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Ana Magalhães graduated in Biochemistry (2005) and holds a PhD in Biomedicine (2011) by University of Porto. She got trained in proteomics at the BRC-Centre of Excellence of the European Union (Hungary), in Proximity Ligation Assays at Uppsala University (Sweden), in cancer glycobiology at the Institute of Molecular Pathology and Immunology of University of Porto (Portugal) and in bacterial adhesion and pathogen adaptation at Umea University (Sweden). Ana co-authored more than 50 scientific articles, including highly prestigious journals such as Cancer Cell, PNAS, Nature Cell Biology, Developmental Cell and J Biol Chem. Her publications have received more than 3100 citations (H-index 31). She has successfully complete the supervision of 5 PhD and 7 MSc students, as main or co-supervisor. All these dissertations articulate fundamental and clinical research. At present, Ana is an Assistant Professor of Biochemistry at ICBAS- Scholl of Medicine and Biomedical Science and Investigator at i3S - University of Porto and her main research interests are focused on the mechanistic roles of proteoglycans in cancer-extracellular matrix dynamics and cell communication and signaling.
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Identification

Personal identification

Full name
Ana Maria Rodrigues Leite de Magalhães
Date of birth
1983/07/03
Gender
Female

Citation names

  • Magalhães, Ana

Author identifiers

Ciência ID
7F12-C63C-9728
ORCID iD
0000-0003-4863-6668
Scopus Author Id
55069336800

Email addresses

  • amagalhaes@ipatimup.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6067 (Professional)

Addresses

  • Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2011/10/18
Concluded
 Biomedicine (Doutoramento)
Medical faculty, University of Porto, Portugal
"Characterization of molecular mechanisms relevant for Helicobacter pylori adhesion mediated by glycoconjugates expressed in gastric mucosa"" (THESIS/DISSERTATION)
 Approved by unanimity with distinction
2001/09/01 - 2005/12/14
Concluded
 Biochemistry (Licenciatura)
Faculty of Sciences, University of Porto, Portugal
 17/20 (awarded best classification of the year)
2005/01 - 2005/08
Concluded
 Research training (ERASMUS program) (Outros)
Biological Research Centre, Szeged Centre of Excellence of the European Union, Hungary
Affiliation

Science

Category
Host institution 		Employer
2017/08/01 - Current Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01/01 - 2017/07/31 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2012/09/01 - 2012/09/30 Visiting Researcher (Research) Umea Universitet, Sweden
2010/06/07 - 2010/06/19 Visiting Researcher (Research) Uppsala Universitet Rudbecklaboratoriet, Sweden
Uppsala Universitet Rudbecklaboratoriet, Sweden
2010/04 - 2010/06 Visiting Researcher (Research) Umea Universitet, Sweden
Umea Universitet, Sweden
2005/01 - 2005/08 Visiting Researcher (Research) Biological Research Centre, Szeged Centre of Excellence of the European Union, Hungary
Biological Research Centre, Szeged Centre of Excellence of the European Union, Hungary

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/06 - Current Assistant Professor (University Teacher) Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005/05/01 - 2021/08/31 Lecturer (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Grant

Designation Funders
2022/01/01 - Current GLYCOTARGET. A NEW FRONTIER IN EXTRACELLULAR VESICLE-MEDIATED CANCER IMMUNOMODULATION
PTDC/MEC-ONC/0491/2021
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/12 - Current COST ACTION 18103 - Innovation with Glycans: new frontiers from synthesis to new biological targets
CA18103
Researcher
European Union
Ongoing
2023 - 2025 gBiOT – Nutraceutical biopolymeric-biocatalytic microbot against gut inflammatory disorders
2022.02926.PTDC
Ongoing
2023 - 2024 Erbb2 Molecular hEterogeneity dRives Glycan-mEdiated trastuzumab resistaNCE
2022.04138.PTDC
Researcher
Ongoing
2018/11/22 - 2021/11/21 Mechano-dependent capture of Circulating Tumour Cells: a cell-ECM based approach coupled with cancer specific glycomarkers
PTDC/BTM-SAL/30383/2017
Researcher
University of Porto - IPATIMUP, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
Ongoing
2018/07 - 2021/06/30 GLYcanMATRIX - Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression
POCI-01-0145-FEDER-028489
PTDC/MED-ONC/28489/2017
Principal investigator
University of Porto - IPATIMUP, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2019/12/31 Advanced cancer research: from basic knowledge to application
NORTE-01-0145-FEDER-000029
Researcher
University of Porto - IPATIMUP, Portugal
 European Regional Development Fund
Concluded
2016/06 - 2019/06 PYLORIBINDERS - Helicobacter pylori specific biomaterials for antibiotic-free treatment/diagnostic of gastric infection
PTDC/CTM-BIO/4043/2014
Researcher
University of Porto - IPATIMUP, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
Ongoing
2013/06 - 2017/05 Systems Glycobiology of Gastric Cancer - Marie Curie ITN
316929
Researcher
University of Porto - IPATIMUP, Portugal
 European Union
Concluded
2014/03 - 2015/08 SWEETMIC: Helicobacter pylori entrapment using “sweet” microsponges: a new alternative for gastric infection treatment
EXPL/CTM-BIO/0762/2013
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciencia e a Tecnologia (FCT)
Concluded
2013/06/01 - 2015 Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells.
info:eu-repo/grantAgreement/FCT/COMPETE/125428/PT
Researcher
Fundação para a Ciência e a Tecnologia
2011/04/01 - 2014 E-cadherin Post-Translational Modifications by N-glycosylation: a potential new mechanism of E-cadherin deregulation in cancer
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/111358/PT
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012 Early detection of cancer using serum biomarkers based on aberrant post-translational modifications of O-glycoproteins, O-PTM-Biomarkers.
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/82716/PT
Researcher
Fundação para a Ciência e a Tecnologia
2007 - 2011 A strategy for preventing H. pylori-associated gastric cancer based on materials with specific receptors to the bacteria - from SAMs to Gly-R chitosan microspheres
PTDC/CTM/65330/2006
Researcher
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2012 - 2017/07 Gastric cancer glycosignature
SFRH/BPD/75871/2011
Post-doc Fellow
Fundação para a Ciencia e a Tecnologia (FCT)
2007 - 2011 Helicobacter pylori adhesion mediated by glycoconjugates expressed in gastric mucosa
SFRH/BD/36339/2007
PhD Student Fellow
Fundação para a Ciencia e a Tecnologia (FCT)
2005 - 2007 Identification of glycan-related genes induced by Helicobacter pylori in gastric cells: Glycomics
POCI/SAU-OBS/56686/2004
Research Fellow
Fundação para a Ciencia e a Tecnologia (FCT)
Concluded
Outputs

