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Inna Uliyakina de Oliveira Lobo is a postdoctoral research scientist with PhD in Biochemistry/Molecular Genetics and vast experience in cellular and molecular biology, microscopy and mammalian cell culture techniques applied to study intracellular trafficking, extracellular vesicles, cell signalling and protein expression, function and interactions, with communication, managerial and leadership skills. Currently, Inna is working on “Metabolic Odyssey in Staphylococcus aureus” project at ITQB, Universidade Nova de Lisboa and Biosystems and Integrative Sciences Institute (BioISI), Universidade de Lisboa, Portugal. Lately, Inna has been exploring the impact of pathogenic bacteria Staphylococcus aureus on human Cystic Fibrosis epithelial cell inflammation, differentiation and repair, an exploratory project funded by BioISI. Previously Inna worked at the Department of Physiology, Anatomy and Genetics at the University of Oxford where developed a novel therapeutic strategy utilizing extracellular vesicles as a carrier to deliver NPC1 protein to lysosomal-storage diseased cells and animals leading to normalization of cholesterol transport and glycosphingolipids levels. This project is currently continued by a world-leading extracellular vesicle therapy company Evox Therapeutics Ltd that will proceed with clinical trials. In 2015 Inna has completed her PhD in “Analysis of CFTR Mutants in Epithelial Cells/Tissues and Testing of CFTR-Repairing Therapies” (supervisor Prof. Dr. Margarida D Amaral) at the Faculty of Sciences of the University of Lisboa, Portugal. Her PhD work involved functional characterization of CF modifier genes identified by GWAS using high-throughput siRNA microscopy screens (studies performed at the Advanced Light Microscopy Facility, EMBL, Heidelberg, Germany); functional analysis of the CFTR mutants in epithelial cells from CF patients and assessment of novel therapeutic strategies. During her career Inna has elaborated, coordinated and performed several national and international research projects both within academia and with pharmaceutical companies. Participated in several international conferences and was awarded with fellowships and prizes. Inna has also supervised graduate/master/PhD students and was a laboratory instructor and lecturer on several workshops. Additionally, Inna has graduated with Honors at Master of Business Administration from Quantic School of Business and Technology in 2019. Knowledge fields: Extracellular Vesicles; Lysosomal Storage Disorders; Rare Diseases; Cystic Fibrosis; Genetic Disorders; Novel Therapeutic Strategies.
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Identification

Personal identification

Full name
Inna Uliyakina de Oliveira Lobo

Citation names

  • Inna Uliyakina

Author identifiers

Ciência ID
7D1D-45C8-BAC6
ORCID iD
0000-0002-7091-2123

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Russian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Ukrainian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2018/10/01 - 2019/08/28
Concluded
 Master Business Administration (Master)
Quantic School of Business and Technology, United States
 Passed with Honors
2016 - 2016/10/24
Concluded
 Animal Management and Welfare (Postgraduate Certificate)
Major in PIL A/B
University of Oxford Biomedical Services, United Kingdom
 approved
2011/04/01 - 2015/07/31
Concluded
 Biochemistry (Doutoramento)
Major in Molecular Genetics
Universidade de Lisboa Faculdade de Ciências, Portugal
"Analysis of CFTR Mutants in Epithelial Cells/Tissues and Testing of CFTR-Repairing Therapies" (THESIS/DISSERTATION)
 Approved with distinction and honours
2007/09/01 - 2009/11/19
Concluded
 Biochemistry (Mestrado)
Major in Medical biochemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Molecular cloning and functional characterization of members of novel family of TMEM16 proteins. Effect of Methylglyoxal." (THESIS/DISSERTATION)
 17
2004/09/01 - 2007/07/24
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"sem tese" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/11/08 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/11/08 - 2018/09/01 Contracted Researcher (Research) Universidade de Oxford - Departamento de Fisiologia, Anatomia e Genética, United Kingdom
Oxford University - Department of Physiology, Anatomy and Genetics, United Kingdom
2012/07/15 - 2013/11/01 Visiting Researcher (Research) European Molecular Biology Laboratory, Germany
2009/08/01 - 2010/12/01 Contracted Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2008/09/01 - 2009/08/01 Contracted Researcher (Research) Universidade de Regensburg - Instituto de Fisiologia, Germany

