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Ângelo Ferreira Chora (AFC) has a BSc in Microbiology and Genetics and a PhD. in Biomedical Sciences, both granted by Lisbon University. He has developed his research in both national and international host institutions. Of notice, he had a two-year training period in Harvard Medical School, Boston, USA, after which he initiated his graduate studies in the Instituto Gulbenkian de Ciência, Oeiras. After completion, AFC moved to Instituto de Medicina Molecular João Lobo Antunes, Lisbon, where he concluded in 2013 a successful post-doctoral period. In 2014, AFC integrated the Biology and Physiology of Malaria Unit led by Maria M. Mota. There, he developed his own lines of research, bringing an original perspective to the field of Host-Plasmodium interactions. AFC has a relevant record of original publications, with several high-impact articles and book chapters (3599 citations and h-index of 17; Google Scholar, August 2024). He has secured funding from competitive sources and demonstrated his ability to translate financial support into impactful research outputs. In 2024, AFC was awarded a Principal Investigator contract in the sixth edition of the Individual Call to Scientific Employment Stimulus (CEEC), a testament to his expertise and contributions. Overall, the discoveries encapsulated in his research significantly advance the comprehension of disease tolerance mechanisms with a particular focus on malaria, and provide crucial insights into potential therapeutic approaches and the formulation of strategies to combat infectious diseases.
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Identification

Personal identification

Full name
Ângelo António Ferreira Chaves do Rosário Chora

Citation names

  • Chora, Ângelo
  • Chora, Ângelo Ferreira

Author identifiers

Ciência ID
8112-E177-A53D
ORCID iD
0000-0002-7941-7196

Email addresses

  • angelochora@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • 214407900 (Professional)

Addresses

  • Instituto Medicina Molecular. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Sala P3-B-40, Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2011/04/01
Concluded
 Category B Researcher, Investigador de Categoria B (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2008
Concluded
 Biomedical Sciencies, Ciências Biomédicas (Doutoramento)
Major in Specialization field: Biopathological Sciencies; Especialidade: Ciências Biopatológicas
Universidade de Lisboa Faculdade de Medicina, Portugal
"Role of the Protective Gene Heme Oxygenase - 1 in the Control of T Cell Mediated Responses" (THESIS/DISSERTATION)
 Magna cum laude
1992/09/01 - 1997/11/01
Concluded
 Microbiology and Genetics, Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Characterization of a new molecular partner of E2A in Acute Lymphoblastic Leukemia" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2024/11/01 - Current Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2019/08/01 - 2024/07/31 Contracted Researcher (Research) Instituto de Medicina Molecular, Portugal
2014/02/01 - 2019/07/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2017/05/01 - 2017/08/31 Visiting Researcher (Research) The Peter Doherty Institute for Infection and Immunity, Australia
The Peter Doherty Institute for Infection and Immunity, Australia
2009/10/01 - 2013/07/01 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2002/09/01 - 2008/07/01 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
2000/03/01 - 2002/05/01 Researcher (Research) Harvard Medical School, United States
Massachusetts General Hospital, United States
1999/07/01 - 1999/09/01 Researcher (Research) University of Oxford, United Kingdom
University of Oxford Department of Biochemistry, United Kingdom
1997/10/01 - 1999/06/01 Research Assistant (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1996/10/01 - 1997/09/01 Research Trainee (Research) Università degli Studi di Milano - Dipartimento di Genetica e di Biologia dei Microorganismi, Italy
Università degli Studi di Milano - Dipartimento di Genetica e di Biologia dei Microorganismi, Italy

