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Eva Gil Martins is a PhD student in the Doctoral program in Pharmaceutical Sciences specialization in Toxicology in the Faculty of Pharmacy of the University of Porto, developing her PhD project titled 'Phenethylamine derivatives: new insights on their pharmacological and toxicological profile'. She graduated in Biology from the Faculty of Sciences of the University of Porto in 2016. In 2018, she completed the master's degree in Analytical, Clinical and Forensic Toxicology from the Faculty of Pharmacy of the University of Porto. Her areas of interest include toxicology and forensic sciences, with particular emphasis on pharmaco(toxico)kinetics and pharmaco(toxico)dynamics.
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Identification

Personal identification

Full name
Eva Gil Martins

Citation names

  • Gil-Martins, E.
  • Martins, E.

Author identifiers

Ciência ID
841F-73D5-CB33
ORCID iD
0000-0002-8142-562X
Researcher Id
C-2084-2019
Scopus Author Id
36129701000

Email addresses

  • evagilmartins18@gmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2019/12/02 - 2023/12/02
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/09/10 - 2018/11/19
Concluded
 Toxicologia Analítica, Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Screening of newly synthetized xanthonic derivatives as potential P-glycoprotein inducers/activators: an innovative strategy to fight Alzheimer’s disease" (THESIS/DISSERTATION)
 18/20
2012/09/10 - 2016/07/05
Concluded
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Study of P-glycoprotein induction/activation by newly synthetized xanthones with potential therapeutic application" (THESIS/DISSERTATION)
 13/20
Affiliation

Science

Category
Host institution 		Employer
2019/12/01 - Current Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2019/02/15 - 2019/05/31 Researcher (Research) Universidade do Porto Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/02/15 - 2019/05/31 Sustainable Advanced Materials (SAM)
Norte-01-0145-FEDER-000028
Research Fellow
Universidade do Porto Centro de Investigação em Química, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
Outputs

