Rita Gonçalves Sobral de Almeida (7F1F-7412-A2C3)

Curriculum Vitae

Rita Gonçalves Sobral de Almeida

As molecular microbiologist, and head of the Lab of Molecular Microbiology of Bacterial Pathogens (MolMicro) at UCIBIO since 2015, I developed strong expertise in molecular biology, S. aureus mutant construction, transcriptomic and genomic approaches, protein-protein interactions, cell wall and membrane analysis. The MolMicro lab studies S. aureus mechanisms of antibiotic resistance, cell wall physiology, biofilm formation, interspecies and host-pathogen interactions. I am also assistant Professor since 2015 at FCT NOVA, responsible for the subjects ¿Methods in Molecular Biology¿, ¿Applied Microbiology¿ and ¿Biofilms in chronic infections¿ in which I lecture over 100 undergraduate and Msc students, yearly. After a degree in Biotechnology, I obtained my Ph.D. in Molecular Biology (ITQB-NOVA) in 2006. I was invited researcher at the Lab of Professor Alexander Tomasz, expert in S. aureus cell wall, at Rockefeller University (NY) from 2002 to 2007. I was twice (2011 and 2015) awarded a young investigator research grant by the European Society of Clinical Microbiology and Infectious diseases (ESCMID). Since then, I was PI of 2 research grants and co-PI of 2 other, at National competitive calls and team member of over 10 financed projects. During the last decade I established collaborations with over 15 national and overseas research groups, in fundamental and complementary fields, and experts on S. aureus antibiotic resistance. All these collaborations are ongoing, some already resulted in published works and most in co-supervision of PhD or Msc students. I supervised 3 post-docs, 11 PhD Theses (5 ongoing), 27 Msc Theses (4 ongoing), 7 visiting students (COST, H2020 RISE, Erasmus) and over 40 undergraduates. I published 40 peer-reviewed papers (h-index:17, scopus; 20 Scholars), some in high impact journals (Nat Microbiol, PLOS Path, PLOS Gen, AAC,), 8 conference proceedings, over 40 oral and 60 poster communications. I am currently Academic Editor for PLOS One and evaluator of Research Grants and Post-doctoral fellowships for the Swiss National Foundation (SNF).

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Identification

Personal identification

Full name: Rita Gonçalves Sobral de Almeida
Gender: Female

Citation names

Rita G. Sobral

Author identifiers

Ciência ID: 7F1F-7412-A2C3
ORCID iD: 0000-0003-4533-7531

Email addresses

rgs@fct.unl.pt (Professional)

Addresses

Departamento de Ciências da Vida,. Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, 2829-516 , Caparica, Almada, Portugal (Professional)

Websites

https://ucibio.pt/people/rita-sobral (Scholar)

Knowledge fields

Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Advanced (C1)
French	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Beginner (A1)	Intermediate (B1)		Beginner (A1)
Italian	Beginner (A1)	Intermediate (B1)		Beginner (A1)

Education

	Degree	Classification
2006 Concluded	Doutoramento em Ciências Biológicas (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal "Modulating Staphylococcus aureus cell physiology through a murein ligase" (THESIS/DISSERTATION)	Aprovado por unanimidade
1998 Concluded	Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Stress response related genes in gram-positive bacteria" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2010/12/30 - 2014/12/31	Researcher (Research)	Centro de Recursos Microbiológicos, CREM, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2015/08/01 - Current	Assistant Professor (University Teacher)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Others

	Category Host institution	Employer
2023/01/01 - Current	Coordinator of the Master in Medical Microbiology	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

2015/01/01 - Current	Assistant Researcher - Head of the Laboratory of Molecular Microbiology of Bacterial Pathogens	Unidade de Ciências Biomoleculares Aplicadas, Portugal

2013/09/01 - 2013/11/01	Invited Professor - Mestrado integrado em Genética Molecular e Biomedicina	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

2012/02/01 - 2012/07/31	Invited Professor - Mestrado integrado em Engenharia do Ambiente e Engenharia Química e Bioquímica.	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

2006/12/01 - 2010/12/30	Post-doctoral fellow	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

2010/03/01 - 2010/08/31	Invited Adjunct Professor - Responsible for the Biochemistry Curricular Unit (Licenciatura em Engenharia Química)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal

2001/01/01 - 2006/11/22	Visiting PhD student - Laboratory of Microbiology (PI: A. Tomasz)	The Rockefeller University, United States

2001/01/01 - 2006/11/22	PhD Student - Laboratory of Molecular Genetics (PI: H. de Lencastre)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

1997/10/01 - 2000/12/31	Research student - Fellowship IBET 1999 and fellowship ITQB 2000	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

1996/07/01 - 1996/09/30	Erasmus Research trainee	Bangor University School of Electronic Engineering, United Kingdom

Projects

Grant

	Designation	Funders
2007/01/01 - 2010/05/01	A NEW STAPHYLOCOCCAL DCW ISLAND CARRYING MURF, DDLA AND A FTSW/RODA HOMOLOG: ROLES IN CELL WALL SYNTHESIS, CELL DIVISION AND DRUG RESISTANCE SFRH/BPD/28760/2006 Post-doc Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001/01/01 - 2005/01/01	Modulating Staphylococcus aureus cell physiology through a murein ligase SFRH/BD/3138/2000 PhD Student Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2022/01/01 - Current	DIGIAqua – Digitalizando a Aquacultura: da análise preditiva à plataforma fotónica inteligente PTDC/EEI-EEE/0415/2021 Researcher Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - Current	PROTEIOS - Protein Tunable Materials for Non-Invasive Sensing PTDC/CTM-CTM/3389/2021 Researcher REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - Current	StaphOUT - Fighting Staphylococcus aureus - Peptidoglycan amidation as a new target PTDC/BIA-MIC/31645/2017 Principal investigator REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Instituto para a Saúde e a Bioeconomia LA/P/0140/2020 10.54499/LA/P/0140/2020 Principal investigator Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade NOVA de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2023/12/31	Unidade de Ciências Biomoleculares Aplicadas UIDB/04378/2020 10.54499/UIDB/04378/2020 Principal investigator Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/12/31	Unidade de Ciências Biomoleculares Aplicadas UIDP/04378/2020 10.54499/UIDP/04378/2020 Principal investigator Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/01 - 2019/12	NANOMATERIALS-BASED INNOVATIVE ENGINEERING SOLUTION TO ENSURE SUSTAINABLE SAFEGUARD TO INDOOR AIR grant.690968 Researcher	European Commission
2015/01/01 - 2019/04/30	Microfluidics Liquid Crystal Based Bifuncional Bacterial Infeccion Sensor PTDC/FIS-NAN/0117/2014 Principal investigator REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/01 - 2017/12	Copper tolerance in Enterococcus faecium: unveiling the activity of a multicopper oxidase encoded by cueO gene and its gene transfer to Staphylococcus aureus 0000	Concluded
2013/07/01 - 2017/01/01	Amidation of the peptidoglycan of Gram-positive bacteria: an unexplored potential target for antibiotics PTDC/BIA-MIC/3195/2012 Researcher Centro de Recursos Microbiológicos, CREM, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Association of extracellular DNA to the Staphylococcus aureus surface: roles and mechanisms ESCMID project Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Concluded
2010/01/01 - 2013/06/30	Metabolic circuits in inflicted bacterial cell death PTDC/BIA-MIC/101375/2008 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Portugal: a pilot study focusing on an emerging public health concern Ref. P-99911 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação Calouste Gulbenkian Concluded
2008 - 2010	Regulatory networks on Staphylococcus aureus cell wall physiology POCTI/BIA-MIC/71168/2006 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Regulation of cell wall synthetic genes and enzymes in beta-lactam resistant Staphylococcus aureus POCTI/BIA-MIC/58416/2004 Research Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001 - 2004	Functional Genomics and High Resolution Molecular Typing of Methicillin Resistant Staphylococcus aureus (MRSA) FCG/47187 Research Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação Calouste Gulbenkian Concluded
2000 - 2004	Molecular evolution and molecular epidemiology of methicillin resistance in Staphylococcus aureus POCTI/ESP/34872/1999 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1997 - 1998	Stress response genes in gram-positive cocci PRAXIS XXI 2/2.1/BIO/1154/95 Scientific Initiation Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2019/10/01 - Current	Cost Action 18238 - Ocean4Biotech Cost Action 18238 Researcher REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Horizon 2020 Ongoing

