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Marisa Freitas (MF) completed her PhD degree in Pharmaceutical Sciences in 2010, in Faculty of Pharmacy of University of Porto. In 2012, MF was awarded with a post-Doc FCT fellowship and in 2016 she was hired Assistant Researcher from the project New Technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases (NORTE-01-0145-FEDER-000024). In April of 2019, MF was hired as Assistant Researcher in the project "Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles (POCI-01-0145-FEDER-029248). In 2020 MF won a grant in the Call for Individual Scientific Employment Stimulus from FCT (2020.04126.CEECIND). MF was hired as an Assistant Researcher (reference LA/P/0008/2020), becoming part of the permanent staff at REQUIMTE in 2021. Her high scientific competence is supported by the +100 papers and 36 abstracts published in international journals, (70% in Q1 journals), 9 book chapters, 55 oral communications (11 as invited speaker) and 140+ poster communications in national and international conferences. Her h-index is 40 (Scopus) and she has 21000+ citations. MF is at the moment responsible for the supervision of several students: 4 PhD and 1 Master and completed the supervision of 6 Msc, 17 academic stages and 4 students on a mobility program being also collaborator in several national and international supervisions (26) from Brazil, Uruguay, Czech Republic, and Spain. Currently, MF was Principal Investigator of one funded project (POCI-01-0145-FEDER-029248) and participated in 20 projects funded by national and international funds. Moreover, MF enjoys international recognition evidenced by being: researcher of three COST actions [CA15129, CA16119, CA20121], External Advisor in the Global Burden of Disease Studies Study, peer-reviewer for +20 journals (Publons- Web of Science ResearcherIDAAY-7427-2020), Editorial Board Member in 4 journals (Molecules, Cells, Oxid Med Cell Longev, Braz J Pharm Sci). Furthermore, MF carries out educational activities through invited lectures at graduation and post-graduation courses. MF has been invited as member of several graduation juries all in viva voce oral exam, as jury in public tenders, and also as scientific evaluator in national and international meetings.
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Identification

Personal identification

Full name
Marisa Andreia Carvalho de Freitas

Citation names

  • Freitas, Marisa

Author identifiers

Ciência ID
8519-4598-A173
ORCID iD
0000-0001-9114-9967

Email addresses

  • marysa.freitas@gmail.com (Professional)

Addresses

  • Rua Jorge de Viterbo Ferreira 228, 4050-313, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Natural sciences - Other Natural Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2007/01/01 - 2010/12/15
Concluded
 Pharmaceutical Sciences (Doutoramento)
Major in Pharmaceutical and Medicinal Chemistry
Universidade do Porto Faculdade de Farmácia, Portugal
"The effect of metals on human neutrophils" (THESIS/DISSERTATION)
 Approved unanimously with distinction
2005 - 2006/11/17
Concluded
 Analytical Chemistry (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Estudo da activação de neutrófilos humanos pelo nitrato de níquel" (THESIS/DISSERTATION)
 Maximum
2000/08/15 - 2005/10/12
Concluded
 Agricultural Sciences Engineering (Licenciatura)
Major in Animal Nutrition
Universidade do Porto Faculdade de Ciências, Portugal
"A cor como método de avaliação do valor nutritivo do Corn Gluten Feed" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/03/01 - Current Contracted Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2016/07/01 - 2019/02/28 Contracted Researcher (Research) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2012/01/01 - 2016/06/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2020/01 - Current Use of polyphenols in the prophylaxis of silver nanoparticles induced-intestinal pro-inflammatory effects
SFRH/BD/150656/2020
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
 Sociedade Portuguesa de Química
Ongoing
2019/03 - Current Flavonoids loaded in nanocarriers as an approach to increase their bioefficacy against Diabetes mellitus
PD/BD/145169/2019
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/09 - 2027/09 Exploring the Effects of Parabens on Key Metabolic Pathways in Diabesity, in Co-Culture Systems Representing the Liver-Adipose-Inflammation Network
UI/BD/00361/2023
Supervisor
Fundação para a Ciência e a Tecnologia, Portugal
2021/01 - 2025/01 Phosphoglycoglycerol from Nature as model to new putative therapeutic agents
UI/BD/151271/2021
Supervisor
Fundação para a Ciência e a Tecnologia, Portugal
2012/01/01 - 2016/06/30 Study of anti-inflammatory properties of novel polyhydroxy-flavonoids and xanthone derivatives
SFRH/BPD /76909/2011
Post-doc Fellow
REQUIMTE, Universidade do Porto, Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2010/12/15 Papel dos metais pesados na activação de neutrófilos humanos. Implicação na libertação de factores pró-inflamatórios e na produção de espécies reactivas de oxigénio e de azoto
SFRH/BD/28502/2006
PhD Student Fellow
REQUIMTE, Universidade do Porto, Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/09/01 - Current Development of products for slowing skin aging based on on the synergistic action of resveratrol and extremolites
Obrazac NP1.1
Researcher
Farmaceutski fakultet Univerziteta u Sarajevu, Bosnia and Herzegovina
2021/01/01 - 2025/12/31 Associated Laboratory for Green Chemistry - Clean Technologies and Processes
LA/P/0008/2020
10.54499/LA/P/0008/2020
UID/QUI/50006/2019
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Aveiro, Portugal

Universidade de Évora, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/04 - 2023/09 Screening and pharmacological characterization of flavonoids as lead compounds for obesity treatment
EXPL/MED-QUI/0815/2021
 Fundação para a Ciência e a Tecnologia
2019/12 - 2022/11 Development of new inhibitors of invasive osteosarcoma based on fisetin derivatives
PTDC/MED-QUI/29243/2017
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06 - 2022/02 Interdisciplinary in silico, organic synthesis, in vitro, and in vivo studies towards new antidiabetic flavonoid scaffolds
PTDC/MED-QUI/29241/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018/06 - 2022/02 2-Styrylchromones in the treatment of rheumatoid arthritis: a promising therapeutic alternative
PTDC/MED-QUI/29253/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018/06 - 2021/12 Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles (205.094,57 €)
POCI-01-0145-FEDER-029248
Principal investigator
Fundação para a Ciência e a Tecnologia
2018 - 2020 Efeito da suplementação com curcuma longa (extrato) sobre marcadores inflamatórios e de estresse oxidativo e de glicoxidação em pacientes com doença inflamatória intestinal atendidos em um hospital escola de Alagoas
60030-000876/2016
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
 Fundação de Amparo à Pesquisa de Alagoas, Brasil
Concluded
2016/06 - 2019/12 Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?
PTDC/DTP-FTO/1489/2014
 Fundação para a Ciência e a Tecnologia
2016/06 - 2019/12 Carotenoid oxidation by reactive oxygen and nitrogen species: chemical analysis and biological activity
PTDC/QEQ-QAN/1742/2014
Researcher
Fundação para a Ciência e a Tecnologia
2016/04 - 2019/03 New technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases
NORTE-01-0145-FEDER-000024
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte

Autoridade de Gestão do Programa Operacional Regional do Norte
Concluded
2016 - 2018 Procesos multietapa para el aprovechamiento integral de macroalgas y biomasa vegetal
CTM2015-68503-R
Researcher
Ministerio de Economía y Competitividad
2013/01/01 - 2015/06/30 Chelators for novel therapeutic strategies
NORTE-07-0124-FEDER-000066
Researcher
REQUIMTE, Portugal
 Autoridade de Gestão do Programa Operacional Regional do Norte
Concluded
2013 - 2015 Extracción y purificación de compuestos bioactivos de Sargassum muticum
CTM2012-38095
Researcher
Universidade de Vigo, Spain
 Ministerio de Economía y Competitividad
Concluded
2010 - 2012 Proceso para el aprovechamiento de algas invasoras: obtencion de ingredientes cosmeticos con acción antioxidante
CTM2009-12664
Researcher
Universidade de Vigo - Campus Ourense, Spain
 Ministerio de Economía y Competitividad
Concluded
2008 - 2011 Rational design, synthesis and screening of an indole library for novel antioxidant and anti-inflammatory drug candidates
PTDC/QUI/65187/2006
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2022/06/22 - Current COST Action CA20121- Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar)
CA20121
Researcher
Ongoing
2020/01/01 - 2023/12/31 Project from Research Unit Associated Laboratory for Green Chemistry
UID/QUI/50006/2019
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Ongoing
2020/01/01 - 2023/12/31 Project from Research Unit Associated Laboratory for Green Chemistry
LA/P/0008/2020
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Ongoing
2016/04/11 - 2020/04/10 COST Action CA15129 - Diagnosis, Monitoring and Prevention of Exposure-Related Noncommunicable Diseases (DiMoPEx)
CA15129
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2019 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
 Fundação para a Ciência e a Tecnologia
2015 - 2018 Project from Research Unit Associated Laboratory for Green Chemistry
UID/QUI/5006/2013
Researcher
Fundação para a Ciência e a Tecnologia
2015/01 - 2017/12 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2013
Researcher
Fundação para a Ciência e a Tecnologia
2015 - 2017 Project from Research Unit on Applied Molecular Biosciences
UID/MULTI/04378/2013
Researcher
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Proença, Carina; Freitas, Marisa; Rocha, Silvia; Ferreira de Oliveira, José Miguel P.; Carvalho, Félix; Eduarda Fernandes. "Unraveling the complex mechanisms involved in obesity pathophysiology as potential targets for environmental chemicals". 2024.
    Under revision
  2. Adelaide Sousa; Carvalho, Félix; Eduarda Fernandes; Freitas, Marisa. "Applications of Silver Nanoparticles in Daily Life". In Applications of Silver Nanoparticles. Nova Science Publishers, 2023.
    Accepted
  3. Rocha, Sonia; Corvo, M. Luisa; Eduarda Fernandes; Freitas, Marisa. "Novel Strategies for Managing Diabetes mellitus Using Lipid-Based Delivery Systems as Vehicles of Polyphenols". In Principles and Practices of Novel Drug Delivery Systems. 2023.
    Accepted
  4. Adelaide Sousa; Daniela Ribeiro; Eduarda das Graças Rodrigues Fernandes; Marisa Freitas. Corresponding author: Marisa Freitas. "Silver Nanoparticles: An Approach to Their Synthesis, Characterization and Biological Activities". In Advances in Nanotechnology, 31. United States: Nova Science Publishers, 2022.
    Published
  5. Freitas, Marisa; Ferreira de Oliveira, José Miguel Pimenta; Corvo, M. Luísa; Carvalho, Félix Dias; Fernandes, Eduarda; Ribeiro, Daniela. "Insights on the Potential Preventive and Healing Effects of Flavonoids in Inflammatory Bowel Disease". In Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer, edited by Ashok Kumar Pandurangan, 38-66. IGI Global, 2021.
    10.4018/978-1-7998-3580-6.ch003
  6. Ribeiro, Daniela; Freitas, Marisa; Ferreira de Oliveira, José Miguel P.; Corvo, M. Luisa; Carvalho, Félix Dias; Fernandes, Eduarda. "Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease". In Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer, 1-23. IGI Global, 2021.
    Published • 10.4018/978-1-7998-3580-6.ch001
  7. Lucas, Mariana; Freitas, Marisa; Carvalho, Félix; Fernandes, Eduarda; Ribeiro, Daniela. "Antioxidant and Pro-oxidant Activities of Carotenoids". In Reference Series in Phytochemistry, 1-27. Springer International Publishing, 2020.
    Published • 10.1007/978-3-030-45299-5_4-1
  8. Freitas, Marisa; Ribeiro, Daniela; Silva, Paula; Lima, Jose L. F. C.; Carvalho, Felix; Fernandes, Eduarda. "Pro-inflammatory and toxic effects of silver nanoparticles". In Nanoparticles in Life Sciences and Biomedicine, edited by Ana Rute Neves ; Salette Reis, 505-530. Pan Stanford, 2018.
    10.1201/9781351207355-17
  9. Ribeiro, Daniela; Fernandes, Eduarda; Freitas, Marisa. "Flavonoids as Modulators of Neutrophils' Oxidative Burst: Structure-Activity Relationship". In Polyphenols: Mechanisms of Action in Human Health and Disease, edited by Ronald Ross Watson; Victor R. Preedy ; Sherma Zibadi, 261-276. Elsevier, 2018.
    10.1016/b978-0-12-813006-3.00020-9
  10. Fernandes, Eduarda; Freitas, Marisa; Chisté, Renan C.; Falqué, Elena; Domínguez, Herminia. "Grape polyphenol-rich products with antioxidant and anti-inflammatory properties". In Oxidative Stress and Antioxidant Protection, edited by Donald Armstrong ; Robert D. Stratton, 389-402. John Wiley & Sons, Inc, 2016.
    10.1002/9781118832431.ch25
Conference abstract
  1. Carina S.P. Vieira; Freitas, Marisa; Eduarda Fernandes; Segundo, Marcela; Araujo, Alberto. "Modulation of cytochrome P450 pathways by flavonoids: unravelling the CYP3A4 inhibition in metabolism". Paper presented in XXVII Encontro Luso-Galego de Química, Porto, 2023.
  2. Adelaide Sousa; Ana T. Rufino; Ana Ramalho; Carvalho, Félix; Eduarda Fernandes; Freitas, Marisa; Ana Rufino; Marisa Freitas. "Silver nanoparticles induce an inflammatory response of intestinal C2BBe1 cells". Paper presented in SOT 62nd Annual Meeting and ToxExpo (Toxicological Sciences), 2023.
    Published
  3. Rocha, Sónia; Ribeiro, Daniela; Silva, Vera L. M.; Artur M. S. Silva; Corvo, M. Luísa; Eduarda Fernandes; Freitas, Marisa; et al. "New Insights on the inhibition of cyclooxygenases by 4-styrylpyrazoles: an enzymatic and human whole blood study". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, 2022.
    Published • 10.3390/chemproc2022011001
  4. Adelaide Sousa; Azevedo, Rui; Sara Oliveira; Inês Preguiça; Sofia Viana; Flávio Reis; Agostinho Almeida; et al. Corresponding author: Freitas, Marisa. "Biodistribution and cytokine production following oral administration of silver nanoparticles to C57BL/6J mice.". Paper presented in XVIth International Congress of Toxicology (Toxicology Letters), 2022.
    Published
  5. Mariana Lucas; Freitas, Marisa; Vera Silva; Artur M. S. Silva; Eduarda Fernandes; Daniela Ribeiro; Marco Zanchetta. "Cytotoxicity and anti-inflammatory potential of 2-styrylchromones". Paper presented in XVIth International Congress of Toxicology (Toxicology Letters), 2022.
    Published
  6. Mariana Lucas; Freitas, Marisa; Artur M. S. Silva; Eduarda Fernandes; Daniela Rbeiro. "Modulation of Human Neutrophils' Oxidative Burst by Hydroxylated 2-Styrylchromones". Paper presented in 1st International Electronic Conference on Biomedicine (Biology and Life Sciences Forum), 2021.
    Published
  7. Freitas, Marisa; Carina Proença; Sarraguça C. Mafalda; Daniela Ribeiro; Eduarda Fernandes. "Assessment of HOCl production in human blood experimental optimization and proof of concept for the antioxidant activity of flavonoids in this complex matrix". Paper presented in 27th Annual Conference of Society for Redox Biology and Medicine (Free Radical Biology and Medicine), 2020.
    Published
  8. Daniela Sofia Almeida Ribeiro; Marisa Freitas; Félix Carvalho; Eduarda das Graças Rodrigues Fernandes; Daniela Ribeiro; Eduarda Fernandes. "The extended effects of thapsigargin on human neutrophils calcium pathways". Paper presented in 58th Annual Meeting & Tox Expo, Baltimore, 2019.
    Published
  9. Diana Pinto; Ana F. Vinha; Freitas, Marisa; M. Beatriz P.P. Oliveira. "Adansonia digitata fruit: compounds and antioxidante activity against reactive species". Paper presented in Livro de Resumos XIV Encontro de Química dos Alimentos Indústria: Ciência, Formação e Inovação, Viana do castelo, 2018.
    Published
  10. Filipa B. Pimentel; Anabela S. G. Costa; Rita C. Alves; Marisa Freitas; Eduarda Fernandes; M. Beatriz P. P. Oliveira. "Translational Research and Innovation in Human and Health Science: Nutritional and antioxidant screening of Gracilaria vermiculophylla". Paper presented in 3rd International Congress of CiiEM (Annals of Medicine), Lisbon, 2018.
    Published
  11. Daniela Ribeiro; Tânia Soares; Sílvia Rocha; Mafalda Sarraguça; Eduarda Fernandes; Marisa Freitas. "Optimization of experimental settings for the assessment of HOCl in human blood, using the fluorescent probe APF". Paper presented in Society for Free Radical Research – International Biennial Meeting (Free Radical Biology and Medicine), Porto, 2018.
    Published
  12. Tânia Soares; Marisa Freitas; Félix Carvalho; Eduarda Fernandes. "Silver nanoparticles stimulate neutrophils’ oxidative burst through the activation of protein kinase C.". Paper presented in Society for Free Radical Research – International Biennial Meeting (Free Radical Biology and Medicine), Lisbon, 2018.
    Published
  13. Tânia Soares; M. Gónzalez-Gómez; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Polyethylemine coated silver nanoparticles induce human neutrophils’ oxidative burst via NADPH oxidase, through the activation of PKC". Paper presented in 54th Congress of the European Societies of Toxicology (Toxicology Letters), 2018.
    Published
  14. Tânia Soares; Freitas, Marisa; Carvalho, Félix; Eduarda Fernandes. "Low size citrate coated silver nanoparticles are potent inducers of human neutrophils’ oxidative burst". Paper presented in 54th Congress of the European Societies of Toxicology (Toxicology Letters), 2018.
    Published
  15. Daniela Ribeiro; Adelaide Sousa; Rocha, Silvia; Freitas, Marisa; Eduarda Fernandes. "Beta-Carotene and its biological oxidation products: are they good modulators of pro-oxidant reactive species in human blood and neutrophils assay systems?". Paper presented in Meeting of the International HNE-Club and the University of Graz - Reactive Oxygen Species and Lipid Peroxidation in Human Health and Disease (Free Radical Biology and Medicine), 2018.
    Published
  16. Marisa Freitas; Adelaide Sousa; Daniela Ribeiro; Eduarda Fernandes. "Prediction of anti-diabetic activity of flavonoids targeting alpha-glucosidase". Paper presented in 22nd International Conference on Prevention of Diabetes and Complications (Pancreatic Disorders and Therapy), London, 2017.
    Published
  17. Carina Proença; Daniela Ribeiro; Marisa Freitas; Joana L. C. Sousa; Artur M. S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "Structure-related inhibition of protein tyrosine phosphatase 1B (PTP1B) by flavonoids". Paper presented in 22nd International Conference on Prevention of Diabetes and Complications (Pancreatic Disorders and Therapy), London, 2017.
    Published
  18. Carina Proença; Marisa Freitas; Daniela Ribeiro; Joana L. C. Sousa; Artur M. S. Silva; Eduarda Fernandes. "The antioxidant activity of novel polyhydroxylated 3-hydroxy-2-stytrylchromones and 3-hydroxyflavones". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry (Pharmaceuticals), Porto, 2015.
    Published
  19. Daniela Ribeiro; Marisa Freitas; Sara M. Tomé; Artur M. S. Silva; Eduarda Fernandes. "Flavonoids’ effects in proinflammatory signaling systems: in vitro structure/activity studies". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry (Pharmaceuticals), Porto, 2015.
    Published
  20. Renan Campos Chisté; Diana Couto; Marisa Freitas; Vera Marisa Costa; Agostinho Almeida; M. Arturo Lopez Quintela; José Rivas; et al. "The putative pro-inflammatory effect and oxidative stress induced by polyacrylic acid-coated iron oxide nanoparticles in mice: a biodistribution and toxicological study". Paper presented in EUROTOX (Toxicology Letters), Porto, 2015.
    Published
  21. Paula Silva; Diana Couto; Marisa Freitas; Vera Marisa Costa; Renan Campos Chisté; M. Arturo Lopez Quintela; José Rivas; et al. "Distribution of polyacrylic acid-coated iron oxide nanoparticles in the liver and spleen of CD-1 mice and filtration by the respective mononuclear phagocyte system". Paper presented in EUROTOX (Toxicology Letters), Porto, 2015.
    Published
  22. Daniela Ribeiro; Larine Kupski; Eliane Badiale Furlong; Freitas, Marisa; Eduarda Fernandes. "Pro-inflammatory and toxic effects of ochratoxin and ochratoxin a in human neutrophils". Paper presented in 51st Congress of the European Societies of Toxicology (Toxicology Letters), 2015.
    Published
  23. Renan Campos Chisté; Alessandra Braga Ribeiro; Alessandra Berto; Marisa Freitas; Jesuí V. Visentainer; Eduarda Fernandes. "Vismia cauliflora extracts: bioactive compounds and the in vitro scavenging capacity against reactive oxygen and nitrogen species". Paper presented in Society for Free Radical Research - Europe Meeting (Free Radical Biology and Medicine), Paris, 2014.
    Published • 10.1016/J.FREERADBIOMED.2014.10.748
  24. Alessandra Braga Ribeiro; Alessandra Berto; Daniela Ribeiro; Marisa Freitas; Renan Campos Chisté; Jesuí V. Visentainer; Eduarda Fernandes. "Stem bark and flower extracts of Vismia cauliflora: modulation of oxidative burst in human neutrophils’ and inhibition of oxidative damage in human erythrocytes". Paper presented in Society for Free Radical Research - Europe Meeting (Free Radical Biology and Medicine), Paris, 2014.
    Published
  25. Freitas, Marisa; Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Eduarda Fernandes. "Anti-inflammatory and pro-apoptotic activities of chlorinated flavonoids in human neutrophils". Paper presented in Society of Free Radical Research: Free Radicals: Insights in signaling and adaptative homesostasis (Free Radical Biology and Medicine), 2014.
    Published
  26. Daniela Ribeiro; Freitas, Marisa; José Luís Fontes Costa Lima; Eduarda Fernandes. "Flavonoids inhibit the production of cytokines/chemokines and induce apoptosis in human neutrophils". Paper presented in Society of Free Radical Research: Free Radicals: Insights in signaling and adaptative homesostasis (Free Radical Biology and Medicine), 2014.
    Published
  27. Diana Couto; Irene Dias; Marisa Freitas; Graça Porto; M. Arturo Lopez Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes. "Polyacrylic acid coated and naked iron oxide nanoparticles: Their effects on neutrophils’ oxidative burst and inflammatory process". Paper presented in Society for Free Radical Research - Europe Meeting (Free Radical Biology and Medicine), Athens, 2013.
    Published
  28. Renan Campos Chisté; Marisa Freitas; Adriana Zerlotti Mercadante; Eduarda Fernandes. "Carotenoids inhibit peroxyl radical-induced oxidation of hemoglobin and lipids in human erythrocytes". Paper presented in Society for Free Radical Research - Europe Meeting (Free Radical Biology and Medicine), Athens, 2013.
    Published • 10.1016/J.FREERADBIOMED.2013.08.074
  29. Daniela Ribeiro; Marisa Freitas; Sara M. Tomé; Artur M. S. Silva; Graça Porto; Eduarda Fernandes; Eduarda Fernandes. "Flavonoids as modulators of human neutrophils’ oxidative burst.". Paper presented in 16th Biennial Meeting of the Society for Free Radical Research International (Free Radical Biology and Medicine), London, 2012.
    Published
  30. Renan Campos Chisté; Freitas, Marisa; Adriana Zerlotti Mercadante; Eduarda Fernandes; Marisa Freitas. "ß-Carotene and Zeaxanthin prevent peroxyl radical-induced hemolysis of human erythrocytes". Paper presented in SFRBM's 19th Annual Meeting (Free Radical Biology and Medicine), London, 2012.
    Published
  31. Diana Couto; Freitas, Marisa; M. Arturo Lopez-Quintela; José Rivas; Paulo Freitas; Carvalho, Félix; Eduarda Fernandes. "Iron oxide nanoparticles accelerate apoptotic death of human neutrophils". Paper presented in International Conference and Exhibition on Nanotechnology & Nanomedicine (Journal of Nanomedicine Nanotechnology), 2012.
    Published
  32. Diana Manuel Mocho de Bastos Couto; Marisa Freitas; Irene Dias; Eduarda das Graças Rodrigues Fernandes; Diana Couto; Eduarda Fernandes. "Modulação do burst oxidativo de neutrófilos humanos por derivados de 3-hidroxiflavona". Paper presented in IV Congresso Ibero-Americano de Ciências Farmacêuticas, Lisboa, 2011.
    Published
  33. Daniela Ribeiro; Diana Couto; Ana Gomes; Marisa Freitas; Eduarda Fernandes; José L. F. C. Lima. "Scavenging activity for hypochlorous acid and peroxyl radical by sulfasalazine and its metabolites, sulfapyridine and 5 -aminosalicylic acid". Paper presented in 1st National Meeting on Medicinal Chemistry (Revista Portuguesa de Farmácia), Porto, 2008.
    Published
  34. Freitas, Marisa; Marisa Freitas; Graça Porto; Eduarda Fernandes; José L. F. C. Lima; Marisa Freitas (Presenter). "Oxidative burst in neutrophils from hemochromatosis patients". Paper presented in Society for Free Radical Research-Europe 2007 Meeting (Free Radical Research), Vilamoura, 2007.
    Published
  35. Marisa Freitas; Eduarda Fernandes; José L. F. C. Lima; Marisa Freitas (Presenter). "Nickel nitrate stimulates human neutrophils oxidative burst in vitro.". Paper presented in 8th World Congress on Inflammation (Inflammation Research), Copenhagen, 2007.
    Published
Conference paper
  1. Ferreira de Oliveira, José Miguel P.; Proença, Carina; Rufino, Ana Teresa; Silva, Artur Manuel Soares; Fernandes, Eduarda; Santos, Raquel; Moreira, Beatriz; et al. Corresponding author: Ferreira de Oliveira, José Miguel P.. "P12-36 Cytotoxicity of chlorinated flavonoids in osteosarcoma in vitro models". Paper presented in XVIth International Congress of Toxicology (ICT2022), Maastricht, 2022.
    Published • 10.1016/j.toxlet.2022.07.515
  2. Santos, Clementina M.M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur; Fernandes, Eduarda. "Inhibition of pancreatic a-amylase activity by a group of hydroxyxanthones". 2020.
  3. Santos, Clementina M.M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur; Fernandes, Eduarda. "Synthesis and in vitro a-glucosidase inhibitory activity of polyhydroxylated 2-styrylchromones". 2019.
Conference poster
  1. Ana Ramalho; Carvalho, Félix; Eduarda Fernandes; Freitas, Marisa. "Unveiling the neutrophil response to parabens". Paper presented in XVII Encontro Luso-Galego de Química, 2023.
  2. Inês Santos; Adelaide Sousa; Carvalho, Félix; Eduarda Fernandes; Freitas, Marisa. "In vitro effects of silver nanoparticles and potential protective role of quercetin on the intestinal cell line C2BBe1". Paper presented in XVII Encontro Luso-Galego de Química, 2023.
  3. João Sousa Janela; Mariana Lucas; Freitas, Marisa; Dania Shriki; Carla Varela; Elisiário Tavares da Silva; Eduarda Fernandes; Fernanda Roleira. "Synthesis and COX-2 inhibition study of amides derived from 3,5-di-tert-butyl-4-hydroxycinnamic acid". Paper presented in Pharma Day-Faculdade de Farmácia da Universidade de Coimbra, 2023.
  4. Catarina M. Correia; Freitas, Marisa; Adelaide Sousa; Eduarda Fernandes; Artur M. S. Silva; Vera L. M. Silva. "(E)-2 Styrylchromones: Synthesis and evaluation of the inhibitory effects on the oxidative burst of human monocytes.". Paper presented in Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  5. Clementina M. M. Santos; Carina Proença; Freitas, Marisa; Alberto Nova Araújo; Artur M. S. Silva; Eduarda Fernandes. "Exploring the inhibitory potential of 2-styrylchromones on pancreatic a-amylase". Paper presented in Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  6. João Sousa Janela; Mariana Lucas; Freitas, Marisa; Dania Shriki; Carla Varela; Elisiário Tavares da Silva; Eduarda Fernandes; Fernanda Roleira. "Design, synthesis and structure-activity relationships of amides derived from 3,5-di-tert-butyl-4-hydroxycinnamic acid as COX-2 inhibitors". Paper presented in MedChem 2023- XII Meeting of Paul Ehrlich Euro-PhD Network, 2023.
