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Identification

Personal identification

Full name
Inês Tomé Ribeiro

Citation names

  • Tomé, Inês

Author identifiers

Ciência ID
7D12-DDB0-72F6
ORCID iD
0000-0001-8147-1004
Education
Degree Classification
2020/01 - 2024/12
Concluded
 EIT Health@Ageing PhD School (Outros)
EIT Health, Germany
2019/12 - 2023/12/09
Concluded
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Major in Biotecnologia Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Pharmacologic strategies to target cellular senescence " (THESIS/DISSERTATION)
2016 - 2018
Concluded
 Investigação Biomédica (Mestrado)
Major in Ciências Cardiovasculares
Universidade de Coimbra Faculdade de Medicina, Portugal
"Breaking the Barriers of Heart Failure with Preserved Ejection Fraction: a new "blood vessel on a chip" model" (THESIS/DISSERTATION)
 18
2013 - 2016
Concluded
 Farmácia Biomédica (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2023/01 - 2023/03 Visiting Researcher (Research) Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain
2022/02/01 - 2022/08 Visiting Researcher (Research) Mayo Clinic Rochester, United States
Mayo Clinic Graduate School of Biomedical Sciences, United States
2018/08 - 2019/12 Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/07 - 2017/09 Research Trainee (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/04 - 2017/05 Research Trainee (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
CNC.IBILI, Portugal
2017/01 - 2017/02 Research Trainee (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2024/04 - Current Health from portugal (HfPT) - Mobilizing Agendas for Business Innovation aims to develop innovative coatings
7158
Research Fellow
Universidade de Coimbra, Portugal
 Plano de Recuperação e Resiliência (PRR)
2020/01/01 - 2023/12/31 A senolytic delivery system able to cross the blood brain barrier
SFRH/BD/146960/2019
10.54499/SFRH/BD/146960/2019
PhD Student Fellow
Universidade de Coimbra Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Mayo Clinic Rochester, United States
Fundação para a Ciência e a Tecnologia
Concluded
2018/08 - 2019/12 AGING-MODEL: A Progeria vascular model for the identification of smooth muscle cells loss
PTDC/BTM-SAL/29229/2017
Master Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2023/04 - Current SenoLive-Targeted senolytic system to treat liver cirrhosis
2022.02783.PTDC
PhD Student Fellow
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2021/03/01 - 2024/08/31 A therapeutic strategy to fight blood-brain-barrier (BBB) ageing
PTDC/BTM-SAL/5174/2020
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/07 - 2018/08 NETDIAMOND: new targets in diastolic heart failure, from comorbidities to personalized medicine
POCI-01-0145-FEDER-016385
Master Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
European Union
Concluded
Outputs

