Ana CATARINA Maurício BRITO Ataíde Montes (7C16-D64C-9CF8)

Curriculum Vitae

Ana CATARINA Maurício BRITO Ataíde Montes

Catarina Brito is the Principal Investigator (tenure) of ITQB NOVA. She has been the Head of the Advanced Cell Models Lab of iBET and ITQB NOVA since 2014; currently leading a team of 15 researchers: 6 post-docs, 5 PhD students (individual grants), 2 MSc research fellows, and 2 MSc students. C Brito’s research focuses on microenvironment-driven modulation of disease progression and targeted therapy responses, through the development and interrogation of in vitro and ex vivo models of the disease microenvironment (emphasis on immunosuppressive breast carcinomas and high-grade gliomas; and other CNS pathologies). Currently, her team investigates myeloid cell-driven inflammatory and immunosuppressive microenvironments, along 2 central research lines: 1. Neuron-glia crosstalk in neuroinflammation and early tissue response to viral vectors; 2. Macrophage-tumor cell crosstalk in immunosuppression and resistance to immunomodulatory therapies. The group has pioneered cell-based strategies to tackle challenges in the imminent areas of cancer immunotherapies and viral vector-based gene therapies. Background: PhD in Biochemistry & Cell Biology (2007), by ITQB-NOVA (PT) and Degree in Biochemistry (2001, University of Lisbon). PhD training - glycobiology and intracellular trafficking in human cells, Glycobiology Lab (ITQB-NOVA) and Membrane Traffic in Neuronal & Epithelial Morphogenesis Lab (Institut Jacques Monod, France). Postdoctoral training in stem cell biotechnology and cell-based assay development (iBET, PT). Funding: PI/co-PI of 18 projects + team member of 31 projects, funded by FCT (5+12), EC and Innovative Medicines Initiative (EC & EFPIA) (2+9); iNOVA4Health (PT) and iBET internal calls (7+10), and the Pharmaceutical Industry (4 as PI). Productivity: 83 articles in peer-reviewed journals, 26 as senior/corresponding author, and 8 book chapters; h-index=28 (Scopus), over 3500 citations. Invited lectures in conference cycles and international courses, academic (22) and industrial (7); Invited lecturer in international conferences (49), of over 100 oral communications and 150 posters as presenting/corresponding. Supervision/co-supervision: PhD theses- 16 (12 concluded+1 submitted); MSc theses: 15 (14 concluded). Postdoctoral fellows & senior researchers: 10. Teaching & advanced training: Member of the Executive Committee of MolBioS: PhD program in Molecular Biosciences (coordinated by ITQB NOVA); Coordinator of the Biopharmaceutical Technology Profile, 2013-2022; Coordinator of the Curricular Unit, Tools for Discovery and Preclinical Research, since 2013; Co-coordinator of the ESACT Drug Discovery Course, Costa Brava, Spain, 2015 – 2022; Regular lecturer in MSc and PhD programs in Biomedicine and Bioengineering. Other duties: Chair Scientific Board, Analytical Services Unit (iBET, 2015-2018); Co-administrator of the Science & Services Section of the Animal Technology Unit, iBET (2012-2021); Management Board of the iNOVA4Health Research Unit: member (2018-23); ITQB NOVA representative (since 2024); Coordinator of the Science and Technology of Stem Cells Section of the Portuguese Society for Stem Cells and Cell Therapies (2018-2021); Member of the Division of Biopharmaceutical and Medical Biotechnology of EFB (European Federation of Biotechnology) Evaluation Committees: EU Joint Programme Neurodegenerative Disease Research (JPND, 2017, 2018, 2024); Novel Experimental Models for Cancer Research: optimization of 3R (2019, 2002), AVIESAN, Inserm; Research Council of Norway (since 2020); co-coordinator of the Biochemistry & Experimental Biology panel, FCT call PhD fellowships (2022). Regular expert reviewer: RCUK, Breast Cancer Now, UK Research & Innovation (UK); FWO (Belgium); STW (Netherlands); ANR, Inserm (France). Editorial Board Member: Scientific Reports; Invited Editor: Scientific Reports; Frontiers in Immunology; Review Editor in several journals.

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Identification

Personal identification

Full name: Ana CATARINA Maurício BRITO Ataíde Montes
Gender: Female

Citation names

Catarina Brito

Author identifiers

Ciência ID: 7C16-D64C-9CF8
ORCID iD: 0000-0002-8926-279X
Google Scholar ID: https://scholar.google.com/citations?user=szZhQl4AAAAJ&hl=en
Researcher Id: A-2389-2009
Scopus Author Id: 7007023897