  7. Lucas Pires; João Sousa Janela; Mariana Lucas; Marisa Freitas; Rosane N. Castro; Eduarda Fernandes; Fernanda M. F. Roleira; Elisiário J. Tavares. "Design, Synthesis and Study of the Structure-Activity Relationships of New O-Prenylated Amides from Caffeic Acid as COX-2 Inhibitors". Paper presented in MedChem 2023- XII Meeting of Paul Ehrlich Euro-PhD Network, 2023.
  8. Mariana Lucas; Freitas, Marisa; Daniela Ribeiro; Artur M.S. Silva; Eduarda Fernandes. "Exploring the potential of 2-styrylchromones as COX-2 inhibitors". Paper presented in 6th Symposium in Medicinal Chemistry, 2023.
  9. Adelaide Sousa; Rui Azevedo; Costa, Vera M; Sara Oliveira; Inês Preguiça; Sofia Viana; Flávio Reis; et al. "Impact of dietary exposure to silver nanoparticles on the intestinal inflammatory response in C57BL/6J mice". Paper presented in 12th International Symposium on Biological Monitoring in Occupational and Environmental Health, 2023.
  10. Sónia Rocha; Carina Proença; Artur M. S. Silva; Corvo, M. Luisa; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Targeting hepatic glucose and glycogen metabolism with chromone derivatives.". Paper presented in IDF World Diabetes Congress 2022, 2022.
  11. Carina Proença; Sónia Rocha; Freitas, Marisa; Artur M. S. Silva; Eduarda Fernandes. "The effect of flavonoids and pyrazoles in the emerging targets of type 2 diabetes mellitus, PTP1B and FBPase.". Paper presented in IDF World Diabetes Congress 2022, 2022.
  12. Lucas, Mariana; Freitas, Marisa; Silva, Artur M.S.; Fernandes, Eduarda; Ribeiro, Daniela. "2-Styrylchromones modulate prostaglandins production through the inhibition of COX-2". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
  13. Rocha, Silvia; Álvaro Tomé; Ana T. Rufino; Freitas, Marisa; Carvalho, Félix; Artur M. S. Silva; Eduarda Fernandes. "Chalcones as Potential Inhibitors of Pancreatic Lipase". Paper presented in The 8th International Electronic Conference on Medicinal Chemistry, 2022.
  14. José M. P Ferreira de Oliveira; Carina Proença; Raquel Santos; Beatriz Moreira; Ana T. Rufino; Freitas, Marisa; Daniela RIbeiro; et al. "Evaluation of cytotoxic potential of polyhydroxylated phenylchromones in human osteosarcoma in vitro models". Paper presented in XXII Congresso Brasileiro de Toxicologia- CBTox, 2022.
  15. Joana Correia; Beatriz Vicente; Sónia Rocha; Vera L.M. Silva; Pedro M.O. Gomes; Artur M.S. Silva; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Inhibition of enzyme a-glucosidase by styrylchromones and styrylpyrazoles". Paper presented in IJUP’15th Meeting of Young Researchers of University of Porto, 2022.
  16. Jorge Silva; Adelaide Sousa; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Flavonoids hinder human neutrophils’ oxidative burst induced by silver nanoparticles". Paper presented in IJUP’15th Meeting of Young Researchers of University of Porto, 2022.
  17. Ricardo Monteiro; Mariana Lucas; Freitas, Marisa; Eduarda Fernandes; Daniela Ribeiro. "2’,4-Dihydroxychalcone is a selective scavenger of hydrogen peroxide". Paper presented in IJUP’15th Meeting of Young Researchers of University of Porto, 2022.
  18. Maria Carolina Lobo; Sílvia Rocha; Freitas, Marisa; Carvalho, Félix; Artur M.S. Silva; Eduarda Fernandes; Ana T. Rufino. "In vitro inhibitory activity of polyphenols against pancreatic lipase and a-amylase". Paper presented in IJUP’15th Meeting of Young Researchers of University of Porto, 2022.
  19. Proença, Carina; Freitas, Marisa; Rufino A.; de Oliveira, José Miguel P. Ferreira; Silva, Artur M. S.; Fernandes, Pedro Alexandrino; Fernandes, Eduarda. "Dual inhibition of carbohydrate-hydrolysing enzymes a-amylase and a-glucosidase by flavonoids". Paper presented in 14.º Encontro Nacional de Química Orgânica (14ENQO) e 7.º Encontro Nacional de Química Terapêutica (7ENQT), 2022.
  20. Adelaide Sousa; Ana T. Rufino; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Health impact of silver nanoparticles: potential harmful effects in human monocytes". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  21. Carina Proença; Freitas, Marisa; Ana T. Rufino; José Miguel P. F. Oliveira; Artur M. S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "The possible role of flavonoids on postprandial hyperglycaemia through inhibition of carbohydrate-hydrolysing enzymes". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  22. Mariana Lucas; Freitas, Marisa; Artur M.S. Silva; Eduarda Fernandes; Daniela Ribeiro. "Evaluation of COX-2 inhibitory activity by hydroxylated and methoxylated 2-styrylchromones". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  23. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Styrylpyrazoles and chromone derivatives as glycogen phosphorylase inhibitors: a combined enzyme kinetic and molecular docking study". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  24. Ana T. Rufino; Ana Ramalho; Adelaide Sousa; José Miguel P. Ferreira de Oliveira; Paulo Freitas; Manuel A. Gonzalez Gómez; Yolanda Piñeiro-Redondo; et al. Corresponding author: Freitas, Marisa. "Evaluation of cytotoxic and pro-inflammatory effects of silver nanoparticles: Potential protective effect of flavonoids". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting., 2022.
  25. Maria Carolina Lobo; Sílvia Rocha; Ana T. Rufino; Freitas, Marisa; Artur M.S. Silva; Eduarada Fernandes. "Inhibition of pancreatic lipase and a-amylase by polyphenols in in vitro microanalysis systems". Paper presented in 14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting, 2022.
  26. Clementina M. M. Santos; Proença, Carina; Freitas, Marisa; Alberto N. Araújo; Artur M. S. Silva; Eduarda Fernandes; Carina Proença; et al. "Analysis of the antidiabetic potential of natural xanthones through inhibition of a-amylase and a-glucosidase activities". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  27. Larine Kupski; Gabriela Lemos Mendes; Daniela Ribeiro; Marisa Freitas; Eduarda Fernandes; Eliana Badiale-Furlong; Anelise Christ Ribeiro. "OTA degradation by carboxypeptidase A: a study of mechanism and applicability". Paper presented in 2021 ILSI Europe Early Career Scientists Seminar on Food Contaminants: mycotoxins research and mitigation strategies in Europe and Latin America, 2021.
  28. Raquel Santos; Beatriz Moreira; Ana T. Rufino; Carina Proença; Marisa Freitas; Eduarda Fernandes; José M. P Ferreira de Oliveira; et al. "Effect of phenolic compounds on the apoptotic process in human osteosarcoma cells". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  29. Mariana Lucas; Marisa Freitas; Joana L.C. Sousa; Artur M.S. Silva; Eduarda Fernandes; Daniela Ribeiro. "The impact of B-ring substituents on the styrylchromones’ ability to modulate the levels of reactive prooxidant species". Paper presented in The 7th International Electronic Conference on Medicinal Chemistry, 2021.
  30. Ricardo Monteiro; Mariana Lucas; Marisa Freitas; Catarina M. Correia; Vera L M Silva; Artur M. S. Silva; Eduarda Fernandes; Daniela Ribeiro. "Chalcones versus 2-styrylchromones: Which are the best oxygen and nitrogen reactive species scavengers?". Paper presented in The 7th International Electronic Conference on Medicinal Chemistry, 2021.
  31. Adelaide Sousa; Ana T. Rufino; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas. "Cytotoxic potential of silver nanoparticles to human neutrophils and human monocytes". Paper presented in SINFONIA- Safety in Nanomaterials and Nanotechnology, 2021.
  32. Sónia Rocha; Catarina M Correia; Vera L M Silva; Artur M Silva; M Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Polyphenols as potential modulators of type 2 diabetes mellitus through the inhibition of glycogen phosphorylase". Paper presented in 14th World Congress on Polyphenols Applications, 2021.
  33. Sónia Rocha; Mariana Lucas; Vera L. M. Silva; Artur M. S. Silva; Alberto Nova Araújo; Corvo, M. Luisa; Eduarda Fernandes; et al. "The effect of pyrazoles on the emerging diabetic therapeutic targets: Protein Tyrosine Phosphatase 1b and Glycogen Phosphorylase". Paper presented in Interfacing Chemical Biology and Drug Discovery - 56th International Conference on Medicinal Chemistry, 2021.
  34. Mariana Lucas; Marisa Freitas; Artur M.S. Silva; Eduarda Fernandes; Daniela Ribeiro. "The effects of methoxylated 2-styrylchromones on neutrophils’ viability and oxidative burst". Paper presented in Interfacing Chemical Biology and Drug Discovery - 56th International Conference on Medicinal Chemistry, 2021.
  35. Carina Proença; Ana T. Rufino; José Miguel P. Ferreira de Oliveira; Marisa Freitas; Pedro A. Fernandes; Artur M. S. Silva; Eduarda Fernandes. "Evaluation of the inhibitory activity of flavonoids on sucrase-isomaltase (a-glucosidase) in a caco-2/tc7 cellular model". Paper presented in Interfacing Chemical Biology and Drug Discovery - 56th International Conference on Medicinal Chemistry, 2021.
  36. Jorge Silva; Adelaide Sousa; Eduarda Fernandes; Marisa Freitas. "Flavonoides como moduladores do burst oxidativo induzido por nanopartículas de prata em neutrófilos humanos". Paper presented in Encontro Nacional de Estudantes de Bioquímica, 2021.
  37. Mariana Lucas; Marisa Freitas; Artur M. S. Silva; Eduarda Fernandes; Daniela Ribeiro. "Modulation of human neutrophils’ oxidative burst by hydroxylated 2-styrylchromones: the relevance of the catechol group". Paper presented in 1st International Electronic Conference on Biomedicine, 2021.
  38. Sónia Rocha; Mariana Lucas; Vera L. M. Silva; Artur M. S. Silva; Alberto N. Araújo; Rita Guedes; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Antidiabetic Potential of Pyrazoles: Exploring the Structure-Activity Relationship against Protein Tyrosine Phosphatase 1b and Glycogen Phosphorylase". Paper presented in iMed.ULisboa Meeting 2021, 2021.
  39. Adelaide Sousa; Mariana Lucas; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "Comparison of AgNPs toxicity in human monocytes and macrophages". Paper presented in EuroNanoForum, 2021.
  40. Ana T. Rufino; Mariana Lucas; de Oliveira, José Miguel P. Ferreira; Freitas, Paulo; Eduarda Fernandes; Marisa Freitas. Corresponding author: Marisa Freitas. "Flavonoids Modulate the Cytotoxic Effect of Silver Nanoparticles". Paper presented in EuroNanoForum, 2021.
  41. Raquel Santos; Beatriz Moreira; Marisa Freitas; Eduarda Fernandes; José Miguel Oliveira. "Evaluation of antiproliferative effects of fisetin derivatives in osteosarcoma cell lines based on sulforhodamine B assay". Paper presented in IJUP’14th Meeting of Young Researchers of University of Porto, 2021.
  42. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S; Fernandes, Pedro A.; Fernandes, Eduarda; et al. "The potential effect of flavonoids as inhibitors of dipeptidyl peptidase-4 (DPP-4)". Paper presented in IberPhenol - International Conference, 2020.
  43. Mariana Lucas; Daniela Ribeiro; Marisa Freitas; Fabiana Moura; Jadriene Xavier; Marília Goulart; Eduarda Fernandes. "Antioxidant activity of curcumin and piperine extracts and respective combinations". Paper presented in IberPhenol International Conference, 2020.
  44. Adelaide Sousa; Daniela Ribeiro; Catarina M. Correira; Vera L. M. Silva; Artur M.S. Silva; Eduarda Fernandes; Marisa Freitas. "The protective effect of chalcones against human neutrophils’ oxidative burst and NETosis under hyperglycemic conditions". Paper presented in IberPhenol International Conference, 2020.
  45. Marisa Freitas; Carina Proença; Daniela Ribeiro; Sara M. Tomé; Alberto N. Araújo; Artur M.S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "In vitro inhibitory activity of flavonoids against important targets related to type 2 diabetes mellitus". Paper presented in IberPhenol International Conference, 2020.
  46. Ana Rufino; Adelaide Sousa; José Miguel P. Ferreira de Oliveira; Daniela Ribeiro; Manuel Gónzalez-Gómez; José Rivas; Paulo Freitas; Eduarda Fernandes; Marisa Freitas. "In vitro protective effect of flavonoids against intestinal toxicity of silver nanoparticles". Paper presented in IberPhenol International Conference, 2020.
  47. Marisa Freitas; Carina Proença; Mafalda Sarraguça; Daniela Ribeiro; Eduarda Fernandes. "Assessment of HOCl production in human blood experimental optimization and proof of concept for the antioxidant activity of flavonoids in this complex matrix". Paper presented in 27th Annual Conference of Society for Redox Biology and Medicine, 2020.
  48. Sónia Rocha; Daniela Ribeiro; Vera L. M. Silva; Pedro M. O. Gomes; Artur M.S. Silva; Alberto Nova Araújo; M Luisa Corvo; et al. Corresponding author: Marisa Freitas. "Insight into the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of pyrazoles". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  49. Mariana Lucas; Marisa Freitas; Artur M.S. Silva; Eduarda Fernandes; Daniela Ribeiro. "Structure-related antioxidant and anti-inflammatory activities of flavonoids and 2-styrylchromones". Paper presented in 22nd International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, 2020.
  50. Marisa Freitas; Adelaide Sousa; Tânia Soares; Daniela Ribeiro; Félix Carvalho; Eduarda Fernandes; Eduarda Fernandes; et al. "The role of calcium in silver nanoparticles-induced human neutrophils’ oxidative burst". Paper presented in SOT 59th Annual Meeting, 2020.
  51. Carina Proença; Marisa Freitas; Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "Flavonoids as modulators of key enzymes in the management of type 2 diabetes: a structure-activity relationship study.". Paper presented in SOT 59th Annual Meeting, 2020.
  52. Mariana Lucas; Daniela Ribeiro; Marisa Freitas; Fabiana Moura; Jadriene Xavier; Marília Goulart; Eduarda Fernandes. "Evaluation of the antioxidant activity of curcumin and piperine extracts, and their combination, in in vitro cellular and non-cellular systems". Paper presented in 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica, 2020.
  53. Marisa Freitas (Presenter); Sónia Rocha; Carina Proença; Daniela Ribeiro; Alberto N. Araújo; Artur M.S. Silva; Eduarda Fernandes. "Flavonoids versus chalcones: which are the most efficient inhibitors of key digestive enzymes in the management of diabetes mellitus?". Paper presented in 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica, 2020.
  54. Sónia Rocha; Luísa Corvo; Eduarda Fernandes; Marisa Freitas; Eduarda Fernandes. "Optimization of kinetic parameters to assess glycogen phosphorylase activity using a microanalysis method". Paper presented in 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica, 2020.
  55. Carina Proença; Marisa Freitas; Daniela Ribeiro; Sara M. Tomé; Artur M.S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "The promising effect of flavonoids in type 2 diabetes therapy: inhibition of key enzymatic targets with a significant role in the development of hyperglycaemia". Paper presented in 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica, 2020.
  56. Carina Proença; Marisa Freitas; Daniela Sofia Almeida Ribeiro; Artur M.S. Silva; Pedro A. Fernandes. "Dipeptidyl peptidase-4 inhibition by flavonoids is hindered in protein rich environments". Paper presented in 11th Joint Meeting on Medicinal Chemistry, 2019.
  57. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Tomé, Sara M.; Araújo, Alberto N.; Silva, Artur M. S.; Fernandes, Pedro A.; et al. "Promising inhibitory activity of flavonoids against important targets related with type 2 diabetes mellitus". Paper presented in JMMC 2019 - Joint Meeting in Medicinal Chemistry, 2019.
  58. Martins, Thaise; Sousa, Adelaide; Freitas, Marisa; Correia, Catarina M.; Silva, Vera L. M.; Lima, José L. F. C.; Fernandes, Eduarda; et al. "Modulation of human neutrophils¿ oxidative burst by 2¿-hydroxychalcone derivatives". Paper presented in Medicinal Chemistry Frontiers 2019, 2019.
  59. Sousa, Adelaide; Martins, Thaise; Correia, Catarina M.; Silva, Vera L. M.; Silva, Artur; Lima, José L. F. C.; Ribeiro, Daniela; et al. "Impact of chalcones on reactive species production by human neutrophils in hyperglycaemia conditions". Paper presented in EuroFoodChem XX Conference, 2019.
  60. Eduarda das Graças Rodrigues Fernandes; Ana Rufino; Miguel Oliveira; Daniela Sofia Almeida Ribeiro; Adelaide Sousa; Tânia Soares; Manuel Gónzalez-Gómez; et al. "Testing the effects of silver nanoparticles in in vitro models of intestinal toxicity and inflammation". Paper presented in 10th International Conference Biomaterials and Nanobiomaterials: Recent Advances Safety-Toxicology and Ecological Issues, 2019.
  61. Marta Silva; Marisa Freitas; Félix Carvalho; Eduarda Fernandes; Daniela Ribeiro. "Anti- versus pro-oxidant effects of the carotenoids ß-carotene, trans-ß-apo-8'-apocarotenal and ß-cryptoxanthin in a synaptosomal lipid peroxidation model". Paper presented in Encontro de Investigação Jovem da Universidade do Porto (IJUP), 2019.
  62. Diana Pinto; Ana F. Vinha; Freitas, Marisa; M. Beatriz P.P. Oliveira. "Adansonia digitata fruit: Bioactive compounds and antioxidant activity against reactive species (CP031)". Paper presented in XIV Encontro de Química dos Alimentos (XIV EQA), 2018.
  63. Carina Proença; Marisa Freitas; Daniela Ribeiro; Artur M. S. Silva; Pedro A. Fernandes; Eduarda Fernandes; Proenca, Carina; et al. "Development of in vitro and ex vivo methods for the evaluation of dipeptidyl peptidase-4 activity". Paper presented in XXII Encontro Luso-Galego de Química, 2018.
  64. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda; et al. "Inhibitory activity of flavonoids on digestive enzymes a-amylase and a-glucosidase". Paper presented in 10º Simpósio de Metabolismo, 2018.
  65. Pedro Nicola; Marisa Freitas; Sónia Rocha; Félix Carvalho; Eduarda Fernandes; Daniela Ribeiro; Eduarda das Graças Rodrigues Fernandes; et al. "Optimization of a synaptosomal model to study the effect of carotenoids in the peroxynitrite - induced lipid peroxidation". Paper presented in YES (Young European Scientist) Meeting, 2018.
  66. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda; Carina Proença; et al. "The possible role of flavonoids in the management of diabetes mellitus: a structure-activity relationship on enzymes involved in hyperglycaemia". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry - MedChemSicily2018, 2018.
  67. Pedro Nicola; Marisa Freitas; Sónia Rocha; Félix Carvalho; Eduarda Fernandes. "Synaptosomes as lipid models to study the inhibition of peroxynitrite - induced lipid peroxidation". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry, 2018.
  68. Sónia Rocha; Eduarda Fernandes; Marisa Freitas. "Screening of the anti-diabetic potential of chalcones through the inhibition of alpha-glucosidase and alpha-amylase". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry, 2018.
  69. Adelaide Sousa; Eduarda Fernandes; Marisa Freitas; Sousa, Adelaide; Freitas, Marisa; Fernandes, Eduarda. "Flavonoids are promising modulators of diabetes mellitus through the inhibition of alpha-glucosidase". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 11ª Edição, 2018.
  70. Sónia Rocha; Eduarda Fernandes; Marisa Freitas. "Inhibitory activity of chalcones on key digestive enzymes for the management of Diabetes mellitus". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 11ª Edição, 2018.
