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Catarina Brito is the Principal Investigator (tenure) of ITQB NOVA. She has been the Head of the Advanced Cell Models Lab of iBET and ITQB NOVA since 2014; currently leading a team of 15 researchers: 6 post-docs, 5 PhD students (individual grants), 2 MSc research fellows, and 2 MSc students. C Brito’s research focuses on microenvironment-driven modulation of disease progression and targeted therapy responses, through the development and interrogation of in vitro and ex vivo models of the disease microenvironment (emphasis on immunosuppressive breast carcinomas and high-grade gliomas; and other CNS pathologies). Currently, her team investigates myeloid cell-driven inflammatory and immunosuppressive microenvironments, along 2 central research lines: 1. Neuron-glia crosstalk in neuroinflammation and early tissue response to viral vectors; 2. Macrophage-tumor cell crosstalk in immunosuppression and resistance to immunomodulatory therapies. The group has pioneered cell-based strategies to tackle challenges in the imminent areas of cancer immunotherapies and viral vector-based gene therapies. Background: PhD in Biochemistry & Cell Biology (2007), by ITQB-NOVA (PT) and Degree in Biochemistry (2001, University of Lisbon). PhD training - glycobiology and intracellular trafficking in human cells, Glycobiology Lab (ITQB-NOVA) and Membrane Traffic in Neuronal & Epithelial Morphogenesis Lab (Institut Jacques Monod, France). Postdoctoral training in stem cell biotechnology and cell-based assay development (iBET, PT). Funding: PI/co-PI of 18 projects + team member of 31 projects, funded by FCT (5+12), EC and Innovative Medicines Initiative (EC & EFPIA) (2+9); iNOVA4Health (PT) and iBET internal calls (7+10), and the Pharmaceutical Industry (4 as PI). Productivity: 83 articles in peer-reviewed journals, 26 as senior/corresponding author, and 8 book chapters; h-index=28 (Scopus), over 3500 citations. Invited lectures in conference cycles and international courses, academic (22) and industrial (7); Invited lecturer in international conferences (49), of over 100 oral communications and 150 posters as presenting/corresponding. Supervision/co-supervision: PhD theses- 16 (12 concluded+1 submitted); MSc theses: 15 (14 concluded). Postdoctoral fellows & senior researchers: 10. Teaching & advanced training: Member of the Executive Committee of MolBioS: PhD program in Molecular Biosciences (coordinated by ITQB NOVA); Coordinator of the Biopharmaceutical Technology Profile, 2013-2022; Coordinator of the Curricular Unit, Tools for Discovery and Preclinical Research, since 2013; Co-coordinator of the ESACT Drug Discovery Course, Costa Brava, Spain, 2015 – 2022; Regular lecturer in MSc and PhD programs in Biomedicine and Bioengineering. Other duties: Chair Scientific Board, Analytical Services Unit (iBET, 2015-2018); Co-administrator of the Science & Services Section of the Animal Technology Unit, iBET (2012-2021); Management Board of the iNOVA4Health Research Unit: member (2018-23); ITQB NOVA representative (since 2024); Coordinator of the Science and Technology of Stem Cells Section of the Portuguese Society for Stem Cells and Cell Therapies (2018-2021); Member of the Division of Biopharmaceutical and Medical Biotechnology of EFB (European Federation of Biotechnology) Evaluation Committees: EU Joint Programme Neurodegenerative Disease Research (JPND, 2017, 2018, 2024); Novel Experimental Models for Cancer Research: optimization of 3R (2019, 2002), AVIESAN, Inserm; Research Council of Norway (since 2020); co-coordinator of the Biochemistry & Experimental Biology panel, FCT call PhD fellowships (2022). Regular expert reviewer: RCUK, Breast Cancer Now, UK Research & Innovation (UK); FWO (Belgium); STW (Netherlands); ANR, Inserm (France). Editorial Board Member: Scientific Reports; Invited Editor: Scientific Reports; Frontiers in Immunology; Review Editor in several journals.
Identification

Personal identification

Full name
Ana CATARINA Maurício BRITO Ataíde Montes
Gender
Female

Citation names

  • Catarina Brito

Author identifiers

Ciência ID
7C16-D64C-9CF8
ORCID iD
0000-0002-8926-279X
Google Scholar ID
https://scholar.google.com/citations?user=szZhQl4AAAAJ&hl=en
Researcher Id
A-2389-2009
Scopus Author Id
7007023897

