Armanda Emanuela Castro e Santos (831D-49C2-5D9C)

Curriculum Vitae

Armanda Emanuela Castro e Santos

Armanda E. Santos has a degree in Pharmaceutical Sciences (1992, Best student Faculty of Pharmacy), a Master in Cell Biology (1995) and a PhD in Pharmacy (2003) by the University of Coimbra (UC). She initiated her academic career as Teaching Assistant (1994) at the Faculty of Pharmacy, UC, and become Assistant Professor in 2003. Currently, she is Associate Professor with tenure at the same university and teaches 5 distinct disciplines addressed to students of different courses of the Faculty of Pharmacy. In the past she was elected for several mandates of the Scientific Council and the Academic Title Equivalence Committee of the Faculty of Pharmacy. She is a senior researcher at the Cell Signaling and Metabolism in Disease group from the Center for Neuroscience and Cell Biology at UC. Her research has been focused on the study of molecular mechanisms involved in neurodegeneration, particularly those coupled to ionotropic glutamate receptors, aiming the identification of new therapeutic targets. Also, she developed chimeric peptides acting as selective ß-secretase inhibitors that may pave the way for a treatment of Alzheimer’s disease and is a co-inventor of a patent regarding these compounds. She was the principal investigator of 4 funded research projects, one of which was an award from Grupo de Estudos de Envelhecimento Cerebral e Demência, a Portuguese Scientific Society. She published 2 book chapters and 27 peer-reviewed articles and she is the first author or the last/correspondent author of 14 of them. Her publications have an accumulated impact factor of 117,32. She collaborates regularly as reviewer of international peer-reviewed journals and in 2021 she was associated editor of the Journal of Alzheimer’s Disease. She supervised/co-supervised 1 post-doc FCT researcher, 5 PhD students (5 concluded), 7 Science Master students (5 concluded), 13 students of the Master in Clinical Analysis (final reports), 39 students of the Integrated Master in Pharmaceutical Sciences (monographs) and 3 project’s fellows. She has also collaborated in the organization and teaching of advanced courses and seminars within the scope of PhD Programs at the UC and in scientific outreach activities. Moreover, she was a jury member of 14 PhD thesis, of 16 Science Master thesis, and of 99 final reports/monographs.

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Identification

Personal identification

Full name: Armanda Emanuela Castro e Santos

Citation names

Santos, Armanda E

Author identifiers

Ciência ID: 831D-49C2-5D9C
ORCID iD: 0000-0003-1111-2481

Email addresses

aesantos@ci.uc.pt (Professional)

Telephones

Telephone

239836354 (Professional)
239488400 (Professional)

Addresses

Faculdade de Farmácia, Universidade de Coimbra Faculdade de Farmácia da Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 , Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Intermediate (B1)
French	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Intermediate (B1)

Education

	Degree	Classification
2003 Concluded	Doutoramento em Ciências Farmacêuticas (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal "Eventos pós-receptor na neurotoxicidade do glutamato: contribuição da subunidade GluR4 dos receptores AMPA para a activação do factor de transcrição AP-1" (THESIS/DISSERTATION)	with honor/aprovada com distinção e louvor por una
1995 Concluded	Biologia Celular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Mecanismos de modulação pré-sináptica da libertação de GABA por receptores GABAB" (THESIS/DISSERTATION)	Very Good/Muito Bom
1992 Concluded	Ciências Farmacêuticas (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal "Internship Report" (THESIS/DISSERTATION)	16/20

Affiliation

Science

	Category Host institution	Employer
1992/10/01 - Current	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2003/11/25 - Current	Assistant Professor (University Teacher)	Universidade de Coimbra Faculdade de Farmácia, Portugal

1995/04 - 2003/11	Assistant (University Teacher)	Universidade de Coimbra, Portugal

1994/02 - 1995/03	Trainee Assistant (University Teacher)	Universidade de Coimbra, Portugal

Others

	Category Host institution	Employer
2008/01/01 - Current	Principal Investigator within the Cell Death and Neuroprotection group (until 2014)/Cell Signaling and Metabolism in Disease (2014-present) at the Center for Neuroscience and Cell Biology (CNC)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

1993/04/01 - 1994/02/01	M.Sc Fellow, (Programme Ciência)	Junta Nacional de Investigação Científica e Tecnológica (JNICT), Portugal

Projects

Contract

	Designation	Funders
2018 - 2022	InPaCtus - Innovative Products and Technologies from Eucalyptus COMPETE2020 nº 21874 Researcher	Concluded
2018 - 2021	Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease CENTRO-01-0145-FEDER-029369 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2021	The ups and downs of cellular stress: the MAM hypothesis for Bipolar disorder pathophysiology CENTRO-01-0145-FEDER-028214 Researcher	Fundação para a Ciência e a Tecnologia
2018 - 2021	Role of anthocyanins from Portuguese blueberries on gut-to-brain connection in autism spectrum disorder by using in vitro and in vivo models POCI-01-0145-FEDER-029089 Researcher	Fundação para a Ciência e a Tecnologia
2017 - 2020	HealthyAging2020 CENTRO-01-0145-FEDER-000012 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2019	Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos (Drugs2CAD) CENTRO-01-0247-FEDER-003269 Researcher	Centro 2020 Regional Operational Programme COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese Concluded
2017 - 2018	Valorization of the Thermal resorts of the Centre Region - Characterization of the bioactive potential of the thermal water resources of the Region - study of the therapeutic properties of thermal waters - dermocosmetic CENTRO-04-3928-FEDER-000010 Researcher	Concluded
2017 - 2018	Caracterização do potencial bioactivo dos recursos hídricos termais da região centro CENTRO-04-3928-FEDER-000010 Researcher
2013/06 - 2015/11	Tackling Alzheimer's Disease with a new peptide inhibitor of BACE1 PTDC/NEU-SCC/1351/2012 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2015	New Strategies to Manage Brain Diseases CENTRO-07-ST24-FEDER-002002 Researcher	Fundação para a Ciência e a Tecnologia
2012 - 2015	Desenvolvimento de um novo fármaco para o tratamento da doença de Alzheimer INC_2014_09_002_5645 Principal investigator	INOV.C - Sistemas de Bolsas de Ignição do Programa Estratégico Inov C, funded by QREN Concluded
2008 - 2011	Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type PTDC/SAU-NEU/099440/2008 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2006 - 2009	Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors PTDC/BIA-BCM/71789/2006 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2006 - 2009	Regulation of AMPA receptors by hyperglycemia in the retina PTDC/SAL-NEU/71228/2006 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2004 - 2007	Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors POCI/SAU-NEU/58955/2004 Researcher	Fundação para a Ciência e a Tecnologia
2004 - 2007	ATP and diabetic retinopathy: role on microglia regulation and on neuronal cell death POCI/SAU-NEU/59003/2004 Researcher	Fundação para a Ciência e a Tecnologia
2001 - 2004	Expression and functional characteristics of native and truncated forms of AMPA type glutamate receptor subunits POCTI/BCI/39127/2001 Researcher	Fundação para a Ciência e a Tecnologia

