Bruno Miguel Rodrigues Neves (7D1E-5EFB-7234)

Curriculum Vitae

Bruno Miguel Rodrigues Neves

Bruno Neves (BN) earned his degree in Pharmaceutical Sciences from the University of Coimbra in 2006 and subsequently pursued a Ph.D. in Molecular and Cellular Biology at the Centre for Neurosciences and Cell Biology, University of Coimbra, and the Innate Immunity and Inflammation Unit, Instituto de Biologia y Genética Molecular, University of Valladolid, Spain, completing it in 2011. From 2011 to 2018, BN served as an invited professor at the Chemistry Department of the University of Aveiro and the Faculty of Pharmacy at the University of Coimbra. Since 2018, BN held the position of Assistant Professor and Director of the Biomedical Sciences degree at the Medical Sciences Department of the University of Aveiro. From the same date, he is a Principal Investigator and member of the Scientific Board at the Institute of Biomedicine (iBiMED). During his Ph.D, BN made significant contributions to the field of Dendritic Cell (DCs) immunobiology by unraveling the molecular mechanisms by which haptens and pathogen/danger associated molecular patterns trigger DC activation. These pioneering findings allowed the development of novel dendritic cell-based in vitro test for identifying haptens in the cosmetic and chemistry industries. This achievement resulted in an international patent (WO/2012/148297) and the establishment of a start-up company, Toxfinder Lda, where BN serve as the co-founder and CEO. BN scientific and entrepreneurial endeavors have been recognized with several prizes, including the Bolsa de Ignição INOV.Capital, Caixa de Crédito Agricola Award for innovation and entrepreneurship, and the COTEC Idea to Product Portugal Competition. Throughout his scientific journey, BN have played key roles in coordinating or participating as a team member in 22 national and international R&D projects allowing him to secure the mentorship of 2 post-doctoral researchers, 10 Ph.D. students (with 6 ongoing), 28 M.Sc. students (with 4 ongoing), and 19 B.Sc. students. BN authored 8 book chapters and published over 70 peer-reviewed manuscripts in journals such as Journal for Immunotherapy of Cancer, American Journal of Pathology, Small, Advanced Functional Materials, Pharmacological Research, and Frontiers in Immunology, accumulating over 5600 citations, and achieving an h-index of 23 (Scopus). The scientific findings generated within these works led to 3 international patents (WO/2024/013711, WO/2023/148531 and WO/2012/148297) and 1 international patent application (P1303-7WO). Currently, BN primary focus is on developing innovative antitumor immunotherapeutic strategies and understanding how danger sensing mechanisms and stress responses are integrated into innate immune cells. He is actively engaged in translational research and have collaborated extensively with a leading national pharmaceutical company, Tecnimede Pharmaceutical Group, in the establishment of a pilot-scale facility to produce clinical grade cellular products (UpCells). Within the framework of this collaboration, BN is spearheading the coordination of the development of a next-generation DC-based vaccine for pancreatic and pulmonary tumors. BN is actively involved as a referee for several leading journals in the field of Biomedicine and as an Expert Evaluator for institutions such as the Dutch Cancer Society (KWF), Portuguese National Agency for Innovation and Wellcome Trust.

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Identification

Personal identification

Full name: Bruno Miguel Rodrigues Neves

Citation names

Neves, Bruno

Author identifiers

Ciência ID: 7D1E-5EFB-7234
ORCID iD: 0000-0001-7391-3124
Researcher Id: L-2557-2016
Scopus Author Id: 21734628100

Email addresses

bruno.neves@ua.pt (Professional)

Addresses

University of Aveiro. Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Agra do Crasto - edifício 30, 3810-193 A, Aveiro, Aveiro, Portugal (Professional)

Websites

https://www.ua.pt/pt/ibimed/page/19438 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
French	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)

Education

	Degree	Classification
2011/01/11 Concluded	Farmácia (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal "Dendritic cell modulation by allergenic and infectious stimuli" (THESIS/DISSERTATION)	Approved with Distinction and Praise by unanimity
2006 Concluded	Licenciatura pré-Bolonha (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal "n/a" (THESIS/DISSERTATION)	16/20
2001 Concluded	ciências (Ensino secundário) Agrupamento Escolas da Mealhada, Portugal "n/a" (THESIS/DISSERTATION)	18.4/20

Affiliation

Science

	Category Host institution	Employer
2018/03 - Current	Principal Investigator (Research)	Universidade de Aveiro Instituto de Biomedicina, Portugal

2014/09/01 - 2018	Researcher (Research)	CNC.IBILI, Portugal

2011/09/01 - 2015/08/31	Researcher (Research)	Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2024/08/15 - Current	Associate Professor (University Teacher)	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/04/15 - 2024/08/14	Assistant Professor (University Teacher)	Universidade de Aveiro Departamento de Ciências Médicas, Portugal

2014 - 2018/02/01	Invited Assistant Professor (University Teacher)	Universidade de Coimbra Faculdade de Farmácia, Portugal

2011/09/01 - 2015/08/31	Invited Assistant Professor (University Teacher)	Universidade de Aveiro Departamento de Química, Portugal

Positions / Appointments

	Category Host institution	Employer
2018/10/17 - 2024/09/01	Director of the Biomedical Science degree	Universidade de Aveiro Departamento de Ciências Médicas, Portugal

Others

	Category Host institution	Employer
2011/09/01 - Current	Founder and CEO	Toxfinder Lda, Portugal

2007/01/01 - 2011/01/11	PhD Student	CNC.IBILI, Portugal

2006/05/02 - 2006/12/31	Curricular Traineeship	CNC.IBILI, Portugal

2006/03/01 - 2006/05/01	Curricular Traineeship	Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Projects

Grant

	Designation	Funders
2021/01/04 - Current	Dissecting the mechanism by which haptens disrupt lysosomes and activate NLRP3 inflammasome: the missing link in chemical allergic reactions physiopathology EPIC-XS project 265 Principal investigator Universidade de Aveiro Instituto de Biomedicina, Portugal	Horizon 2020 European Innovation Council Fast Track to Innovation Ongoing
2020/01/06 - 2020/03/31	Development of a new medical device for prevention of allergic contact dermatitis PD/BDE/142926/2018 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT Ongoing
2014 - 2015	Exosomes: putative biomarkers for respiratory and cutaneous allergens hazard grant agreement number 262067 Researcher	European Commission Seventh Framework Programme for Research and Technological Development Joint Technology Initiatives Concluded
2014 - 2015	Generation of a novel dendritic cell-based vaccine against glioblastoma INOV.C Researcher	Universidade de Coimbra