Addresses

iBET. Apartado 12, 2780-901 O, Oeiras, Oeiras, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language	Speaking	Reading	Writing	Listening
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)
Spanish; Castilian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2018 Concluded	Bioengenharia (Doutoramento) Major in Sem especialidade Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal "Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer" (THESIS/DISSERTATION)
2017 Ongoing	Bioengenharia (Doutoramento) Major in Especialidade: Bioengenharia - Terapias Celulares e Medicina Regenerativa Universidade de Lisboa Instituto Superior Técnico, Portugal "The impact of the genetic risk factor Bin1 to Alzheimer’s disease development" (THESIS/DISSERTATION)
2007/10/19 Concluded	Bioquímica (Doutoramento) Major in Especialidade: Bioquímica Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal "Fucosyltransferase IX: Characterization and Biological Role" (THESIS/DISSERTATION)	approved by unanimity
2001/10/01 Concluded	Bioquímica (Licenciatura) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal "Importance of the transmembrane domain of human fucosyltransferase III for its Golgi localization and in vivo activity (20/20)" (THESIS/DISSERTATION)	16/20

Affiliation

Science

	Category Host institution	Employer
2020/07/01 - Current	Principal Investigator (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal
	Instituto de Biologia Experimental e Tecnológica, Portugal
2018/09/01 - 2020/06/30	Contracted Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Instituto de Biologia Experimental e Tecnológica, Portugal
2014/07/01 - 2018/08/31	Contracted Researcher (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

2009/07/01 - 2014/06/30	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Instituto de Biologia Experimental e Tecnológica, Portugal
2007/11/01 - 2009/06/30	Postdoc (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

2001 - 2003	Research Assistant (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2000 - 2001	Research Trainee (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Others

	Category Host institution	Employer
2013/09/01 - 2013/10/31	Visiting Researcher	Harvard Medical School, United States

2003 - 2007/10	PhD student	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2006 - 2006	Visiting PhD student	Institut Jacques Monod, France