Other

	Designation	Funders
2017/07 - 2018/07	New BACE1 inhibitors for the treatment of Alzheimer's disease: an approach for the development of effective and safe substrate-selective inhibitors Bolsa de Investigação Edgar Cruz e Silva da edição 2016-2017 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Grupo de Estudos de Envelhecimento Cerebral e Demências com o patrocínio da Santa Casa da Misericórdia de Lisboa Concluded
2013 - 2015	Healthy ageing with innovative functional foods/leads for degenerative and metabolic diseases INOVAFUNAGEING Researcher	Fundação para a Ciência e a Tecnologia
2007 - 2009	Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Biogen Portugal Concluded

Outputs

Publications

Book chapter	Santos, Armanda. "Acidente vascular cerebral e isquemia neuronal". 2017. Santos, Armanda. "Mitochondrial Dysfunction on the Toxic Effects of Anticancer Agents". In Toxicology Studies - Cells, Drugs and Environment, 23-59. Editor Ana Cristina Andreazza and Gustavo Scola, From Lab Bench to Bedside., 2015. Published
Conference poster	Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Novel Glutaminyl Cyclase Inhibitors Discovered by Molecular Modeling Studies". Paper presented in 8th EFMC Young Medicinal Chemists’ Symposium (EFMC-YMCS 2021), 2021. Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; Jorge A. R. Salvador, Salvador, J.. "A Virtual Screening Protocol to Identify Novel Inhibitors of Glutaminyl Cyclase". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMCISMC 2021, 2021. Silva, Ana Cristina Rosa da; Pereira, Marta ; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER’S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021. Coimbra, Judite RM; Baptista, Salete J.; Silva, MMC; Dinis, Teresa; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Application of Computational Methods for Discovery of Novel BACE1 Hit Inhibitors: Ligand- and Structure-based Protocols with In Vitro Evaluation". Paper presented in the 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, 2020. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Moreira, Patricia; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "Targeting Alzheimer´s Disease: A Virtual Screening Protocol to Discover New Central-Acting BACE1 Inhibitors". Paper presented in Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, 2019. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Moreira, Patricia; Silva, MMC; Dinis, Teresa; SALVADOR, J.A.R.. "Targeting Alzheimer´s Disease: An Integrated Protocol of Virtual Screening for Discovery of Novel Anti-BACE1 Agents". Paper presented in AD/PDTM 2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2019. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019. Silva, Ana Cristina Rosa da; Pereira, Marta; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, MMC; et al. "Skin allergens and Alzheimer´s disease: preliminar studies on na (im)probable link". Paper presented in . 8th ECS workshop Calcium Signalin in Aging and Neurodegenerative Diseases, 2019. Pereira, Marta; Silva, Ana Cristina Rosa da; Neves, Bruno; Moreira, Patricia; Silva, MMC; Santos, Armanda E; Pereira, Cláudia; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer´s disease". Paper presented in Ageing: models, mechanisms and therapies, 2019. Resende, Rosa; Moreira, Patricia; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, F.; Sereno, J.; Abrunhosa, Antero; et al. "New chimeric peptides selectively inhibit APPß cleavage Decreasing Aß formation and accumulation in AD models". Paper presented in AD/PDTM 2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2019. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "Identification of Novel BACE1 Inhibitors: A Combined Protocol of Pharmacophore Modeling, Virtual Screening and Structure-based Drug Design". Paper presented in XXV EFMC International Symposium on Medicinal Chemistry, 2018. Coimbra, Judite RM; Baptista, Salete J.; Santos, Armanda E; Silva, MMC; Dinis, Teresa; Jorge A. R. Salvador, Salvador, J.. "New BACE I Inhibitors: A Structure-based and Ligand-based Rational Drug Design. Pharmacophore Modeling and Virtual Screening". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, F; Sereno, J; Abrunhosa, Antero; Castelo-Branco, Miguel; Pereira, Cláudia; Santos, Armanda E. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xTg-AD mouse model". Paper presented in 13th International Conference on Alzheimer’s & Parkinson Diseases, 2017. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Oliveira, F; Sereno, J; Abrunhosa, Antero; Castelo-Branco, Miguel; Pereira, Cláudia; Santos, Armanda E. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xTg-AD mouse model". Paper presented in XIX Congresso Nacional de Bioquímica, 2016. Resende, Rosa; Ferreira-Marques, Marisa; Dinis, Teresa; Pereira, Cláudia; Santos, Armanda E. "New BACE1 inhibitors decrease Aß production and accumulation in the 3xtg-ad mouse model". Paper presented in 1st Symposium on Aging Research @CNC - Molecular mechanisms of aging and age-related diseases, 2016. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "New BACE1 inhibitors for Alzheimer´s disease treatment.". Paper presented in 19th European Synposium on Organyc Chemistry (ESOC 2015), 2015. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "Tackling Alzheimer´s disease with a new inhibitor of BACE1: evaluation of peptide efficiency in vitro and in an in vivo model of AD". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015. Ferreira-Marques, Marisa; Resende, Rosa; Pereira, Cláudia; Dinis, Teresa; Santos, Armanda E. "Tackling Alzheimer´s disease with a new inhibitor of BACE1: evaluation of compound efficacy in vitro and in a celular model of AD". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014. Vieira, M; Fernandes, J; Carreto, L; Anuncibay-Soto, B.; Santos, M; Fernández-López, A.; Han, J; et al. "Ischemic insults induce an up-regulation of RIP3 eliciting necroptosis in hippocampal neurons". Paper presented in Gordon Research Conference Neurobiology of Brain Disorders – Neurodegeneration and Aging-Related Disorders of the Nervous System, 2014. Ribeiro, Mariana P C; Santos, Armanda E; Custódio, José B A. "The tamoxifen active metabolites endoxifen and 4-hydroxytamoxifen present superior antitumor activity over the pro-drug in malignant melanoma". Paper presented in European Cancer Congress 2013 (ECCO-ESMO-ESTRO), 2013. Ribeiro, Mariana P C; Santos, Armanda E; Custódio, José B A. "Synergistic effects of glutamate receptors antagonists combined with antiestrogens on melanoma cells". Paper presented in European Cancer Congress 2013 (ECCO-ESMO-ESTRO), 2013. Ribeiro, Mariana P C; Santos, Armanda E; Custódio, José B A. "The combination of all-trans-retinoic acid with endoxifen is a promising strategy for melanoma treatment". Paper presented in EMBO Young Scientists´ Forum, 2013. Fernandes, J; Vieira, M; Carreto, L; Santos, M; Duarte, C B; Carvalho, A L; Santos, Armanda E. "In vitro ischemia in hippocampal neurons triggers a transcriptional response to down-regulate synaptic proteins". Paper presented in Annual Meeting, Center for Neuroscience and Cell Biology, 2012. Ribeiro, Mariana P C; Silva, F S G; Sousa, M C; Santos, Armanda E; Custódio, José B A. "Antitumor effects of retinoic acid combined with antiestrogens on melanoma cells". Paper presented in 22nd Biennal Congress of the European Association for Cancer Research: From basic Research to personalised cancer treatment, 2012. Ribeiro, Mariana P C; Santos, Armanda E; Custódio, José B A. "N-Methyl-D-aspartate receptor antagonists suppress the growth of melanoma cells". Paper presented in 22nd Biennal Congress of the European Association for Cancer Research: From basic Research to personalised cancer treatment, 2012. Fernandes, J; Vieira, M; Carreto, L; Santos, M; Duarte, C B; Carvalho, A L; Santos, Armanda E. "In vitro ischemia in hippocampal neurons triggers a transcriptional response to down-regulate synaptic proteins". Paper presented in 8th FENS Forum of Neuroscience, 2012. Ribeiro, Mariana P C; Silva, F S G; Santos, M S; Santos, Armanda E; Custódio, José B A. "The antiestrogen endoxifen is a potent inhibitor of mitochondrial permeability transition.". Paper presented in XXI Porto Cancer Meeting: Metabolism and Cancer, from etiopathogenesis to therapy, 2012. Ribeiro, Mariana P C; Silva, F S G; Santos, Armanda E; Custódio, José B A. "Effects of endoxifen on mitochondrial functions.". Paper presented in International Society of Antioxidants in Nutrion & Health, 2011. Vieira, M; Fernandes, J; Burgeiro, A.; Duarte, C B; Carvalho, A L; Santos, Armanda E. "Coupling of Ca2+-permeable AMPA Receptors to the JNK and p38 Signalling Pathways: Implications for Cerebral Global Ischemia". Paper presented in 8th IBRO World Congress of Neuroscience, 2011. Fernandes, J; Vieira, M; Duarte, C B; Carvalho, A L; Santos, Armanda E. "Role of Ca2+-Permeable AMPA Receptors in ischemia: characterization of the OGD-induced cell death and genetic expression profile of the ischemic response". Paper presented in 8th IBRO World Congress of Neuroscience, 2011. Vieira, M; Fernandes, J; Burgeiro, A.; Duarte, C B; Carvalho, A L; Santos, Armanda E. "Excitotoxic pathways downstream Ca2+-permeable AMPA Receptors: the role of JNK and p38 MAP kinases". Paper presented in 5th Annual Meeting on Cell Signalling, 2011. Ribeiro, Mariana P C; Silva, F S G; Sousa, M C; Santos, Armanda E; Custódio, José B A. "Retinoids and Antiestrogens: a new combined therapy for cancer treatment?". Paper presented in XX Porto Cancer Meeting, 2011. Ribeiro, Mariana P C; Silva, F S G; Santos, Armanda E; Custódio, José B A. "The combination of antiestrogens with retinoic acid does not enhance the toxic effects induced by the retinoid on bioenergetic functions". Paper presented in XVII Congresso Nacional de Bioquímica, 2010. Vieira, M; Fernandes, J; Burgeiro, A; Thomas, G M; Huganir, R L; Duarte, C B; Carvalho, A L; Santos, Armanda E. "Ca2+-permeable AMPA receptor overstimulation activates the JNK pathway: a possible role for JIP-1 in the excitotoxic signal propagation". Paper presented in 7th FENS Forum of European Neuroscience, 2010.
Journal article	Coimbra, Judite R.M.; Resende, Rosa; Custódio, José B.A.; Salvador, Jorge A.R.; Santos, Armanda E.. "BACE1 Inhibitors for Alzheimer’s Disease: Current Challenges and Future Perspectives". Journal of Alzheimer's Disease 101 s1 (2024): S53-S78. http://dx.doi.org/10.3233/jad-240146. 10.3233/jad-240146 Ana Silva; Sónia Silva; Jéssica Macedo; Patrícia Moreira; Diana Baptista; Joana Bicker; Ana Fortuna; et al. "Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol.". (2024): https://doi.org/10.32388/LUXM7W. Submitted Beatriz Rodrigues; Eduarda Ventura; Patrícia Moreira; Rosa Resende; Joana Bicker; Santos, Armanda E; Cláudia Fragão Pereira; et al. "New Low-Dose Curcumin Derivative with Therapeutic Potential in Alzheimer’s Disease". Free Radical Biology and Medicine (2024): Submitted Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R.. "Therapeutic potential of glutaminyl cyclases: Current status and emerging trends". Drug Discovery Today 28 10 (2023): 103644. http://dx.doi.org/10.1016/j.drudis.2023.103644. 10.1016/j.drudis.2023.103644 Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease". Biomedicines 9 8 (2021): 881. http://dx.doi.org/10.3390/biomedicines9080881. 10.3390/biomedicines9080881 Santos, Armanda. "Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens Targeting the Nrf2 Signaling Pathway in Alzheimer’s Disease Cellular Models". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/20/7791. 10.3390/ijms21207791 Santos, Armanda E. "New BACE1 chimeric peptide inhibitors selectively prevent AßPP-ß cleavage decreasing Aß production and accumulation in AD models". Journal of Alzheimers Disease (2020): https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200381. 10.3233/JAD-200381 Judite R. M. Coimbra; Salete J. Baptista; Teresa C. P. Dinis; Maria M. C. Silva; Paula I. Moreira; Armanda E. Santos; Jorge A. R. Salvador. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535-535. https://doi.org/10.3390/biom10040535. 10.3390/biom10040535 Pereira, C.F.; Santos, A.E.; Moreira, P.I.; Pereira, A.C.; Sousa, F.J.; Cardoso, S.M.; Cruz, M.T.. "Is Alzheimer's disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072809334&partnerID=MN8TOARS. 10.1016/j.arr.2019.100966 Coimbra, J.R.M.; Sobral, P.J.M.; Santos, A.E.; Moreira, P.I.; Salvador, J.A.R.. "An overview of glutaminyl cyclase inhibitors for Alzheimer's disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076529321&partnerID=MN8TOARS. 