Publications

Book chapter
  1. Tomé, Inês. "Physiological and Pathological Vascular Aging". In Biophysical Regulation of Vascular Differentiation and Assembly, 51-72. Springer New York, 2018.
    Published
Conference abstract
  1. Tomé, Inês; Sanfeliu-Redondo, David; Peio Aristu-Zabalza; Maria Grazia Vizioli; Rosa, Susana; Pitrez, Patricia R.; Gracia-Sancho, Jordi; et al. Corresponding author: Ferreira, Lino. "Senotherapeutic nanoparticles to target the senescence program in the blood-brain barrier". Paper presented in Annual Meeting of the European Tissue Repair Society (ETRS) and the Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), Coimbra, 2023.
    Published
  2. Sanfeliu-Redondo, David; Francisco, Vitor; Tomé, Inês; Marques, Andreia ; Peio Aristu; Pitrez, João; Rosa, Susana; Ferreira, Lino; Gracia-Sancho, Jordi. Corresponding author: Gracia-Sancho, Jordi. "A novel senolytic nanoformulaton targeing the hepatic sinusoid improves hepatic function and fibrosis in experimental models of aging". Paper presented in The Liver Meeting, Boston, 2023.
    Published
  3. Francisco, Vitor; Marques, Andreia; Sanfeliu-Redondo, David; Pitrez, João; Tomé, Inês; Rosa, Susana; Gracia-Sancho, Jordi; Ferreira, Lino. Corresponding author: Ferreira, Lino. "Efficient senotherapeutic nanoparticles targeting senescent cells". Paper presented in Annual Meeting of the European Tissue Repair Society (ETRS) and the Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), Coimbra, 2023.
    Published
  4. E Silva; I Tome; F Vasques-Novoa; A Silva; G Conceicao; D Miranda-Silva; P Pitrez; et al. "Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction". 2022.
    Published • 10.1093/cvr/cvac066.107
  5. Tomé, Inês. "Endothelial Dysfunction in the context of Heart Failure with Preserved Ejection Fraction (HFpEF)". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Coimbra, 2019.
Conference poster
  1. Tomé, Inês; Rosa, Susana; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Francisco, Vitor; Diana Jurk; Ferreira, Lino. "Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles". Paper presented in 18th edition of the PDBEB symposium, (Not) Knowing What Comes Next: Tools for the Research of Tomorrow, 2024.
  2. Tomé, Inês; Rosa, Susana; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Francisco, Vitor; Jurk, Diana; Ferreira, Lino. Corresponding author: Ferreira, Lino. "Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles". Paper presented in Congresso Científico Núcleo de Estudantes de Farmácia (NEF) / Associação Académia de Coimbra (AAC); Longevidade: a ciência do envelhecer, 2024.
  3. Pitrez, João; Marques, Andreia; Tomé, Inês; Rosa, Susana; Francisco, Vitor; Ferreira, Lino. "Senescence in liver sinusoidal endothelial cells: implications for age-related liver changes". Paper presented in 3rd RESETageing Conference, 2023.
  4. Henriques, Mauro; Marques, Andreia; Tomé, Inês; Francisco, Vitor; Ferreira, Lino. "Engineering nanoformulations for senotherapeutics delivery". Paper presented in 3rd RESETageing Conference, 2023.
  5. Novo, João Pedro; Lucy gee; Carolina Caetano; Tomé, Inês; Vilaça, Andreia; Zglinicki, Thomas; Moreira, Irina S; et al. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Paper presented in ETRS & SPCE-TC Joint Meeting 2023, 2023.
  6. Tomé, Inês; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Suana Rosa; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Diana Jurk; Francisco, Vitor; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, 2023.
  7. Tomé, Inês; Elsa Silva; Vasques-Nóvoa, Francisco; Glória Conceição; Andreia Silva; António S. Barros; António Angélico-Gonçalves; et al. Corresponding author: Diana Nascimento. "Pharmacological clearance of senescent cells partially reverses HFpEF hallmarks". Paper presented in Programa de Doutoramento em Biologia Experimental e Biomedicina (PDBEB) Day, 2023.
  8. Tomé, Inês; Elsa Silva; Vasques-Nóvoa, Francisco; Glória Conceição; Andreia Silva; António S. Barros; António Angélico-Gonçalves; et al. Corresponding author: Ferreira, Lino. "Pharmacological clearance of senescent cells partially reverses HFpEF hallmarks". Paper presented in 7th International Cell Senescence Association (ICSA) Conference, 2022.
  9. Tomé, Inês; SILVA, ELSA; Vasques-Nóvoa, Francisco; Glória Conceição; Andreia Silva; António S. Barros; António Angélico-Gonçalves; et al. Corresponding author: Ferreira, Lino. "Pharmacological clearance of senescent cells partially reverses HFpEF hallmarks". Paper presented in 7th International Cell Senescence Association (ICSA) Conference, 2022.
  10. Tomé, Inês; Rosa, Susana; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Jurk, Diana; Francisco, Vitor; Ferreira, Lino. Corresponding author: Ferreira, Lino. "Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles". Paper presented in Pharma PhD Day, 2021.
  11. Tomé, Inês; Pitrez, Patricia R.; Glória Conceição; Francisco Vasques-Nóvoa; Nádia Gonçalves; Girao, Henrique; Pinto-do-Ó, Perpetua; et al. Corresponding author: Ferreira, Lino. "Endothelial Dysfunction in the context of Heart Failure with Preserved Ejection Fraction". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
