therapy". Current Cancer Drug Targets 21 (2021): http://dx.doi.org/10.2174/1568009621666210129095726.
    10.2174/1568009621666210129095726
  31. Phyo, Ye' Zaw; Teixeira, Joana; Gonçalves, Ricardo; Palmeira, Andreia; Tiritan, Maria Elizabeth; Bousbaa, Hassan; Pinto, Madalena M.M.; Fernandes, Carla; Kijjoa, Anake. "Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies". Chirality (2021): http://dx.doi.org/10.1002/chir.23297.
    10.1002/chir.23297
  32. França, Fábio; Silva, Patrícia M. A.; Soares, José X.; Henriques, Ana C.; Loureiro, Daniela R. P.; Azevedo, Carlos M. G.; Afonso, Carlos M. M.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel". Molecules 25 24 (2020): 5845. http://dx.doi.org/10.3390/molecules25245845.
    10.3390/molecules25245845
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    10.1002/slct.202002588
  35. Loureiro, Daniela R. P.; Magalhães, Álvaro F.; Soares, José X.; Pinto, Joana; Azevedo, Carlos M. G.; Vieira, Sara; Henriques, Ana; et al. "Yicathins B and C and analogues: total synthesis, lipophilicity and biological activities". ChemMedChem (2020): http://dx.doi.org/10.1002/cmdc.201900735.
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  36. Moreira, Joana; Ribeiro, Diana; Silva, Patrícia; Nazareth, Nair; Monteiro, Madalena; Palmeira, Andreia; Saraiva, Lucília; et al. Corresponding author: Bousbaa, Hassan. "New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation". Molecules 24 1 (2019): 129. http://dx.doi.org/10.3390/molecules24010129.
    10.3390/molecules24010129
  37. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. Corresponding author: Bousbaa, Hassan. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    10.1016/j.ejmech.2019.111752
  38. Matias de Souza, Júlio César; Carvalho, Oscar; Henriques, Bruno; Silva, Filipe; Bousbaa, Hassan; Caramês, João. "Biomateriais sintéticos e xenógenos com alto potencial clínico para reparo tecidual". RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia 1 2 (2019): 17-23. http://dx.doi.org/10.51126/revsalus.v1i2.115.
    10.51126/revsalus.v1i2.115
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  40. Ana C. Henriques; Diana Ribeiro; Joel Pedrosa; Bruno Sarmento; Patrícia M.A. Silva; Hassan Bousbaa. Corresponding author: Hassan Bousbaa. "Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution". Cancer Letters 440-441 (2019): 64-81. https://doi.org/10.1016/j.canlet.2018.10.005.
    10.1016/j.canlet.2018.10.005
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    10.3390/molecules23051093
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    10.1111/j.1365-2184.2011.00767.x
  63. Barbosa, J.; Nascimento, A.V.; Faria, J.; Silva, P.; Bousbaa, H.. Corresponding author: Bousbaa, H.. "The spindle assembly checkpoint: Perspectives in tumorigenesis and cancer therapy". Frontiers in Biology 6 2 (2011): 147-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051713496&partnerID=MN8TOARS.
    10.1007/s11515-011-1122-x
  64. Pinho, T.; Silva-Fernandes, A.; Bousbaa, H.; MacIel, P.. "Mutational analysis of MSX1 and PAX9 genes in Portuguese families with maxillary lateral incisor agenesis". European Journal of Orthodontics 32 5 (2010): 582-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957771535&partnerID=MN8TOARS.
    10.1093/ejo/cjp155
  65. Logarinho, Elsa; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Kinetochore-microtubule interactions “in check” by Bub1, Bub3 and BubR1: The dual task of attaching and signalling". Cell Cycle 7 12 (2008): 1763-1768. http://dx.doi.org/10.4161/cc.7.12.6180.
    Published • 10.4161/cc.7.12.6180
  66. Logarinho, E.; Resende, T.; Torres, C.; Bousbaa, H.. Corresponding author: Bousbaa, H.. "The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments". Molecular Biology of the Cell 19 4 (2008): 1798-1813. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949185572&partnerID=MN8TOARS.
    10.1091/mbc.E07-07-0633
  67. Orr, B.; Bousbaa, H.; Sunkel, C.E.. "Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells". Molecular Biology of the Cell 18 3 (2007): 850-863. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947132695&partnerID=MN8TOARS.
    10.1091/mbc.E06-07-0587
  68. Pérez-Mongiovi, D.; Malmanche, N.; Bousbaa, H.; Sunkel, C.. "Maternal expression of the checkpoint protein BubR1 is required for synchrony of syncytial nuclear divisions and polar body arrest in Drosophila melanogaster". Development 132 20 (2005): 4509-4520. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744507169&partnerID=MN8TOARS.
    10.1242/dev.02028
  69. Logarinho, E.; Bousbaa, H.; Dias, J.M.; Lopes, C.; Amorim, I.; Antunes-Martins, A.; Sunkel, C.E.. "Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells". Journal of Cell Science 117 9 (2004): 1757-1771. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342429609&partnerID=MN8TOARS.
    10.1242/jcs.01033
  70. Basu, J.; Bousbaa, H.; Logarinho, E.; Li, Z.; Williams, B.C.; Lopes, C.; Sunkel, C.E.; Goldberg, M.L.. "Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila". Journal of Cell Biology 146 1 (1999): 13-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033549477&partnerID=MN8TOARS.
    10.1083/jcb.146.1.13
  71. Basu, J.; Logarinho, E.; Herrmann, S.; Bousbaa, H.; Li, Z.; Chan, G.K.T.; Yen, T.J.; Sunkel, C.E.; Goldberg, M.L.. "Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod". Chromosoma 107 6-7 (1998): 376-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032441970&partnerID=MN8TOARS.