10.4155/fmc-2019-0163 Santos, Armanda. "Polyphenolic characterization and bioactivity of an Oxalis pes-caprae L. leaf extract.". Natural Product Research (2018): https://www.ncbi.nlm.nih.gov/pubmed/28627294. 10.1080/14786419.2017.1335728 Coimbra, J.R.M.; Marques, D.F.F.; Baptista, S.J.; Pereira, C.M.F.; Moreira, P.I.; Dinis, T.C.P.; Santos, A.E.; Salvador, J.A.R.. "Highlights in BACE1 inhibitors for Alzheimer's disease treatment". Frontiers in Chemistry 6 MAY (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048225310&partnerID=MN8TOARS. 10.3389/fchem.2018.00178 Mariana P.C. Ribeiro; Armanda E. Santos; José B.A. Custódio. "The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells". Chemico-Biological Interactions 277 (2017): 176-184. https://doi.org/10.1016/j.cbi.2017.09.017. 10.1016/j.cbi.2017.09.017 Ribeiro, M.P.C.; Custódio, J.B.A.; Santos, A.E.. "Ionotropic glutamate receptor antagonists and cancer therapy: time to think out of the box?". Cancer Chemotherapy and Pharmacology 79 2 (2017): 219-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984821839&partnerID=MN8TOARS. 10.1007/s00280-016-3129-0 Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia". Neurobiology of Disease 89 (2016): 223-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS. 10.1016/j.nbd.2015.11.007 Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A.. "Rethinking tamoxifen in the management of melanoma: New answers for an old question". European Journal of Pharmacology 764 (2015): 372-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937509486&partnerID=MN8TOARS. 10.1016/j.ejphar.2015.07.023 Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E.. "In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons". PLoS ONE 9 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS. 10.1371/journal.pone.0099958 Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al. "Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3". Neurobiology of Disease 68 (2014): 26-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS. 10.1016/j.nbd.2014.04.002 Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A.. "Mitochondria: The gateway for tamoxifen-induced liver injury". Toxicology 323 (2014): 10-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902357447&partnerID=MN8TOARS. 10.1016/j.tox.2014.05.009 Ribeiro, M.P.C.; Santos, A.E.; Custódio, J.B.A.. "Interplay between estrogen and retinoid signaling in breast cancer - Current and future perspectives". Cancer Letters 353 1 (2014): 17-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908364519&partnerID=MN8TOARS. 10.1016/j.canlet.2014.07.009 Ribeiro, M.P.C.; Nunes-Correia, I.; Santos, A.E.; Custódio, J.B.A.. "The combination of glutamate receptor antagonist MK-801 with tamoxifen and its active metabolites potentiates their antiproliferative activity in mouse melanoma K1735-M2 cells". Experimental Cell Research 321 2 (2014): 288-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895063788&partnerID=MN8TOARS. 10.1016/j.yexcr.2013.11.002 Ribeiro, M.P.C.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A.. "Effects of all-trans-retinoic acid on the permeability transition and bioenergetic functions of rat liver mitochondria in combination with endoxifen". Life Sciences 93 2-3 (2013): 96-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880250995&partnerID=MN8TOARS. 10.1016/j.lfs.2013.05.027 Ribeiro, M.P.C.; Silva, F.S.G.; Santos, A.E.; Santos, M.S.; Custódio, J.B.A.. "The antiestrogen endoxifen protects rat liver mitochondria from permeability transition pore opening and oxidative stress at concentrations that do not affect the phosphorylation efficiency". Toxicology and Applied Pharmacology 267 1 (2013): 104-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872252817&partnerID=MN8TOARS. 10.1016/j.taap.2012.12.012 Ribeiro, M.P.C.; Silva, F.S.G.; Paixão, J.; Santos, A.E.; Custódio, J.B.A.. "The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells". European Journal of Pharmacology 715 1-3 (2013): 354-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885471345&partnerID=MN8TOARS. 10.1016/j.ejphar.2013.04.038 Lobo, A.C.; Gomes, J.R.; Catarino, T.; Mele, M.; Fernandez, P.; Inácio, A.R.; Bahr, B.A.; et al. "Cleavage of the vesicular glutamate transporters under excitotoxic conditions". Neurobiology of Disease 44 3 (2011): 292-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053269066&partnerID=MN8TOARS. 10.1016/j.nbd.2011.07.010 Vieira, M.; Fernandes, J.; Burgeiro, A.; Thomas, G.M.; Huganir, R.L.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E.. "Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+dependent JNK activation". Neurobiology of Disease 40 3 (2010): 645-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957795389&partnerID=MN8TOARS. 10.1016/j.nbd.2010.08.008 Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L.. "Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor". Cell Death and Differentiation 13 4 (2006): 652-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS. 10.1038/sj.cdd.4401785 Santos, A.E.; Carvalho, A.L.; Lopes, M.C.; Carvalho, A.P.. "Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal Neurons". Journal of Neuroscience Research 66 4 (2001): 643-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889524&partnerID=MN8TOARS. 10.1002/jnr.10036 Santos, A.E.; Laranjinha, J.A.N.; Almeida, L.M.. "Sulfonated Chloroaluminum Phthalocyanine Incorporates into Human Plasma Lipoproteins: Photooxidation of Low-Density Lipoproteins". Photochemistry and Photobiology 67 4 (1998): 378-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032040364&partnerID=MN8TOARS. Santos, A.E.; Carvalho, C.M.; Macedo, T.A.; Carvalho, A.P.. "Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes". Neurochemistry International 27 4-5 (1995): 397-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028981911&partnerID=MN8TOARS. 10.1016/0197-0186(95)00021-Y
Thesis / Dissertation	Santos, Armanda. "Eventos pós-receptor na neurotoxicidade do glutamato: contribuição da subunidade GluR4 dos receptores AMPA para a activação do factor de transcrição AP-1". PhD, Universidade de Coimbra Faculdade de Farmácia, 2003. Santos, Armanda. "Mecanismos de modulação pré-sináptica da libertação de GABA por receptores GABAB". Master, Universidade de Coimbra Faculdade de Farmácia, 1995.