Outputs

Publications

Book chapter	Portela, R.; Almeida, P.L.; Sobral, R.G.; Leal, C.R.. "S. aureus and E. coli Co-culture Growth Under Shear". 108-112. 2020. 10.1007/978-3-030-27701-7_23 Sobral, R.; Tomasz, A.. "The staphylococcal cell wall". 574-591. 2019.
Conference abstract	Gonçalves, Bárbara; Barreiro, Daniela S.; Rita G. Sobral; Pauleta, Sofia R.. Corresponding author: Pauleta, Sofia R.. "The role of the multicopper oxidase in copper homeostasis in gram positive pathogens". Paper presented in Congress of Microbiology and Biotechnology, Coimbra, 2019. Gonçalves, Bárbara; Barreiro, Daniela S.; Pauleta, Sofia R.; Rita G. Sobral. "Dealing with copper stress - multicopper oxidases in pathogenic Gram-positive bacteria". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, Porto, 2019.
Conference paper	Portela, R.; P.L. Almeida; Rita G. Sobral; C.R. Leal. "S. aureus and E. coli co-culture growth under shear". Paper presented in 7th Iberian Meeting on Rheology 2019 (IbeReo2019), Porto, 2019. Fernandes A.F.; L. Costa; J.R. Sousa; J. Zalocha; I.R. Grilo; Rita G. Sobral; S.P. Gaudencio; M.G. Almeida. "Biological activities of marine-derived actinomycetes: testing the aqueous extracellular phase of Streptomyces aculeolatus". Paper presented in 3rd International Congress of CiiEM Research and Innovation in Human and Health Sciences, 2019. Portela, R.; Franco, J.M.; Almeida, P.L.; Patrício, P.; Sobral, R.G.; Leal, C.R.. "Rheology of living cells". 2019. 10.1109/ENBENG.2019.8692466 Portela, R.; J.M. Franco; P. Patrício; P.L. Almeida; Rita G. Sobral; C.R. Leal. "Rotational and translational motion observed in Escherichia coli aggregates during shear". 2017. Portela, R.; J.M. Franco; P. Patrício; P.L. Almeida; Rita G. Sobral; C.R. Leal. "Living S. aureus bacteria rheology". Paper presented in XVIIth International Congress on Rheology (ICR2016), 2016. Franco, J.M.; P. Patricio; P.L. Almeida; R. Portela; Rita G. Sobral; C.R. Leal. "Cell necklaces behave as a soft glassy material". Paper presented in Proceedings of IbeReo2015, Coimbra, 2015. Portela, R.; P.L. Almeida; P. Patricio; T. Cidade; Rita G. Sobral; C.R. Leal. "Staphylococcus aureus strains rheology during growth". Paper presented in Ibereo 2013, Malaga, 2013. Portela, R.; M. Pereira; Rita Sobral; P.L. Almeida; C.R. Leal. "Bacterial growth screened by rheology.". Paper presented in Ibereo 2011 Conference - “Rheology trends: from nano to macro systems”, Caparica, 2011.
Conference poster	ARAÚJO, MARIANA; Faria, Nuno A.; Gonçalo, Margarida ; Nakonieczna, Joanna ; Torres, Carmen; Campanile, Floriana; Netto dos Santos, Katia; Rita G. Sobral; Miragaia, Maria. "Genomic profile of Staphylococcus aureus from Atopic Dermatitis collected worldwide". Paper presented in 34th European Congress of Clinical Microbiology & Infectious Diseases (34thECCMID), 2024. ARAÚJO, MARIANA; Faria, Nuno A.; Gonçalo, Margarida ; Nakonieczna, Joanna ; Torres, Carmen; Campanile, Floriana; Netto dos Santos, Katia; Rita G. Sobral; Miragaia, Maria. "Staphylococcus aureus from atopic dermatitis have specific genomic signatures". Paper presented in Microbiotec'23 - Congress of Microbiology and Biotechnology, 2023. Faria, Nuno A.; ARAÚJO, MARIANA; Joanna Nakonieczna; Rita G. Sobral; Miragaia, Maria. "Atopic Dermatitis microenvironment favours Staphylococcus aureus growth and promotes antibiotic resistance". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023. Sequeira, AR; Portela, RP; Dias, J.S.; Rita G. Sobral. "Role of Skf system of Staphylococcus aureus in inter-species interactions". Paper presented in 2nd Microbiome PT Summit, 2023. Costa-Camilo, Eduardo; Rita G. Sobral; Pinheiro, Carla. "Antimicrobial and antioxidant activity of cork polar extractives". Paper presented in 2nd Microbiome PT Summit, 2023. Santos, A; Gonçalves, Inês; Rita G. Sobral; Sá-Nogueira, Isabel. "Characterization of a Type I ABC Transporter in Staphylococcus aureus". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023. Cavaco, G.; Soares, SM; Grilo, Inês Ramos; Pina, AS; Roque, ACA; Marques, C; Miragaia, Maria ; Rita G. Sobral; Almeida, PL. "Liquid Crystal based bacterial infection biossensor". Paper presented in 28th International Liquid Crystal Conference (ILCC 2022), 2022. Cavaco G.; J. Saraiva; Portela, R.; C.R. Leal; R.G. Sobral; Almeida, P.L.. Corresponding author: Almeida, P.L.. "Treating Burn Wounds With Bacterial Cellulose". Paper presented in 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2022), 2022. Cavaco G.; A.C. Fanico; Gonçalves, B.V.; N. Faria; M. Miragaia; R.G. Sobral. Corresponding author: R.G. Sobral. "New factors of lysozyme resistance in Staphylococcus aureus associated with peptidoglycan amidation.". Paper presented in 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2022. B.V. Gonçalves; Cavaco G.; De Lencastre, H.; L.J. Mota; R.G. Sobral. Corresponding author: R.G. Sobral. "The role of peptidoglycan amidation in host immune response". Paper presented in 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2022. Ana P. C. Almeida; João Saraiva ; Raquel Portela; Maria Helena Figueiredo Godinho; Rita G. Sobral; Pedro Marques de Almeida. Corresponding author: Pedro Marques de Almeida. "Bacterial Cellulose Based Hydrogel For Wound Dressing Application". Paper presented in 3 rd Condensed Matter Physics National Conference, Lisbon, 2022. Portela, R.; M. Silva; B.V. Gonçalves; J.S. Dias; A. Rosato ; R.G. Sobral. Corresponding author: R.G. Sobral. "Skf System, a Promising New Bacteriocin System of Staphylococcus aureus". Paper presented in 5th Annual Texas Medical Center Antimicrobial Resistance & Stewardship Conference, 2022. Portela, Raquel; Oliveira, Ricardo N. S.; Tostão, Alicia; Gonçalves, Bárbara V.; Rita G. Sobral; Pauleta, Sofia R.. "Detoxification of toxic intermediates produced by oxygen reduction in human pathogens". Paper presented in MicroBioTec, 2021. Barreiro, Daniela S.; Oliveira, Ricardo N. S.; Gonçalves, Bárbara; Rita G. Sobral; Pauleta, Sofia R.. Corresponding author: Pauleta, Sofia R.. "Copper Proteins form Pathogenic Bacteria - Metal Homeostasis and Denitrification". Paper presented in International Workshop on Chemistry of Group 11 Elements, 2020. Gonçalves, B.V.; Portela, R.; R. Lobo; T.A. Figueiredo; Grilo, I.R.; A.M. Ludovice; De Lencastre, H.; J.S. Dias; R.G. Sobral. Corresponding author: R.G. Sobral. "Zooming in on MurT C-terminal domain – impact of specific residues on peptidoglycan amidation in S. aureus.". Paper presented in The Great Wall Symposium, 2019. Grilo, I.R.; C.A.C. Madeira; A.M. Ludovice; R.G. Sobral. Corresponding author: R.G. Sobral. "Molecular features of the GL-DNA interaction and effects on hydrolytic activity.". 2019. Cavaco G.; A.M. Ludovice; H. de Lencastre; R.G. Sobral. Corresponding author: R.G. Sobral. "Structural modifications in the peptidoglycan influence the autolytic system of S. aureus". Paper presented in The Great Wall Symposium, 2019. Luca Luppino; Grilo, I.R.; G. Fonseca; C. Rodrigues; R.G. Sobral; Gaudêncio, S.P.. "Deep sea actinomycetes from Estremadura Spur, Continental Portugal, targeted as antimicrobial agents.". Paper presented in XVI International Symposium on Marine Natural Products (XVI MaNaPro), 2019. Costa, Clarinda; Guilherme Morais; Miguel Mates; Branco, Paula S.; Susana P. Gaudêncio; Rita G. Sobral; Grilo, Inês R.; et al. "Dry Powder Formulations for Antibiotic Pulmonary Delivery". Paper presented in 6th Portuguese Young Chemists Meeting, 2018. Miguel Mateus ; Guilherme Morais; Costa, Clarinda; Branco, Paula S.; Grilo, Inês R.; Rita G. Sobral; Susana P. Gaudêncio; Bonifácio, Vasco D.B.; Aguiar-Ricardo, Ana. "One-Pot reaction: A sustainable and green approach for drug modification". Paper presented in 6th Portuguese Young Chemists Meeting, 2018. Costa, Clarinda; Guilherme Morais; Miguel Mateus ; Branco, Paula S.; Susana P. Gaudêncio; Rita G. Sobral; Grilo, Inês R.; et al. "Development of Dry Powder Formulations Containing Antibacterial Compounds". Paper presented in 12th International Symposium on Supercritical Fluids, 2018.
