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Ana Rosa Soares. Completed the Doutoramento in Envelhecimento e Doenças Crónicas in 2019 by Universidade Nova de Lisboa Faculdade de Ciências Médicas, Doutoramento in Envelhecimento e Doenças Crónicas in 2019 by Universidade do Minho Escola de Medicina, Doutoramento in Envelhecimento e Doenças Crónicas in 2019 by Universidade de Coimbra Faculdade de Medicina, Mestrado in Mestrado em Investigação Biomédica in 2011 by Universidade de Coimbra Faculdade de Medicina and Licenciatura in Análises Clínicas e Saúde Pública in 2009/06 by Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra. Is Researcher in iNOVA4Health. Published 8 articles in journals. Has 1 patent(s) registered. Has received 4 awards and/or honors. Participates and/or participated as Researcher in 2 project(s). In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Health Sciences - Organs and Systems: Mechanisms of Disease; Multidisciplinary area; .
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Identification

Personal identification

Full name
Ana da Rosa Soares
Date of birth
1987/12/15
Gender
Female

Citation names

  • Soares, Ana
  • Soares, AR.
  • da Rosa Soares, A

Author identifiers

Ciência ID
851A-B138-DFB8
ORCID iD
0000-0002-0371-4610

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2014 - 2019/12/19
Concluded
 PhD Inter-University Doctoral Programme in Ageing and Chronic Diseases (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
"A new mechanism for selective protein loading into exosomes" (THESIS/DISSERTATION)
 Unanimously approved with Distinction and Honours
2009 - 2011
Concluded
 MSc Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"CD40 in oral squamous cell carcinoma - a possible role as a new therapeutic target" (THESIS/DISSERTATION)
 15
2005/09 - 2009/06
Concluded
 BSc Clinical Analysis and Public Health (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2024/03/01 - Current Contracted Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2023/10/01 - 2024/02/29 Contracted Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular, Portugal
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2020/10/01 - 2023/09/30 Postdoc (Research) Universidade de Lisboa Instituto de Medicina Molecular, Portugal
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2019/12 - 2020/10 Researcher (Research) iNOVA4Health, Portugal
2013/03/15 - 2014/09/28 Researcher (Research) CNC.IBILI, Portugal
2012 - 2013 Researcher (Research) CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
2007/09/03 - 2008/07/23 Estagio/ Laboratory traineeship Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2008/01/25 - 2008/04/25 Estagio/ Laboratory traineeship Debreceni Egyetem, Hungary
Projects

Grant

Designation Funders
2020/11/01 - Current Defining the role of Arp2/3 complex diversity at multiple scales of biology” (ERC-2018-SyG – ArpComplexity – GA 810207
810207
Post-doc
European Research Council
Ongoing
2019/01/01 - 2020/10 iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)
info:eu-repo/grantAgreement/FCT/5876/147260/PT
Researcher
Ongoing
2012/04/01 - 2014 An animal model for age-related changes in proteostasis
info:eu-repo/grantAgreement/FCT/COMPETE/118694/PT
Concluded

Contract

Designation Funders
2024/03/01 - Current Center for Optimized Oligo Escape and Control of Disease (COE)
N/A
Post-doc
Gulbenkian Institute for Molecular Medicine, Portugal
 Novo Nordisk A/S
Ongoing

Other

Designation Funders
2017 - 2020 Re-acidification of lysosomes as a novel therapy for age-related retinal degeneration
Boehringer
Researcher
Outputs