    10.1007/s004120050321
  72. Bousbaa, H.; Correia, L.; Gorbsky, G.J.; Sunkel, C.E.. "Mitotic phosphoepitopes are expressed in Kc cells, neuroblasts and isolated chromosomes of Drosophila melanogaster". Journal of Cell Science 110 17 (1997): 1979-1988. http://dx.doi.org/10.1242/jcs.110.17.1979.
    Published • 10.1242/jcs.110.17.1979
  73. Fratacci, MD; Levame, M; Rauss, A; Bousbaa, H; Atlan, G. "Rat diaphragm during postnatal development. I. Changes in distribution of muscle fibre type and in oxidative potential". Reproduction, Fertility and Development 8 3 (1996): 391. http://dx.doi.org/10.1071/rd9960391.
    Published • 10.1071/rd9960391
  74. Kouyoumdjian, C; Adnot, S; Levame, M; Eddahibi, S; Bousbaa, H; Raffestin, B. "Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats.". Journal of Clinical Investigation 94 2 (1994): 578-584. http://dx.doi.org/10.1172/jci117372.
    Published • 10.1172/jci117372
  75. Bousbaa, H.; Poron, F.; Fleury-Feith, J.. "Changes in chromogranin A-immunoreactive guinea-pig pulmonary neuroendocrine cells after sensitization and challenge with ovalbumin". Cell and Tissue Research 275 1 (1994): 195-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028039855&partnerID=MN8TOARS.
    10.1007/BF00305387
  76. Nakamura, Fumitaka; Kvasnicka, Jan; Levame, Micheline; Lange, Françoise; Bousbaa, Hassan; Geschwind, Herbert J.. "Acute response of the arterial wall to pulsed laser irradiation". Lasers in Surgery and Medicine 13 4 (1993): 412-420. http://dx.doi.org/10.1002/lsm.1900130404.
    Published • 10.1002/lsm.1900130404
  77. Bousbaa, Hassan; Fleury-Feith, Jocelyne. "Effects of a Long-standing Challenge on Pulmonary Neuroendocrine Cells of Actively Sensitized Guinea Pigs". American Review of Respiratory Disease 144 3_pt_1 (1991): 714-717. http://dx.doi.org/10.1164/ajrccm/144.3_pt_1.714.
    Published • 10.1164/ajrccm/144.3_pt_1.714
Journal issue
  1. Bousbaa, Hassan. "Special Issue: III TOXRUN International Congress abstract supplement 2024 | 02-03 May, 2024, Porto, Portugal". Scientific Letters 1 Sup 1 (2024): https://doi.org/10.48797/sl.2024.261.
    Published • https://doi.org/10.48797/sl.2024.261 • Editor
  2. Bousbaa, Hassan; Zhiwei, Hu. "Recent Advances in Anticancer Strategies". Pharmaceutics; Cancers; Biomedicines; Future Pharmacology (2024): https://www.mdpi.com/topics/A8U6WXLXT6.
    Invited editor
  3. Silva, Patrícia M. A.; Cidade, Honorina; Bousbaa, Hassan. "Special Issue "Bioactive Compounds in Cancers".". International Journal of Molecular Sciences (2023): https://www.mdpi.com/journal/ijms/special_issues/2I2VLC08N0.
    Accepted • Invited editor
  4. Bousbaa, Hassan. "Special Issue: II UNIPRO International Congress abstract supplement 2023 | 01-02 June, 2023, Porto, Portugal". Scientific Letters 1 Sup 2 (2023): https://doi.org/10.48797/sl.2023.112.
    Published • https://doi.org/10.48797/sl.2023.112 • Editor
  5. Bousbaa, Hassan. "Special Issue: II TOXRUN International Congress abstract supplement 2023 | 27-28 April, 2023, Porto, Portugal". Scientific Letters 1 Sup 1 (2023): https://doi.org/10.48797/sl.2023.111.
    Published • https://doi.org/10.48797/sl.2023.111 • Editor
  6. Bousbaa, Hassan. "Special Issue: "Novel Anticancer Strategies (Volume III)"". pharmaceutics (2023): https://www.mdpi.com/journal/pharmaceutics/special_issues/YZVK72LQGZ.
    Invited editor
  7. Bousbaa, Hassan. "Special Issue: "Novel Anticancer Strategies (Volume II)"". Pharmaceutics (2021): https://www.mdpi.com/journal/pharmaceutics/special_issues/novel_anticancer_volume_II.
    Published • Invited editor
  8. Bousbaa, Hassan. "Special Issue "Novel Anticancer Strategies"". Pharmaceutics 12 10 (2020): https://www.mdpi.com/journal/pharmaceutics/special_issues/novel_anticancer.
    Published • Invited editor
Thesis / Dissertation
  1. Bousbaa, Hassan. "Neurorendocrine cells of guinea pig lung: characterization and involvement in experimental allergic asthma. PhD Thesis". PhD, 1993. http://www.theses.fr/1993PA120034.
Website
  1. Bousbaa, Hassan; Gonçalves, Virgínia M. F.; Silva, Patrícia M. A.; Barbosa, Maria Joana; Azevedo, Rui M.S.. Corresponding author: Bousbaa, Hassan. Scientific Letters. 2022. https://publicacoes.cespu.pt/index.php/sl/index.

Other

Other output
  1. 443778/2023-0. A second opportunity to second-generation antimitotics for the treatment of lung cancer. Research proposal submitted to CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, for funding. Not funded. Team member. 2023. Bousbaa, Hassan.
  2. HR23-00213. The association between type 1 diabetes mellitus and periodontal diseases. Research proposal submitted to CaixaResearch Health 2023 for funding. Not funded. Team member. 2022. Bousbaa, Hassan.