Journal article	Selvi C. Ersoy; Richard A. Proctor; Warren E. Rose; Wessam Abdelhady; Sook-Ha Fan; Sabrina L. Madrigal; Ahmed M. Elsayed; et al. "Sensitizing methicillin-resistant Staphylococcus aureus (MRSA) to cefuroxime: the synergic effect of bicarbonate and the wall teichoic acid inhibitor ticlopidine". Antimicrobial agents chemotherapy (2024): Accepted Soares, Maria Simone; Sobral, Rita Gonçalves; Santos, Nuno; Marques, Carlos; Almeida, Pedro Lúcio. "Liquid Crystal-based Immunosensor for the Optical Detection of Escherichia coli at Low Concentration Levels". IEEE Sensors Journal (2024): 1-1. http://dx.doi.org/10.1109/jsen.2024.3354057. Accepted • 10.1109/jsen.2024.3354057 Despoina Varamogianni-Mamatsi; Maria João Nunes; Vanda Marques; Thekla I. Anastasiou; Eirini Kagiampaki; Emmanouela Vernadou; Thanos Dailianis; et al. "Comparative Chemical Profiling and Antimicrobial/Anticancer Evaluation of Extracts from Farmed versus Wild Agelas oroides and Sarcotragus foetidus Sponges". Marine Drugs (2023): https://www.mdpi.com/1660-3397/21/12/612. 10.3390/md21120612 Marta Catalão; Mafalda Fernandes; Lorena Galdon; Clara F. Rodrigues; Rita G. Sobral; Susana P. Gaudêncio; Cristiana A. V. Torres. "Exopolysaccharide Production from Marine-Derived Brevundimonas huaxiensis Obtained from Estremadura Spur Pockmarks Sediments Revealing Potential for Circular Economy". Marine Drugs (2023): https://doi.org/10.3390/md21070419. 10.3390/md21070419 Sara Valente; Filipe Oliveira; Inês João Ferreira; Alexandre Paiva; Rita G. Sobral; Mário S. Diniz; Susana P. Gaudêncio; Ana Rita Cruz Duarte. "Hydrophobic DES Based on Menthol and Natural Organic Acids for Use in Antifouling Marine Coatings". ACS Sustainable Chemistry & Engineering (2023): https://doi.org/10.1021/acssuschemeng.3c01120. 10.1021/acssuschemeng.3c01120 Juliana Oliveira; Pedro L. Almeida; Rita G. Sobral; Nídia D. Lourenço; Susana P. Gaudêncio. "Marine-Derived Actinomycetes: Biodegradation of Plastics and Formation of PHA Bioplastics¿A Circular Bioeconomy Approach". Marine Drugs (2022): https://doi.org/10.3390/md20120760. 10.3390/md20120760 Selvi C. Ersoy; Barbara Gonçalves; Gonçalo Cavaco; Adhar C. Manna; Rita G. Sobral; Cynthia C. Nast; Richard A. Proctor; et al. "Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and ß-Lactam Sensitization in NaHCO 3 -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.03422-22. 10.1128/spectrum.03422-22 Raquel Portela; Nuno A. Faria; Michael Mwangi; Maria Miragaia; Hermínia de Lencastre; Alexander Tomasz; Rita Gonçalves Sobral; Joanna B. Goldberg. "Analysis of a Cell Wall Mutant Highlights Rho-Dependent Genome Amplification Events in Staphylococcus aureus". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.02483-21. 10.1128/spectrum.02483-21 Inês Silvestre; Vítor Borges; Sílvia Duarte; Nunes, Alexandra; Rita Sobral; Luís Vieira; João Paulo Gomes; Maria José Borrego. "Global gene expression analysis of Streptococcus agalactiae at the exponential growth phase". Cellular and Molecular Biology 68 7 (2022): 1-8. http://dx.doi.org/10.14715/cmb/2022.68.7.1. 10.14715/cmb/2022.68.7.1 Almeida, A.P.C.; Saraiva, J.N.; Cavaco, G.; Portela, R.P.; Leal, C.R.; Sobral, R.G.; Almeida, P.L.. "Crosslinked bacterial cellulose hydrogels for biomedical applications". European Polymer Journal 177 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134886920&partnerID=MN8TOARS. 10.1016/j.eurpolymj.2022.111438 António Pinto Almeida; Anelize Bauermeister; Luca Luppino; Inês R. Grilo; Juliana Oliveira; Joana R. Sousa; Daniel Petras; et al. "The Diversity, Metabolomics Profiling, and the Pharmacological Potential of Actinomycetes Isolated from the Estremadura Spur Pockmarks (Portugal)". Marine Drugs (2021): https://www.mdpi.com/1660-3397/20/1/21. 10.3390/md20010021 Florbela Pereira; Joana R. Almeida; Marisa Paulino; Inês R. Grilo; Helena Macedo; Isabel Cunha; Rita G. Sobral; Vitor Vasconcelos; Susana P. Gaudêncio. "Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus". Marine Drugs 18 1 (2020): 63-63. https://doi.org/10.3390/md18010063. 10.3390/md18010063 Pereira, F.; Figueiredo, T.; de Almeida, R.F.M.; Antunes, C.A.C.; Garcia, C.; Reis, C.P.; Ascensão, L.; Sobral, R.G.; Rijo, P.. "Unveiling the mechanism of action of 7a-acetoxy-6ß-hydroxyroyleanone on an mrsa/visa strain: Membrane and cell wall interactions". Biomolecules 10 7 (2020): 1-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-85087344220&partnerID=MN8TOARS. 10.3390/biom10070983 Portela, R.; Valcovo, F.; Almeida, P.L.; Sobral, R.G.; Leal, C.R.. "Antibiotic Activity Screened by the Rheology of S. aureus Cultures". Fluids 5 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085998230&partnerID=MN8TOARS. 10.3390/fluids5020076 Bárbara V. Gonçalves; Raquel Portela; Ricardo Lobo; Teresa A. Figueiredo; Inês R. Grilo; Ana Madalena Ludovice; Hermínia de Lencastre; Jorge S. Dias; Rita G. Sobral. "Role of MurT C-Terminal Domain in the Amidation of Staphylococcus aureus Peptidoglycan". Antimicrobial Agents and Chemotherapy (2019): https://doi.org/10.1128/AAC.00957-19. 10.1128/AAC.00957-19 Portela, Raquel; Leal, Catarina R.; Almeida, Pedro L.; Sobral, Rita G.. "Bacterial cellulose: a versatile biopolymer for wound dressing applications". Microbial Biotechnology 12 4 (2019): 586-610. http://dx.doi.org/10.1111/1751-7915.13392. 10.1111/1751-7915.13392 Maugeri, G.; Lychko, I.; Sobral, R.; Roque, A.C.A.. "Identification and Antibiotic-Susceptibility Profiling of Infectious Bacterial Agents: A Review of Current and Future Trends". Biotechnology Journal 14 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85052470675&partnerID=MN8TOARS. 10.1002/biot.201700750 Reichmann, N.T.; Tavares, A.C.; Saraiva, B.M.; Jousselin, A.; Reed, P.; Pereira, A.R.; Monteiro, J.M.; et al. "SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus". Nature Microbiology 4 8 (2019): 1368-1377. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065766105&partnerID=MN8TOARS. 10.1038/s41564-019-0437-2 Sobral, R.; Tomasz, A.. "The staphylococcal cell wall". Microbiology Spectrum 7 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070089993&partnerID=MN8TOARS. 