Addresses

  • iBET. Apartado 12, 2780-901 O, Oeiras, Oeiras, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018
Concluded
Bioengenharia (Doutoramento)
Major in Sem especialidade
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
"Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer" (THESIS/DISSERTATION)
2017
Ongoing
Bioengenharia (Doutoramento)
Major in Especialidade: Bioengenharia - Terapias Celulares e Medicina Regenerativa
Universidade de Lisboa Instituto Superior Técnico, Portugal
"The impact of the genetic risk factor Bin1 to Alzheimer’s disease development" (THESIS/DISSERTATION)
2007/10/19
Concluded
Bioquímica (Doutoramento)
Major in Especialidade: Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Fucosyltransferase IX: Characterization and Biological Role" (THESIS/DISSERTATION)
approved by unanimity
2001/10/01
Concluded
Bioquímica (Licenciatura)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
"Importance of the transmembrane domain of human fucosyltransferase III for its Golgi localization and in vivo activity (20/20)" (THESIS/DISSERTATION)
16/20
Affiliation

Science

Category
Host institution
Employer
2020/07/01 - Current Principal Investigator (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
2018/09/01 - 2020/06/30 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
2014/07/01 - 2018/08/31 Contracted Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
2009/07/01 - 2014/06/30 Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
2007/11/01 - 2009/06/30 Postdoc (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
2001 - 2003 Research Assistant (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2000 - 2001 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Others

Category
Host institution
Employer
2013/09/01 - 2013/10/31 Visiting Researcher Harvard Medical School, United States
2003 - 2007/10 PhD student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2006 Visiting PhD student Institut Jacques Monod, France
Projects

Grant

Designation Funders
2020/10/01 - 2025/10/31 Accelerating Research and Innovation for Advanced Therapies (ARDAT)
Principal investigator
Innovative Medicines Initiative (IMI)
Ongoing
2020/01/01 - 2024/12/31 Neurospheroids to model pathological neuroinflammation
10.54499/UIDB/04462/2020
Principal investigator
iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/07/01 - 2024/12/01 Depicting the tumour associated macrophage phenotype employing 3D breast cancer cell models
10.54499/UIDP/04462/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2021/11/01 - 2024/10/30 Glyco-TAM: Cracking glycan-lectin interactions to target immunosuppressive macrophages in triple-negative breast cancer
PTDC/BTM-ORG/0971/2020
Principal investigator
iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2024 The effect of dual HER2 blockade on anti-tumor immune cells
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
iNOVA4Health
Ongoing
2018/01/01 - 2021/12/31 Patient-derived ex vivo ovarian cancer models to explore tumour microenvironment driven drug resistance in ovarian cancer
--
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
AbbVie Inc
Concluded
2018/10 - 2021/09 AstroReact - Unravelling the role of astrocyte-induced neural microenvironment remodelling in traumatic brain injury pathobiology
PTDC/BTM-ORG/29580/2017
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal

Institut de Ciències Fotòniques, Spain
Fundação para a Ciência e a Tecnologia
2017 - 2020 Do genetic variants in CD2AP increase the risk of developing Alzheimer’s disease?
Collaborator
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
iNOVA4Health
Ongoing
2017 - 2019 Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs
Collaborator
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/09 - 2017/08 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2016 PREDECT - New Models for preclinical evaluation of drug efficacy in common solid tumors
Principal investigator
Instituto de Biologia Experimental e Tecnológica, Portugal
Innovative Medicines Initiative
Concluded
2013/07 - 2015/12 Combining siRNA and AAV therapy approaches to target human basal-like breast cancer: from vector development to anti-tumor efficacy evaluation.
Researcher
Stichting Weten

Fundação para a Ciência e a Tecnologia, I.P.
2012/02 - 2015/07 Smart particles for drug delivery to the colon and to the liver
Researcher
Stichting Weten

Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03 Microfluidics light-sheet microscopy for increased throughput analysis of 3D cell models and zebra-fish
Researcher
Stichting Weten

Fundação para a Ciência e a Tecnologia, I.P.
2012/03 - 2015/02 Human central nervous system in vitro models for preclinical research: new tools for studying viral vector-mediated gene delivery in 3D cell context
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.

Stichting Weten
2011/03 - 2014/08 3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity
Principal investigator
Stichting Weten

Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2013/05 2D fluorometry: a powerful tool to improve mammalian cell process development
Post-doc
Fundação para a Ciência e a Tecnologia, I.P.