  3. 2022.06056.PTDC. Chiral Flavonoids: enantioselectivity and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents. Proposal submitted to FCT for funding. 2022 call. Not funded. Team member. 2022. Bousbaa, Hassan.
  4. 2022.01567.PTDC. Creation of a drug test using ovarian cancer ascites-derived organoids. Proposal submitted to FCT for funding. 2022 call. Not funded. Team member. 2022. Bousbaa, Hassan.
  5. 2022.01407.PTDC. The association between type 1 diabetes mellitus and periodontal diseases. Proposal submitted to FCT for funding. 2022 call. Not funded. Team member. 2022. Bousbaa, Hassan.
  6. 2022.01974.PTDC. Bifunctionalized lipid probes to map lipid-lipid interactions in breast cancer cellular systems. Proposal submitted to FCT for funding. 2022 call. Not funded. Team member. 2022. Bousbaa, Hassan.
  7. 2022.02247.PTDC. The second-generation of antimitotics: new hope as anticancer agents?. Research proposta submitted for funding to FCT. Not funded. Principal Investigator. 2022. Bousbaa, Hassan.
  8. PTDC/MED-ONC/3136/2021. The second-generation of antimitotics: a second chance?. Proposal submitted to FCT for funding. Not funded. Principal Investigator. 2021. Bousbaa, Hassan.
  9. PTDC/MEC-EST/4352/2021. The association between type 1 diabetes mellitus and periodental diseases. Research proposal submitted to FCT for funding. Not funded. 2021. Bousbaa, Hassan.
  10. PTDC/QUI-QOR/2731/2021. 2D-Lipid tags as biomolecular tools for breast cancer detection. Research proposal submitted to FCT for funding. Not funded. Team member. 2021. Bousbaa, Hassan.
  11. EXPL/BTM-SAL/1304/2021. A novel polymeric saRNA cancer nanovaccine to reprogram immunologically the brain cancer microenvironment. Proposal submitted to FCT for funding. Not funded. Team member. 2021. Bousbaa, Hassan.
  12. PTDC/BIA-CEL/4442/2021. Controlo of Cell Proliferation. Researcher. Proposal submitted to FCT for funding. Not funded. Team member. 2021. Bousbaa, Hassan.
  13. PTDC/QUI-QOR/2896/2021. Xanthones and flavonoids: chirality and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents. Research proposal submitted to FCT for funding. Not funded. Team member. 2021. Bousbaa, Hassan.
  14. PTDC/MED-ONC/1360/2020. Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2020. Bousbaa, Hassan.
  15. C494249136-00091878. Proteome profiling of urine samples and genetic determinants of Portuguese patients infected with SARS-CoV-2. Research proposal submitted to FCT for funding. Not funded. Team member. 2020. Bousbaa, Hassan.
  16. PTDC/CTA-OHR/3912/2020. Natural products as antitumor agents: bioprospecting, synthesis and nanotechnological approaches to improve antitumor activity. Research proposal submitted to FCT for funding. Not funded. Team member. 2020. Bousbaa, Hassan.
  17. PTDC /QUI-QOR/5732/2020. Chiral derivatives of xanthones and flavonoids: an integrative strategy to discovery new drug candidates. Research proposal submitted to FCT for funding. Not funded. Team member. 2020. Bousbaa, Hassan.
  18. C492597698-00087532. Therapeutic targeting of cell division through nanoparticle-mediated siRNA delivery for the treatment of oral cancer. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2017. Bousbaa, Hassan.
  19. ATHEROME. Deciphering the atherosclerosis microbiome: key to precision medicine in cardiovascular field. Research proposal submitted to H2020-FETOPEN-1-2016-2017 for funding. Not funded. Team member. 2017. Bousbaa, Hassan.
  20. Fiberscar. Fabrication of long-term controlled drug delivery carriers of electrospun fibrous scaffolds for inhibiting hypertrophic scar. Research proposal submitted to FCT for funding. Not funded. Team member. 2016. Bousbaa, Hassan.
  21. Antimitotic Drugs. Encyclopedia of Cancer. 2014. Hassan Bousbaa; Bousbaa, Hassan. http://dx.doi.org/10.1007/978-3-642-27841-9_7074-1.
    10.1007/978-3-642-27841-9_7074-1
  22. PTDC/BIM-ONC/0195/2014. NanoAntiMito: Therapeutic targeting of cell division through functionalized nanoparticle-mediated siRNA delivery for the treatment of lung cancer. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2014. Bousbaa, Hassan.
  23. PTDC/BEX-BCM/0322/2012. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2012. Bousbaa, Hassan.
  24. PTDC/BIA-BCM/122717/2010. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2010. Bousbaa, Hassan.
  25. PTDC/BIA-BCM/110105/2009. Unveiling the molecular context of chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis of the human kinetochore. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2009. Bousbaa, Hassan.
  26. PTDC/BIA-BCM/098400/2008. Dissecting the role of spindle assembly checkpoint components in regulating chromosome-microtubule attachment. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2008. Bousbaa, Hassan.
  27. PIC/IC/83266/2007. Expression Analysis of Mitotic Checkpoint Genes and Prognostic Significance in Brain Cancer. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2007. Bousbaa, Hassan.