10.1128/microbiolspec.GPP3-0068-2019 Espadinha, D.; Sobral, R.G.; Mendes, C.I.; Méric, G.; Sheppard, S.K.; Carriço, J.A.; Lencastre, H.; Miragaia, M.. "Distinct phenotypic and genomic signatures underlie contrasting pathogenic potential of staphylococcus epidermidis clonal lineages". Frontiers in Microbiology 10 AUG (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071949780&partnerID=MN8TOARS. 10.3389/fmicb.2019.01971 Portela, R.; Almeida, P.L.; Sobral, R.G.; Leal, C.R.. "Motility and cell shape roles in the rheology of growing bacteria cultures". European Physical Journal E 42 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85062224223&partnerID=MN8TOARS. 10.1140/epje/i2019-11787-9 Bauermeister, A.; Pereira, F.; Grilo, I.R.; Godinho, C.C.; Paulino, M.; Almeida, V.; Gobbo-Neto, L.; et al. "Intra-clade metabolomic profiling of MAR4 Streptomyces from the Macaronesia Atlantic region reveals a source of anti-biofilm metabolites". Environmental Microbiology 21 3 (2019): 1099-1112. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062889469&partnerID=MN8TOARS. 10.1111/1462-2920.14529 Harrison, E.M.; Ba, X.; Coll, F.; Blane, B.; Restif, O.; Carvell, H.; Köser, C.U.; et al. "Genomic identification of cryptic susceptibility to penicillins and ß-lactamase inhibitors in methicillin-resistant Staphylococcus aureus". Nature Microbiology 4 10 (2019): 1680-1691. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068179394&partnerID=MN8TOARS. 10.1038/s41564-019-0471-0 Leisico, Francisco; V. Vieira, Diana; Figueiredo, Teresa A.; Silva, Micael; Cabrita, Eurico J.; Sobral, Rita G.; Ludovice, Ana Madalena; et al. "First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-22986-3. 10.1038/s41598-018-22986-3 Joana Rita Gonçalves Araujo Rolo Mateus; Peder Worning; Jesper Boye Nielsen; Rita Sobral; Rory Bowden; Ons Bouchami; Peter Damborg; et al. "Evidence for the evolutionary steps leading to mecA-mediated ß-lactam resistance in staphylococci". PLoS Genetics 13 4 (2017): https://research.unl.pt/en/publications/evidence-for-the-evolutionary-steps-leading-to-mecamediated-lactam-resistance-in-staphylococci(ea431b4e-6ee9-4dd2-b0d2-b1055845d990).html. 10.1371/journal.pgen.1006674 Portela, R.; Patrício, P.; Almeida, P. L.; Sobral, R. G.; Franco, J. M.; Leal, C. R.. "Rotational tumbling of Escherichia coli aggregates under shear". Physical Review E 94 6 (2016): http://dx.doi.org/10.1103/physreve.94.062402. 10.1103/physreve.94.062402 R Portela; Pedro Patrício; P L Almeida; Rita Sobral; J. M. Franco; C R Leal. "Rotational tumbling of Escherichia coli aggregates under shear". Physical Review E 94 6 (2016): https://research.unl.pt/en/publications/rotational-tumbling-of-escherichia-coli-aggregates-under-shear(be1c1751-1c35-48da-a833-e20ffbfc6877).html. 10.1103/PhysRevE.94.062402 Filipa Siopa; Teresa Figueiredo; Raquel F. M. Frade; Iris Neto; Ana Meirinhos; Catarina P. Reis; Rita Sobral; Carlos A. M. Afonso; Patrícia Rijo. "Choline-Based Ionic Liquids". ChemistrySelect 1 18 (2016): 5909-5916. https://research.unl.pt/en/publications/cholinebased-ionic-liquids(808e811b-42da-46ed-a139-47d20399497e).html. 10.1002/slct.201600864 Patrício, P.; Almeida, P.L.; Portela, R.; Sobral, R.G.; Grilo, I.R.; Cidade, T.; Leal, C.R.. "Living bacteria rheology: Population growth, aggregation patterns, and collective behavior under different shear flows". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 90 2 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940331458&partnerID=MN8TOARS. 10.1103/PhysRevE.90.022720 Vieira, D.; Figueiredo, T.A.; Verma, A.; Sobral, R.G.; Ludovice, A.M.; De Lencastre, H.; Trincao, J.. "Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase-like protein from Staphylococcus aureus peptidoglycan". Acta Crystallographica Section F:Structural Biology Communications 70 5 (2014): 632-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905435586&partnerID=MN8TOARS. 10.1107/S2053230X14007298 Figueiredo, T.A.; Ludovice, A.M.; Sobral, R.G.. "Contribution of peptidoglycan amidation to beta-lactam and lysozyme resistance in different genetic lineages of staphylococcus aureus". Microbial Drug Resistance 20 3 (2014): 238-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902201410&partnerID=MN8TOARS. 10.1089/mdr.2014.0042 Grilo, I.R.; Ludovice, A.M.; Tomasz, A.; de Lencastre, H.; Sobral, R.G.. "The glucosaminidase domain of Atl - the major Staphylococcus aureus autolysin - has DNA-binding activity". MicrobiologyOpen 3 2 (2014): 247-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897977745&partnerID=MN8TOARS. 10.1002/mbo3.165 Atilano, M.L.; Pereira, P.M.; Vaz, F.; Catalão, M.J.; Reed, P.; Grilo, I.R.; Sobral, R.G.; et al. "Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the drosophila innate immune system". eLife 2014 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84898467936&partnerID=MN8TOARS. 10.7554/eLife.02277 Portela, R.; Almeida, P.L.; Patrício, P.; Cidade, T.; Sobral, R.G.; Leal, C.R.. "Real-time rheology of actively growing bacteria". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 87 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875496516&partnerID=MN8TOARS. 10.1103/PhysRevE.87.030701 Figueiredo, T.A.; Sobral, R.G.; Ludovice, A.M.; de Almeida, J.M.F.; Bui, N.K.; Vollmer, W.; de Lencastre, H.; Tomasz, A.. "Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus". PLoS Pathogens 8 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857491427&partnerID=MN8TOARS. 10.1371/journal.ppat.1002508 Sobral, R.G.; Jones, A.E.; Des Etages, S.G.; Dougherty, T.J.; Peitzsch, R.M.; Gaasterland, T.; Ludovice, A.M.; De Lencastre, H.; Tomasz, A.. "Extensive and genome-wide changes in the transcription profile of Staphylococcus aureus induced by modulating the transcription of the cell wall synthesis gene murF". Journal of Bacteriology 189 6 (2007): 2376-2391. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947175462&partnerID=MN8TOARS. 10.1128/JB.01439-06 Sobral, R.G.; Ludovice, A.M.; De Lencastre, H.; Tomasz, A.. "Role of murF in cell wall biosynthesis: Isolation and characterization of a murF conditional mutant of Staphylococcus aureus". Journal of Bacteriology 188 7 (2006): 2543-2553. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645243418&partnerID=MN8TOARS. 10.1128/JB.188.7.2543-2553.2006 Gardete, S.; Ludovice, A.M.; Sobral, R.G.; Filipe, S.R.; De Lencastre, H.; Tomasz, A.. "Role of murE in the Expression of ß-Lactam Antibiotic Resistance in Staphylococcus aureus". Journal of Bacteriology 186 6 (2004): 1705-1713. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542317110&partnerID=MN8TOARS. 10.1128/JB.186.6.1705-1713.2004 Sobral, R.G.; Ludovice, A.M.; Gardete, S.; Tabei, K.; De Lencastre, H.; Tomasz, A.. "Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus". Microbial Drug Resistance 9 3 (2003): 231-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041353701&partnerID=MN8TOARS. 10.1089/107662903322286436 De Lencastre, H.; Wu, S.W.; Pinho, M.G.; Ludovice, A.M.; Filipe, S.; Gardete, S.; Sobral, R.; et al. "Antibiotic resistance as a stress response: Complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin". Microbial Drug Resistance 5 3 (1999): 163-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032755508&partnerID=MN8TOARS.