Stichting Weten
2010/03 - 2013/02 BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production.
Post-doc
Fundação para a Ciência e a Tecnologia, I.P.
2009 - 2012 Hyperlab: High Yield and Performance Stem Cell Lab
223011
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal

Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV, Germany
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2008 - 2012 BrainCAV: Nonhuman adenovirus vectors for gene delivery to the Brain
HEALTH-F5-2008-222992
Researcher
Instituto de Biologia Experimental e Tecnológica, Portugal

Institut de Génétique Moléculaire Montpellier, France

Cancer Research UK, United Kingdom
European Commission Sixth Framework Programme
Concluded
2009/01 - 2011/12 Integrated strategy for expansion, neuronal differentiation and cryopreservation of human embryonic stem cells
Post-doc
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2007/11/01 - 2009/06/30 NEURONAL DIFFERENTIATION OF THE HUMAN EMBRYONAL CARCINOMA STEM CELL LINE NTERA2/CL.D1 IN NANOSTRUCTURED SURFACES
SFRH/BPD/34622/2007
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2009 CellPROM - Cell Programming by Nanoscaled Devices
NMP4-CT-2004-500039
Post-doc
Instituto de Biologia Experimental e Tecnológica, Portugal
European Commission Sixth Framework Programme
Concluded
2004 - 2007 STREP - Signaling and Membrane Trafficking in Transformation and Differentiation
LSHG-CT-2004-503228
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Institut Jacques Monod, France
European Commission Sixth Framework Programme
Concluded
2002/10/01 - 2006/09/30 IMPORTANCE OF PROTEIN-PROTEIN INTERACTIONS FOR GOLGI RETENTION OF GLYCOSYLTRANSFERASES
SFRH/BD/9139/2002
Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2001 Glicosilação das mucinas na mucosa gástrica normal, carcinoma gástrico e linhas celulares de carcinoma gástrico: papel da glicosilação e das apomucinas
PRAXIS/SAU/14111/1998
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

BioResources 4 Sustainability, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Deciphering immunosuppressive events in Diffuse Midline Glioma (DMG) employing a 3D cell model of the tumor microenvironment
2022.02117.PTDC
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)
UID/Multi/04462/2019
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2019/09/30 Engineering biosensors for human cell type and state diagnosis using synthetic digital computation
MIT-EXPL/BIO/0097/2017
Universidade Nova de Lisboa, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Massachusetts Institute of Technology, United States

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/12/01 - 2018/05/31 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
MITP-TB/ECE/0013/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