Publications

Conference abstract
  1. Gil-Martins, E.; Martins, D.; Silva, V.; Fernandes, C.; Remião F.; Borges, F.; Silva, R.. "Mechanisms underlying new psychoactive phenethylamines cytotoxicity". 2021.
    Published • 10.1016/s0378-4274(21)00472-0
  2. Martins, M.; Maia, M.; Gil-Martins, E.; Gales, L.; Remião, F.; Pinto, M.; Silva, R.; Sousa, E.. "Towards the development of potential dual GSK-ß/BACE-1 inhibitors: a strategy to fight Alzheimer's disease". 2021.
    Published • 10.1016/s0378-4274(21)00507-5
  3. Fernandes, C.; Pinto, M.; Gil-Martins, E.; Silva, R.; Benfeito, S.; Mendes, R.; Paz, F.A.A.; Remião, F.; Borges, F.. "The nanomaterial toolkit for neurological disorders treatment". Paper presented in CIQUP II Workshop Meeting, Porto, 2020.
    Published
  4. Silva, V.; Silva, R.; Gil-Martins, E.; Sousa, E.; Resende, D.; Remião, F.; Rocha-Pereira, C.. "Xanthones as potential P-glycoprotein modulators at the intestinal barrier: in vitro and ex vivo studies". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsínquia, 2019.
    Published • 10.1016/j.toxlet.2019.09.002
  5. Gil-Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Remião, F.; Silva, R.. "P-glycoprotein modulation by xanthonic derivatives: a strategy to fight Alzheimer’s disease". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsínquia, 2019.
    Published • 10.1016/j.toxlet.2019.09.002
  6. Pinto, M.; Fernandes, C.; Gil-Martins, E.; Silva, R.; Benfeito, S.; Cagide, F.; Borges, F.; Remião, F.. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsínquia, 2019.
    Published
  7. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "Newly synthetized xanthonic derivatives as potential P-glycoprotein modulators: a strategy to fight Alzheimer’s disease". Paper presented in 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2019.
    Published
  8. Silva, V.; Silva, R.; Martins, E.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Rocha-Pereira, C.. "Newly synthetized xanthones as potential P-glycoprotein modulators at the intestinal barrier: in vitro and ex vivo studies". Paper presented in 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2019.
    Published
  9. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "In vitro modulation of P-glycoprotein by xanthonic derivates: implications on Alzheimer’s disease". Paper presented in SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2019.
    Published
  10. Silva, V.; Silva, R.; Martins, E.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Rocha-Pereira, C.. "Xanthones as potential P-glycoprotein modulators: in vitro and ex vivo studies". Paper presented in SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2019.
    Published
  11. Martins, E.; Palmeira, A.; Carmo, H.; Sousa, E.; Lemos, A.; Pinto, M.; Bastos, M.L.; Remião, F.; Silva, R.. "P-gp induction and activation as a potential therapeutic approach in intoxications and/or neurological diseases–in vitro and in silico studies". Paper presented in 54th Congress of the European Societies of Toxicology (EUROTOX 2018), Bruxelas, 2018.
    Published • 10.1016/j.toxlet.2018.07.032
  12. Lopes, A.; Martins, E.; Silva, R.; Fernandes, C.; Palmeira, A.; Remião, F.; Pinto, M.M.M.; Sousa, E.. "Small Chiral Molecules as potential P-gp Modulators: Synthesis and Studies of Enantioselectivity". Paper presented in 10ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2017.
    Published
  13. Martins, E.; Rodrigues, C.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; Carmo, H.; et al. "Screening of newly synthetized xanthonic derivatives as P-glycoprotein modulators - in silico and in vitro studies". Paper presented in 10ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2017.
    Published
  14. Martins, E.; Rodrigues, C.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; Carmo, H.; et al. "Identification of newly synthetized xanthonic derivates as potential P-glycoprotein modulators". Paper presented in SPF Meeting 2017 - Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2017.
    Published
  15. Martins, E.; Silva, R.; Palmeira, A.; Sousa, E.; Carmo, H.; Pinto, M.; Bastos, M.L.; et al. "Hit optimization of newly synthetized xanthonic derivatives as P-gycoprotein modulators – In silico and in vitro studies". Paper presented in 52nd Congress of the European Societies of Toxicology (EUROTOX 2016), Sevilha, 2016.
    Published • 10.1016/j.toxlet.2016.06.1709
Conference paper
  1. Lopes, A.; Martins, E.; Silva, R.; Fernandes, C.; Palmeira, A.; Remião, F.; Pinto, M.; Sousa, E.. "Studying the influence of stereochemistry in P-gp modulation: case-study with thioxantones". Paper presented in 2nd International Electronic Conference on Medicinal Chemistry, 2016.
    Published • 10.3390/ecmc-2-a014
Conference poster
  1. Gil-Martins, E.; Martins, D.; Silva, V.; Fernandes, C.; Remião, F.; Borges, F.; Silva, R.. "Mechanisms underlying new psychoactive phenethylamines cytotoxicity.". Paper presented in 56th Congress of European Societies of Toxicology (EUROTOX 2021), 2021.
  2. Martins, D.; Gil-Martins, E.; Fernandes, C.; Silva, R.; Borges, F.. "New insights on the mechanisms underlying the cytotoxicity of psychoactive NBOMe derivatives.". Paper presented in The College on Problems of Drug Dependence (CPDD) 83rd Annual Scientific Virtual Meeting, 2021.