Teaching in Higher Education

Category
Host institution 		Employer
2024/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2015/10/01 - 2018/07/31 Molecular and cellular mechanisms of Plasmodium sensing during malarial liver-stage infection.
SFRH/BPD/112009/2015
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/01 Role of newly identified genes in in vivo antigen cross-presentation-dependent generation of CTL responses against tumors
SFRH/BPD/64906/2009
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000/02/01 - 2005/01/31 Regulation of T cell-mediated Immune Responses by the Stress Responsive Gene Heme Oxygenase-1
SFRH/BD/3106/2000
PhD Student Fellow
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1997/09/01 - 1999/06/30 Regulation of RNA degradation in Escherichia coli
PRAXIS XXI/BTI/14684/97
Research Technician Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/10/01 - 2022/09/30 Plasmodium cross-stage interplay modulates Severe Malaria pathology.
PTDC/MED-IMU/28664/2017
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/02/01 - 2013/12/31 Role of newly identified genes in in vivo antigen cross-presentation-dependent generation of CTL responses against tumors
PTDC/SAU-IMU/110303/2009
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Götz, Anton; Ty, Maureen; Chora, Angelo Ferreira; Zuzarte-Luís, Vanessa; Mota, Maria M.; Rodriguez, Ana. "Innate Immunity to Malaria". In Malaria: immune response to infection and vaccination, 3-25. Springer International Publishing, 2017.
    Published • 10.1007/978-3-319-45210-4_1
  2. Silva, Gabriela; Grégoire, Isabel Pombo; Tokaji, Lazlo; Chora, Ângelo Ferreira; Seldon, Mark Pena; Marinho Cavalcante, Moisés; Soares, Miguel P.. "Heme Oxygenase-1: A protective gene that regulates inflammation and immunity". In In Heme Oxygenase in Biology and Medicine: Emergence of the Products Carbon Monoxide, Iron and the Bile Pigments, edited by L.E. Otterbein; Brian S. Zuckerbraun, 141-171. United States: Nova Science Publishers Inc, 2005.
    Published
Conference poster
  1. Chora, Ângelo Ferreira; SILVA-SANTOS, Bruno; Tate, Ann T.; Maria Manuel Mota. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via gd T cells and IL-17-promoted stress erythropoiesis". Paper presented in 10th International Gamma Delta T cell Conference, 2023.
Journal article
  1. Chora, Ângelo Ferreira; Marques, Sofia; Gonçalves, Joana Lisboa; Lima, Priscila; Gomes da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria Inês; et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via gd T cells and IL-17-promoted stress erythropoiesis". Immunity 56 3 (2023): 592-605.e8. http://dx.doi.org/10.1016/j.immuni.2023.01.031.
    Open access • Published • 10.1016/j.immuni.2023.01.031
  2. Chora, Angelo Ferreira; Pedroso, Dora; Kyriakou, Eleni; Pejanovic, Nadja; Colaço, Henrique; Gozzelino, Raffaella; Barros, André; et al. "DNA damage independent inhibition of NF-kB transcription by anthracyclines". eLife 11 (2022): http://dx.doi.org/10.7554/elife.77443.
    Open access • Published • 10.7554/elife.77443
  3. Amichay Afriat; Vanessa Zuzarte-Luís; Keren Bahar Halpern; Lisa Buchauer; Sofia Marques; Ângelo Ferreira Chora; Aparajita Lahree; et al. "A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage". Nature (2022): https://doi.org/10.1038/s41586-022-05406-5.
    Open access • Published • 10.1038/s41586-022-05406-5
  4. Chora, Ângelo Ferreira; Mota, Maria M.; Prudêncio, Miguel. "The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle". International Journal for Parasitology 52 11 (2022): 711-715. http://dx.doi.org/10.1016/j.ijpara.2022.02.002.
    Open access • Published • 10.1016/j.ijpara.2022.02.002