Contract

	Designation	Funders
2018/08/06 - Current	Cellular immunotherapy targeting cancer stem cells ImmunoDCs@CancerStemCells Principal investigator Toxfinder Lda, Portugal	Grupo Tecnimede Ongoing
2018 - Current	Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer) Cosmetics Europe Principal investigator Toxfinder Lda, Portugal	Cosmetics Europe Concluded
2023/03/06 - 2026/03/05	Transient pluripotent states as novel reservoirs of cancer-specific antigens 2022.01199.PTDC Researcher Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022 - 2023	Improving the manufacturing of mRNA vaccines applying ionic liquids and integrated production-clarification processe EXPL/BII-BTI/0731/2021 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2021 - 2022	The role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer. PTDC/BTM-TEC/28534/2017 Researcher	Concluded
2020/10/15 - 2021/10/14	SIARC- Integrated High Speed Tracking Automation Solutions fo COVID-19 CENTRO-O1-02B7-FEDER-069749 Researcher	European Regional Development Fund Concluded
2018 - 2020/12/31	PAGE - Protein aggregation throughout life CENTRO-01-0145-FEDER-000003 Researcher Universidade de Aveiro Instituto de Biomedicina, Portugal	European Regional Development Fund Concluded
2019 - 2020	N2BD- Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development CENTRO-01-0145-FEDER-030752 Researcher	Associação para a Inovação e Desenvolvimento da FCT Concluded
2019/01/01 - 2019/12/31	Química Orgânica, Produtos Naturais e Agroalimentares UID/QUI/00062/2019 Universidade de Aveiro, Portugal Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/06 - 2019/12	4Epilepsy- Promoting the quality of life of epileptic patients through personalized medicine PTDC/SAU-SER/30478/2017 Researcher	Associação para a Inovação e Desenvolvimento da FCT Concluded
2018 - 2019	Allergens4AD-Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease PTDC/MED-FAR/29369/2017 Researcher	Associação para a Inovação e Desenvolvimento da FCT Concluded
2018 - 2019	Giardia lamblia extracellular vesicles in modulation of host immune cells: potential application of Giardia EVs against intestinal inflammation PTDC/SAU-PAR/31506/2017 Researcher	Associação para a Inovação e Desenvolvimento da FCT Concluded
2014 - 2017	In chemico, in silico and in vitro dendritic cell modeling to predict human respiratory allergens 2014-07 Researcher	Johns Hopkins University Center for Alternatives to Animal Testing Concluded
2014 - 2016	Development and validation of a pilot laboratory for cell therapy (UpCells) 5378/2014 Researcher Grupo Tecnimede, Portugal Universidade de Coimbra, Portugal	Agência Nacional de Inovação SA Concluded
2014 - 2015/06	ToxVitroTesting: Replacement of in vivo toxicity tests by equivalent in vitro tests ToxVitroTesting 38977/2014 Principal investigator	Agência Nacional de Inovação SA Concluded
2010/05/01 - 2013/10/31	Mecanismo e propriedades anti-inflamatórias de plantas medicinais: investigação multidisciplinar para a sua validação e utilização como fonte de fitofármacos PTDC/SAU-FCF/105429/2008 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Aveiro, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	In vitro alternative approach for chemical skin sensitization hazard: an EU legislation demand PTDC/SAU-OSM/099762/2008 PhD Student Fellow	Associação para a Inovação e Desenvolvimento da FCT
2009 - 2013	Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals FCT PTDC/SAU-FCF/105429/2008 PhD Student Fellow	Associação para a Inovação e Desenvolvimento da FCT
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2006 - 2010	ROLE OF DENDRITIC CELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuated parasite Leismania infantum FCT PTDC/SAU-FCF/67351/2006 PhD Student Fellow	Associação para a Inovação e Desenvolvimento da FCT
2007/08/16 - 2009/12/31	PAPEL DAS CÉLULAS DENDRITICAS NA LEISHMANIOSE: estudos de sinalização intracelular na infecção pelo parasita Leismania infantum virulento ou atenuado. PTDC/SAU-FCF/67351/2006 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Neves, Bruno M.; Almeida, Catarina R.. "Signaling Pathways Governing Activation of Innate Immune Cells". In Tissue-Specific Cell Signaling, 93-131. Springer International Publishing, 2020. 10.1007/978-3-030-44436-5_4 Neves, Bruno. "Metabolismo do tecido conjuntivo: A diversidade metabólica dos elementos figurados do sangue.". In Bioquímica Fisiológica: Integração do Metabolismo na Especialização dos Órgãos.. Portugal: Afrontamento, 2020. Published Calmeiro, João; Carrascal, Mylene; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; Neves, Bruno Miguel. "Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy". In Dendritic Cells. InTech, 2018. 10.5772/intechopen.78804 Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Antiinflammatory Activity of Polyphenols on Dendritic Cells". In Polyphenols: Prevention and Treatment of Human Disease (second edition), 395-415. Elsevier, 2018. 10.1016/b978-0-12-813008-7.00031-x Neves, Bruno Miguel; Martins, João Demétrio; Ferreira, Isabel; Silva, Ana; Cruz, Maria Teresa. "In Vitro Dendritic Cell-Based Test for Skin Sensitizers Identification and Potency Estimation". In Alternatives for Dermal Toxicity Testing, 417-435. Springer International Publishing, 2017. 10.1007/978-3-319-50353-0_29 Neves, Bruno. "Anti-Inflammatory Activity of the Honeybee Plant- Derived Products Honey, Pollen and Propolis". In Chemistry, Biology and Potential Applications of Honeybee Plant- Derived Products, 313-346. BENTHAM SCIENCE PUBLISHERS, 2016. 10.2174/9781681082370116010012 Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Anti-Inflammatory Activity of Polyphenols on Dendritic Cells". In Polyphenols in Human Health and Disease, 373-392. Elsevier, 2014. 10.1016/b978-0-12-398456-2.00028-1 Miguel, Bruno; Celeste, Maria; Teresa, Maria. "Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View". In Protein Kinases. InTech, 2012. 10.5772/37771
