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Francisca Dias is currently a Júnior Researcher in the Molecular Oncology and Viral Pathology Group from the IPO-Porto Research Center (CI-IPOP) in Porto. She obtained her BSc in Biochemistry (2012), MSc in Oncology (2014) and PhD in Biomedical Sciences (2020), all from the University of Porto. Her PhD project was carried out at IPO-Porto Research Center in collaboration with the Department of Genetics from the University Medical Center of Groningen (UMGC) in the Netherlands. The PhD research was focused on the study of the miRNA and mRNA content from extracellular vesicles (EVs) obtained from the plasma of clear cell Renal Cell Carcinoma (ccRCC) patients with the aim of defining new prognostic biomarkers able of predicting a more aggressive disease. She has authored or co-authored 46 international scientific publications and 4 book chapters (h-index: 14). Until now, she has supervised 4 undergraduate students and co-supervised 10 MSc students and is currently supervising 2 MSc students and co-supervising a PhD student. Her current research is focused on the study and characterization of cancer EV cargo , more specifically their miRNA content, and how that can be used to design new therapeutic approaches and patients' stratification algorithms. Moreover she is also involved in the study of EV-miRNAs and other circulating biomarkers to define new biomarkers of COVID-19 vaccination immune response in cancer patients under active treatment.
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Identification

Personal identification

Full name
Francisca Guilherme Carvalho Dias

Citation names

  • Dias, Francisca

Author identifiers

Ciência ID
851B-027C-DCB3
ORCID iD
0000-0002-4993-4467
Researcher Id
P-1272-2018
Scopus Author Id
7102398985

Email addresses

  • Francisca.Carvalho.Dias@ipoporto.min-saude.pt (Professional)
  • francisca.dias92@gmail.com (Personal)

Telephones

Telephone
  • 225084000 Ext.: 5115 (Professional)

Addresses

  • Rua Dr Bernardino de Almeida, 4200-072, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Clinical Medicine - Urology and Nephrology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/05/03 - 2021/05/07
Concluded
 Molecular Bioinformatics - Pratical Course (Outros)
Universidade do Porto Faculdade de Medicina, Portugal
 18 valores
2015 - 2020/07/16
Concluded
 Biomedical Sciences (Doctor of Philosophy)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Synergic effect of microRNAs and metalloproteinases derived from extracellular vesicles in the establishment of the metastatic niche in renal cell carcinoma " (THESIS/DISSERTATION)
2018/09/17 - 2019/01/24
Concluded
 Curso Avançado em Análises Clínicas (Outros)
Major in Análises Clínicas Laboratoriais
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 17 valores
2016/05/09 - 2016/05/20
Concluded
 1st Advanced Course in Clinical and Molecular Virology (Outros)
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 15 valores
2012 - 2014/12/10
Concluded
 Oncology (Master)
Major in Molecular Oncology
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Circulating MicroRNAs and Renal Cell Carcinoma" (THESIS/DISSERTATION)
 18/20
2009 - 2012/09/08
Concluded
 Biochemistry (Bachelor)
Universidade do Porto Faculdade de Ciências, Portugal
"Influência de Polimorfismos Genéticos Funcionais no desenvolvimento de Carcinoma de Células Renais: o exemplo do EGFR -191C>A" (THESIS/DISSERTATION)
 14/20
Affiliation

Science

Category
Host institution 		Employer
2021/04/01 - 2025/03/21 Contracted Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2017/02/09 - 2021/03/31 Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2015/02 - 2017/01 Researcher (Research) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2012/02 - 2015/02 Research Trainee (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2025/03 - Current Assistant Professor (University Teacher) Universidade Fernando Pessoa, Portugal
Universidade Fernando Pessoa - Escola de Medicina e Ciências Biomédicas, Portugal
Projects

Contract

Designation Funders
2022 - Current Evaluation of the Immunologic Response to COVID-19 Vaccination in Oncological Patients – OnCOVac
OnCOVac.PT
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
AstraZeneca Produtos Farmacêuticos Lda
Ongoing
2017/02/07 - Current Early-Stage cancer treatment, driven by context of molecular imaging (ESTIMA)
NORTE-01-0145-FEDER-00027
PhD Student Fellow
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Ongoing
2017 - Current Definitive chemoradiotherapy response prediction in esophageal carcinoma
CI-IPOP-79-2017
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Ongoing
2015 - Current MicroRNAs and microbioma in gastric carcinogenesis and their association with different innate immunity expression profiles
CI-IPOP-28-2015
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Ongoing
2015 - Current Renal Cell Carcinoma-derived exosomes: the miRNA content as new disease predictive biomarkers and an opportunity to invasive/metastatic disease
CI-IPOP-21-2015
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Ongoing
2018/08 - 2022/01 NanoWar2UrCancer- Sensitization of urologic tumors therapy driven by nanotechnology
PTDC/MED-QUI/29800/2017
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/07/01 - 2021/03/31 Novel siRNA therapies against metastatic colorectal cancer (SIRNAC)
NORTE-01-0247-FEDER-033399
Research Fellow
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Concluded
2019/01/01 - 2019/12/31 Centro de Investigação do Instituto Português de Oncologia do Porto
UID/DTP/00776/2019
UID/DTP/04750/2019
UIDB/04750/2020
UIDB/00776/2020
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universidade do Porto Instituto de Saúde Pública, Portugal