Projects

Grant

	Designation	Funders
2020/10/01 - 2025/10/31	Accelerating Research and Innovation for Advanced Therapies (ARDAT) 945473 945473 Principal investigator	Innovative Medicines Initiative (IMI) Ongoing
2020/01/01 - 2024/12/31	Neurospheroids to model pathological neuroinflammation 10.54499/UIDB/04462/2020 Principal investigator iNOVA4Health, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/07/01 - 2024/12/01	Depicting the tumour associated macrophage phenotype employing 3D breast cancer cell models 10.54499/UIDP/04462/2020 Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2021/11/01 - 2024/10/30	Glyco-TAM: Cracking glycan-lectin interactions to target immunosuppressive macrophages in triple-negative breast cancer PTDC/BTM-ORG/0971/2020 Principal investigator iNOVA4Health, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - 2024	The effect of dual HER2 blockade on anti-tumor immune cells 10.54499/UIDB/04462/2020 Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal	iNOVA4Health Ongoing
2018/01/01 - 2021/12/31	Patient-derived ex vivo ovarian cancer models to explore tumour microenvironment driven drug resistance in ovarian cancer -- Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal	AbbVie Inc Concluded
2018/10 - 2021/09	AstroReact - Unravelling the role of astrocyte-induced neural microenvironment remodelling in traumatic brain injury pathobiology PTDC/BTM-ORG/29580/2017 Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal Institut de Ciències Fotòniques, Spain	Fundação para a Ciência e a Tecnologia
2017 - 2020	Do genetic variants in CD2AP increase the risk of developing Alzheimer’s disease? 10.54499/UIDB/04462/2020 Collaborator Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	iNOVA4Health Ongoing
2017 - 2019	Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs 10.54499/UIDP/04462/2020 Collaborator Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/09 - 2017/08	CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications 137185 Provided by PTCRIS: 137185 Researcher	Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2016	PREDECT - New Models for preclinical evaluation of drug efficacy in common solid tumors 115188 Principal investigator Instituto de Biologia Experimental e Tecnológica, Portugal	Innovative Medicines Initiative Concluded
2013/07 - 2015/12	Combining siRNA and AAV therapy approaches to target human basal-like breast cancer: from vector development to anti-tumor efficacy evaluation. grant.Provided by PTCRIS: 126222 126222 Provided by PTCRIS: 126222 Researcher	Stichting Weten Fundação para a Ciência e a Tecnologia, I.P.
2012/02 - 2015/07	Smart particles for drug delivery to the colon and to the liver grant.Provided by PTCRIS: 119631 Provided by PTCRIS: 119631 119631 Researcher	Stichting Weten Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03	Microfluidics light-sheet microscopy for increased throughput analysis of 3D cell models and zebra-fish grant.Provided by PTCRIS: 133385 Provided by PTCRIS: 133385 133385 Researcher	Stichting Weten Fundação para a Ciência e a Tecnologia, I.P.
2012/03 - 2015/02	Human central nervous system in vitro models for preclinical research: new tools for studying viral vector-mediated gene delivery in 3D cell context 119243 Provided by PTCRIS: 119243 grant.Provided by PTCRIS: 119243 Principal investigator	Fundação para a Ciência e a Tecnologia, I.P. Stichting Weten
2011/03 - 2014/08	3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity grant.Provided by PTCRIS: 112786 112786 Provided by PTCRIS: 112786 Principal investigator	Stichting Weten Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2013/05	2D fluorometry: a powerful tool to improve mammalian cell process development 102750 Provided by PTCRIS: 102750 grant.Provided by PTCRIS: 102750 Post-doc	Fundação para a Ciência e a Tecnologia, I.P. Stichting Weten
2010/03 - 2013/02	BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production. Provided by PTCRIS: 103359 103359 grant.Provided by PTCRIS: 103359 Post-doc	Fundação para a Ciência e a Tecnologia, I.P.
2009 - 2012	Hyperlab: High Yield and Performance Stem Cell Lab 223011 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV, Germany	European Commission Seventh Framework Programme for Research and Technological Development Concluded
2008 - 2012	BrainCAV: Nonhuman adenovirus vectors for gene delivery to the Brain HEALTH-F5-2008-222992 Researcher Instituto de Biologia Experimental e Tecnológica, Portugal Institut de Génétique Moléculaire Montpellier, France Cancer Research UK, United Kingdom	European Commission Sixth Framework Programme Concluded
2009/01 - 2011/12	Integrated strategy for expansion, neuronal differentiation and cryopreservation of human embryonic stem cells 72755 Provided by PTCRIS: 72755 grant.Provided by PTCRIS: 72755 Post-doc	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2007/11/01 - 2009/06/30	NEURONAL DIFFERENTIATION OF THE HUMAN EMBRYONAL CARCINOMA STEM CELL LINE NTERA2/CL.D1 IN NANOSTRUCTURED SURFACES SFRH/BPD/34622/2007	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2009	CellPROM - Cell Programming by Nanoscaled Devices NMP4-CT-2004-500039 Post-doc Instituto de Biologia Experimental e Tecnológica, Portugal	European Commission Sixth Framework Programme Concluded
2004 - 2007	STREP - Signaling and Membrane Trafficking in Transformation and Differentiation LSHG-CT-2004-503228 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Institut Jacques Monod, France	European Commission Sixth Framework Programme Concluded
2002/10/01 - 2006/09/30	IMPORTANCE OF PROTEIN-PROTEIN INTERACTIONS FOR GOLGI RETENTION OF GLYCOSYLTRANSFERASES SFRH/BD/9139/2002	Fundação para a Ciência e a Tecnologia Concluded