  71. Sousa, Joana L. C.; Proença, Carina; Freitas, Marisa; Fernandes, Eduarda; Silva, Artur M. S.; Joana L. C. Sousa; Carina Proença; et al. "Synthesis and in vitro antioxidant activity of new polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones". Paper presented in Transmediterranean Colloquium on Heterocyclic Chemistry (TRAMECH) IX, 2017.
  72. Adelaide Sousa; Sílvia Rocha; Marisa Freitas; Daniela Ribeiro; Eduarda Fernandes. "Effect of ß-Carotene and its oxidation products in the oxidative burst of human neutrophils". Paper presented in XXIII Encontro Galego-Portugues de Química, 2017.
  73. Daniela Ribeiro; Adelaide Sousa; Sílvia Rocha; Marisa Freitas; Eduarda Fernandes; Ribeiro, Daniela; Sousa, Adelaide; et al. "ß-Carotene and its biological oxidation products: are they good modulators of pro-oxidant reactive species in human blood and neutrophils assay systems?". Paper presented in Meeting of the International HNE-Club and the University of Graz - Reactive Oxygen Species and Lipid Peroxidation in Human Health and Disease, 2017.
  74. Proença, Carina; Ribeiro, Daniela; Tomé, Sara M.; Silva, Artur M. S.; Freitas, Marisa; Fernandes, Eduarda. "Inhibition of a-glucosidase by chlorinated flavonoids". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - IJUP 10ª Edição, 2017.
  75. Adelaide Sousa; Eduarda Fernandes; Marisa Freitas. "Optimization of a micro-analysis assay for alpha-glucosidase activity". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 10ª Edição, 2017.
  76. Carina Proença; Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Marisa Freitas; Eduarda Fernandes. "Inhibition of alpha-Glucosidase by Chlorinated Flavonoids". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 10ª Edição, 2017.
  77. Tânia Soares; Carina Proença; Mafalda Sarraguça; Eduarda Fernandes; Marisa Freitas. "Optimization of experimental settings for the analysis of reactive oxygen and nitrogen species production in human blood using DCFH-DA". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 10ª Edição, 2017.
  78. Sousa, Adelaide; Freitas, Marisa; Fernandes, Eduarda. "Optimization of a micro-analysis assay for a-glucosidase activity". Paper presented in 10th Edition of the University of Porto Youth Research Meeting, 2017.
  79. Freitas, Marisa; Proença, Carina; Ribeiro, Daniela; Fernandes, Eduarda; Marisa Freitas (Presenter); Carina Proença; Daniela Ribeiro; Eduarda Fernandes. "Assessing the production of reactive and nitrogen species by human neutrophils". Paper presented in Inflammation, Immunity and Cancer: Neutrophils and Other Leukocytes - The Society for Leukocyte Biology¿s 49 th Annual Meeting With Joint Participation By Neutro2016,, 2016.
  80. Carina Proença; Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Eduarda Fernandes; Marisa Freitas. "Chlorinated flavonoids are effective modulators of hypochlorous acid production, both in isolated human neutrophils and whole blood". Paper presented in The Society for Leukocyte Biology’s 49th Annual Meeting and “Neutrophil 2016”, 2016.
  81. Daniela Ribeiro; Sara M. Tomé; Carina Proença; Artur M. S. Silva; Marisa Freitas; Eduarda Fernandes. "Flavonoids - mediated inflammation resolution: their role in human neutrophils' oxidative burst modulation and inhibition of leukotriene B4 production". Paper presented in The Society for Leukocyte Biology’s 49th Annual Meeting and “Neutrophil 2016”, 2016.
  82. Joana Schuelter Boeing; Daniela Ribeiro; Vera Marisa Costa; Jesuí V. Visentainer; Marisa Freitas; Eduarda Fernandes. ". Bactris setosa, an underexploited brazilian fruit, shows protective effects against oxidative cellular damage". Paper presented in Sociedade Portuguesa de Química- Divisão de Química Alimentar, 2016.
  83. Ribeiro, Daniela (presenter); Tomé, S.M.; Proenca, Carina; Silva, A.M.S.; Freitas, Marisa; Fernandes, Eduarda. "Flavonoids can mediate inflammation resolution through inhibition of human neutrophils¿ oxidative burst and leukotriene B4 production". Paper presented in The Society For Leukocytes Biology¿s 49th Annual Meeting and ¿Neutrophil 2016¿, 2016.
  84. Proença, Carina; Albuquerque, Hélio; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda. "Novel chromones and xanthones target reactive nitrogen species in vitro". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 9th Edition, 2016.
  85. Renan Campos Chisté; Daniela Ribeiro; Marisa Freitas; Andreia Leite; Tânia Moniz; Maria Rangel; Eduarda Fernandes; et al. "Metal ion complexes with 3-hydroxy-4-pyridinone ligands as inhibitors of neutrohpils’ oxidative burst". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, 2015.
  86. Paula Silva; Diana Couto; Marisa Freitas; Vera Marisa Costa; Renan Campos Chisté; M. Arturo Lopez Quintela; José Rivas; et al. "Clearance and biocompatibility of polyacrylic acid-coated iron oxide nanoparticles in mice". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, 2015.
  87. Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Fernandes, Eduarda. "The antioxidant activity of novel chromones and xanthones: a structure-activity relationship". Paper presented in XXI Encontro Luso-Galego de Química, 2015.
  88. Paula Silva; Daniela Ribeiro; Carina Proença; Eduarda Fernandes; Marisa Freitas. "The effect of flavonoids in inflammatory pathways". Paper presented in 7th International Conference on Polyphenols and Health (ICPH), 2015.
  89. Tânia Soares; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas; Larine Kupski; Elane Badiale Furlong; Sara M. Tomé; et al. Corresponding author: Freitas, Marisa. "Size-dependent cytotoxicity of silver nanoparticles in human neutrophils". Paper presented in 51st Congress of the European Societies of Toxicology, 2015.
    10.1016/J.TOXLET.2015.08.640
  90. Marisa Freitas (Presenter); Tânia Soares; Daniela Ribeiro; Eduarda Fernandes. "Comparison of different methods to assess the viability of human neutrophils". Paper presented in XXIV Encontro Nacional da Sociedade Portuguesa de Química, 2015.
  91. Daniela Ribeiro; Marisa Freitas; Eduarda Fernandes. "Effect of flavonoids in the human neutrophils' apoptotic pathways". Paper presented in 9th World Congress on Polyphenols Applications, 2015.
  92. Marisa Freitas (Presenter); Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Eduarda Fernandes. "Chlorinated flavonoids modulate the oxidative burst of inflammatory cells". Paper presented in 9th World Congress on Polyphenols Applications, St Julian's, 2015.
  93. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Silva, Artur M. S.; Fernandes, Eduarda; Carina Proença; et al. "In vitro antioxidant activity of novel 3-hydroxy-2-styrylchromones as compared to 3-hydroxyflavones". Paper presented in Congresso de Química Orgânica e Química Terapêutica, 2015.
  94. Larine Kupski; Marisa Freitas; Eliana Badiale Furlong; Eduarda Fernandes. "Interação da ocratoxina A com neutrófilos humanos in vitro". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  95. Renan Campos Chisté; Alessandra Braga Ribeiro; Marisa Freitas; Jesuí V. Visentainer; Eduarda Fernandes. "Flacourtia jangomas L. fruit: bioactive compounds and scavenging capacity against reactive nitrogen species". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  96. Marisa Freitas (Presenter); Daniela Ribeiro; Sara M. Tomé; Artur M. S. Silva; Eduarda Fernandes. "Chlorinated flavonoids as potential modulators of apoptosis in human neutrohpils". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  97. Diana Couto; Marisa Freitas; Graça Porto; M. Arturo Lopez Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes. "Polyacrylic acid coated and non-coated iron oxide nanoparticles activate inflammatory pathways in human blood". Paper presented in BioNanoMed 5th International Congress: Nanotechnology, Biology & Medicine, 2014.
  98. Alessandra Braga Ribeiro; Renan Campos Chisté; Marisa Freitas; Alex F. Silva; Jesuí V. Visentainer. "Efeito antioxidante in vitro do extrato da polpa e da casca de Psidium cattleianum. XIX". Paper presented in Encontro Galego-Portugués de Química, 2013.
  99. Renan Campos Chisté; Marisa Freitas; Adriana Zerlotti Mercadante; Eduarda Fernandes. "Carotenoids protect human erythrocytes against oxidative damage induced by peroxyl radicals". Paper presented in Antioxidants and Redox Process in Health. Bilateral Meeting Brazil-Japan, 2013.
  100. Daniela Ribeiro; Marisa Freitas; Sara M. Tomé; Artur M. S. Silva; Graça Porto; Eduarda Fernandes; Freitas, Marisa; Artur M.S. Silva. "A structure-activity relationship study of flavonoids as dual inhibitors of LOX and COX". Paper presented in SFRR-Europe Conference: The new era of –omics in Free Radicals in Biology and Medicine, 2013.
    10.1016/J.FREERADBIOMED.2013.08.075
  101. Renan Campos Chisté; Marisa Freitas; Adriana Zerlotti Mercadante; Eduarda Fernandes. "Peroxyl radical–induced hemolysis assay: optimization by response surface methodology and carotenoid action.". Paper presented in XXIII Encontro Nacional da SPQ, 2013.
  102. Daniela Ribeiro; Marisa Freitas; Sara M. Tomé; Artur M. S. Silva; Graça Porto; Eduarda Fernandes. "Falvonoids and LOX- an interaction and inhibition study". Paper presented in XXIII Encontro Nacional da SPQ, 2013.
  103. Ribeiro, Daniela (presenter); Freitas, Marisa; Tomé, S.M.; Silva, A.M.S.; Porto, G.; Fernandes, Eduarda. "Flavonoids and LOX ¿ an interaction and inhibition study". Paper presented in XXIII Encontro Nacional da SPQ, 2013.
  104. Irene Dias; Diana Couto; Marisa Freitas; Graça Porto; M. Arturo Lopez Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes. "Polyacrylic acid and naked iron oxide nanoparticles modulate neutrophils’ oxidative burst and apoptosis". Paper presented in IJUP 2013 – 6th Meeting of Young Researchers of University of Porto, 2013.
  105. Marisa Freitas (Presenter); Graça Porto; Félix Carvalho; Eduarda Fernandes. "Acetaminophen prevents human neutrophils’ oxidative burst through scavenging of HOCl and H2O2". Paper presented in 3º Encontro Nacional de Química Terapêutica, 2012.
  106. Diana Couto; Marisa Freitas; Graça Porto; M. Arturo Lopez Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes. "Polyacrylic acid coated versus naked iron oxide nanoparticles: its effect on the death mechanisms of human neutrophils". Paper presented in 3º Encontro Nacional de Química Terapêutica, 2012.
  107. Marisa Freitas (Presenter); Diana Couto; M. Arturo Lopez Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes; et al. "Iron oxide nanoparticles stimulate oxidative burst and accelerate apoptosis in human neutrophils". Paper presented in 16th biennial meeting for the Society for Free Radical Research International, 2012.
  108. Renan Campos Chisté; Marisa Freitas; Adriana Zerlotti Mercadante; Eduarda Fernandes. "Pulp extracts of Piquiá (caryocar villosum) are highly effective in scavenging hipochlorous acid and singlet oxygen". Paper presented in XXIII Congresso Brasileiro de Ciência e Tecnologia de Alimentos, 2012.
  109. Enma Conde ; Elena M. Balboa; Beatriz Diaz Reinoso; Daniela Ribeiro; Marisa Freitas; Eduarda Fernandes; Andrés Moure; Herminia Domínguez ; Juan C. Parajó. "Screening of anti-inflammatory potencial in natural extracts with high polyphenolic content". Paper presented in Jornada de Investigación Biomédica, 2012.
  110. Marisa Freitas (Presenter); Pedro Barcellos-de-Sousa; Christina Barja-Fidalgo; Eduarda Fernandes; Freitas, M.; Barcellos-de-Souza, P.; Barja-Fidalgo, C.; Fernandes, E.. "Nickel induces apoptosis in human neutrophils". Paper presented in Second International Conference on Environmental Stressors in Biology and Medicine, 2011.
    10.1007/s10534-012-9590-2
  111. Renan Campos Chisté; Marisa Freitas; Adriana Zerlotti Mercadante; Eduarda Fernandes. "The phenolic composition of Caryocar villosum extracts is associated to the potential to scavenge reactive oxygen and nitrogen species". Paper presented in 5th International Conference on Ployphenols and Health, 2011.
  112. Beatriz Diaz Reinoso; Ana Gomes; Marisa Freitas; Eduarda Fernandes; Andrés Moure; J. González Méndez; Herminia Domínguez ; A. Levoso Touceda; Juan C. Parajó. "Radical scavenging activity of antioxidants from wine vinasses,". Paper presented in Wine Active Compounds, WAC 2011, 2011.
  113. Noelia González; Ana Gomes; Marisa Freitas; Andrés Moure; Herminia Domínguez González; Eduarda Fernandes; Juan C. Parajó. "Ethanolic extracts from Cytisus scoparius hold potent antioxand activity.". Paper presented in XVI Encontro Luso-Galego de Química, 2010.
  114. Beatriz Diaz Reinoso; Ana Gomes; Marisa Freitas; Andrés Moure Varela; Herminia Domínguez ; Eduarda Fernandes; Juan C. Parajó. "Antioxidant activity of a white wine vinasse extract". Paper presented in XVI Encontro Luso-Galego de Química, 2010.
  115. Eduarda Fernandes; Marisa Freitas; Graça Porto; José L. F. C. Lima. "Optimização de condições experimentais para detecção do "burst" oxidativo em neutrófilos humanos". Paper presented in IV Congresso Iberoamericano de Química Analítica; X Encuentro Nacional de Química Analítica y Ambiental, 2010.
  116. Clementina M.M. Santos; Marisa Freitas; Daniela Ribeiro; Ana Gomes; Artur M. S. Silva; José A.S. Cavaleiro; Eduarda Fernandes. "NDPO2 as a selective generator of 1O2 used in the scavenging activity assay of 2,3-diarylxanthones.". Paper presented in Segundo Simpósio Iberoamericano de Química Orgânica, 2010.
  117. Clementina M.M. Santos; Marisa Freitas; Daniela Ribeiro; Ana Gomes; Artur M. S. Silva; José A.S. Cavaleiro; Eduarda Fernandes. "ROS and RNS scavenging activity by 2,3-diarylxanthones.". Paper presented in Internacional Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species, 2010.
  118. Ana Gomes; Marisa Freitas; João P. Capela; Artur M. S. Silva; Diana C.G.A. Pinto; Clementina M.M. Santos; José A.S. Cavaleiro; et al. "The 2-styrylchromone structure is an effective scaffold for the development of new inhibitors of the NF-kB pathway.". Paper presented in EMBO Conference Cellular Signaling & Molecular Medicine, 2010.
  119. Rita Reis; Daniela Ribeiro; Ana Gomes; Marisa Freitas; Mónica S. Estevão; Maria Manuel B. Marques; José L.F.C. Lima; Eduarda Fernandes. "Inhibition of cyclooxygenases by new indole derivatives.". Paper presented in 3º IJUP (Investigação Jovem na Universidade do Porto), 2010.
  120. Couto, Diana (presenter); Ribeiro, Daniela; Costa, Diana; Gomes, Ana; Freitas, Marisa; Fernandes, Eduarda; Daniela Ribeiro; et al. "Scavenging activities of sulfasalazine and its metabolites, sulfapyridine and 5-aminosalicylic acid, against reactive nitrogen species". Paper presented in IJUP¿10 3rd meeting of young researchers of U. Porto, 2010.
  121. José L. F. C. Lima; Ana Gomes; Ondrej Neuwirth; Marisa Freitas; Diana Couto; Daniela Ribeiro; Andrea G.P.R. Figueiredo; et al. "Utilização da di-hidrorodamina 123 para a detecção de espécies reactivas de oxigénio e de azoto em metodologias de micro-análise.". Paper presented in 15º. ENQA-Encontro Nacional de Química Analítica e 3º CIAQA - Congresso Iberoamericano de Química Analítica, 2009.
  122. Eduarda Fernandes; Marisa Freitas; Graça Porto; José L. F. C. Lima. "Utilização do luminol para a detecção de espécies reactivas produzidas por neutrófilos humanos estimulados com cloreto de cádmio". Paper presented in 15º. ENQA-Encontro Nacional de Química Analítica e 3º CIAQA - Congresso Iberoamericano de Química Analítica, 2009.
  123. Marisa Freitas (Presenter); Ana Gomes; Eduarda Fernandes; José L. F. C. Lima. "Cadmium activates NF-kB and production of cytokines in THP-1 monocytes". Paper presented in 4th International Conference on Oxidative/Nitrosative Stress and Disease, 2009.
  124. Freitas, Marisa. "Inflammatory cell signalling is affected by 2-styrylchromones. Studies of NF-kB activation and pro-inflammatory cytokines production in THP-1 monocytes". Paper presented in 4th International Conference on Oxidative/Nitrosative Stress and Disease, 2009.
  125. Marisa Freitas (Presenter); Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "Zinc activates via protein kinase C and catalyses the interconversion among reactive species in human neutrophils". Paper presented in 1º Encontro Nacional de Química Terapêutica-Sociedade Portuguesa de Química, 2008.
  126. Marisa Freitas (Presenter); Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "Nickel salts induce oxidative burst in neutrophils via activation of protein kinase C.". Paper presented in 14th Biennial Meeting of the Society for Free Radical Research International, 2008.
  127. Marisa Freitas (Presenter); Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "Interference of zinc in the activation of human neutrophils and subsequent oxidative burst.". Paper presented in 9th European Biological Inorganic Chemistry Conference, 2008.
  128. Marisa Freitas (Presenter); Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "Importance of glucose for human neutrophils’ oxidative burst in vitro.". Paper presented in Encontro Nacional da Sociedade Portuguesa de Química, 2008.
  129. Marisa Freitas (Presenter); Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "The oxidative burst of human neutrophils in vitro is highly dependent on buffering agents". Paper presented in AOAC Europe Section International Workshop– Enforcement of European Legislation on Food and Water: Analytical and Toxicological Aspects e II Encontro Nacional de Bromatologia, Hidrologia e Toxicologia, 2008.
  130. Ana Gomes; Eduarda Fernandes; Marisa Freitas; Artur M. S. Silva; Clementina M.M. Santos; Diana C.G.A. Pinto; José A.S. Cavaleiro; et al. "Inhibition of leukotriene B4 production in human neutrophils by 2-styrylchromones". Paper presented in Society for Free Radical Research-Europe 2007 Meeting, 2007.
  131. Marisa Freitas (Presenter); Eduarda Fernandes; José L. F. C. Lima. "Metodologia de micro-análise para quantificação de cálcio livre intracelular livre em neutrófilos humanos". Paper presented in 6º Encontro Nacional da Divisão de Química Analítica- Sociedade Portuguesa de Química, 2007.
  132. Marisa Freitas (Presenter); Ana Gomes; David Costa; José L. F. C. Lima. "Antioxidant activity of beta-blockers. An effect mediated by scavenging reactive oxygen and nitrogen species?". Paper presented in 4º Encontro do REQUIMTE: Rede de Química e Tecnologia, 2006.
Encyclopedia entry
  1. Regina Menezes; Paulo Matafome; Freitas, Marisa; María-Teresa García-Conesa. "The Evidence of Benefits of (Poly)phenols against T2DM". In Escholarly Community Encyclopedia, 2022.
Journal article
  1. Ana F. Vinha; Anabela S. G. Costa; Filipa B. Pimentel; Liliana Espírito Santo; Carla Sousa ou Carla Sousa e Silva; Freitas, Marisa; Eduarda Fernandes; M. Beatriz P.P. Oliveira. "Bioactive compounds and scavenging capacity of Adansonia digitata L. (baobab fruit) pulp extracts against ROS and RNS of physiological relevance". Applied Sciences 14 8 (2024): 3408. https://www.mdpi.com/2076-3417/14/8/3408.
    Published • 10.3390/app14083408
  2. Santos, Clementina M. M.; Proença, Carina; Freitas, Marisa; Araújo, Alberto N.; Silva, Artur M. S.; Fernandes, Eduarda. Corresponding author: Fernandes, Eduarda. "2-Styrylchromones as inhibitors of a-amylase and a-glucosidase enzymes for the management of type 2 diabetes mellitus". Medicinal Chemistry Research (2024): http://dx.doi.org/10.1007/s00044-024-03200-8.
    Published • 10.1007/s00044-024-03200-8
  3. Rocha, Sónia; Amaro, Andreia; Ferreira-Junior, Marcos D.; Proença, Carina; Silva, Artur M. S.; Costa, Vera M.; Oliveira, Sara; et al. "Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus". Pharmaceutics 16 2 (2024): 261. http://dx.doi.org/10.3390/pharmaceutics16020261.
    10.3390/pharmaceutics16020261
  4. Rocha, Sónia; AMARO, ANDREIA; Marcos D. Ferreira-Junior; Proença, Carina; Silva, Artur M. S.; Vera M. Costa; Sara Oliveira; et al. "A hydroxylated flavonoid reduces oxidative stress in an animal model of type 2 diabetes mellitus". (2024):