Universidade do Porto Unidade de Investigação em Epidemiologia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Gomes Morais, Mariana; Guilherme Carvalho Dias, Francisca; Alexandre Velho Prior, João; Luísa Pereira Teixeira, Ana; Manuel de Medeiros Melo Silva, Rui. "The Impact of Oxidoreductases-Related MicroRNAs in Glucose Metabolism of Renal Cell Carcinoma and Prostate Cancer". In Oxidoreductase. IntechOpen, 2021.
    Published • 10.5772/intechopen.93932
  2. Dias, Francisca; Teixeira, Ana Luísa; Medeiros, Rui. "Farmacogenética no Carcinoma da Próstata Resistente à Castração". In Farmacologia Clínica – Carcinoma da Próstata Resistente à Castração, edited by Farmacologia Clínica – Carcinoma da Próstata Resistente à Castração, 11-184. Lisboa, Portugal: Grupo Português Génito-Urinário, 2018.
    Published
  3. Medeiros, Rui; Teixeira, Ana Luísa; Dias, Francisca; Begonha, Rosa. "Farmacogenética no Carcinoma de Células Renais Metastizado". In Farmacologia Clínica - Carcinoma de Células Renais Metastizado, edited by F. Calais da Silva. Lisboa, Portugal: Grupo Português Génito-Urinário, 2017.
    Published
  4. Teixeira, Ana Luísa; Dias, Francisca; Medeiros, Rui. "Oncobiologia". In Tumores Malignos- Tracto génito-urinário, edited by F. Calais da Silva, 24-32. Lisboa, Portugal: Grupo Português Génito-Urinário, 2016.
    Published
Conference poster
  1. Tânia R. Dias; Beatriz Almeida; Pedro Cruz; Mário Sousa Pimenta; Sousa, Hugo; Teixeira, Ana Luísa; Julio Oliveira; Dias, Francisca; Rui Manuel de Medeiros Melo Silva. Corresponding author: Rui Manuel de Medeiros Melo Silva. "MicroRNAs as potential biomarkers for immune response profile to COVID-19 vaccine boost in cancer patients". Paper presented in One Health PhD Forum, 2024.
  2. Tânia R. Dias; Beatriz Almeida; Pedro Cruz; Mário Sousa Pimenta; Sousa, Hugo; Teixeira, Ana Luísa; Júlio Oliveira; Dias, Francisca; Rui Manuel de Medeiros Melo Silva. Corresponding author: Rui Manuel de Medeiros Melo Silva. "Perfil de microRNAs na resposta à vacinação da COVID-19 em doentes com cancro e em tratamento ativo". Paper presented in IPO Porto Summit, 2024.
  3. Teixeira, Ana Luísa; Dias, Francisca; Patrão, Ana Sofia; Morais, Mariana; Ferreira, Marta; Silva, Alexandra; Vilhena, Manuela; Morais, António. Corresponding author: Teixeira, Ana Luísa. "miRNAs-derivados de vesículas extracelulares envolvidos na regulação de AGO2 como potenciais biomarcadores de prognóstico no carcinoma de células renais de células claras". Paper presented in IPO PORTO SUMMIT, 2024.
  4. Beatriz Almeida; Dias, Francisca; Tânia R. Dias; Pedro Cruz; Mário Sousa Pimenta; Sousa, Hugo; Júlio Oliveira; Rui Manuel de Medeiros Melo Silva. "Extracellular vesicles derived microRNAs: Biomarkers for immune response profile to COVID-19 boost vaccination in cancer patients under active treatment". Paper presented in 30th Porto Cancer Meeting, 2024.
  5. Venâncio, Patrícia; Dias, Francisca; Teixeira, Ana Luísa; MEDEIROS, RUI. "MicroRNAs-derivados de vesículas extracelulares na modulação do carcinoma de células renais". Paper presented in IPO PORTO SUMMIT, 2024.
  6. Almeida, Beatriz; Tânia R. Dias; Pedro Cruz; Mário Sousa Pimenta; Hugo Sousa; Júlio Oliveira; Dias, Francisca; Rui Manuel de Medeiros Melo Silva. "Extracellular vesicles derived microRNAs: Biomarkers for immune response profile to COVID-19 boost vaccination under active treatment in cancer patients". Paper presented in 1st Young Research Day, 2023.
  7. Tânia R. Dias; Dias, Francisca; Pedro Cruz; Mário Pimenta; Sousa, Hugo; Teixeira, Ana Luísa; Júlio Oliveira; Rui Medeiros. Corresponding author: Rui Medeiros. "MicroRNAs immune response profile to COVID-19 vaccine boost in cancer patients under active treatment". Paper presented in 1st Young Researchers' Day, 2023.
  8. Tavares, Inês; Morais, Mariana; Dias, Francisca; Bidarra, Silvia; MEDEIROS, RUI; Teixeira, Ana Luísa. "Extracellular vesicles-derived microRNAs: mediators of enzalutamide resistance in Prostate Cancer". Paper presented in 1st Young Researchers Symposium - Portuguese Oncology Institute of Oncology of Porto Research Center, 2023.
  9. Venancio, Patricia; Dias, Francisca; MEDEIROS, RUI; Teixeira, Ana Luísa. "Extracellular Vesicles derived-microRNAs and renal cell carcinoma phenotype modulation". Paper presented in 1st Young Researchers Symposium - Portuguese Oncology Institute of Oncology of Porto Research Center, 2023.
  10. Pedro Cruz; Tânia R. Dias; Dias, Francisca; Mario Pimenta; Sousa, Hugo; Rui Medeiros; Júlio Oliveira. "Lower Response to COVID-19 Booster Dose Vaccination on Cancer Patients Comparing to Healthy Controls". Paper presented in ESMO: European Society of Medical Oncology Congress, 2023.
  11. Pedro Cruz; Dias, Francisca; Tânia R. Dias; Mário Pimenta; Sousa, Hugo; Rui Medeiros. "Cancer patients under immunotherapy: Lower response to COVID19 Booster Dose Vaccination compared to healthy controls". Paper presented in Cancer Core Europe, Summer School in Translational Cancer Research, 2023.