2000 - 2001	Glicosilação das mucinas na mucosa gástrica normal, carcinoma gástrico e linhas celulares de carcinoma gástrico: papel da glicosilação e das apomucinas PRAXIS/SAU/14111/1998 Research Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 10.54499/LA/P/0087/2020 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/03/01 - 2024/08/31	Deciphering immunosuppressive events in Diffuse Midline Glioma (DMG) employing a 3D cell model of the tumor microenvironment 2022.02117.PTDC 10.54499/2022.02117.PTDC Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB) UID/Multi/04462/2019 Instituto de Biologia Experimental e Tecnológica, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07/01 - 2019/09/30	Engineering biosensors for human cell type and state diagnosis using synthetic digital computation MIT-EXPL/BIO/0097/2017 Universidade Nova de Lisboa, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal Massachusetts Institute of Technology, United States Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/12/01 - 2018/05/31	CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications MITP-TB/ECE/0013/2013 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal University of Minnesota Twin Cities Department of Medicine, United States Instituto de Biologia Experimental e Tecnológica, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/01/01 - 2018/03/31	CardioRegen: Integrative studies from the embryo to Scalable Multipronged Generation of hESC-derived Myocardial progenitors for heart repair HMSP-ICT/0039/2013 Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/03/01 - 2015/08/31	Human central nervous system in vitro models for preclinical research: new tools for studying viral vector-mediated gene delivery in 3D cell context PTDC/EBB-BIO/119243/2010 Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Institut de Génétique Moléculaire Montpellier, France	Fundação para a Ciência e a Tecnologia Concluded
2014/04/01 - 2015/03/31	Microfluidics light-sheet microscopy for increased throughput analysis of 3D cell models and zebra-fish EXPL/BBB-IMG/0363/2013 Fundação Calouste Gulbenkian, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/03/01 - 2014/08/31	3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity PTDC/EBB-BIO/112786/2009 Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/03/01 - 2013/05/31	2D fluorometry: a powerful tool to improve mammalian cell process development PTDC/EBB-EBI/102750/2008 Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/03/01 - 2013/02/28	BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production. PTDC/EBB-EBI/103359/2008 Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 4 - 2011-2012 PEst-OE/EQB/LA0004/2011 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Domenici, G.; Trindade, G.; Estrada, M.F.; Cartaxo, A.L.; Alves, P.M.; André, S.; Brito, C.. "Patient-Derived Breast Cancer Tissue Cultures for Anti-Endocrine Drug Assays". 11-31. 2022. 10.1007/978-1-0716-2513-2_2 Rebelo, S.P.; Pinto, C.; Lopes, N.; Martins, T.R.; Alves, P.M.; Brito, C.. "3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment". 117-130. 2020. 10.1007/978-1-0716-0171-6_8 Pinto, C.; Estrada, M.F.; Brito, C.. "In Vitro and Ex Vivo Models – The Tumor Microenvironment in a Flask". 431-443. 2020. 10.1007/978-3-030-34025-4_23 Vidic, S.; Estrada, M.F.; Gjerde, K.; Santo, V.E.; Osswald, A.; Barbier, M.; Chong, Y.T.; et al. "PREDECT protocols for complex 2D/3D cultures". 1-20. 2019. 10.1007/978-1-4939-8891-4_1 Simão, Daniel; Arez, Francisca; Terasso, Ana P.; Pinto, Catarina; Sousa, Marcos F. Q.; Brito, Catarina; Alves, Paula M.. "Perfusion Stirred-Tank Bioreactors for 3D Differentiation of Human Neural Stem Cells". In Bioreactors in Stem Cell Biology, edited by Turksen K, 129-142. Springer New York, 2016. 10.1007/7651_2016_333 Rebelo, Sofia P.; Dehne, Eva-Maria; Brito, Catarina; Horland, Reyk; Alves, Paula M.; Marx, Uwe. "Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment". In Validation of Alternative Methods for Toxicity Testing, edited by Eskes C; Whelan M, 299-316. Springer International Publishing, 2016. 10.1007/978-3-319-33826-2_12 Rebelo, Sofia P.; Costa, Rita; Sousa, Marcos F. Q.; Brito, Catarina; Alves, Paula M.. "Establishing Liver Bioreactors for In Vitro Research". In Protocols in In Vitro Hepatocyte Research, edited by Rogiers V; Vinken M, 189-202. Springer New York, 2014. 10.1007/978-1-4939-2074-7_13 Serra, Margarida; Correia, Cláudia; Brito, Catarina; Alves, Paula M.. "Bioprocessing of Human Pluripotent Stem Cells for Cell Therapy Applications". In Stem Cells and Cell Therapy, edited by Al-Rubeai M; Naciri M, 71-95. Dordrecht, Netherlands: Springer Netherlands, 2013. 10.1007/978-94-007-7196-3_4
Journal article	Catarina Monteiro Gomes; Sebastião, Maria; Gabriela Silva; Filipa Moura; Simão, Daniel; GOMES-ALVES, Patrícia; Alves, Paula; Catarina Brito . Corresponding author: Catarina Brito. "Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV". Frontiers in Bioengineering and Biotechnology 12 (2024): 1379597. https://doi.org/10.3389/fbioe.2024.1379597. Open access • Published Cox, M.C.; Mendes, R.; Halwachs, K.N.; Domenici, G.; Brito, C.; Boghaert, E.R.. "Tackling the tumor microenvironment–how can complex tumor models in vitro aid oncology drug development?". Expert Opinion on Drug Discovery 18 7 (2023): 753-768. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160063655&partnerID=MN8TOARS. 10.1080/17460441.2023.2216016 Batalha, S.; Gomes, C.M.; Brito, C.. "Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade". Frontiers in Immunology 14 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85176422043&partnerID=MN8TOARS. 10.3389/fimmu.2023.1267621 Rita Mendes; Gonçalo Graça; Fernanda Silva; Ana C. L. Guerreiro; Patrícia Gomes-Alves; Jacinta Serpa; Erwin R. Boghaert; et al. "Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer". Cancers (2022): https://doi.org/10.3390/cancers14184460. 10.3390/cancers14184460 Simão, Daniel; Gomes, Catarina M.; Alves, Paula M.; Brito, Catarina. "Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models". Biotechnology Advances 55 (2022): 107883. http://dx.doi.org/10.1016/j.biotechadv.2021.107883. Open access • Published • 10.1016/j.biotechadv.2021.107883 Carecho, Rafael; Figueira, Inês; Terrasso, Ana Paula; Godinho-Pereira, Joana; de Oliveira Sequeira, Catarina; Pereira, Sofia Azeredo; Milenkovic, Dragan; et al. "Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease". Molecular Nutrition & Food Research (2022): 2100959. http://dx.doi.org/10.1002/mnfr.202100959. 10.1002/mnfr.202100959 Fontinha, D.; Arez, F.; Gal, I.R.; Nogueira, G.; Moita, D.; Baeurle, T.H.H.; Brito, C.; et al. "Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models". ACS Infectious Diseases 8 4 (2022): 721-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127957998&partnerID=MN8TOARS. Open access • Accepted • 10.1021/acsinfecdis.1c00640 Silva, F.; Coelho, F.; Peixoto, A.; Pinto, P.; Martins, C.; Frombach, A.