  5. Mukherjee, Debanjan; Chora, Ângelo Ferreira; Lone, Jean-Christophe; Ramiro, Ricardo S.; Blankenhaus, Birte; Serre, Karine; Ramirez, Mário; et al. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-31301-8.
    Open access • Published • 10.1038/s41467-022-31301-8
  6. Meireles, Patrícia; Brás, Daniela; Fontinha, Diana; Chora, Ângelo F.; Serre, Karine; Mendes, António M.; Prudêncio, Miguel. "Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation". iScience 23 12 (2020): 101781. http://dx.doi.org/10.1016/j.isci.2020.101781.
    Open access • Published • 10.1016/j.isci.2020.101781
  7. Setua, Sonali; Enguita, Francisco J.; Chora, Ângelo Ferreira; Ranga-prasad, Harish; Lahree, Aparajita; Marques, Sofia; Sundaramurthy, Varadharajan; Mota, Maria M.. "Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells". Communications Biology 3 1 (2020): http://dx.doi.org/10.1038/s42003-020-01422-1.
    Open access • Published • 10.1038/s42003-020-01422-1
  8. Mukherjee, Debanjan; Chora, Ângelo Ferreira; Mota, Maria M.. "Microbiota, a Third Player in the Host–Plasmodium Affair". Trends in Parasitology 36 1 (2020): 11-18. http://dx.doi.org/10.1016/j.pt.2019.11.001.
    Open access • Published • 10.1016/j.pt.2019.11.001
  9. Zuzarte-Luís, Vanessa; Mello-Vieira, João; Marreiros, Inês M.; Liehl, Peter; Chora, Ângelo F.; Carret, Céline K.; Carvalho, Tânia; Mota, Maria M.. "Dietary alterations modulate susceptibility to Plasmodium infection". Nature Microbiology 2 12 (2017): 1600-1607. http://dx.doi.org/10.1038/s41564-017-0025-2.
    Open access • Published • 10.1038/s41564-017-0025-2
  10. Liehl, Peter; Zuzarte-Luís, Vanessa; Chan, Jennie; Zillinger, Thomas; Baptista, Fernanda; Carapau, Daniel; Konert, Madlen; et al. "Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection". Nature Medicine 20 1 (2013): 47-53. http://dx.doi.org/10.1038/nm.3424.
    Open access • Published • 10.1038/nm.3424
  11. Figueiredo, Nuno; Chora, Angelo; Raquel, Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; et al. "Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis". Immunity 39 5 (2013): 874-884. http://dx.doi.org/10.1016/j.immuni.2013.08.039.
    Open access • Published • 10.1016/j.immuni.2013.08.039
  12. Moita, Catarina F.; Chora, Ângelo; Hacohen, Nir; Moita, Luis F.. "RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells". European Journal of Immunology 42 7 (2012): 1843-1849. http://dx.doi.org/10.1002/eji.201142167.
    Open access • Published • 10.1002/eji.201142167
  13. Moura-Alves, Pedro; Neves-Costa, Ana; Raquel, Helena; Pacheco, Teresa Raquel; D'Almeida, Bruno; Rodrigues, Raquel; Cadima-Couto, Iris; et al. "An shRNA-Based Screen of Splicing Regulators Identifies SFRS3 as a Negative Regulator of IL-1ß Secretion". PLoS ONE 6 5 (2011): e19829. http://dx.doi.org/10.1371/journal.pone.0019829.
    Open access • Published • 10.1371/journal.pone.0019829
  14. Ferreira, Ana; Marguti, Ivo; Bechmann, Ingo; Jeney, Viktória; Chora, Ângelo; Palha, Nuno R.; Rebelo, Sofia; et al. "Sickle Hemoglobin Confers Tolerance to Plasmodium Infection". Cell 145 3 (2011): 398-409. http://dx.doi.org/10.1016/j.cell.2011.03.049.
    Open access • Published • 10.1016/j.cell.2011.03.049
  15. R. Larsen; R. Gozzelino; V. Jeney; L. Tokaji; F. A. Bozza; A. M. Japiassu; D. Bonaparte; et al. "A Central Role for Free Heme in the Pathogenesis of Severe Sepsis". Science Translational Medicine 2 51 (2010): 51ra71-51ra71. http://dx.doi.org/10.1126/scitranslmed.3001118.
    Open access • Published • 10.1126/scitranslmed.3001118