  12. Beatriz Ferreira Almeida; Tânia R. Dias; Pedro Cruz; Mário Sousa-Pimenta; Sousa, Hugo; Júlio Oliveira; Dias, Francisca; Rui Medeiros. Corresponding author: Rui Medeiros. "MicroRNAs derivados de Vesículas Extracelulares: Biomarcadores de resposta imunológica dos doentes oncológicos sob tratamento ativo à vacinação de reforço anti-COVID-19". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  13. Vânia Dias; Tânia R. Dias; Pedro Cruz; Mário Sousa-Pimenta; Sousa, Hugo; Júlio Oliveira; Dias, Francisca; Rui Medeiros. "Avaliação do impacto de polimorfismos genéticos nos genes ACE2 e TMPRSS2 na suscetibilidade à infeção por SARS-CoV-2 em doentes com cancro". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  14. Dias, Francisca; Teixeira, Ana Luísa; Mirjam Mastik; Isabel Vieira; José Silva; Maria Joaquina Maurício; António Joaquim de Pinho Morais; et al. "Plasma EV-derived hsa-miR-4521 as a potential biomarker of clear cell Renal Cell Carcinoma aggressiveness”". Paper presented in EACR 2023 Conference, 2023.
  15. Teixeira, Ana Luísa; Dias, Francisca; Patrão, Ana; Morais, Mariana; Ferreira, Marta; Silva, Alexandra; Morais, António; et al. "Extracellular vesicles-AGO2-related microRNAs as potential prognosis biomarkers in clear-cell renal cell carcinoma". Paper presented in EACR 2023 Conference, 2023.
  16. Morais, Mariana; Figueiredo, Patrícia; Dias, Francisca; Tavares, Inês; Mikkonen, KS; Teixeira, Ana Luísa; MEDEIROS, RUI. "Caveolae-dependent endocytosis is responsible for the selective effect of Silver Nanoparticles in Prostate Cancer Sensitive and Resistant to Androgen Deprivation Therapy". Paper presented in EACR 2023 Conference, 2023.
  17. Almeida, Cristina; Teixeira, Ana Luísa; Machado, Vera; Dias, Francisca; MEDEIROS, RUI. "MicroRNA-122-5p inhibits cell proliferation of colorectal cancer cells through downregulation of LAT1 and ASCT2". Paper presented in 4th National Meeting of Young Investigators in Oncology, 2022.
  18. Almeida, Cristina; Dias, Francisca; Machado, Vera; Teixeira, Ana Luísa; Medeiros, Rui. "MicroRNA-122-5p inibe a proliferação celular de células de cancro colorretal, através da downregulation de LAT1 e ASCT2". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia, 2022.
  19. Vânia Dias; Dias, Francisca; Tânia R. Dias; Beatriz Almeida; Pedro Cruz; Mário Sousa Pimenta; Júlio Oliveira; Rui Manuel de Medeiros Melo Silva. "Evaluation of the impact of genetic polymorphisms in ACE2 and TMPRSS2 on the susceptibility to SARS-CoV-2 infection in cancer patients". Paper presented in VIII Jornadas da Bioquímica, 2022.
  20. Almeida, Cristina; Dias, Francisca; Machado, Vera; Carlos Palmeira; Gabriela Martins; Costa-Silva, Bruno; Ana Luísa Teixeira; MEDEIROS, RUI. "LAT1 mRNA as a potential therapeutic target in colorectal cancer". Paper presented in 3rd National Meeting of Young Investigators in Oncology, 2021.
  21. Almeida, Cristina; Dias, Francisca; Machado, Vera; Palmeira, Carlos; Martins, Gabriela; Costa-Silva, Bruno; Teixeira, Ana Luísa; MEDEIROS, RUI. "LAT1 mRNA como potencial alvo terapêutico no cancro colorretal". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  22. Morais, Mariana; Machado, Vera; Figueiredo, Patrícia; Dias, Francisca; Mikkonen, KS; Teixeira, Ana Luísa; MEDEIROS, RUI. "Nanopartículas de prata funcionalizadas com glucose como potenciais agentes terapêuticos em Cancro de Próstata resistente à Terapia de Bloqueio Androgénico". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  23. Tavares, Inês ; Morais, Mariana; Dias, Francisca; Teixeira, Ana Luísa; MEDEIROS, RUI. "O efeito de Warburg no processo de aquisição de resistência à Terapia de Bloqueio Androgénico". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  24. Almeida, Cristina; Dias, Francisca; Teixeira, Ana Luísa; Machado, Vera; Palmeira, Carlos; Martins, Gabriela; MEDEIROS, RUI. "LAT1 mRNA derived from extracellular vesicles of colorectal cancer alter the phenotype of recipient cells". Paper presented in 1st Meeting of the Portuguese Network on Extracellular vesicles, 2021.
  25. Morais, Mariana; Machado, Vera; Dias, Francisca; Palmeira, Carlos; Martins, Gabriela; Fonseca, Magda; Martins, Catarina; et al. "The cytotoxic potential of starch-capped silver-nanoparticles (AgNPs) and their ability to induce cell cycle arrest in prostate cancer cells". Paper presented in XVII Congress of the Iberian Society of Cytometry ¿ SIC 2021, 2021.
  26. Dias, Francisca. "Influência de mRNA LAT1 derivado de vesículas extracelulares na progressão de cancro coloretal". Paper presented in 2º Encontro de Jovens Investigadores, 2020.
  27. Almeida, Cristina; Teixeira, Ana Luísa; Dias, Francisca; Nogueira, Inês; Machado, Vera; Barbosa, Inês; Palmeira, Carlos; Martins, Gabriela; MEDEIROS, RUI. "Influência de mRNA LAT1 derivado de vesículas extracelulares na progressão do cancro colorretal". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia., 2020.
  28. Dias, Francisca. "O potencial citotóxico de nanopartículas de prata com capping the amido no Cancro da Próstata Resistente à Castração". Paper presented in 16º Congresso Nacional de Oncologia, 2019.