  28. PTDC/BIA-BCM/64172/2006. Role of mitotic checkpoint in aneuploidy: a brain tumor model. Research proposal submitted to FCT for funding. Not funded. Principal Investigator. 2006. Bousbaa, Hassan.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/04/08 Role of spindle assembly checkpoint proteins in oral carcinogenesis. 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU)
(Porto, Portugal)
2022/04/08 TARGETING BUB3 IN COMBINATION WITH PACLITAXEL INHIBITS PROLIFERATION OF GLIOBLASTOMA CELLS BY ENHANCING CELLULAR SENESCENCE. I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS
(Porto, Portugal)
2022/02/08 Mitosis as an anti-cancer target Ciclo de Conferências em Química Farmacêutica e Medicinal
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2021/11/25 Análise da expressão e potencial terapêutico da MPS1 no cancro oral. (Co-author/Supervisor) 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
(Benguela, Angola)
2021/11/25 ANALYSIS OF THE ANTITUMOR POTENTIAL OF THE COMBINATION OF AN MPS-1 INHIBITOR AND AN APOTOSIS INDUCER IN 2D AND 3D LUNG CANCER CELL CULTURES. (Co-auhtor/Supervisor) 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
(Benguela, Angola)
2021/11/25 EXPLORANDO A ATIVIDADE ANTITUMORAL DO COMPOSTO BP-M345. (Co-author/Supervisor) 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
(Benguela, Angola)
2021/11/25 Inibição da Bub3: uma estratégia promissora na potenciação do efeito antitumoral do Paclitaxel. (Coauthor/Supervisor) 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
(Benguela, Angola)
2021/11 Interferindo com a proteína p31comet aumenta a citotoxicidade do palitaxel e do Navitoclax em esferóides do cancro do pulmão. (Co-author/Supervisor) 4.ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia
(Benguela, Angola)
2020 POTENCIAÇÃO DA MORTE CELULAR INDUZIDA PELO NAVITOCLAX EM COMBINAÇÃO COM ANTIMITÓTICOS 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 A inibição da proteína p31comet sensibiliza as células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 INVESTIGANDO A ATIVIDADE ANTITUMORAL DO COMPOSTO XJS2 E SEU MECANISMO DE AÇÃO 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 AVALIAÇÃO DA ATIVIDADE ANTITUMORAL DE DERIVADOS XANTÓNICOS 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2019/11/20 New chalcone derivatives with antimitotic activity: synthesis, antitumor activity evaluation and chemosensitivity studies. XXV Encontro Galego-Portugues de Química
COLQUIGA & SPQ (Santiago de Compostela, Spain)
2019/07/18 Biological assessment of debris from oral implants. IX Workshop do IINFACTS
IINFACTS, CESPU (Gandra, Portugal)
2019/07/18 Biological assessment of debris from oral implants. IX Workshop do IINFACTS
IINFACTS, CESPU (Gandra, Portugal)
2019/05/17 Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations 4th Meeting on Medicinal Biotechnology
Escola Superior de Saúde do Porto (Porto, Portugal)
2019/05/17 Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations. 4th Meeting on Medicinal Biotechnology
Escola Superior de Saúde, Porto (Porto, Portugal)
2018/09/07 Antitumor Chalcone Derivatives: Synthesis and Biological Activity Evaluation. IJUP 2018, 11º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2018/07/20 Targeting cell division to kill cancer cells. VIII Workshop do IINFACTS
IINFACTS, CESPU (Porto, Portugal)
2018/07/19 Targeting cell division to kill cancer cells. VIII Workshop do IINFACTS
IINFACTS, CESPU (Gandra, Portugal)
2018/03/07 Chalcone Derivatives with Potential Antitumor Activity: Synthesis and Antimitotic Activity Evaluation. National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting
Faculty of Pharmacy of the University of Porto (Porto, Portugal)
2017/09/14 2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies. 12th YES (Young European Scientist) Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)
2017/07/20 A Proteína Mitótica Spindly como Alvo Terapêutico contra o Cancro. VII Workshop do IINFACTS
IINFACTS, CESPU (Gandra, Portugal)
2017/02/08 Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies. IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2016/07/01 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents. VI Workshop do IINFACTS
IINFACTS, CESPU (Gandra, Portugal)
2015/05/13 Evaluation of the antimitotic activity of a new prenylated chalcone in NCI-H460 non-small cell lung cancer cells. IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2015/05/13 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of glioblastoma cells to anti-mitotic agents. IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2015/05/13 Targeting Cdc20 protein to increase sensitivity of colorectal cancer cells to paclitaxel. IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (POrto, Portugal)
2015/05/13 A new prenylated chalcone induces mitotic arrest and cell death by mitotic catastrophe in MCF-7 breast cancer cell line. IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2014/11/06 Live dividing cells under the microscope. INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society
Faculty of Engineering of the University of Porto (Porto, Portugal)
2014/11/06 Tracking dynein-mediated transport of spindle assembly checkpoint proteins from kinetochore to spindle pole. INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society
Faculty of Engineering of the University of Porto (POrto, Portugal)
2012/09/21 Identification of a compound that induces mitotic catastrophe in MCF-7 breast cancer cells. 5th Workshop CICS-UnIPSa-CITS
Cooperativa de Ensino Superior Politécnico e Universitário (Gandra, Portugal)
2011/10/22 Investigação em Ciências Dentárias na CESPU XXXI Congresso Anual da SPEMD (Sociedade Portuguesa de Estomatologia e Medicina Dentária)
Universidade de Coimbra (Coimbra, Portugal)
2010/09/08 Estudos de Expressão de Genes do Checkpoint Mitótico em Linhas Tumorais 3th Workshop CICS-UnIPSa-CITS
Cooperativa de Ensino Superior Politécnico e Universitário (Gandra, Portugal)
2009/09/10 Estudos de Expressão de Genes do Checkpoint Mitótico em Linhas Tumorais II Workshop CICS-UnIPSa-CITS
Cooperativa de Ensino Superior Politécnico e Universitário (Gandra, Portugal)
2008/07/24 Centro de Investigação em Ciências da Saúde Centro de Investigação em Ciências da Saúde
1º Workshop CICS-UNIPSA-CITS (Gandra, Portugal)
