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Julie Cécile Caroline Ribot completed her PhD in 2006 by Université Paul Sabatier Toulouse III, France. During her PhD, made important contributions to the characterization of the development of regulatory T cells in the murine thymus. In 2007, she joined the Instituto de Medicina Molecular-João Lobo Antunes in Lisbon as a postdoc, before being awarded in 2015 and 2021 prestigious 5-year contracts funded by FCT/ Portuguese Ministry of Science. She has embraced this outstanding opportunity towards establishing her scientific independence and developing new lines of research, driven by her passion of questioning how the immune system impacts on tissue physiology. Supported by her host institute, she has recently been selected as Group Leader to co-head the Ribot Silva Santos lab at iMM (2023). She is currently supervising one post-doctoral fellow, one Master student and two Research Fellows. while had also successfully supervised 5 Master students (all of them have integrated competitive PhD programs), and two pHD students (both now working for famous pharmaceutical companies). Her independent line of research has recently identified a meningeal immune population that regulate neuropathophysiology, namely regulating short-term memory in health (Ribeiro et al, Science Immunology, 2019) and disease (Brigas et al, Cell Reports, 2021). She published 2 sections of books and 31 articles in journals, including 11 (co-) first and 9 senior authorships (h factor: 22, over 3000 citations) . She participated in 40 events, gave 28 oral presentations and has received 21 awards. She participated as Principal investigator in 5 projects, co-Principal investigator in 1 project, Researcher in 1 project and Post-doc in 1 project. As principal investigator, she has been awarded 1 FCT Investigator grant (including exploratory funding) as well as 4 project grants, 3 from FCT and 1 from FIS-INFARMED, securing over 700 000 euros. She is regularly invited to act as examiner in PhD and MSc dissertations at Portuguese and French academic institutions, and has been involved in advanced teaching at University of Lisbon, as invited lecturer for the Lisbobimed and NeurULisboa PhD Programs and Perseptorship in Immunology.
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Identification

Personal identification

Full name
Julie Cécile Caroline Ribot
Date of birth
1981/07/02
Gender
Female

Citation names

  • Ribot, Julie

Author identifiers

Ciência ID
7C1C-F771-97C9
ORCID iD
0000-0002-7852-343X

Addresses

  • Instituto de Medecina Molecular. Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2006
Concluded
 Doutoramento (Doctorat)
Université Paul Sabatier Toulouse III - Faculté de Médecine Purpan, France
"Role of thymic epithelial cells in regulatory T cell differentiation" (THESIS/DISSERTATION)
 "mention très honorable"
2003
Concluded
 Mestrado (DEA)
Université Paul Sabatier Toulouse III - Faculté de Médecine Purpan, France
"Thymic development of CD4+ regulatory T cells" (THESIS/DISSERTATION)
 "mention bien" (15/20)
2001
Concluded
 Licenciatura (Licence)
Université de Tours, France
"Diagnosis of coccidiosis in chickens. Identification of species specific antigenic markers" (THESIS/DISSERTATION)
 "mention bien" (14.7/20)
Affiliation

Science

Category
Host institution 		Employer
2023/04/01 - 2029/03/03 Principal Investigator (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021 - 2027 Principal Investigator (Research) Instituto de Medicina Molecular, Portugal
2015 - 2020 Principal Investigator (Research) Instituto de Medicina Molecular, Portugal
2007 - 2015 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2006 - 2007 Postdoc (Research) INSERM, France
Projects