  29. Dias, Francisca. "mRNA TIMP1 derivado de vesículas extracelulares como biomarcador de agressividade no CCRcc". Paper presented in 16º Congresso Nacional de Oncologia, 2019.
  30. Morais, Mariana; Machado, Vera; Dias, Francisca; Fonseca, Magda; Teixeira, Ana Luísa; Prior, João A.V.; Medeiros, Rui. "O potencial citotóxico de nanopartículas de prata com capping de amido no Cancro da Próstata Resistente à Castração". Paper presented in Congresso Nacional de Oncologia 2019, 2019.
  31. Teixeira, Ana Luísa; Dias, Francisca; Silva, Carlos; Morais, Mariana; Nogueira, Inês; Patrão, Sofia; Maurício, Joaquina; Medeiros, Rui. "SNPs no gene AGO2: influência nos níveis circulantes de mRNA e na progressão do carcinoma de células renais". Paper presented in 15º Congresso Nacional de Oncologia, 2019.
  32. Dias, Francisca. "Influence of the starch dissolution approach in the green synthesis of starch-capped silver nanoparticles". Paper presented in Encontro Galego-Português de Química, 2019.
  33. Dias, Francisca. "Leukocyte telomere length and hTERT genetic polymorphism rs2735940 influence renal cell carcinoma outcome". Paper presented in 11th Symposium on Metabolism, 2019.
  34. Morais, Mariana; Dias, Francisca; Resende, Telma; Nogueira, Inês; Oliveira, Jorge; Maurício, Joaquina; Teixeira, Ana Luísa; Medeiros, Rui. "Leukocyte telomere length and hTERT genetic polymorphism rs2735940 influence renal cell carcinoma clinical outcome". Paper presented in 11th Simposium on Metabolism, 2019.
  35. Dias, Francisca. "Resistência ao Everolimus em carcinoma de células renais de células claras: influência do miRNA-101 e do HIF-2a". Paper presented in 1º Encontro de Jovens Investigadores, 2019.
  36. Dias, Francisca. "GLUT-1 Related miR-144 and miR-186: linking cancer cell metabolism disruption to clear cell Renal Cell Carcinoma". Paper presented in 1º Encontro de Jovens Investigadores, 2019.
  37. Adem, B; Teixeira, AL; Dias, F; Medeiros, R; Ruivo, C; Melo, S. "GE11 positive exosomes as a potential RNAi delivery in clear cell Renal Cell Carcinoma". Paper presented in 12th YES Meeting, 2017.
  38. Dias F; Teixeira, AL; Adem, B; Bastos N; Vieira J; Maurício J; Oliveira J; Kok K; Medeiros R. "Microenvironment modulation in renal cell carcinoma by extracellular miR-210 and miR-1233: implications in disease aggressiveness". Paper presented in 2nd ASPIC International Congress, 2016.
  39. Teixeira, A.L.; Dias, F.; Ferreira, M.; Santos, J.I; Gomes, M.; Lobo, F.; Maurício, J.; Machado, J.C.; Medeiros, R.. "Influence of EGF+61G>A and TGFB+869T>C polymorphisms in renal cell carcinoma development: the link to circulating microRNAs". Paper presented in 1st ASPIC Internacional Congress, 2015.
  40. Dias, Francisca; Teixeira, Ana Luísa; Ribeiro, Bárbara; Bastos, Nuno; Fernandes, Mara; Sequeiros, Maria Inês; Maurício, Joaquina; et al. "Hypoxia modulation in Renal Cell Carcinoma by extracellular levels of miR-210 and miR-1233: Implications in time-to-disease progression". Paper presented in 8th ECCO - 40th ESMO European Cancer Congress, 2015.
  41. Teixeira, A.L.; Dias, F.; Ferreira, M.; Santos, J.I.; Gomes, M.; Lobo, F.; Maurício, J.; Machado, J.C.; Medeiros, R.. "Synergistic influence of EGF+61G>A and TGFB+869T>C polymorphisms in renal cell carcinoma progression and overall survival: the link to plasma circulating microRNAs". Paper presented in 7th Santorini Conference: Systems Medicine, Personalized Health and Therapy, 2014.
  42. Santos, J.I.; Teixeira, A.L.; Dias, F.; Gomes, M.; Nogueira, A.; Assis, J.; Lobo, F.; et al. "Influence of GEMIN4 rs7813 (T>C) functional polymorphism in time to castration-resistance in prostate cancer patients submitted to androgen deprivation therapy". Paper presented in ESPT 2013 Second Conference, 2013.
  43. Teixeira, A.L.; Gomes, M.; Nogueira, A.; Dias, F.; Santos, J.I.; Lobo, F.; Morais, A.; Maurício, J.; Medeiros, R.. "Influence of TGFBR2-875G>A polymorphism in gene expression and castration-resistant prostate cancer development". Paper presented in ESPT 2013 Second Conference, 2013.
  44. Dias, F.; Teixeira, A.L.; Ferreira, M.; Santos, J.I.; Gomes, M.; Nogueira, A.; Assis, J.; Maurício, J.; Medeiros, R.. "Overall survival in renal cell carcinoma patients: the influence of GEMIN4 rs7813 (T>C) functional polymorphism". Paper presented in ESPT 2013 Seconde Conference., 2013.
Journal article
  1. Alves, Ângela; Ferreira, Mariana; Eiras, Mariana; Lima, Luís; Medeiros, Rui; Teixeira, Ana Luísa; Dias, Francisca. "Exosome-derived hsa-miR-200c-3p, hsa-miR-25-3p and hsa-miR-301a-3p as potential biomarkers and therapeutic targets for restoration of PTEN expression in clear cell renal cell carcinoma". International Journal of Biological Macromolecules 302 (2025): 140607. https://doi.org/10.1016/j.ijbiomac.2025.140607.
    In press • 10.1016/j.ijbiomac.2025.140607
  2. Lucas Rafael Lopes; Daniel Escorsim Machado; Rodrigo Araújo Goes; Marcus Vinícius Galvão Amaral; Francisca Dias; Valéria Tavares; Rui Medeiros; Jamila Alessandra Perini. "Implications of tendinopathy on the sports career: Epidemiological and clinical profile of high-performance athletes". Physical Therapy in Sport (2025): https://doi.org/10.1016/j.ptsp.2025.02.003.