Others

Category
Host institution 		Employer
2017/01/01 - 2018/11/01 Consulting EVOX Therapeutics , United Kingdom
Oxford University Innovation, United Kingdom
2011/04/01 - 2015/07/30 PhD Student; Supervisors: Prof. Dr. Margarida D. Amaral; "Analysis of CFTR Mutants in Epithelial Cells/Tissues and Testing of CFTR-Repairing Therapies" (FCT Ref: SFRH/BD/69180/2010). Universidade de Lisboa Faculdade de Ciências, Portugal
2009/09/01 - 2012/07/15 Research Scientist at Human Genetics Center Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2009/12/01 - 2010/12/01 Studies of CFTR Splicing Mutations and Testing of Novel CF Corrective Compounds Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Projects

Contract

Designation Funders
2020/02/01 - Current Exploring the impact of Staphylococcus aureus on Cystic Fibrosis epithelial cell inflammation, differentiation and epithelial repair.
BioISI_projects_2020
Principal investigator
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas
Ongoing
2019/11/08 - Current Metabolic Odyssey in Staphylococcus aureus.
PTDC/BIA-BQM/28827/2017
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/11 - Current Metabolic Odyssey in Staphylococcus aureus.
PTDC/BIA-BQM/28827/2017
 Fundação para a Ciência e a Tecnologia
2018 - Current cAMP/PKA signaling dynamics: endoplasmatic reticulum and cytosol.
BHF/DPAG/ZaccoloM
Researcher
Oxford University - Department of Physiology, Anatomy and Genetics, United Kingdom
 BHF Centre of Research Excellence
2017/03/01 - 2018/02/28 Extracellular vesicles-mediated delivery of proteins to treat lysosomal storage-related disorders.
UO/DPAG/WoodMJ
Principal investigator
Universidade de Oxford - Departamento de Fisiologia, Anatomia e Genética, United Kingdom
 EVOX Therapeutics
Concluded
2016 - 2018 Exosome-based Gene Therapy for Huntington's Disease
info:eu-repo/grantAgreement/RCUK/MRC/MR2%FM0077152%F1/GB
Researcher
UK Research and Innovation
Concluded
2015/11/08 - 2017/02/28 Exosome-mediated delivery of ABC transporters to treat genetic diseases including Cystic Fibrosis and Tangier’s disease
OU/DPAG/WoodMJ/UCB
Researcher
University of Oxford Department of Physiology Anatomy and Genetics, United Kingdom
 UCB Pharma SA
Concluded
2012/03/01 - 2015/06/30 Caracterização do controlo de qualidade do reticulo endoplasmatico para a proteína F508del-CFTR: potenciais alvos terapêuticos para a Fibrose Quística
PTDC/SAU-GMG/122299/2010
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/07 - 2013/11 Identification of novel compounds rescuing mutant F508del-CFTR from its endoplasmic reticulum myslocalization: potential novel therapeutic compounds for cystic fibrosis.
EuroBioImaging
Researcher
European Molecular Biology Laboratory - Advanced Light Microscopy Facility, Germany
 Euro-BioImaging ERIC
Concluded
2011 - 2013 Identification of Novel Targets Rescuing of F508del-CFTR Traffic: Mechanism of Action.
7207534
Researcher
Cystic Fibrosis Foundation
Concluded
2009 - 2011 TargetScreen2 - Novel post-genomics cell-based screens for drug targeting in membrane protein disorders
FP6-2005-LH-7-037365
Researcher
European Union
Concluded
2009/11 - 2010/12 Diagnóstico, Prognóstico e Tratamento da Fibrose Quística.
PIC/IC/83103/2007
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2009 Molecular cloning and functional characterization of members of the novel family of TMEM16 proteins.
SFB 699
Researcher
Deutsche Forschungsgemeinschaft
Concluded
Outputs