-S.; Santo, V.E.; et al. "Establishment and characterization of a novel ovarian high-grade serous carcinoma cell line—IPO43". Cancer Cell International 22 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85129230430&partnerID=MN8TOARS. 10.1186/s12935-022-02600-3 Khandelwal, A.; Arez, F.; Alves, P.M.; Badolo, L.; Brito, C.; Fischli, C.; Fontinha, D.; et al. "Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside". Malaria Journal 21 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130035533&partnerID=MN8TOARS. 10.1186/s12936-022-04171-0 da Mata, Sara; Franchi-Mendes, Teresa; Abreu, Sofia; Filipe, Bruno; Morgado, Sónia; Mesquita, Marta; Albuquerque, Cristina; et al. "Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures". Cancers 13 18 (2021): 4695. http://dx.doi.org/10.3390/cancers13184695. Open access • Published • 10.3390/cancers13184695 Cox, Megan C.; Mendes, Rita; Silva, Fernanda; Mendes, Teresa F.; Zelaya-Lazo, Adelyn; Halwachs, Kathleen; Purkal, Julie J.; et al. "Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-97894-0. Open access • Published • 10.1038/s41598-021-97894-0 Bordalo, Mário; Seabra, Inês J.; Silva, Andreia Bento; Terrasso, Ana Paula; Brito, Catarina; Serra, Margarida; Bronze, Maria R.; et al. "Using High-Pressure Technology to Develop Antioxidant-Rich Extracts from Bravo de Esmolfe Apple Residues". Antioxidants 10 9 (2021): 1469. http://dx.doi.org/10.3390/antiox10091469. Open access • Published • 10.3390/antiox10091469 Franchi-Mendes, Teresa; Eduardo, Rodrigo; Domenici, Giacomo; Brito, Catarina. "3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment". Cancers 13 18 (2021): 4610. http://dx.doi.org/10.3390/cancers13184610. Open access • Published • 10.3390/cancers13184610 Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; et al. 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"Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing". Hepatology 55 4 (2012): 1227-1236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859119473&partnerID=MN8TOARS. 10.1002/hep.24760 Brito, C.; Simão, D.; Costa, I.; Malpique, R.; Pereira, C.I.; Fernandes, P.; Serra, M.; et al. "Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells". Methods 56 3 (2012): 452-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860470339&partnerID=MN8TOARS. 10.1016/j.ymeth.2012.03.005 Serra, M.; Correia, C.; Malpique, R.; Brito, C.; Jensen, J.; Bjorquist, P.; Carrondo, M.J.T.; Alves, P.M.. "Microencapsulation technology: A powerful tool for integrating expansion and cryopreservation of human embryonic stem cells". 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"Integrating human stem cell expansion and neuronal differentiation in bioreactors". BMC Biotechnology 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70350726541&partnerID=MN8TOARS. 10.1186/1472-6750-9-82 Brito, C.; Danglot, L.; Galli, T.; Costa, J.. "Subcellular localization of the carbohydrate Lewisx adhesion structure in hippocampus cell cultures". Brain Research 1287 (2009): 39-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149162559&partnerID=MN8TOARS. 10.1016/j.brainres.2009.06.075 Serra, M.; Brito, C.; Leite, S.B.; Gorjup, E.; von Briesen, H.; Carrondo, M.J.T.; Alves, P.M.. "Stirred bioreactors for the expansion of adult pancreatic stem cells". Annals of Anatomy 191 1 (2009): 104-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149314043&partnerID=MN8TOARS. 10.1016/j.aanat.2008.09.005 Brito, C.; Kandzia, S.; Graça, T.; Conradt, H.S.; Costa, J.. "Human fucosyltransferase IX: Specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization". Biochimie 90 9 (2008): 1279-1290. http://www.scopus.com/inward/record.url?eid=2-s2.0-47949107623&partnerID=MN8TOARS. 10.1016/j.biochi.2008.03.002 Serra, M.; Leite, S.B.; Brito, C.; Costa, J.; Carrondo, M.J.T.; Alves, P.M.. "Novel culture strategy for human stem cell proliferation and neuronal differentiation". Journal of Neuroscience Research 85 16 (2007): 3557-3566. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849057199&partnerID=MN8TOARS. 10.1002/jnr.21451 Brito, C.; Gouveia, R.; Costa, J.. "Stable expression of an active soluble recombinant form of human fucosyltransferase IX in Spodoptera frugiperda Sf9 cells". Biotechnology Letters 29 11 (2007): 1623-1630. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848917574&partnerID=MN8TOARS. 10.1007/s10529-007-9455-x Brito, C.; Escrevente, C.; Reis, C.A.; Lee, V.M.-Y.; Trojanowski, J.Q.; Costa, J.. "Increased levels of fucosyltransferase IX and carbohydrate Lewis x adhesion determinant in human NT2N neurons". Journal of Neuroscience Research 85 6 (2007): 1260-1270. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248143888&partnerID=MN8TOARS. 10.1002/jnr.21230 Escrevente, C.; Machado, E.; Brito, C.; Reis, C.A.; Stoeck, A.; Runz, S.; Marmé, A.; Altevogt, P.; Costa, J.. "Different expression levels of a3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines". International Journal of Oncology 29 3 (2006): 557-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749360659&partnerID=MN8TOARS. Morais, V.A.; Brito, C.; Pijak, D.S.; Crystal, A.S.; Fortna, R.R.; Li, T.; Wong, P.C.; Doms, R.W.; Costa, J.. "N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53". Biochimica et Biophysica Acta - Molecular Basis of Disease 1762 9 (2006): 802-810. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748903182&partnerID=MN8TOARS. 10.1016/j.bbadis.2006.06.018 Sousa, V.L.; Brito, C.; Costa, J.. "Deletion of the cytoplasmic domain of human a3/4 fucosyltransferase III causes the shift of the enzyme to early Golgi compartments". Biochimica et Biophysica Acta - General Subjects 1675 1-3 (2004): 95-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-7944229079&partnerID=MN8TOARS. 10.1016/j.bbagen.2004.08.015 Sousa, V.L.; Brito, C.; Costa, T.; Lanoix, J.; Nilsson, T.; Costa, J.. "Importance of Cys, Gln, and Tyr from the transmembrane domain of human a3/4 fucosyltransferase III for its localization and sorting in the Golgi of baby hamster kidney cells". Journal of Biological Chemistry 278 9 (2003): 7624-7629. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037470039&partnerID=MN8TOARS. 10.1074/jbc.M209325200
Preprint	Luisa de Lemos; Pedro Antas; Inês S. Ferreira; Inês Paz Santos; Catarina M. Gomes; Catarina Brito; Miguel C. Seabra; Sandra Tenreiro. "3D human retinal organoid model for the study of early diabetic retinopathy". 2023. https://doi.org/10.1101/2023.09.04.556258. 10.1101/2023.09.04.556258