Grant

Designation Funders
2022/01/01 - Current Meningeal Immunity and NeuroInflammation: deciphering the immune cells intervening in neonatal bacterial meningitis (E 50 000)
EXPL/SAU-INF/1217/2021
Co-PI
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2025/12/31 Deciphering the role of IL-17 on peripheral nerve regeneration
2022.01244.PTDC
10.54499/2022.01244.PTDC
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/03 - 2024/03 Regulating meningeal gd17 T cell homeostasis: Molecular mechanisms and pathophysiological implications (E 250 000)
PTDC/MED-IMU/1988/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
2018 - 2021 Meningeal gd 17 T cells: impact on cognitive functions in health and disease (€ 240 000)
LISBOA-01-0145-FEDER-028241
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2020 MicroRNA determinants of the balance between effector and regulatory T cells in vivo (€ 2 000 000)
646701 DevoT(ed)_miR
Researcher
Instituto de Medicina Molecular, Portugal
 European Research Council
Concluded
2015 - 2020 Deciphering the outside-in mechanisms of human gd T cell differentiation (€ 50 000)
IF/00013/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2018 Targeting microRNAs to modulate the differentiation of anti-tumour human gd T cells (€ 90 000)
FIS-2015-01_ONC_20150630-162
Principal investigator
Instituto de Medicina Molecular, Portugal
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP
Concluded
2014 - 2015 Exploring the outside-in mechanisms of human gd T cell differentiation (€ 50 000)
EXPL/IMI-IMU/0170/2013
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2011 Regulation of T cell differentiation and activation by CD27-CD70 receptor-ligand interactions in the thymus and in the periphery
PTDC/SAU-MII/104158/2008
Post-doc
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/04/01 - 2029/03/31 Pathophysiological functions of tissue-resident ¿d17 T cells in health and disease
LA/P/0082/2020
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Ongoing
2021/05/01 - 2027/04/30 Regulating meningeal gd17 T cell homeostasis: Molecular mechanisms and pathophysiological implications
2020.00413.CEECIND
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
2015 - 2020 Deciphering the outside-in mechanisms of human gd T cell differentiation (€ 120 000 salary for 5 years)
IF/00013/2014
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Ribot, Julie C.; Serre, Karine; Silva-Santos, Bruno. "Developmental and Functional Assays to Study Murine and Human gd T Cells". In Methods in Molecular Biology, 257-267. Springer New York, 2017.
    10.1007/978-1-4939-6548-9_18
  2. Romagnoli, P.; Ribot, Julie; Tellier, J; Dr Joost van Meerwijk. "Thymic and peripheral generation of CD4+Foxp3+ regulatory T cells". In Regulatory T cells and clinical application. 2008.
Journal article
  1. Ajendra, Jesuthas; Papotto, Pedro H.; Parkinson, James E.; Dodd, Rebecca J.; Bombeiro, André L.; Pearson, Stella; Chan, Brian H.K.; et al. "The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration". Mucosal Immunology 16 6 (2023): 767-775. http://dx.doi.org/10.1016/j.mucimm.2023.09.006.
    10.1016/j.mucimm.2023.09.006
  2. Silva-Santos, Bruno; Ribot, Julie C.; Adams, Erin J.; Willcox, Benjamin E.; Eberl, Matthias. "¿d T cell explorations seek terra firma". Nature Immunology 24 10 (2023): 1606-1609. http://dx.doi.org/10.1038/s41590-023-01606-x.
    10.1038/s41590-023-01606-x
  3. Bombeiro, André L.; Fernandes, Rodrigo G.Q.; Ribot, Julie C.. "New immune regulators of sciatic nerve regeneration? Lessons from the neighborhood". Neural Regeneration Research 19 4 (2023): 705-706. http://dx.doi.org/10.4103/1673-5374.382241.
    10.4103/1673-5374.382241
  4. Darrigues, Julie; Almeida, Vicente; Conti, Eller; Ribot, Julie C.. "The multisensory regulation of unconventional T cell homeostasis". Seminars in Immunology 61-64 (2022): 101657. http://dx.doi.org/10.1016/j.smim.2022.101657.
    10.1016/j.smim.2022.101657
  5. Gordino, Gisela; Costa-Pereira, Sara; Corredeira, Patrícia; Alves, Patrícia; Costa, Luís; Gomes, Anita Q; Silva-Santos, Bruno; Ribot, Julie C. Corresponding author: Ribot, Julie C. "MicroRNA-181a restricts human ¿d T cell differentiation by targeting Map3k2 and Notch2". EMBO reports 23 1 (2021): http://dx.doi.org/10.15252/embr.202052234.
    10.15252/embr.202052234
  6. Brigas, Helena C.; Ribeiro, Miguel; Coelho, Joana E.; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, Emilie; et al. Corresponding author: Ribot, Julie C.. "IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease". Cell Reports 36 9 (2021): 109574. http://dx.doi.org/10.1016/j.celrep.2021.109574.
    10.1016/j.celrep.2021.109574
  7. Darrigues, Julie; Ribot, Julie C.. Corresponding author: Ribot, Julie C.. "gd T cells, Tregs and epithelial cells interact with IL-33 in the lung". Cellular & Molecular Immunology (2021): http://dx.doi.org/10.1038/s41423-020-00631-2.
    10.1038/s41423-020-00631-2
  8. Ribot, Julie C.; Lopes, Noëlla; Silva-Santos, Bruno. Corresponding author: Ribot, Julie C.. "gd T cells in tissue physiology and surveillance". Nature Reviews Immunology (2020): http://dx.doi.org/10.1038/s41577-020-00452-4.
    10.1038/s41577-020-00452-4
  9. Wilharm, Anneke; Brigas, Helena C.; Sandrock, Inga; Ribeiro, Miguel; Amado, Tiago; Reinhardt, Annika; Demera, Abdi; et al. Corresponding author: Ribot, Julie C.. "Microbiota-dependent expansion of testicular IL-17-producing Vg6+ gd T cells upon puberty promotes local tissue immune surveillance". Mucosal Immunology 14 1 (2020): 242-252. http://dx.doi.org/10.1038/s41385-020-0330-6.
    10.1038/s41385-020-0330-6
  10. Edwards, Sarah C.; Sutton, Caroline E.; Ladell, Kristin; Grant, Emma J.; McLaren, James E.; Roche, Fiona; Dash, Pradyot; et al. "A population of proinflammatory T cells coexpresses ab and gd T cell receptors in mice and humans". Journal of Experimental Medicine 217 5 (2020): http://dx.doi.org/10.1084/jem.20190834.
    10.1084/jem.20190834
  11. Edelblum, Karen; Gustafsson, Kenth; Pennington, Daniel J.; Willcox, Benjamin E.; Ribot, Julie C.. Corresponding author: Ribot, Julie C.. "Bordeaux 2018: Wine, Cheese, and gd T Cells". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.02544.
    10.3389/fimmu.2019.02544