Publications

Conference poster
  1. Justin Hean; Imre Mäger; Inna Uliyakina; Joel Z. Nordin; Samir El-Andaloussi; Matthew J. Wood. "Intein mediated enrichment of soluble proteins into exosomes.". Paper presented in ISEV2017 - Annual Meeting, 2017.
    10.1080/20013078.2017.1310414
  2. Loureiro Cláudia; Matos, Ana Margarida; Dias-Alves, Ângela; Joana F. Pereira; Inna Uliyakina; Patrícia Barros; Margarida Sofia Pereira Duarte Amaral; Paulo Matos. "A NHERF1 PDZ domain switch averts CHIP Ub ligase-mediated peripheral membrane quality control of misfolded CFTR.". Paper presented in 14th European Cystic Fibrosis Society Basic Science Conference, 2017.
  3. Ana Margarida Matos; Joana F. Pereira; Inna Uliyakina; Margarida Sofia Pereira Duarte Amaral; Paulo Matos. "Anchoring to the actin-cytoskeleton is not essential to retain functional F508del-CFTR at the plasma membrane.". Paper presented in 12th European Cystic Fibrosis Society Basic Science Conference, 2015.
  4. Hugo Miguel Raposo Correia Botelho; Dahimene S; Inna Uliyakina; Nikhil T. Awatade; Proença MC; Neumann Beate; Christian Tischer; Pepperkok Rainer; Margarida Sofia Pereira Duarte Amaral. "Rescuing F508del-CFTR in airway epithelial cells using a novel traffic-based high content microscopy screening platform". Paper presented in 12th ECFS Basic Science Conference, 2015.
  5. Hugo Miguel Raposo Correia Botelho; Dahimene S; Inna Uliyakina; Neumann Beate; Christian Tischer; Pepperkok Rainer; Margarida Sofia Pereira Duarte Amaral. "A high content screening approach for the identification of CFTR traffic regulators in airway epithelial cells.". Paper presented in ESF/EMBO Cell Polarity and Membrane Trafficking, 2014.
  6. Inna Uliyakina; Ana C Da Paula; Marisa Sousa; Verónica Felício; Sara Afonso; Anabela S. Ramalho; Margarida D. Amaral. "Effect of genetic revertants and small molecules on maturation and function of CFTR without regulatory insertion and regulatory extension.". Paper presented in FEBS congress 2013, 2013.
  7. Hugo Miguel Raposo Correia Botelho; Dahimene S; Inna Uliyakina; Neumann Beate; Christian Tischer; Pepperkok Rainer; Margarida Sofia Pereira Duarte Amaral. "High throughput screen reveals genes regulating wt-CFTR and rescuing F508del-CFTR traffic.". Paper presented in 27th Annual North American Cystic Fibrosis Conference, 2013.
  8. Hugo Miguel Raposo Correia Botelho; Dahimene S; Inna Uliyakina; Neumann Beate; Christian Tischer; Pepperkok Rainer; Margarida Sofia Pereira Duarte Amaral. "Identification of CFTR traffic regulators as a source of novel Cystic Fibrosis therapeutic targets.". Paper presented in The 5th EMBO Meeting, 2013.
  9. Inna Uliyakina; Sousa Marisa; Diana Faria; Yuemin Tian; Marta Palma; Alexis Traynor-Kaplan; Karl Kunzelmann; Margarida Sofia Pereira Duarte Amaral. "Effect of TS-04-95 on Ca2+-activated Cl- conductance on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment.". Paper presented in Cell Biology and Pharmacology of Mendelian Disorders, Italy, 2011.
  10. Inna Uliyakina; Marisa Sousa; Diana Faria; Yuemin Tian; Marta Palma; Alexis Traynor-Kaplan; Karl Kunzelmann; Margarida Sofia Pereira Duarte Amaral. "Effect of TS-04-95 on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment.". Paper presented in European Cystic Fibrosis Society (ECFS) Basic Conference, 2010.
Journal article
  1. Inna Uliyakina; Hugo M. Botelho; Ana C. da Paula; Sara Afonso; Miguel J. Lobo; Verónica Felício; Carlos M. Farinha; Margarida D. Amaral. "Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions". International Journal of Molecular Sciences 21 12 (2020): 4524-4524. https://doi.org/10.3390/ijms21124524.
    10.3390/ijms21124524