Intellectual property

Patent

Catarina Brito. 2018. "Infected Cell Cultures".

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/01/27	Modelling Cell Microenvironment Dynamics in Disease	3D Cell Culture Workshop Institute of Chemical Technology Mumbai (Mumbai, India)
2021/12	Modelling cell microenvironment dynamics in disease	3D cell culture symposium Oxford Global (United Kingdom)
2021/11	Modelling the tumor microenvironment using 3D cell models – focus on tumor-associated macrophages	BioPro - Open Academia Day Novartis (Switzerland)
2021/10	Modelling Neuronal Microenvironmental Dynamics in disease	Brain Plasticity Course Université de Paris (Paris, France)
2021/07	Modelling neuronal microenvironment dynamics in disease and aging	EIT Health Ageing PhD School EIT, European Institute of Innovation and Technology Health (Coimbra, Portugal)
2021/06/22	Modelling Cellular Microenvironment Dynamics in 3D	9th Antibody Industrial Symposium LabEx MAbImprove, France (Montpellier , France)
2021/05/01	3D-3 Cultures, in vitro tumor microenvironment models	Annual Meeting of EFOR, French Network of Functional Studies in Model Organisms Annual Meeting of EFOR, French Network of Functional Studies in Model Organisms (France)
2021	3D culture strategies to address cell microenvironment remodeling in disease and therapeutic response	Microbiotec 21 Portuguese Society of Biotechnology; Portuguese Society of Microbiology (Lisbon )
2020/11/23	Modelling cellular microenvironment dynamics in 3D	Organoids With]Out[ Borders - Online Symposium Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto (Portugal)
2020	In vitro/Ex vivo 3D Models to Address the Immune Tumor Microenvironment	ImmunoOncology Summit Europe Cambridge HealthTech Institute (London , United Kingdom)
2019/04	Modelling neuronal microenvironment dynamics in disease	Syaptic Function, Dysfunction and Repair University College London (Lisbon , Portugal)
2019/03	3D-3-culture: a tool to unveil macrophage plasticity in the tumour microenvironment	ImmunoOncology Summit Europe Cambridge HealthTech Institute (London, United Kingdom)
2018/11	Exploiting 3D cell culture to recapitulate pathological signatures of human brain microenvironment	World Preclinical Congress Europe 2018 Cambridge HealthTech Institute (Lisbon )
2018/11	3D-3-culture: a tool to unveil macrophage plasticity in the tumor microenvironment	World Preclinical Congress Europe 2018 Cambridge HealthTech Institute (Lisbon )
2018/10	Exploiting 3D cell culture to model cellular microenvironment in disease	SLAS Advanced 3D Human Models and High-Content Analysis Conference Society for Laboratory Automation and Screening (SLAS) (Leiden, Netherlands)
2018/06	3D cell culture strategies to model cancer microenvironment dynamics	Cancer Modelling Meeting Roche-CHUS Joint Unit, a joint initiative between Roche Farma S.A. and The Group of Translational Medical Oncology of the Health Research Institute in Santiago de Compostela (Santiago de Compostela , Spain)
2018/02	Modeling Disease Microenvironment Dynamics in Bioreactors	3D cell culture SMi Group (London , United Kingdom)
2018	Exploiting 3D cell culture to model disease microenvironment	Regenerative Medicine: organoids and model species Aviesan, French National Alliance for Life Sciences and Health (Paris, France)
2017/11	Modeling Disease Microenvironment Dynamics in Bioreactors	World Preclinical Congress Europe 2017 Cambridge HealthTech Institute (Lisbon , Portugal)
2017/07	Exploring human Stem Cells to mimic neural microenvironment	Symposium Inexo: Alternative Models - In vitro, ex ovo and organism - from research to applications in pathologies and aging French Society of Pharmacy & Latin Mediterranean Association Societies Pharmacy (Montpellier , France)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/01/01 - 2026/12/01	HepaToGeT - Immune-competent hepatic 3D cultures as preclinical tools for the development of viral vector-based gene therapies Supervisor	Biociências Moleculares (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/10/01 - 2026/09/30	MyLeCAN – Defining the landscape of immunosuppressive myeloid lectins in breast cancer and their potential as therapeutic targets Supervisor of Gonçalo Santos Moura Trindade	Biociências Moleculares (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/04/01 - 2025/03/31	Human stem cell-based models to study innate immunity and neuroinflammation in the central nervous system Supervisor of Catarina Monteiro Gomes	Biociências Moleculares (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/01/01 - 2024/12/31	GLYCO-Interact - Defining triple negative breast cancer glycan signatures to target tumor-associated macrophages Supervisor of Nuno Filipe Lavos Lopes	Biociências Moleculares (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2018 - 2024/05/07	The effect of dual HER2 blockade on anti-tumor immune cells Supervisor of Ana Sofia Rocha Batalha	Bioengenharia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/09 - 2023/05/30	3D cell models to study the contribution of the glioma cell - microglia molecular crosstalk to the immunosuppressive microenvironment Co-supervisor	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2018/01/01 - 2022/07/04	Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer Co-supervisor of Ana Rita Soares Mendes	Bioengenharia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2017 - 2021/12/17	The impact of the genetic risk factor BIN1 to Alzheimer’s disease development Co-supervisor of Catarina Benavente Perdigão	Bioengenharia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017 - 2021/07/22	Three-dimensional culture approaches to advance representation of the tumor microenvironment in preclinical and translational research Supervisor of Maria Teresa Franchi Mendes	Bioengenharia (PhD) Instituto de Biologia Experimental e Tecnológica, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/09 - 2021/06/17	A 3D hepatic model to address immune-mediated drug hepatotoxicity Supervisor of Jhenifer de Farias Oliveira	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal
2019/09 - 2021/05/12	Pre-Clinical Evaluation of Targeted Therapies Using 3D Cell Models of Breast Cancer Co-supervisor of Gonçalo Santos Moura Trindade	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal
2015 - 2020/10/01	Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies Supervisor of Ana Luísa Pécurto Cartaxo	Bioengenharia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09 - 2020/01	Exploring induced pluripotent stem cell-derived 3D neural cultures to model Mucopolysaccharidosis type VII Supervisor of Beatriz Alexandra Carones Painho	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09 - 2019/10	Exploring Tumor-Macrophage Interaction in Anaplastic Thyroid Cancer Co-supervisor of Rodrigo Manuel Ferreira Eduardo	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2019/05	Development of cell models for translation cancer research Supervisor of Sofia de Almeida Santos de Castro e Abreu	Bioengenharia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09 - 2019/01	Patient-derived cultures for cancer modelling Co-supervisor of Marta Carolina Jesus Teixeira	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09 - 2018/11	Depicting the tumor-associated macrophage phenotype employing 3D breast cancer cell models Supervisor of Nuno Filipe Lavos Lopes	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/08 - 2018/11	Identificação de Glicanos no estudo do Microambiente Tumoral Co-supervisor of Ana Margarida Coelho Marques	Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2018/11	Novel cell models to study breast tumour microenvironment and disease progression Supervisor of Marta Maria Vieira Matutino Falcão Estrada	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - 2018/07	Targeting Cancer Vulnerabilities: From molecular targets to antitumor immunity Co-supervisor of Ana Catarina Pereira Pinto	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2018/04	Novel human iPSC-derived neurological disease models Supervisor of Ana Paula Barreto Terrasso	Ciências da Engenharia e Tecnologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012 - 2017/12	Deciphering the potential of blackberry polyphenols for Parkinson Disease: digestion, bloof brain barrier transposition and neuroprotective effect Co-supervisor of Inês Margarida Lourenço Figueira	Bioquímica (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/09 - 2016/10	Chemical synthesis of new histone deacetylase inhibitors and their evaluation as anticancer agents Co-supervisor of Diana Oliveira da Silva	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2015/12	Development of human central nervous system 3D in vitro models for preclinical research Supervisor of Daniel Filipe Mestre Simão	Bioengenharia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/09 - 2015/10	Novel in vitro human 3D neural model derived from induced pluripotent stem cells Supervisor of Francisca Maria de Andrade Terras Arez	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/07 - 2015/06	Development of 3D in vitro models for prediction of hepatic metabolism and toxicity Co-supervisor of Sofia Raquel Paulo Rebelo	Bioengenharia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/09 - 2014/10	Development of 3D cancer cell models for pre-clinical research: evaluation of the tumour microenvironment in 3D stirred-systems Supervisor of Susana Caçador Veloso	Biotecnologia Farmacêutica (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/09 - 2013/11	Evaluation of Chemotherapeutic Potencial of Natural Extracts Using 3D Models of Colon Cancer Co-supervisor of Inês Alexandra Marreiros da Silva	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/09 - 2012/11	Novel human Central Nervous System 3D in vitro models: useful tools for evaluation of viral vector-mediated gene deliver Supervisor of Ana Catarina Pereira Pinto	Biologia Molecular e Genética (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/07 - 2011/11	Development of novel human cellular models for neurotoxicity studies Supervisor of Ana Paula Barreto Terrasso	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2015 - Current	ESACT Drug Discovery Course (2014) Workshop (Co-organisor)	European Society for Animal Cell Technology (ESACT), Germany
2014/12/15 - 2015/11/15	9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2015/10/15 - 2015/10/16) Conference (Member of the Organising Committee)	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2020/02/17	Molecular mechanisms involved in peritoneal dissemination of ovarian cancer: emphasis on the role of mesothelin (Thesis) Main arguer	Ricardo Jorge Bouça-Nova Coelho (PhD) Universidade do Porto Faculdade de Medicina, Portugal
2019/12/02	Study of 3D tumor spheroids for biomedical applications (Thesis) Main arguer	Elisabete Cristina da Rocha Costa (PhD) Universidade da Beira Interior, Portugal
2019/09/06	Bioengineering 3D models to deconstruct the role of extracellular matrix microenvironment in gastric cancer (Thesis) Main arguer	Bianca do Nascimento Lourenço (PhD) Universidade do Porto Faculdade de Engenharia, Portugal
2019/06/17	Intercellular relationships in the tumor microenvironment: implications for cancer pathophysiology (Thesis) Main arguer	Ana Isabel Ferreira de Oliveira (PhD) Universidade do Minho, Portugal
2018/06/26	Colorectal tumor microenvironment: unravelling the interplay between macrophages and the extracellular matrix (Thesis) Main arguer	Marta Laranjeiro Pinto (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/05/12	Development of a new 2D-bioreactor based on openmicrofluidic concept for high-throughput analysis in tissue engineering and biotechnological applications (Thesis) Main arguer	Nuno Miguel Ribeiro de Oliveira (PhD) Universidade do Minho, Portugal
2017	Molecular mechanisms underlying the action of histone deacetylases inhibitors (HDACIs) in ovarian cancer (Thesis) Arguer	FERNANDA MARIA GONÇALVES DA SILVA (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010	Novel Cryopreservation Strategies for Cell-therapies and Pre-clinical Research (Thesis) Arguer	Rita Maria Martins de Sousa Maia Malpique (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Association member