Intellectual property

Patent	S.P. Gaudencio; Rita G. Sobral; F. Pereira; I. Santos-Sanches; S. Gonçalves; V. Vasconcelos; I. Cunha; J. Almeida. 2018. "Use of napiradiomycins with antifouling activity and thereof compositions". Granted/Issued
Provisional application for patent	2020. "Protein for detecting the presence of peptidoglycan, muropeptides or bacterial cells, sensor and uses thereof". Protected

Other

Other output

Global gene expression analysis of Streptococcus agalactiae at exponential growth phase. 2020. Silvestre, I.; Borges, V.; Duarte, S.; Nunes, A.; Sobral, R.; Vieira, L.; Gomes, J.P.; Borrego, M.J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098862062&partnerID=MN8TOARS.
10.1101/2020.11.13.381939
Molecular Networking to target the isolation of novel isoprenoids derivatives from marine-derived actinomycetes. 2019. Anelize Bauermeister; Florbela Pereira; Inês R. Grilo; Alejandra Prieto-davó; Rita Sobral; Norberto Lopes; Susana P. Gaudencio. https://novaresearch.unl.pt/en/publications/8a66f788-e8a9-44ce-8606-b215f86daaf6.
10.3389/conf.FMARS.2018.06.00160

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/05/31	Liquid Crystal-based polarization immunosensor for Escherichia coli detection	Optical sensors 2023 (SPIE) (prague, Czech Republic)
2022/11/10	Liquid Crystal based bacterial infection biossensor	7th International Colloquium 'Physics of Materials' (Bucareste, Romania)
2022/04/26	Rheology of Bacterial Cellulose wound dressing membranes	Annual European Rheology Conference 2022 (AERC2022) (Spain)
2022/04/23	Impact of peptidoglycan amidation on cell surface properties and biofilm formation in Staphylococcus aureus	32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) (lisbon, Portugal)
2021/11/23	Marine-derived actinobacteria produce bioplastics while degrading (micro)plastics?	Congress of Microbiology and Biotechnology 2021 (MicroBiotec’21) (Portugal)
2020/07/20	Temperature influence in the rheology of living S. aureus cultures	11th Liquid Matter Conference (Liquids 2020) (Praga)
2019/11/01	Tackling bacterial resistance using antibiotics as ionic liquids and organic salts	5 th International Electronic Conference of Medicinal Chemistry
2019/04/13	Strategies of adaptation of Staphylococcus epidermidis lineages to commensal and pathogenic lifestyle	29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (amesterdão, Netherlands)
2019	S. aureus and E. coli co-culture growth under shear.	7th Iberian Meeting on Rheology 2019 - IbeReo2019. (Porto, Portugal)
2019	Ionic Liquids Derived from ß-Lactam Antibiotics Against Resistant Bacteria.	3rd International Caparica Conference in Antibiotic Resistance (Caparica, Portugal)
2019	Impact of peptidoglycan amidation on the autolysis of Staphylococcus aureus.	IV NOVAhealth Genetics Workshop (Lisboa, Portugal)
2019	Modifying the cell wall of Staphylococcus aureus – role in antibiotic resistance and interactions with the environment.	Mini-symposium - Biological insights into pathogenicity in staphylococci. (Oeiras, Portugal)
2018/07/05	Molecular Networking to target the isolation of novel isoprenoids derivatives from marine-derived actinomycetes.	International Meeting on Marine Research. 10.3389/conf.FMARS.2018.06.00160 (Peniche, Portugal)
2018/04/21	Adaptation of Staphylococcus epidermidis from commensalism towards pathogenicity.	28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (Madrid, Spain)
2018/04/17	Shear flow complex motion in Escherichia coli aggregates.	Annual European Rheology Conference. (Sorrento, Italy)
2018/03/09	The staphylococcal surface – an interaction platform with the host	IV Semana da Bioengenharia. Symposium - The War Against Infections. Instituto Superior Técnico, Universidade de Lisboa. (Lisboa, Portugal)
2017/12/07	Genomic adaptation strategies of Staphylococcus epidermidis from commensal to pathogen	MICROBIOTEC17 –Congress of Microbiology and Biotechnology (Porto, Portugal)
2017/12/04	Blue Biotechnological potential of antimicrobial natural products from marine-derived actinomycetes	2nd International Caparica Christmas Congress on Translational Chemistry (IC3TC 2017) (Caparica, Portugal)
2017/10/02	The cell wall of Staphylococcus aureus - implications in antibiotic resistance and interaction with the host	3º Workshop de Genética – NOVASAÚDE (Portugal)
2017/09/06	Rotational and translational motion observed in Escherichia coli aggregates during shear.	Iberian Meeting on Rheology 2017, IbeReo2017 (Valencia, Spain)
2017/09/03	Hybrid-isoprenoids from MAR4 strains isolated from Madeira Archipelago as a source of antimicrobial compounds with biotechnological potential.	10thEuropean Conference of Marine Natural Products. (Creta, Greece)
2017/07/26	Staphylococcus aureus: antibiotic resistance and interaction with the host	Biomolecular Engineering Symposium (Portugal)
2017/07/16	Ocean Treasures: Marine actinomycetes as a source of antimicrobial compounds with industrial applications	XXV Encontro Nacional da Sociedade Portuguesa de Química (Lisboa, Portugal)
2017/06/11	GL-DNA interaction affects the peptidoglycan hydrolytic activity of GL.	19thConference on Bacilli & Gram-positive Bacteria (Berlim, Germany)
2016/08/08	Living S. aureus bacteria rheology	The XVIIth International Congress on Rheology (ICR2016) (Kyoto, Japan)
2016/06/02	Essential core residues of MurT/GatD complex for peptidoglycan amidation in Staphylococcus aureus.	XL Portuguese Genetics Conference (Coimbra, Portugal)
2016/05/30	Staphylococcus aureus - transcriptomic analysis of a cell wall impaired mutant	2nd Genetics Workshop (Lisboa, Portugal)
2016/03/09	Exploring the key factors for the success of clonal complex 2 (cc2), the main Staphylococcus epidermidis lineage	IMMEM XI (ESCMID-ESGEM conference), International Meeting on Microbial Epidemiological Markers. (Lisboa, Portugal)
2016/03/09	Evolution of the skin commensal Staphylococcus epidermidis in hospital environment: insights from an early collection.	IMMEM XI (ESCMID-ESGEM conference), International Meeting on Microbial Epidemiological Markers (Lisboa, Portugal)
2015/09/07	Cell necklaces behave as a soft glassy material.	Iberian Meeting on Rheology (IbeReo2015) (Coimbra, Portugal)
2015/06/10	The importance of GL-eDNA binding for biofilm formation in Staphylococcus aureus	59th Wind River Conference on Prokaryotic Biology (Aspen, United States)
2015/05/25	Time series analysis of the transcriptome of a S. with an impaired cell wall	XXXIX Jornadas Portuguesas de Genética (Braga, Portugal)
2015/05/25	Establishment of MurT/GatD complex as a new virulence factor – role in host evasion	XXXIX Jornadas Portuguesas de Genética
2014/12	DNA binding at the surface of Staphylococcus aureus - the role of Atl	Mini-Symposium - Two bacterial pathogens and a way to kill them ITQB, UNL (Portugal)
2014/06	How to tackle a tiny but powerful enemy? Fundamental approaches to bacterial physiology	Science conferences at noon ITQB, UNL (Portugal)
2013/10	How can rheology help study growth and death of bacteria	9th Ibero-American Workshop on Complex Fluids (Brazil)
2013/09	Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the host	3rd Symposium – The dynamics of peptidoglycan structure and function. (France)
2013/09	Real-time rheology of actively growing Staphylococcus aureus.	International Soft Matter Conference. (Roma, Italy)
2013/09	Staphylococcus aureus strains rheology during growth	Ibereo2013 Fundamental and Applied Rheology (Malaga, Spain)
2012/08	Rheological characterization of bacterial growth in the presence of antibiotics	The XVIth International Congress on Rheology (Lisboa, Portugal)
2011/12	Genome comparison of a Staphylococcus aureus mutant showing decreased antibiotic resistance and its revertant strain	MICROBIOTEC’11 (Braga, Portugal)
2011/03	Peptidoglycan structure and antibiotic resistance in Staphylococcus aureus	CREM, Centro de Recursos Microbiológicos, FCT, UNL (Caparica, Portugal)