  12. Ribeiro, Miguel; Brigas, Helena C.; Temido-Ferreira, Mariana; Pousinha, Paula A.; Regen, Tommy; Santa, Cátia; Coelho, Joana E.; et al. Corresponding author: Ribot, Julie C.. "Meningeal gd T cell–derived IL-17 controls synaptic plasticity and short-term memory". Science Immunology 4 40 (2019): eaay5199. http://dx.doi.org/10.1126/sciimmunol.aay5199.
    10.1126/sciimmunol.aay5199
  13. Ribot, Julie C.; Neres, Rita; Zuzarte-Luís, Vanessa; Gomes, Anita Q.; Mancio-Silva, Liliana; Mensurado, Sofia; Pinto-Neves, Daniel; et al. "gd-T cells promote IFN-g–dependent Plasmodium pathogenesis upon liver-stage infection". Proceedings of the National Academy of Sciences 116 20 (2019): 9979-9988. http://dx.doi.org/10.1073/pnas.1814440116.
    10.1073/pnas.1814440116
  14. Papotto, Pedro H; Ribot, Julie C; Silva-Santos, Bruno. "IL-17+ gd T cells as kick-starters of inflammation". Nature Immunology 18 6 (2017): 604-611. http://dx.doi.org/10.1038/ni.3726.
    10.1038/ni.3726
  15. Papotto, P.H.; Gonçalves-Sousa, N.; Schmolka, N.; Iseppon, A.; Mensurado, S.; Stockinger, B.; Ribot, J.C.; Silva-Santos, B.. "IL-23 drives differentiation of peripheral gd17 T cells from adult bone marrow-derived precursors". EMBO Reports 18 11 (2017): 1957-1967. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032699569&partnerID=MN8TOARS.
    10.15252/embr.201744200
  16. Ribeiro, S T; Tesio, M; Ribot, J C; Macintyre, E; Barata, J T; Silva-Santos, B. "Casein kinase 2 controls the survival of normal thymic and leukemic gd T cells via promotion of AKT signaling". Leukemia 31 7 (2016): 1603-1610. http://dx.doi.org/10.1038/leu.2016.363.
    10.1038/leu.2016.363
  17. Munoz-Ruiz, M.; Ribot, J.C.; Grosso, A.R.; Gonalves-Sousa, N.; Pamplona, A.; Pennington, D.J.; Regueiro, J.R.; Fernndez-Malavé, E.; Silva-Santos, B.. "TCR signal strength controls thymic differentiation of discrete proinflammatory gdT cell subsets". Nature Immunology 17 6 (2016): 721-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962124784&partnerID=MN8TOARS.
    10.1038/ni.3424
  18. Ribeiro, S.T.; Ribot, J.C.; Silva-Santos, B.. "Five layers of receptor signaling in gd T-cell differentiation and activation". Frontiers in Immunology 6 JAN (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926664201&partnerID=MN8TOARS.
    10.3389/fimmu.2015.00015
  19. Ribot, J.C.; Ribeiro, S.T.; Correia, D.V.; Sousa, A.E.; Silva-Santos, B.. "Human gd thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon il-2/il-15 signaling". Journal of Immunology 192 5 (2014): 2237-2243. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896529469&partnerID=MN8TOARS.
    10.4049/jimmunol.1303119
  20. Coquet, J.M.; Ribot, J.C.; Ba¸bala, N.; Middendorp, S.; van der Horst, G.; Xiao, Y.; Neves, J.F.; et al. "Epithelial and dendritic cells in the thymic medulla promote cd4+foxp3+ regulatory t cell development via the cd27-cd70 pathway". Journal of Experimental Medicine 210 4 (2013): 715-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878646386&partnerID=MN8TOARS.
    10.1084/jem.20112061
  21. Ribot, J.C.; Silva-Santos, B.. "Differentiation and activation of gd T Lymphocytes: Focus on CD27 and CD28 costimulatory receptors.". Advances in experimental medicine and biology 785 (2013): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879006288&partnerID=MN8TOARS.
    10.1007/978-1-4614-6217-0_11
  22. Ribot, J.C.; DeBarros, A.; Mancio-Silva, L.; Pamplona, A.; Silva-Santos, B.. "B7-CD28 costimulatory signals control the survival and proliferation of murine and human gd T cells via IL-2 production". Journal of Immunology 189 3 (2012): 1202-1208. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864130583&partnerID=MN8TOARS.
    10.4049/jimmunol.1200268
  23. Ribot, J.C.; DeBarros, A.; Silva-Santos, B.. "Searching for "signal 2": Costimulation requirements of gd T cells". Cellular and Molecular Life Sciences 68 14 (2011): 2345-2355. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960954029&partnerID=MN8TOARS.
    10.1007/s00018-011-0698-2
  24. deBarros, A.; Chaves-Ferreira, M.; D'Orey, F.; Ribot, J.C.; Silva-Santos, B.. "CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human gd peripheral blood lymphocytes". European Journal of Immunology 41 1 (2011): 195-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650334358&partnerID=MN8TOARS.
    10.1002/eji.201040905
  25. Gonçalves-Sousa, N.; Ribot, J.C.; DeBarros, A.; Correia, D.V.; Caramalho, Í.; Silva-Santos, B.. "Inhibition of murine gd lymphocyte expansion and effector function by regulatory aß T cells is cell-contactdependent and sensitive to GITR modulation". European Journal of Immunology 40 1 (2010): 61-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-74249122510&partnerID=MN8TOARS.
    10.1002/eji.200939715
  26. Monteiro, M.; Almeida, C.F.; Caridade, M.; Ribot, J.C.; Duarte, J.; Agua-Doce, A.; Wollenberg, I.; Silva-Santos, B.; Graca, L.. "Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-ß". Journal of Immunology 185 4 (2010): 2157-2163. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956943528&partnerID=MN8TOARS.
    10.4049/jimmunol.1000359
  27. Nunes-Cabaço, H.; Ribot, J.C.; Caramalho, I.; Serra-Caetano, A.; Silva-Santos, B.; Sousa, A.E.. "Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression". Immunology and Cell Biology 88 5 (2010): 523-528. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954313701&partnerID=MN8TOARS.
    10.1038/icb.2010.4
  28. Ribot, J.C.; Chaves-Ferreira, M.; D'Orey, F.; Wencker, M.; Gonçalves-Sousa, N.; Decalf, J.; Simas, J.P.; Hayday, A.C.; Silva-Santos, B.. "Cutting edge: Adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-g-or IL-17-producing gd T cells upon infection". Journal of Immunology 185 11 (2010): 6421-6425. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650331809&partnerID=MN8TOARS.
    10.4049/jimmunol.1002283
  29. Ribot, J.C.; deBarros, A.; Pang, D.J.; Neves, J.F.; Peperzak, V.; Roberts, S.J.; Girardi, M.; et al. "CD27 is a thymic determinant of the balance between interferon-g- and interleukin 17-producing gd T cell subsets". Nature Immunology 10 4 (2009): 427-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-62849124659&partnerID=MN8TOARS.
    10.1038/ni.1717