Publications

Conference abstract
  1. da Rosa Soares, A. "Role of ARP2/3 complex in biogenesis and maintenance of Transversal Tubules in Skeletal Muscle (Oral communication)". Paper presented in IMM PostDoc Day, 2022., 2022.
  2. Rosa Soares, A.. "A new mechanism for selective protein loading into exosomes. (Oral Presentation)". Paper presented in 1st CEDOC Symposium on Chronic Diseases, Lisbon, 2016.
  3. Rosa Soares, A.. "A new mechanism for selective protein loading into exosomes. (Oral Presentation)". Paper presented in EMBO Young Scientists Forum, Lisbon, 2016.
  4. Costa Moscoso, Francisco; Adragão, Pedro; Cavaco, Diogo; Carmo, Pedro; Galvão Santos, Pedro; Dores, Hélder; Carvalho, Maria Salomé; et al. "Atrial fibrillation ablation: predictors of recurrence, does paroxysmal af rule the outcome?". Paper presented in XXXIV Congresso Português de Cardiologia, Vilamoura, 2013.
    Published
  5. Rosa Soares, A.. "Are statins able to improve EPCs response of diabetic patients with myocardial infarction? (Oral Presentation)". Paper presented in TERM STEM, 2012.
  6. Rosa Soares, A.. "CD40 in oral squamous cell carcinoma - a possible role as a new therapeutic target. (Oral Presentation)". Paper presented in Actualizações em Oncologia 2012 – 26ªReunião, 1º congresso do CIMAGO., 2012.
Conference paper
  1. Girao, Henrique; Marques, Carla; Soares, Ana; Fernandes, Rosa; Pereira, Paulo. "Proteasome dysfunction in retinal pigment epithelium during aging contributes to the pathogenesis of Age-Macular related Degeneration". Paper presented in Acta Ophthalmologica, 2013.
    Published • 10.1109/icectech.2011.5941690
Conference poster
  1. da Rosa Soares, A. "Role of ARP2/3 complex in biogenesis and maintenance of Transversal Tubules in Skeletal Muscle.". Paper presented in IMM PostDoc Day, 2021, 2021.
  2. Rosa Soares, A.. "Selective Protein Sorting into Exosomes.". Paper presented in NOVA Science Day, Lisbon, 2019.
  3. Rosa Soares, A.. "Selective Protein Sorting into Exosomes.". Paper presented in Workshop Lysosome Biology, Lisbon, 2019.
  4. Rosa Soares, A.. "Selective Protein Sorting into Exosomes.". Paper presented in 1st Meeting on Vesicular Biology, Coimbra., 2018.
  5. Rosa Soares, A.. "Molecular mechanism of selective protein sorting into exosomes.". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction. Lisbon., 2017.
  6. Rosa Soares, A.. "Selective Protein Sorting into Exosomes.". Paper presented in FOOD FOR THOUGHTS - Nova Doctoral School, Lisbon., 2017.
  7. Rosa Soares, A.. "Understanding exosomes biogenesis: selective protein sorting.". Paper presented in 3rd PROTEOSTASIS Action Meeting - Proteostasis and its Biological Implications. Lisbon, 2016.
  8. Rosa Soares, A.. "The role of Cx43 in mediating intercellular communication goes beyond gap junctions.". Paper presented in HEART WITH]OUT[ BORDERS cardiovascular development, disease & repair, Porto., 2014.
  9. Rosa Soares, A.. "The role of Cx43 in mediating intercellular communication goes beyond gap junctions.". Paper presented in VI Annual Meeting of IBILI, Coimbra., 2014.
  10. Rosa Soares, A.. "Proteasomal dysfunction in aged retinal pigment epithelium contributes to Age-related Macular Degeneration progression.". Paper presented in 7th edition Meeting on Cell Signalling SINAL, Aveiro., 2013.
  11. Rosa Soares, A.. "Proteasomal dysfunction in aged retinal pigment epithelium contributes to Age-related Macular Degeneration progression.". Paper presented in V Annual Meeting of IBILI, Coimbra., 2013.
Journal article