Publications

Book chapter
  1. Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Glycans and Cancer". In Encyclopedia of Cell Biology, 373-384. Elsevier, 2023.
    10.1016/b978-0-12-821618-7.00019-5
  2. Reis, Celso A.; Magalhães, Ana. "Glycosyltransferases and Gastric Cancer". In Glycosignals in Cancer: Mechanisms of Malignant Phenotypes, 17-32. Springer Japan, 2016.
    Published • 10.1007/978-4-431-55939-9_2
Conference poster
  1. Catarina Marques; Magalhães, Ana. "Disclosing the regulatory roles of EXTL2 and EXTL3 on cancer cell GAGosylation and impact on tumorigenic features". Paper presented in 7th Molecular and Cell Biology Symposium | Science Must Go On | 29th January 2021 - Virtual event via Zoom, 2021.
  2. Juliana Poças; Magalhães, Ana. "Glycoconjugates as key players in cancer cell communication". Paper presented in Virtual ISEV workshop EV imaging in vivo September 10-11th, 2020- Virtual event via Zoom, 2020.
  3. Juliana Poças; Magalhães, Ana. "Cell surface glycoconjugates as key players in gastric cancer". Paper presented in EMBO Pratical Course "Extracellular Vesicles: from biology to biomedical applications", 2019.
  4. Magalhães, Ana. "Cancer cell derived extracellular vesicles carry tumour associated glycan epitopes". Paper presented in 25th International Symposium on Glycoconjugates, Milan, Italy, 2019.
  5. Catarina Marques; Magalhães, Ana. "Novel insights on Heparan Sulfate ProteoGlycans biosynthetic pathways and its functional relevance in cancer". Paper presented in i3S Annual Meeting, 2019.
  6. Catarina Marques; Isabel Faria-Ramos; Magalhães, Ana. "Uncovering Heparan Sulfate ProteoGlycans biosynthesis pathways and functional relevance in gastric cancer". Paper presented in 13th International Meeting of the Portuguese Carbohydrate group, 2019.
  7. Juliana Poças; Magalhães, Ana. "Cell surface Heparan sulfate Proteoglycans as leading maestros of cancer cell behaviour". Paper presented in 13th International Meeting of the Portuguese Carbohydrate group, 2019.
  8. Juliana Poças; Magalhães, Ana. "Syndecan-4 is overexpressed in gastric cancer and associates with tumour aggressive features". Paper presented in 7 Lakes Proteoglycans Conference, Varese, Italy, 2017.
  9. Juliana Poças; Magalhães, Ana. "Syndecan-4 expression in gastric cancer and its implications in cancer cell aggressiveness features". Paper presented in British Society of Matrix Biology Meeting, Oxford UK, 2017.
  10. Mereiter, Stefan; Magalhães, Ana. "Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer". Paper presented in SFG Annual Meeting, New Orleans, USA, 2016.
  11. Magalhães, Ana. "The glycan receptors of Helicobacter pylori: decoding the pathways underlying gastric glycophenotype modulation". Paper presented in SFG Annual Meeting - New Orleans, USA, 2016.
  12. Mereiter, Stefan; Magalhães, Ana. "Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer". Paper presented in 2nd ASPIC International Congress, Porto, Portugal, 2016.
  13. Daniela Freitas; Magalhães, Ana. "Premature truncation of O-glycans in gastric cancer promotes aggressive phenotype". Paper presented in i3S Annual Meeting 2016 - Povoa do Varzim, Portugal, 2016.
  14. Mereiter, Stefan; Magalhães, Ana. "Glycomic analysis discloses glycans as modulators of RON receptor tyrosine kinase activation in gastric cancer". Paper presented in i3S Annual Meeting- Povoa do varzim, Portugal, 2016.
  15. Magalhães, Ana. "The sweet receptors of Helicobacter pylori: decoding the pathways underlying gastric glycophenotype modulation". Paper presented in i3S Annual Meeting - Povoa do Varzim, Portugal, 2016.
  16. Freitas, D.; Magalhaes, A.; et al.. "Biological impact of simple O-glycans in gastric cancer using glycoengineered cells". Paper presented in Extracellular Vesicles Purification, Identification and Translation - EMBL, Heidelberg, Germany, 2015.
  17. Mereiter, S.; et al.. "Glycome and syaloproteome characterization of gastric cancer cells overexpressing sialylated terminal glycans". Paper presented in GLYCO23 23rd International Symposium on Glycoconjugates, Split, Croatia, 2015.
  18. Magalhães, Ana. "Biological impact of simple O-glycans in gastric cancer using glycoengineered cells". Paper presented in 11th International Meeting of the Portuguese Carbohydrate group-GLUPOR11-and 6th Iberian Carbohydrate Meeting, 2015.
  19. Daniela Freitas; Magalhães, Ana. "Biological impact of simple O-glycans in gastric cancer using glycoengineered cells". Paper presented in 5th Advanced Summer School: Interrogations at the Biointerface- the Nano/Medicine Interface, 2015.
  20. Daniela Freitas; Magalhães, Ana. "Biological impact of simple O-glycans in gastric cancer using glycoengineered cells". Paper presented in CNIO Frontiers Meeting 2015 "Metastasis Initiation - Mechanistic insights and therapeutic opportunities, 2015.
  21. Magalhães, Ana. "Helicobacter pylori chronic infection and mucosal inflammation switches the gastric glycophenotype". Paper presented in Advanced Summer School - the nano/medicine interface, Porto, 2015.
  22. Campos, D.; et al.. "The Identification of sialyl-Tn /Tn O-Glycoproteins in cancer cells and patients serum". Paper presented in International Symposium on Glycosyltransferases. Porto, Portugal, 2014.
  23. Magalhães, Ana; et al.. "Helicobacter pylori chronic infection remodels the gastric mucosa glycophenotype". Paper presented in 12th International Workshop on Carcinoma-associated Mucins, Cambridge, UK, 2013.
  24. Magalhães, A; Reis, C.A.. "Alterations of glycosylation induced by Helicobacter pylori during gastric carcinogenesis". Paper presented in 17th International Workshop on Campylobacter, Helicobacter and Related Organisms, Aberdeen, UK, 2013.
  25. Gonçalves, I.C.; et al.. "Helicobacter pylori-binding biomaterials as alternative treatment for gastric infection". Paper presented in XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer. Madrid, Spain, 2013.
  26. Magalhães, Ana; et al.. "Characterisation of the glycosyltransferases underlying human gastric mucosa glycophenotype modulation by Helicobacter pylori". Paper presented in GLYCO-T 2012 – 8th International Symposium on Glycosyltransferases, Hannover, Germany, 2012.
  27. Gomes, J.; Magalhães, Ana; et al.. "Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter infection". Paper presented in GLYCO-T 2012 – 8th International Symposium on Glycosyltransferases, Hannover, Germany, 2012.