    Submitted
  5. Steinmetz, Jaimie D; Culbreth, Garland T; Haile, Lydia M; Rafferty, Quinn; Lo, Justin; Fukutaki, Kai Glenn; Cruz, Jessica A; et al. "Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet Rheumatology 5 9 (2023): e508-e522. http://dx.doi.org/10.1016/s2665-9913(23)00163-7.
    10.1016/s2665-9913(23)00163-7
  6. Rufino, Ana T.; Freitas, Marisa; Proença, Carina; Ferreira de Oliveira, José M. P.; Fernandes, Eduarda; Ribeiro, Daniela. "Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy". Medicinal Research Reviews (2023): http://dx.doi.org/10.1002/med.21990.
    10.1002/med.21990
  7. Rufino, Ana T.; Freitas, Marisa; Proença, Carina; Ferreira de Oliveira, José M. P.; Fernandes, Eduarda; Ribeiro, Daniela. "Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy". Medicinal Research Reviews 44 2 (2023): 497-538. http://dx.doi.org/10.1002/med.21990.
    10.1002/med.21990
  8. Rufino, Ana T.; Freitas, Marisa; Proença, Carina; Ferreira de Oliveira, José M. P.; Fernandes, Eduarda; Ribeiro, Daniela. "Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy". Medicinal Research Reviews 44 2 (2023): 497-538. http://dx.doi.org/10.1002/med.21990.
    10.1002/med.21990
  9. Sousa, Adelaide; Azevedo, Rui; Costa, Vera Marisa; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; et al. Corresponding author: Freitas, Marisa. "Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice". Archives of Toxicology 97 10 (2023): 2643-2657. http://dx.doi.org/10.1007/s00204-023-03558-5.
    10.1007/s00204-023-03558-5
  10. Rocha, Sílvia; Rufino, Ana T.; Freitas, Marisa; Silva, Artur M. S.; Carvalho, Félix; Fernandes, Eduarda. "Methodologies for Assessing Pancreatic Lipase Catalytic Activity: A Review". Critical Reviews in Analytical Chemistry (2023): 1-28. http://dx.doi.org/10.1080/10408347.2023.2221731.
    10.1080/10408347.2023.2221731
  11. Freitas, Marisa; Proença, Carina; Ribeiro, Daniela; Quinaz-Garcia, Maria Beatriz; Araújo, Alberto N.; Fernandes, Eduarda; Proença, Carina; M. Beatriz Quinaz. "Assessment of a-Amylase Activity in a Microanalysis System: Experimental Optimization and Evaluation of Type of Inhibition". Journal of Chemical Education 100 3 (2023): 1237-1245. http://dx.doi.org/10.1021/acs.jchemed.2c00392.
    Published • 10.1021/acs.jchemed.2c00392
  12. Adelaide Sousa; Ana T. Rufino; Rui Fernandes; Ana Malheiro; Félix Carvalho; Eduarda Fernandes; Marisa Freitas; et al. "Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of ¿¿m and release of pro-inflammatory cytokines". Archives of Toxicology 97 2 (2023): 405-420. https://doi.org/10.1007/s00204-022-03415-x.
    10.1007/s00204-022-03415-x
  13. Proença, Carina; Freitas, Marisa; Ribeiro, Daniela; Rufino, Ana T.; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.; Proença, Carina; et al. Corresponding author: Ferreira de Oliveira, José Miguel P.. "The role of flavonoids in the regulation of epithelial-mesenchymal transition in cancer: a review on targeting signalling pathways and metastasis". Medicinal Research Reviews 43 6 (2023): 1878-1945. http://dx.doi.org/10.1002/med.21966.
    In press • 10.1002/med.21966
  14. Proença, Carina; Rufino, Ana T.; Freitas, Marisa; Fernandes, Eduarda. "Como tratar a obesidade associada à diabetes tipo 2?". Revista de Ciência Elementar (2023):
    Accepted
  15. Amaral, Luísa M.P.F.; Moniz, Tânia; Leite, Andreia; Oliveira, Ana; Fernandes, Pedro; Ramos, Maria João; Araújo, Alberto N.; et al. "A combined experimental and computational study to discover novel tyrosinase inhibitors". Journal of Inorganic Biochemistry 234 (2022): 111879. http://dx.doi.org/10.1016/j.jinorgbio.2022.111879.
    10.1016/j.jinorgbio.2022.111879
  16. Regina Menezes; Paulo Matafome; Marisa Freitas; María-Teresa García-Conesa. "Updated Information of the Effects of (Poly)phenols against Type-2 Diabetes Mellitus in Humans: Reinforcing the Recommendations for Future Research". Nutrients (2022): https://doi.org/10.3390/nu14173563.
    10.3390/nu14173563
  17. Burkart, Katrin; Causey, Kate; Cohen, Aaron J; Wozniak, Sarah S; Salvi, Devashri Digvijay; Abbafati, Cristiana; Adekanmbi, Victor; et al. "Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990–2019: an analysis of data from the Global Burden of Disease Study 2019". The Lancet Planetary Health 6 7 (2022): e586-e600. http://dx.doi.org/10.1016/s2542-5196(22)00122-x.
    10.1016/s2542-5196(22)00122-x
  18. Sónia Rocha; M. Luísa Corvo; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. "The Emerging Target Protein Tyrosine Phosphatase 1B (PTP1B) for Type 2 Diabetes Mellitus Management". Journal of Diabetes and Clinical Research 3 4 (2022): http://dx.doi.org/10.33696/diabetes.3.048.
    Published • 10.33696/diabetes.3.048
  19. Adelaide Sousa; Tracey D. Bradshaw; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas. "Pro-inflammatory effects of silver nanoparticles in the intestine". Archives of Toxicology (2022): https://doi.org/10.1007/s00204-022-03270-w.
    10.1007/s00204-022-03270-w
  20. Adelaide Sousa; Ana Ramalho; Eduarda Fernandes; Marisa Freitas (Correspondig author). Corresponding author: Marisa Freitas (Correspondig author). "Nanopartículas de prata: história, benefícios e aplicações". Revista de Ciência Elementar V10 (2022): 040.
    Published
  21. Cousin, Ewerton; Duncan, Bruce B; Stein, Caroline; Ong, Kanyin Liane; Vos, Theo; Abbafati, Cristiana; Abbasi-Kangevari, Mohsen; et al. "Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019". The Lancet Diabetes & Endocrinology 10 3 (2022): 177-192. http://dx.doi.org/10.1016/s2213-8587(21)00349-1.
    10.1016/s2213-8587(21)00349-1
  22. Mariana Lucas; Marisa Freitas; Marco Zanchetta; Artur M. S. Silva; Eduarda Fernandes; Daniela Ribeiro. "2-Styrylchromones: Cytotoxicity and Modulation of Human Neutrophils’ Oxidative Burst". Pharmaceuticals 15 3 (2022): 288-288. https://doi.org/10.3390/ph15030288.
    10.3390/ph15030288
  23. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; Maria Luísa Corvo; Eduarda Fernandes; Freitas, Marisa (Correspondig author). "An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles". Nutrients (2022): https://doi.org/10.3390/nu14020306.
    10.3390/nu14020306
  24. Carina Proença; Ana T. Rufino; José Miguel P. Ferreira de Oliveira; Marisa Freitas; Pedro A. Fernandes; Artur M. S. Silva; Eduarda Fernandes. "Inhibitory activity of flavonoids against human sucrase-isomaltase (a-glucosidase) activity in a Caco-2/TC7 cellular model". Food & Function (2022): https://doi.org/10.1039/D1FO02995A.
    10.1039/D1FO02995A
  25. Clementina M. M. Santos; Carina Proença; Marisa Freitas; Alberto N. Araújo; Artur M. S. Silva; Eduarda Fernandes; Santos, Clementina M.M.; et al. Corresponding author: Santos, Clementina M.M.. "Inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by hydroxylated xanthones". Food & Function (2022): https://doi.org/10.1039/D2FO00023G.
    Submitted • 10.1039/D2FO00023G
  26. Mariana Lucas; Marisa Freitas; Artur M. S. Silva; Eduarda Fernandes; Daniela Ribeiro; ChongDe Sun. "Styrylchromones: Biological Activities and Structure-Activity Relationship". Oxidative Medicine and Cellular Longevity (2021): https://doi.org/10.1155/2021/2804521.
    10.1155/2021/2804521
  27. Kinyoki, Damaris; Osgood-Zimmerman, Aaron E.; Bhattacharjee, Natalia V.; Schaeffer, Lauren E.; Lazzar-Atwood, Alice; Lu, Dan; Ewald, Samuel B.; et al. "Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018". Nature Medicine 27 10 (2021): 1761-1782. http://dx.doi.org/10.1038/s41591-021-01498-0.
    10.1038/s41591-021-01498-0
  28. Rocha, Sónia; Lucas, Mariana; Araújo, Alberto N.; Corvo, M. Luísa; Fernandes, Eduarda; Freitas, Marisa (Correspondig author); Rocha, Sonia; et al. "Optimization and Validation of an In Vitro Standardized Glycogen Phosphorylase Activity Assay". Molecules 26 15 (2021): 4635. http://dx.doi.org/10.3390/molecules26154635.
    10.3390/molecules26154635
  29. Rocha, Sónia; Lucas, Mariana; Ribeiro, Daniela; Corvo, M. Luísa; Fernandes, Eduarda; Freitas, Marisa (Correspondig author); Rocha, Sonia; Corvo, M. Luisa; Freitas, Marisa. "Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment". Pharmacological Research 169 (2021): 105604. http://dx.doi.org/10.1016/j.phrs.2021.105604.
    10.1016/j.phrs.2021.105604
  30. Lucas, Mariana; Freitas, Marisa; Xavier, Jadriane A.; Moura, Fabiana A.; Goulart, Marília O. F.; Ribeiro, Daniela; Fernandes, Eduarda; Goulart, Marilia O. F.. "The scavenging effect of curcumin, piperine and their combination against physiological relevant reactive pro-oxidant species using in vitro non-cellular and cellular models". Chemical Papers 75 10 (2021): 5269-5277. http://dx.doi.org/10.1007/s11696-021-01710-y.
    10.1007/s11696-021-01710-y
  31. Rocha, Sónia; Lucas, Mariana; Silva, Vera L.M.; Gomes, Pedro M.O.; Silva, Artur M.S.; Araújo, Alberto N.; Aniceto, Natália; et al. "Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study". International Journal of Biological Macromolecules 181 (2021): 1171-1182. http://dx.doi.org/10.1016/j.ijbiomac.2021.04.061.
    10.1016/j.ijbiomac.2021.04.061
  32. Carina Proença; Daniela Ribeiro; Marisa Freitas; Félix Carvalho; Eduarda Fernandes. "A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis". Critical Reviews in Food Science and Nutrition (2021): https://doi.org/10.1080/10408398.2021.1872483.
    10.1080/10408398.2021.1872483
  33. Carina Proença; Daniela Ribeiro; Marisa Freitas; Eduarda Fernandes. "Flavonoids as potential agents in the management of type 2 diabetes through the modulation of a-amylase and a-glucosidase activity: a review". Critical Reviews in Food Science and Nutrition (2021): https://doi.org/10.1080/10408398.2020.1862755.
    10.1080/10408398.2020.1862755
  34. Paulson, Katherine R.; Kamath, Aruna M.; Alam, Tahiya; Bienhoff, Kelly; Abady, Gdiom Gebreheat; Abbas, Jaffar; Abbasi-Kangevari, Mohsen; et al. "Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019". The Lancet (2021): https://publons.com/wos-op/publon/49053268/.
    10.1016/S0140-6736(21)01207-1
  35. Rufino, Ana T.; Ramalho, Ana; Sousa, Adelaide; de Oliveira, Jose Miguel P. Ferreira; Freitas, Paulo; Gomez, Manuel A. Gonzalez; Pineiro-Redondo, Yolanda; et al. "Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles". Molecules 26 21 (2021): 6610. https://publons.com/publon/49686808/.
    10.3390/MOLECULES26216610
  36. Adelaide Sousa; Mariana Lucas; Daniela Ribeiro; Catarina M. Correia; Vera L. M. Silva; Artur M. S. Silva; Eduarda Fernandes; Marisa Freitas. "Chalcones as Modulators of Neutrophil Oxidative Burst under Physiological and High Glucose Conditions". Journal of Natural Products (2020): https://doi.org/10.1021/acs.jnatprod.0c00728.
    10.1021/acs.jnatprod.0c00728
  37. Murray, Christopher J L; Aravkin, Aleksandr Y; Zheng, Peng; Abbafati, Cristiana; Abbas, Kaja M; Abbasi-Kangevari, Mohsen; Abd-Allah, Foad; et al. "Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1223-1249. http://dx.doi.org/10.1016/s0140-6736(20)30752-2.
    10.1016/s0140-6736(20)30752-2
  38. Vos, Theo; Lim, Stephen S; Abbafati, Cristiana; Abbas, Kaja M; Abbasi, Mohammad; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; et al. "Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1204-1222. http://dx.doi.org/10.1016/s0140-6736(20)30925-9.
    10.1016/s0140-6736(20)30925-9
  39. Wang, Haidong; Abbas, Kaja M; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; Abd-Allah, Foad; Abdelalim, Ahmed; et al. "Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1160-1203. http://dx.doi.org/10.1016/s0140-6736(20)30977-6.
    10.1016/s0140-6736(20)30977-6
  40. Murray, Christopher J L; Abbafati, Cristiana; Abbas, Kaja M; Abbasi, Mohammad; Abbasi-Kangevari, Mohsen; Abd-Allah, Foad; Abdollahi, Mohammad; et al. "Five insights from the Global Burden of Disease Study 2019". The Lancet 396 10258 (2020): 1135-1159. http://dx.doi.org/10.1016/s0140-6736(20)31404-5.
    10.1016/s0140-6736(20)31404-5
  41. Adelaide Sousa; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas. "The effect of chalcones on the main sources of reactive species production: possible therapeutic implications in diabetes mellitus". Current Medicinal Chemistry (2020): https://doi.org/10.2174/0929867327666200525010007.
    10.2174/0929867327666200525010007
  42. Proença, Carina; Oliveira, Ana; Freitas, Marisa; Ribeiro, Daniela; Sousa, Joana L. C.; Ramos, Maria J.; Silva, Artur M. S.; Fernandes, Pedro A.; Fernandes, Eduarda. "Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase". Journal of Natural Products 83 5 (2020): 1541-1552. http://dx.doi.org/10.1021/acs.jnatprod.0c00014.
    10.1021/acs.jnatprod.0c00014
  43. Freitas, Marisa (Correspondig author); Lucas, Mariana; Sousa, Adelaide; Soares, Tânia; Ribeiro, Daniela; Carvalho, Félix; Fernandes, Eduarda. "Small-size silver nanoparticles stimulate neutrophil oxidative burst through an increase of intracellular calcium levels". World Academy of Sciences Journal 2 (2020): 1-8. http://dx.doi.org/10.3892/wasj.2020.46.
    Published • 10.3892/wasj.2020.46
  44. Bikbov, Boris; Purcell, Caroline A; Levey, Andrew S; Smith, Mari; Abdoli, Amir; Abebe, Molla; Adebayo, Oladimeji M; et al. "Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet (2020): http://dx.doi.org/10.1016/s0140-6736(20)30045-3.
    10.1016/s0140-6736(20)30045-3
  45. Daniela Ribeiro; Adelaide Sousa; Pedro Nicola; José Miguel P. Ferreira; Ana Rufino; Marta Silva; Marisa Freitas; Félix Carvalho; Eduarda Fernandes. "ß-Carotene and its physiological metabolites: effects on oxidative status regulation and genotoxicity in in vitro models". Food and Chemical Toxicology (2020):
    Accepted
  46. Abbafati, Cristiana; Abbas, Kaja M.; Abbasi, Mohammad; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; Abd-Allah, Foad; et al. "Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet (2020): https://publons.com/wos-op/publon/34647573/.
    10.1016/S0140-6736(20)30925-9
  47. Murray, Christopher J. L.; Aravkin, Aleksandr Y.; Zheng, Peng; Abbafati, Cristiana; Abbas, Kaja M.; Abbasi-Kangevari, Mohsen; Abd-Allah, Foad; et al. "Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet (2020): https://publons.com/wos-op/publon/34651472/.
    10.1016/S0140-6736(20)30752-2
  48. Abbafati, Cristiana; Abbas, Kaja M.; Abbasi, Mohammad; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; Abd-Allah, Foad; et al. "Five insights from the Global Burden of Disease Study 2019". The Lancet (2020): https://publons.com/wos-op/publon/34647572/.
    10.1016/S0140-6736(20)31404-5
  49. Wang, Haidong; Abbas, Kaja M.; Abbasifard, Mitra; Abbasi-Kangevari, Mohsen; Abbastabar, Hedayat; Abd-Allah, Foad; Abdelalim, Ahmed; et al. "Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019". The Lancet (2020): https://publons.com/wos-op/publon/34647762/.
    10.1016/S0140-6736(20)30977-6
  50. Ribeiro, Daniela; Sousa, Adelaide; Nicola, Pedro; Ferreira de Oliveira, Jose Miguel P.; Rufino, Ana T.; Silva, Marta; Freitas, Marisa; Carvalho, Felix; Fernandes, Eduarda. "beta-Carotene and its physiological metabolites: Effects on oxidative status regulation and genotoxicity in in vitro models". Food and Chemical Toxicology (2020): https://publons.com/publon/33324092/.
    10.1016/J.FCT.2020.111392
  51. Freitas, Marisa; Proenca, Carina; Sarraguca, Mafalda; Ribeiro, Daniela; Fernandes, Eduarda. "Assessment of HOCl Production in Human blood: Experimental Optimization and Proof of Concept for the Antioxidant Activity of Flavonoids in this Complex Matrix". Free Radical Biology and Medicine (2020): https://publons.com/wos-op/publon/35806302/.
    10.1016/J.FREERADBIOMED.2020.10.119
  52. Fitzmaurice, Christina; Abate, Degu; Abbasi, Naghmeh; Abbastabar, Hedayat; Abd-Allah, Foad; Abdel-Rahman, Omar; Abdelalim, Ahmed; et al. "Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017". JAMA Oncology 5 12 (2019): 1749. http://dx.doi.org/10.1001/jamaoncol.2019.2996.
    10.1001/jamaoncol.2019.2996
  53. Rosa Direito; João Rocha; Ana-Teresa Serra; Adelaide Fernandes; Marisa Freitas; Eduarda Fernandes; Rui Pinto; et al. "Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis". Journal of Dietary Supplements (2019): https://doi.org/10.1080/19390211.2019.1645256.
    10.1080/19390211.2019.1645256
  54. Tânia Soares; Daniela Rodrigues; Mafalda Sarraguça; Sílvia Rocha; José L. F. C. Lima; Daniela Ribeiro; Eduarda Fernandes; Marisa Freitas (Corresponding author). "Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood". Oxidative Medicine and Cellular Longevity (2019): https://doi.org/10.1155/2019/7198484.
    10.1155/2019/7198484
  55. Carina Proença; Marisa Freitas; Daniela Ribeiro; Sara M. Tomé; Eduardo F. T. Oliveira; Matilde F. Viegas; Alberto N. Araújo; et al. "Evaluation of a flavonoids library for inhibition of pancreatic alpha-amylase towards a structure–activity relationship". Journal of Enzyme Inhibition and Medicinal Chemistry (2019): https://doi.org/10.1080/14756366.2018.1558221.
    10.1080/14756366.2018.1558221
  56. Carina Proença; Marisa Freitas; Daniela Ribeiro; Sara M. Tomé; Alberto N. Araújo; Artur M. S. Silva; Pedro A. Fernandes; Eduarda Fernandes. "The dipeptidyl peptidase-4 inhibitory effect of flavonoids is hindered in protein rich environments". Food & Function (2019): https://doi.org/10.1039/C9FO00722A.
    10.1039/C9FO00722A
  57. Sónia Rocha; Adelaide Sousa; Daniela Ribeiro; Catarina M. Correia; Vera L. M. Silva; Clementina M. M. Santos; Artur M. S. Silva; et al. "A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function (2019): https://doi.org/10.1039/C9FO01298B.
    10.1039/C9FO01298B
  58. Rocha, Sónia; Sousa, Adelaide; Ribeiro, Daniela; Correia, Catarina M.; Silva, Vera L. M.; Santos, Clementina M. M.; Silva, Artur M. S.; et al. "Correction: A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes a-amylase and a-glucosidase by chalcone derivatives". Food & Function 10 9 (2019): 6203-6203. http://dx.doi.org/10.1039/c9fo90045d.
    10.1039/c9fo90045d
  59. Ribeiro, Daniela; Freitas, Marisa; Rocha, Sílvia; Lima, José; Carvalho, Félix; Fernandes, Eduarda. "Calcium Pathways in Human Neutrophils—The Extended Effects of Thapsigargin and ML-9". Cells 7 11 (2018): 204. http://dx.doi.org/10.3390/cells7110204.
    10.3390/cells7110204
  60. Rocha, Sonia; Ribeiro, Daniela; Fernandes, Eduarda; Freitas, Marisa (Corresponding author). "Systematic review on anti-diabetic properties of chalcones". Current Medicinal Chemistry 25 (2018): http://dx.doi.org/10.2174/0929867325666181001112226.
    10.2174/0929867325666181001112226
  61. Ribeiro, Daniela; Freitas, Marisa; Silva, Artur M.S.; Carvalho, Félix; Fernandes, Eduarda. "Antioxidant and pro-oxidant activities of carotenoids and their oxidation products". Food and Chemical Toxicology 120 (2018): 681-699. http://dx.doi.org/10.1016/j.fct.2018.07.060.
    10.1016/j.fct.2018.07.060
  62. Ribeiro, Daniela; Proenca, Carina; Rocha, Silvia; Lima, Jose L.F.C.; Carvalho, Felix; Fernandes, Eduarda; Freitas, Marisa (Corresponding author). "Immunomodulatory Effects of Flavonoids in the Prophylaxis and Treatment of Inflammatory Bowel Diseases: A Comprehensive Review". Current Medicinal Chemistry 25 28 (2018): 3374-3412. http://dx.doi.org/10.2174/0929867325666180214121734.
    10.2174/0929867325666180214121734
  63. Clementina M.M. Santos; Marisa Freitas; Eduarda Fernandes. "A comprehensive review on xanthone derivatives as alpha-glucosidase inhibitors". European Journal of Medicinal Chemistry 157 (2018): 1460-1479. https://doi.org/10.1016/j.ejmech.2018.07.073.
    10.1016/j.ejmech.2018.07.073
  64. Proença, C.; Freitas, M.; Ribeiro, D.; Sousa, J.L.C.; Carvalho, F.; Silva, A.M.S.; Fernandes, P.A.; Fernandes, E.. "Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study". Food and Chemical Toxicology 111 (2018): 474-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037682773&partnerID=MN8TOARS.