2011	Bacterial growth screened by rheology	IbeReo 2011-Rheology trends: from nano to macro systems (Caparica, Portugal)
2010/02	Resistance to antibiotics – molecular mechanisms	Escola Superior de Tecnologia, Instituto Politécnico de Setúbal (Setúbal, Portugal)
2009/11	A new enzyme involved in the N-acetylation of muramic acid residues of peptidoglycan in Staphylococcus aureus: Impact on growth, oxacillin resistance and lysozyme sensitivity	Microbiotec09 (Vilamoura, Portugal)
2009	Global expression analysis of a Staphylococcus aureus mutant with an impaired cell wall	Microbiotec09 (Vilamoura, Portugal)
2008/10	A new player in the peptidoglycan biosynthesis of Staphylococcus aureus	Pathophysiology of Staphylococci (Bad Staffelstein, Germany)
2007/06	Microarray approach to the study of a murF insertion mutant	4th Conference on Functional Genomics of Gram-Positive Microorganisms (Tirrenia, Italy)
2003/09	Cell wall biosynthesis and b-lactam resistance in Staphylococcus aureus - the contribution of auxiliary gene murF	43rd Interscience Congress on Antimicrobial Agents and Chemotherapy (ICAAC) (Chicago, United States)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09/03 - Current	Exploring the role of a new two-peptide system of Staphylococcus aureus in the interaction with other bacteria and the host Supervisor of Ana Rita Sequeira	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/03 - Current	Characterization of the human proteome and the influence of the Mediterranean diet Co-supervisor of Eduardo Costa-Camilo	Microbiologia (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/09/03 - Current	Targeted actinomycete isolation from the River Tagus Bay and Sesimbra sediments, taxonomic characterization, and evaluation of antimicrobial potential Co-supervisor of Miguel Coelho	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/03 - Current	Targeted actinomycete isolation from the Azores Archipelago sediments, taxonomic characterization, and evaluation of antimicrobial potential Co-supervisor of Tiago Correia	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/10/01 - Current	Deciphering the role of mycobacterial peptidoglycan modifications in host immune recognition and antibiotic resistance of Mycobacterium tuberculosis Co-supervisor of Cátia Raquel Lopes Silveiro	Programa doutoral em Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/03/01 - Current	Biochemical and functional characterization of enzymes from Neisseria gonorrhoeae and Staphylococcus aureus important for the infection process Co-supervisor of Daniela Sofia Colaço Barreiro	Bioquímica (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Current	The role of peptidoglycan amidation in the structure of Staphylococci population – impact on biofilm formation Supervisor of Gonçalo Cavaco	Biologia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/02 - 2023/12/18	Characterization of an ABC-Type I importer in Staphylococcus aureus Co-supervisor of Ana Catarina Pinguelo Martins dos Santos	Microbiologia Médica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/02 - 2023/11/22	Targeted Actinomycete Isolation from Macaronesia, Taxonomic Characterization and Evaluation of Antimicrobial potential Co-supervisor of Daniela Parreira	Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/02 - 2023/11/09	Search for bioactive compounds with antioxidant and antibacterial activity in seaweed species from the Portuguese coast Co-supervisor	Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2022/12/20	A new target inside an old molecule: glutamate amidation of peptidoglycan Supervisor of Barbara Gonçalves	Biologia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/09/01 - 2022/12/06	Structural characterization of the c-terminal domain of endolysin plymw2 and interaction with the peptidoglycan of Staphylococcus aureus Co-supervisor of Marlene Pimentel Leite	Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/10/01 - 2022/05/24	Bacterial Cellulose for Biomedical Applications Co-supervisor of João Saraiva	Ciências de Engenharia Biomédica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/10/01 - 2022/02/25	Targeted actinomycete isolation from the Estremadura Spur, taxonomic characterization and evaluation of antimicrobial potential Co-supervisor of Anilton Ianga	Química Bioorgânica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/02/25	Novel alkylaminophenols as antibacterial agents against Staphylococcus aureus infections Co-supervisor of Bárbara André Alves	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/01/19	Insights into the copper tolerance in Staphylococcus aureus Co-supervisor of Alicia Tostão	Microbiologia Médica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/09 - 2022/01/17	Influence of peptidoglycan amidation on lysozyme resistance of Staphylococcus aureus Supervisor of Ana Catarina Laço Fanico	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/01/17	Caracterization of the role of the scwdABC system of Staphylococcus aureus in inter-species and host interactions Supervisor of Miguel Patinho Silva	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/01/14	Development and optimization of a bacterial infection biosensor using recombinant staphylococcal proteins Supervisor of Pedro Miguel Reis Ganhão	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/09/01 - 2022/01/12	Evaluation of Quaternary Ammonium Surfactants as prophylactic options for Streptococcus agalactiae infections Co-supervisor of Carolina Borges Ferreira	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/07/01 - 2021/08/31	Development of a bacterial infection sensor based on S. aureus recombinant proteins Supervisor of Inês Ramos Grilo	Pós-doutoramento (Other) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2021/07/01 - 2021/07/31	Biotechnological studies of jellyfish and actinomycetes collected off Tagus River - Short Term Scientific Mission (STSM). COST Action Ocean4Biotech (CA18238). Supervisor of Jan Ulcar	COST Action Ocean4Biotech (CA18238) (Specialization course) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015 - 2021/03/02	Contribution of genomics and transcriptomics to the understanding of the biological role of DNases in Streptococcus agalactiae Co-supervisor of Inês Silvestre	Biologia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2021/01/15	Influence of a nisin-biogel on virulence factors expression by Staphylococcus aureus isolates from Diabetic Foot Infections Co-supervisor of Carolina de Oliveira Jesus	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/10 - 2020/11/09	Biodiversity of marine bacteria in ocean sediments from the pockmarks of the Estremadura Spur Co-supervisor of António Pinto Almeida	Bolsa Pós-doutoramento António Coutinho (Specialization course) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2020/09/01 - 2020/10/31	Biotechnological study of the chemical diversity of dinoflagellates Supervisor of Nathalia Peixoto Nocchi Carneiro	Short Term Scientific Mission (STSM). COST Action Ocean4Biotech (CA18238) (Specialization course) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014 - 2019/12	New studies in the resistance to beta-lactams and in cell wall damage survival in Staphylococcus aureus: an integrated approach Supervisor of Raquel Portela	Biologia (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019/07	Functionalization of recombinant proteins for matrix conjugation in a bifunctional infection sensor Supervisor of José Diogo Anastácio	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2019	Identification of key factors for the success of the main Staphylococcus epidermidis genetic lineage Co-supervisor of Diana Espadinha	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017 - 2018/11	Activity of the major autolysin of Staphylococcus aureus Atl in the presence of extracellular DNA Supervisor of Catarina Madeira	Bioquímica para a Saúde (Master) Universidade Nova de Lisboa, Portugal
2017 - 2018	Peptidoglycan amidation of Staphylococcus aureus and bacterial cell physiology Co-supervisor of Gonçalo Cavaco	Microbiologia Médica (Master) Universidade Nova de Lisboa, Portugal
2015 - 2016	Anti-biofilm activity of natural products from marine actinobacteria for the development of antifouling dyes Co-supervisor of Helena Macedo	Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2016	Origin and evolution of the ß–lactam resistance determinant in staphylococci Co-supervisor of Joana Rolo Mateus	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011 - 2016	Unfolding the physiological roles of the binding of Atl to eDNA in S. aureus Co-supervisor of Inês R. Grilo	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2015	Characterization of the major autolysin of S. aureus Supervisor of Joana Silva	Microbiologia Médica (Master) Universidade Nova de Lisboa, Portugal
2014 - 2015	Gold nanoprobes for assessing expression of critical genes in the infection pathway of MRSA Supervisor of Andreia Fortuna	Biotecnologia (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014	A new antimicrobial target in Staphylococcus aureus – amidation of peptidoglycan Supervisor of Barbara Gonçalves	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014	Role of DUF1727 domain in the amidation of peptidoglycan of Staphylococcus aureus Supervisor of Ricardo Lobo	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2014	Amidation of Peptidoglycan in Staphylococcus aureus - Identification of MurT-GatD enzymatic complex and insights into the biological role of this secondary modification Co-supervisor of Teresa A. Figueiredo	Biologia (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2009	Regulatory characterization of S. aureus dcw islands Co-supervisor of Inês R. Grilo	Genética Molecular e Biomedicina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2021/01/21 - 2021/01/25	Workshop "Scientific writing" (remoto) (2021/01/21 - 2021/01/25) Workshop (President of the Organising Committee)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023 - 2023	European Researchers´night Exhibition	Unidade de Ciências Biomoleculares Aplicadas, Portugal
2021/09/24 - 2021/09/24	European Researchers night Exhibition	European Researchers night Unidade de Ciências Biomoleculares Aplicadas, Portugal
2018 - 2018	European researchers night Exhibition	European Researchers night Unidade de Ciências Biomoleculares Aplicadas, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022/11/22	Ecological Interactions in Pseudomonas aeruginosa – Staphylococcus aureus mixed biofilms: deciphering co-infection in cystic fibrosis airways (Thesis) Main arguer	Andreia Patrícia Alves Magalhães (PhD) Universidade do Minho, Portugal
2022/02/04	Detection and characterization of rickettsias and other zoonotic agents in wild animals e their ectoparasites President of the jury	Inês Campos Freitas (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/02	Identification of new drugs against Neisseria gonorrhoeae through a strategy of repositioning in silico President of the jury	André Pinho de Pina (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/25	Virulence potencial of Staphylococcus aureus from skin and soft tissue infections President of the jury	Ketlyn Flora de Oliveira (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/25	Anatomy of the disease-related Dis3L2 ribonuclease: dissecting the amino acids responsible for substrate specificity President of the jury	Susana Margarida Marques Costa (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/24	Human polyomaviruses in waste and environmental waters in the Lisbon Metropolitan Area President of the jury	Ana Carolina de Oliveira Condez (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/24	Zap1 is required for Candida glabrata response to fluconazole President of the jury	Gonçalo dos Santos Afonso (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/11	Carbapenem Resistance in Clostridioides difficile (Thesis) Main arguer	Aristides Mendes (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/02/08	Significance of mycobacterial peptidoglycan amidation in host immune recognition and antibiotic resistance (Thesis) Main arguer	Mariana Ferreira Balula Marques (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/26	Characterization of protein-protein interactions in the Bacillus subtilis AraNPQ-MsmX transporter (Thesis) Main arguer	Joana Raquel Encarnação Almeida (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/01/13	Screening for carbapanemases at the emergency service of clinical pathology of the São José hospital (Thesis) Main arguer	Vera Lúcia Martins Fevereiro Ruivo de Sousa (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/12	Phenotypic and genotypic characterization of Salmonella spp. isolates in Portugal (Thesis) Arguer	Leonor Silveira (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/12	New studies in the resistance to beta-lactams and in cell wall damage survival in Staphylococcus aureus: an integrated approach Supervisor	Raquel Pereira Portela (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/06	Functionalization of recombinant proteins for matrix conjugation in a bifunctional infection sensor Supervisor	José Diogo Anastácio (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/11	Molecular biology in the context of the emergency service of clinical pathology of the CHLC-Hospital de S. José (Thesis) Main arguer	Sónia Marujo (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/11	Activity of the major autolysin of Staphylococcus aureus Atl in the presence of extracellular DNA Supervisor	Catarina Madeira (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/12	The role of a new S. aureus hydrolase in Peptidoglycan degradation (Thesis) Main arguer	Jéssica Gomes (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/11	Development of a laboratorial procedure of Next Generation Sequencing for DNA unviable for Sanger sequencing (Thesis) Main arguer	Oleksandra Zabolotnya (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/06	Abietane Cationic Amphiphiles (ACA)-loaded polymeric microspheres to tackle resistant bacteria (Thesis) Main arguer	Íris Branco Neto (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/04	Unfolding the physiological roles of the binding of Atl to eDNA in S. aureus Supervisor	Maria Inês Ramos Grilo (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/04	A minimal version of a Protein Tyrosine Phosphatase (Thesis) Main arguer	Luis Silva (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/01	Characterization of the major autolysin of S. aureus Supervisor	Joana Silva (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/11	Gold nanoprobes for assessing expression of critical genes in the infection pathway of MRSA Supervisor	Andreia Fortuna (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/12	Amidation of Peptidoglycan in Staphylococcus aureus - Identification of MurT-GatD enzymatic complex and insights into the biological role of this secondary modification Supervisor	Teresa Figueiredo (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/12	A new antimicrobial target in Staphylococcus aureus – amidation of peptidoglycan Supervisor	Barbara Vitorino Gonçalves (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/11	Role of DUF1727 domain in the amidation of peptidoglycan of Staphylococcus aureus Supervisor	Ricardo Lobo (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/12	Study of the Role of Wall Teichoic Acids in the Localization of Staphylococcus aureus Cell Wall Synthesis protein PBP4 (Thesis) Main arguer	Gabriela Henriques (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/03	Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase (Thesis) Main arguer	Tiago Botelho (PhD) Instituto de Biología Molecular de Barcelona, Spain
2009/12	Regulatory characterization of S. aureus dcw islands Supervisor	Maria Inês Ramos Grilo (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Committee member