University of Minnesota Twin Cities Department of Medicine, United States

Instituto de Biologia Experimental e Tecnológica, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/01/01 - 2018/03/31 CardioRegen: Integrative studies from the embryo to Scalable Multipronged Generation of hESC-derived Myocardial progenitors for heart repair
HMSP-ICT/0039/2013
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Human central nervous system in vitro models for preclinical research: new tools for studying viral vector-mediated gene delivery in 3D cell context
PTDC/EBB-BIO/119243/2010
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Institut de Génétique Moléculaire Montpellier, France
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2015/03/31 Microfluidics light-sheet microscopy for increased throughput analysis of 3D cell models and zebra-fish
EXPL/BBB-IMG/0363/2013
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Fundação Champalimaud, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity
PTDC/EBB-BIO/112786/2009
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/01 - 2013/05/31 2D fluorometry: a powerful tool to improve mammalian cell process development
PTDC/EBB-EBI/102750/2008
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/01 - 2013/02/28 BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production.
PTDC/EBB-EBI/103359/2008
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Domenici, G.; Trindade, G.; Estrada, M.F.; Cartaxo, A.L.; Alves, P.M.; André, S.; Brito, C.. "Patient-Derived Breast Cancer Tissue Cultures for Anti-Endocrine Drug Assays". 11-31. 2022.
    10.1007/978-1-0716-2513-2_2
  2. Rebelo, S.P.; Pinto, C.; Lopes, N.; Martins, T.R.; Alves, P.M.; Brito, C.. "3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment". 117-130. 2020.
    10.1007/978-1-0716-0171-6_8
  3. Pinto, C.; Estrada, M.F.; Brito, C.. "In Vitro and Ex Vivo Models – The Tumor Microenvironment in a Flask". 431-443. 2020.
    10.1007/978-3-030-34025-4_23
  4. Vidic, S.; Estrada, M.F.; Gjerde, K.; Santo, V.E.; Osswald, A.; Barbier, M.; Chong, Y.T.; et al. "PREDECT protocols for complex 2D/3D cultures". 1-20. 2019.
    10.1007/978-1-4939-8891-4_1
  5. Simão, Daniel; Arez, Francisca; Terasso, Ana P.; Pinto, Catarina; Sousa, Marcos F. Q.; Brito, Catarina; Alves, Paula M.. "Perfusion Stirred-Tank Bioreactors for 3D Differentiation of Human Neural Stem Cells". In Bioreactors in Stem Cell Biology, edited by Turksen K, 129-142. Springer New York, 2016.
    10.1007/7651_2016_333
  6. Rebelo, Sofia P.; Dehne, Eva-Maria; Brito, Catarina; Horland, Reyk; Alves, Paula M.; Marx, Uwe. "Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment". In Validation of Alternative Methods for Toxicity Testing, edited by Eskes C; Whelan M, 299-316. Springer International Publishing, 2016.
    10.1007/978-3-319-33826-2_12
  7. Rebelo, Sofia P.; Costa, Rita; Sousa, Marcos F. Q.; Brito, Catarina; Alves, Paula M.. "Establishing Liver Bioreactors for In Vitro Research". In Protocols in In Vitro Hepatocyte Research, edited by Rogiers V; Vinken M, 189-202. Springer New York, 2014.
    10.1007/978-1-4939-2074-7_13
  8. Serra, Margarida; Correia, Cláudia; Brito, Catarina; Alves, Paula M.. "Bioprocessing of Human Pluripotent Stem Cells for Cell Therapy Applications". In Stem Cells and Cell Therapy, edited by Al-Rubeai M; Naciri M, 71-95. Dordrecht, Netherlands: Springer Netherlands, 2013.
    10.1007/978-94-007-7196-3_4
Journal article
  1. Catarina Monteiro Gomes; Sebastião, Maria; Gabriela Silva; Filipa Moura; Simão, Daniel; GOMES-ALVES, Patrícia; Alves, Paula; Catarina Brito . Corresponding author: Catarina Brito. "Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV". Frontiers in Bioengineering and Biotechnology 12 (2024): 1379597. https://doi.org/10.3389/fbioe.2024.1379597.
    Open access • Published
  2. Cox, M.C.; Mendes, R.; Halwachs, K.N.; Domenici, G.; Brito, C.; Boghaert, E.R.. "Tackling the tumor microenvironment–how can complex tumor models in vitro aid oncology drug development?". Expert Opinion on Drug Discovery 18 7 (2023): 753-768. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160063655&partnerID=MN8TOARS.
    10.1080/17460441.2023.2216016
  3. Batalha, S.; Gomes, C.M.; Brito, C.. "Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade". Frontiers in Immunology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85176422043&partnerID=MN8TOARS.
    10.3389/fimmu.2023.1267621
  4. Rita Mendes; Gonçalo Graça; Fernanda Silva; Ana C. L. Guerreiro; Patrícia Gomes-Alves; Jacinta Serpa; Erwin R. Boghaert; et al. "Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer". Cancers (2022): https://doi.org/10.3390/cancers14184460.
    10.3390/cancers14184460
  5. Simão, Daniel; Gomes, Catarina M.; Alves, Paula M.; Brito, Catarina. "Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models". Biotechnology Advances 55 (2022): 107883. http://dx.doi.org/10.1016/j.biotechadv.2021.107883.
    Open access • Published • 10.1016/j.biotechadv.2021.107883
  6. Carecho, Rafael; Figueira, Inês; Terrasso, Ana Paula; Godinho-Pereira, Joana; de Oliveira Sequeira, Catarina; Pereira, Sofia Azeredo; Milenkovic, Dragan; et al. "Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease". Molecular Nutrition & Food Research (2022): 2100959. http://dx.doi.org/10.1002/mnfr.202100959.
    10.1002/mnfr.202100959