2008/02/20 Analysis of the efficiency of the mitotic checkpoints in glioblastoma cell lines. IJUP, I Encontro de Jovens Investigadores da Universidade do Porto
University of Porto (Porto, Portugal)
2006/12/02 The role of the human spindle checkpoint proteins Bub3, Bub1 and BubR1 in kinetochore-microtubule attachments: a comparative analysis. XV Nacional Congress of Biochemistry
University of Aveiro (Porto, Portugal)
1992/07/07 Pulmonary neuroencocrine cells in experimental allergic asthma. XIXème Forum des jeunes chercheurs de la Société de Biochimie et de Biologie Moléculaire
Univerisity of Caen (Caen, France)
1992 Pulmonary neuroendocrine cells : role in experimental asthma in guinea pig 74ème Congrès de l’association des anatomistes
(Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current The vast world of Microtubule Targeting Agents and their new analogues in chemotherapy
Co-supervisor of Henrique Carvalho Assunção
 Química Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/12/01 - Current Stress and Burnout syndrome in Anesthesiologists
Co-supervisor of Antonieta Joaquim Bravo da Costa Tomás
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/11/01 - Current Nature-inspired chiral flavonoids as potential antitumor agents: a mindset-shifting strategy to achieve eco-friendly drugs
Co-supervisor of Cláudia Sofia Ferreira Pinto
 Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/02/01 - Current The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential
Supervisor of João Pedro Nunes Silva
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2021 - Current Improving the efficacy of immunotherapy in endometrial cancer patients by combining epigenetic drugs and using patient-derived spheroid cocultures
Co-supervisor of Pedro Novais
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2020/02 - Current Three-dimensional models of cancer to increase the predictive value of preclinical evaluation of antimitotic agents
Supervisor of Bárbara Fernandes Pinto
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/02 - Current 3D tumor spheroids as preclinical models to study oral Cancer
Supervisor of Mafalda Maria Calheiros Lobo Duarte Pinto Guimarães
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018 - Current Citotoxicidade de produtos de degradação libertados de miniimplantes ortodônticos.
Supervisor
 Ciências Biológicas Aplicadas à Saúde (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2023/09/01 - 2024/07/31 Targeting Eg5 and BCL-2 to overcome paclitaxel resistance in ovarian cancer (defended with 19/20)
Supervisor of Carina Isabel Ribeiro Gomes
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023/09/01 - 2024/07/31 Targeting Mps1 and BCL-XL/BCL-2 to overcome paclitaxel resistance in ovarian cancer
Supervisor of Francisca Nazaré de Mesquita Sampaio
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/09/01 - 2023/07/15 Characterization of cytotoxic mechanism of new molecules with antitumor potential
Supervisor of Eliseba Castro
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017/01 - 2022/11/04 Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs.
Supervisor of Ana Cristina do Espírito Santo Henriques
 Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020 - 2021/12/16 Cell fates after combined treatment with second generation antimitotics and apoptosis potentiators
Supervisor of Pedro Henrique Alves Novais
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2020 - 2020 Toxicity of debris released from oral endosseous implants.
Co-supervisor of Redouane Messous Haida
 Medicina Dentária (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020 Improving the antitumor efficacy of antimiotic agents
Supervisor of Joseph Justin Maroun Karam
 Ciências Biomédicas (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020 Evaluation of antitumor activity of a small molecule
Supervisor of Bárbara Ferreira
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020 Evaluation of antitumor activity of a small molecule
Supervisor of Daniela Sofia
Ciências Biomédicas (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020 INVESTIGATING THE ANTITUMORAL ACTIVITY AND MECHANISM ACTION OF THE A XANTHONE DERIVATIVE
Supervisor of Fábio França Vieira e Silva
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2018 - 2019 Screening for anticancer activity of novel small molecules
Supervisor of Andrea Bocos Baelo
Ciências Faramcêuticas (Other)
Universitat de Barcelona Facultat de Farmacia, Spain
2018 - 2019 Screening for anticancer activity of novel small molecules
Supervisor of Pilar Araujo Casal
Ciências Farmacêuticas (Other)
Universitat de Barcelona Facultat de Farmacia, Spain
2017 - 2018 Avaliação da atividade anti tumoral de pequenas moléculas de origem natural e sintética
Supervisor of Rita Madalena Pinto Moreira
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2018 Avaliação da atividade anti tumoral de pequenas moléculas de origem natural e sintética
Supervisor of Tatiana Canelas Ferreira
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2017 Avaliação da atividade anti tumoral de pequenas moléculas de origem natural e sintética
Supervisor of Joana Raquel Rodrigues Pinto
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2017 Avaliação da atividade anti tumoral de pequenas moléculas de origem natural e sintética
Supervisor of André Filipe Lino Furtado
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2016 - 2017 Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama
Supervisor of José Diogo Almeida
Bioquímica (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2013 - 2017 THE SPINDLE ASSEMBLY CHECKPOINT: NEW INSIGHTS INTO ITS FUNCTION, REGULATION AND THERAPEUTIC IMPLICATIONS
Supervisor of PATRÍCIA MANUELA AREIAS DA SILVA
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2011 - 2016 Innovative functional polymer therapeutic nanotechnologies for siRNA delivery in lung cancer
Co-supervisor of Ana Vanessa Hortas do Nascimento
 Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 Screening for small molecules with potential antitumour activity and characterization of the antimitotic activity of a prenylated chalcone in NCI-H460 non- small cell lung cancer cells
Supervisor of Joana Cristina Rodrigues da Fonseca
 Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015 Screening and identification of samll molecules with potential antitumour activity and insight into the mechanism of action of a prenylated chalcone in MCF-7 breast cancer cells
Supervisor of Sandra Isabel Barbosa Marques
 Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2014 - 2015 Interferindo com o "checkpoint" mitótico para potenciar a ação de agentes anti-mitóticos
Supervisor of Joana Filipa Tomás Teixeira
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2014 - 2015 Checkpoint mitótico como alvo terapêutico para sensibilizar células cancerígenas a agentes antimitóticos
Supervisor of Vânia Sofia dos Reis Diogo
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2014 - 2014 Expression analysis of mitotic checkpoint genes in oral cancer
Supervisor of José Henrique Carvalho Teixeira
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014 Exploring CDC20 gene expression in oral cavity cancer
Supervisor of Inês Moranguinho Bastardo Moura
 Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2010 - 2011 Interfering with mitosis through nanoparticles-encapsulated siRNAs
Supervisor of Susana Filipa Alves Silva
 Biologia Molecular e Celular (Master)
Universidade de Aveiro, Portugal
2009 - 2011 Relationship between the mitotic checkpoint protein Bub3 and the motor protein Dynein during kinetochore to microtubule attachment
Supervisor of Patrícia Manuela Areias da Silva
 Técnicas de Biologia Molecular e Citómica nas Ciências da Saúde (Master)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2008 - 2009 Functional and molecular characterization of the mitotic checkpoint in oral cancer cell lines
Supervisor of Íris Ferreira
 Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2008 - 2009 Expression profile of mitotic checkpoint genes in oral cancer cell lines
Supervisor of Daniela Ribeiro
 Bioquímica (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2008 - 2009 Expression profile of mitotic checkpoint genes in oral cancer cell lines
Supervisor of Cristiana Carvalho
 Bioquímica (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2007 - 2008 Interfering with mitotic checkpoint gene expression in tumour cells
Supervisor of Kelly Laurence
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2007 - 2008 Functional and molecular characterization of the mitotic checkpoint in glioblastoma cancer lines
Supervisor of Vanessa Nascimento
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2007 - 2008 Functional and molecular characterization of the mitotic checkpoint in medulloblastoma cancer lines
Supervisor of Joana Barbosa
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2007 - 2008 Analyzing the competence of the mitotic checkpoint in oral cancer lines
Supervisor of Juliana Faria
 Biologia (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2006 - 2007 Interfering with mitotic checkpoint gene expression in tumour cells
Supervisor of Vanessa Nascimento
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2006 - 2007 Genes involved the mitotic checkpoint
Supervisor of Cláudia Torres
 Research Fellowship (Other)
Fundação para a Ciência e a Tecnologia, Portugal
2005 - 2006 Genes involved the mitotic checkpoint
Supervisor of Tatiana Resende
 Research fellowship (Other)
Fundação para a Ciência e a Tecnologia, Portugal
2004 - 2005 Genes involved the mitotic checkpoint
Supervisor of Joana Ribeiro
 Research fellowship (Other)
Fundação para a Ciência e a Tecnologia, Portugal
2001 - 2002 Molecular characterization of a drosophila BubR1 mutant allele
Co-supervisor of Eliana Real
 Programa Gulbenkian de Doutoramento em Medicina e Biologia (Other)
Instituto Gulbenkian de Ciência, Portugal
2000 - 2001 Phenotype characterization of a drosophila BubR1 mutant allele
Supervisor of Madalena Costa
 Anatomia Patológica, Citológica e Tanatológica (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2000 - 2001 Isolation and characterization of the mitotic checkpoint gene Mad2 in drosophila melanogaster
Co-supervisor of Ana Martins
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
1997 - 1998 isolation and characterization of the Nek2 homolog in drosophila melanogaster
Co-supervisor of Luísa Figueiredo
 Bioquímica (Degree)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1996 - 1997 Isolation and characterization of a new synaptotagmin isoform in drosophila melanogaster
Co-supervisor of Catarina Lemos
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/04/07 - Current 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU) (2022/04/07 - 2022/04/08)
Congress (Other)
 Instituto Universitário de Ciências da Saúde, Portugal
2019/10 - Current PhD Day (Annual) (2019/10)
Workshop (President of the Organising Committee)
 Instituto Universitário de Ciências da Saúde, Portugal
2022/04/07 - 2022/04/08 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU) (2022/04/07 - 2022/04/08)
Congress (Member of the Organising Committee)
 Instituto Universitário de Ciências da Saúde, Portugal
2020/03/26 - 2020/03/28 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – rRACS (2020 - 2020)
Meeting (Member of the Scientific Committee)
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Universidade do Minho, Portugal

Escola Superior de Enfermagem do Porto, Portugal

Escola Superior de Saúde da Cruz Vermelha Portuguesa, Portugal

Instituto Piaget, Portugal

Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal

Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Instituto Superior de Saúde do Alto Ave, Portugal

Universidade Católica Portuguesa, Portugal
2016 - 2020 Workshop do IINFACTS (Annual) (2016 - 2020)
Workshop (President of the Organising Committee)
 Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2008 - 2012 1st to 5th Workshop cics-unipsa-cits (Annual) (2008 - 2012)
Workshop (President of the Organising Committee)
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2012/09/28 - 2012/09/28 Research in Cancer
Exhibition
 Noite Europeia dos Investigadores
Plataforma das Artes, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/11/04 Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs
Supervisor
 Ana Cristina do Espírito Santo Henriques (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2022/10/17 Minimally invasive aesthetic rehabilitation of cases of maxillary lateral incisor agenesis: chemical-mechanical behavior
President of the jury