  2. Daniel V. Olivença; Inna Uliyakina; Luis L. Fonseca; Margarida D. Amaral; Eberhard O. Voit; Francisco R. Pinto. "A Mathematical Model of the Phosphoinositide Pathway". Scientific Reports 8 1 (2018): https://doi.org/10.1038%2Fs41598-018-22226-8.
    10.1038/s41598-018-22226-8
  3. Carlos M. Farinha; Marisa Sousa; Sara Canato; André Schmidt; Inna Uliyakina; Margarida D. Amaral. "Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR". Pharmacology Research & Perspectives 3 4 (2015): e00152-e00152. https://doi.org/10.1002%2Fprp2.152.
    10.1002/prp2.152
  4. Cláudia A. Loureiro; Ana Margarida Matos; Ângela Dias-Alves; Joana F. Pereira; Inna Uliyakina; Patrícia Barros; Margarida D. Amaral; Paulo Matos. "A molecular switch in the scaffold NHERF1 enables misfolded CFTR to evade the peripheral quality control checkpoint". Science Signaling 8 377 (2015): ra48-ra48. https://doi.org/10.1126%2Fscisignal.aaa1580.
    10.1126/scisignal.aaa1580
  5. Hugo M. Botelho; Inna Uliyakina; Nikhil T. Awatade; Maria C. Proença; Christian Tischer; Lalida Sirianant; Karl Kunzelmann; Rainer Pepperkok; Margarida D. Amaral. "Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery". Scientific Reports 5 1 (2015): https://doi.org/10.1038%2Fsrep09038.
    10.1038/srep09038
  6. Nikhil T. Awatade; Inna Uliyakina; Carlos M. Farinha; Luka A. Clarke; Karina Mendes; Amparo Solé; Juan Pastor; Maria Margarida Ramos; Margarida D. Amaral. "Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis". EBioMedicine 2 2 (2015): 147-153. https://doi.org/10.1016%2Fj.ebiom.2014.12.005.
    10.1016/j.ebiom.2014.12.005
  7. Joana Almaça; Diana Faria; Marisa Sousa; Inna Uliyakina; Christian Conrad; Lalida Sirianant; Luka A. Clarke; et al. "High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets". Cell 154 6 (2013): 1390-1400. https://doi.org/10.1016%2Fj.cell.2013.08.045.
    10.1016/j.cell.2013.08.045
  8. Marisa Sousa; Maria F. Servidoni; Adriana M. Vinagre; Anabela S. Ramalho; Luciana C. Bonadia; Verónica Felício; Maria A. Ribeiro; et al. "Measurements of CFTR-Mediated Cl- Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis". PLoS ONE 7 10 (2012): e47708-e47708. https://doi.org/10.1371%2Fjournal.pone.0047708.
    10.1371/journal.pone.0047708
  9. Yuemin Tian; Rainer Schreiber; Podchanart Wanitchakool; Patthara Kongsuphol; Marisa Sousa; Inna Uliyakina; Marta Palma; et al. "Control of TMEM16A by INO-4995 and other inositolphosphates". British Journal of Pharmacology 168 1 (2012): 253-265. https://doi.org/10.1111%2Fj.1476-5381.2012.02193.x.
    10.1111/j.1476-5381.2012.02193.x
  10. Alexandre Gonçalves; Patrícia Poeta; Nuno Silva; Carlos Araújo; Maria López; Elena Ruiz; Inna Uliyakina; et al. "Characterization of Vancomycin-Resistant Enterococci Isolated from Fecal Samples of Ostriches by Molecular Methods". Foodborne Pathogens and Disease 7 9 (2010): 1133-1136. https://doi.org/10.1089%2Ffpd.2010.0548.
    10.1089/fpd.2010.0548
  11. Catarina Carneiro; Carlos Araújo; Alexandre Gonçalves; Laura Vinué; Sergio Somalo; Elena Ruiz; Inna Uliyakina; et al. "Detection of CTX-M-14 and TEM-52 Extended-Spectrum Beta-Lactamases in FecalEscherichia coliIsolates of Captive Ostrich in Portugal". Foodborne Pathogens and Disease 7 8 (2010): 991-994. https://doi.org/10.1089%2Ffpd.2009.0494.
    10.1089/fpd.2009.0494
  12. Schreiber, R.; Uliyakina, I.; Kongsuphol, P.; Warth, R.; Mirza, M.; Martins, J.R.; Kunzelmann, K.; et al. "Expression and function of epithelial anoctamins". Journal of Biological Chemistry 285 10 (2010): 7838-7845. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951235116&partnerID=MN8TOARS.
    10.1074/jbc.M109.065367
Thesis / Dissertation
  1. Uliyakina, Inna, 1985-. "Analysis of CFTR mutants in epithelial cells/tissues and testing of CFTR-repairing therapies". PhD, 2015. http://hdl.handle.net/10451/20232.