  3. Chavarria, D.; Fernandes, C.; Silva, V.; Gil-Martins, E.; Remião, F.; Oliveira, P.J.; Borges, F.. "Design and development of piperine derivatives acting as potent MAO-B inhibitors and mild P-gp inhibitors". Paper presented in 4th WG meeting - MuTaLig COST ACTION CA1513 (Izmir, Turkey), 2020.
  4. Martins, D.; Silva, T.; Fernandes, C.; Soares, P.; Silva, C.; Silva, R.; Gil-Martins, E.; Borges, F.. "Toxicological profile of phenethylamine-based psychoactive drugs". Paper presented in European Medicinal Chemistry joint meeting (Catanzaro, Italy), 2019.
  5. Cruz, B.A.; Gil-Martins, E.; Silva, R.; Remião, F.. "Polimorfismos da Glicoproteína-P: Implicações Clínicas e Forenses". Paper presented in XIII Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde and In IV Congresso da Associação Portuguesa de Ciências Forenses (Porto, Portugal), 2019.
  6. Monjane, S.; Santos-Silva, V.; Gil-Martins, E.; Chavarria, D.; Borges, F.; Silva, R.; Fernandes, C.. "Descoberta de novas entidades químicas como potenciais moduladores de Glicoproteína-P". Paper presented in XIII Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde and In IV Congresso da Associação Portuguesa de Ciências Forenses (Porto, Portugal), 2019.
  7. Vaz, S.; Silva, R.; Amaral, M.H.; Martins, E.; Sousa Lobo, J.M.; Silva, A.C.. "Biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations". Paper presented in 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP) (Porto, Portugal), 2019.
  8. Silva, V.; Silva, R.; Gil-Martins, E.; Sousa, E.; Resende, D.; Pinto, M.; Bastos, M.L.; Remião, F.; Rocha-Pereira, C.. "Screening of newly synthetized xanthones and potential P-glycoprotein modulation at intestinal barrier- in vitro and ex vivo studies". Paper presented in Innovation in Pharmacy: Advances and Perspectives (Salamanca, Spain), 2018.
  9. Martins, E.; Palmeira, A.; Sousa, E.; Resende, D.; Puthongking, P.; Carmo, H.; Pinto, M.; et al. "Newly synthetized xanthonic derivatives as P-glycoprotein Modulators - in silico and in vitro studies.". Paper presented in Innovation in Pharmacy: Advances and Perspectives (Salamanca, Spain), 2018.
  10. Martins, E.; Palmeira, A.; Carmo, H.; Sousa, E.; Lemos, A.; Pinto, M.; Bastos, M.L.; Remião, F.; Silva, R.. "P-gp induction and activation as a potential therapeutic action in cases of intoxication and/or neurological diseases". Paper presented in 54th Congress of European Societies of Toxicology (EUROTOX 2018, Brussels, Belgium), 2018.
  11. Martins, E.; Palmeira, A.; Sousa, E.; Lemos, A.; Carmo, H.; Pinto, M.; Bastos, M.L.; Remião, F.; Silva, R.. "P-gp induction and activation by newly synthesized xanthonic derivatives as a potential therapeutic approach in intoxications and neurological diseases". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChem18Sicily, Palermo, Italy), 2018.
  12. Pisoeiro, C.; Gil-Martins, E.; Ferreira, M.U.J.; Remião, F.; Silva, R.. "Newly synthetized derivatives as P-glycoprotein modulators". Paper presented in XII Jornadas Científicas do Departamento de Ciências do Instituto Universitário de Ciências da Saúde e III Congresso da Associação Portuguesa de Ciências Forenses (Porto, Portugal), 2018.
  13. Pinto, M.; Fernandes, C.; Reis, J.; Martins, E.; Silva, R.; Lúcio, M.; Remião, F.; Garrido, J.; Borges, F.. "Enhancing the bioavailability properties of a potent monoamine oxidase-B inhibitor using a nanotechnological approach". Paper presented in 2nd WG meeting of the MuTaLig COST Action CA15135 (Tenerife, Spain), 2018.
  14. Silva, A.C.; Amaral, M.H.; Eiras, F.; Cunha, S.; Silva, R.; Martins, E.; Sousa Lobo, J.M.. "Biocompatibility of cutaneous formulations containing lipid nanoparticles". Paper presented in 6th FIP Pharmaceutical Sciences World Congress (Stockholm, Sweden), 2017.
  15. Lopes, A.; Martins, E.; Silva, R.; Fernandes, C.; Palmeira, A.; Remião, F.; Pinto, M.; Sousa, E.. "Importance of stereochemistry and P-gp modulation in drug development: in vitro studies with chiral thioxanthones". Paper presented in XIX National Congress of Biochemistry (Guimarães, Portugal), 2016.
  16. Silva, R.; Martins, E.; Palmeira, A.; Sousa, E.; Carmo, H.; Pinto, M.; Bastos, M.L.; et al. "Hit optimization of newly synthetized xanthonic derivatives as P-glycoprotein modulators - In silico and in vitro studies". Paper presented in 52nd Congress of European Societies of Toxicology (EUROTOX 2016, Seville, Spain), 2016.
  17. Silva, R.; Palmeira, A.; Carmo, H.; Martins, E.; Brito, T.; Lemos, A.; Puthongking, P.; et al. "Studies with (thio)xanthones as activators of P-glycoprotein to prevent cytotoxicity induced by xenobiotics". Paper presented in EFMC-ISMC 2016, XXIV EFMC International Symposium on Medicinal Chemistry (Manchester, UK), 2016.
  18. Rito, T.; Martins, E.; Rodrigues, C.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; et al. "Study of the cytotoxicity and potential P-gp modulation of newly synthetized xanthones with therapeutic potential". Paper presented in Encontro Anual do Departamento de Ciências Biológicas (Porto, Portugal), 2016.
  19. Martins, E.; Rodrigues, C.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; Carmo, H.; et al. "P-glycoprotein induction/activation by newly synthetized xanthones with potential therapeutic application". Paper presented in Encontro Anual do Departamento de Ciências Biológicas (Porto, Portugal), 2016.