    10.1016/j.ptsp.2025.02.003
  3. Lucas Rafael Lopes; Rui Medeiros; Valéria Tavares; Francisca Dias; Marcus Vinícius Galvão Amaral; Rodrigo Araújo Goes; João Antonio Matheus Guimarães; Jamila Alessandra Perini. "A Systematic Review and Meta-Analysis on Aerobic Fitness Dynamics in Post-COVID-19 Athletes: Implications in the Return-to-Play Performance". Sports (2025): https://doi.org/10.3390/sports13020040.
    10.3390/sports13020040
  4. Tiago Ferreira; Francisca Dias; Ângela Alves; Adelina Gama; João F. Mano; Paula A. Oliveira; Rui Medeiros. "Let-7b, miR-29b, and miR-125b as Potential Biomarkers for Differentiating Canine Mammary Carcinoma Histological Types". Animals (2024): https://doi.org/10.3390/ani15010020.
    10.3390/ani15010020
  5. Lucas Rafael Lopes; Marcus Vinícius Galvão Amaral; Rodrigo Araujo Goes; Valéria Tavares; Francisca Dias; Rui Medeiros; Daniel Escorsim Machado; Jamila Alessandra Perini. "Tenascin-C-Matrix Metalloproteinase-3 Phenotype and the Risk of Tendinopathy in High-Performance Athletes: A Case–Control Study". Diagnostics (2024): https://doi.org/10.3390/diagnostics14222469.
    10.3390/diagnostics14222469
  6. Júlio Oliveira; Pedro Cruz; Tânia R. Dias; Mário Sousa-Pimenta; Beatriz Almeida; Bruno Soares; Hugo Sousa; et al. "Humoral Response to SARS-CoV-2 Vaccine-Boost in Cancer Patients: A Case Series from a Southern European Cancer Center". Vaccines (2024): https://doi.org/10.3390/vaccines12111207.
    10.3390/vaccines12111207
  7. Mariana Morais; Francisca Dias; Patrícia Figueiredo; Inês Tavares; Carla Escudeiro; Manuel Teixeira; Alexandra Teixeira; et al. "Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer". International Journal of Nanomedicine (2024): https://doi.org/10.2147/IJN.S447645.
    10.2147/IJN.S447645
  8. Alves, Ângela; Medeiros, Rui; Teixeira, Ana Luísa; Dias, Francisca. "Decoding PTEN regulation in clear cell renal cell carcinoma: Pathway for biomarker discovery and therapeutic insights". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1879 5 (2024): 189165. https://doi.org/10.1016/j.bbcan.2024.189165.
    10.1016/j.bbcan.2024.189165
  9. Beatriz Almeida; Tânia R. Dias; Pedro Cruz; Mário Sousa-Pimenta; Ana Luísa Teixeira; Catarina Esteves Pereira; Bruno Costa-Silva; et al. "Plasma EV-miRNAs as Potential Biomarkers of COVID-19 Vaccine Immune Response in Cancer Patients". Vaccines (2024): https://doi.org/10.3390/vaccines12080848.
    10.3390/vaccines12080848
  10. Ferreira, Tiago; da Costa, Rui M. Gil; Dias, Francisca; Gama, Adelina; Gaspar, Vítor M.; Mano, João F.; Oliveira, Paula A.; Medeiros, Rui. "Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors". GeroScience 46 6 (2024): 6641-6657. https://doi.org/10.1007/s11357-024-01260-7.
    10.1007/s11357-024-01260-7
  11. Silva, Fernando; Veiga, Francisco; Cardoso, Catarina; Dias, Francisca; Cerqueira, Fátima; Medeiros, Rui; Cláudia Paiva-Santos, Ana. "A rapid and simplified DPPH assay for analysis of antioxidant interactions in binary combinations". Microchemical Journal 202 (2024): 110801. http://dx.doi.org/10.1016/j.microc.2024.110801.
    10.1016/j.microc.2024.110801
  12. Tavares, Inês; Morais, Mariana; Dias, Francisca; Medeiros, Rui; Teixeira, Ana Luísa. "Deregulated miRNAs in enzalutamide resistant prostate cancer: A comprehensive review of key molecular alterations and clinical outcomes". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1879 2 (2024): 189067. http://dx.doi.org/10.1016/j.bbcan.2023.189067.
    10.1016/j.bbcan.2023.189067
  13. Morais, Mariana; Dias, Francisca; Figueiredo, Patrícia; Tavares, Inês; Escudeiro, Carla; Teixeira, Manuel R.; Teixeira, Alexandra; et al. "Glucose-functionalized Silver Nanoparticles (G-AgNPs) uptake by caveolae-dependent endocytosis is responsible for their selective effect towards Castration Resistant Prostate Cancer". International Journal of Nanomedicine (2024):
    Under revision
  14. Tavares, Inês; Morais, Mariana; Dias, Francisca; Ferreira, Mariana; Martins, Gabriela; Fernandes, Rui; Bidarra, Silvia; Teixeira, Ana Luísa. Corresponding author: Teixeira, Ana Luísa. "Extracellular vesicles derived-microRNAs predicting enzalutamide resistance in 3D spheroid prostate cancer model". International Journal of Biological Macromolecules (2024):
    In press
  15. Mariana Morais; Vera Machado; Patrícia Figueiredo; Francisca Dias; Rogéria Craveiro; Joana Lencart; Carlos Palmeira; et al. "Silver Nanoparticles (AgNPs) as Enhancers of Everolimus and Radiotherapy Sensitivity on Clear Cell Renal Cell Carcinoma". Antioxidants (2023): https://doi.org/10.3390/antiox12122051.
    10.3390/antiox12122051
  16. Beatriz Almeida; Tânia R. Dias; Ana Luísa Teixeira; Francisca Dias; Rui Medeiros. "MicroRNAs Derived from Extracellular Vesicles: Keys to Understanding SARS-CoV-2 Vaccination Response in Cancer Patients?". Cancers (2023): https://doi.org/10.3390/cancers15164017.
    10.3390/cancers15164017