Other

Other output
  1. GAPDH controls extracellular vesicle biogenesis and enhances therapeutic potential of EVs in silencing the Huntingtin gene in mice via siRNA delivery. A novel role for GAPDH in EV biogenesis. The presence of free GAPDH binding sites on EVs can be effectively exploited to substantially enhance the therapeutic potential of EV-mediated drug delivery to the brain.. 2020. Ghulam Hassan Dar; Cláudia C. Mendes; Wei-Li Kuan; Mariana Conceição; Inna Uliyakina; Miguel J Lobo; Samir El-Andaloussi; et al. https://www.biorxiv.org/content/10.1101/2020.01.09.899880v1.
    doi.org/10.1101/2020.01.09.899880
  2. Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators can be Achieved by Removal of Two Unique Regulatory Regions. Role of regulatory extension on CFTR stability. 2018. Inna Uliyakina; Ana C Da Paula; Sara Afonso; Miguel J Lobo; Verónica Felício; Hugo M Botelho; Carlos M Farinha; Margarida D Amaral. https://doi.org/10.1101/320630.
    10.1101/320630
  3. A Mathematical Model of the Phosphoinositide Pathway. 2017. Daniel Vigário Olivença; Inna Uliyakina; Luis L. Fonseca; Margarida Amaral; Eberhard Voit; Francisco Rodrigues Pinto. https://doi.org/10.1101%2F182634.
    10.1101/182634
  4. High throughput screen reveals genes regulating wt-CFTR and rescuing F508del-CFTR traffic.. 2013. Hugo Miguel Raposo Correia Botelho; Dahimene S; Inna Uliyakina; Neumann Beate; Christian Tischer; Pepperkok Rainer; Amaral, Margarida. https://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.22898.
  5. Understanding rescue of F508del-CFTR variants without the regulatory extension (dRE) and regulatory insertion (dRI) by genetic revertants and chemical modulators.. 2012. Inna Uliyakina; Ana C Da Paula; Ramalho Anabela S; Margarida Sofia Pereira Duarte Amaral. https://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.22682.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/11/26 Exploring the impact of Staphylococcus aureus on Cystic Fibrosis epithelial cell inflammation, differentiation and epithelial repair. BioISI Day
BioISI
2018/01/30 Exploring novel therapeutic strategies for genetic disorders. DPAG Postdoctoral Meeting, University of Oxford
DPAG, University of Oxford
2017/09/19 EV mediated delivery of NPC1 protein restores cellular cholesterol transport. EVOX Therapeutics Meeting
(Oxford, United Kingdom)
2017/05/18 Exosome-mediated delivery of CFTR protein to Human Bronchial Epithelia as a novel therapeutic strategy to treat Cystic Fibrosis. ISEV2017 - Annual Meeting
ISEV (Toronto, Canada)
2016/04 Exosome-mediated delivery of ABC transporters to treat genetic diseases including Cystic Fibrosis and Tangier’s disease. University of Oxford - Karolinska Institute exosome joint meeting
Karolinska Institute
2013/06 Rescue of F508del-CFTR without the regulatory insertion (¿RI) and regulatory extension (¿RE) in combination with genetic revertants and small molecules. 36th European Cystic Fibrosis Society Conference
(Lisboa, Portugal)
2013/04/04 Functional validation of Cystic Fibrosis modifier genes identified by GWAS by high-throughput siRNA microscopy-based assays. BioISI Research Semminars