  7. Fontinha, D.; Arez, F.; Gal, I.R.; Nogueira, G.; Moita, D.; Baeurle, T.H.H.; Brito, C.; et al. "Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models". ACS Infectious Diseases 8 4 (2022): 721-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127957998&partnerID=MN8TOARS.
    Open access • Accepted • 10.1021/acsinfecdis.1c00640
  8. Silva, F.; Coelho, F.; Peixoto, A.; Pinto, P.; Martins, C.; Frombach, A.-S.; Santo, V.E.; et al. "Establishment and characterization of a novel ovarian high-grade serous carcinoma cell line—IPO43". Cancer Cell International 22 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85129230430&partnerID=MN8TOARS.
    10.1186/s12935-022-02600-3
  9. Khandelwal, A.; Arez, F.; Alves, P.M.; Badolo, L.; Brito, C.; Fischli, C.; Fontinha, D.; et al. "Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside". Malaria Journal 21 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130035533&partnerID=MN8TOARS.
    10.1186/s12936-022-04171-0
  10. da Mata, Sara; Franchi-Mendes, Teresa; Abreu, Sofia; Filipe, Bruno; Morgado, Sónia; Mesquita, Marta; Albuquerque, Cristina; et al. "Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures". Cancers 13 18 (2021): 4695. http://dx.doi.org/10.3390/cancers13184695.
    Open access • Published • 10.3390/cancers13184695
  11. Cox, Megan C.; Mendes, Rita; Silva, Fernanda; Mendes, Teresa F.; Zelaya-Lazo, Adelyn; Halwachs, Kathleen; Purkal, Julie J.; et al. "Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-97894-0.
    Open access • Published • 10.1038/s41598-021-97894-0
  12. Bordalo, Mário; Seabra, Inês J.; Silva, Andreia Bento; Terrasso, Ana Paula; Brito, Catarina; Serra, Margarida; Bronze, Maria R.; et al. "Using High-Pressure Technology to Develop Antioxidant-Rich Extracts from Bravo de Esmolfe Apple Residues". Antioxidants 10 9 (2021): 1469. http://dx.doi.org/10.3390/antiox10091469.
    Open access • Published • 10.3390/antiox10091469
  13. Franchi-Mendes, Teresa; Eduardo, Rodrigo; Domenici, Giacomo; Brito, Catarina. "3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment". Cancers 13 18 (2021): 4610. http://dx.doi.org/10.3390/cancers13184610.
    Open access • Published • 10.3390/cancers13184610
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  77. Brito, C.; Kandzia, S.; Graça, T.; Conradt, H.S.; Costa, J.. "Human fucosyltransferase IX: Specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization". Biochimie 90 9 (2008): 1279-1290. http://www.scopus.com/inward/record.url?eid=2-s2.0-47949107623&partnerID=MN8TOARS.
    10.1016/j.biochi.2008.03.002
  78. Serra, M.; Leite, S.B.; Brito, C.; Costa, J.; Carrondo, M.J.T.; Alves, P.M.. "Novel culture strategy for human stem cell proliferation and neuronal differentiation". Journal of Neuroscience Research 85 16 (2007): 3557-3566. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849057199&partnerID=MN8TOARS.
    10.1002/jnr.21451
  79. Brito, C.; Gouveia, R.; Costa, J.. "Stable expression of an active soluble recombinant form of human fucosyltransferase IX in Spodoptera frugiperda Sf9 cells". Biotechnology Letters 29 11 (2007): 1623-1630. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848917574&partnerID=MN8TOARS.
    10.1007/s10529-007-9455-x
  80. Brito, C.; Escrevente, C.; Reis, C.A.; Lee, V.M.-Y.; Trojanowski, J.Q.; Costa, J.. "Increased levels of fucosyltransferase IX and carbohydrate Lewis x adhesion determinant in human NT2N neurons". Journal of Neuroscience Research 85 6 (2007): 1260-1270. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248143888&partnerID=MN8TOARS.
    10.1002/jnr.21230
  81. Escrevente, C.; Machado, E.; Brito, C.; Reis, C.A.; Stoeck, A.; Runz, S.; Marmé, A.; Altevogt, P.; Costa, J.. "Different expression levels of a3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines". International Journal of Oncology 29 3 (2006): 557-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749360659&partnerID=MN8TOARS.
  82. Morais, V.A.; Brito, C.; Pijak, D.S.; Crystal, A.S.; Fortna, R.R.; Li, T.; Wong, P.C.; Doms, R.W.; Costa, J.. "N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53". Biochimica et Biophysica Acta - Molecular Basis of Disease 1762 9 (2006): 802-810. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748903182&partnerID=MN8TOARS.
    10.1016/j.bbadis.2006.06.018
  83. Sousa, V.L.; Brito, C.; Costa, J.. "Deletion of the cytoplasmic domain of human a3/4 fucosyltransferase III causes the shift of the enzyme to early Golgi compartments". Biochimica et Biophysica Acta - General Subjects 1675 1-3 (2004): 95-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-7944229079&partnerID=MN8TOARS.
    10.1016/j.bbagen.2004.08.015
  84. Sousa, V.L.; Brito, C.; Costa, T.; Lanoix, J.; Nilsson, T.; Costa, J.. "Importance of Cys, Gln, and Tyr from the transmembrane domain of human a3/4 fucosyltransferase III for its localization and sorting in the Golgi of baby hamster kidney cells". Journal of Biological Chemistry 278 9 (2003): 7624-7629. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037470039&partnerID=MN8TOARS.
    10.1074/jbc.M209325200
Preprint
  1. Luisa de Lemos; Pedro Antas; Inês S. Ferreira; Inês Paz Santos; Catarina M. Gomes; Catarina Brito; Miguel C. Seabra; Sandra Tenreiro. "3D human retinal organoid model for the study of early diabetic retinopathy". 2023. https://doi.org/10.1101/2023.09.04.556258.
    10.1101/2023.09.04.556258

