Henrique José Silva Santos (8417-3BB8-5036)

Curriculum Vitae

Henrique José Silva Santos

Henrique Santos is currently a graduate researcher at the Center for Neuroscience and Cell Biology of the University of Coimbra (CNC-UC). He graduated in Biology with a minor in Biochemistry from the University of Coimbra in 2021 and obtained a Master's degree in Cellular and Molecular Biology with a specialization in Neurobiology in 2023 from the same institution where he studied the role of SHANK3, an Autism Spectrum Disorder candidate gene, in cellular and 3D models derived from induced pluripotent stem cells (iPSC) with a particular emphasis in neurodevelopment.

Identification

Personal identification

Full name: Henrique José Silva Santos

Citation names

Santos, Henrique

Author identifiers

Ciência ID: 8417-3BB8-5036
ORCID iD: 0009-0006-7108-125X

Email addresses

hsantos@cnc.uc.pt (Professional)

Websites

cnc.uc.pt/pt/people/h-santos (Scholar)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2024/10 - 2028 Ongoing	Doutoramento em Biociências (Doutoramento) Major in Especialização em Neurociências Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/11 - 2024/07 Ongoing	Clinical Investigator Certificate Level 1 (Outros) Universidade Nova de Lisboa Medical School, Portugal Universidade de Aveiro, Portugal
2021 - 2023 Concluded	Mestrado em Biologia Celular e Molecular (Mestrado) Major in Especialização em Neurobiologia Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Departamento de Ciências da Vida, Portugal "THE HIDDEN PLAYER: NON-CANONICAL ROLE OF SHANK3 IN NEURODEVELOPMENT" (THESIS/DISSERTATION)	18
2018 - 2021 Concluded	Licenciatura em Biologia com Menor em Bioquímica (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal	16
2020/08 - 2020/09 Concluded	Cellular Mechanisms of Brain Function (Outros) edX LLC, United States École Polytechnique Fédérale de Lausanne Institut des neurosciences, Switzerland
2015 - 2015 Concluded	SPU30x: Super-Earths and Life (Outros) edX LLC, United States Harvard University, United States

Affiliation

Science

	Category Host institution	Employer
2023/11/28 - 2024/11/28	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09/01 - 2021/09/30	Research Trainee (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

	Category Host institution	Employer
2022/02 - 2022/03	Laboratory Rotation in Immunometabolism	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2021/11 - 2021/12	Laboratory Rotation in Neuronal Circuits and Behavior	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2021/06 - 2021/09	Laboratory Internship in the Gut-Brain Axis Laboratory	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2020/08 - 2021/01/31	Laboratory Project inserted in the Curricular Unit Project in Applied Biology under the theme "Human Brain Organoids in the Dissection of Neurodevelopmental Disorders"	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Projects

Grant

	Designation	Funders
2023/11/28 - Current	Astrocytes dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies NEURON/0002/2021 Research Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021 - 2021	Summer with Science: Research, Development and Interdisciplinary Innovation in the Physiolopathology of Aging and Lifestyle-dependent Diseases NA Scientific Initiation Fellow Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference poster

Santos, Henrique; Guedes, J. R.; Cardoso, Ana; Boeckers, Tobias; Peça, João. "The Hidden Player: Decoding the Non-canonical Role of SHANK3 in Neurodevelopment". Paper presented in Phelan-McDermid Syndrome Foundation International Conference, 2024.
Santos, Henrique; Guedes, J. R.; Cardoso, Ana; Boeckers, Tobias; Peça, João. "Beyond the Synapse: Exploring the Non-Canonical Role of SHANK3 in Neurodevelopment". Paper presented in ERANET NEURON Midterm Symposium - Berlin, 2024.
Santos, Henrique; Matos, Isabel. "Fora da Casca - Cultura ex-ovo de embriões de galinha". Paper presented in 25º Concurso de Jovens Cientistas, 2017.

Journal article

Oliveira, Ana Rafaela; Santos, Henrique; Martins, Solange; Seabra, Catarina; Cardoso, Ana; Peça, João. "Cellular and electrophysiological landmarks in organoids for neurodevelopmental research: pitfalls and opportunities". Frontiers (2024):
Under revision

Activities

Event organisation

	Event name Type of event (Role)	Institution / Organization
2021 - 2021	Organização do XXIII Encontro Nacional de Estudantes de Biologia (2021/03/27 - 2021/03/31) Meeting (Other)	Associação Nacional de Estudantes de Biologia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/11 - 2021/11	V Symposium of the Portuguese Glial Network Symposium	V Symposium of the Portuguese Glial Network Universidade de Coimbra, Portugal
2021/04 - 2021/04	XII Symposium on Bioengineering Symposium	XII Symposium on Bioengineering Universidade do Porto Faculdade de Engenharia, Portugal
2017/06 - 2017/06	Participação no 25º Concurso de Jovens Cientistas Call	25º Concurso de Jovens Cientistas

Association member

	Society Organization name	Role
2020/06 - 2021/09	Associação Nacional de Estudantes de Biologia	Vice-Presidente da Direção
2020/06 - 2021/06	Núcleo de Estudantes de Biologia da Associação Académica de Coimbra	Vice-Presidente da Mesa do Plenário
2019/06 - 2020/06	Associação Nacional de Estudantes de Biologia	Secretário da Mesa da Assembleia Geral da Associação Nacional de Estudantes de Biologia

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024/02/05 - 2024/02/09	Growth and Analysis of Human Brain Organoids - Neuronal Circuits and Behavior - PDBEB Courses 2023/2024	Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Mentoring / Tutoring

	Topic	Student name
2024/01 - 2024/06	Characterization of Neural Progenitors Derived from iPSCs in Phelan-McDermid Syndrome	João Afonso Silva
2024/03/01 - 2024/04/01	iPSC-derived Cortical Organoids as a platform for disease modeling	Fábio Lisboa
2024/01/27 - 2024/02/27	iPSC-derived Cortical Organoids as a platform for disease modeling	Pedro Lobo

Distinctions

Award

2024	Best Poster Award - Midterm Symposium of JTC 2021: Neurodevelopmental Disorders ERA-Net Cofund scheme, Belgium
2024	Best Poster Award - Phelan-McDermid Syndrome Foundation International Conference Phelan-McDermid Foundation, United States
2023	Merit Board of the Top 5% students, in the academic year 2022/2023 Universidade de Coimbra, Portugal