  12. Tomé, Inês; Pitrez, Patricia R.; Glória Conceição; Francisco Vasques-Nóvoa; Nádia Gonçalves; Girao, Henrique; Pinto-do-Ó, Perpetua; et al. Corresponding author: Ferreira, Lino. "Endothelial Dysfunction in the context of Heart Failure with Preserved Ejection Fraction (HFpEF)". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  13. Tomé, Inês. "A brief history of First World War contribution to Contemporary Medicine: the beginning of a new era". Paper presented in 5º Encontro Nacional de História das Ciências e da Tecnológia/ 2º Congresso Internacional de História Interdisciplinar da Saúde, 2016.
Journal article
  1. Novo, João Pedro; Gee, Lucy; Caetano, Carolina A.; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S.; et al. "Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence". Aging Cell (2024): http://dx.doi.org/10.1111/acel.14270.
    10.1111/acel.14270
  2. Tomé, Inês; Francisco, Vitor; Fernandes, Hugo; Ferreira, Lino. "High-throughput screening of nanoparticles in drug delivery". APL Bioengineering 5 3 (2021): 031511. http://dx.doi.org/10.1063/5.0057204.
    Open access • Published • 10.1063/5.0057204
Preprint
  1. Elsa Silva; Inês Tomé; Francisco Vasques-Nóvoa; Glória Conceição; Andreia Silva; António Barros; António Angélico-Gonçalves; et al. "Pharmacological clearance of senescent cells reverses HFpEF hallmarks by decreasing inflammation, endothelial dysfunction and cardiac fibrosis". 2021. https://doi.org/10.21203/rs.3.rs-624229/v1.
    10.21203/rs.3.rs-624229/v1
Thesis / Dissertation
  1. "Breaking the barriers of HFpEF: a New "Blood Vessel on a Chip" Model". Master, Universidade de Coimbra Faculdade de Medicina, 2018.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03/21 Senolytics targeting the senescence program Longevidade: a ciência do envelhecer
Núcleo de Estudantes de Farmácia (NEF) / Associação Académia de Coimbra (AAC) (Coimbra, Portugal)
2024/03/21 Targeting endothelial senescence in the blood-brain barrier with senotherapeutic nanoparticles Longevidade: a ciência do envelhecer
Congresso Científico Núcleo de Estudantes de Farmácia (NEF) / Associação Académia de Coimbra (AAC) (Coimbra, Portugal)
2023/11/24 Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles PharmaDay - Encontro Anual de Estudantes de Doutoramento em Ciências Farmacêuticas
Faculdade de farmácia da universidade de coimbra (Coimbra, Portugal)
2023/10 Senotherapeutic nanoparticles to target the senescence program in the blood-brain barrier ETRS & SPCE-TC Joint Meeting 2023
(Coimbra, Portugal)
2023/09 Targeting the senescence program in the blood-brain barrier with senotherapeutic nanoparticles European Society of Biomaterials (ESB) 2023
European Society of Biomaterials (Davos, Switzerland)
2019/11/22 Endothelial Dysfunction in the context of Heart Failure with Preserved Ejection Fraction Congresso SPCCTV - Surgery without Borders
Sociedade Portuguesa de Cirurgia Cardiotorácica e Vascular (Albufeira, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/01 - 2019/06 Membro da Comissão Organizadora do evento "Ageing: Models, mechanisms and therapies” (2019/06/28 - 2019/06/29)
Conference (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/04 - Current Science Fairs at schools: Escola Secundária da Lousã (24/04/2024), Escola Ferrer Correia (10/05/2024), Escola Secundária José Falcão (28/05/2024)
Other
 Science Fairs at schools
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/04/16 - 2024/04/17 Lecture to undergraduate pharmacy students regarding the subject of scientific research.
Symposium
 X Jornadas das Saídas Profissionais
Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra (NEF/AAC), Portugal
2023/05/03 - 2023/05/03 Lecture to undergraduate pharmacy students regarding the subject of scientific research.
Symposium
 IX Jornadas das Saídas Profissionais
Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra (NEF/AAC), Portugal
2023/04/20 - 2023/04/20 Former pharmacy students are invited to testify on their experiences working around the world. I have provided my insights as a PhD visiting student working in the United States and in Barcelona.
Other
 Farmacy around the World
Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra (NEF/AAC), Portugal
2021/05/02 - 2021/05/02 Lecture to undergraduate pharmacy students regarding the subject of scientific research.
Symposium
 VII Jornadas das Saídas Profissionais
Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra (NEF/AAC), Portugal
2021/04/01 - 2021/04/02 Lecture about the Biomedical Investigation research
Meeting
 Biomédica tem Futuro! - III Semana de Farmácia Biomédica
Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra (NEF/AAC), Portugal
2016/11 - 2020/11 Outreaching activities
Exhibition
 European Researchers' Night
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Association member

Society Organization name Role
2014/09 - 2015/07 Núcleo de Estudantes de Farmácia (Faculdade de Farmácia da Universidade de Coimbra) Membro do Pelouro da Pedagogia

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/11 - 2022/11 Aula de transcriptómica (teórica e prática) Investigação Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2024/02 - Current Mentoring programme "Find your Carreer" Ana Raquel Silva
2024/02 - Current Mentoring programme "Find your Carreer" Maria Correia
2024/02 - Current Mentoring programme "Find your Carreer" Miguel Guerra Garcia
Distinctions

Award

2023 Best Oral Communication
2020 FCT PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2021 Fulbright Scholarship with the support of FCT
Fulbright Portugal, Portugal
2019 EIT Health Ageing PhD School
EIT Health, Germany