Intellectual property

Patent

Santos, Armanda; Rosa Maria Branco de Matos Costa Resende; Cláudia Maria Fragão Pereira ; Ferreira-Marques, Marisa; Teresa Pimenta Dinis Silva. 2021. "Peptídeos Inibidores da BACE1 para o Tratamento de doenças neurológicas". Portugal.
Allowed

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/02/03	Development of a curcumin derivative: impacto n neuroinflammation and ¿-amyloid plaques in Alzheimer’s disease celular models	Quinquagésima terceira Reunião da Sociedade Portuguesa de Farmacologia, Quadragésima primeira Reunião de Farmacologia Clínica e Vigésima segunda Reunião de Toxicologia (Coimbra, Portugal)
2023/02/01	“(S)-(+)-Carvone modulates macrophage polarization	Quinquagésima terceira Reunião da Sociedade Portuguesa de Farmacologia, Quadragésima primeira Reunião de Farmacologia Clínica e Vigésima segunda Reunião de Toxicologia (Coimbra, Portugal)
2020	Electrophilic molecules with anti-inflammatory and neuroprotective properties	Reunião da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica, XIX reunião de Toxicologia, Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2020	New BACE1 chimeric peptide inhibitors selectively prevent APP-ß cleavage decreasing Aß production and accumulation in AD models	I Retiro Científico da área de Metabolism, Aging and Disease (CNC.IBILI) (Coimbra, Portugal)
2019	In Silico Prediction and In Vitro Evaluation of New BACE1 Inhibitors for Alzheimer’s Disease	CIBB Meeting 2019 (Coimbra, Portugal)
2019	Endoplasmic reticulum and mitochondrial stress responses in neuronal cells in the context of Alzheimer’s disease	XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia
2018/10/13	Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease.	32nd GEECD MEETING Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2018/03/16	Novos inibidores da BACE1 para o tratamento da doença de Alzheimer	XIX SIMPÓSIO NEF/AAC, Faculty of Pharmacy, University of Coimbra Faculty of Pharmacy, University of Coimbra (Coimbra, Portugal)
2018	New chimeric peptides selectively inhibit APP-ß cleavage	32ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
2017/11/08	New strategies to target BACE1: towards Alzheimer's disease treatment.	Seminar within the scope of the Master in Biomedical Research, Faculty of Medicine Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2017/02/02	New peptide inhibitors of BACE1: towards Alzheimer's disease treatment	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia Fundação Bissaya Barreto (Portugal)
2017	New peptide inhibitors of BACE1: towards Alzheimer's disease treatment	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia, (Coimbra, Portugal)
2016/11/10	Peptide inhibitors of BACE1 for the treatment of neurological disorders.	Seminar within the scope of the Master in Biomedical Research, Faculty of Medicine, Faculty of Medicine, University of Coimbra, Coimbra, (Coimbra, Portugal)
2016/06/25	Avaliação de moléculas com potencial interesse como terapêutica para a Doença de Alzheimer	Seminar within the scope of the Master in Applied Pharmacology, Faculty of Pharmacy, University of Coimbra, Faculty of Pharmacy, University of Coimbra, (Coimbra, Portugal)
2016/06/03	New BACE1 inhibitors decrease Aß production in cellular and in vivo models of Alzheimer’s disease	30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência Hotel Açores, Lisboa, Portugal.
2016	New BACE1 inhibitors for Alzheimer’s disease treatment: evaluation of their efficacy in in vitro and in vivo models.	XV EPI, 15th Iberian Peptide Meeting (Porto, Portugal)
2015	New promising peptides to inhibit BACE1: evaluation of compound efficiency in cellular and mouse models of Alzheimer´s disease	9ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (Aveiro, Portugal)
2015	BACE1 inhibition as a promising therapy for AD	Apresentação incluída no âmbito da disciplina de “Projecto Integrado Multidisciplinar” do Mestrado em Investigação Biomédica Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2014	Mecanismos de morte neuronal induzidos por isquemia cerebral	VIII Congresso Científico do NEF/AAC “Cérebro e (Dis)Funções” 6-7 November, Faculdade de Farmácia, Universidade de Coimbra Faculdade de Farmácia, Universidade de Coimbra (Coimbra, Portugal)
2013	In vitro ischemia in hippocampal neurons triggers a transcriptional response to down-regulate synaptic proteins.	XIII Reunião da Sociedade Portuguesa de Neurociências (Junho, Portugal)
2013	Necroptotic neuronal death of hippocampal neurons submitted to an ischemic stimulus	XIII Reunião da Sociedade Portuguesa de Neurociências (Luso)
2013	Neuronal death mediated by glutamate receptors	Seminário incluído no âmbito da disciplina de Farmacologia II da Licenciatura em Química Medicinal Faculty of Sciences and Technology, University of Coimbra (Coimbra, Portugal)
2012	Necroptotic neuronal death in an in vitro model of cerebral ischemia	X Annual Meeting, Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2012	Endoxifen is a less toxic alternative to tamoxifen	XLII Reunião Anual da Sociedade Portuguesa de Farmacologia; XXX Reunião de Farmacologia Clínica; XI Reunião de Toxicologia (Lisboa, Portugal)
2011/11/02	Morte de neurónios mediada por receptores do glutamato	Faculdade de Farmácia, Universidade de Coimbra, Faculdade de Farmácia, Universidade de Coimbra, (Portugal)
2011	The combination of retinoic acid with antiestrogens is a promising approach for melanoma treatment	Meeting of CNC (coimbra, Portugal)
2011	The role of the JNK/c-Jun pathway in excitotoxicity mediated through Ca2+-permeable AMPA receptors: implications for cerebral global ischemia	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia (Coimbra, Portugal)
2011	Combined anticancer therapies: an analysis of mitochondrial functions under the use of antiestrogens and retinoic acid	XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia (Coimbra, Portugal)
2010	Antiestrogens Tamoxifen and 4-Hydroxytamoxifen prevent the mitochondrial permeability transition induced by Retinoic Acid	International Courses on Toxicology: Survival or death as a matter of fat (Coimbra, Portugal)
2007/10/01	Excitotoxic mechanisms mediated by Ca2+-permeable AMPA receptors	Columbia University Medical Center, New York, USA; (United States)
2003/06/11	Excitotoxic pathways coupled to GluR4-containing AMPA receptors activate the AP-1 transcription factor	8th Meeting of the Portuguese Society for Neuroscience
2002	The AP-1 transcription factor is activated in excitotoxic conditions in GluR4-expressing HEK 293 cells	Society for Neuroscience Annual Meeting (Orlando, United States)