  17. Cristina Almeida; Ana Luísa Teixeira; Francisca Dias; Mariana Morais; Rui Medeiros. "Extracellular Vesicles as Potential Therapeutic Messengers in Cancer Management". Biology (2023): https://doi.org/10.3390/biology12050665.
    10.3390/biology12050665
  18. Bruno Horta; Joana Freitas-Silva; Jani Silva; Francisca Dias; Ana Luísa Teixeira; Rui Medeiros; Honorina Cidade; Madalena Pinto; Fátima Cerqueira. "Antitumor Effect of Chalcone Derivatives against Human Prostate (LNCaP and PC-3), Cervix HPV-Positive (HeLa) and Lymphocyte (Jurkat) Cell Lines and Their Effect on Macrophage Functions". Molecules (2023): https://doi.org/10.3390/molecules28052159.
    10.3390/molecules28052159
  19. Varandas, Tatiana; Dias, Francisca; Sousa, Ana; Sousa, Maria; Medeiros, Rui. "Characterization of genetic polymorphisms CYP2R1 rs2060793 and CYP2R1 rs12794714: potential biomarkers in endometriosis predisposition [artigo]". (2023): http://hdl.handle.net/10400.22/23663.
    10.26537/prpaeh.v1i1.5287
  20. Mariana Morais; Vera Machado; Francisca Dias; Patrícia Figueiredo; Carlos Palmeira; Gabriela Martins; Rui Fernandes; et al. "Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells". International Journal of Nanomedicine (2022): https://doi.org/10.2147/IJN.S364862.
    10.2147/IJN.S364862
  21. Tânia R. Dias; Francisca Dias; Ana Luísa Teixeira; Hugo Sousa; Júlio Oliveira; Rui Medeiros. "MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination Response". Cells 11 15 (2022): 2279-2279. https://doi.org/10.3390/cells11152279.
    10.3390/cells11152279
  22. Cristina Almeida; Ana Luísa Teixeira; Francisca Dias; Vera Machado; Mariana Morais; Gabriela Martins; Carlos Palmeira; et al. "Extracellular Vesicles Derived-LAT1 mRNA as a Powerful Inducer of Colorectal Cancer Aggressive Phenotype". Biology (2022): https://doi.org/10.3390/biology11010145.
    10.3390/biology11010145
  23. Ana Luísa Teixeira; Ana Sofia Patrão; Francisca Dias; Carlos Silva; Isabel Vieira; José Fernando Silva; Marta Ferreira; et al. "AGO2 expression levels and related genetic polymorphisms: influence in renal cell progression and aggressive phenotypes". Pharmacogenomics 22 16 (2021): 1069-1079. https://doi.org/10.2217/pgs-2021-0072.
    10.2217/pgs-2021-0072
  24. Rui Medeiros; Bruno Horta; Joana Freitas-Silva; Jani Silva; Francisca Dias; Emília Sousa; Madalena Pinto; Fátima Cerqueira. "Effect of 1-Carbaldehyde-3,4-dimethoxyxanthone on Prostate and HPV-18 Positive Cervical Cancer Cell Lines and on Human THP-1 Macrophages". Molecules (2021): https://doi.org/10.3390/molecules26123721.
    10.3390/molecules26123721
  25. Mariana Morais; Francisca Dias; Inês Nogueira; Anabela Leão; Nuno Gonçalves; Luís Araújo; Sara Granja; et al. "Cancer Cells’ Metabolism Dynamics in Renal Cell Carcinoma Patients’ Outcome: Influence of GLUT-1-Related hsa-miR-144 and hsa-miR-186". Cancers 13 7 (2021): 1733-1733. https://doi.org/10.3390/cancers13071733.
    10.3390/cancers13071733
  26. Francisca Dias; Cristina Almeida; Ana Luísa Teixeira; Mariana Morais; Rui Medeiros. "LAT1 and ASCT2 Related microRNAs as Potential New Therapeutic Agents against Colorectal Cancer Progression". Biomedicines (2021): https://doi.org/10.3390/biomedicines9020195.
    10.3390/biomedicines9020195
  27. Cardoso, Jéssica Vilarinho; Medeiros, Rui; Dias, Francisca; Costa, Isabelle Alves; Ferrari, Renato; Berardo, Plinio Tostes; Perini, Jamila Alessandra. "DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: Case-control and review studies.". Experimental and Molecular Pathology 119 (2021): 104616. https://www.sciencedirect.com/science/article/pii/S0014480021000150?via%3Dihub.
    Published • 10.1016/j.yexmp.2021.104616
  28. Morais, Mariana; Machado, Vera; Dias, Francisca; Palmeira, Carlos; Martins, Gabriela; Fonseca, Magda; Martins, Catarina S. M.; et al. "Starch-Capped AgNPs’ as Potential Cytotoxic Agents against Prostate Cancer Cells". Nanomaterials 11 2 (2021): 256. https://www.mdpi.com/2079-4991/11/2/256.
    Open access • Published • 10.3390/nano11020256
  29. Francisca Dias; Ana Luísa Teixeira; Inês Nogueira; Mariana Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study". International Journal of Molecular Sciences 21 13 (2020): 4624-4624. https://doi.org/10.3390/ijms21134624.
    10.3390/ijms21134624
  30. Francisca Dias; Ana Luísa Teixeira; Inês Nogueira; Mariana Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease". Cancers (2020): https://doi.org/10.3390/cancers12061450.
    10.3390/cancers12061450
  31. Morais, Mariana; Dias, Francisca; Resende, Telma; Nogueira, Inês; Oliveira, Jorge; Maurício, Joaquina; Teixeira, Ana Luísa; Medeiros, Rui. "Leukocyte telomere length and hTERT genetic polymorphism: influence in renal cell carcinoma clinical outcome". Future Oncology (2020):
    Published
  32. Mariana Morais; Francisca Dias; Ana Luísa Teixeira; Rui Medeiros. "Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney". Cancer Management and Research (2020): https://doi.org/10.2147/CMAR.S211225.
    Published • 10.2147/CMAR.S211225
  33. Morais, Mariana; Dias, Francisca; Teixeira, Ana Luísa; Medeiros, Rui. "

    Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney

    ". Cancer Management and Research Volume 12 (2020): 1669-1679. http://dx.doi.org/10.2147/cmar.s211225.
    10.2147/cmar.s211225
  34. Morais, M.; Teixeira, A.L.; Dias, F.; Machado, V.; Medeiros, R.; Prior, J.A.V.. "Cytotoxic Effect of Silver Nanoparticles Synthesized by Green Methods in Cancer". Journal of Medicinal Chemistry 63 23 (2020): 14308-14335. http://www.scopus.com/inward/record.url?eid=2-s2.0-85097874531&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.0c01055
  35. Morais, M.; Dias, F.; Resende, T.; Nogueira, I.; Oliveira, J.; Maurício, J.; Teixeira, A.L.; Medeiros, R.. "Leukocyte telomere length andhTERTgenetic polymorphism rs2735940 influence the renal cell carcinoma clinical outcome". Future Oncology 16 18 (2020): 1245-1255. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086525008&partnerID=MN8TOARS.
    10.2217/fon-2019-0795
  36. Nogueira I; Dias F; Morais M; Teixeira AL; Medeiros R. "Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2a as molecular triggers?". Future oncology (London, England) (2019): http://europepmc.org/abstract/med/31267758.
    10.2217/fon-2019-0067
  37. Dias, Francisca; Morais, Mariana; Teixeira, Ana; Medeiros, Rui. "Involving the microRNA Targetome in Esophageal-Cancer Development and Behavior". Cancers 10 10 (2018): 381. http://dx.doi.org/10.3390/cancers10100381.
    Published • 10.3390/cancers10100381
  38. Patrão AS; Dias F; Teixeira AL; Maurício J; Medeiros R. "XPO5 genetic polymorphisms in cancer risk and prognosis.". Pharmacogenomics (2018): http://europepmc.org/abstract/med/29790454.
    10.2217/pgs-2018-0018
  39. Nogueira I; Dias F; Teixeira AL; Medeiros R. "miRNAs as potential regulators of mTOR pathway in renal cell carcinoma.". Pharmacogenomics (2018): http://europepmc.org/abstract/med/29334302.
    10.2217/pgs-2017-0160
  40. Araújo R; Santos JMO; Fernandes M; Dias F; Sousa H; Ribeiro J; Bastos MMSM; et al. "Expression profile of microRNA-146a along HPV-induced multistep carcinogenesis: a study in HPV16 transgenic mice.". Journal of cancer research and clinical oncology (2017): http://europepmc.org/abstract/med/29181576.
    10.1007/s00432-017-2549-5
  41. Dias F; Teixeira AL; Ferreira M; Adem B; Bastos N; Vieira J; Fernandes M; et al. "Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma.". Oncotarget (2017): http://europepmc.org/abstract/med/29262564.
    10.18632/oncotarget.21733
  42. Dias, Francisca. "MicroRNAs and altered metabolism of clear cell renal cell carcinoma: Potential role as aerobic glycolysis biomarkers.". Biochimica et biophysica acta (2017): http://europepmc.org/abstract/med/28579513.
    10.1016/j.bbagen.2017.05.028
  43. Silva FV; Dias F; Costa G; Campos MD. "Chamomile reveals to be a potent galactogogue: the unexpected effect.". (2017): http://europepmc.org/abstract/med/28000519.
    10.1080/14767058.2016.1274300
  44. Adem, Bárbara Filipa; Bastos, Nuno Ricardo Alves; Dias, Francisca; Teixeira, Ana Luísa; Medeiros, Rui. "miRNAs: mediators of ErbB family targeted therapy resistance". Pharmacogenomics 17 10 (2016): 1175-1187. http://dx.doi.org/10.2217/pgs-2016-0038.
    Published • 10.2217/pgs-2016-0038
  45. Adem BF; Bastos NR; Dias F; Teixeira AL; Medeiros R. "miRNAs: mediators of ErbB family targeted therapy resistance.". (2016): http://europepmc.org/abstract/med/27359187.
  46. Machado MT; Navega S; Dias F; de Sousa MJ; Teixeira AL; Medeiros R. "microRNAs for peripheral blood fraction identification: Origin, pathways and forensic relevance.". (2015): http://europepmc.org/abstract/med/26522049.
    10.1016/j.lfs.2015.10.029
  47. Rosinha A; Assis J; Dias F; Nogueira A; Pereira D; Maurício J; Teixeira AL; Medeiros R. "DNA repair system and renal cell carcinoma prognosis: under the influence of NBS1.". (2015): http://europepmc.org/abstract/med/26493193.
    10.1007/s12032-015-0701-0
  48. Dias, F.; Teixeira, A.L.; Ribeiro, B.; Bastos, N.; Fernandes, M.; Sequeira, M.I.; Maurício, J.; et al. "229 Hypoxia modulation in Renal Cell Carcinoma by extracellular levels of miR-210 and miR-1233: Implications in time-to-disease progression". European Journal of Cancer 51 (2015): S36-S37. http://dx.doi.org/10.1016/s0959-8049(16)30116-2.
    Published • 10.1016/s0959-8049(16)30116-2
  49. Santos JI; Teixeira AL; Dias F; Gomes M; Nogueira A; Assis J; Medeiros R. "Restoring TGFß1 pathway-related microRNAs: possible impact in metastatic prostate cancer development.". (2014): http://europepmc.org/abstract/med/24763824.
    10.1007/s13277-014-1887-z
  50. Santos JI; Teixeira AL; Dias F; Maurício J; Lobo F; Morais A; Medeiros R. "Influence of peripheral whole-blood microRNA-7 and microRNA-221 high expression levels on the acquisition of castration-resistant prostate cancer: evidences from in vitro and in vivo studies.". (2014): http://europepmc.org/abstract/med/24760272.
    10.1007/s13277-014-1918-9
  51. Teixeira AL; Ferreira M; Silva J; Gomes M; Dias F; Santos JI; Maurício J; Lobo F; Medeiros R. "Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients.". (2014): http://europepmc.org/abstract/med/24379138.
    10.1007/s13277-013-1531-3
  52. Dias, Francisca. "Circulating biomarkers in renal cell carcinoma: the link between microRNAs and extracellular vesicles, where are we now?". Journal of Kidney Cancer and VHL (2014): http://jkcvhl.com/jkcv/index.php/jkcvhl/article/view/19.
    http://dx.doi.org/10.15586/jkcvhl.2014.19
  53. Teixeira AL; Dias F; Ferreira M; Gomes M; Santos JI; Lobo F; Maurício J; Machado JC; Medeiros R. "Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression.". (2014): http://europepmc.org/abstract/med/25909813.
    10.1371/journal.pone.0103258
  54. Dias F; Teixeira AL; Santos JI; Gomes M; Nogueira A; Assis J; Medeiros R. "Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway.". (2013): http://europepmc.org/abstract/med/24192126.
    10.2217/pgs.13.184
  55. Teixeira AL; Gomes M; Nogueira A; Azevedo AS; Assis J; Dias F; Santos JI; et al. "Correction: Improvement of a Predictive Model of Castration-Resistant Prostate Cancer: Functional Genetic Variants in TGFß1 Signaling Pathway Modulation.". (2013): http://europepmc.org/abstract/PMC/PMC3752013.
  56. Teixeira, A.L.; Gomes, M.; Nogueira, A.; Azevedo, A.S.; Assis, J.; Dias, F.; Santos, J.I.; et al. "Improvement of a Predictive Model of Castration-Resistant Prostate Cancer: Functional Genetic Variants in TGFß1 Signaling Pathway Modulation". PLoS ONE 8 8 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84881245194&partnerID=MN8TOARS.
    10.1371/journal.pone.0072419
Journal issue
  1. Dias, Francisca; Teixeira, Ana Luísa. "Circulating microRNAs as Biomarkers in Cancer Prognosis". Cancers (2023): https://www.mdpi.com/journal/cancers/special_issues/1LPLK1PUOL.
    Accepted • Invited editor
  2. Dias, Francisca; Teixeira, Ana Luísa; MEDEIROS, RUI. "Special Issue "Noncoding RNAs in Renal Cell Carcinoma Landscape"". Cancers (2021): https://www.mdpi.com/journal/cancers/special_issues/Noncoding_RNAs_RCC.
    Under revision • Invited editor
  3. Dias, Francisca; Teixeira, Ana Luísa; MEDEIROS, RUI. ""Noncoding RNAs in Renal Cell Carcinoma Landscape"". Cancers (2021): https://www.mdpi.com/journal/cancers/special_issues/Noncoding_RNAs_RCC.
    Published
Thesis / Dissertation