 Lígia Lopes da Rocha (PhD)
Instituto Universitário de Ciências da Saúde, Portugal
2022/10/06 Seeking optimized TAp73-targeting agents for neuroblastoma treatment
(Thesis) Main arguer
 Inês Maria Ferreira da Mota (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/21 Theranostic Nanocomposites for Cancer Immunotherapy
Thesis Member
 Tomás Bauleth Quinta Ferreira Ramos (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/03/20 Functional Dissection of Dynein Cofactors in Mitosis
(Thesis) Arguer
 Patrícia Alexandra Carvalho Simões (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/15 The spindle assembly checkpoint: new insights into its function, regulation and therapeutic implications
Supervisor
 Patrícia Manuela Areias da Silva (PhD)
Universidade do Algarve, Portugal
2017 CHARACTERIZATION OF BACTERIA ISOLATED FROM TOBACCO AND LUNG CANCER BIOPSIES AND THEIR ENVIRONMENT: BIOFILM FORMATION AND PORE-FORMING PROTEINS
Thesis Member
 Alexandra Merlos Gil (PhD)
Universitat de Barcelona Facultat d'Odontologia, Spain
2016/05/23 Innovative functional polymer therapeutic nanotechnologies for siRNA delivery in lung cancer
Supervisor
 Ana Vanessa Hortas do Nascimento (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/12/16 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents
Supervisor
 Joana Teixeira (Master)
Universidade do Algarve, Portugal
2015/12/15 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents
Supervisor
 VÂNIA SOFIA DOS REIS DIOGO (Master)
Universidade do Algarve, Portugal
2015/10/28 Screening for small molecules with anti-mitotic activity
Supervisor
 Sandra Isabel Barbosa Marques (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2015/10/26 Screening for small molecules with potential antitumour activity and characterization of the antimitotic activity of a prenylated chalcone in NCI-H460 non- small cell lung cancer cells
Supervisor
 Joana Cristina Rodrigues da Fonseca (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2014/11/21 Mitotic checkpoint proteins and oral squamous cell carcinoma: expression levels and prognostic value
Supervisor
 José Henrique Carvalho Teixeira (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/01/31 Exploring the CDC20 gene expression in oral cavity cancer
Supervisor
 Inês Moranguinho Bastardo Moura (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2012/04/17 Molecular regulation of human CLASPs during the cell cycle
Thesis Member
 Ana Rita Ramada Maia (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2011 Relationship between the mitotic checkpoint protein Bub3 and the motor protein Dynein during kinetochore to microtubule attachment
Supervisor
 Patrícia Silva (Master)
Instituto Politécnico de Saude do Norte Escola Superior de Saúde do Vale do Sousa, Portugal
2011 Interfering with mitosis through nanoparticles-encapsulated siRNAs
Supervisor
 Susana Silva (Master)
Universidade de Aveiro, Portugal
2009 Pathways involved in skeletal muscle glucose uptake induced by contraction and insulin: the role of atypical protein kinase
(Thesis) Main arguer
 Júlia Matzenbacher dos Santos (PhD)
Universidade do Porto Faculdade de Desporto, Portugal
2009 Functional and molecular characterization of the mitotic checkpoint in oral cancer cell lines
Supervisor
 Íris Ferreira (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2008 Analyzing the competence of the mitotic checkpoint in oral cancer lines
Supervisor
 Juliana Faria (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2008 Functional and molecular characterization of the mitotic checkpoint in medulloblastoma cancer lines
Supervisor
 Joana Barbosa (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2008 Functional and molecular characterization of the mitotic checkpoint in glioblastoma cancer lines
Supervisor
 Vanessa Nascimento (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2008 Interfering with mitotic checkpoint gene expression in tumour cells
Supervisor
 Kelly Laurence (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2005 Phenotypic and Molecular Characterization of the Mast V40 Mutant: a Gene Involved in Cell Division
(Thesis) Main arguer
 Catarina Lídia de Almeida Rodrigues Lemos (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Conference scientific committee

Conference name Conference host
2022/10/13 - 2022/10/15 XXVIII Congresso da Sociedade Portuguesa de Ortodontia Sociedade Portuguesa de Ortodontia
2022/06/03 - 2022/06/04 XVII Congresso Nacional de Podologia APP – Associação Portuguesa de Podologia

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/11/07 - Current Biomolecular and Cellular Bases Ciências Biomédicas (Doutoramento) Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022/02/08 - Current Mitosis as anti-cancer target (Ciclo de Conferências em Química Farmacêuticas e Medicinal) Química Farmacêutica (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2017/11/02 - Current Cell Biology of Tooth Movement Post Graduate Course in Orthodontics (Specialization) (Especialização pós-licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2015 - Current Advanced Course in Oncobiology (Coordination and Teaching) Ciências Biomédicas (Doutoramento) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2015 - Current Thesis Project (Coordination and Teaching) Ciências Biológicas Aplicadas à Saúde (Doutoramento) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2015 - Current Thesis (Coordination and Tutorial Teaching) Ciências Biológicas Aplicadas à Saúde (Doutoramento) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2013 - Current Cellular and Molecular Biology (Coordination and Teaching) Ciências Biomédicas (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário Escola Universitária de Bragança, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2012 - Current Clinical Oncobiology (Coordination and Teaching) Análises Clínicas (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2008 - Current Advanced course in Molecular Pathology (Coordination and Teaching) Terapias Moleculares (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
1998 - Current Cellular and Molecular Biology I (Coordination and Teaching) Ciências Dentárias (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