	Activity description Role	Institution / Organization
2023/05/01 - Current	Member of the Executive Committee of the Applied Molecular Biosciences Unit (UCIBIO) Member	Unidade de Ciências Biomoleculares Aplicadas, Portugal
2021/01/01 - Current	Membro da Comissão Científica do Mestrado em Microbiologia Médica (Universidade Nova de Lisboa - FCT, FCM, IHMT, ITQB) Member	Universidade Nova de Lisboa, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2021/10 - Current	Molecular and Celular Biology	Licenciatura em Engenharia Química e Bioquímica (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/07/01 - Current	Biofilms in chronic diseases	Microbiologia Médica (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/09 - Current	Applied Microbiology	Genética Molecular e Biomedicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/09 - Current	Applied Microbiology	Biologia Celular e Molecular (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/03 - Current	Laboratory methodologies in Biology II	Biologia Celular e Molecular (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/03 - Current	Microbiology B	Biologia Celular e Molecular (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/03 - Current	Microbiology C	Engenharia do Ambiente (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/01 - Current	Laboratory rotations	Genética Molecular e Biomedicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/09 - 2015/01	Regulation of genetic expression	Genética Molecular e Biomedicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/02 - 2013/04	Introduction to scientific research program	Biologia Celular e Molecular (Licenciatura)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/01 - 2010/09	Biochemistry	Engenharia Química (Licenciatura)	Instituto Politécnico de Setúbal Escola Superior de Tecnologia do Barreiro, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2022/01 - Current	Member of evaluation body of SNSF Swiss Postdoctoral Fellowships Evaluator
2016 - Current	Evaluator of grant applications for the Swiss National Foundation. Evaluator

Journal scientific committee

	Journal title (ISSN)	Publisher
2022 - Current	Microbiology spectrum
2021 - Current	Proceedings of the National Academy of Sciences
2021 - Current	Journal of Antimicrobial Chemotherapy
2019 - Current	PLoS Pathogens (1553-7374)	Public Library of Science
2019 - Current	MicrobiologyOpen (2045-8827)	Wiley (John Wiley & Sons)
2019 - Current	Nature Chemical Biology (1552-4469)	Springer Science and Business Media LLC
2013 - Current	PLoS ONE (1932-6203)	Public Library of Science
2010 - Current	Microbial Drug Resistance (1931-8448)	Mary Ann Liebert

Distinctions

Award

2015	Research Grant Award 2015 European Society of Clinical Microbiology and Infectious Diseases, Switzerland
2011	Research Grant award 2011 European Society of Clinical Microbiology and Infectious Diseases, Switzerland