  1. Avellaneda, Jerome; Candeias, Duarte; da Rosa Soares, Ana; Gomes, Edgar R.; Luis, Nuno Miguel; Schnorrer, Frank. "Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development". Current Biology (in press) (2024):
    10.1101/2024.09.16.613277
  2. João Vasco Ferreira; Ana da Rosa Soares; Paulo Pereira. "LAMP2A mediates the loading of proteins into endosomes and selects exosomal cargo". Autophagy 18 9 (2022): 2263-2265. http://dx.doi.org/10.1080/15548627.2022.2092315.
    10.1080/15548627.2022.2092315
  3. Joao Vasco Ferreira; Ana da Rosa Soares; Paulo Pereira. "Cell Non-autonomous Proteostasis Regulation in Aging and Disease". Frontiers in Neuroscience 16 (2022): http://dx.doi.org/10.3389/fnins.2022.878296.
    10.3389/fnins.2022.878296
  4. Ana da Rosa Soares; João Vasco Ferreira; José Ramalho; Catarina Máximo Carvalho; Maria Helena Cardoso; Petra Pintado; Ana Sofia Carvalho; et al. "LAMP2A regulates the loading of proteins into exosomes". Science Advances 8 12 (2022): https://doi.org/10.1126/sciadv.abm1140.
    10.1126/sciadv.abm1140
  5. Rosa Soares A; Ferreira JV; Ramalho JS; Ribeiro-Rodrigues T; Máximo C; Zuzarte M; Girão H; Pereira P. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis.". PloS one (2019): http://europepmc.org/abstract/med/31613922.
    10.1371/journal.pone.0223790
  6. Brandão AS; Bensimon-Brito A; Lourenço R; Borbinha J; Soares AR; Jacinto A. "Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration.". Journal of cell science (2019): http://europepmc.org/abstract/med/31636113.
    10.1242/jcs.231993
  7. Ana Rosa Soares; Tania Martins-Marques; Teresa Ribeiro-Rodrigues; Joao Vasco Ferreira; Steve Catarino; Maria João Pinho; Monica Zuzarte; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Sci. Rep. 5 (2015): 13243-13243. http://dx.doi.org/10.1038/srep13243.
    10.1038/srep13243
  8. Joao Vasco Ferreira; Ana Rosa Soares; Jose Silva Ramalho; Paulo Pereira; Henrique Girao. "K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy". Sci. Rep. 5 (2015): 10210-10210. http://dx.doi.org/10.1038/srep10210.
    10.1038/srep10210
  9. António N; Soares A; Fernandes R; Soares F; Lopes A; Carvalheiro T; Paiva A; et al. "Endothelial progenitor cells in diabetic patients with myocardial infarction - can statins improve their function?". (2014): http://europepmc.org/abstract/med/25066111.
    10.1016/j.ejphar.2014.07.010
  10. António N; Fernandes R; Soares A; Soares F; Lopes A; Carvalheiro T; Paiva A; et al. "Impact of prior chronic statin therapy and high-intensity statin therapy at discharge on circulating endothelial progenitor cell levels in patients with acute myocardial infarction: a prospective observational study.". (2014): http://europepmc.org/abstract/med/25048407.
    10.1007/s00228-014-1718-6
  11. António N; Soares A; Carvalheiro T; Fernandes R; Paiva A; Ventura M; Cristóvão J; et al. "Circulating endothelial progenitor cells as a predictor of response to cardiac resynchronization therapy: the missing piece of the puzzle?". (2014): http://europepmc.org/abstract/med/24383551.
    10.1111/pace.12334
  12. António N; Fernandes R; Soares A; Soares F; Lopes A; Carvalheiro T; Paiva A; et al. "Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum.". (2014): http://europepmc.org/abstract/med/24934236.
    10.1186/1475-2840-13-101
Preprint
  1. Ana Raquel Pereira; Ana da Rosa Soares; Tianyang Liu; Josie Liane Ferreira; Graciano Leal; Inês Faleiro; Naoko Kogata; et al. "Arp2/3 iso-complexes limit t-tubule overgrowth to ensure myofiber formation and synchronous contraction". 2024. https://doi.org/10.1101/2024.08.13.607563.
    10.1101/2024.08.13.607563