    10.1016/j.fct.2017.11.039
  65. Ribeiro, Daniela; Sousa, Adelaide; Rocha, Silvia; Freitas, Marisa; Fernandes, Eduarda. "beta-Carotene and its biological oxidation products: are they good modulators of pro-oxidant reactive species in human blood and neutrophils assay systems?". Free Radical Biology and Medicine (2018): https://publons.com/publon/19644506/.
    10.1016/J.FREERADBIOMED.2018.05.053
  66. Pimentel, Filipa B.; Costa, Anabela S. G.; Alves, Rita C.; Freitas, Marisa; Fernandes, Eduarda; Oliveira, M. Beatriz P. P.. "Nutritional and antioxidant screening of Gracilaria vermiculophylla". Annals of Medicine (2018): https://publons.com/wos-op/publon/19494498/.
  67. Daniela Rodrigues; Marisa Freitas; Vera Marisa Costa; Manuel Arturo Lopez-Quintela; José Rivas; Paulo Freitas; Félix Carvalho; Eduarda Fernandes; Paula Silva. "Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles". Nanotoxicology 11 2 (2017): 256-266. https://doi.org/10.1080/17435390.2017.1291865.
    10.1080/17435390.2017.1291865
  68. Guzmán-Guillén, Remedios; Campos, Alexandre; Machado, Joana; Freitas, Marisa; Azevedo, Joana; Pinto, Edgar; Almeida, Agostinho; Cameán, Ana M.; Vasconcelos, Vitor. "Effects of Chrysosporum (Aphanizomenon) ovalisporum extracts containing cylindrospermopsin on growth, photosynthetic capacity, and mineral content of carrots (Daucus carota)". Ecotoxicology 26 1 (2017): 22-31. http://dx.doi.org/10.1007/s10646-016-1737-4.
    10.1007/s10646-016-1737-4
  69. Boeing, J.S.; Ribeiro, D.; Chisté, R.C.; Visentainer, J.V.; Costa, V.M.; Freitas, M. (Corresponding author); Fernandes, E.. "Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress". Food Chemistry 220 (2017): 427-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991478616&partnerID=MN8TOARS.
    10.1016/j.foodchem.2016.09.188
  70. Proença, C.; Freitas, M.; Ribeiro, D.; Oliveira, E.F.T.; Sousa, J.L.C.; Tomé, S.M.; Ramos, M.J.; et al. "Alpha-glucosidase inhibition by flavonoids: an in vitro and in silico structure–activity relationship study". Journal of Enzyme Inhibition and Medicinal Chemistry 32 1 (2017): 1216-1228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029757909&partnerID=MN8TOARS.
    10.1080/14756366.2017.1368503
  71. Flórez, N.; González-Muñoz, M.J.; Ribeiro, D.; Fernandes, E.; Domínguez, H.; Freitas, M. (Corresponding author). "Algae polysaccharides' chemical characterization and their role in the inflammatory process". Current Medicinal Chemistry 24 2 (2017): 149-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012034485&partnerID=MN8TOARS.
    10.2174/092986732366616102
  72. Proença, C.; Ribeiro, D.; Soares, T.; Tomé, S.M.; Silva, A.M.S.; Lima, J.L.F.C.; Fernandes, E.; Freitas, M. (Corresponding author). "Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood". Inflammation 40 4 (2017): 1155-1165. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017415236&partnerID=MN8TOARS.
    10.1007/s10753-017-0559-8
  73. Chisté, R.C.; Ribeiro, D.; Freitas, M.; Leite, A.; Moniz, T.; Rangel, M.; Fernandes, E.. "Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties". Journal of Inorganic Biochemistry 155 (2016): 9-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947708390&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.11.009
  74. Kupski, L.; Freitas, M. (Corresponding author); Ribeiro, D.; Furlong, E.B.; Fernandes, E.. "Ochratoxin A activates neutrophils and kills these cells through necrosis, an effect eliminated through its conversion into ochratoxin a". Toxicology 368-369 (2016): 91-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987862424&partnerID=MN8TOARS.
    10.1016/j.tox.2016.09.001
  75. Proença, C.; Albuquerque, H.M.T.; Ribeiro, D.; Freitas, M.; Santos, C.M.M.; Silva, A.M.S.; Fernandes, E.. "Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 115 (2016): 381-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961962762&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.03.043
  76. Sousa, J.L.C.; Proença, C.; Freitas, M.; Fernandes, E.; Silva, A.M.S.. "New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 119 (2016): 250-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969872335&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.04.057
  77. Figueira, M.-E.; Oliveira, M.; Direito, R.; Rocha, J.; Alves, P.; Serra, A.-T.; Duarte, C.; et al. "Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat". Biomedicine and Pharmacotherapy 83 (2016): 1191-1202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989266756&partnerID=MN8TOARS.
    10.1016/j.biopha.2016.08.040
  78. Soares, T.; Ribeiro, D.; Proença, C.; Chisté, R.C.; Fernandes, E.; Freitas, M. (Corresponding author). "Size-dependent cytotoxicity of silver nanoparticles in human neutrophils assessed by multiple analytical approaches". Life Sciences 145 (2016): 247-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953293078&partnerID=MN8TOARS.
    10.1016/j.lfs.2015.12.046
  79. Tavares-da-Silva, E.J.; Varela, C.L.; Pires, A.S.; Encarnação, J.C.; Abrantes, A.M.; Botelho, M.F.; Carvalho, R.A.; et al. "Combined dual effect of modulation of human neutrophils’ oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives". Bioorganic and Medicinal Chemistry 24 16 (2016): 3556-3564. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973461690&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.05.065
  80. Couto, D.; Freitas, M.; Costa, V.M.; Chisté, R.C.; Almeida, A.; Lopez-Quintela, M.A.; Rivas, J.; et al. "Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity". Journal of Applied Toxicology 36 10 (2016): 1321-1331. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982946708&partnerID=MN8TOARS.
    10.1002/jat.3323
  81. Ribeiro, A.B.; Berto, A.; Chisté, R.C.; Freitas, M.; Visentainer, J.V.; Fernandes, E.. "Bioactive compounds and scavenging capacity of extracts from different parts of Vismia cauliflora against reactive oxygen and nitrogen species". Pharmaceutical Biology 53 9 (2015): 1267-1276. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940839512&partnerID=MN8TOARS.
    10.3109/13880209.2014.974063
  82. Chisté, R.C.; Freitas, M.; Mercadante, A.Z.; Fernandes, E.. "Superoxide anion radical: Generation and detection in cellular and non-cellular systems". Current Medicinal Chemistry 22 37 (2015): 4234-4256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953898004&partnerID=MN8TOARS.
    10.2174/0929867322666151029104311
  83. Ribeiro, A.B.; Berto, A.; Ribeiro, D.; Freitas, M. (Corresponding author); Chisté, R.C.; Visentainer, J.V.; Fernandes, E.. "Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes". Pharmaceutical Biology 53 11 (2015): 1691-1698. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945977356&partnerID=MN8TOARS.
    10.3109/13880209.2014.1001407
  84. Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C.M.; et al. "Anti-inflammatory effect of rosmarinic acid and an extract of rosmarinus officinalis in rat models of local and systemic inflammation". Basic and Clinical Pharmacology and Toxicology 116 5 (2015): 398-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926358222&partnerID=MN8TOARS.
    10.1111/bcpt.12335
  85. Couto, D.; Freitas, M.; Carvalho, F.; Fernandes, E.. "Iron oxide nanoparticles: An insight into their biomedical applications". Current Medicinal Chemistry 22 15 (2015): 1808-1828. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931275074&partnerID=MN8TOARS.
    10.2174/0929867322666150311151403
  86. Silva, S.; Sepodes, B.; Rocha, J.; Direito, R.; Fernandes, A.; Brites, D.; Freitas, M.; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis". Journal of Nutritional Biochemistry 26 4 (2015): 360-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925341472&partnerID=MN8TOARS.
    10.1016/j.jnutbio.2014.11.011
  87. Ribeiro, D.; Freitas, M.; Lima, J.L.F.C.; Fernandes, E.. "Proinflammatory Pathways: The Modulation by Flavonoids". Medicinal Research Reviews 35 5 (2015): 877-936. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938743566&partnerID=MN8TOARS.
    10.1002/med.21347
  88. Rocha, J.; Figueira, M.-E.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Inhibition of glycogen synthase kinase-3ß attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat". Shock 43 4 (2015): 369-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924905290&partnerID=MN8TOARS.
    10.1097/SHK.0000000000000298
  89. Ribeiro, D.; Freitas, M.; Tomé, S.M.; Silva, A.M.S.; Laufer, S.; Lima, J.L.F.C.; Fernandes, E.. "Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood". Inflammation 38 2 (2015): 858-870. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939895701&partnerID=MN8TOARS.
    10.1007/s10753-014-9995-x
  90. Gomes, A.; Capela, J.P.; Ribeiro, D.; Freitas, M.; Silva, A.M.S.; Pinto, D.C.G.A.; Santos, C.M.M.; et al. "Inhibition of NF-kB Activation and Cytokines Production in THP-1 Monocytes by 2-Styrylchromones". Medicinal Chemistry 11 6 (2015): 560-566. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938564231&partnerID=MN8TOARS.
    10.2174/1573406411666150209114702
  91. Alessandra Braga Ribeiro; Renan Campos Chisté; Marisa Freitas; Alex Fiori da Silva; Jesuí Vergílio Visentainer; Eduarda Fernandes. "Psidium cattleianum fruit extracts are efficient in vitro scavengers of physiologically relevant reactive oxygen and nitrogen species". Food Chemistry 165 (2014): 140-148. https://doi.org/10.1016%2Fj.foodchem.2014.05.079.
    10.1016/j.foodchem.2014.05.079
  92. Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat". Inflammation 38 1 (2014): 312-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964211290&partnerID=MN8TOARS.
    10.1007/s10753-014-0035-7
  93. Couto, D.; Freitas, M.; Vilas-Boas, V.; Dias, I.; Porto, G.; Lopez-Quintela, M.A.; Rivas, J.; et al. "Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils". Toxicology Letters 225 1 (2014): 57-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890396434&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.11.020
  94. Couto, D.; Freitas, M.; Porto, G.; Lopez-Quintela, M.A.; Rivas, J.; Freitas, P.; Carvalho, F.; Fernandes, E.. "Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways". Archives of Toxicology 89 10 (2014): 1759-1769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942195290&partnerID=MN8TOARS.
    10.1007/s00204-014-1325-4
  95. Pistón, M.; Machado, I.; Branco, C.S.; Cesio, V.; Heinzen, H.; Ribeiro, D.; Fernandes, E.; Chisté, R.C.; Freitas, M. (Corresponding author). "Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynara cardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS". Food Research International 64 (2014): 150-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903472873&partnerID=MN8TOARS.
    10.1016/j.foodres.2014.05.078
  96. Ribeiro, D.; Freitas, M.; Tomé, S.M.; Silva, A.M.S.; Porto, G.; Cabrita, E.J.; Marques, M.M.B.; Fernandes, E.. "Inhibition of LOX by flavonoids: A structure-activity relationship study". European Journal of Medicinal Chemistry 72 (2014): 137-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890960018&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.11.030
  97. Freitas, M. (Corresponding author); Ribeiro, D.; Tomé, S.M.; Silva, A.M.S.; Fernandes, E.. "Synthesis of chlorinated flavonoids with anti-inflammatory and pro-apoptotic activities in human neutrophils". European Journal of Medicinal Chemistry 86 (2014): 153-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906518198&partnerID=MN8TOARS.
    10.1016/j.ejmech.2014.08.035
  98. Figueira, M.E.; Câmara, M.B.; Direito, R.; Rocha, J.; Serra, A.T.; Duarte, C.M.M.; Fernandes, A.; et al. "Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis". Food and Function 5 12 (2014): 3241-3251. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912123071&partnerID=MN8TOARS.
    10.1039/c4fo00376d
  99. Chisté, R.C.; Freitas, M.; Mercadante, A.Z.; Fernandes, E.. "Carotenoids are Effective Inhibitors of in vitro Hemolysis of Human Erythrocytes, as Determined by a Practical and Optimized Cellular Antioxidant Assay". Journal of Food Science 79 9 (2014): H1841-H1847. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921910359&partnerID=MN8TOARS.
    10.1111/1750-3841.12580
  100. Chisté, R.C.; Freitas, M.; Mercadante, A.Z.; Fernandes, E.. "Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes". Life Sciences 99 1-2 (2014): 52-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896732745&partnerID=MN8TOARS.
    10.1016/j.lfs.2014.01.059
  101. Ribeiro, D.; Freitas, M. (Corresponding author); Tomé, S.M.; Silva, A.M.S.; Porto, G.; Fernandes, E.; Daniela Ribeiro; et al. "Modulation of human neutrophils' oxidative burst by flavonoids". European Journal of Medicinal Chemistry 67 (2013): 280-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882515383&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.06.019
  102. Freitas, M. (Corresponding author); Costa, V.M.; Ribeiro, D.; Couto, D.; Porto, G.; Carvalho, F.; Fernandes, E.; et al. "Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils". Toxicology Letters 219 2 (2013): 170-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876313471&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.03.007
  103. Chisté, R.C.; Freitas, M.; Mercadante, A.Z.; Fernandes, E.. "The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species". Food Chemistry 135 3 (2012): 1740-1749. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865765134&partnerID=MN8TOARS.
    10.1016/j.foodchem.2012.06.027
  104. Gomes, A.; Couto, D.; Alves, A.; Dias, I.; Freitas, M.; Porto, G.; Duarte, J.A.; Fernandes, E.. "Trihydroxyflavones with antioxidant and anti-inflammatory efficacy". BioFactors 38 5 (2012): 378-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867684223&partnerID=MN8TOARS.
    10.1002/biof.1033
  105. Estevão, M.S.; Carvalho, L.C.R.; Freitas, M.; Gomes, A.; Viegas, A.; Manso, J.; Erhardt, S.; et al. "Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening". European Journal of Medicinal Chemistry 54 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864416220&partnerID=MN8TOARS.
    10.1016/j.ejmech.2012.06.040
  106. Díaz, B.; Gomes, A.; Freitas, M.; Fernandes, E.; Nogueira, D.R.; González, J.; Moure, A.; et al. "Valuable Polyphenolic Antioxidants from Wine Vinasses". Food and Bioprocess Technology 5 7 (2012): 2708-2716. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867567058&partnerID=MN8TOARS.
    10.1007/s11947-011-0569-8
  107. Cabrita, A.R.J.; Maia, M.R.; Freitas, M.; Abreu, J.M.F.; Mira Fonseca, A.J.. "Colour score as a guide for estimating the protein value of corn gluten feed". Journal of the Science of Food and Agriculture 91 9 (2011): 1648-1652. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958730137&partnerID=MN8TOARS.
    10.1002/jsfa.4361
  108. Freitas, M.; Fernandes, E.. "Zinc, cadmium and nickel increase the activation of NF-kB and the release of cytokines from THP-1 monocytic cells". Metallomics 3 11 (2011): 1238-1243. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455163166&partnerID=MN8TOARS.
    10.1039/c1mt00050k
  109. Gomes, A.; Freitas, M.; Fernandes, E.; Lima, J.L.F.C.. "Biological activities of 2-styrylchromones". Mini-Reviews in Medicinal Chemistry 10 1 (2010): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951102947&partnerID=MN8TOARS.
    10.2174/138955710791112550
  110. Freitas, M.; Lima, J.L.F.C.; Porto, G.; Fernandes, E.. "Metal-induced oxidative burst in isolated human neutrophils". Microchemical Journal 96 1 (2010): 167-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955559263&partnerID=MN8TOARS.
    10.1016/j.microc.2010.03.002
  111. Santos, C.M.M.; Freitas, M.; Ribeiro, D.; Gomes, A.; Silva, A.M.S.; Cavaleiro, J.A.S.; Fernandes, E.. "2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure-activity relationship study". Bioorganic and Medicinal Chemistry 18 18 (2010): 6776-6784. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956342859&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.07.044
  112. Estevão, M.S.; Carvalho, L.C.; Ribeiro, D.; Couto, D.; Freitas, M.; Gomes, A.; Ferreira, L.M.; Fernandes, E.; Marques, M.M.B.. "Antioxidant activity of unexplored indole derivatives: Synthesis and screening". European Journal of Medicinal Chemistry 45 11 (2010): 4869-4878. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957850268&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.07.059
  113. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Zinc activates neutrophils' oxidative burst". BioMetals 23 1 (2010): 31-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949424370&partnerID=MN8TOARS.
    10.1007/s10534-009-9264-x
  114. Freitas, M.; Gomes, A.; Porto, G.; Fernandes, E.; Marisa Freitas (Presenter); Ana Gomes; Graça Porto; José L. F. C. Lima; Eduarda Fernandes. "Nickel induces oxidative burst, NF-kB activation and interleukin-8 production in human neutrophils". Journal of Biological Inorganic Chemistry 15 8 (2010): 1275-1283. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649960929&partnerID=MN8TOARS.
    10.1007/s00775-010-0685-3
  115. Couto, D.; Ribeiro, D.; Freitas, M.; Gomes, A.; Lima, J.L.F.C.; Fernandes, E.. "Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine". Redox Report 15 6 (2010): 259-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651112199&partnerID=MN8TOARS.
    10.1179/135100010X12826446921707
  116. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro". Talanta 78 4-5 (2009): 1476-1483. http://www.scopus.com/inward/record.url?eid=2-s2.0-63949083263&partnerID=MN8TOARS.
    10.1016/j.talanta.2009.02.050
  117. Gomes, A.; Neuwirth, O.; Freitas, M.; Couto, D.; Ribeiro, D.; Figueiredo, A.G.P.R.; Silva, A.M.S.; et al. "Synthesis and antioxidant properties of new chromone derivatives". Bioorganic and Medicinal Chemistry 17 20 (2009): 7218-7226. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749101847&partnerID=MN8TOARS.
    10.1016/j.bmc.2009.08.056
  118. Freitas, M.; Lima, J.L.F.C.; Fernandes, E.. "Optical probes for detection and quantification of neutrophils' oxidative burst. A review". Analytica Chimica Acta 649 1 (2009): 8-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-67949106472&partnerID=MN8TOARS.
    10.1016/j.aca.2009.06.063
  119. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Isolation and activation of human neutrophils in vitro. The importance of the anticoagulant used during blood collection". Clinical Biochemistry 41 7-8 (2008): 570-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-41949102130&partnerID=MN8TOARS.
    10.1016/j.clinbiochem.2007.12.021
Online resource
  1. Adelaide Sousa; Ana T. Rufino; Ana Ramalho; Félix Carvalho; Eduarda Fernandes; Freitas, Marisa. Corresponding author: Freitas, Marisa. Intestinal inflammation mediated by silver nanoparticles is prevented by dietary flavonoids. 2022. https://atlasofscience.org/intestinal-inflammation-mediated-by-silver-nanoparticles-is-prevented-by-dietary-flavonoids/.
  2. Freitas, Marisa; Carina Proença; Ana S. Pires; Elisiário Tavares-da Silva; Fernanda M. F. Roleira; Eduarda Fernandes. The complementary anti-inflammatory and anticancer activity of hydroxycinnamic acid derivatives. 2021. https://atlasofscience.org/the-complementary-anti-inflammatory-and-anticancer-activity-of-hydroxycinnamic-acid-derivatives/.
Thesis / Dissertation
  1. Freitas, Marisa. "The effect of metals on human neutrophils". PhD, Universidade do Porto Faculdade de Farmácia, 2010.
  2. Freitas, Marisa. "Estudo da activação de neutrófilos humanos pelo nitrato de níquel". Master, Universidade do Porto Faculdade de Farmácia, 2006.