  30. Ribot, J.; Enault, G.; Pilipenko, S.; Huchenq, A.; Calise, M.; Hudrisier, D.; Romagnoli, P.; Van Meerwijk, J.P.M.. "Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection". Journal of Immunology 179 10 (2007): 6741-6748. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449091619&partnerID=MN8TOARS.
  31. Ribot, J.; Romagnoli, P.; Van Meerwijk, J.P.M.. "Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire". Journal of Immunology 177 2 (2006): 1101-1107. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745848463&partnerID=MN8TOARS.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/22 Role of IL-17 in peripheral nerve regeneration Harald von Boehmer Midwinter Conference
(Seefeld, Austria)
2023/11/15 gd T cells in tissue pathophysiology 1st HCTI/HSII Infection and Immunity Symposium (Hamburg, Germany)
(Hamburg, Germany)
2023/11/09 gd T cell in tissue pathophysiology French Society for Immunology, Innate T Cell Club Meeting (Montpellier, France)
(Montpellier, France)
2023/03/29 gd T cell in tissue pathophysiology Portuguese Society for Immunology, Annual Meeting (Aveiro, Portugal)
(Aveiro, Portugal)
2023/01/25 gd T cell in tissue pathohysiology TissueHome symposium (Vienna, Austria)
(Vienna, Austria)
2022/12/07 gd T cell in tissue pathophysiology British Society for Immunology, Annual Meeting (Liverpool, UK)
(Liverpool, United Kingdom)
2022/02/16 gd T cells in tissue pathophysiology Immunology Seminars
University of Cardiff, UK (online)
2021/10/20 gd T cells in tissue pathophysiology Immunoconcept seminar
University of Bordeaux, France (Bordeaux, France)
2021/05/30 “Emerging Roles of T Cells in CNS Health and Disease” Society of Biological Psychiatry
2020/09/07 Meningeal gd T cells impact on cognition in health and disease 3rd online gamma delta TCR Workshop of the FOR 2799
2020/03/11 Pathophysiological functions of gd T cells TKI internal Seminar
(Bern, Switzerland)
2019/11/14 Unconventional functions for unconventional T cells French Immunology Society, Annual Meeting
(Nantes, France)
2019/06/14 T cell development, with a little help from CD27 Symposium Paola Romagnoli
(Toulouse, France)
2018/06/09 gd17 T cells infiltrate the male reproductive tract at puberty to keep pathogens at bay 8th International gd T cell conference
(Bordeaux, France)
2017/05/27 Analysing T cell subsets within the Central Nervous System in health and disease. XV Congress of the Sociedade Ibérica de Citometria
(Belem, Portugal)
2017/05/25 gd T cells are the major source of IL-17 in the meninges and control brain cognitive functions. Sociedade Portuguesa de Neurociencias, Annual Meeting
(Braga, Portugal)
2017/05/17 Elucidating the impact of IL-17 on memory: From physiology to Alzheimer’s Disease XLV SPI Annual Meeting
(Coimbra, Portugal)
2017/01/17 Impact of meningeal gd T cells on animal behaviour Post-Doc meeting, iMM Lisboa
instituto de medicina molecular (Lisboa, Portugal)
2016/06/18 gd T cells are the major source of IL-17 in the meninges and control brain cognitive functions. 7th International gd T cell conference
(London, United Kingdom)
2016/04/04 Analysing T cell subsets within the Central Nervous System in health and disease. Symposium “Cell Functional And Phenotypical Analysis”
(Braga, Portugal)
2013/12/19 Molecular determinants of thymocytes differentiation. SPI Workshop Thymus@Porto II
(Porto, Portugal)
2013/03/19 Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27/CD70 pathway. 2nd World Immunology Online Conference
2012/11/26 Human gd thymocytes are functionally immature and require IL-2 signals to differentiate into type 1 cytotoxic lymphocytes. Sociedade Portuguesa de Imunologia, Annual Meeting
(Porto, Portugal)
2012/09/06 CD70 on dendritic and epithelial cells in the thymic medulla promotes CD4+ regulatory T cell development via CD27 European Congress of Immunology
(Glasgow, United Kingdom)
2012/06/16 CD70 on dendritic and epithelial cells in the thymic medulla promotes CD4+ regulatory T cell development via CD27. EMBO fellow meeting
(Heidelberg, Germany)
2011/11/29 CD70 on dendritic and epithelial cells in the thymic medulla promotes CD4+ regulatory T cell development via CD27. Sociedade Portuguesa de Imunologia, Annual Meeting
(Oeiras, Portugal)
2010/05/20 CD27 controls the thymic differentiation and peripheral expansion of Interferon-g producing gd T cells 4th International gd T cell conference
(kiel, Germany)
2009/09/18 Thymic CD70-CD27 signals promote the differentiation of aß and gd T cell subsets. International Cytokine Society
(Lisbon, Portugal)
2008/05 Novel developmental and functional subsets of murine gd T cells. 3rd International gd T cell conference
(Marseille, France)
2008/01 Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection EuroThymaide Symposium
(Toulouse, France)
2007/11 Role of CD27 in aß regulatory and gd T cell activation and differentiation. Sociedade Portuguesa de Imunologia, Annual Meeting
(Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Impact of Ketamine and Xylazine on the peripheral immune landscape
Supervisor of Raquel Moura
 Neuroimmunology
Instituto de Medicina Molecular, Portugal
2022/09/01 - Current Impact of stress on tissue resident gd17 T cells
Supervisor of Deniz Bulgur
 Neuroimmunology (Other)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/01/04 - Current Impact of gd T cells on the Peripheral Nervous System
Supervisor of André Bombeiro
 Neuroimmunology (Post Doc) (Other)
Instituto de Medicina Molecular, Portugal
2018/12 - Current Impact of the circadian rythms on the homeostasis of meningeal gd T cells
Supervisor of Julie Darrigues
 Immunology (Post Doc) (Other)
Instituto de Medicina Molecular, Portugal
2018/01 - Current Impact of micro-RNAs in human gd T cell differentiation
Supervisor of Gisela Gordino
 Immunology (PhD)
Instituto de Medicina Molecular, Portugal
2023/01/01 - 2024/02/01 Role of IL-17- Microbiota crosstalk in nerve regeneration
Supervisor of Rodrigo Q.C Fernandes
 Neuroimmunology (Master)
Instituto de Medicina Molecular, Portugal
2022/01/01 - 2024/01/01 Role of IL-17 on sleep pathophysiology
Supervisor of Eller Conti
 Neuroimmunology (PhD)
2021/09/01 - 2023/03/05 Role of IL-17 in sciatic nerve regeneration
Supervisor of Vladimir Ghilas
 Neuroimmunology (Master)