(LIsboa, Portugal)
2012/10 Understanding Rescue of F508del-CFTR Variants Without the Regulatory Extension (¿RE) and Regulatory Insertion (¿RI) by Genetic Revertants and Chemical Modulators. 26th Annual North American Cystic Fibrosis Conference
(Orlando, United States)
2011/10 Effect of TS-04-95 on Ca2+-activated Cl- conductance on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment. Cell Biology and Pharmacology of Mendelian Disorders
(Italy)
2011/06 Therapeutic strategy to correct ion transport defects: effect of TS-04-95 on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment. Ciência QB – 1st Annual Meeting of FCUL PhD Students
(Lisbon, Portugal)
2010/04 Effect of TS-04-95 on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment. European Cystic Fibrosis Society Basic Conference
ECFS (Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016 - Current Oxfordshire Science Festival 2016 (2016 - 2016)
Festival (Member of the Organising Committee)
2017 - 2017 Oxfordshire Science Festival 2017 (2017 - 2017)
Festival (Member of the Organising Committee)
2017 - 2017 Through the Looking Glass (2017 - 2017)
Exhibition (Member of the Organising Committee)
2017 - 2017 Fundraising event Town and Gown for Muscular Dystrophy UK 2017 (2017 - 2017)
Other (Other)
2016 - 2016 Fundraising event Town and Gown for Muscular Dystrophy UK 2016 (2016 - 2016)
Other
2015 - 2015 European Researcher´s Night (2015)
Other (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2013/06 - 2013/06 36th European Cystic Fibrosis Conference (2013/06 - 2013/06)
Conference (Member of the Organising Committee)
 European Cystic Fibrosis Society, Denmark
2012/05/02 - 2012/05/02 Open Day at DQB, FCUL, Portugal (2012/05/02 - 2012/05/02)
Exhibition (Other)
 Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/02/09 - Current EuChemS @Global Women’s Breakfast. IUPAC.
Meeting
 Global Women’s Breakfast.
International Union of Pure and Applied Chemistry, United States
2020/11/26 - Current BioISI Day 2020
Meeting
 BioISI Day
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2020/11/25 - Current How are vaccines developed, approved and produced? AICIB, EATRI, PtCRIN Joint initiative. Science talks.
Workshop
 How are vaccines developed, approved and produced?
2020/02/13 - Current 2º Encontro do Mestrado em Bioquímica, FCUL
Round table
 2º Encontro do Mestrado em Bioquímica.
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/02/12 - Current Building Bonds to Create Future Leaders: global women’s breakfast. International Union of Pure and Applied Chemistry.
Meeting
 Building Bonds to Create Future Leaders: global women’s breakfast
International Union of Pure and Applied Chemistry, United States
2020/12/09 - 2020/12/11 International Conference on Cell and Experimental Biology.
Conference
 International Conference on Cell and Experimental Biology.
2018/04/22 - 2018/04/26 Keystone Symposia on "Selective Autophagy"
Symposium
 Keystone Symposia on "Selective Autophagy", Kyoto, Japan
Keystone Symposia, United States
2017/12/12 - 2017/12/12 UK-EV Annual Forum- 2017, Birmingham, UK