Other

Other output
  1. COST CA20121- Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar). This Action will build a network of excellence for integrating and spreading the existing knowledge and providing innovative services, drugs and tools related to NRF2-pharmacology, with the final goal of boosting the translation to the European industry sector.. 2022. Freitas, Marisa.
  2. COST Action CA16119- In vitro 3D-total cell guidance and fitness. This Action aimed to refine the understanding of the in vivo microenvironment, reducing the differences when translating it in vitro, to create 3D total guidance ex vivo culture systems for the replacement of animal use.. 2017. Freitas, Marisa.
  3. COST Action CA15129- Diagnosis, Monitoring and Prevention of Exposure-Related Noncommunicable Diseases. This Action aims to develop an interdisciplinry collaborative network, providing insight into emerging issues of morbidity and mortality from exposure-related health outcomes. DiMoPEx aims to attract the interest of next generation early career investigators to the emerging issues of exposure-related disease burden and various aspects of exposure sciences.. 2016. Freitas, Marisa.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 Revealing the immunomodulatory potential of pyrazoles and exploring structure-activity relationships XXVII Encontro Luso-Galego de Química
(Portugal)
2023/11 Exploring the Modulatory Effects of Flavonoids and Pyrazoles in Hepatic Insulin Resistance and Glucose Metabolism in Non-Cellular and Cellular Models XXVII Encontro Luso-Galego de Química
(Portugal)
2023/11 Quercetin mitigates mouse intestinal inflammation induced by silver nanoparticles XXVII Encontro Luso-Galego de Química
(Portugal)
2023/11 Modulation of cytochrome P450 pathways by flavonoids: unravelling the CYP3A4 inhibition in metabolism XXVII Encontro Luso-Galego de Química
(Portugal)
2023/09 Glycogen phosphorylase inhibitory activity of structurally related polyphenols in an optimized microanalysis screening system 14th World Congress on Polyphenols Applications
(Malta)
2023/06 Unveiling the pro-inflammatory pathway of silver nanoparticles at the intestinal level Workshop Portugal-Brazil on Nanosciences and Nanotechnologies
International Iberian Nanotechnology Laboratory (Braga, Portugal)
2023/06 Exploring the potential of pyrazoles and flavonoids on emerging pharmacological liver targets for the treatment of diabetes 6th Symposium in Medicinal Chemistry
(Portugal)
2023/06 Dual-acting anti-inflammatory activity of pyrazoles through the inhibition of COX-2 and human leukocytes’ oxidative burst 6th Symposium in Medicinal Chemistry
2023/05 Pyrazoles as potential modulators of inflammation through the inhibition of COX-2 activity and human leukocytes’ oxidative burst 16º IJUP (Investigação Jovem na Universidade do Porto)
(Porto, Portugal)
2022/11/16 Flavonoids as potential anti-obesity compounds: Inhibition of pancreatic lipase XXVI Encontro Galego-Portugués de Química
(Spain)
2022/11/16 Size and coating-dependent toxicity of silver nanoparticles to human monocytes and macrophages XXVI Encontro Galego-Portugués de Química
(Spain)
2022/11/16 Flavonoids as effective inhibitors of type 2 diabetes target enzymes. A structure–activity relationship Symposium in Medicinal Chemistry
Universidade do Minho (Portugal)
2021/10/09 Efeito modulador das chalconas em modelos in vitro de diabetes melitus: papel da atividade antioxidante I Simpósio Internacional de Nutrição
(Maceió, Brazil)
2021/06/11 In vitro protective role of flavonoids against the harmful effects of silver nanoparticles in cells of the gastrointestinal tract. 2nd International Webinar on Chemistry and Pharmaceutical Chemistry-Online
2021/05 Silver nanoparticles activate neutrophils’ oxidative burst via a pathway inhibitable by flavonoids IJUP’14th Meeting of Young Researchers of University of Porto
2020/11/05 2-styrylchromones versus flavonoids: which have the best anti-inflammatory activity? IberPhenol International Conference
2020/01/15 Chalcones as modulators of neutrophils oxidative burst, in physiological and hyperglycemic conditions 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica
(Aveiro, Portugal)
2020/01/15 Inhibition of pancreatic a-amylase activity by a group of hydroxyxanthones 13º Encontro Nacional de Química Orgânica, 6º Encontro Nacional de Química Terapêutica
(Aveiro, Portugal)
2019/11/20 Synaptosomes as membranar models to study the effects of carotenoids on lipid peroxidation XXV Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2019/11/20 The potential antidiabetic effect of flavonoids through inhibition of fructose 1,6-bisphosphatase XXV Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2019/11 Chalcones as modulators of neutrophils’ oxidative burst, in physiological and hyperglycemic conditions XXV Encontro Galego-Portugués de Química
(Santiago de Compostela, Spain)
2019/10/11 Sangue total e neutrófilos humanos modelos in vitro para detecção de stress oxidativo V Simpósio Nordestino de Pós-Graduação em Química e Biotecnologia
Universidade Federal de Alagoas (Maceió, Brazil)
2019/10/09 Efeito modulador das chalconas em modelos in vitro de diabetes melitus: papel da atividade antioxidante I Simpósio Internacional de Nutrição
Universidade Federal de Alagoas (Maceió, Brazil)
2019/10 Sangue total e neutrófilos humanos modelos in vitro para detecção de stress oxidativo V Simpósio Nordestino de Pós-Graduação em Química e Biotecnologia
(Maceió, Brazil)
2019/06/17 Synthesis and in vitro a-glucosidase inhibitory activity of plolyhydroxylated 2-styrylchromones XVIII International Conference on Heterocycles in Bioorganic Chemistry
(Ghent, Belgium)
2019/02/06 The size and coating of silver nanoparticles differently affects in vitro human neutrophils’ oxidative burst, calcium levels and viability XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia
(Porto, Portugal)
2018/11/21 Chalcones as alpha-amylase and alpha-glucosidase inhibitors for the management of diabetes mellitus XXII Encontro Luso-Galego de Química
(Porto, Portugal)
2018/11/21 Evaluation of in vitro anti-diabetic potentital of 2,3-diarylxanthones through the inhibition of a-glucosidase Encontro Luso-Galego de Química
(Porto, Portugal)
2018/11/21 Development and application of a synaptosomal model for the study of peroxynitrite-induced lipid peroxidation Encontro Luso-Galego de Química
(Porto, Portugal)
2018/07/09 The interaction of silver nanoparticles with human neutrophils. Workshop: Interaction between nanomaterials and the immune system: medical exploitations and safety issues
(Milan, Italy)
2018/07/05 Potential pro-inflammatory hazzard of low size and citrate-coated silver nanoparticles for human neutrophils 12th Inorganic and Bioinorganic Chemistry Conference
(Porto, Portugal)
2017/10/12 Prediction of anti-diabetic activity of flavonoids targeting alpha-glucosidase 22th International Congress on Prevention of Diabetes and Complications
(London, United Kingdom)
2017/10/12 Structure-related inhibition of Protein Tyrosine Phosphatase 1B (PTP1B) by flavonoids 22th International Congress on Prevention of Diabetes and Complications
(London, United Kingdom)
2016/06/06 Assessment of human neutrophils’ viability by multiple analytical approaches 8th Meeting of Analytical Chemistry Division of the Portuguese Chemical Society
(Lisboa, Portugal)
2016/02/04 Iron oxide nanoparticles activate hepatic and splenic mononuclear phagocyte sysyem in mice XLVI Reunião da sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2015/12/01 Flavonoids’ effects in proinflammatory signaling systems: in vitro structure/activity studies Congresso de Química Orgânica e Química Terapêutica
(Porto, Portugal)
2015/11/18 Chlorinated flavonoids are more effective than their parent compounds in the modulation of neutrophils' oxidative burst and lifespan XXI Encontro Galego-Portugués de Química
(Pontevedra, Spain)
2015/11/18 The antioxidant activity of novel chromones and xanthones: a structure-activity relationship XXI Encontro Galego-Portugués de Química
(Pontevedra)
2014/11/26 Avaliação da toxicidade de nanopartículas de prata em neutrófilos humanos XX Encontro Luso-Galego de Química
(Porto, Portugal)
2014/11/26 Solanum diploconos: caracterização química e potencial captador de espécies reativas de nitrogénio XX Encontro Luso-Galego de Química
(Porto, Portugal)
2013/11/13 Carotenoids prevent lipid peroxidation in human erythrocytes indued in vitro by peroxyl radicals and tert-butyl hydroperoxide XIX Encontro Galego-Portugués de Química
(Vigo, Spain)
2013/11/13 Estudo de flavonoides como potenciais inibidores da enzima lipoxigenase. XIX Encontro Galego-Portugués de Química
(Vigo, Spain)
2013/11/13 Flavonóides clorados como potenciais moduladores do burst oxidativo de neutrófilos humanos XIX Encontro Galego-Portugués de Química
(Vigo, Spain)
2013/11/13 Efeito de nanopartículas de óxido de ferro na activação do burst oxidativo de neutrófilos e produção de citocinas XIX Encontro Galego-Portugués de Química
(Vigo, Spain)
2013/06/12 Luminescence probes: study of the modulatory effect of flavonoids on oxidative burst in human neutrophils XXIII Encontro Nacional da SPQ
(Aveiro, Portugal)
2013/06/12 Effect of acetaminophen in human neutrophils’ oxidative burst and lifespan in vitro XXIII Encontro Nacional da SPQ
2012/11/28 Flavonoids and inflammation: a structure – activity relationship study 3º Encontro Nacional de Química Terapêutica
(Aveiro, Portugal)
2012/02/22 Antioxidant activity mediated by non-steroidal anti-inflammatory drugs of the anthranilic acid chemical group 5th Meeting of Young Researchers of University of Porto
(Porto, Portugal)
2011/11/09 Flavonóides - modeladores do burst oxidativo de neutrófilos humanos XVII Encontro Galego-Portugués de Química
(Pontevedra, Spain)
2011/11/09 Indução da apoptose em neutrófilos por nanopartículas de óxido de ferro XVII Encontro Galego-Portugués de Química
(Pontevedra, Spain)
2011/07/03 Trihydroxyflavones with antioxidant and anti-inflammatory capacity XXII Encontro Nacional SPQ
(Braga, Portugal)
2011/07/03 Efeitos pró-inflamatórios do Ni(II) em neutrófilos humanos XXII Encontro Nacional SPQ
(Braga, Portugal)
2011/07/03 Inhibition of human neutrophil oxidative burst mediated by flavonoids XXII Encontro Nacional SPQ
(Braga, Portugal)
2011/02/17 Modulation of human neutrophil oxidative burst by 3-hydroxyflavones 4th Meeting of Young Researchers of University of Oporto
(Porto, Portugal)
2010/11/10 Harmonização de condições experimentais para a detecção do “burst” oxidativo em neutrófilos humanos XVI Encontro Luso-Galego de Química, Aveiro
(Aveiro, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/02 - Current Exploring the Effects of Paraben Exposure on Key Metabolic Pathways in Diabesity: A Multi-Cellular Approach
Supervisor of Ana Patrícia Corunha Lei Barreiros Ramalho
REQUIMTE, Universidade do Porto, Faculdade de Farmácia, Portugal
2023/02 - Current Efeito protetor da quercetina na produção de óxido nítrico por células intestinais tratadas com nanopartículas de prata
Supervisor of Inês Alexandre Santos
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/03/01 - Current Phosphoglycoglycerol from Nature as model to new putative therapeutic agents
Co-supervisor
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/03 - Current Phosphoglycoglycerol from Nature as model to new putative therapeutic agentes
Co-supervisor of Luís Pedro Serra Pinheiro
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/01 - Current Use of flavonoids in the prophylaxis of intestinal pro-inflammatory effects of silver nanoparticles
Supervisor of Adelaide Patrícia Teles de Sousa
 Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/02 - Current Flavonoids loaded nanocarriers as an approach to increase their bioefficacy against Diabetes mellitus
Supervisor
 Pharmaceutical Sciences (PhD)
REQUIMTE, Universidade do Porto, Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/09 - Current Chalcones targeting neutrophils to treat diabetes mellitus
Supervisor of Adelaide Patrícia Teles de Sousa
 Quality Control (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/09 - 2023/11 Flavonoides como moduladores da diabetes tipo 2 através da inibição das enzimas a-amilase and a-glucosidase
Co-supervisor of Edite Ferreira Pinto
Universidade do Porto Faculdade de Ciências, Portugal
2022/09 - 2023/10 Pyrazoles modulate the inflammatory process through the inhibition of COX-2 activity and leukocytes’ oxidative burst
Supervisor of Jorge Miguel Almeida Silva
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2022/07 - 2022/09 Polyphenols as potential inhibitors of pancreatic lipase
Co-supervisor of Álvaro Tomé Nieto
Universidad de la Rioja, Spain
2022/02 - 2022/08 Avaliação da inibição da enzima a-glucosidase por flavonoides
Co-supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
2022/07 - 2022/07 Efeitos biológicos de polifenois
Co-supervisor of Ana Margarida Pereira da Silva
Universidade do Porto Faculdade de Farmácia, Portugal
2022/02 - 2022/07 Biodistribuição de nanopartículas de prata e o seu efeito na viabilidade de células intestinais
Supervisor of Ariana Raquel Pinto Gomes
Universidade do Porto Faculdade de Engenharia, Portugal
2021/09 - 2022/02 Atividade inibitória da enzima alfa-glucosidase por estirilcromonas e estirilpirazóis
Co-supervisor
 Pharmaceutical Sciences (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/09 - 2022/02 Atividade inibitória da enzima a-glucosidase por estirilcromonas e estirilpirazóis
Co-supervisor of Joana Maria Carvalho Correia
Universidade do Porto Faculdade de Farmácia, Portugal
2021/02 - 2021/07 Efeito protetor de flavonoides em neutrófilos tratados com nanopartículas de prata
Supervisor of Jorge Miguel Almeida Silva
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02 - 2021/07 Efeito da fisetina no processo apoptótico em esferoides de osteossarcoma humano
Co-supervisor
 Biology (Degree)
Faculty of Sciences of University of Porto, Portugal
2021/02 - 2021/06 Efeito da fisetina no processo apoptótico em esferoides de osteossarcoma humano
Co-supervisor of Raquel Alexandra Martins Santos
Universidade do Porto Faculdade de Ciências, Portugal
2020/01/01 - 2020/07 Avaliação do efeito de nanopartículas no burst oxidativo de neutrófilos humanos
Supervisor of Ana Patrícia Corunha Lei Barreiros Ramalho
 Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2019/11 Chalcones targeting neutrophils for the modulation of oxidative stress in physiological and hyperglycemic conditions. Potential application in the treatment of diabetes mellitus
Supervisor
 Quality control (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/09 - 2019/09 Assessment of pro-inflammatory effects of silver nanoparticles in intestinal in vitro models, and development of protective strategies using anti-inflammatory flavonoids
Supervisor of Tânia Sofia Soares Couto
 Pharmaceuticals Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/02 - 2019/09 Otimização das condições experimentais do ensaio de inibição enzimática da alfa-amílase
Supervisor of Maria do Rosário Marques de Queirós Rodrigues
 Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/07 Estudo comparativo da citotoxicidade das nanopartículas de prata num modelo celular do epitélio intestinal
Supervisor of Miguel Tavares Lacerda
 Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2016/09 - 2018/11 Inhibitory activity of chalcones on key digestive enzymes for the management of Diabetes mellitus
Supervisor of Sónia Aguiar da Rocha
 Quality Control (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/02 - 2018/07 Flavonoids as modulators of Diabetes mellitus
Supervisor of Marta Isabel Araújo da Silva
 Pharmaceutical Sciences (Scientific initiation)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/02 - 2017/07 Inibição da alfa-glicosidase por flavonoides
Supervisor of Adelaide Patrícia Teles de Sousa
 Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/02 - 2017/07 The effect of chalcones on human neutrophils’ oxidative burst
Supervisor of Valéria Fabríciová
 Pharmaceutical Sciences- Erasmus Programme (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/06 - 2016/08 Avaliação da capacidade antioxidante contra espécies reativas de oxigênio e nitrogênio de extratos de Curcuma longa e constituintes isolados
Supervisor of Fabiana Oliveira dos Santos Camatari
 Chemistry and Biotechnology (PhD)
Universidade Federal de Alagoas, Brazil