1994	Modulation of [Ca2+]i and neurotransmitter relase by presynaptic receptors	II Congresso Nacional de Neurociências (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023 - 2024	Síntese de Compostos Macrocíclicos Derivados de Isatina e Avaliação para a doença de Alzheimer Co-supervisor	Industrial Pharmaceutical Chemistry (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2023 - 2024	Novos inibidores da glutaminil ciclase no tratamento da doença de Alzheimer Co-supervisor	Industrial Pharmaceutical Chemistry (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2023/06/19	“Rational drug design of novel potent multifunctional agents for alzheimer’s disease treatment”. Co-supervisor	Pharmaceutical Chemistry (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2021	Evaluation of the ability of CIAD7, a natural compound, to induce the pro-resolution phenotype in murine macrophages Supervisor	Mestrado em Biotecnologia Farmacêutica (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2019	Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1 Supervisor	Supervision of Research Assistants (Other) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2019	Exosome-mediated glia-neuronal crosstalk upon inflammasome activation in AD Co-supervisor	Post Doc supervision (Other) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2018	Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1 Supervisor	Post Doc supervision (Other) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2017	Biological effects of a new BACE1 inhibitors for Alzheimer’s disease treatment Supervisor	Master in Biomedical Engeneering (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2017	Design and preparation of new BACE1 inhibitors for Alzheimer’s disease treatment Co-supervisor	Master in Industrial Pharmaceutical Chemistry (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2016	Regulation of Local Translation by BDNF: Effects on NMDA Receptor Trafficking Co-supervisor	Doutoramento em Ciências Farmacêuticas (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015	Tackling Alzheimer’s Disease with a new peptide inhibitor of BACE1 Supervisor	Supervision of Research Assistants (Other) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2014	In vitro ischemia-induced changes in the transcriptome of hippocampal neurons: Neuroprotective pathways in brain ischemia Supervisor	Doutoramento em Ciências e Tecnologias da Saúde (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2014	Treatment strategies for melanoma: pharmacological and toxicological action mechanisms of combined therapy Co-supervisor	Doutoramento em Ciências Farmacêuticas (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - 2014	Molecular Mechanisms Underlying in vitro Cerebral Ischemia: Multiple Neuronal Death Pathways Supervisor	Doutoramento em Ciências e Tecnologias da Saúde (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2009	Role of Ca2+-Permeable AMPA receptors in excitotoxicity: contribution of GluR4 subunit phosphorylation and characterization of the OGD-induced cell death Supervisor	Master in Molecular and Cell Biology (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2008	Excitotoxic mechanisms associated to Ca2+-permeable AMPA receptors: the role of the JNK pathway Supervisor	Master in Molecular and Cell Biology (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2022/04/04 - 2022/04/08	Advanced Course - Metabolic and inflammatory drivers in age-related neurodegenerative diseases - Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2022/04/04 - 2022/04/08)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/08 - 2019/04/12	Advanced Course - Neurodegenerative Disorders - Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2019)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/10/19 - 2011/10/21	Advanced Course -Excitotoxic Signaling - Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2011)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/10/20 - 2011/10/20	Seminar organization Centro de Neurociências e Biologia Celular, UC - Delineation of Neurodegenerative Signalling Pathways , Michael J Courtney, Virtanen Institute, University of Eastern Finland, Kuopio, Finland, (2011 - 2011) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/01/30 - 2009/01/30	Seminar organization, Centro de Neurociências e Biologia Celular, UC - Protein interactions : possible therapeutic targets for neurodegenerative diseases, Michael J Courtney, Virtanen Institute, University of Eastern Finland, Kuopio, Finland. (2009) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/01/26 - 2009/01/30	Advanced course "Cell Death" Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2009)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/01/25 - 2008/01/25	Seminar organization, Centro de Neurociências e Biologia Celular, UC: The role of the AP-1 transcription factors and their target genes in developmental cell death,, Jonathan Ham, Institute of Child Health, University College London, London, UK. (2008) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/01/21 - 2008/01/25	Advanced course "Cell Death", Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2008)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/19 - 2007/01/19	Seminar organization, Centro de Neurociências e Biologia Celular, UC: How do neurons die in neurodegenerative disorders and how can we prevent this? Insights from cellular models, Lloyd Greene, Columbia University Medical Center, NY, USA. (2007) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/15 - 2007/01/19	Advanced course "Death and survival signalling", Programa Doutoral em Biologia Experimental e Biomedicina, Centro de Neurociências e Biologia Celular, UC (2007)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/06/17 - 2005/06/17	Seminar organization, Centro de Neurociências e Biologia Celular, UC: Anti-apoptotic and stem cell strategies for perinatal brain repair, Huseyin Mehmet, Weston Laboratory, Faculty of Medicine, Imperial College London, UK (2005) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/11/05 - 2004/11/05	Seminar organization, Centro de Neurociências e Biologia Celular, UC: Pathology of the glutamatergic synapse, Rita Sattler, Department of Neurology Johns Hopkins University School of Medicine, Baltimore, USA. (2004) Seminar (Member of the Organising Committee)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2021/12/16	Evaluation of the ability of CIAD7, a natural compound, to induce the pro-resolution phenotype in murine macrophages Supervisor	Inês Alexandra Ferreira Rodrigues (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/04/30	Role of TOMM40’523 – APOE haplotypes in alzheimer’s