Intellectual property

Patent
  1. Rosa Soares, A.. 2020. "A method for selective loading of proteins into exosomes and products thereof".

Other

Other output
  1. LAMP2A regulates the loading of proteins into exosomes. 2021. João Vasco Ferreira; Ana da Rosa Soares; José Ramalho; Catarina Máximo Carvalho; Maria Helena Cardoso; Petra Pintado; Ana Sofia Carvalho; et al. https://doi.org/10.1101/2021.07.26.453637.
    10.1101/2021.07.26.453637
  2. Standard Operating Procedure and Risk Assessment Document COVID-19 task force. The document describes the standard operating procedure (SOP) and the risk assessment protocol prepared for the NOVA Medical School task force (NMS/CEDOC) with the purpose of assisting the Portuguese community on the diagnosis for Coronavirus disease 2019 (COVID-19). Ana Oliveira; Ana Soares; Catarina Pinto; Claudia Nunes dos Santos; Teresa Gomes; Regina Menezes.. 2020. Soares, Ana. http://cedoc.unl.pt/wp-content/uploads/2020/04/COVID-19-Task-Force_CEDOC_v1_19_04_2020.pdf..
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 Role of ARP2/3 complex in biogenesis and maintenance of Transversal Tubules in Skeletal Muscle IMM PostDoc Day, 2022
2017 Envelhecimento e a doença de Alzheimer. V Congresso da Saúde da Escola Secundária da Amora
Escola Secundária da Amora, Seixal (Portugal)
2016 A new mechanism for selective protein loading into exosomes. 1st CEDOC Symposium on Chronic Diseases
2016 A new mechanism for selective protein loading into exosomes. EMBO Young Scientists Forum
2012 CD40 in oral squamous cell carcinoma - a possible role as a new therapeutic target. XII Jornadas Análises Clínicas e Saúde Pública
Escola Superior de Tecnologias da Saúde de Coimbra
2012 Are statins able to improve EPCs response of diabetic patients with myocardial infarction? TERM STEM
2012 CD40 in oral squamous cell carcinoma - a possible role as a new therapeutic target. 1º congresso do CIMAGO. Actualizações em Oncologia

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - 2024/07/12 Role of mitochondria dynamics in skeletal muscle differentiation.
Supervisor
 Biomedical Research (Master)
Universidade de Lisboa Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/10/28 - 2024/10/30 Attended the Meeting of the Center for Optimized Oligo Escape and Control of Disease (COE) in Copenhagen. The event provided an opportunity to engage with the teams involved in the project, present research findings, and participate in discussions to exchange ideas and insights, fostering collaboration and alignment on project goals.
Symposium
 Delivery of oligonucleotide pharmaceutics
Københavns Universitet - Nørre Campus, Denmark

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Uncovering the mechanism of CD2AP behind Alzheimer's disease
(Thesis) Main arguer
 Tiago Miguel Piconêz (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 Purification and characterization of dysfunctional lysosomes in an age-related macular disease model
(Thesis) Main arguer
 Miguel Ângelo Martins Mesquita (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Association member

Society Organization name Role
2014/05 - 2015/04 GEIVEX - Grupo Espanol innovacion e investigacion en vesiculas extracelulares

Committee member

Activity description
Role 		Institution / Organization
2017 - 2017 PhD Student Committee for the organization of PhD Program Meeting. https://viphdocmeeting.weebly.com/programme.html
Member
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Mentoring / Tutoring

Topic Student name
2024/09 - Current Tutor of a PhD Student Gabriele Salvatore Motta
Distinctions

Other distinction

2016 Best Oral Communication Award-1st CEDOC Symposium on Chronic Diseases, Lisbon.
2015 PhD Fellowship PD/BD/106052/2015
Fundação para a Ciência e a Tecnologia, Portugal
2014 Best Poster Award - VI Annual Meeting of IBILI
2012 Travel Award for Oral Communication