Universidade do Porto Faculdade de Farmácia, Portugal
2016/02 - 2016/07 Antioxidant effect of resveratrol compared with their metabolites against H2O2-induced oxidative stress in Caco-2 cells
Co-supervisor of Sandra Isabel Pinto Nunes
 Biochemistry (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2014/10 Efeito das nanopartículas de prata em neutrófilos humanos
Supervisor of Tânia Sofia Couto Soares
 Quality Control (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2012/09 - 2014/06 Efeito da fluoxetina no desenvolvimento de formas imaturas de Calliphora vicina (Diptera: Calliphoridae)
Supervisor of Isa Dias
 Forensic Sciences and Laboratory Tecniques (Master)
Institute of Health Sciences (CESPU), Portugal
2012/03 - 2012/06 Estudo do efeito de pós de revelação de impressões digitais no stress oxidativo de neutrófilos humanos
Supervisor of Mariana Semedo
 Forensic Sciences (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/04/01 - 2011/06/30 Flavonoids with potential anti-inflammatory activity in vitro evaluation of their effects in pro-inflammatory signaling systems
Supervisor of Michaela Kohlová
 Pharmaceutical Sciences- Erasmus Programme (Degree)
Universidade do Porto Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/01/14 - 2022/01/14 Molecules' Webinar- “Polyphenols as a Therapeutic Option for the Treatment of Diabetes (2022/01/14 - 2022/01/14)
Conference (Member of the Organising Committee)
2021/06/25 - 2021/06/25 Cells' Webinar- The Interaction of Biomedical Nanoparticles with the Immune System (2021/06/25 - 2021/06/25)
Conference (Member of the Organising Committee)
2021/05/31 - 2021/05/31 Molecules' Webinar- New Trends of Flavonoids in Human Health (2021/05/31 - 2021/05/31)
Conference (Member of the Organising Committee)
2019/10/14 - 2019/10/17 Invited Professor of a course with theoretical and practical part under the theme "Deteção do stress oxidativo em modelos celulares e não celulares" (2019/10/14 - 2020/10/17)
Workshop (Co-organisor)
 Federal University of Alagoas, Brazil
2019/07/08 - 2019/07/12 “Universidade Júnior” program of Porto University in the project: "O admirável mundo da inflamação". (2019/07/08 - 2019/07/12)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018/11/01 - 2019/02/08 XLIX Meeting of the Portuguese Society of Pharmacology, XXXVII Meeting of Clinical Pharmacology and XVIII Meeting of Toxicology (2019/02/06 - 2019/02/08)
Meeting (Member of the Organising Committee)
 University of Porto, Faculty of Pharmacy, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/01/14 - Current Moderator in Molecules Webinar- "Polyphenols as a Therapeutic Option for the Treatment of Diabetes"
Seminar
 Molecules Webinar- Polyphenols as a Therapeutic Option for the Treatment of Diabetes
2021/06/25 - Current Moderator in Cells Webinar- "The Interaction of Biomedical Nanoparticles with the Immune System"
Seminar
 Cells Webinar- The Interaction of Biomedical Nanoparticles with the Immune System
2021/05/31 - Current Moderator in a Molecules Webinar- "New Trends of Flavonoids in Human Health"
Seminar
 Molecules Webinar- New Trends of Flavonoids in Human Health
2022/04/20 - 2022/04/22 Moderator in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
Congress
 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting
2021/05/05 - 2021/05/07 Moderator in 14º Encontro de Investigação Jovem da Universidade do Porto
Conference
 14º Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto, Portugal
2018/04/12 - 2018/04/15 Participation as REQUIMTE representant
Exhibition
 XVI Mostra de Iniciação Científica, Pós-graduação, Pesquisa e Extensão
Universidade do Porto, Portugal
2017/10/12 - 2017/10/13 Moderator in 22nd International Conference on Prevention of Diabetes and Complications (Pancreatic Disorders and Therapy)
Conference
 22nd International Conference on Prevention of Diabetes and Complications (Pancreatic Disorders and Therapy)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/10 Seminário de PhD: Design and synthesis of anti-inflammatory drugs based on cinnamic acid derivatives targeting COX-2
(Thesis) Main arguer
 João Luís Sousa Janela (Other)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/10 Pyrazoles modulate the inflammatory process through the inhibition of COX-2 activity and leukocytes’ oxidative burst
Supervisor
 Jorge Miguel Almeida Silva (Master)
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2023/07/23 Suplementação com extrato de curcumina e piperina em pacientes com doença inflamatória intestinal: um ensaio clínico randomizado, duplo cego, controlado por placebo
(Thesis) Main arguer
 Amylly Sanuelly da Paz Martins (PhD)
Universidade Federal de Alagoas, Brazil
2023/07 Solanum betaceusm Cav leaves: chemical composition and multimodal effect in the management of inflammatory events and on targets underlyng metabolic changes in diabetes
(Thesis) Main arguer
 Raquel Santos Martins (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/07 An In Vitro Chemobrain Study Focusing on New and Old Anticancer Drugs
(Thesis) Main arguer
 Maria Beatriz Igreja Cardoso (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/07 Efeito Antioxidante e Antidiabético de Compostos Fenólicos: Um Estudo de Relação Estrutura-Atividade
(Thesis) Main arguer
 Diogo Rodrigues Cortez Rebelo Carneiro (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/07 Avaliação do efeito de nanopartículas de prata e o potencial protetor da quercetina em células intestinais
Supervisor
 Inês Alexandre Santos (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/10/27 Caracterização de biomarcadores inflamatórios e de desequilíbrio redox em cordões umbilicais de gestações com pré-eclâmpsia
(Thesis) Main arguer
 Marilene Brandão Tenório Fragoso (PhD)
Universidade Federal de Alagoas, Brazil
2022/08/18 Efeito da suplementação do extrato de cúrcuma longa e piperina sobre os biomarcadores inflamatórios, estresse oxidativo e atividade antioxidante em pacientes com doença inflamatória intestinal atendidos em um Hospital Escola
(Thesis) Main arguer
 Amylly Sanuelly da Paz Martins (PhD)
Universidade Federal de Alagoas, Brazil
2022/07 Targeting pancreatic lipase for obesity treatment
(Thesis) Main arguer
 Sílvia Daniela Gonçalves da Rocha (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/07 GLP-1 analogues and leptin sensitizers as new anti-obesity approaches: The role of polyphenols for sustainable weight loss
(Thesis) Main arguer
 Maria Carolina Ribeiro Marujo e Rocha Lobo (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/02 Atividade inibitória da enzima a-glucosidase por estirilcromonas e estirilpirazóis
Thesis Member
 Joana Maria Carvalho Correia (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/02 Atividade inibitória da enzima a-glucosidase por estirilcromonas e estirilpirazóis
(Thesis) Main arguer
 Joana Maria Carvalho Correia (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/12 (E) -2-Estirilcromonas - Síntese e Avaliação dos Efeitos Inibitórios no Burst Oxidativo Produzido por Monócitos Humanos
(Thesis) Main arguer
 Catarina Marçal Correia (Master)
Universidade de Aveiro, Portugal
2021/10 In Vitro Toxicity Assessment of Metal Nanoparticles in Intestinal and Placental Cells
(Thesis) Main arguer
 Joana Maria Araújo Pires (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07 Efeito protetor de flavonoides em neutrófilos ativados por nanopartículas de prata
Supervisor
 Jorge Miguel Almeida Silva (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07 The long-term toxicity of doxorubicin: in vivo studies in adult mice
(Thesis) Main arguer
 Maria Francisca Tavares Brochado Teixeira Espincho (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07 Pesquisa de novas moléculas com atividade anti-inflamatória
(Thesis) Main arguer
 Ricardo Manuel Tavares Monteiro (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/06 Pro-inflammatory effects of silver nanoparticles in the intestine
Supervisor
 Adelaide Patrícia Teles de Sousa (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/04 Assessment of the antidiabetic activity of flavonoids: targeting key enzymes involved in type 2 diabetes pathophysiology
Thesis Member
 Carina Isabel Coelho Proença (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/03 Styrylchromones as privileged bioactive scaffolds: a review
(Thesis) Main arguer
 Mariana Filipa Mendes Lucas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/02 (E)-2-Styrylchromones: Antioxidant and anti-inflammatory activities and synthetic methods
(Thesis) Main arguer
 Catarina Marçal Correia (PhD)
Universidade de Aveiro, Portugal
2020/07 Avaliação do efeito de nanopartículas de prata no burst oxidativo de neutrófilos humanos
Supervisor
 Ana Patrícia Corunha Lei Barreiros Ramalho (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07 The therapeutic potential of 2-styrylchromones
(Thesis) Main arguer
 Melissa Martins Teixeira (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07 The neurotoxicity of catecholamines and in vitro studies for its evaluation
(Thesis) Main arguer
 Mónica Isabel Amorim Marques (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/06 Nano-based drug delivery systems used as vehicles of polyphenols for diabetes mellitus treatment
Supervisor
 Sónia Aguiar da Rocha (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/11 Chalcones targeting neutrophils for the modulation of oxidative stress in physiological and hyperglycemic conditions. Potential application in the treatment of Diabetes mellitus
Supervisor
 Adelaide Patrícia Teles de Sousa (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/09 Optimização das condições experimentais do ensaio de inibição da alfa-amilase
Supervisor
 Maria do Rosário Marques de Queirós Rodrigues Salcedas (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2019/07 Safety assessment of nanomaterials in a systems toxicology context
(Thesis) Main arguer
 Mariana Machado Pereira (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/07 Estudo comparativo da citotoxicidade das nanopartículas de prata num modelo celular do epitélio intestinal
Supervisor
 Miguel Tavares Lacerda (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2019/07 Role of non-nutritional sweeteners on the development and progression of chronic inflammatory diseases
(Thesis) Main arguer
 André Miguel Dias (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2019/02 Efeito dos carotenoides da dieta na peroxidação lipídica induzida pelo anião peroxinitrito
(Thesis) Main arguer
 Marta Isabel Araújo da Silva (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/12 Diabetes mellitus and oxidative stress: the protective role of chalcones
Supervisor
 Adelaide Patrícia Teles de Sousa (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/11 In vitro evaluation pf antidotes for Amanita phalloides intoxications
(Thesis) Main arguer
 Daniela Ferreira Rodrigues (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/11 Inhibitory activity of chalcones on key digestive enzymes for the management of Diabetes mellitus
Supervisor
 Sónia Aguiar da Rocha (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/07 Modulação da produção de mediadores inflamatórios pelas chalconas
(Thesis) Main arguer
 Thaise da Silva Martins (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/07 Desenvolvimento de um modelo em sinaptossomas para o estudo da peroxidação lipídica induzida pelo anião peroxinitrito
(Thesis) Main arguer
 Pedro Daniel Maia Nicola (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2018/07 Modulação da produção de mediadores inflamatórios pelas chalconas
(Thesis) Main arguer
 Thaise da Silva Martins (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/11 Estimation of Postmortem Interval Based on Cell Death Progression in Biological Fluids
(Thesis) Main arguer
 Mónica Cristina Francisco Tomé (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/09 Extraction and purification of antioxidant fractions from foreign species
(Thesis) Main arguer
 Maria Parada Casas (PhD)
Universidade de Vigo - Campus Ourense, Spain
2017/07 Inibição da alfa-glicosidase por flavonoides: relação estrutura-atividade
(Thesis) Main arguer
 Carina Isabel Coelho Proença (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/07 Inibição da enzima alfa-glicosidase por flavonoides
Supervisor
 Adelaide Patrícia Teles de Sousa (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/07 Inibição da a-glicosidase por flavonoides: relação estrutura-atividade
(Thesis) Main arguer
 Carina Isabel Coelho Proença (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/07 Resveratrol effects in H2O2-induced oxidative stress in Caco-2 cells
Supervisor
 Sandra Isabel Pinto Nunes (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2015/06 Avaliação da toxicidade da mitoxantrona num modelo de células neuronais SH-SY5Y
(Thesis) Main arguer
 Verónica Silva Correia (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2014/12 Flavonoids with potential anti-inflammatory activity: in vitro structure / activity studies of their effects in pro-inflammatory signaling systems
Thesis Member
 Daniela Sofia Almeida Ribeiro (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/10 Efeito das nanopartículas de prata em neutrófilos humanos
Supervisor
 Tânia Sofia Couto Soares (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/09 Atividade antioxidante de xantonas
(Thesis) Main arguer
 Carina Isabel Coelho Proença (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/06 Efeito da fluoxetina no desenvolvimento de formas imaturas de Calliphora vicina (Diptera: Calliphoridae)
Supervisor
 Isa Dias (Master)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2013/07 Atividades biológicas de 2-estirilcromonas
(Thesis) Main arguer
 Mara Sofia Fernandes (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/06 Nanopartículas de Prata: Aplicações e Toxicidade
Supervisor
 Tânia Sofia Couto Soares (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2012/06 Estudo do efeito de pós de revelação de impressões digitais no stress oxidativo de neutrófilos humanos
Supervisor
 Mariana Semedo (Other)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/09 Avaliação da actividade antioxidante do extrato de Castanea Sativa em queratinócitos humanos
(Thesis) Main arguer
 Raquel Giacomelli Saffi (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/09 Aplications and Toxicity of Iron Oxide Nanoparticles
(Thesis) Main arguer
 Rita Furtado Feio Azevedo (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/07 Avaliação da actividade antioxidante de flavonoids
(Thesis) Main arguer
 Andreia Filipa Barbosa Alves (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/06 Stress oxidativo cutâneo: metodologias de detecção e de avaliação da actividade antioxidante
(Thesis) Main arguer
 Raquel Giacomeli Saffi (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Consulting

Activity description Institution / Organization
2018/11 - Current Contribution, as Collaborator, in the “Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study” Collaborator in the GBD process, which is an approach to global descriptive epidemiology. Participation by providing feedback on the validity and interpretation of preliminary results before they are finalized for the estimation cycle and commenting on drafts of the GBD capstone publications the indexed international journal The Lancet with a focus on the presentation, discussion, and implications of key results. Institute for Health Metrics and Evaluation, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02 - Current Invited Professor in the Curricular Unit "Métodos Instrumentais de Análise II" Pharmaceutical Sciences (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2021/05/27 - Current Invited Professor in the course "Principles of Drug Design, Synthesis and Structure-Activity Relationships in Medicinal Chemistry" under the theme "Evaluation of a flavonoids library for inhibition of enzymes involved in Diabetes Mellitus pathophysiology towards a structure–activity relationship". Pharmaceutical Sciences (Mestrado integrado) Universidade de Coimbra, Portugal
2022/12/13 - 2023/01/06 Coordinator of the Course: "Citometria de Fluxo: dos princípios básicos às aplicações práticas " Citometria de Fluxo: dos princípios básicos às aplicações práticas (Outros) REQUIMTE, Universidade do Porto, Faculdade de Farmácia, Portugal
2020/09 - 2021/02 Invited Professor in the Curricular Unit "Métodos Instrumentais de Análise" Mestrado Toxicologia Analítica Clínica e Forense (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2020/11 - 2020/11 Invited Professor in the course Special Topics in Food and Nutrition under the theme "Finding the biological activities of flavonoids". (Postgraduate Certificate) Universidade Estadual de Campinas, Brazil
2019/10/14 - 2019/10/18 Detection of oxidative stress in cellular and non-cellular models Post-Graduation Programm in Chemistry and Biotecnology (Curso de doutoramento (conclusão de unidades curriculares)) Federal University of Alagoas, Brazil
2019/07/08 - 2019/07/12 "Universidade Júnior”- O admirável mundo da inflamação. (Ensino secundário) Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2019 Collaborator in the Curricular Unit "Métodos Instrumentais de Análise" Quality Control (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2019 Collaborator in the Curricular Unit "Controlo Toxicológico" Quality Control (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2017 Collaborator in the Curricular Unit "Métodos Instrumentais de Análise" Analytical and Clinical Forensic Toxicology (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2015 Collaborator in the Curricular Unit "Métodos de Análise Instrumental Aplicados à Farmacologia" Experimental and Clinical Farmacology and Toxicology (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Responsible for the curricular unit "Armas de Fogo e Projécteis" Forensic Sciences and Laboratory Tecnhiques (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011 - 2012 Responsible for the Curricular Unit "Investigação Criminal e Forense II" Forensic Sciences (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011 - 2012 Responsible for the Curricular Unit "Métodos de Recolha de Amostras e Vestígios Forenses" Forensic Sciences (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022/05/04 - 2022/05/05 Evaluator of Poster communications in "15ª Edição do Encontro Investigação Jovem"
Evaluator
 Universidade do Porto, Portugal
2020/02/12 - 2020/02/14 Evaluator of Oral communications in "13ª Edição de Encontro Jovem Investigação Jovem"
Evaluator
 Universidade do Porto, Portugal
2019/10/08 - 2019/10/11 Evaluator of Poster communications in "V Simpósio Nordestino of Pós-Graduação em Química e Biotecnologia"
Evaluator
 Federal University of Alagoas, Brazil
2019/10/08 - 2019/10/11 Evaluator of Oral communications in "V Simpósio Nordestino of Pós-Graduação em Química e Biotecnologia"
Evaluator
 Federal University of Alagoas, Brazil

Journal scientific committee

Journal title (ISSN) Publisher
2019/02/06 - Current Brazilian Journal of Pharmaceutical Sciences (1984-8250) SciELO
2019/02/01 - Current Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi
2019/02/01 - Current Frontiers in Physiology (1664-042X) Frontiers Media SA
2018/12/01 - Current Cells (ISSN 2073-4409) MDPI AG

Mentoring / Tutoring

Topic Student name
2019/09/01 - Current Antioxidant activity of natural compounds Mariana Lucas
2019/03 - 2021/08 Antidiabetic activity of flavonoids Ana Rufino
2017/03/06 - 2021/04 Development of new anti-diabetic drugs based on the flavonoid scaffold: interdisciplinary network of in silico, in vitro, in vivo and organic synthesis studies Carina Isabel Coelho Proença
2019/05/01 - 2019/05/15 "Técnicas de laboratório relacionadas à avaliação/quantificação de marcadores do estresse oxidativo e de inflamação" Jadriane de Almeida Xavier
2019/05/01 - 2019/05/15 "Técnicas de laboratório relacionadas à avaliação/quantificação de marcadores do estresse oxidativo e de inflamação" Fabiana Andrea Moura
2015/03 - 2016/01 Chemical characterization and antioxidant capacity of extracts obtained from Brazilian fruits Joana Schuelter Boeing
2015/03 - 2015/11 Scavenging capacity of extracts of Brazilian fruits against reactive oxygen (ROS) and nitrogen species (RNS) Érica Oliveira Barizão
2015/06 - 2015/07 The antioxidant properties of extracts of artichoke (Cynara scolymus) from Uruguay Mariela Mónica Pistón Pedreira
2015/05 - 2015/07 Extraction and isolation of bioactive compounds from Sargassum muticum Noelia Flórez Fernández
2015/05 - 2015/07 Anti-inflammatory activity of bioactive compounds isolated from Sargassum muticum María Parada Casas
2011/04 - 2015/07 Effects of paramagnetic and superparamagnetic iron oxide nanoparticles on human leukocytes Diana Manuel Mocho de Bastos Couto
2014/07 - 2015/04 Evaluation of the effects of ochratoxin A and its metabolites in human neutrophils and erythrocytes Larine Kupski
2014/06 - 2015/03 Avaliação do potencial antioxidante e determinação dos compostos bioativos de frutas nativas brasileiras não-exploradas Alessandra Braga Ribeiro
2014/07 - 2014/12 Chemical characterization and antioxidant activity of extracts from Amazonian fruits Alessandra Berto
2011/04 - 2014/09 Flavonoids with potential anti-inflammatory activity: in vitro structure/activity studies of their effects in pro-inflammatory signalling systems Daniela Sofia Almeida Ribeiro
2009/01 - 2014/05 Design, sinthesis and in vitro evaluation of novel cyclooxigenase-2 inhibitors Mónica Alexandra da Silva Estevão
2013/06 - 2014/02 Avaliação, in vitro, da actividade antioxidante de frutas nativas do Brasil Alessandra Braga Ribeiro
2012/05 - 2013/04 Development and validation of methodologies to determine the scavenging capacity of carotenoids against reactive oxygen and nitrogen species Renan Campos Chisté
2012/02 - 2012/03 Screening of anti-inflammatory potential in natural extracts Enma Conde Piñeiro
2011/05 - 2011/07 Estudo da actividade antioxidante de extractos de piquiá (Caryocar Villosum) Renan Campos Chisté
2010/09 - 2011/01 Avaliação da actividade antioxidante de flavonoides Andreia Filipa Barbosa Alves
2010/01 - 2011/01 Flavonoids with potential anti-inflammatory activity: In vitro evaluation of their effects in proinflammatory signalling systems Irene Leonor Moutinho Dias
2009/01 - 2010/01 COX/LOX Dual activity – A novel and rational approach towards inflammation Daniela Sofia Almeida Ribeiro
2008/11 - 2009/11 In vitro screening evaluation of antioxidant properties of chromones Andreia Filipa Barbosa Alves
2008/01 - 2009/11 In vitro screening evaluation of anti-inflammatory properties of novel indole derivatives Diana Patrícia Pereira da Costa
2008/10 - 2009/01 Scavenging activity for ROS and RNS by novel styrylchromones with potential antioxidant activity Ondrej Neuwirth
2008/09 - 2009/01 Avaliação da actividade captadora de espécies reactivas de oxigénio por agentes anti-inflamatórios não esteróides Daniela Sofia Almeida Ribeiro
2008/09 - 2009/01 Implementação de metodologias para avaliação da actividade captadora de ácido hipocloroso em leitor de placas Diana Manuel Mocho de Bastos Couto

Other jury / evaluation

Activity description Institution / Organization
2020/12 - Current Jury member in a public tender for a Research fellowship (Reference 2019-103) at the Associated Laboratory for Green Chemistry financed by National Funds through FCT / MCTES and considering the UID's Pluriannual funding (2020-2023). Universidade do Porto Faculdade de Farmácia, Portugal
2019/07 - Current Jury member in a public tender for a Research fellowship (Ref. ICETA 2019-62), under the project PTDC/QEQ-QAN/1742/2014, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/05 - Current Jury member in a public tender for Master's Research fellowship (Ref. ICETA 2019-41), under the project PTDC/QEQ-QAN/1742/2014, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/01 - Current Jury member in a public tender for an Assistant Researcher contract (REQUIMTE 2018-42), within the framework of a project, PTDC/NAN-MAT/29248/2017, financed by national funds through FCT / MCTES and the FEDER, through the COMPETE-Operational Competitiveness Factors Program (POFC) POFC-POCI-01-0145-FEDER-029248. Universidade do Porto Faculdade de Farmácia, Portugal
2018/09 - Current Jury member in a public tender for an Assistant Researcher contract (REQUIMTE 2018-13), within the framework of a project, PTDC/MED-QUI/29253/2017, financed by national funds through FCT/MCTES and the FEDER, through the COMPETE-Competitiveness Factors Operational Program (POFC) POFC-POCI-01-0145-FEDER-029253. Universidade do Porto Faculdade de Farmácia, Portugal
2016/09 - Current Jury member in a public tender for a Research Fellowship (Reference ICETA 2016-65), with the financial support of FCT/MEC through national funds and when applicable co-financed by the FEDER, POCI -01-0145-FEDER-007728, under the Partnership Agreement PT2020 Universidade do Porto Faculdade de Farmácia, Portugal
2016/06 - Current Jury member in a public tender for a Post-doctoral fellowship (ICETA 2016-40), within the framework of the project with the reference FCT PTDC/QEQ-QAN/1742/2014 and reference COMPETE POCI- 01-0145-FEDER-016530, financed by State Budget and FEDER, respectively. Universidade do Porto Faculdade de Farmácia, Portugal
2016/03 - Current Jury member in a public tender for a Master's Research fellowship (Ref. ICETA 2016-03), under the project UID / MULTI / 04378, with the financial support of FCT/MEC through national funds and when applicable co-financed by the FEDER under the Partnership Agreement PT2020 Universidade do Porto Faculdade de Farmácia, Portugal
2016/03 - Current Jury member in a public tender for a Post-doctoral fellowship (Ref. ICETA 2016-02), under the project UID / MULTI / 04378, with the financial support of FCT/MEC through national funds and when applicable co-financed by the FEDER under the Partnership Agreement PT2020 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - Current Peer-reviewer in several Journals: - Bioorganic chemistry - BMC Complementary & Alternative Medicine - BMC Research - Brazilian Journal of Pharmaceutical Sciences - Chemistry Biodiversity - Chemistry Central Journal - European Journal of Medicinal Chemistry - Food Bioscience - Food Research International - International Journal of Molecular Sciences - Journal of Chemistry - Journal of Functional Food - Molecules - Oxidative Medicine and Cellular Longevity - Plants - Scientific Reports - Toxicology In Vitro
Distinctions

Award

2020 Best Conference Oral Communication in Iberphenol International Conference, Online.
2018 Best Conference Poster at Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry, MedChemSicily, Palermo-Italy
European Federation for Medicinal Chemistry, Italy
2005 Merit Scholarship
Universidade do Porto, Portugal
2005 Merit Scholarship
Fundação Engenheiro António de Almeida, Portugal

Other distinction

2018 SFRR-Europe travel award