Instituto de Medicina Molecular, Portugal
2021/09/01 - 2022/11/27 Regulation of meningeal gd17 T cell homeostasis by stress-mediated signals
Supervisor of Vicente Almeida
 Neuroimmunology (Master)
Instituto de Medicina Molecular, Portugal
2019/09 - 2020/10 Impact of meningeal gd T cells in Alzheimer's disease
Supervisor of Sara Pereira
 Neuroimmunology (Master)
Instituto de Medicina Molecular, Portugal
2020/05 - 2020/07 Role of miR135b on gd T cell anti tumour functions in breast cancer
Supervisor of Nour Issaoui
 Immunology (Degree)
Instituto de Medicina Molecular, Portugal
2016/01 - 2020/06 Role of IL-17+ gd T cells in the pathophysiology of the central nervous system
Supervisor of Helena Brigas
 Neuroimmunology (PhD)
Instituto de Medicina Molecular, Portugal
2014/05 - 2020/02 Physiological relevance of IL-17+ gd T cells in the meninges
Supervisor of Miguel Ribeiro (Research Fellow)
 Neuroimmunology (Other)
Instituto de Medicina Molecular, Portugal
2019/04 - 2019/07 Immune fingerprints of Alzheimer's disease
Supervisor of Margarida Cruz
 Immunology (Degree)
NOVA medical school, Portugal
2017/06 - 2018/06 Unravelling the role of miR-181a in human gd T cell anti-tumor functions
Supervisor of Sara Pereira
 Immunology (Degree)
Instituto de Medicina Molecular, Portugal
2016/06 - 2017/06 Blood profiling of immune mediators in newborns with Ischemic Hipoxic Encephalopathy
Supervisor of Beatriz de Sa
 Immunology (Master)
GAPIC - Medicina, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2015/09 - 2016/09 Deciphering the post-transcriptional mechanisms that regulate the effector functions of human gamma delta T cells
Supervisor of Gisela Gordino
 Immunology (Master)
Instituto de Medicina Molecular, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/09/07 - 2023/09/09 “Pre-Clinical Models of Nerve Injury” workshop from the 2023 IASP International Conference on Neuropathic Pain. (2023/09/07 - 2023/09/09)
Conference (Co-organisor)
2023/06/20 - 2023/06/24 Organization of the internnational gd T cell conference (2023/06/20 - 2023/06/23)
Conference (Co-organisor)
2015/06/12 - 2015/06/13 Thymus@Lisbon (2015/06/12 - 2015/06/13)
Symposium (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/01/20 - 2024/01/24 Selected abstract for oral presentation
Conference
 Midwinter Conference. Seefeld, Austria
2023/11/14 - 2023/11/16 Invited speaker
Symposium
 1st HCTI/HSII Infection and Immunity Symposium (Hamburg, Germany)
2023/11/08 - 2023/11/10 Invited speaker
Symposium
 French Society for Immunology, Innate T Cell Club Meeting (Montpellier, France)
2023/03/27 - 2023/03/30 Invited speaker
Congress
 Portuguese Society for Immunology, Annual Meeting ( Aveiro, Portugal)
2023/01/24 - 2023/01/26 Invited speaker
Symposium
 TissueHome symposium, Vienna
2022/12/07 - 2022/12/09 Invited speaker
Congress
 British Society for Immunology, Annual Meeting
2022/02/16 - 2022/02/16 Invited speaker
Seminar
 Immunology Seminars
2021/11/05 - 2021/11/08 Poster presentation
Congress
 9th International gd T cell conference
2021/10/20 - 2021/10/20 Invited speaker
Seminar
 Immunoconcept seminar
Université de Bordeaux, France
2021/05/27 - 2021/05/30 Invited speaker
Congress
 Society of Biological Psychiatry
2019/11/12 - 2019/11/14 Invited speaker
Meeting
 Annual Meeting - Société Française de Immunologie
2019/06/14 - 2019/06/14 Invited speaker
Symposium
 Symposium in memoriam Paola Romagnoli
2019/05/26 - 2019/05/31 Poster presentation
Congress
 AD/PD meeting
2019/04/29 - 2019/04/29 Animation of hand on activities for high school students
Exhibition
 International Immunology Day
2018/06/07 - 2018/06/10 Oral communication
Conference
 8th International gd T cell conference
2017/09/29 - 2017/09/29 Animation of hands on activities for general public
Exhibition
 European Researchers' night
2017/05/25 - 2017/05/27 Invited speaker
Congress
 XV Congress - Sociedade Ibérica de Citometria
2017/05/25 - 2017/05/27 Oral communication
Meeting
 Annual Meeting - Sociedade Portuguesa de Neurociencias
2017/05/17 - 2017/05/19 Oral presentation
Meeting
 XLV SPI Annual Meeting
2016/06/13 - 2016/06/16 Oral communication
Conference
 7th International gd T cell conference
2016/06/01 - 2016/06/03 Oral communication
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2016/04/04 - 2016/04/05 Invited speaker
Symposium
 Symposium “Cell Functional And Phenotypical Analysis” - Universidade do Minho
2013/12/11 - 2013/12/12 Invited speaker
Workshop
 Workshop Thymus@Porto II - Sociedade Portuguesa de Imunologia
2013/06/15 - 2013/06/16 Poster presentation
Symposium
 EMBO Young Scientists’ Forum
2013/03/19 - 2013/03/21 invited speaker
Conference
 2nd World Immunology Online Conference
2012/11/25 - 2012/11/27 Oral communication
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2012/09/05 - 2012/09/08 Oral communication
Congress
 European Congress of Immunology
2012/06/14 - 2012/06/17 Invited speaker
Meeting
 EMBO fellow meeting
2012/05/31 - 2012/06/02 Poster presentation
Conference
 5th International gd T cell conference
2011/11/29 - 2011/11/30 Oral communication
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2011/10 - 2011/10 Poster presentation
Workshop
 Workshop Thymus@Porto - Sociedade Portuguesa de Imunologia
2010/09/20 - 2010/09/22 Poster presentation
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2010/05/19 - 2010/05/21 Oral communication
Conference
 4th International gd T cell conference
2009/10/17 - 2009/10/21 Oral communication
Congress
 Annual meeting - International Cytokine Society
2009/10 - 2009/10 Poster presentation
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2009/09/13 - 2009/09/16 Poster presentation
Congress
 European Congress of Immunology
2008/05 - 2008/05 Oral communication
Conference
 3rd International gd T cell conference
2008/01 - 2008/01 Invited speaker
Symposium
 EuroThymaide Symposium
2007/11 - 2007/11 Poster presentation
Congress
 Annual Meeting - Sociedade Portuguesa de Imunologia
2007/11 - 2007/11 Oral communication
Meeting
 Annual Meeting - Sociedade Portuguesa de Imunologia
2006/09/06 - 2006/09/09 Poster presentation
Congress
 European Congress of Immunology
2005/11 - 2005/11 Poster presentation
Congress
 Annual Meeting - Société Française de Immunologie