  20. Martins, E.; Rodrigues, C.; Rito, T.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; et al. "P-glycoprotein induction/activation by newly synthetized xanthones with potential therapeutic application". Paper presented in Biologia na Parede (Porto, Portugal), 2016.
  21. Martins, E.; Rodrigues, C.; Silva, R.; Palmeira, A.; Sousa, E.; Lemos, A.; Puthongking, P.; et al. "P-glycoprotein induction/activation by newly synthetized xanthones with potential therapeutic application". Paper presented in Encontro CIÊNCIA’16 (Lisbon, Portugal), 2016.
Journal article
  1. Pina Costa, Cláudia; Nižic Nodilo, Laura; Silva, Renata; Gil-Martins, E.; Zadravec, Dijana; Kalogjera, Livije; Nuno Moreira, João; et al. "In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery: development, characterization and deposition studies in a 3D-printed human nasal cavity model". International Journal of Pharmaceutics 644 (2023): 123345. http://dx.doi.org/10.1016/j.ijpharm.2023.123345.
    10.1016/j.ijpharm.2023.123345
  2. Daniel Martins; Eva Gil-Martins; Fernando Cagide; Catarina da Fonseca; Sofia Benfeito; Carlos Fernandes; Daniel Chavarria; et al. "Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues". Pharmaceuticals (2023): https://doi.org/10.3390/ph16081158.
    10.3390/ph16081158
  3. Joana Torres; José Miguel Pereira; Rita Marques-Oliveira; Inês Costa; Eva Gil-Martins; Renata Silva; Fernando Remião; et al. "An In Vitro Evaluation of the Potential Neuroprotective Effects of Intranasal Lipid Nanoparticles Containing Astaxanthin Obtained from Different Sources: Comparative Studies". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041035.
    10.3390/pharmaceutics15041035
  4. Dantas, Daniela; Ribeiro, Ana I.; Carvalho, Filipe; Gil-Martins, E.; Silva, Renata; Remião, Fernando; Zille, Andrea; et al. "Red-shifted and pH-responsive imidazole-based azo dyes with potent antimicrobial activity". Chemical Communications 59 19 (2023): 2791-2794. http://dx.doi.org/10.1039/d3cc00372h.
    10.1039/d3cc00372h
  5. Costa, C.P.; Cunha, S.; Moreira, J.N.; Silva, R.; Gil-Martins, E.; Silva, V.; Azevedo, L.; et al. "Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells". International Journal of Pharmaceutics 607 (2021): 120933. http://dx.doi.org/10.1016/j.ijpharm.2021.120933.
    10.1016/j.ijpharm.2021.120933
  6. Mesiti, F; Gaspar, A; Chavarria, D; Maruca, A; Rocca, R; Gil-Martins, E; Barreiro, S; et al. "Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?". Journal of Medicinal Chemistry 64 15 (2021): 11169-11182. http://dx.doi.org/10.1021/acs.jmedchem.1c00510.
    10.1021/acs.jmedchem.1c00510
  7. Silva, V; Gil-Martins, E; Silva, B; Rocha-Pereira, C; Sousa, ME; Remião, F; Silva, Renata. "Xanthones as P-glycoprotein modulators and their impact on drug bioavailability". Expert Opinion on Drug Metabolism & Toxicology 17 4 (2021): 441-482. http://dx.doi.org/10.1080/17425255.2021.1861247.
    10.1080/17425255.2021.1861247
  8. Silva, V.; Gil-Martins, E.; Rocha-Pereira, C.; Lemos, A.; Palmeira, A.; Puthongking, P.; Sousa, E.; et al. "Oxygenated xanthones as P-glycoprotein modulators at the intestinal barrier: in vitro and docking studies". Medicinal Chemistry Research 29 6 (2020): 1041-1057. http://dx.doi.org/10.1007/s00044-020-02544-1.
    Published • 10.1007/s00044-020-02544-1
  9. Gil-Martins, E.; Barbosa, D.J.; Silva, V.; Remião, F.; Silva, R.. "Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders". Pharmacology & Therapeutics (2020): 107554. http://dx.doi.org/10.1016/j.pharmthera.2020.107554.
    Published • 10.1016/j.pharmthera.2020.107554
  10. Chavarria, D.; Fernandes, C.; Silva, V.; Silva, C.; Martins, E.; Soares, P.; Silva, T.; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry (2020): 111770. http://dx.doi.org/10.1016/j.ejmech.2019.111770.
    Published • 10.1016/j.ejmech.2019.111770
  11. Pinto, M.; Fernandes, C.; Martins, E.; Silva, R.; Benfeito, S.; Cagide, F.; Mendes, R.F.; et al. "Boosting Drug Discovery for Parkinson’s: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles". Pharmaceutics 11 7 (2019): 331-331. https://doi.org/10.3390/pharmaceutics11070331.
    Published • 10.3390/pharmaceutics11070331
  12. Vaz, S.; Silva, R.; Martins, E.; Sousa Lobo, J.M.; Silva, A.C.. "Evaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: In vitro and human in vivo studies". Colloids and Surfaces B: Biointerfaces 179 (2019): 242-249. http://dx.doi.org/10.1016/j.colsurfb.2019.03.036.
    Published • 10.1016/j.colsurfb.2019.03.036
  13. Martins, E.; Silva, V.; Lemos, A.; Palmeira, A.; Puthongking, P.; Sousa, E.; Rocha-Pereira, C.; et al. "Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies". Molecules 24 4 (2019): 707. http://dx.doi.org/10.3390/molecules24040707.
    Published • 10.3390/molecules24040707
  14. Lopes, A.; Martins, E.; Silva, R.; Pinto, M.; Remião, F.; Sousa, E.; Fernandes, C.. "Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies". Molecules 23 3 (2018): 626. http://dx.doi.org/10.3390/molecules23030626.
    Published • 10.3390/molecules23030626
  15. Eiras, F.; Amaral, M.H.; Silva, R.; Martins, E.; Sousa Lobo, J.M.; Silva, A.C.. "Characterization and biocompatibility evaluation of cutaneous formulations containing lipid nanoparticles". International Journal of Pharmaceutics 519 1-2 (2017): 373-380. https://doi.org/10.1016%2Fj.ijpharm.2017.01.045.