	Society Organization name	Role
2020/12 - Current	European Federation of Biotechnology (EFB)	Member of the Division of Biopharmaceutical and Medical Biotechnology
2013 - Current	Portuguese Association for Cancer Research
2012 - Current	European Association for Cancer Research (EACR)
2008 - Current	Portuguese Society for Stem Cells and Cell Therapies	Coordinator of the "Science and Technology of Stem Cells" Section
2008 - Current	European Society for Animal Cell Technology
1999 - Current	Portuguese Society of Biochemistry

Committee member

	Activity description Role	Institution / Organization
2018 - Current	Management Board Member	iNOVA4Health, Portugal
2013 - Current	Executive Committee of the PhD Program in Molecular Biosciences (MolBioS) Member	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - Current	Coordinator of the Biopharmaceutical Technology Profile of the PhD program in Molecular Biosciences (MolBioS) Coordinator	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2018	Scientific Board of the Analytical Services Unit President / Vice-president	Instituto de Biologia Experimental e Tecnológica, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2013 - Current	Tools for Discovery and Preclinical Research	Biociências Moleculares (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2023 - 2023	Call for Technology Convervenge for Enabling technologies Member	Norges forskningsråd, Norway	Norges forskningsråd
2020 - 2022	Referee and Member of the Evaluation Panel, Oncology Member	Norges forskningsråd, Norway	Norges forskningsråd
2019 - 2020	Plan Cancer: Novel Experimental Models for Cancer Research: optimization of 3R	Alliance nationale pour les sciences de la vie et de la santé, France INSERM, France
2017 - 2017	Joint trans-national call for multinational research projects for pathway analysis (Pathways 2017)	EU Joint Programme Neurodegenerative Disease Research, Germany

Journal scientific committee

	Journal title (ISSN)	Publisher
2020 - Current	Frontiers in Molecular Neuroscience (1662-5099)	Frontiers
2019 - Current	Scientific Reports (2045-2322)	Springer Science and Business Media LLC
2019 - Current	Frontiers in Toxicology (2673-3080)	Frontiers Media SA

Distinctions

Award

2015	Scientific Merit Award from Santander Totta/ New University of Lisbon Banco Santander Portugal, Portugal