Intellectual property

Patent
  1. Catarina Brito. 2018. "Infected Cell Cultures".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/01/27 Modelling Cell Microenvironment Dynamics in Disease 3D Cell Culture Workshop
Institute of Chemical Technology Mumbai (Mumbai, India)
2021/12 Modelling cell microenvironment dynamics in disease 3D cell culture symposium
Oxford Global (United Kingdom)
2021/11 Modelling the tumor microenvironment using 3D cell models – focus on tumor-associated macrophages BioPro - Open Academia Day
Novartis (Switzerland)
2021/10 Modelling Neuronal Microenvironmental Dynamics in disease Brain Plasticity Course
Université de Paris (Paris, France)
2021/07 Modelling neuronal microenvironment dynamics in disease and aging EIT Health Ageing PhD School
EIT, European Institute of Innovation and Technology Health (Coimbra, Portugal)
2021/06/22 Modelling Cellular Microenvironment Dynamics in 3D 9th Antibody Industrial Symposium
LabEx MAbImprove, France (Montpellier , France)
2021/05/01 3D-3 Cultures, in vitro tumor microenvironment models Annual Meeting of EFOR, French Network of Functional Studies in Model Organisms
Annual Meeting of EFOR, French Network of Functional Studies in Model Organisms (France)
2021 3D culture strategies to address cell microenvironment remodeling in disease and therapeutic response Microbiotec 21
Portuguese Society of Biotechnology; Portuguese Society of Microbiology (Lisbon )
2020/11/23 Modelling cellular microenvironment dynamics in 3D Organoids With]Out[ Borders - Online Symposium
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto (Portugal)
2020 In vitro/Ex vivo 3D Models to Address the Immune Tumor Microenvironment ImmunoOncology Summit Europe
Cambridge HealthTech Institute (London , United Kingdom)
2019/04 Modelling neuronal microenvironment dynamics in disease Syaptic Function, Dysfunction and Repair
University College London (Lisbon , Portugal)
2019/03 3D-3-culture: a tool to unveil macrophage plasticity in the tumour microenvironment ImmunoOncology Summit Europe
Cambridge HealthTech Institute (London, United Kingdom)
2018/11 Exploiting 3D cell culture to recapitulate pathological signatures of human brain microenvironment World Preclinical Congress Europe 2018
Cambridge HealthTech Institute (Lisbon )
2018/11 3D-3-culture: a tool to unveil macrophage plasticity in the tumor microenvironment World Preclinical Congress Europe 2018
Cambridge HealthTech Institute (Lisbon )
2018/10 Exploiting 3D cell culture to model cellular microenvironment in disease SLAS Advanced 3D Human Models and High-Content Analysis Conference
Society for Laboratory Automation and Screening (SLAS) (Leiden, Netherlands)
2018/06 3D cell culture strategies to model cancer microenvironment dynamics Cancer Modelling Meeting
Roche-CHUS Joint Unit, a joint initiative between Roche Farma S.A. and The Group of Translational Medical Oncology of the Health Research Institute in Santiago de Compostela (Santiago de Compostela , Spain)
2018/02 Modeling Disease Microenvironment Dynamics in Bioreactors 3D cell culture
SMi Group (London , United Kingdom)
2018 Exploiting 3D cell culture to model disease microenvironment Regenerative Medicine: organoids and model species
Aviesan, French National Alliance for Life Sciences and Health (Paris, France)
2017/11 Modeling Disease Microenvironment Dynamics in Bioreactors World Preclinical Congress Europe 2017
Cambridge HealthTech Institute (Lisbon , Portugal)
2017/07 Exploring human Stem Cells to mimic neural microenvironment Symposium Inexo: Alternative Models - In vitro, ex ovo and organism - from research to applications in pathologies and aging
French Society of Pharmacy & Latin Mediterranean Association Societies Pharmacy (Montpellier , France)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/01/01 - 2026/12/01 HepaToGeT - Immune-competent hepatic 3D cultures as preclinical tools for the development of viral vector-based gene therapies
Supervisor
Biociências Moleculares (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/10/01 - 2026/09/30 MyLeCAN – Defining the landscape of immunosuppressive myeloid lectins in breast cancer and their potential as therapeutic targets
Supervisor of Gonçalo Santos Moura Trindade
Biociências Moleculares (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/04/01 - 2025/03/31 Human stem cell-based models to study innate immunity and neuroinflammation in the central nervous system
Supervisor of Catarina Monteiro Gomes
Biociências Moleculares (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/01/01 - 2024/12/31 GLYCO-Interact - Defining triple negative breast cancer glycan signatures to target tumor-associated macrophages
Supervisor of Nuno Filipe Lavos Lopes
Biociências Moleculares (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2018 - 2024/05/07 The effect of dual HER2 blockade on anti-tumor immune cells
Supervisor of Ana Sofia Rocha Batalha
Bioengenharia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/09 - 2023/05/30 3D cell models to study the contribution of the glioma cell - microglia molecular crosstalk to the immunosuppressive microenvironment
Co-supervisor
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2018/01/01 - 2022/07/04 Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
Co-supervisor of Ana Rita Soares Mendes
Bioengenharia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2017 - 2021/12/17 The impact of the genetic risk factor BIN1 to Alzheimer’s disease development
Co-supervisor of Catarina Benavente Perdigão
Bioengenharia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017 - 2021/07/22 Three-dimensional culture approaches to advance representation of the tumor microenvironment in preclinical and translational research
Supervisor of Maria Teresa Franchi Mendes
Bioengenharia (PhD)
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/09 - 2021/06/17 A 3D hepatic model to address immune-mediated drug hepatotoxicity
Supervisor of Jhenifer de Farias Oliveira