Conference
 UK-EV Annual Forum- 2017, Birmingham, UK
UK Society for Extracellular Vesicles, United Kingdom
2017/09/22 - 2017/09/24 Niemann-Pick UK 24th Annual Family Conference & Interactive Workshop 2017
Conference
 Niemann-Pick UK Annual Family Conference & Interactive Workshop 2017
2017/06/21 - 2017/06/21 Careers Conference for Researchers 2017, University of Oxford
Conference
 Careers Conference for Researchers 2017, University of Oxford
2017/05/18 - 2017/05/21 ISEV2017 - Annual Meeting, Toronto, Canada
Conference
 ISEV2017 - Annual Meeting, Toronto, Canada
International Society for Extracellular Vesicles, United States
2017/05/11 - 2017/05/12 Oxford Rare Disease Conference 2017
Conference
 Oxford Rare Disease Conference 2017
2017 - 2017 eLife Journal editors providing hands-on Peer Review
Workshop
 eLife Journal Peer Review Workshop
Universidade de Oxford - Departamento de Fisiologia, Anatomia e Genética, United Kingdom
2017 - 2017 Oxosome - The Oxford Extracellular Vesicle Group - Annual Meeting, Oxford 2017
Meeting
 Oxosome - The Oxford Extracellular Vesicle Group - Annual Meeting, Oxford 2017
2017 - 2017 Micron Advanced Microscopy Course 2017, University of Oxford
Workshop
 Micron Advanced Microscopy Course 2017, University of Oxford
University of Oxford Department of Biochemistry, United Kingdom
2016/05/04 - 2016/05/07 ISEV2016 - Annual Meeting, Rotterdam, The Netherlands
Conference
 ISEV2016 - Annual Meeting, Rotterdam, The Netherlands
International Society for Extracellular Vesicles, United States
2016 - 2016 Presentation Skills Workshop
Workshop
 Presentation Skills
University of Oxford Humanities Division, United Kingdom
2016 - 2016 Oxosome - The Oxford Extracellular Vesicle Group - Annual Meeting, Oxford 2016
Meeting
 Oxosome - The Oxford Extracellular Vesicle Group - Annual Meeting, Oxford 2017
2014/10/20 - 2014/10/26 High Throughput Microscopy for Systems Biology
Workshop
 EMBO Practical Course, EMBL Advanced Training Centre
EMBO Press, Germany
2013/04/15 - 2013/04/19 Basics in Super-Resolution Microscopy
Workshop
 Basics in Super-Resolution Microscopy
European Molecular Biology Laboratory - Advanced Light Microscopy Facility, Germany
2013/02/18 - 2013/02/21 Basics in Confocal Microscopy
Workshop
 Basics in Confocal Microscopy
European Molecular Biology Laboratory - Advanced Light Microscopy Facility, Germany
2013/01/28 - 2013/01/31 Basics in Light Microscopy (widefield)
Workshop
 Basics in Light Microscopy (widefield)
European Molecular Biology Laboratory - Advanced Light Microscopy Facility, Germany
2012/10/01 - 2012/10/05 Advanced Imaging Techniques, EMBL
Workshop
 Advanced Imaging Techniques, EMBL
European Molecular Biology Laboratory, Germany
2012/07/26 - 2012/07/26 siRNA Design Course, ALMF, EMBL
Workshop
 siRNA Design Course, ALMF, EMBL
European Molecular Biology Laboratory - Advanced Light Microscopy Facility, Germany
2011/10/07 - 2011/10/11 FEBS Worshop on “Cell Biology and Pharmacology of Mendelian Disorders”
Workshop
 FEBS Worshop on “Cell Biology and Pharmacology of Mendelian Disorders”
Federation of European Biochemical Societies, United Kingdom