Conference abstract	Neves, Bruno. "Unveiling new molecules with preventive properties for the management of allergic contact dermatitis". Paper presented in ESCD CONGRESS 2022, 2022. Published Cátia Sousa; Neves, Bruno; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira. ""JNK1 inhibition contributes to the antiinflammatory activity of (R)-(-)-carvone"". Paper presented in 52nd Annual Meeting of the Portuguese Society of Pharmacology, Porto, 2022. Neves, Bruno. "Prevention of allergic contact dermatitis, myth or reality? Avoiding contact allergens: from basic research to development of a new medical device". Paper presented in EUROTOX 2021, Copenhagen, 2021. Neves, Bruno. "Dendritic-cell based immunotherapy targeting pancreatic and NSCLC cancer stem cells". Paper presented in iTOC7 - The 7th Leading International Cancer Immunotherapy Conference in Europe, 2020. Published Neves, Bruno. "The role of endoplasmic reticulum stress in the innate immune system in bipolar disorder". Paper presented in 27th European Congress of Psychiatry, Warsaw, 2019. Published Neves, Bruno. "Development of a novel dendritic cell-based immunotherapy targeting cancer stem cells". Paper presented in 2019 ASCO Annual Meeting, Chicago, 2019. Published Neves, Bruno. "Impact of different GMP media in the production of dendritic cells for next-generation cancer immunotherapy: Functional and metabolic characterization". Paper presented in ESMO Immuno-Oncology Congress, Geneve, 2018. Published Neves, Bruno. "Respiratory and skin allergies: a matter of differential ROS origin and kinetics?". Paper presented in 14th Congress of the European Society of Contact Dermatitis (ESCD), 18–20 October 2018, Milan, Italy, Milan, 2018. Published • 10.1111/cod.13111 Sousa, Cátia; Neves, Bruno; Cavaleiro, Carlos; Leitão, Alcino Jorge; Mendes, Alexandrina Ferreira. "Systematic screening of anti-inflammatory properties and structure activity relationship of p-menthane derivatives". Paper presented in XLVII Annual Meeting of the Portuguese Society of Pharmacology, Coimbra, 2017. Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in 2nd European Congress of Immunology, Berlim, 2009. Published
Conference paper	Francisca P. Correia; Patrícia Pinto Pinho; Renato Silva; Luísa Helguero; Maria Lourdes Pereira; Bruno Neves; Margarida Fardilha. "Enhancing Learning in Biomedicine through Research-based Learning: Empowering Students for Future Success". 2024. 10.4995/HEAd24.2024.17308
Conference poster	Faria, Clarissa Perez; Ferreira, Bárbara; Ágata Lourenço; Mateus, Daniela; Sebastião, Ana Isabel; Neves, Bruno; Cruz, Maria Teresa; Maria do Céu Rodrigues de Sousa. Corresponding author: Maria do Céu Rodrigues de Sousa. "Extracellular Vesicles of Giardia lamblia modulate host cell innate immunity: new avenues for the exploitation of novel therapies". Paper presented in 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2023. Conde, Tiago A.; Bruna Filipa Brito Neves; Couto, Daniela; Tânia Sofia Rodrigues de Melo; Margarida Costa; Joana Silva; Neves, Bruno; Domingues, Pedro; Domingues, Maria Rosário. "Evaluation of microalgae fatty acids and antioxidant activity contribute to the valorization of these microorganisms as biofactories of healthy lipids". Paper presented in 16th GERLI International Lipidomics Meeting, 2021. Conde, Tiago A.; Couto, Daniela; Melo, Tânia; Moreira, Ana S.P.; Costa, Margarida; Silva, Joana; Neves, Bruno; Domingues, Pedro; Domingues, M. Rosário. "Production of green, sustainable and healthy polar lipid extracts of Chlorococcum amblystomatis using ultrasound-assisted extraction". 2021. Bruna Filipa Brito Neves; Conde, Tiago A.; Couto, Daniela; Tânia Sofia Rodrigues de Melo; Neves, Bruno; Margarida Costa; Joana Silva; Domingues, Pedro; Domingues, Maria Rosário. "Screening of specific fatty acid signatures of microalgae towards valorization of sustainable and healthy lipids". Paper presented in Lipids in the Ocean, 2021. Silva, Ana Cristina Rosa da; Pereira, Marta; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER¿S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cell plasticity in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in human-monocyte-derived DCs". Paper presented in 1st Meeting of the French Society of Cancer Immunotherapy, Institut Curie, Paris, France, 2019. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019. Brites, G; Silva, Filipa; Ferreira, Isabel; Silva, Ana; Carrascal, Mylene; Neves, Bruno; Rosete, Teresa. "Managing allergic contact dermatitis: screening of molecules with potential for preventing the disease". Paper presented in 24th World Congress of Dermatology, 2019. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Impact of different GMP serum-free media in the plasticity of dendritic cells for clinical use in cancer immunotherapy". Paper presented in 26th Porto Cancer Meeting & Porto-Bordeaux joint meeting: the cancer ecosystem, i3S ¿ Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2019. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cells plasticity for clinical use in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in monocyte-derived dendritic cells.". Paper presented in 5th Workshop on Dendritic Cell Biology: antitumoral immunotherapy, from biology to the clinic. Champalimaud Foundation, Lisbon, Portugal, 2019. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Morais, S; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Mitochondria-Associated Membranes: the putative link between cellular stress and inflammasome activation in Bipolar Disorder". Paper presented in Encontro Nacional da Sociedade Portuguesa de Psiquiatria e Saúde Mental (SPPSM)\| II Encontro das Secções, 2019. Pereira, Marta; Silva, Ana; Neves, Bruno; Moreira, Patricia; Silva, Maria Manuel; Santos, Armanda Emanuela; Pereira, Cláudia Fragão; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer¿s disease". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, Portugal, 2019. Silva, Ana Cristina Rosa da; Pereira, Marta; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, MMC; et al. "Skin allergens and Alzheimer´s disease: preliminar studies on na (im)probable link". Paper presented in . 8th ECS workshop Calcium Signalin in Aging and Neurodegenerative Diseases, 2019. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Resposta ao stresse celular em células do sistema imune inato na doença Bipolar". Paper presented in 2º Semina´rio da Sociedade Portuguesa para o Estudo da Saúde Mental - SPESM, 2018. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Cruz, Maria Teresa; Pereira, Cláudia. "Role of Mitochondria-Associated Membranes in the endoplasmic reticulum stress response in the innate immune system". Paper presented in MitoPorto International Symposium, 2018. Resende, Mariana; Moreira, Diana; Cunha, Joana; Augusto, J; Neves, Bruno; Cruz, Maria Teresa; Estaquier, Jerôme; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in 3rd I3S Scientific Retreat, 2012. Resende, Mariana; Moreira, Diana; Cunha, Joana; Neves, Bruno; Costa-Lima, Sofia; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Infected but not Bystander Dendritic Cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in XXXVII Annual Meeting of the Portuguese Society for Immunology, 2011. Resende, Mariana; Silvestre, Ricardo; Neves, Bruno; Cunha, Joana; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Differential effect of Leishmania infantum on infected and bystander dendritic cells". Paper presented in XXXVI Annual Meeting of the Portuguese Society for Immunology, 2010. Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Poster PA11/60 Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in European Congress of Immunology 2009, 2009.
Journal article	Gonçalo S. Brites; Isabel Ferreira; Ana I. Sebastião; Cátia Sousa; Ana Silva; Mylene Carrascal; Rui C. Oliveira; et al. "Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel". Journal of Pharmaceutical Analysis (2024): https://doi.org/10.1016/j.jpha.2024.101071. 10.1016/j.jpha.2024.101071 Ana Carolina Pinto; Patrícia Tavares; Bruno Neves; Pedro F. Oliveira; Rui Vitorino; Daniel Moreira-Gonçalves; Rita Ferreira. "Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions". Journal of Molecular Medicine (2024): https://doi.org/10.1007/s00109-024-02427-7. 10.1007/s00109-024-02427-7 Antoine S. Almeida; Bruno M. Neves; Regina M.B.O. Duarte. "Contribution of water-soluble extracts to the oxidative and inflammatory effects of atmospheric aerosols: A critical review". Environmental Pollution (2024): https://doi.org/10.1016/j.envpol.2023.123121. 10.1016/j.envpol.2023.123121 Tiago Conde; Bruno Neves; Daniela Couto; Tânia Melo; Diana Lopes; Rita Pais; Joana Batista; et al. "Polar Lipids of Marine Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Mitigate the LPS-Induced Pro-Inflammatory Response in Macrophages". Marine Drugs (2023): https://doi.org/10.3390/md21120629. 10.3390/md21120629 Maria V. Monteiro; Margarida Henriques-Pereira; Bruno M. Neves; Iola D. Duarte; Vítor M. Gaspar; João F. Mano. "Photo-Compartmentalized Decellularized Matrix-Hyaluronan Hybrid Units for Pancreatic Tumor-Stroma Modeling". Advanced Functional Materials (2023): https://doi.org/10.1002/adfm.202305473. 10.1002/adfm.202305473 Isabel Ferreira; Gonçalo Brites; Ana Silva; Francisco Caramelo; Bárbara Oliveiros; Bruno Miguel Neves; Maria Teresa Cruz. "Development of an in chemico high-throughput screening method for the identification of skin sensitization potential". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-023-03550-z. 10.1007/s00204-023-03550-z Mateus, Daniela; Sebastião, AI; Frasco, Manuela F.; Carrascal, Mylène A.; Falcão, Amílcar; Gomes, Célia M.; Neves, Bruno; Sales, Maria G. F.; Cruz, Maria T.. Corresponding author: Cruz, Maria T.. "Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy". Small (2023): http://dx.doi.org/10.1002/smll.202303940. 10.1002/smll.202303940 Cátia Sousa; Bruno Miguel Neves; Alcino Jorge Leitão; Alexandrina Ferreira Mendes. "Molecular Mechanisms Underlying the Anti-Inflammatory Properties of (R)-(-)-Carvone: Potential Roles of JNK1, Nrf2 and NF-¿B". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15010249. 10.3390/pharmaceutics15010249 Cariny Polesca; Helena Passos; Bruno M. Neves; João A.P. Coutinho; Mara G. Freire. "Valorization of chicken feathers using aqueous solutions of ionic liquids". Green Chemistry (2023): http://dx.doi.org/10.1039/d2gc04477c. 10.1039/d2gc04477c Conde, Tiago; Aveiro, Susana; Melo, Tania; Santos, Tamara; Neves, Bruno; Domingues, Pedro; Varela, Joao; Pereira, Hugo; Domingues, M. Rosario. "Cross-stress lipid response of Tetraselmis striata CTP4 to temperature and salinity variation". Algal Research (2023): https://publons.com/wos-op/publon/63501697/. 10.1016/J.ALGAL.2023.103218 Gonçalo Brites; João Basso; Margarida Miranda; Bruno Miguel Neves; Carla Vitorino; Maria T. Cruz. "Development of a new hydrogel for the prevention of allergic contact dermatitis". International Journal of Pharmaceutics 628 (2022): 122265-122265. http://dx.doi.org/10.1016/j.ijpharm.2022.122265. 10.1016/j.ijpharm.2022.122265 Marcelo D. Catarino; Ana Rita Circuncisão; Bruno Neves; Catarina Marçal; Artur M. S. Silva; Maria Teresa Cruz; Susana M. Cardoso. "Impact of Gastrointestinal Digestion on the Anti-Inflammatory Properties of Phlorotannins from Himanthalia elongata". Antioxidants (2022): https://doi.org/10.3390/antiox11081518. 10.3390/antiox11081518 Sónia N. Pedro; Maria S. M. Mendes; Bruno M. Neves; Isabel Filipa Almeida; Paulo Costa; Inês Correia-Sá; Carla Vilela; et al. "Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partnership for the Transdermal Administration of Anti-Inflammatory Drugs". Pharmaceutics 14 4 (2022): 827-827. https://doi.org/10.3390/pharmaceutics14040827. 10.3390/pharmaceutics14040827 Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". 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Journal of Immunology 191 1 (2013): 262-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879675210&partnerID=MN8TOARS. 10.4049/jimmunol.1203518 Neves, B.M.; Rosa, S.C.; Martins, J.D.; Silva, A.; Goncìalo, M.; Lopes, M.C.; Cruz, M.T.. "Development of an in vitro dendritic cell-based test for skin sensitizer identification". Chemical Research in Toxicology 26 3 (2013): 368-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875168719&partnerID=MN8TOARS. 10.1021/tx300472d Francisco, V.; Costa, G.; Figueirinha, A.; Marques, C.; Pereira, P.; Miguel Neves, B.; Celeste Lopes, M.; et al. "Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-¿B pathway inhibition: Contribution of chlorogenic acid". Journal of Ethnopharmacology 148 1 (2013): 126-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878284536&partnerID=MN8TOARS. 10.1016/j.jep.2013.03.077 Santinha, D.R.; Marques, D.R.; Maciel, E.A.; Simões, C.S.O.; Rosa, S.; Neves, B.M.; Macedo, B.; et al. "Profiling changes triggered during maturation of dendritic cells: A lipidomic approach". Analytical and Bioanalytical Chemistry 403 2 (2012): 457-471. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861231971&partnerID=MN8TOARS. 10.1007/s00216-012-5843-8 Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.; Cruz, M.T.. "Signal transduction profile of chemical sensitisers in dendritic cells: An endpoint to be included in a cell-based in vitro alternative approach to hazard identification?". Toxicology and Applied Pharmacology 250 2 (2011): 87-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650559757&partnerID=MN8TOARS. 10.1016/j.taap.2010.10.003 da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E.. "Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression". Biochimica et Biophysica Acta - Molecular Cell Research 1813 10 (2011): 1863-1871. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051782996&partnerID=MN8TOARS. 10.1016/j.bbamcr.2011.06.018 Francisco, V.; Figueirinha, A.; Neves, B.M.; García-Rodríguez, C.; Lopes, M.C.; Cruz, M.T.; Batista, M.T.. "Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages". Journal of Ethnopharmacology 133 2 (2011): 818-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651410773&partnerID=MN8TOARS. 10.1016/j.jep.2010.11.018 Neves, Bruno; Rosa, Susana; Martins, Joao; Goncalo, Margarida; Lopes, Maria Celeste; Cruz, Maria Teresa. "An in vitro cell test for skin sensitizers prediction based on the analysis and integration of gene expression and signaling pathways activation". Journal of Investigative Dermatology 131 (2011): S91-S91. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000294361300538&KeyUID=WOS:000294361300538. Francisco, V.; Neves, B.M.; Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: Relevance of different signalling pathways". Archives of Dermatological Research 302 4 (2010): 271-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952180893&partnerID=MN8TOARS. 10.1007/s00403-009-0993-z Neves, B.M.; Silvestre, R.; Resende, M.; Ouaissi, A.; Cunha, J.; Tavares, J.; Loureiro, I.; et al. "Activation of phosphatidylinositol 3-kinase/akt and impairment of nuclear factor-¿B: Molecular mechanisms behind the arrested maturation/activation state of leishmania infantum-infected dendritic cells". American Journal of Pathology 177 6 (2010): 2898-2911. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650195216&partnerID=MN8TOARS. 10.2353/ajpath.2010.100367 Neves, B.M.; Cruz, M.T.; Francisco, V.; Garcia-Rodriguez, C.; Silvestre, R.; Cordeiro-da-Silva, A.; Dinis, A.M.; et al. "Differential roles of PI3-Kinase, MAPKs and NF-¿B on the manipulation of dendritic cell Th1/Th2 cytokine/chemokine polarizing profile". Molecular Immunology 46 13 (2009): 2481-2492. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650397827&partnerID=MN8TOARS. 10.1016/j.molimm.2009.05.021 Neves, B.M.; Cruz, M.T.; Francisco, V.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line". Toxicology Letters 177 1 (2008): 74-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-39549123001&partnerID=MN8TOARS. 10.1016/j.toxlet.2007.12.006 Cruz, M.T.; Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: Role of different immunosuppressive drugs". Immunopharmacology and Immunotoxicology 29 2 (2007): 225-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548553284&partnerID=MN8TOARS. 10.1080/08923970701512304
Journal issue	Neves, Bruno. "Dendritic Cell Vaccines". Pharmaceutics (2020): https://www.mdpi.com/journal/pharmaceutics/special_issues/dendritic_cell_vaccines#info. Published • Editor Neves, Bruno. "The Role of ER Stress and the UPR in Shaping Immunity". Frontiers in Immunology (2020): https://www.frontiersin.org/research-topics/9234/the-role-of-er-stress-and-the-upr-in-shaping-immunity. Published • Editor
Preprint	Clarissa Pérez Faria; Sandra Jesus; Ágata Lourenço; Bárbara Ferreira; Ana Isabel; Daniela Mateus; Bruno Neves; et al. "Unraveling the potential of Giardia extracellular vesicles as a vaccine candidat". 2024. https://doi.org/10.20944/preprints202403.0845.v1. 10.20944/preprints202403.0845.v1

Intellectual property

Patent

Neves, Bruno. 2024. "TOPICAL COMPOSITION AND USES THEREOF".
Neves, Bruno. 2023. "SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES".
Neves, Bruno. 2012. "METHOD FOR DETERMINING SKIN SENSITISATION POTENTIAL". Portugal.

Provisional application for patent

2022. "COMPOSITIONS, METHODS AND USES OF EXTRACELLULAR VESICLES OF GIARDIA SPP".
2016. "FUNCTIONALIZED MATRICES TO DETECT THE HAPTENIZATION CAPACITY OF XENOBIOTICS".
2016. "Method for Determining Low Molecular Weight Respiratory Allergens (Provisional Patent Application no)".
2015. "AN IN SILICO AND IN VITRO INTEGRATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
2015. "Method for determining low molecular weight respiratory allergens".
Disclosed

Other

Spin-off company

2011. Toxfinder Lda. In vitro predictive toxicology and pharmacological screening. http://toxfinder.pt/.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019/04/03	The unfolded protein response in the modulation of macrophage functions	7th Workshop in Immunology Universidade de Aveiro (Aveiro, Portugal)
2018/11/20	The unfolded protein response in the modulation of macrophage functions	Signaling Afternoon, DCM-UA Universidade de Aveiro (Aveiro, Portugal)
2016/09/16	Current status of dendritic cell-based tests for skin sensitizer identification	13th Congress of the European Society of Contact Dermatitis European Society of Contact Dermatitis (Manchester, United Kingdom)
2015/05/21	Dendritic cell vaccines in the fight against cancer: current status and future perspectives	III Workshop in Immunology University of Aveiro (Aveiro, Portugal)
2013/11/30	Exosomes as possible biomarkers to support the diagnosis / prognosis of tumors and autoimmune pathologies	XI Congresso de Análises Clínicas e Saúde Pública Sociedade Portuguesa de BioAnalistas Clínicos (Figueira da Foz, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09 - Current	Development and Characterization of 3D breast cancer models Co-supervisor	Biomedicina Molecular (Master) Universidade de Aveiro, Portugal
2023/09 - Current	Curricular internship at Evidenze Supervisor	Gestão da Investigação Clínica (Master) Universidade de Aveiro, Portugal
2023/09 - Current	Boosting anti-tumour immune response by creation of artificial immunogenic epitopes in cancer cells Supervisor	Biomedicina Molecular (Master) Universidade de Aveiro, Portugal
2022/10 - Current	Estágio BluePharma Supervisor	Gestão da Investigação Clínica (Master) Universidade de Aveiro, Portugal
2021/02/01 - Current	Contribution of water-soluble organic matter and its structural components to the oxidative and immunomodulatory effects of inhalable fine urban air particles Co-supervisor of Antoine Simões Almeida	Universidade de Aveiro Departamento de Química, Portugal
2021 - Current	Cell-based therapies for regenerative medicine and cancer Co-supervisor	Biomedicina Universidade de Aveiro, Portugal
2021 - Current	Priming immune system through exercise training to improve cancer outcomes Co-supervisor	Atividade Física e Saúde (PhD) Universidade do Porto, Portugal
2021 - Current	Development of biopolymeric nanomachines for theranostic applications Co-supervisor	Nanociências e Nanotecnologia (PhD) Universidade de Aveiro, Portugal
2021 - Current	Development of a prophylactic dendritic cell-based vaccine: the only way to halt triple-negative breast cancer? Co-supervisor	Ciências Farmacêuticas (PhD) Universidade de Coimbra, Portugal
2018/06 - 2024/01/05	Development of a Medical Device for prevention of Skin Sensitization Co-supervisor of Gonçalo Sousa Brites	Ciências Farmacêuticas (PhD) Universidade de Coimbra, Portugal
2020/11/10 - 2024/01	MiAL (MicroAlgae Lipids) – Exploitation of microalgae lipidome: a lipidomics strategy to bioprospect bioactive phytochemicals Co-supervisor	Universidade de Aveiro Departamento de Química, Portugal
2022/09 - 2023/12/12	Assessment of the pro-inflammatory potential of inhalable airborne particles in indoor environments Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2022/09 - 2023/12/07	Dendritic cell-based vaccines: Evaluating their anti-tumoral efficacy Supervisor	Biomedicina Molecular (Master) Universidade de Aveiro, Portugal
2022/09 - 2023/11/30	In vitro study of the impact of dysbiosis-related metabolites on the activation of human monocytes Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2022/09 - 2023/11/28	Bioprospection Of Avocado By-Products As A Source Of Lipids With Anti-Inflammatory Potential Anti-Inflammatory Potential Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2021 - 2022/12/13	Nanoparticles as a way to Boost Cancer Immunogenicity: A Novel Approach to Potentiate Antitumor Immunotherapy Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2021 - 2022/12/07	Monitorização de estudos na Keypoint, Group Evidente Co-supervisor	Gestão da Investigação Clínica (Master) Universidade de Aveiro, Portugal
2021 - 2022/11/29	Bioprospecting microalga Scenedesmus obliquus as a source of lipids with anti-inflammatory and antioxidant activity Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2021 - 2022/11/29	Bioprospecting Phaeodactylum tricornutum as a source of lipids with anti-inflammatory and anti-oxidant potential Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2020/09/01 - 2021/12/09	Flow cytometry immunological monitoring of patients with lung cancer undergoing immunotherapy Co-supervisor of Patrícia Pilar Gomes Oliveira Maia	Bioquímica Clínica (Master) Universidade de Aveiro Departamento de Química, Portugal
2020/09/01 - 2021/11/30	Bioprospecting red seaweed Palmaria palmata as source of bioactive lipids Co-supervisor	Bioquímica (Master) Universidade de Aveiro Departamento de Química, Portugal
2016 - 2021/04	Development of an in-vitro/in chemico platform to address chemical respiratory sensitization Co-supervisor	Ciências Farmacêuticas (PhD) Universidade de Coimbra, Portugal
2020/09/01 - 2021	Induced pluripotent stem cells (iPSC)-based cancer immunotherapy. Co-supervisor	Master in Molecular and Cell Biology (Master) Universidade de Aveiro Departamento de Biologia, Portugal
2017/03 - 2021	Potentiation of dendritic cells phenotypic and functional characteristics for application in next-generation cancer immunotherapy Supervisor of João Miguel Calmeiro Pereira	Ciências Farmacêuticas (PhD) Universidade de Coimbra, Portugal
2019 - 2019/12	Analysis of Monocyte-Derived Dendritic Cells Obtained Through Conventional vs. Fast Differentiation/Maturation Protocols Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2019 - 2019/12	Myeloid-derived suppressor cells (MDSC) analysis and their role in the Immunogram of cancer patients Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2018 - 2019	Skin sensitizers: new approaches for predicting toxicity and risk management Co-supervisor	Quimica Medicinal (Master) Universidade de Coimbra Departamento de Química, Portugal
2017 - 2017/12	Assessment of the inflamatory potential of inhalable organic aerosols present in an urban atmosphere Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2016 - 2017/01	Pterospartum tridentatum: Estudo fitoquímico e avaliação das atividades biológicas dos seus compostos Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2015 - 2015/12	Estudo do microbioma no sémen em casos e controlos de infertilidade Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2014 - 2015/04	Estudo das variações da sequência do gene CYP21A2 em doentes com hiperplasia adrenal congénita Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2013 - 2014/07	O Stress do Retículo na Remodelação do Perfil Lipídico do Macrófago Supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2013 - 2014	Contribution of ER stress to tumor immunosuppressive microenvironment Supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2013 - 2013/12	Regulation of the adrenergic system in mice adipose tissue under obesity Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2012 - 2013/06	Role of ER stress in sensitization induced DC maturation/toxicity Supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2012 - 2013/06	Deregulation of lipid homeostasis in Leishmania infantum -infected macrophages Supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal
2012 - 2012/12	Avaliação da PCT e da PCR no Diagnóstico de Sépsis no Recém-Nascido Co-supervisor	Bioquímica (Master) Universidade de Aveiro, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2022/07/22 - Current	2nd Workshop on Sphingolipids in Health and Disease (2022/07/22 - 2022/07/23) Workshop (Co-organisor)	Universidade de Aveiro, Portugal
2022/04/06 - Current	10th Workshop in Lipidomics - Lipidomics in health & disease (2022/04/06 - 2022/04/06) Workshop	Universidade de Aveiro, Portugal
2023/03/29 - 2023/03/31	XLVIII Annual Meeting of the Portuguese Society for Immunology (2023/03/29 - 2023/03/31) Meeting (Co-organisor)	Sociedade Portuguesa de Imunologia, Portugal
2016/05/25 - 2016/05/25	IV Workshop in Immunology (2016/05/25 - 2016/05/25) Workshop (Co-organisor)	Universidade de Aveiro, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022/12/15	Decifrando a interação entre as respostas anti virais dependentes da MAVS e da STING President of the jury	Rui Filipe Tavares Ferreira (Master) Universidade de Aveiro, Portugal
2022/11/25	Buffy Coat Vs blood collection tube mononuclear cells: a functional characterization President of the jury	Sofia de Morais Borges (Master) Universidade de Aveiro, Portugal
2022/11/21	A Novel Plant-Based Approach For The Treatment Of Pulmonary Arterial Hypertension (Thesis) Main arguer	Jorge Miguel Alves Silva. (PhD) Universidade de Coimbra, Portugal
2022/10/28	Construction of tumor lines resistant to antiglycolytic agents to evaluate the effect on cell metabolism and viability President of the jury	Ana Catarina Gonçalves da Rocha (Master) Universidade de Aveiro, Portugal
2022/10/12	Development of a Defined Approach for Respiratory Sensitization Hazard Assessment (Thesis) Main arguer	Rita Isabel Azambuja Lavrador (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/07/20	Contrast agents to map living tissue access to oxygen (Thesis) Main arguer	Maria Carolina Roseiro Ferrão Lopes (Other) Universidade de Aveiro, Portugal
2022/02/09	Decoding the Crosstalk Between Dendritic Cells and Bladder Cancer – Associated Glycans: A Way to Identify Novel Immunotherapy Targets (Thesis) Main arguer	Andreia Rafaela Linhares Miranda (Master) Universidade do Porto, Portugal
2021/12/06	Potentiation. of Dendritic Cell Phenotypic and Functional Characteristics for Application in Next-generation Cancer Immunotherapy Supervisor	João Miguel Calmeiro Pereira (PhD) Universidade de Coimbra, Portugal
2021/12/04	Toxicological impact of three pharmacological therapeutics on human sperm President of the jury	Carolina Capucha Garcia (Master) Universidade de Aveiro, Portugal
2021/11/23	UNRAVELING THE AXONAL PROTEOME OF HIPPOCAMPAL NEURONS President of the jury	José João Macedo Felgueiras (Master) Universidade de Aveiro, Portugal
2021/11/17	Molecular mechanisms of macrophages adaptation when supplemented with phospholipids with Omega-3 and Omega-6 fatty acids (Thesis) Main arguer	Tatiana Sofia Cardoso Maurício (Master) Universidade de Aveiro, Portugal
2021/07/27	Genotype-phenotype characterization of patients with Autism Spectrum Disorder – Analysis of copy number variation President of the jury	Tatiana da Cruz Almeida (Master) Universidade de Aveiro, Portugal
2021/02/25	Analysis of Fig4 interfered cells and its role on the endocytic pathway (Thesis) Main arguer	Tiago Pinto Vieira (Master) Universidade de Aveiro, Portugal
2021/01/21	Plasma phospholipidome analysis reveals a different profile between children with phenylketonuria and healthy children (Thesis) Main arguer	Inês Maria dos Santos Guerra (Master) Universidade de Aveiro Departamento de Química, Portugal
2021/01/05	Dissecting the mechanisms governing skin wound healing induced by an UCB-derived product (Thesis) Arguer	Sílvia Maria do Couto Rodrigues (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/12/10	Dendritic cell-based cancer immunotherapy the role of DC-NK crosstalk (Thesis) Main arguer	Daniel Alexandre Bento Ferreira (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/09	Characterization of a-GlcCer reactive iNKT cells and MAIT cells of Gaucher disease patients (Thesis) Main arguer	RAFAEL CARNEIRO LOPES (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/03	Study of VTN, PLG and other coagulation genes in atypical Hemolytic Uremic Syndrome (aHUS)	Jéssica Filipa Pires Malva (Master) Universidade de Aveiro Departamento de Química, Portugal
2020/10/26	Development of Biomimetic Pancreatic Cancer 3D in vitro Models for Preclinical Drug Screening (Thesis) Main arguer	MARIA VINHAS MONTEIRO (Master) Universidade de Aveiro, Portugal
2019/12/11	Testing the combinatory use of PARPI and RPA inhibitors in breast cancer cell lines President of the jury	Tatiana Natália Tavares Magro (Master) Universidade de Aveiro, Portugal
2019/09	The Macrophage-iNKT axis: macrophage survival and activation are modulated upon invariant NKT interaction (Thesis) Main arguer	José Pedro Pereira Loureiro (Master) Universidade de Coimbra, Portugal
2018/12/10	The interplay between human cytomegalovirus and peroxisomes: metabolism and membrane association with the endoplasmic reticulum President of the jury	Beatriz Soares Carneiro da Silva (Master) Universidade de Aveiro, Portugal
2018	Flavonoid-mediated modulation of human macrophages phospholipidome: an LC-MS lipidomics study (Thesis) Main arguer	Tiago Alexandre Teixeira de Sousa Conde (Master) Universidade de Aveiro, Portugal
2016/12	Assessment of potential anti-tumour agents for photodynamic therapy (Thesis) Main arguer	Inês Mendes Sardo (Master) Universidade de Aveiro, Portugal
2016/09	The interaction of Giardia Lamblia with macrophages cells: the action of parasite protéases on iNOS, COX-2 and p65RelA inflammatory proteins (Thesis) Main arguer	Ágata Filipa Bandeira Lourenço (Master) Universidade de Coimbra, Portugal
2015/09	Impact of chemotherapeutic drugs in NK-mediated killing by over expression of death receptors on cancer cells (Thesis) Main arguer	Ana Filipa Fernandes Gomes (Master) Universidade de Coimbra, Portugal
2014/07	Studies of the interaction between heme oxygenase-1 and human HBP (Thesis) Main arguer	Iga Karolina Jodlowska (Master) Universidade de Aveiro, Portugal
2014/07	Analysis of human genomes of Portuguese individuals President of the jury	Ana Carolina Marianito Serrano (Master) Universidade de Aveiro, Portugal
2014/06	CD5, A Molecular Switch Regulating Signaling at the Surface of T Cells (Thesis) Main arguer	Ana Rita Santos (Master) Universidade de Aveiro, Portugal
2014/06	Novos biomateriais baseados em celulose bacteriana para aplicações biomédicas President of the jury	Bruno Filipe Afonso Valente (Master) Universidade de Aveiro, Portugal
2013/07	Drug discovery of new anti-inflammatory phytochemicals using in vitro guided assays: The case study of Cymbopogon citratus (Thesis) Arguer	Vera Lúcia Gomes Francisco (PhD) Universidade de Coimbra, Portugal
2013/07	Lipidomic and proteomic in cancer-related skeletal muscle wasting (Thesis) Main arguer	Diana Sofia Ribeiro Duarte Antunes (Master) Universidade de Aveiro, Portugal
2013/07	Estudo da Função Renal em Pacientes Com Diabetes Mellitus President of the jury	Andrea Janeth da Silva da Silva (Master) Universidade de Aveiro, Portugal
2013/07	Complicações das estratégias de Reinfusão em Cirurgias Ortopédicas	Daniela Sofia Bandeira Gomes Duarte (Master) Universidade de Aveiro, Portugal
2012/12	Análise da histona H2A tipo 2-C na diferenciação celular e no cancro da mama (Thesis) Main arguer	Celestina Gomes Lopes (Master) Universidade de Aveiro, Portugal
2012/07	Perfil lipídico de Cérebro e Coração de Ratinhos com Stress Crónico President of the jury	Renata Alexandra Boaventura Faria (Master) Universidade de Aveiro, Portugal