  28. Gomes, J.; Magalhães, Ana; et al.. "Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection". Paper presented in 3rd I3S Scientific Retreat, 2012.
  29. Magalhães, Ana; et al.. "Muc5ac mucin carries histo-blood group type 1 antigens in mice gastric mucosa". Paper presented in 3rd I3S Scientific Retreat, 2012.
  30. Gonaçalves, I.C.; et al.. "Engineered biomaterials to prevent/treat gastric infection.". Paper presented in International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration. Hangzhou, China, 2012.
  31. Magalhães, Ana; et al.. "Modulation of the expression of Helicobacter pylori glycan receptors in gastric mucosa.". Paper presented in 2nd I3S Scientific Retreat, Povoa do Varzim, Portugal, 2011.
  32. Pinto, R.; et al.. "Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation.". Paper presented in 2nd I3S Scientific Retreat May, Povoa do Varzim, Portugal, 2011.
  33. Parreira, P.; Magalhães, A; et al.. "Engineering surfaces to promote Helicobacter pylori binding: an approach to an alternative treatment.". Paper presented in 2nd I3S Scientific Retreat May, Povoa do Varzim, Portugal,, 2011.
  34. Parreira, P.; Magalhaes, A.; et al.. "Immobilization of specific receptors for Helicobacter pylori using model surfaces.". Paper presented in I3S Retreat, Póvoa do Varzim, Portugal, 2010.
  35. Parreira, P.; Magalhaes, A.; et al.. "Immobilization of specific receptors for Helicobacter pylori using model surfaces.". Paper presented in 23rd European Conference on Biomaterials. September 11-15, Tampere, Finland, 2010.
  36. Magalhães, Ana; et al.. "Evaluation of Helicobacter pylori adhesion to gastric mucosa of FUT2-null mice". Paper presented in 10th International Workshop on Carcinoma-associated Mucins, Cambridge, UK, 2009.
  37. Magalhaes, A.; et al.. "FUT2-null mice show impaired BabA-mediated adhesion of Helicobacter pylori to gastric mucosa.". Paper presented in XXII International Workshop on Helicobacter and related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Porto, 2009.
  38. Camilo, V.; et al.. "BMP and H-pylori Downregulate SOX2 Expression in Gastric Cell Lines". Paper presented in XXII International Workshop on Helicobacter and related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Porto, 2009.
  39. Gomes, J.; et al.. "Biologic Role of Pteridium aquilinum in Gastric Epithelial Cells: Potential Synergistic Effect with H. pylori Infection". Paper presented in XXII International Workshop on Helicobacter and related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Porto, 2009.
  40. Parreira, P.; et al.. "Immobilization of a Specific Receptor for H. pylori Using Model Surfaces". Paper presented in XXII International Workshop on Helicobacter and related Bacteria in Chronic Digestive Inflammation and Gastric Cancer, Porto, 2009.
  41. Parreira, P.; et al.. "Helicobacter pylori Adhesion to Gold and to Model Surfaces with Different Surface Chemistry.". Paper presented in 22nd European Conference on Biomaterials. Lausanne, Switzerland, 2009.
  42. Parreira, P.; et al.. "Immobilization of a Helicobacter pylori binding receptor onto nanostructured surfaces.". Paper presented in 10th Advanced Summer Course in Cell-Material Interactions. Porto, 2009.
  43. Magalhaes, A.; et al.. "Helicobacter pylori cag pathogenicity island induces the expression of syndecan-4 in gastric epithelial cells". Paper presented in 8th International Workshop on Pathogenesis and Host Response in Helicobacter Infections, Helsingor, Denmark, 2008.
  44. Parreira, P.; et al.. "Helicobacter pylori adhesion to Gold, hydrophilic and hydrophobic self-assembled monolayers (SAMs)". Paper presented in XXIst International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer .Riga, Latvia, 2008.
  45. Parreira, P.; et al.. "Kinetics of Helicobacter pylori adhesion to Gold and EG4-SAMs.". Paper presented in 9th Advanced Summer Course in Cell-Material Interactions, Porto, 2008.
  46. Marcos, N.T.; et al.. "Role of Sialyl-Tn carbohydrate antigen in the development of malignant phenotype of gastric carcinoma cells". Paper presented in American Association for Cancer Research, Annual Meeting 2007, Los Angeles, CA, 2007.
  47. Magalhães, A.; et al.. "Genetically altered mice with different glycosyltransferase deficiencies show different expression of Lewis antigens in the gastric mucosa.". Paper presented in 9th International Workshop on Carcinoma-associated Mucins, Cambridge, UK, 2007.
  48. Marcos, N.T.; Magalhaes, A.; et al.. "B3GlcNAc-T5 induction in gastric epithelial cells by Helicobacter pylori leads to expression of sialyl-Lewis X, the ligand for SabA adhesion.". Paper presented in 9th International Workshop on Carcinoma-associated Mucins, Cambridge, UK, 2007.
  49. Reis, C.A.; et al.. "Differencial expression of glycosylation related genes induced by Helicobacter pylori strains in human gastric cells". Paper presented in Benzon Symposium - Glycosylation: opportunities in Drug Development, Copenhagen, 2007.
  50. Magalhães, A.; et al.. "Genetically altered mice with different glycosyltransferase deficiencies show different expression of Lewis antigens in the gastric mucosa". Paper presented in 7th International Meeting of the Portuguese Carbohydrate Group - Glupor 7, ITQB-Oeiras, 2007.
  51. Magalhães, A.; et al.. "Genetically altered mice with different glycosyltransferase deficiencies show different expression of Lewis antigens in the gastric mucosa.". Paper presented in Annual Conference of the Society for Glycobiology, Boston, MA, 2007.
  52. Marcos, N.T.; Magalhaes, A.; et al.. "Beta3GlcNac-T5 induction in gastric epithelial cells by Helicobacter pylori leads to expression of sialyl-Lewis x, the ligand for SabA adhesin.". Paper presented in Annual Conference of the Society for Glycobiology, Boston, MA, 2007.
  53. Magalhaes, A.; et al.. "Alteration of expression of Syndecan-4 in gastric cell line induced by Helicobacter pylori". Paper presented in 2006 Meeting of the Society for Glycobiology, California, 2006.
  54. Marcos, N.T.; et al.. "Gene expression alterations mediated by Helicobacter pylori strains of different pathogenicity – a focus on glycosylation". Paper presented in 2006 Meeting of the Society for Glycobiology, California, 2006.
  55. Carvalho, A.S.; et al.. "Biosynthesis of sialylated Lewis antigens in human gastric carcinoma cells: combined role of alpha2,3sialyltransferases and alpha3/4fucosyltransferases". Paper presented in 2006 Meeting of the Society for Glycobiology, California, 2006.
  56. Magalhães, A.; et al.. "Alteration of expression of Syndecan-4 in gastric cell line induced by Helicobacter pylori". Paper presented in XV Congresso Nacional de Bioquímica, Aveiro, 2006.
  57. Klem, J.; Magalhães, A.; et al.. "Reduction and Alkylation of Proteins for Two-dimensional Gel Electrophoresis". Paper presented in 4th Annual World Congress of the Human Proteome Organisation (HUPO), Munich, Germany, 2005.
Journal article
  1. Poças, Juliana; Marques, Catarina; Gomes, Catarina; Otake, Andreia Hanada; Pinto, Filipe; Ferreira, Mariana; Silva, Tiago; et al. "Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival". Proceedings of the National Academy of Sciences 120 20 (2023): http://dx.doi.org/10.1073/pnas.2214853120.
    10.1073/pnas.2214853120
  2. Catarina Marques; Juliana Poças; Catarina Gomes; Isabel Faria-Ramos; Celso A. Reis; Romain R. Vivès; Ana Magalhães. "Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion". Journal of Biological Chemistry (2022): https://doi.org/10.1016/j.jbc.2022.102546.
    10.1016/j.jbc.2022.102546
  3. Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell 57 4 (2022): 440-450.e7. http://dx.doi.org/10.1016/j.devcel.2021.12.008.
    10.1016/j.devcel.2021.12.008
  4. Matos, Rita; Sousa, Hugo Santos; Nogueiro, Jorge; Magalhães, Ana; Reis, Celso A.; Carneiro, Fátima; Amorim, Irina; Haesebrouck, Freddy; Gärtner, Fátima. "Helicobacter species binding to the human gastric mucosa". Helicobacter 27 1 (2021): http://dx.doi.org/10.1111/hel.12867.
    10.1111/hel.12867
  5. Marques, Catarina; Reis, Celso A.; Vivès, Romain R.; Magalhães, Ana. "Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.778752.
    10.3389/fonc.2021.778752
  6. Matos, Rita; Amorim, Irina; Magalhães, Ana; Haesebrouck, Freddy; Gärtner, Fátima; Reis, Celso A.. "Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role". Frontiers in Molecular Biosciences 8 (2021): http://dx.doi.org/10.3389/fmolb.2021.656439.
    10.3389/fmolb.2021.656439
  7. Silva, Lisete M.; Correia, Viviana G.; (...); Magalhães, Ana; Reis, Celso A.; Feizi, Ten; Ferreira, José A.; Coimbra, Manuel A.; Palma, Angelina S.. "Helicobacter pylori lipopolysaccharide structural domains and their recognition by immune proteins revealed with carbohydrate microarrays". Carbohydrate Polymers 253 (2021): 117350. http://dx.doi.org/10.1016/j.carbpol.2020.117350.
    Open access • Published • 10.1016/j.carbpol.2020.117350
  8. Faria-Ramos, Isabel; Poças, Juliana; Marques, Catarina; Santos-Antunes, João; Macedo, Guilherme; Reis, Celso A.; Magalhães, Ana. "Heparan Sulfate Glycosaminoglycans: (Un)Expected Allies in Cancer Clinical Management". Biomolecules 11 2 (2021): 136. http://dx.doi.org/10.3390/biom11020136.
    Open access • Published • 10.3390/biom11020136
  9. Matos, Rita; Fonseca, Kaori L.; (...); Rodrigues, Pedro N. S.; Reis, Celso A.; Saraiva, Margarida; Magalhães, Ana. "Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium". Microorganisms 9 1 (2021): 99. http://dx.doi.org/10.3390/microorganisms9010099.
    Open access • Published • 10.3390/microorganisms9010099
  10. Magalhães, Ana; Duarte, H.O.; Reis, CA. "The role of O-glycosylation in human disease (Invited Review)". Molecular Aspects of Medicine (2021):
    Accepted
  11. Maia, Joana; Otake, Andreia Hanada; Poças, Juliana; Carvalho, Ana Sofia; Beck, Hans Christian; Magalhães, Ana; Matthiesen, Rune; Strano Moraes, Maria Carolina; Costa-Silva, Bruno. "Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.592518.
    Open access • Published • 10.3389/fcell.2020.592518
  12. Henriques, Patrícia C.; Costa, Lia M.; (...); Magalhães, Ana; (...; Martins, M.C.L.; Gonçalves, Inês C.. "Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice". Acta Biomaterialia 114 (2020): 206-220. http://dx.doi.org/10.1016/j.actbio.2020.06.035.
    10.1016/j.actbio.2020.06.035
  13. Kaori Fonseca; Ana Maceiras; Rita Matos; (...); Magalhães, Ana; Margarida Saraiva. "Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils". Mucosal Immunology (2020):
    Open access • Accepted
  14. Freitas, Daniela; Balmaña, Meritxell; Poças, Juliana; Campos, Diana; Osório, Hugo; Konstantinidi, Andriana; Vakhrushev, Sergey Y.; Magalhães, Ana; Reis, Celso A.. "Different isolation approaches lead to diverse glycosylated extracellular vesicle populations". Journal of Extracellular Vesicles 8 1 (2019): 1621131. http://dx.doi.org/10.1080/20013078.2019.1621131.
    10.1080/20013078.2019.1621131
  15. Mereiter, Stefan; Martins, Álvaro M.; Gomes, Catarina; Balmaña, Meritxell; Macedo, Joana A.; Polom, Karol; Roviello, Franco; Magalhães, Ana; Reis, Celso A.. "O-glycan truncation enhances cancer-related functions of CD44 in gastric cancer". FEBS Letters 593 13 (2019): 1675-1689. http://dx.doi.org/10.1002/1873-3468.13432.
    10.1002/1873-3468.13432
  16. Freitas, Daniela; Campos, Diana; Gomes, Joana; Pinto, Filipe; (...); Magalhães, A; Reis, Celso A.. "O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype". EBioMedicine 40 (2019): 349-362. http://dx.doi.org/10.1016/j.ebiom.2019.01.017.
    10.1016/j.ebiom.2019.01.017
  17. Rodrigues, Joana G.; Balmaña, Meritxell; Macedo, Joana A.; Poças, Juliana; (...); Magalhães, Ana; Gomes, Catarina; Mereiter, Stefan; Reis, Celso A.. "Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis". Cellular Immunology 333 (2018): 46-57. http://dx.doi.org/10.1016/j.cellimm.2018.03.007.
    10.1016/j.cellimm.2018.03.007
  18. Mereiter, Stefan; Polom, Karol; Williams, Coralie; Polonia, Antonio; Guergova-Kuras, Mariana; Karlsson, Niclas; Roviello, Franco; Magalhães, Ana; Reis, Celso. "The Thomsen-Friedenreich Antigen: A Highly Sensitive and Specific Predictor of Microsatellite Instability in Gastric Cancer". Journal of Clinical Medicine 7 9 (2018): 256. http://dx.doi.org/10.3390/jcm7090256.
    10.3390/jcm7090256
  19. Zhang, Haiying; Freitas, Daniela; Kim, Han Sang; Fabijanic, Kristina; (...); Magalhães, Ana; (...; Celso A. Reis; David Lyden. "Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation". Nature Cell Biology 20 3 (2018): 332-343. http://dx.doi.org/10.1038/s41556-018-0040-4.
    10.1038/s41556-018-0040-4
  20. Gomes, Joana; Mereiter, Stefan; Magalhães, Ana; Reis, Celso A.. "Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries". Cancer Cell 32 5 (2017): 544-545. http://dx.doi.org/10.1016/j.ccell.2017.10.010.
    10.1016/j.ccell.2017.10.010
  21. Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis". Cancer Cell 31 6 (2017): 733-735. http://dx.doi.org/10.1016/j.ccell.2017.05.012.
    10.1016/j.ccell.2017.05.012
  22. Ferreira, José Alexandre; Magalhães, Ana; Gomes, Joana; Peixoto, Andreia; Gaiteiro, Cristiana; Fernandes, Elisabete; Santos, Lúcio Lara; Reis, Celso A.. "Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics". Cancer Letters 387 (2017): 32-45. http://dx.doi.org/10.1016/j.canlet.2016.01.044.
    10.1016/j.canlet.2016.01.044
  23. Santos, Sofia N.; Junqueira, Mara S.; Francisco, Guilherme; Vilanova, Manuel; Magalhães, Ana; Baruffi, Marcelo Dias; Chammas, Roger; et al. "O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer". Oncotarget 7 50 (2016): http://dx.doi.org/10.18632/oncotarget.13192.
    10.18632/oncotarget.13192
  24. Mereiter, Stefan; Magalhães, Ana; Adamczyk, Barbara; Jin, Chunsheng; Almeida, Andreia; Drici, Lylia; Ibáñez-Vea, Maria; et al. "Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer". Biochimica et Biophysica Acta (BBA) - General Subjects 1860 8 (2016): 1795-1808. http://dx.doi.org/10.1016/j.bbagen.2015.12.016.
    10.1016/j.bbagen.2015.12.016
  25. Coelho, Elisabete; Magalhães, Ana; Dinis-Ribeiro, Mário; Reis, Celso A.. "CORRESPONDING AUTHOR: Mecanismos Moleculares de Adesão e Colonização da Mucosa Gástrica pela Helicobacter pylori e suas Implicações Clínicas". Acta Médica Portuguesa 29 7-8 (2016): 476. http://dx.doi.org/10.20344/amp.6651.
    10.20344/amp.6651
  26. Duarte, Henrique; Freitas, Daniela; Gomes, Catarina; Gomes, Joana; Magalhães, Ana; Reis, Celso. "Mucin-Type O-Glycosylation in Gastric Carcinogenesis". Biomolecules 6 3 (2016): 33. http://dx.doi.org/10.3390/biom6030033.
    10.3390/biom6030033
  27. Mereiter, Stefan; Magalhães, Ana; Adamczyk, Barbara; Jin, Chunsheng; Almeida, Andreia; Drici, Lylia; Ibáñez-Vea, Maria; et al. "Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4". Data in Brief 7 (2016): 814-833. http://dx.doi.org/10.1016/j.dib.2016.03.022.
    10.1016/j.dib.2016.03.022
  28. Magalhães, Ana; Rossez, Yannick; Robbe-Masselot, Catherine; Maes, Emmanuel; Gomes, Joana; Shevtsova, Anna; Bugaytsova, Jeanna; Borén, Thomas; Reis, Celso A.. "Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep25575.
    10.1038/srep25575
  29. Magalhães, Ana; Mereiter, Stefan; Reis, Celso. "Reciprocal Modulation of Terminal Sialylation and BisectingN-Glycans: A New Axis of Cancer-Cell Glycome Regulation?". Journal of Biological Chemistry 291 15 (2016): 8308-8308. http://dx.doi.org/10.1074/jbc.l116.722462.
    10.1074/jbc.l116.722462
  30. Mereiter, Stefan; Balmaña, Meritxell; Gomes, Joana; Magalhães, Ana; Reis, Celso A.. "CORRESPONDING AUTHOR: Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer". Frontiers in Oncology 6 (2016): http://dx.doi.org/10.3389/fonc.2016.00055.
    10.3389/fonc.2016.00055
  31. Gonçalves, Inês C.; Magalhães, Ana; Costa, Ana M.S.; Oliveira, José R.; Henriques, Patrícia C.; Gomes, Paula; Reis, Celso A.; Martins, M. Cristina L.. "Bacteria-targeted biomaterials: Glycan-coated microspheres to bind Helicobacter pylori". Acta Biomaterialia 33 (2016): 40-50. http://dx.doi.org/10.1016/j.actbio.2016.01.029.
    10.1016/j.actbio.2016.01.029
  32. Magalhães, A.; Mereiter, S.; Reis, C.. "Reciprocal modulation of terminal sialylation and bisecting N-glycans: A new axis of cancer-cell glycome regulation?". Journal of Biological Chemistry 291 15 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964577472&partnerID=MN8TOARS.
    10.1074/jbc.L116.722462
  33. Campos, Diana; Freitas, Daniela; Gomes, Joana; Magalhães, Ana; Steentoft, Catharina; Gomes, Catarina; Vester-Christensen, Malene B.; et al. "Probing the O-Glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery". Molecular & Cellular Proteomics 14 6 (2015): 1616-1629. http://dx.doi.org/10.1074/mcp.m114.046862.
    Published • 10.1074/mcp.m114.046862
  34. Magalhães, A.; Marcos-Pinto, R.; Nairn, A.V.; dela Rosa, M.; Ferreira, R.M.; Junqueira-Neto, S.; Freitas, D.; et al. "Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 9 (2015): 1928-1939. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940455366&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.07.001
  35. Campos, D.; Freitas, D.; Gomes, J.; Magalhães, A.; Steentoft, C.; Gomes, C.; Vester-Christensen, M.B.; et al. "Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery". Molecular and Cellular Proteomics 14 6 (2015): 1616-1629. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930470850&partnerID=MN8TOARS.
    10.1074/mcp.M114.046862
  36. Parreira, P.; Shi, Q.; Magalhaes, A.; Reis, C.A.; Bugaytsova, J.; Borén, T.; Leckband, D.; Martins, M.C.L.. "Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand". Journal of the Royal Society Interface 11 101 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84921665680&partnerID=MN8TOARS.
    10.1098/rsif.2014.1040
  37. Ruvoën-Clouet, N.; Magalhaes, A.; Marcos-Silva, L.; Breiman, A.; Figueiredo, C.; David, L.; Pendu, J.L.. "Increase in genogroup II.4 norovirus host spectrum by CagA-positive helicobacter pylori infection". Journal of Infectious Diseases 210 2 (2014): 183-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903978180&partnerID=MN8TOARS.
    10.1093/infdis/jiu054
  38. Amorim, I.; Freitas, D.P.; Magalhães, A.; Faria, F.; Lopes, C.; Faustino, A.M.; Smet, A.; et al. "A comparison of Helicobacter pylori and non-Helicobacter pylori Helicobacter spp. Binding to Canine Gastric Mucosa with Defined Gastric Glycophenotype". Helicobacter 19 4 (2014): 249-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904629577&partnerID=MN8TOARS.
    10.1111/hel.12125
  39. Rossez, Y.; Gosset, P.; Boneca, I.G.; Magalhães, A.; Ecobichon, C.; Reis, C.A.; Cieniewski-Bernard, C.; et al. "The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa". Journal of Infectious Diseases 210 8 (2014): 1286-1295. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910020633&partnerID=MN8TOARS.
    10.1093/infdis/jiu239
  40. Pinho, S.S.; Carvalho, S.; Marcos-Pinto, R.; Magalhães, A.; Oliveira, C.; Gu, J.; Dinis-Ribeiro, M.; et al. "Gastric cancer: Adding glycosylation to the equation". Trends in Molecular Medicine 19 11 (2013): 664-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886951831&partnerID=MN8TOARS.
    10.1016/j.molmed.2013.07.003
  41. Gonçalves, I.C.; Magalhães, A.; Fernandes, M.; Rodrigues, I.V.; Reis, C.A.; Martins, M.C.L.. "Bacterial-binding chitosan microspheres for gastric infection treatment and prevention". Acta Biomaterialia 9 12 (2013): 9370-9378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887160912&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.07.034
  42. Pinho, S.S.; Figueiredo, J.; Cabral, J.; Carvalho, S.; Dourado, J.; Magalhães, A.; Gärtner, F.; et al. "E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and v". Biochimica et Biophysica Acta - General Subjects 1830 3 (2013): 2690-2700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873589547&partnerID=MN8TOARS.
    10.1016/j.bbagen.2012.10.021
  43. Parreira, P.; Magalhães, A.; Reis, C.A.; Borén, T.; Leckband, D.; Martins, M.C.L.. "Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori". Acta Biomaterialia 9 11 (2013): 8885-8893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885052038&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.06.042
  44. Nolte, S.; de Castro Damasio, D.; Baréa, A.C.; Gomes, J.; Magalhães, A.; Mello Zischler, L.F.C.; Stuelp-Campelo, P.M.; et al. "BJcuL, a lectin purified from Bothrops jararacussu venom, induces apoptosis in human gastric carcinoma cells accompanied by inhibition of cell adhesion and actin cytoskeleton disassembly". Toxicon 59 1 (2012): 81-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-81255167365&partnerID=MN8TOARS.
    10.1016/j.toxicon.2011.10.012
  45. Pinto, R.; Carvalho, A.S.; Conze, T.; Magalhães, A.; Picco, G.; Burchell, J.M.; Taylor-Papadimitriou, J.; et al. "Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation". Journal of Cellular and Molecular Medicine 16 7 (2012): 1474-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863091545&partnerID=MN8TOARS.
    10.1111/j.1582-4934.2011.01436.x
  46. Camilo, V.; Barros, R.; Sousa, S.; Magalhães, A.M.; Lopes, T.; Santos, A.M.; Pereira, T.; et al. "Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells". Carcinogenesis 33 10 (2012): 1985-1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865579254&partnerID=MN8TOARS.
    10.1093/carcin/bgs233
  47. Gomes, J.; Magalhães, A.; Michel, V.; Amado, I.F.; Aranha, P.; Ovesen, R.G.; Hansen, H.C.B.; et al. "Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis". Toxicological Sciences 126 1 (2012): 60-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857962109&partnerID=MN8TOARS.
    10.1093/toxsci/kfr329
  48. Gomes, J.; Magalhães, A.; Carvalho, A.S.; Hernandez, G.E.; Papp, S.L.; Head, S.R.; Michel, V.; et al. "Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: Synergistic effect with Helicobacter pylori infection". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862232085&partnerID=MN8TOARS.
    10.1371/journal.pone.0038353
  49. Parreira, P.; Magalhaes, A.; Gonaçalves, I.C.; Gomes, J.; Vidal, R.; Reis, C.A.; Leckband, D.E.; Martins, M.C.L.. "Effect of surface chemistry on bacterial adhesion, viability, and morphology". Journal of Biomedical Materials Research - Part A 99 A 3 (2011): 344-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055008019&partnerID=MN8TOARS.
    10.1002/jbm.a.33178
  50. Marcos, N.T.; Bennett, E.P.; Gomes, J.; Magalhaes, A.; Gomes, C.; David, L.; Dar, I.; et al. "ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues". Frontiers in Bioscience - Elite 3 E 4 (2011): 1443-1455. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053586749&partnerID=MN8TOARS.
  51. Carvalho, A.S.; Harduin-Lepers, A.; Magalhães, A.; Machado, E.; Mendes, N.; Costa, L.T.; Matthiesen, R.; et al. "Differential expression of a-2,3-sialyltransferases and a-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells". International Journal of Biochemistry and Cell Biology 42 1 (2010): 80-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-70649087034&partnerID=MN8TOARS.
    10.1016/j.biocel.2009.09.010
  52. Magalhes, A.; Ismail, M.N.; Reis, C.A.. "Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: Glycoproteomic strategies". Expert Review of Proteomics 7 3 (2010): 307-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953604728&partnerID=MN8TOARS.
    10.1586/epr.10.18
  53. Magalhães, A.; Reis, C.A.. "Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors". Brazilian Journal of Medical and Biological Research 43 7 (2010): 611-618. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954695213&partnerID=MN8TOARS.
    10.1590/S0100-879X2010007500049
  54. Gomes, J.; Marcos, N.T.; Berois, N.; Osinaga, E.; Magalhães, A.; Pinto-de-Sousa, J.; Almeida, R.; Gärtner, F.; Reis, C.A.. "Expression of UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma". Journal of Histochemistry and Cytochemistry 57 1 (2009): 79-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149199902&partnerID=MN8TOARS.
    10.1369/jhc.2008.952283
  55. Pinho, S.S.; Reis, C.A.; Paredes, J.; Magalhães, A.M.; Ferreira, A.C.; Figueiredo, J.; Xiaogang, W.; et al. "The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin". Human Molecular Genetics 18 14 (2009): 2599-2608. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649859659&partnerID=MN8TOARS.
    10.1093/hmg/ddp194
  56. Magalhães, A.; Marcos, N.T.; Carvalho, A.S.; David, L.; Figueiredo, C.; Bastos, J.; David, G.; Reis, C.A.. "Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells". FEMS Immunology and Medical Microbiology 56 3 (2009): 223-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650763171&partnerID=MN8TOARS.
    10.1111/j.1574-695X.2009.00569.x
  57. Magalhães, A.; Gomes, J.; Ismail, M.N.; Haslam, S.M.; Mendes, N.; Osório, H.; David, L.; et al. "Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa". Glycobiology 19 12 (2009): 1525-1536. http://www.scopus.com/inward/record.url?eid=2-s2.0-71049182586&partnerID=MN8TOARS.
    10.1093/glycob/cwp131
  58. Marcos, N.T.; Magalhães, A.; Ferreira, B.; Oliveira, M.J.; Carvalho, A.S.; Mendes, N.; Gilmartin, T.; et al. "Helicobacter pylori induces ß3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x". Journal of Clinical Investigation 118 6 (2008): 2325-2336. http://www.scopus.com/inward/record.url?eid=2-s2.0-45649085812&partnerID=MN8TOARS.
    10.1172/JCI34324
Magazine article
  1. Magalhães, Ana. "Com doces também se enganam as bactérias", As Artes entre as Letras, 2010

Intellectual property

Patent
  1. Celso A. Reis; Stefan Mereiter; Magalhães, Ana; Karol Polom; Franco Roviello. 2019. "Antigen biomarker of microsatellite instability".
    Pending
  2. M. Cristina L. Martins; Inês C. Gonçalves; Paula Gomes; José R. Oliveira; Celso A. Reis; Magalhães, Ana. 2013. "Microspheres".
    Expired
Provisional application for patent
  1. 2022. "Heparan Sulfate Proteoglycan form of Syndecan-4 as Extracellular Vesicle associated Biomarker of Poor Survival and Organ Tropism".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 Deciphering glycosaminoglycan biosynthetic pathways and biological roles in cancer i3S Annual Meeting, 2023
(Portugal)
2023/09 Syndecan-4 - a maestro of gastric cancer cell invasion and intercellular communication Joint Meeting of the German Society for Matrix Biology and the Italian Society for the Study of Connective Tissues, Münster,
(Germany)
2023/09 Aberrant glycosylation in gastric cancer: novel molecular mechanisms controlling disease progression 7th Latin American Glycobiology Congress - CIDC – UAEM
(Mexico)
2023/09 Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival Workshop Porto Comprehensive Cancer Center Raquel Seruca
(Portugal)
2023/06 Mind the GAGs in gastric cancer 15th Jenner Glycobiology and Medicine symposium
(Portugal)
2023/05 Mind the GAGs in gastric cancer 29th Porto Cancer Meeting
2023/01 Mind the GAGs in gastric Cancer 14th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 14
(Portugal)
2023 Syndecan-4 is a maestro of gastric cancer cell invasion and intercellular communication 89th Harden Conference - Proteoglycans: Matrix Master Regulators, Biochemical Society Meeting
(United Kingdom)
2021/04/27 Exostosin-like 2 Abrogation Promotes Heparan Sulfate Biosynthesis and Switches Cancer Cell Signalling Towards an Invasive Phenotype Experimental Biology 2021 (ASBMB)
American Society for Biochemistry and Molecular Biology
2021 Exostosin-like 2 and Exostosin-like 3 Modulate Cancer Cells‘ GAGosylation and Malignant Phenotype INNOGLY-ECI-WG3-2021: Young Glyco-Scientists on stage
2021 Novel insights on Heparan Sulfate Proteoglycans biosynthetic pathways and their functional relevance on cancer. INNOGLY Meeting: GlycosAminoGlycans: What remains to be solved
(Crete, Greece)
2021 Translating the glycan code of extracellular vesicles in gastric cancer cell communication First Meeting of the Portuguese Network on Extracellular Vesicles
(Porto, Portugal)
2019/10/25 Uncovering Heparan Sulfate ProteoGlycans biosynthetic pahways and functional relevance in Gastric Cancer INNOGLY 1st Symposium
COST (Spain)
2019/10/23 Cancer Cell-derived Extracellular Vesicles carry tumour-associated glycan epitopes INOGGLY 1st Symposium
COST (Santiago de Compostela, Spain)
2019/09/03 O-glycans truncation shape cancer cell signalling and communication 13th International Meeting of the Portuguese Carbohydrate group
SPQ (Portugal)
2019 Heparan Sulfate ProteoGlycans roles in cancer cell signalling and communication i3S PI Seminar Series
2018/11/29 Cell surface heparan sulfate proteoglycans as novel key players in gastric cancer 7th i3S Annual Meeting
(Portugal)
2017/11 Extracellular matrix and Syndecan-4 dynamics in gastric cancer 6th i3S Annual Meeting
(Portugal)
2017/09 The role of glycosylation in the modulation of cancer cell aggressiveness 24th International Symposium On Glycoconjugates
(Jeju, South Korea)
2017/07 Glycoproteomic strategies for the identification of novel biomarkers in gastric cancer Mucins in Health and Disease
(Cambridge, United Kingdom)
2017/07 Glycosylation in cancer: glycomic strategies for characterization of molecular functions and biomarker applications European Carbohydrate Symposium
(Barcelona, Spain)
2016/11 The role of the glycoproteome alterations in gastric cancer and its clinical applications Meeting Of The Society For Glycobiology
(New Orleans, United States)
2016/06 Glycosyltransferases in Cancer: the role in gastric carcinogenesis and in cancer progression GlycoT 2016
(Toronto, Canada)
2016 The sweet receptors of Helicobacter pylori: decoding the pathways underlying gastric glycophenotype modulation i3S Pos-doc Seminar Series
2015/09 Role of glycans in gastric cancer: functional and biomarker applications 23rd International Symposium On Glycoconjugates
(Split, Croatia)
2014/11 Role of glycans in gastric cancer development and progression American Society for Glycobiology & The Japanese Society Carbohydrate Research 2014 - Joint Annual Meeting
(Honolulu, Hawai, United States)
2014/06 Modulation of the gastric mucosal glycosylation pathways by Helicobacter pylori chronic infection GLYCO-T 2014 9th International Symposium on Glycosyltransferases
(Porto, Portugal)
2012/07 Helicobacter pylori switches the host cells glycosylation pathways to remodel the gastric mucosa glycophenotype 10th International Workshop on Pathogenesis and Host Response in Helicobacter infections
(Helsingor, Denmark)
2010/11 Fut2-null mice display an altered gastric mucosa glycosylation profile and modified Helicobacter pylori adhesion 2010 Annual Conference of the Society for Glycobiology
(St Pete Beach, United States)
2010/07 Fut2-null mice display an altered gastric mucosa glycosylation profile and modified Helicobacter pylori adhesion. 9th International Workshop on Pathogenesis and Host Response in Helicobacter Infections
(Helsingor, Denmark)
2009/10 Fut2-null mice show altered glycosylation in the gastric mucosa and modified Helicobacter pylori adhesion Proceedings of the 5th International Congress on Computational Mechanics and Simulation
(Costa da Caparica, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Unravelling the impact of Heparan Sulfate profiles in Receptor Tyrosine Kinase activation using gastric cancer as model
Supervisor of Ana Raquel Ribeiro
 Mestrado em Medicina e Oncologia Moleculares (FMUP) (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/01/01 - Current Decoding Heparan Sulfate unique structural epitopes involved in cancer cell signalling. REF:2020.06412.BD
Supervisor of Catarina Marques Gonçalves
 Doctoral Program in Molecular and Cell Biology (MCbiology PhD program) (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/01/01 - 2024/01 Unravelling the role of Heparan Sulfate Proteoglycans in cell communication and gastric cancer progression
Supervisor of Juliana Poças Almeida
 Programa doutoral em Patologia e Genética Molecular (PhD)
University of Porto - Institute of Biomedical Sciences, Portugal
2022 - 2023 Establishment of a CRISPR/Cas9 activation (CRISPRa) methodology to study Sialyl Lewis X role in malignant features of gastrointestinal cancer cells
Co-supervisor
 Biochemistry (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2023 Premalignant and early malignant gastrointestinal tract lesions treated with Endoscopic submucosal dissection: defining the role of glycans in modulating tumorigenic potential
Co-supervisor
 Docoral program in Medicine (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2020/02/01 - 2020/11/13 Molecularly assembled matrices as platforms for studying cancer cells
Co-supervisor of João Telmo Silva Vieira
 Master (Master)
Universidade do Porto - Faculdade de Engenharia, Portugal
2016 - 2020/03/04 Impact of host glycosylation in tuberculosis
Co-supervisor of Kaori Levy da Fonseca
Cellular and Molecular Biology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/01 - 2019/10/18 Bio-mechanical functions of proteoglycans in the gastric cancer microenvironment.
Supervisor of Catarina Marques Gonçalves
 Biochemistry Master (Master)
University of Porto - Faculty of Sciences, Portugal
2015 - 2019/07/03 Unravelling exosomes glycosylation for early detection of gastric cancer and therapeutic applications
Co-supervisor of Daniela Freitas
 BiotechHealth (PhD)
University of Porto - Institute of Biomedical Sciences, Portugal
2017 - 2018/11/13 Extracellular Matrix-Glycan Dynamics in Gastric Cancer
Supervisor of Mariana Ferreira
 Integrated Master in Biomedical Engineering (Master)
Universidade do Minho, Portugal
2013 - 2017/03/06 Characterization of Gastric Cancer Glycosylation Profile for the Discovery of Biomarkers
Co-supervisor of Stefan Mereiter
 Ciências Biomédicas (PhD)
University of Porto - Institute of Biomedical Sciences, Portugal
2014 - 2015/11/16 The role of syndecan-4 in gastric cancer cell biology
Supervisor of Tiago Silva
 Master in Molecular Oncology (Master)
University of Porto - Institute of Biomedical Sciences, Portugal
2014 - 2015/07/31 Infeção por Helicobacter pylori: mecanismos moleculares de adesão e colonização da mucosa gástrica
Co-supervisor of Elisabete Coelho
 Mestrado Integrado em Medicina (Master)
University of Porto - Medical Faculty, Portugal
2012 - 2013/07/22 Chitosan microspheres for Helycobacter pylori infection treatment: a study using gastric mucosa models.
Co-supervisor of Ana Margarida Costa
 Mestrado Integrado em Bioengenharia (Master)
Universidade do Porto - Faculdade de Engenharia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024 - Current 7th Iberian Carbohydrate Meeting, Sitges (Barcelona), organizado pelos grupos de carbohidratos da Real Sociedad Española de Química (RSEQ) e Sociedade Portuguesa de Química (SPQ). (2024)
2023 - Current 15th Jenner Glycobiology and Medicine symposium, junho, i3S Porto. (2023)
Congress (Member of the Organising Committee)
2023 - Current XXIX Porto Cancer Meeting, maio, i3S Porto. (2023)
Conference (Member of the Organising Committee)
2020/10/08 - 2020/10/09 INNOGLY WG1-WG3 Joint Meeting: “Glycosylation in Cancer and Tumour Immunology” (2020/10/08 - 2020/10/09)
Conference (Co-organisor)
 University of Porto - i3S, Portugal
2019/01/01 - 2019/09/05 GLUPOR 13 - 13th International Meeting of the Portuguese Carbohydrate Group (2019/09/03 - 2019/09/05)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2014 9th International Symposium on Glycosyltransferases (2014), Portugal. (2014 - 2014)
Meeting (Member of the Organising Committee)
 University of Porto - IPATIMUP, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Unravelling heparan sulfate proteoglycans role in cell communication and gastric cancer progression
Supervisor
 Juliana Poças Almeida (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 Innovative Nanoparticles for Targeted Therapy Delivery in Gastrointestinal Cancer
Thesis Member
 Francisca Oliveira de Mesquita Diniz (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/28 Molecular Characterization of the adhesion and pathogenicity mechanisms of gastric non-Helicobacter pylori Helicobacter species in humans
(Thesis) Arguer
 Rita Santos Matos (PhD)
Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 Exploring the impact of mutant KRAS on epithelial-fibroblasts interactions during colorectal cancer initiation and progression
Thesis Member
 Patrícia Dias Carvalho (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 CyanoEV: characterizing Cyanobacterial Extracellular Vesicles, envisioning technological applications
Thesis Member
 Steeve da Silva Lima (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/18 Uncovering Heparan Sulfate ProteoGlycans biosynthetic pathways and functional relevance in gastric cancer
Supervisor
 Catarina Marques Gonçalves (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2018/12/13 Bladder cancer glycome and glycoproteome microenvironmental: the role of oxygen and glucose
(Thesis) Main arguer
 Marta Filipa Relvas dos Santos (Master)
University of Porto - Faculty of Sciences, Portugal
2018/11/13 Extracellular matrix - glycan dynamics in gastric cancer
Supervisor
 Mariana Ferreira (Master)
Universidade do Minho, Portugal
2018/10/08 Disclosing (epi)genetic mechanisms with potential value as predictive markers of therapy response in gastric cancer
(Thesis) Main arguer
 Sara Teles (Master)
Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/12/06 Glycoproteomic characterization of advanced bladder cancer towards novel therapies
(Thesis) Main arguer
 Sofia Cotton (Master)
Universidade de Aveiro, Portugal
2015/11/16 The role of syndecan-4 in gastric cancer cell biology
Supervisor
 Tiago Silva (Master)
University of Porto - Institute of Biomedical Sciences, Portugal
2015/10/16 A glycoproteomics discovery strategy for gastric cancer biomarkers
Thesis Member
 Diana Campos (PhD)
Faculty of Medicine, University of Porto, Portugal

Association member

Society Organization name Role
2020 - Current ANICT - Associação Nacional de Investigadores em Ciência e Tecnologia Association member
2019 - Current International Society for Extracellular Vesicles (ISEV)
2019 - Current PNEV- Portuguese Network of Extracellular Vesicles
2013 - Current Associação Portuguesa de Investigação em Cancro - ASPIC Association member
2011 - Current European Assocation for Cancer Research - EACR Association member
2010 - Current European Society of Clinical Microbiology and Infectious Diseases Association member
2008 - Current Society for Glycobiology Association member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Biochemistry II (Mestrado) Universidade do Porto Faculdade de Medicina Dentária, Portugal
2022 - Current Biophysic and Biochemistry (Licenciatura) Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Current Biochemistry (Licenciatura) Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Current Post-graduate course in Molecular signaling (MO16), Master in Oncology (Mestrado) University of Porto - Institute of Biomedical Sciences, Portugal
2015 - Current Post-graduate course in Medicine (MIMED) Unidade Curricular -Biomarcadores do cancro: bases moleculares e aplicações diagnósticas e terapêuticas" (1° Ciclo Medicina) (Mestrado integrado) University of Porto - Medical Faculty, Portugal
2015 - 2018 Post-graduate course of the University of Porto GABBA (Module of Oncobiology) (Doutoramento) University of Porto - Institute of Biomedical Sciences, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018/07/12 - 2018/07/12 Evaluation of research training - Biochemistry degree
Evaluator
 University of Porto - Faculty of Sciences, Portugal
2013/07/19 - 2013/07/19 Evaluation of research training - Biochemistry degree
Evaluator
 University of Porto - Faculty of Sciences, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Frontiers in Bioengineering and Biotechnology (2296-4185) Frontiers Media SA
2019 - Current Molecular Oncology (1878-0261) Wiley (John Wiley & Sons)
2019 - Current Expert Review of Proteomics (1744-8387) Informa UK (Taylor & Francis)
2019 - Current Experimental Cell Research (1090-2422) Elsevier
2018 - Current Glycoconjugate Journal (1573-4986) Springer-Verlag
2018 - Current Frontiers in Oncology (2234-943X) Frontiers Media SA
2017 - Current Scientific Reports (2045-2322) Springer Nature
2016 - Current PLoS ONE (1932-6203) Public Library of Science
2015 - Current Biomolecules (2218-273X) MDPI AG

Mentoring / Tutoring

Topic Student name
2019/01/01 - Current Targeting the cancer cell and extracellular matrix glycan's dynamics for impairment of tumour progression Isabel Ramos Antunes, PhD - Junior Researcher
2021 - 2022 Research Training of Biochemistry degree Raquel Ribeiro
2019/11 - 2020/12/31 Uncovering HSPG biosynthetic pathways in cancer cells Catarina Marques, Research Fellowship
2016/05/01 - 2018/12/31 Research Fellow - NORTE-01-045-FEDER-000029 Juliana Poças
2012 - 2013 Research training of Biochemistry degree Tiago Silva

Other jury / evaluation

Activity description Institution / Organization
2023 - Current First year evaluation comitee of Doctoral Program in Biomedical Sciences of Ana Sofia Ferreira Leite de Pinho Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2020 1st year evaluation of PhD degree in Biomedical Engineering, Engineering Faculty-University of Porto - FEUP Universidade do Porto - Faculdade de Engenharia, Portugal
2017 - 2017 1st year evaluation of PhD degree in Biomedical Sciences, Institute of Biomedical Sciences of University of Porto- ICBAS University of Porto - Institute of Biomedical Sciences, Portugal
Distinctions

Award

2019 FEBS Letters Award
Federation of European Biochemical Societies, United Kingdom
2016 Society for Glycobiology Travel award, New Orleans, USA
2012 EMBO Fellowship
EMBO, Germany
2007 Society for Glycobiology Travel award, Boston, USA
2005 Prémio Eng° Antonio de Almeida (2004/2005)-best classification on the graduate course of Biochemistry
Fundação Engenheiro António de Almeida, Portugal

Title

2015 Ambassador of Science program at i3S
University of Porto - i3S, Portugal