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/06 Interactions spécifiques de l'antigène entre les lymphocytes T CD8 et les cellules endothéliales de la barrière he´mato-ence´phalique : me´canismes et conséquences
(Thesis) Main arguer
 Carmen Gonzalez (PhD)
Université Toulouse III-Paul Sabatier, France
2023/12/01 Re´ponse immune et sa modulation au cours de l’infection a` CMV chez le patient transplante´ re´nal
(Thesis) Arguer
 Hannah Kaminsky (Aggregation)
Université de Bordeaux, France
2022/12/19 Impact of adipose tissue colonization by Trypanosoma brucei during infection
(Thesis) Arguer
 Henrique Machado (PhD)
Instituto de Medicina Molecular, Portugal
2022/02/02 Regulation of type 2 innate lymphoid cells at barrier sites
(Thesis) Arguer
 Filipa Cardoso (PhD)
Universidade de Lisboa, Portugal
2021/10/19 Role of memory gd T cells in orchestrating the immune response against murine CMV
(Thesis) Arguer
 Nathalie Yared (PhD)
Université de Bordeaux, France
2021/02/17 The crosstalk between immune mediators and cognition
(Thesis) Arguer
 Claudia Miranda (PhD)
Universidade do Minho, Portugal
2019/12/12 Rôle des populations lymphocytaires innées dans la pneumonie grave et le Syndrome de Détresse Respiratoire Aiguë
(Thesis) Arguer
 Youenn Jouan (PhD)
Université de Tours, France
2019/11/19 Differentiation and pathophysiological functions of Type 2 Lymphoid Cells in the adipose tissue
(Thesis) Main arguer
 Gonçalo Malpica (Master)
Universidade Nova de Lisboa Departamento de Imunologia, Portugal
2018/05/29 Refining thymic epithelial cell differentiation: from progenitor cell isolation to the identification of discrete mature lineages
(Thesis) Main arguer
 Catarina Meireles (PhD)
Universidade do Porto, Portugal
2017/06/27 Immune profile characterization of an Alzheimer's disease mice model
(Thesis) Main arguer
 Vitor Ferreira (Master)
Universidade do Minho, Portugal
2016/01/20 The role of IFN-g in brain functions, in health and upon chronic stress
(Thesis) Main arguer
 Susana Monteiro (PhD)
Universidade do Minho, Portugal
2015/11/16 Role of diet- derived Retinoids in intraepithelial lymphocytes
(Thesis) Main arguer
 Bruno Raposo (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2012/12/04 The role of kupffer cells in the pathophysiology of cerebral malaria
(Thesis) Main arguer
 Francisco Vidal (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Association member