Consulting

Activity description Institution / Organization
2017/01/01 - 2018/11/01 Provision of advice and assistance with regulatory documentation and filings to apply for IND/CTA to use exosomes as a treatment for lysosomal storage disorders. Elaboration of a research project that contributed to raise £35.5 million in series B financing by Evox Therapeutics. EVOX Therapeutics , United Kingdom

Oxford University Innovation, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/11/20 - 2014/11/26 Time-lapse image acquisition of living cells using Olympus wide-field ScanR microscope. EMBO Practical Course, High Throughput Microscopy for Systems Biology, EMBL Advanced Training Centre, Heidelberg, Germany High Throughput Microscopy for Systems Biology EMBO Press, Germany
2014/04/07 - 2014/04/11 Functional Genomics. Advanced Light Microscopy. BioSyS PhD Programme in Biology/Biochemistry, BioISI, Lisbon, Portugal BioSyS PhD Programme in Biology/Biochemistry (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2014/02/03 - 2014/02/07 Signalling, Differentiation and Physiology. BioSyS PhD Programme in Biology/Biochemistry, BioISI, Lisbon, Portugal BioSyS PhD Programme in Biology/Biochemistry (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2013/10/21 - 2013/10/25 High Content Screening in Cystic Fibrosis Biomedical Research. Cell Biology Module, Predoc Course 2013, EMBL, Heidelberg, Germany Predoc Course 2013 (Doktor (PhD)) European Molecular Biology Laboratory, Germany
2011/09/19 - 2011/09/23 Epithelial Cell Differentiation, Cilia and Physiology. Molecular and Cellular Biology of the Epithelium in Health and Disease. FCUL, Lisbon, Portugal Molecular and Cellular Biology of the Epithelium in Health and Disease. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
Distinctions

Award

2020 10.000€ award for exploratory project "Exploring the impact of S. aureus on human Cystic Fibrosis epithelial cell inflammation, epithelial differentiation and repair".
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017 £150.000 award for proof of concept study “Extracellular vesicles-mediated delivery of proteins to treat Lysosomal Storage-related disorders”.
EVOX Therapeutics , United Kingdom
2013 Student Helper Award, European Cystic Fibrosis Conference (ECFC 2013), Lisbon, Portugal
European Cystic Fibrosis Society, Denmark
2013 Youth Travel Fund grant for the 13th Young Scientists' Forum and 38th FEBS congress in St. Petersburg, Russian Federation
Federation of European Biochemical Societies, United Kingdom
2013 Pfizer Prize: Basic Research 2013 (with the publication: Almaça J, Faria D, Sousa M, Uliyakina I et al. High-Content siRNA Screen Reveals Global ENaC Regulators and Potential Cystic Fibrosis Therapy Targets. 2013, Cell 154(6):1390-1400.)
Pfizer Portugal, Portugal
2012 Stipend for overseas presentations, North American Cystic Fibrosis Conference (NACFC), Orlando, Florida, USA
Cystic Fibrosis Foundation, United States
2011 Youth Travel Fund grant for the Cell Biology and Farmacology of Mendelian Disorders Workshop, Vico Equense, Italy
Federation of European Biochemical Societies, United Kingdom
2010 Student Helper Award – New Frontiers in Basic Science of Cystic Fibrosis Conference, Carcavelos, Portugal
European Cystic Fibrosis Society, Denmark
2010 4-year FCT PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal