???global.info.a_carregar???
Paula Matos de Brito. Concluiu o(a) Doutoramento em PhD in Pharmacy, specialization domain ¿ Biochemistry em 2007 pelo(a) Universidade de Coimbra Faculdade de Farmácia, Doutoramento em Farmácia em 2007/12/17 pelo(a) Universidade de Coimbra Faculdade de Farmácia, Mestrado em Master in Cell Biology em 2003 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Ciências Farmacêuticas em 1999 pelo(a) Universidade de Coimbra Faculdade de Farmácia. É Investigador no(a) Universidade de Lisboa Faculdade de Farmácia. Publicou 14 artigos em revistas especializadas. Organizou 4 evento(s). Coorientou 1 tese(s) de doutoramento. Orientou 1 dissertação(ões) de mestrado. Recebeu 9 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Doutoramento em 2 projeto(s), Bolseiro de Iniciação Científica em 1 projeto(s), Investigador em 2 projeto(s) e Investigador responsável em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Biotecnologia Médica com ênfase em Biotecnologia Aplicada à Saúde. Please be aware that Paula had two CAREER BREAKS (in 2011 and 2017) due to pregnancies of her children and the respective periods of maternity leave (as mentioned on her professional activities). Thus, when determining her scientific productivity, please take into consideration that she has been a mother of two children, which naturally impacted on her productivity.No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Bioengineering; Biotechnology and Biochemistry - Biological Engineering; Health Sciences - Medical Genetics and Functional Genomics; Health Sciences - Microbiology; Infection; Immunology and Inflammation; Agricultural and Forest Sciences; Resveratrol; Cardiovascular diseases; Peroxynitrite; Oxidative stress; doenças cardiovasculares; Lipid oxidation; HIV; Cancer; antibodies; immunology; CAR-T; Immunogenecity; Inflammatory Bowel disease; Host factors; DNA-PKcs; Artificial Transcription Factors; Genome-wide screening; diphenyl diselenide; resveratrol; anthocyanins; apoptosis; GSH; antioxidant; atherosclerosis; hydrogen peroxyde; ROS; biomembranes; cancer; .
Read full resume ↓
Identification

Personal identification

Full name
Paula Matos de Brito

Citation names

  • Brito, Paula

Author identifiers

Ciência ID
7F16-5FB3-2395
ORCID iD
0000-0002-0105-6968

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2007/12/17
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Bioquímica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Papel do Resvertatrol no Contexto da Prevenção da Aterosclerose: Mecanismos Moleculares Envolvidos na Apoptose e Proliferação Celular" (THESIS/DISSERTATION)
2007
Concluded
 PhD in Pharmacy, specialization domain – Biochemistry (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Papel do resveratrol no contexto da prevenção da aterosclerose: mecanismos moleculares envolvidos na apoptose e proliferação celular" (THESIS/DISSERTATION)
 Approved with Distinction and Honours, highest pos
2003
Concluded
 Master in Cell Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Actividade antioxidante do resveratrol na oxidação de lipoproteínas humanas de baixa densidade e potencial protecção vascular" (THESIS/DISSERTATION)
 very good, highest possible classification
1999
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 grade 15 out of 20 (Top 5)
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - Current Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
(...)
2014/12/01 - 2019/02/28 Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2008/10/01 - 2013/01/31 Postdoc (Research) Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
2008/03/01 - 2008/09/30 Postdoc (Research) Universidade de Lisboa Associação para o Desenvolvimento e Ensino em Microbiologia, Portugal
2006/10/01 - 2007/08/30 Researcher (Research) Biocant Associação de Transferência de Tecnologia, Portugal
2002/10/01 - 2006/09/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/12/01 - 2006/05/31 Researcher (Research) INSERM U466, Toulouse, France
2000/04/01 - 2001/03/30 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/11/01 - 2000/12/31 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/05/01 - 1999/07/31 Research Trainee (Research) INSERM U466, Toulouse, France

Teaching in Higher Education

Category
Host institution 		Employer
2016/12/12 - 2019/02/28 Invited Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
2013/11/12 - 2016/11/11 Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal

Others

Category
Host institution 		Employer
2016/12/13 - 2017/04/04 Maternity leave Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2011/01/26 - 2011/05/31 Maternity leave Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
1998/01/01 - 1998/07/31 Extracurricular Research Trainee Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Contract

Designation Funders
2016 - 2018 Towards the development of innovative highly effective dual action anti-HIV peptides.
PTDC/QEQ-MED/4412/2014
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2016 Artificial Zinc-Finger transcription factors libraries: Identification of HIV-1 cellular restriction factors and Therapeutic application in HIV-1 infection. (VIH/SAU/20/2011)
VIH/SAU/20/2011
Principal investigator
Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2016 HIV-1 erradication by site-directed integration.
VIH/SAU/0013/2011
Researcher
Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/04/01 - 2014 PhageDuction: a new bacteriophage-based technology for efficient cell-targeted DNA delivery.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/125218/PT
Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2011 Screening the role of kinases/phosphatases in early stages of HIV-1 infection using shRNA-encoded lentiviral libraries.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/65346/PT
 Fundação para a Ciência e a Tecnologia
Concluded
2007/08/13 - 2011 Genome-wide screening with libraries of synthetic zinc-finger proteins capable to modulate host gene expression: Application in HIV-1 infection.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/71599/PT
Universidade de Lisboa - Centro de Patogénese Molecular Unidade de Retrovírus e Infecções Associadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2008 PROTECTION OF VASCULAR ENDOTHELIAL INFLAMMATION AND DYSFUNCTION BY RED WINE POLYPHENOLS: IMPLICATIONS TO ATHEROSCLEROSIS PREVENTION
info:eu-repo/grantAgreement/FCT/3599-PPCDT/83080/PT
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2004 Portuguese red wines: distribution of the main antioxidant components in lipoproteins and arterial wall after ingestion and protective vascular effects
POCTI/35019/AGR/2000
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2001 Phenolic compounds and antioxidant activity of Portuguese red wines: protection of human low density lipoproteins from oxidation
PraxisXXI/C/AGR/10239/98
Scientific Initiation Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Brito, Paula; Rita Acúrcio; Inês Raquel Iria; Ana Catarina Cunha Santos; Ana Barbas; Frederico Aires da Silva; Professor João Manuel Bras Goncalves; Miguel Cardoso. "P545 Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition". Paper presented in 13th Congress of the European Crohn’s and Colitis Organization, Vienna, Austria, 2018.
  2. Ana Catarina Godinho Santos; Sylvie Ferreira Rato; Professor João Manuel Bras Goncalves; Brito, Paula. "Modulation of HIV-1 LTR transcription by DNA-PKcs through cooperation with Tat and Vpr". Paper presented in XIX Congresso Nacional de Bioquímica, 2016.
  3. Ana Catarina Godinho Santos; Renato Alves; Francisco Pinto; Carlos Barbas; Professor João Manuel Bras Goncalves; Brito, Paula. "Identification of novel pharmacological tools against HIV-1 through artificial transcription factors libraries screening". Paper presented in XIX Congresso Nacional de Bioquímica, 2016.
  4. Brito, Paula; Sylvie Ferreira Rato; Carlos Barbas; Professor João Manuel Bras Goncalves. "Genome-wide screening to uncover new restriction celular factors against HIV-1 with artificial transcription factors". Paper presented in MicroBiotec 11, 2011.
  5. Brito, Paula; Sylvie Ferreira Rato; Ana Catarina Godinho Santos; Leonor Resende; André Ramos; Luis Ferreira Moita; Professor João Manuel Bras Goncalves. "DNA-PK, a co-factor in HIV-1 LTR-driven transcription". Paper presented in MicroBiotec 11, 2011.
  6. de Bem, Andreza Fabro; Brito, Paula; Calcerrada, Pablo. "Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell toxicity: a comparison with ebselen". Paper presented in 78th Congress of the European-Atherosclerosis-Society, 2010.
  7. Sylvie Ferreira Rato; Sara Maia; Brito, Paula; Leonor Resende; André Ramos; Carina Perreira; Luis Ferreira Moita; Professor João Manuel Bras Goncalves. "Novel hosts factors essential for HIV-1 replication: their importance in HIV-1 life cycle". Paper presented in 2010 Centennial Retroviruses Meeting, 2010.
  8. Sylvie Ferreira Rato; Leonor Resende; Brito, Paula; Carina Perreira; Luis Ferreira Moita; Professor João Manuel Bras Goncalves. "Functional shRNA screen reveals kinases and phosphatases essential for HIV-1 replication". Paper presented in Retroviruses Meeting, Cold Spring Harbor, 2009.
  9. Brito, Paula; Robert Devillard; Anne Nègre-Salvayre; Robert Salvayre; Nathalie Augé. "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells". Paper presented in 26e Congrès Annuel du Groupe de Réflexion sur la Recherche Cardiovasculaire, 2009.
  10. Brito, Paula; Núria Simões; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Resveratrol suppresses peroxynitrite-triggered mitochondrial apoptotic pathway in endothelial cells by up-regulating intracellular levels of Bcl-2". Paper presented in Meeting of the Society for Free Radical Research Europe, 2008.
  11. Joana Paixão; Núria Simões; Brito, Paula; Doutora Teresa do Carmo Pimenta Dinis e Silva; Doutora Leonor Martins de Almeida. "Cytoprotective effect of anthocyanins against peroxynitrite-promoted endothelial cells toxicity in relation to their antioxidant activities". Paper presented in European Meeting of the Society for Free Radical Research Europe, 2007.
  12. de Bem, Andreza Fabro; Brito, Paula; Doutora Teresa do Carmo Pimenta Dinis e Silva; João Rocha; Doutora Leonor Martins de Almeida. "A new role for diphenyl diselenide: Protection against peroxynitrite-mediated endothelial cell death". Paper presented in European Meeting of the Society for Free Radical Research Europe, 2007.
  13. Brito, Paula; Núria Simões; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Resveratrol prevents peroxynitrite-induced endothelial cells apoptosis by disrupting the mitochondrial pathway". Paper presented in European Meeting of the Society for Free Radical Research Europe, 2007.
  14. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Resveratrol prevents peroxynitrite-mediated cytotoxic effects via upregulation of intracellular GSH levels". Paper presented in XIII Biennial Meeting of the Society for Free Radical Research International, 2006.
  15. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Protection of resveratrol against vascular endohelial cell death triggered by peroxynitrite through a mitochondrial pathway". Paper presented in 2nd International Conference on Polyphenols and Health, 2005.
  16. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Resveratrol prevents peroxynitrite-induced endothelial cell death through a mitochondrial pathway". Paper presented in Oxygen Club Annual Meeting, 2005.
  17. Brito, Paula; Ana Carina Pais; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Antioxidant activities and potential vascular effects of anthocyanins extracts from varietal portugueses red wines". Paper presented in XIV Congresso Nacional de Bioquímica, 2004.
  18. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Does resveratrol have a protective role against proatherogenic activity of peroxynitrite?". Paper presented in 2nd Spanish and Portuguese Congress on Free Radicals, 2004.
  19. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Can resveratrol prevent peroxynitrite-mediated deleterious effects in the context of atherosclerosis". Paper presented in Free Radical School 2004 – Free Radical and Diseases: gene expression, cellular metabolism and pathophysiology, 2004.
  20. Brito, Paula. "Resveratrol prevents peroxynitrite-mediated oxidative modifications in LDL. Potential Vascular protective effects". Paper presented in 1st Luso-Spanish Congress on Free Radical/6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
  21. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Antioxidant activity and potential vascular protective effects of resveratrol". Paper presented in ” XIII Congresso Nacional de Bioquímica,, 2002.
  22. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Effect of resveratrol on endothelial cells viability and cellular cycle". Paper presented in XI th Biennial Meeting of the Society for Free Radical Research International, 2002.
  23. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "Resveratrol inhibits human LDL oxidation and suppresses cultured bovine endothelial cell proliferation". Paper presented in International Symposium on Reactive Oxygen species and Nitrogen species: Diagnostic, Preventive and Therapeutic Values, 2002.
  24. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "The antioxidant and potential vascular protective effects of resveratrol.". Paper presented in 5º congresso de Radicais Livres em Química, Biologia e Medicina, 2001.
  25. Brito, Paula; Doutora Leonor Martins de Almeida; Doutora Teresa do Carmo Pimenta Dinis e Silva. "How does resveratrol protect LDL against oxidation promoted by the physiological oxidants ferrylmyoglobin and peroxynitrite?". Paper presented in 27th FEBS meeting, 2001.
  26. Doutora Teresa do Carmo Pimenta Dinis e Silva; Brito, Paula; João Laranjinha; Doutora Leonor Martins de Almeida. "Antioxidant potential of resveratrol: interaction with high valence states of myoglobin". Paper presented in 10th Biennal Meeting of the International Society for Free Radical Research, 2000.
  27. Brito, Paula; Doutora Teresa do Carmo Pimenta Dinis e Silva; Doutora Leonor Martins de Almeida. "Interaction of resveratrol with physiological oxidants: inhibition of LDL oxidation". Paper presented in XII Congresso Nacional de Bioquímica, 2000.
  28. Doutora Teresa do Carmo Pimenta Dinis e Silva; José Custódio; Carla Cardoso; Brito, Paula; José Cavaleiro; Doutora Leonor Martins de Almeida. "Partitioning of TPP-PY in human plasma low density lipoproteins and potential toxicity". Paper presented in XI Congresso Nacional de Bioquímica, 1988.
Journal article
  1. Brito, P.M.; Devillard, R.; Nègre-Salvayre, A.; Almeida, L.M.; Dinis, T.C.P.; Salvayre, R.; Augé, N.. "Corrigendum to “Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells” (Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells (2009) 205(1) (126–134), (S002191500800779X), (10.1016/j.atherosclerosis.2008.11.011))". Atherosclerosis 285 (2019): 178-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064085733&partnerID=MN8TOARS.
    10.1016/j.atherosclerosis.2019.03.018
  2. Goncalves, J.; Santos, M.; Acurcio, R.; Iria, I.; Gouveia, L.; Matos Brito, P.; Catarina Cunha-Santos, A.; et al. "Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition". Alimentary Pharmacology & Therapeutics 48 5 (2018): 507-522. http://dx.doi.org/10.1111/apt.14808.
    10.1111/apt.14808
  3. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))". Redox Biology 14 (2018): 694-696. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS.
    10.1016/j.redox.2017.10.001
  4. Antunes, F.; Brito, P.M.. "Quantitative biology of hydrogen peroxide signaling". Redox Biology 13 (2017): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019465587&partnerID=MN8TOARS.
    10.1016/j.redox.2017.04.039
  5. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)". Redox Biology 13 (2017): 94-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032301&partnerID=MN8TOARS.
    10.1016/j.redox.2017.05.007
  6. Goncalves, J.; Matos de Brito, P.; Batista, A.; Feio, J.; Machado, F.; Aperta, J.; Ascensão, I.; et al. "Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies". Journal of Clinical Pharmacy and Therapeutics 42 2 (2016): 239-243. http://dx.doi.org/10.1111/jcpt.12477.
    Published • 10.1111/jcpt.12477
  7. Brito, P.M.; Antunes, F.. "Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins". Frontiers in Chemistry 2 OCT (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949283967&partnerID=MN8TOARS.
    10.3389/fchem.2014.00082
  8. Santa-Marta, Mariana; de Brito, Paula Matos; Godinho-Santos, Ana; Goncalves, Joao. "Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches.". Frontiers in immunology 4 (2013): 343-343.
    10.3389/fimmu.2013.00343
  9. de Bem, Andreza Fabro; Fiuza, Bianca; Calcerrada, Pablo; Brito, Paula M.; Peluffo, Gonzalo; Dinis, Teresa C. P.; Trujillo, Madia; et al. "Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: A comparison with ebselen". Nitric Oxide-Biology and Chemistry 31 (2013): 20-30.
    10.1016/j.niox.2013.03.003
  10. Rato, Sylvie; Maia, Sara; Brito, Paula M.; Resende, Leonor; Pereira, Carina F.; Moita, Catarina; Freitas, Rui P.; et al. "Novel HIV-1 Knockdown Targets Identified by an Enriched Kinases/Phosphatases shRNA Library Using a Long-Term Iterative Screen in Jurkat T-Cells". Plos One 5 2 (2010):
    10.1371/journal.pone.0009276
  11. Brito, Paula M.; Devillard, Raphael; Negre-Salvayre, Anne; Almeida, Leonor M.; Dinis, Teresa C. P.; Salvayre, Robert; Auge, Nathalie. "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells". Atherosclerosis 205 1 (2009): 126-134.
    10.1016/j.atherosclerosis.2008.11.011
  12. Brito, Paula M.; Simoes, Nuria F.; Almeida, Leonor M.; Dinis, Teresa C. P.. "Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2". Apoptosis 13 8 (2008): 1043-1053.
    10.1007/s10495-008-0235-4
  13. Brito, Paula M.; Mariano, Anabela; Almeida, Leonor M.; Dinis, Teresa C. P.. "Resveratrol affords protection against peroxynitrite-mediated endothelial cell death: A role for intracellular glutathione". Chemico-Biological Interactions 164 3 (2006): 157-166.
    10.1016/j.cbi.2006.09.007
  14. Brito, P; Almeida, LM; Dinis, TCP. "The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; Protection against LDL oxidation". Free Radical Research 36 6 (2002): 621-631.
    10.1080/10715760290029083
Thesis / Dissertation
  1. Brito, Paula. "Papel do resveratrol no contexto da prevenção da aterosclerose: mecanismos moleculares envolvidos na apoptose e proliferação celular". PhD, Universidade de Coimbra Faculdade de Farmácia, 2007.
  2. Brito, Paula. "Actividade antioxidante do resveratrol na oxidação de lipoproteínas humanas de baixa densidade e potencial protecção vascular". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2009/11/28 Identification of new cellular proteins essential for HIV-1 replication: the importance of kinases and phosphatases in HIV-1 life cycle Microbiotec09
(Vilamoura, Portugal)
2005/04/16 Resverastrol protects LDL and vascular endothelial cells against peroxynitrite-mediated oxidative toxicity 4th International Meeting Dietary Antioxidants, Trace Elements, Vitamins and Polyphenols – Functional and clinical aspects in humans
(Monastir, Tunisia)
2001/11/07 How does resveratrol protect LDL against oxidation promoted by the physiological oxidants ferrylmyoglobin and peroxynitrite? Euroconference 2nd International Meeting on Cellular Responses to Oxidative and Osmotic stress, sensing, signalling and gene expression
(povoa de varzim, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/02/01 - Current The impact of TCF1 in T-cell memory self-renewal and the effectiveness of armored CAR-T in solid tumors
Co-supervisor of Ana Margarida de Abreu Manuel
 Doutoramento em Farmácia, especialidade em Biotecnologia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2015/09/01 - 2016/07/31 Role of DNA-PKcs in HIV-1 LTR-mediated transcription
Supervisor
 master in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/11/23 - 2020/11/27 PhD Advanced Course - BioPharmaceuticals and Advanced Therapies. The Course on BioPharmaceuticals and Advanced Therapies is part of the PhD Programme in Pharmaceutical Sciences, and provides an overview of both classical and biotechnology derived medicinal products and on the pathways used for scientific advice, clinical trials and marketing authorizations in Europe. (2020/11/23 - 2020/11/27)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/10/01 - 2018/10/04 BioPharmaceuticals and Advanced Therapies (2018/11/01 - 2018/11/04)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/09/18 - 2017/09/26 Course: BioPharmaceuticals and Advanced Therapies. (2017/09/18 - 2017/09/26)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2015/09/18 - 2015/10/02 Course: BioPharmaceuticals and Advanced Therapies The Course on BioPharmaceuticals and Advanced Therapies is part of the PhD Programme in Medicines and Pharmaceutical Innovation (i3DU), provides an overview of both classical and biotechnology derived medicinal products and on the pathways used for scientific advice, clinical trials and marketing authorizations in Europe. Although the training program aimed at PhD students it welcomed the participation of external academic and scientific community members. (2015/09/28 - 2015/10/02)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2017/12/18 O papel do DNA-PKcs na transcrição mediada pelo promotor LTR do HIV-1
Supervisor
 MARIA INÊS DA COSTA CARDOSO CINTRÃO GONÇALVES (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/02/20 Novel anti-nucleolin antibodies for targeted cancer therapy
Thesis Member
 Sofia Pereira Constantino Romano (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/01/24 Modulation of HIV-1-Host Cell Pathwavs: from Virus Entry to Latency
Thesis Member
 Ana Catarina Taborda Godinho Santos (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
1999/11/01 - Current Sociedade Portuguesa de Bioquimica
1999/05/01 - Current Ordem dos Farmacêuticos membro

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/03/01 - 2019/05/31 Molecular Basis of Drug Action Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2013/11/13 - 2018/05/31 Human Pathophysiology and Pharmacology mestrado integrado em ciências farmacêuticas (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2013/11/13 - 2014/12/31 Prevention and Therapy mestrado integrado en ciências farmacêuticas (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2008/09/01 - 2009/09/30 Use of Artificial Transcription Factor Libraries in the identification of important cellular genes in inhibiting HIV-1 infectivity Joana Borges Pinto

Other jury / evaluation

Activity description Institution / Organization
2017/06/01 - Current Exam of course Project II of Integrated Master in Pharmaceutical Sciences. Ana Patrícia Vigarinho de Jesus Almeida (2017).Using cells as biosensors Faculty of Pharmacy University of Lisbon. Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/02/01 - Current Exam of the 1st year of PhD Program Susana Isabel Casaca Figueiredo Bandarra (2014). Caracterização do efeito da família APOBEC3 na infecção por HIV2: contributo para o desenvolvimento de novas terapêuticas. Faculty of Pharmacy University of Lisbon. Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/06/01 - Current Exam of course Project I of PhD program Ana Catarina Godinho Santos (2012).HIV entry and Calcium: surface connection or downstream reliance? Faculty of Pharmacy University of Lisbon. Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Other distinction

2013 Post-doc fellowship
2008 Post-doc fellowship
2008 Post-doc fellowship
2004 FEBS award
2002 Ph.D fellowship
2002 SPB award
2001 SPB award
2000 MSc fellowship
1999 BIC fellowship