disease etiology – from clinics to mitochondria (Thesis) Main arguer	Rémy Cardoso (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09/11	Adjuvantes à base de ß-glucano aplicados à vacinação contra a hepatite B: desenho de formas particuladas para suprir as necessidades profilácticas e terapêuticas Thesis Member	Edna Filipa Pais Soares (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/02/09	Protective role of anthocyanins on intestinal inflammation in comparison with 5-aminosalicylic aid: in vitro and in vivo approaches (Thesis) Arguer	Sónia Margarida Neto Rosa Pereira (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/27	Biological effects of new BACE1 inhibitors for Alzheimer’s disease treatment Supervisor	Verónica Resende Figueiredo (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/24	The role of autophagy in the differential vulnerability and integrated stress response to cerebral ischemia (Thesis) Arguer	Diego Pérez Rodríguez (PhD) Universidade de Leon - Faculty of Biological and Environmental Sciences, Spain
2017/06/29	Role of actin regulatory proteins in tunneling nanotubes formation and intercelular transfer in HeLa cells (Thesis) Main arguer	Miguel Jorge Macedo Lemos (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/06/09	Unravelling the role of ataxin-2 in the hypothalamus: a new player in metabolism President of the jury	Sara Matias Carmo Silva (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/02/24	Défice Cognitivo Ligeiro e Doença de Alzheimer: as diferenças numa perspetiva proteómica Thesis Member	Ana Karolina Seco das Neves Freitas (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/05/20	Regulation of Local Translation by BDNF: Effects on NMDA Receptor Trafficking Supervisor	Pedro João Madeira Afonso (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09/09	Alteration of GABAAR trtafficking in epilepsy (Thesis) Main arguer	Ricardo da Costa Barbedo Vieira (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2014/12/11	Changes in components of the brain extracelular matrix after experimental ischemic stroke (Thesis) Main arguer	Carla Sofia de Jesus Guerreiro (Master) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2014/09/19	Alteration of GABAAR trafficking during cerebral ischemia: the role of Huntingtin-associated protein 1 (Thesis) Main arguer	Maria Cristina Aspromonte (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/24	In vitro ischemia-induced changes in the transcriptome of hippocampal neurons: Neuroprotective pathways in brain ischemia Supervisor	Joana Filipa Coelho Fernandes (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/07/01	Molecular Mechanisms Underlying in vitro Cerebral Ischemia: Multiple Neuronal Death Pathways Supervisor	Marta Isabel Dias da Mota Vieira (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/07/26	Stress, depression and adrenal gland: an insight into the adrenal medullary cathecolamnergic system (Thesis) Arguer	Magda Matos Santana (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/03/26	The role of calpains on TrkB and Gephyrin cleavage under excitotoxic conditions: characterization and functional implications Thesis Member	João Manuel Trigueiro Costa (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/03/06	Papel das antocianinas no contexto da prevenção da aterosclerose: mecanismos moleculares de protecção contra a apoptose e inflamação em células endoteliais Thesis Member	Joana Isabel Félix Paixão (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/31	Influência das horas de sono no desenvolvimento da obesidade: um estudo na farmácia comunitária (Thesis) Main arguer	Zita Manuela Carvalho Machado (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/09/10	Neuronal changes under excitotoxic conditions – the role of 26S proteasome (Thesis) Main arguer	Ivan Lalanda Salazar (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/07/31	Regulação dos receptores AMPA pela hiperglicemia na retina (Thesis) Arguer	Áurea Filipa de Aguiar Castilho (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/12/05	Tauroursodeoxycholic acid: a novel neuroprotective drug in diabetic retinopathy (Thesis) Main arguer	Alexandra Menezes Martins (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2011/09/08	Retrograde-induced cell death: Role of proNGF (Thesis) Main arguer	Tânia Marisa Melim Perestrelo (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/06/29	Heterogeneidade Genética Intratumoral de Gliomas: avaliação através de iFISH sobre núcleos interfásicos e ‘arrays’ de cDNA: impacto no comportamento clínico e biológico da doença Thesis Member	Ana Luísa Vital Castanheira de Carvalho (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/09/17	25-Hydroxycholesterol increases IL-8 production in retinal pigment epithelial cells by activation of PI3K and ERK pathways (Thesis) Main arguer	Eliana Filipa da Silva Murteira (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09/14	Role of Ca2+-Permeable AMPA Receptors in Excitotoxicity: Contribution of GluR4 subunit phosphorylation and characterization of the OGD-induced cell death Supervisor	Joana Filipa Coelho Fernandes (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/12/03	Efeito da glucose elevada no conteúdo de receptores AMPA na retina e no hipocampo (Thesis) Main arguer	Joana Manuela Torres Liberal (Master) Universidade de Aveiro Departamento de Biologia, Portugal
2008/09/16	Excitotoxic Mechanisms Associated to Ca2+-Permeable AMPA Receptors: the role of the JNK Signaling Pathway Supervisor	Marta Isabel Dias da Mota Vieira (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/06/30	Mechanisms of retinal neurodegeneration in the early stages of diabetic retinopathy: the involvement of glutamate Thesis Member	Ana Raquel Sarabando Santiago, (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2023/03/10 - 2033/03/10	Cells (MDPI)	MDPI
2023/03/08 - 2023/03/08	Peer J	Peer J Publishing
2022/11/14 - 2022/11/14	International Journal of Molecular Sciences	MDPI
2022/05/13 - 2022/05/13	Plants (MDPI)	MDPI
2021/09/14 - 2021/09/14	Journal of Alzheimer’s Disease	IOS Press
2021/04/07 - 2021/07/20	International Journal of Molecular Sciences	Published by MDPI
2021/01/14 - 2021/01/14	Peer J - Life & Environment	PeerJ Journals
2018/06/06 - 2019/03/13	Neurochemical Research	Springer
2018/03/13 - 2018/03/13	OncoTargets and Therapy	DovePress
2018/02/18 - 2018/02/18	Neurobiology of Aging	Elsevier
2017/08/02 - 2017/11/09	British Journal of Pharmacology	Wiley Online Library
2015/03/30 - 2015/03/30	Brain Research	Elsevier
2012/07/20 - 2012/07/20	Neuropathology and Applied Neurobiology	Wiley Online Library