1998 - Current Cellular and Molecular Biology II (Coordination and Teaching) Ciências Dentárias (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2012 - 2018 Cell Biology (Coordination and Teaching) Ciências da Nutrição (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2006 - 2018 Cellular and Molecular Biology (Coordination and Teaching) Bioquímica (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
1998 - 2018 Cell Biology (Coordination and Teaching) Ciências Farmacêuticas (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
1998 - 2008 Cell Biology (Coordination and Teaching) Clinical Psychology (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
1998 - 2007 Spindle Assembly checkpoint (Theory and Practice) Doctoral Program in Areas of Basic and Applied Biology (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/02/24 - 2006/02/24 Seminar "Targeting mitosis to kill cancer cells" Química Farmacêutica (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
1995 - 1998 Spindle Assembly Checkpoint (Theory and Practice) Programa Gulbenkian de Doutoramento em Medicina e Biologia (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018 - Current Grant Reviewer
Evaluator
 Belgian Foundation against Cancer, Belgium Belgian Foundation against Cancer
2015 - Current Grant Reviewer
Evaluator
 Wellcome Trust, United Kingdom
2012 - Current Grant Reviewer
Evaluator
 Fonds de la Recherche Scientific, Belgium
2010 - Current Grant Reviewer
Evaluator
 Association for International Cancer Research, United Kingdom
2008 - Current Grant Reviewer
Evaluator
 Agence nationale de la recherche, France
2005 - Current Grant Reviewer
Evaluator
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal Cooperativa de Ensino Superior Politécnico e Universitário
2022/04/04 - 2022/04/22 Teacher performance evaluation
Evaluator
 Instituto Universitário de Ciências da Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017 Inibição de proteína associada à divisão celular ajuda no tratamento do cancro - estudo Diário de Notícias
2017 Investigadores do Porto descobrem como levar as células cancerígenas ao "suicídio" SIC Notícias
2017 Eliminação da Spindly: um gatilho para o suicídio de células cancerígenas ASPIC
2017 Smart nanoparticles to overcome resistance to chemotherapy ASPIC
2017 Expressão da EMMPRIN em carcinomas epidermoides orais: associação com a proliferação tumoral e com a sobrevivência ASPIC

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Scientific Reports (2045-2322) Springer Nature
2022 - Current Drug Resistance Updates (1368-7646) Elsevier
2021 - Current BMC Oral Health (14726831) BioMed Centra
2020 - Current Cancers (2072-6694) MDPI
2020 - Current Annals of Oncology (1569-8041) Elsevier
2019 - Current Cellular Physiology and Biochemistry (1421-9778) Cell Physiol Biochem Press GmbH and Co KG
2019 - Current EBioMedicine (2352-3964) Elsevier
2019 - Current Pharmaceutics (1999-4923) MDPI AG
2018 - Current Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (1874-9399) Elsevier
2018 - Current Biological Chemistry (1437-4315) Walter de Gruyter GmbH
2018 - Current Biomedicine & Pharmacotherapy (0753-3322) Elsevier
2018 - Current Journal of Clinical Medicine (2077-0383) MDPI AG
2018 - Current Nanomaterials (2079-4991) MDPI AG
2018 - Current Pathology - Research and Practice (0344-0338) Elsevier
2017 - Current Current Medicinal Chemistry (0929-8673) Bentham Science
2017 - Current European Journal of Pharmaceutical Sciences (0928-0987) Elsevier
2017 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2017 - Current International Journal of Nanomedicine (1178-2013) Dove Medical Press
2017 - Current Marine Drugs (1660-3397) MDPI AG
2017 - Current Molecular Diagnosis & Therapy (1179-2000) Springer-Verlag
2017 - Current Oncotarget (1949-2553) "Impact Journals, LLC "
2017 - Current OncoTargets and Therapy (1178-6930) Dove Medical Press
2016 - Current BioMed Research International (2314-6141) Hindawi Limited
2016 - Current ecancermedicalscience (1754-6605) Ecancer Global Foundation
2016 - Current FEBS Letters (1873-3468) Wiley (John Wiley & Sons)
2016 - Current Journal of Cancer Science and Clinical Oncology (2394-6520) "Annex Publishers, LLC"
2016 - Current Medical Science Monitor Basic Research (2325-4416) "International Scientific Information, Inc."
2016 - Current Molecular Biology Reports (1573-4978) Springer-Verlag
2016 - Current PeerJ (2167-8359) PeerJ
2015 - Current BMC Cancer (1471-2407) Springer (Biomed Central Ltd.)
2015 - Current Computational and Structural Biotechnology Journal (2001-0370) Elsevier
2014 - Current Cancer Letters (0304-3835) Elsevier
2014 - Current Frontiers in Physiology (1664-042X) Frontiers Media SA
2014 - Current International Journal of Molecular Sciences (1422-0067) MDPI AG
2014 - Current Molecules (1420-3049) MDPI AG
2011 - Current Gene (0378-1119) Elsevier
2010 - Current Cell Proliferation (1365-2184) Wiley (Blackwell Publishing)
Distinctions

Award

2023 Prémio Anual de Produtividade Científica (Annual Scientific Productivity Award)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2022 Prémio Anual de Produtividade Científica (Annual Scientific Productivity Award)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2021 Prémio Anual de Produtividade Científica (Annual Scientific Productivity Award)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009 1st Best Poster presented at "III Jornadas das Ciências do Instituto Superior de Ciências da Saúde - Norte, CESPU"
Instituto Universitário de Ciências da Saúde, Portugal
2008 1st Best Poster presented at III Jornadas das Ciências do Instituto Superior de Ciências da Saúde - Norte, CESPU
Instituto Universitário de Ciências da Saúde, Portugal
2007 CESPU International Research Award, 2nd Edition, 3rd Prize
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2007 2nd Best Poster presented at "I Jornadas das Ciências do Instituto Superior de Ciências da Saúde - Norte, CESPU"
Instituto Universitário de Ciências da Saúde, Portugal
1996 Postdoctoral fellowship (2) at Instituto de Biologia Molecular e Celular (IBMC)
Fundação para a Ciência e a Tecnologia, Portugal
1994 Postdoctoral fellowship (1) at Instituto de Biologia Molecular e Celular (IBMC)
The Human Capital and Mobility Program of the European Commission, Belgium
1989 PhD fellowship at the University Paris-Est Creteil
Moroccan Foundation for Advance Science Innovation and Research, Morocco