Committee member

	Activity description Role	Institution / Organization
2022/07/01 - Current	Member of the Pedagogical Quality and Evaluation Council of the Department of Medical Sciences of the University of Aveiro. Member	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022/06/01 - Current	Member of the Board of the Department of Medical Sciences of the University of Aveiro. Member	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/10/01 - Current	Director of the Biomedical Sciences degree at Department of Medical Sciences, University of Aveiro Director	Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/06/01 - Current	Member of the Scientific Council of the Institute of Biomedicine (iBiMED) of the University of Aveiro Member	Universidade de Aveiro Instituto de Biomedicina, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2020/12 - Current	Evaluation of National projects for the National Innovation Agency (ANI) Evaluator	Universidade de Aveiro, Portugal	Agência Nacional de Inovação SA
2021 - 2021	Reviewer of projects submited to the Dutch Cancer Society (KWF) Evaluator	KWF Kankerbestrijding, Netherlands	KWF Kankerbestrijding
2017 - 2017	Member of the evaluation panel of scientific projects in the areas of Cellular and Molecular Biology and Immunology Evaluator	National Center of Science and Technology Evaluation Ministry of Education and Science Republic of Kazakhstan, Kazakhstan

Journal scientific committee

	Journal title (ISSN)	Publisher
2021 - Current	Translational Oncology (1936-5233)	Elsevier
2020 - Current	Molecules (1420-3049)	MDPI
2020 - Current	Molecular Therapy: Methods & Clinical Development (23290501)	Elsevier
2020 - Current	Journal of Clinical Medicine (2077-0383)	MDPI
2020 - Current	Journal of European Academy of Dermatology Venereology (1468-3083)	Wiley
2016 - Current	European Journal of Pharmaceutical Sciences (0928-0987)	Elsevier
2016 - Current	Scientific Reports (2045-2322)	Springer Science and Business Media LLC
2014 - Current	Drug Design Development and Therapy (1177-8881)	Dove Medical Press
2012 - Current	International Journal of Nanomedicine (1178-2013)	Dove Medical Press

Mentoring / Tutoring

	Topic	Student name
2014/05/12 - 2015/07/31	Development of an in vitro cell test for skin sensitizer identification	Ana Cristina R. Silva

Distinctions

Award

2021	Award for the best poster presentation - VI Jornadas da Bioquímica
2018	Best Poster Award European Society of Contact Dermatitis, Germany
2018	ImmunoTools Special Award ImmunoTools , Germany
2014	Entrepreneurship award: Bolsa de Ignição INOV.Capital Universidade de Coimbra, Portugal
2013	Award for innovation and entrepreneurship (First prize) Biocant and Caixa de Crédito Agrícola, Portugal
2012	Regional Business Ideas Competition RIERC 2012 (First Prize) Rede de Incubadoras de Empresas da Região Centro, Portugal
2011	Idea to Product Portugal Competition (3rd prize) COTEC Portugal, Portugal
2010	Entrepreneurship award: Bolsa de Ignição INOV.C 2010 (First Prize) Universidade de Coimbra, Portugal
2009	Prix de Recherche Sientifique Lierac Alès Groupe, France
2008	Best Poster Award European Society of Contact Dermatitis, Germany