    Published • 10.1016/j.ijpharm.2017.01.045
Thesis / Dissertation
  1. Gil-Martins, E.. "Screening of newly synthetized xanthonic derivatives as potential P-glycoprotein inducers/activators: an innovative strategy to fight Alzheimer's disease". Master, Universidade do Porto Faculdade de Farmácia, 2018. https://hdl.handle.net/10216/117514.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/22 The nanomaterial toolkit for neurological disorders treatment. CIQUP II Workshop Meeting
Faculty of Sciences of the University of Porto (Porto, Portugal)
2019/02/15 Newly synthetized xanthonic derivatives as potential P-glycoprotein modulators: a strategy to fight Alzheimer’s disease 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP)
University of Porto (Porto, Portugal)
2019/02/15 Newly synthetized xanthones as potential P-glycoprotein modulators at the intestinal barrier: in vitro and ex vivo studies 12ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP)
University of Porto (Porto, Portugal)
2019/02/07 In vitro modulation of P-glycoprotein by xanthonic derivates: implications on Alzheimer’s disease SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (SPF) (Porto, Portugal)
2019/02/07 Xanthones as potential P-glycoprotein modulators: in vitro and ex vivo studies SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (SPF) (Porto, Portugal)
2017/02/10 Small Chiral Molecules as potential P-gp Modulators: Synthesis and Studies of Enantioselectivity 10ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP)
University of Porto (Porto, Portugal)
2017/02/09 Screening of newly synthetized xanthonic derivatives as P-glycoprotein modulators - in silico and in vitro studies 10ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP)
University of Porto (Porto, Portugal)
2017/02/02 Identification of newly synthetized xanthonic derivates as potential P-glycoprotein modulators SPF Meeting 2017 - Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (SPF) (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/06 - 2019/02/08 SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia. Forum for scientific discussion on experimental, pharmacological and toxicological research. (2019/02/06 - 2019/02/08)
Meeting
 Sociedade Portuguesa de Farmacologia, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/19 - 2023/06/24 Oemonom project intense learner meeting
Univerzita Karlova Farmaceutická Fakulta v Hradci Králové, Czech Republic
2023/04/27 - 2023/04/28 II TOXRUN Internacional Congress "No Boundaries for Toxicology: One Health, One Society, One Planet"
Meeting
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2022/07/14 - 2022/07/16 MedChem 2022 (XI Paul Ehrlich Meeting)
Meeting
Universitat Ramon Llull IQS School of Engineering, Spain
2022/05/04 - 2022/05/06 15ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Meeting
2022/04/07 - 2022/04/08 I Congresso Internacional da TOXRUN, V Congresso da Associação Portuguesa de Ciências Forenses
Meeting
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2021/09/27 - 2021/10/01 Toxicology Congress
Congress
 56th Congress of the European Societies of Toxicology (EUROTOX 2021)
EUROTOX, Belgium
2021/05/05 - 2021/05/07 14ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Universidade do Porto, Portugal
2020/07/01 - 2020/08/31 Online course on techniques for visualizing relationships in data, and systematic techniques for understanding the relationships using mathematics (ONLINE on Udacity by Dr. Sebastian Thrun). Intro to Statistics
2020/05/11 - 2020/07/16 Online course on becoming more effective writers, using practical examples and exercises. (ONLINE on Coursera by Dr. Kristin Sainani) Writing in the Sciences
Stanford University Department of Health Research and Policy, United States
2020/01/22 - 2020/03/05 Online course on the essentials of research data management (MOOC).
Other
 O Essencial da Gestão de Dados de Investigação
2019/05/16 - 2019/05/16 Importance of studying plants in environmental conservation and in agriculture improvement (sustainable food production, horticulture, forestry and production of non-food goods).
Seminar
 O Fascínio das Plantas (The Fascination of Plants)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/02/13 - 2019/02/15 Meeting organized by the University of Porto where students share their research and discuss future projects.
Meeting
 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Universidade do Porto, Portugal
2019/02/06 - 2019/02/08 Forum for scientific discussion on experimental, pharmacological and toxicological research.
Meeting
 SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/10 - 2018/07/10 Meeting designed to present the main lines of research under development at the biochemistry, microbiology and toxicology laboratories of the Faculty of Farmacy of the University of Porto.
Meeting
 Encontro Anual do Departamento de Ciências Biológicas
Universidade do Porto Faculdade de Farmácia, Portugal
2017/04/02 - 2017/04/04 Forum for scientific discussion on experimental, pharmacological and toxicological research.
Meeting
 SPF Meeting 2017 - Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia, Portugal