  16. Rodriguez, Sonia; Chora, Angelo; Goumnerov, Boyan; Mumaw, Christen; Goebel, W. Scott; Fernandez, Luis; Baydoun, Hasan; et al. "Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis". Blood 114 19 (2009): 4064-4076. http://dx.doi.org/10.1182/blood-2009-04-214916.
    Open access • Published • 10.1182/blood-2009-04-214916
  17. Silva, Gabriela; Jeney, Viktoria; Chora, Ângelo; Larsen, Rasmus; Balla, Jozsef; Soares, Miguel P.. "Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells". Journal of Biological Chemistry 284 43 (2009): 29582-29595. http://dx.doi.org/10.1074/jbc.m109.045344.
    Open access • Published • 10.1074/jbc.m109.045344
  18. Seixas, Elsa; Gozzelino, Raffaella; Chora, Ângelo; Ferreira, Ana; Silva, Gabriela; Larsen, Rasmus; Rebelo, Sofia; et al. "Heme oxygenase-1 affords protection against noncerebral forms of severe malaria". Proceedings of the National Academy of Sciences 106 37 (2009): 15837-15842. http://dx.doi.org/10.1073/pnas.0903419106.
    Open access • Published • 10.1073/pnas.0903419106
  19. Silva, G.; Jeney, V.; Chora, Â.; Larsen, R.; Balla, J.; Soares, M.P.. "Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells". Journal of Biological Chemistry 284 43 (2009): 29582-29595. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350418736&partnerID=MN8TOARS.
    10.1074/jbc.M109.045344
  20. Fernandez, Luis; Rodriguez, Sonia; Huang, Hui; Chora, Angelo; Fernandes, Jacquenilson; Mumaw, Christin; Cruz, Eugenia; et al. "Tumor necrosis factor-a and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation". Experimental Hematology 36 5 (2008): 545-558.e1. http://dx.doi.org/10.1016/j.exphem.2007.12.012.
    Open access • Published • 10.1016/j.exphem.2007.12.012
  21. Ana Pamplona; Ana Ferreira; József Balla; Viktória Jeney; György Balla; Sabrina Epiphanio; Ângelo Chora; et al. "Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria". Nat Med 13 6 (2007): 703-710. http://dx.doi.org/10.1038/nm1586.
    Open access • Published • 10.1038/nm1586
  22. Ângelo A. Chora; Paulo Fontoura; Andreia Cunha; Teresa F. Pais; Sílvia Cardoso; Peggy P. Ho; Lowen Y. Lee; et al. "Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation". J. Clin. Invest. 117 2 (2007): 438-447. http://dx.doi.org/10.1172/jci28844.
    Open access • Published • 10.1172/jci28844
  23. Zelenay, S.; Chora, A.; Soares, M.P.; Demengeot, J.. "Heme oxygenase-1 is not required for mouse regulatory T cell development and function". International Immunology 19 1 (2007): 11-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845901771&partnerID=MN8TOARS.
    Published • 10.1093/intimm/dxl116
  24. McDaid, J.; Yamashita, K.; Chora, A.; Öllinger, R.; Strom, T.B.; Li, X.C.; Bach, F.H.; Soares, M.P.. "Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells". FASEB Journal 19 3 (2005): 458-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644435685&partnerID=MN8TOARS.
    Published • 10.1096/fj.04-2217fje
  25. Fatima Cairrao; Angelo Chora; Rita Zilhao; Agamemnon J. Carpousis; Cecilia M. Arraiano. "RNase II levels change according to the growth conditions: characterization of gmr, a new Escherichia coli gene involved in the modulation of RNase II". Mol Microbiol 39 6 (2001): 1550-1561. http://dx.doi.org/10.1046/j.1365-2958.2001.02342.x.
    Open access • Published • 10.1046/j.1365-2958.2001.02342.x
Thesis / Dissertation
  1. Chora, Ângelo Ferreira. "Role of the protective gene Heme Oxygenase-1 in the control of T cell mediated responses". PhD, 2008. http://hdl.handle.net/10451/1160.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/27 Gamma Delta T cells: Fine-tuners of malaria pathology GD T cell Club Webinar Series
2023/02/24 Severe malaria: What's liver got to do with it? 9th McBiology Symposium