Committee member

	Activity description Role	Institution / Organization
2009 - 2019	Member of the Academic Title Equivalence Committee, Faculty of Pharmacy, University of Coimbra Member	Universidade de Coimbra Faculdade de Farmácia, Portugal
2006 - 2009	Member of the Scientific Committee, Faculty of Pharmacy, University of Coimbra Member	Universidade de Coimbra Faculdade de Farmácia, Portugal
2005 - 2006	Secretary of the Scientific Committee of the Faculty of Pharmacy, University of Coimbra
1998 - 2003	Member of the Scientific Committee, Faculty of Pharmacy, University of Coimbra Member	Universidade de Coimbra Faculdade de Farmácia, Portugal
1996 - 1998	Member of the Pedagogic Council, Faculty of Pharmacy, University of Coimbra Member	Universidade de Coimbra Faculdade de Farmácia, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020 - Current	Cell Biology (theoretical and lab classes)	Mestrado INtegrado em Ciências Farmacêuticas	Universidade de Coimbra Faculdade de Farmácia, Portugal
2020 - Current	Cell Biology (theoretical and lab classes)	Licenciatura em Ciências Bioanalíticas (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - Current	Biochemistry II (theoretical classes)	Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - Current	Metabolism (theoretical classes)	Licenciatura em Ciências Bioanalíticas	Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - Current	Complementary Immunology (theoretical classes)	Master's Course in Clinical Analysis (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - Current	lab classes of the curricular unit Metabolism	Bioanalytical Sciences degree (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - Current	Hematology and Immunology (theoretical and practical classes)	Integrated Master in Pharmaceutical Sciences and Bioanalytical Sciences degree (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - Current	Hematology and Immunology (theoretical and practical classes)	Licenciatura em Ciências Bioanalíticas (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal
1994 - Current	Lab classes of Biochemistry II	Mestrado Integrado em Ciências Farmacêuticas	Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2021	Analytical Biochemistry ( (theoretical and lab classes)	Bioanalytical Sciences degree (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - 2021	lab classes of the curricular unit Biochemistry	Bioanalytical Sciences degree and Biomedical Pharmacy degrees (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal
1994 - 2021	lab classes of Biochemistry I	Integrated Master in Pharmaceutical Sciences (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2018	Neurobiology and Disease (theoretical classes)	Integrated Master in Pharmaceutical Sciences (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2008 - 2017	Pathophysiology (theoretical classes)	Master's Course in Clinical Analysis (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2013	Molecular Biology (theoretical and practical classes)	Integrated Master in Pharmaceutical Sciences and Bioanalytical Sciences degre (Mestrado integrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2011	Laboratorial Methodologies (theoretical and lab classes)	Bioanalytical Sciences degree (Licenciatura)	Universidade de Coimbra Faculdade de Farmácia, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2020/05/19 - 2020/06/05	Member of the evaluation panel of R&D projects, Fundação para a Ciência e a Tecnologia (FCT): Research 4 COVID-19, 2nd Edition May 2020 Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia

Journal scientific committee

	Journal title (ISSN)	Publisher
2021/01/01 - 2021/12/31	Journal of Alzheimer’s Disease	IOS Press

Distinctions

Award

1992	Prémio “Professor Doutor António Pinho de Brojo” - Award for best academic achievement. Associação dos Antigos Estudantes de Coimbra em Lisboa, Portugal
1992	"Prémio Sociedade Farmacêutica Lusitana", - Award for best academic achievement. Portuguese Pharmaceutical Society, Portugal Ordem dos Farmacêuticos de Coimbra, Portugal

Other distinction

2017	Bolsa de Investigação Edgar Cruz e Silva Grupo de Estudos de Envelhecimento Cerebral e Demências com o patrocínio da Santa Casa da Misericórdia de Lisboa, Portugal