Fundação Bissaya Barreto, Portugal
2017/02/08 - 2017/02/10 Meeting organized by the University of Porto where students share their research and discuss future projects.
Meeting
 10ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Universidade do Porto, Portugal
2016/07/19 - 2016/07/19 Meeting designed to present the main lines of research under development at the biochemistry, microbiology and toxicology laboratories of the Faculty of Farmacy of the University of Porto.
Meeting
 Encontro Anual do Departamento de Ciências Biológicas
Universidade do Porto Faculdade de Farmácia, Portugal
2016/06/01 - 2016/06/01 Lecture about ethics in clinical research, with particular emphasis on clinical trials.
Other
 Ética em Investigação Clínica - Ensaios Clínicos
Universidade do Porto Faculdade de Farmácia, Portugal
2016/02/17 - 2016/02/19 Meeting organized by the University of Porto where students share their research and discuss future projects.
Meeting
 9ª Edição do Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Universidade do Porto, Portugal
2015/10/07 - 2015/12/02 Course to increase knowledge about the universe of forensic sciences and legal medicine.
Other
 XV Edição do Curso de Medicina Legal e Outras Ciências Forenses
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/03/24 - 2015/04/30 Course with lectures in various areas of forensic sciences, inclucing toxicology, genetics, chemistry, informatics, among others.
Other
 Curso de Ciências Forenses
Universidade do Porto Faculdade de Ciências, Portugal
2014/05/14 - 2014/05/14 Lecture about forensic sciences.
Other
 Ciências Forenses
Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/09/18 Discovery of new chemical entities as potential modulators of P-glycoprotein
(Thesis) Arguer
 Sandra António Monjane (Other)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10/19 - 2021/10/22 Novel challenges in Toxicology Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/13 - 2021/07/15 Bioanalytical Methods for Neurochemical Research Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/03/18 - 2021/03/20 Models of the Blood-Brain Barrier: Scientific Tools to Target the Brain Universidade de Lisboa Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2021/01/04 - 2021/09/10 New Psychoactive Phenethylamine Derivatives: Elucidation of Their Toxicological Profiles Catarina Teixeira da Fonseca
Distinctions

Award

2023 Best poster communication