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2019/09 - 2021/05/12 Pre-Clinical Evaluation of Targeted Therapies Using 3D Cell Models of Breast Cancer
Co-supervisor of Gonçalo Santos Moura Trindade
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2015 - 2020/10/01 Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies
Supervisor of Ana Luísa Pécurto Cartaxo
Bioengenharia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09 - 2020/01 Exploring induced pluripotent stem cell-derived 3D neural cultures to model Mucopolysaccharidosis type VII
Supervisor of Beatriz Alexandra Carones Painho
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09 - 2019/10 Exploring Tumor-Macrophage Interaction in Anaplastic Thyroid Cancer
Co-supervisor of Rodrigo Manuel Ferreira Eduardo
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2019/05 Development of cell models for translation cancer research
Supervisor of Sofia de Almeida Santos de Castro e Abreu
Bioengenharia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09 - 2019/01 Patient-derived cultures for cancer modelling
Co-supervisor of Marta Carolina Jesus Teixeira
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09 - 2018/11 Depicting the tumor-associated macrophage phenotype employing 3D breast cancer cell models
Supervisor of Nuno Filipe Lavos Lopes
Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/08 - 2018/11 Identificação de Glicanos no estudo do Microambiente Tumoral
Co-supervisor of Ana Margarida Coelho Marques
Bioquímica (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2018/11 Novel cell models to study breast tumour microenvironment and disease progression
Supervisor of Marta Maria Vieira Matutino Falcão Estrada
Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - 2018/07 Targeting Cancer Vulnerabilities: From molecular targets to antitumor immunity
Co-supervisor of Ana Catarina Pereira Pinto
Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2018/04 Novel human iPSC-derived neurological disease models
Supervisor of Ana Paula Barreto Terrasso
Ciências da Engenharia e Tecnologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2017/12 Deciphering the potential of blackberry polyphenols for Parkinson Disease: digestion, bloof brain barrier transposition and neuroprotective effect
Co-supervisor of Inês Margarida Lourenço Figueira
Bioquímica (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/09 - 2016/10 Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents
Co-supervisor of Diana Oliveira da Silva
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2015/12 Development of human central nervous system 3D in vitro models for preclinical research
Supervisor of Daniel Filipe Mestre Simão
Bioengenharia (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/09 - 2015/10 Novel in vitro human 3D neural model derived from induced pluripotent stem cells
Supervisor of Francisca Maria de Andrade Terras Arez
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/07 - 2015/06 Development of 3D in vitro models for prediction of hepatic metabolism and toxicity
Co-supervisor of Sofia Raquel Paulo Rebelo
Bioengenharia (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/09 - 2014/10 Development of 3D cancer cell models for pre-clinical research: evaluation of the tumour microenvironment in 3D stirred-systems
Supervisor of Susana Caçador Veloso
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/09 - 2013/11 Evaluation of Chemotherapeutic Potencial of Natural Extracts Using 3D Models of Colon Cancer
Co-supervisor of Inês Alexandra Marreiros da Silva
Biotecnologia (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/09 - 2012/11 Novel human Central Nervous System 3D in vitro models: useful tools for evaluation of viral vector-mediated gene deliver
Supervisor of Ana Catarina Pereira Pinto
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/07 - 2011/11 Development of novel human cellular models for neurotoxicity studies
Supervisor of Ana Paula Barreto Terrasso
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2015 - Current ESACT Drug Discovery Course (2014)
Workshop (Co-organisor)
European Society for Animal Cell Technology (ESACT), Germany
2014/12/15 - 2015/11/15 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2015/10/15 - 2015/10/16)
Conference (Member of the Organising Committee)
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2020/02/17 Molecular mechanisms involved in peritoneal dissemination of ovarian cancer: emphasis on the role of mesothelin
(Thesis) Main arguer
Ricardo Jorge Bouça-Nova Coelho (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2019/12/02 Study of 3D tumor spheroids for biomedical applications
(Thesis) Main arguer
Elisabete Cristina da Rocha Costa (PhD)
Universidade da Beira Interior, Portugal
2019/09/06 Bioengineering 3D models to deconstruct the role of extracellular matrix microenvironment in gastric cancer
(Thesis) Main arguer
Bianca do Nascimento Lourenço (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/06/17 Intercellular relationships in the tumor microenvironment: implications for cancer pathophysiology
(Thesis) Main arguer
Ana Isabel Ferreira de Oliveira (PhD)
Universidade do Minho, Portugal
2018/06/26 Colorectal tumor microenvironment: unravelling the interplay between macrophages and the extracellular matrix
(Thesis) Main arguer
Marta Laranjeiro Pinto (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/05/12 Development of a new 2D-bioreactor based on openmicrofluidic concept for high-throughput analysis in tissue engineering and biotechnological applications
(Thesis) Main arguer
Nuno Miguel Ribeiro de Oliveira (PhD)
Universidade do Minho, Portugal
2017 Molecular mechanisms underlying the action of histone deacetylases inhibitors (HDACIs) in ovarian cancer
(Thesis) Arguer
FERNANDA MARIA GONÇALVES DA SILVA (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 Novel Cryopreservation Strategies for Cell-therapies and Pre-clinical Research
(Thesis) Arguer
Rita Maria Martins de Sousa Maia Malpique (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Association member