Society Organization name Role
2016 - Current Sociedade Portuguesa de Neurociencias Member
2008 - Current Sociedade Portuguesa de Imunologia Member

Conference scientific committee

Conference name Conference host
2017 - Current AIMS Meeting Research Competition Faculty of Medicine, Lisbon, Portugal
2015 - Current Dia da Investigação Faculdade de Medicina, Universidade de Lisboa
2021/11/08 - 2021/11/12 International Society of Neuroimmunology (ISNI) University of Nice, France
2021/11/05 - 2021/11/09 9th International gd T cell conference University of Beijing, China
2018/06/07 - 2018/06/10 8th International gd T cell conference Julie Dechanet Merville

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09 - Current Immunology for PhD program Immunology Instituto Gulbenkian de Ciência, Portugal
2022/02 - Current Lisbon Biomed PhD Program Neuroimmunology Instituto de Medicina Molecular, Portugal
2022/01 - Current Immunology, PhD program Lisbon Biomed PhD progam Instituto de Medicina Molecular, Portugal
2021/01 - Current Translational and Precision Medicine course of NBR master Program (Mestrado) NOVA medical school, Portugal
2017 - 2018 NeurULisboa PhD Program (Curso de doutoramento (conclusão de unidades curriculares)) Instituto de Medicina Molecular, Portugal
2015 - 2018 Perseptorship in immunotherapy (Faculdade de Medicina de Lisboa) Basic Medicine (Outros) Instituto de Medicina Molecular, Portugal
2006/01/01 - 2007/06/30 Master in Immunology program Immunology - T cell development (Master) Université Paul Sabatier Toulouse III - Faculté de Médecine Purpan, France