i3S (Porto, Portugal)
2022/05/24 Plasmodium cross-stage interplay dictates malaria outcome BioMalPar VXIII
European Molecular Biology Laboratory (EMBL) (Heidelberg, Germany)
2021/12/15 Plasmodium cross-stage interplay dictates malaria outcome New Voices in Infection Biology
Max Planck Institute for Infection Biology (Berlin, Germany)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Role of reticulocytes in the establishment of severe malaria
Supervisor of Mariana Vale Amaro de Sousa
 Master in Biomedical Research (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/10/01 - Current Plasmodium cross-stage interplay modulates parasite virulence
Co-supervisor of Sónia Maria Leite Pereira
 Biology at the host-microbe interface (PhD)
Instituto de Medicina Molecular, Portugal
2022/07/01 - 2024/03/08 Plasmodium determinants critical for the generation of pre-erythrocytic sterile immunity
Supervisor of Ana Catarina Salgueiro Rodrigues
 Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/01 - 2021/11/25 Immune-independent control mechanisms of Plasmodium parasite virulence
Supervisor of Marta Sofia Martinez Barata
 Biotechnology (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/25 New developments in whole-sporozoite vaccination against malaria
(Thesis) Arguer
 Diana Alves Moita (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/05/24 Tissue Damage Control in Autoimmune Diseases
(Thesis) Main arguer
 Vital Manuel da Silva Domingues (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/11/24 Comparative Efficacy Analysis of Whole-Sporozoite Vaccines Against Malaria
(Thesis) Main arguer
 Catarina Maria Vicente Rôla (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/25 The Dual Role of Heme Oxygenase 1 in Malaria
(Thesis) Main arguer
 Gil da Silva Pires (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/12/04 Evaluation of humoral and cellular immune responses to P. berghei-based whole sporozoite malaria vaccination in rhesus macaques
(Thesis) Main arguer
 Andreia Cunha Barreto (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/12/14 Immunogenicity and tumour microenvironment in the zebrafish xenograft model
(Thesis) Main arguer
 Mariana Maia Gil (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/11/12 Impact of Plasmodium infection on the expression of bradykinin-receptor 2 on trophoblasts
(Thesis) Main arguer
 André Filipe Rivais Martins Barateiro (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09/01 - Current Microbiology, Immunity and Infectiology Medicina (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2024/09/01 - Current Immunology Ciências da Nutrição (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal
2020/10/26 - 2020/10/26 Principles of Infection and Immunity / Plasmodium liver stage modulates malaria pathology Biomedical Research (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - 2022 PhD. Fellowships Call
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2021 - 2021 PhD. Fellowships Call
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2020/12/09 - 2020/12/09 FMUL Research Day
Evaluator
 Universidade de Lisboa Faculdade de Medicina, Portugal
Distinctions

Award

2013 Prémio Pfizer em Investigação Fundamental
Sociedade das Ciências Médicas de Lisboa, Portugal
2008 Prémio NEDAI em Autoimunidade
Sociedade Portuguesa de Medicina Interna, Portugal
2008 Prémio CITOMED em Imunologia
Associação Viver a Ciência, Portugal

Sociedade Portuguesa de Imunologia, Portugal

Other distinction

2003 Bolsa de Investigação GEMI Fund
Aga Linde Therapeutics, Sweden

Partners Harvard Medical International, United States

Karolinska Institutet, Sweden