Society Organization name Role
2020/12 - Current European Federation of Biotechnology (EFB) Member of the Division of Biopharmaceutical and Medical Biotechnology
2013 - Current Portuguese Association for Cancer Research
2012 - Current European Association for Cancer Research (EACR)
2008 - Current Portuguese Society for Stem Cells and Cell Therapies Coordinator of the "Science and Technology of Stem Cells" Section
2008 - Current European Society for Animal Cell Technology
1999 - Current Portuguese Society of Biochemistry

Committee member

Activity description
Role
Institution / Organization
2018 - Current Management Board
Member
iNOVA4Health, Portugal
2013 - Current Executive Committee of the PhD Program in Molecular Biosciences (MolBioS)
Member
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - Current Coordinator of the Biopharmaceutical Technology Profile of the PhD program in Molecular Biosciences (MolBioS)
Coordinator
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2018 Scientific Board of the Analytical Services Unit
President / Vice-president
Instituto de Biologia Experimental e Tecnológica, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2013 - Current Tools for Discovery and Preclinical Research Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2023 - 2023 Call for Technology Convervenge for Enabling technologies
Member
Norges forskningsråd, Norway Norges forskningsråd
2020 - 2022 Referee and Member of the Evaluation Panel, Oncology
Member
Norges forskningsråd, Norway Norges forskningsråd
2019 - 2020 Plan Cancer: Novel Experimental Models for Cancer Research: optimization of 3R Alliance nationale pour les sciences de la vie et de la santé, France

INSERM, France
2017 - 2017 Joint trans-national call for multinational research projects for pathway analysis (Pathways 2017) EU Joint Programme Neurodegenerative Disease Research, Germany

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers in Molecular Neuroscience (1662-5099) Frontiers
2019 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2019 - Current Frontiers in Toxicology (2673-3080) Frontiers Media SA
Distinctions

Award

2015 Scientific Merit Award from Santander Totta/ New University of Lisbon
Banco Santander Portugal, Portugal