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020/08 - Current External reviewer of projects for the Czech Science Foundation
Evaluator
 Grantová agentura Ceské republiky, Czech Republic Grantová agentura Ceské republiky
2020/02 - Current External scientific evaluator "Fondation pour la Recherche Médicale"
Evaluator
 Fondation pour la Recherche Médicale, France Fondation pour la Recherche Médicale

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/09/22 Media coverage for Brigas et al, Cell Reports, 2021 Publico
2021/09/22 Media coverage for Brigas et al, Cell Reports, 2021 Saude online
2019/12/20 Research highlight for Ribeiro et al, Science Immunol, 2019 Nature Immunology
2019/12/19 Research highlight for Ribeiro et al, Science Immunol, 2019 Nature Review Immunology
2019/11/10 Media coverage for Ribeiro et al, Science Immunol, 2019 Alzforum
2019/10/14 Media coverage for Ribeiro et al, Science Immunol, 2019 Cosmomag
2019/10/11 Media coverage for Ribeiro et al, Science Immunol, 2019 Technology Network
2019/07/12 Media coverage for Ribeiro et al, Science Immunol, 2019 Publico
2013/04/19 Research highlight for Coquet* Ribot* et al, J. Exp. Med., 2013 Nature Review Immunology
2009/09/12 Media coverage for Ribot et al, Nature Immunol. 2009 Science in School

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current The Journal of Experimental Medicine - ad hoc referee Rockefeller University Press
2021 - Current Cellular and Molecular Immunology - ad hoc referee Elsevier
2020 - Current Cell Reports - ad hoc referee Cell Press
2016 - Current Frontiers in Immunology - ad hoc referee (1664-3224) Frontiers Media SA
2016 - Current Infection and Immunity - ad hoc referee (1098-5522) American Society for Microbiology
2016 - Current European Journal of Immunology - ad hoc referee (1521-4141) Wiley (John Wiley & Sons)
2015 - Current PLoS ONE - ad hoc referee (1932-6203) Public Library of Science
2015 - Current Stem Cells and Development - ad hoc referee (1557-8534) Mary Ann Liebert
2015 - Current Journal of Immunology Research - ad hoc referee (2314-7156) Hindawi Limited

Mentoring / Tutoring

Topic Student name
2022/01/01 - Current Molecular Biology Alice Borges
2021 - Current Regulation of IEL homeostasis in the murine intestine, Gonçalo Malpica (PhD thesis committee)
2020/01 - Current Immunology Rodrigo Pedroso
2018/01/01 - Current How to activate non-conventional Epithelial T cells Patricia Campos (PhD committee)
2017/01/01 - Current Can the modulation of the crosstalk between Systemic Immune System and Central Nervous System ameliorate the depressive- and anxiety-like behaviour induced in Social Isolated mice? Daniela Cristina Melo Magalhães (PhD thesis committee)
2018/06/01 - 2021/01/01 Genetic, molecular and cellular control of regulatory T cell development Jeremy Santamaria (PhD thesis committee)
Distinctions

Award

2020 Pfizer award for basic research
Laboratórios Pfizer Ltda, Brazil
2017 Best oral presentation
Instituto de Medicina Molecular, Portugal
2016 Best oral presentation award (Prémio Arala Chaves) (€ 250)
Sociedade Portuguesa de Imunologia, Portugal
2016 Travel award (€ 400)
gd conference organization, United Kingdom
2015 Travel award (€ 500)
Sociedade Portuguesa de Imunologia, Portugal
2012 Travel award (€ 500)
Sociedade Portuguesa de Imunologia, Portugal
2012 Travel award (€ 500)
gd conference organisation, Germany
2010 Travel award (€ 500)
gd conference organization, Germany
2010 International Award - 5th Edition, 2nd place (€ 5,000)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2009 Post-doctoral investigation award, 1st place ($ 800)
International Cytokine Society, United States
2009 Best immulogy paper award (€ 2,500)
Sociedade Portuguesa de Imunologia, Portugal

Other distinction

2020 CEEC FCT 6 year contract
Fundação para a Ciência e a Tecnologia, Portugal
2017 Research grant (€ 240 000)
Fundação para a Ciência e a Tecnologia, Portugal
2016 Research grant (€ 90 000)
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2014 Investigador FCT (€ 120 000 salary for 5 years + € 50 000 exploratory grant)
Fundação para a Ciência e a Tecnologia, Portugal
2013 Exploratory Grant (€ 50.000)
Fundação para a Ciência e a Tecnologia, Portugal
2012 Post-doctoral fellowship (€ 53,820 salary for 3 years)
Fundação para a Ciência e a Tecnologia, Portugal
2009 Post-doctoral fellowship (€ 56,000 salary for 2 years)
European Molecular Biology Organization , Germany
2007 Post-doctoral fellowship (€ 35,880 salary for 2 years)
Fundação para a Ciência e a Tecnologia, Portugal
2006 Post-doctoral fellowship (€ 18,000 salary for 1 year)
INSERM, France
2003 PhD fellowship (€ 37,800 salary for 3 years)
Gouvernement francais Ministere de l'education nationale, France