  1. Dias, Francisca. "Synergic effect of microRNAs and metalloproteinases derived from extracellular vesicles in the establishment of the metastatic niche in renal cell carcinoma". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2020. https://repositorio-aberto.up.pt/handle/10216/127932.
  2. Dias, Francisca. "Circulating MicroRNAs and Renal Cell Carcinoma". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2014. https://repositorio-aberto.up.pt/handle/10216/77513.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/21 Tiny Messengers, Big Impact: How extracellular vesicles are revolutionizing cancer care XIV In4Med - Medical and Scientific Congress
Associação de Estudantes de Medicina de Coimbra (NEM/AAC) (Coimbra, Portugal)
2021/06/17 THE POTENTIAL OF EXTRACELLULAR VESICLES CARGO AS MOLECULAR BIOMARKERS FOR CLEAR CELL RENAL CELL CARCINOMA PATIENTS’ MANAGEMENT XVII Congress if the Iberian Society of Cytometry – Virtual Edition
Iberian Society of Cytometry (Porto, Portugal)
2020/09/24 Vesículas extracelulares enriquecidas em hsa-miR-301a-3p e hsa-miR-1293 no carcinoma de células renais de células claras: potenciais biomarcadores de doença metastática 2º Encontro de Jovens Investigadores
Liga Portuguesa Contra o Cancro - Núcleo Regional do Norte (Porto, Portugal)
2019/11/29 mRNA TIMP1 derivado de vesículas extracelulares como biomarcador de agressividade no CCRcc 16º Congresso Nacional de Oncologia
Sociedade Portuguesa de Oncologia (Estoril, Portugal)
2019/02/22 Involving the microRNA Targetome in Esophageal-cancer development and behavior IPO-Porto ESTIMA Symposium
Instituto Português de Oncologia do Porto (Porto, Portugal)
2018/04/15 Renal cell carcinoma microenvironment modulation by exosome-derived microRNAs and metalloproteinases 3rd SYMPOSIUM OF THE MSc IN ONCOLOGY
Instituto Português de Oncologia do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09 - Current Unveiling the Role of EVs-derived miR-15b-5p, miR-1293 and miR-376a-3p in Clear Cell Renal Cell Carcinoma Progression
Supervisor of Vânia Catrina Moreira Dias
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/01 - Current MicroRNAs immune response profile to COVID-19 vaccine boost in cancer patients under active treatment
Co-supervisor of Tânia Rôlo Dias
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - Current Extracellular vesicles in feline mammary tumors
Co-supervisor of Hugo Corte-Real Vilhena
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - 2024/12/02 Extracellular Vesicles-derived MicroRNAs as Potential Therapeutic Targets in Renal Cell Carcinoma
Supervisor of Ângela Maria Amorim Alves
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/10/02 - 2023/12/12 Analysis of the extracellular vesicles’ cargo in the plasma of cancer patients undergoing antiCOVID-19 vaccination
Co-supervisor of Beatriz Ferreira Almeida
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2022/10/03 - 2023/11/03 Exploring the role of hypoxia-associated non-coding RNAs in Modulating the tumor microenvironment of prostate cancer
Co-supervisor of Ana Patrícia Martins
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/02/01 - 2023/07/14 Evaluation of the Impact of Genetic Polymorphisms in ACE2 and TMPRSS2 on the Susceptibility to SARS-CoV-2 Infection in Cancer Patients
Supervisor of Vânia Catrina Moreira Dias
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2021 - 2022/01/07 Characterization of the genetic polymorphisms VEZT rs10859871, FN1 rs1250248 and WNT4 rs7521902: potential biomarkers of endometriosis development
Co-supervisor of Carolina Maria Dias Martins
 Mestrado Integrado em Medicina (Master)
Universidade do Minho Escola de Medicina, Portugal
2021 - 2021/10/20 Caracterização dos polimorfismos genéticos CYP2R1 rs2060793 e CYP2R1 rs 12794714: Potenciais biomarcadores na predisposição de Endometriose
Co-supervisor of Tatiana Nunes Varandas
 Análises Clínicas e Saúde Pública (Master)
Instituto Politécnico do Porto, Portugal
2021/02 - 2021/07 O Efeito de Warburg no processo de aquisição de resistência à terapia hormonal em células de Cancro da Próstata
Co-supervisor of Inês Maria Amorim Tavares
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/07 Estudo da Influência dos polimorfismos genéticos GEMIN4 rs7813 e rs2740348 no desenvolvimento do Carcinoma de Células Renais
Supervisor of Tânia Rolo Dias
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2018 - 2019 miRNAs como biomarcadores do ritmo circadiano
Co-supervisor of Joana Raquel Rodrigues Pinto
 Medicina Legal (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018/11/26 Perfil de microRNAs: Potenciais biomarcadores de identificação de amostras biológicas
Co-supervisor of Andreia Filipa Carvalho Ribeiro
 Medicina Legal (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2018/07/05 MicroRNA-101 as a potential regulator of mTORC2 and HIF-2a in renal cell carcinoma
Co-supervisor of Inês Cristiana Martins Nogueira
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2017/12/07 GLUT-1 related microRNAs and glycolysis in clear cell renal cell carcinoma
Co-supervisor of Mariana Gomes Morais
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2016/12/19 GE11 positive exosomes as a potential RNAi delivery system in clear cell renal cell carcinoma
Co-supervisor of Bárbara Filipa Adem Ribeiro
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2016/12/19 MicroRNAs: mediators of EGFR targeted therapy resistance in renal cell carcinoma
Co-supervisor of Nuno Ricardo Alves Bastos
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/11/24 - 2023/11/24 Dia Aberto CI-IPOP da Semana da Ciência & Tecnologia 2023 (2023/11/24 - 2023/11/24)
Other (Member of the Organising Committee)
 Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2022/12/14 - 2022/12/14 Understanding COVID-19 impact in cancer patients: The ONCOVAC project (2022/12/14 - 2022/12/14)
Symposium (Member of the Organising Committee)
 Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/04/10 - 2023/04/20 EATRIS-Plus Summer School in Personalised Medicine
Other
 EATRIS-Plus Summer School in Personalised Medicine
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2021/10/14 - 2021/10/15 ASPIC-ASEICA International Meeting - Current Trends in Precision medicine in Cancer
Congress
 ASPIC-ASEICA International Meeting - Current Trends in Precision medicine in Cancer
Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2021/05/07 - 2021/05/07 XXVI Workshop de Urologia Oncológica
Symposium
 XXVI Workshop de Urologia Oncológica
Grupo Português Génito-Urinário, Portugal
2020/09/24 - 2020/09/24 Participação no 2º Encontro de Jovens Investigadores
Congress
 2º Encontro de Jovens Investigadores
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2019/11/28 - 2019/11/30 16º Congresso Nacional de Oncologia
Congress
 16º Congresso Nacional de Oncologia
Sociedade Portuguesa de Oncologia, Portugal
2019/10/12 - 2019/10/12 Curso Imunoterapia no Carcinoma de Células Renais metastizado
Congress
 Curso Imunoterapia no Carcinoma de Células Renais metastizado
Grupo Português Génito-Urinário, Portugal
2019/09/27 - 2019/09/27 Extracellular Vesicles Workshop
Congress
 Extracellular Vesicles Workshop
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2019/09/24 - 2019/09/24 Participação no 1º Encontro de Jovens Investigadores
Congress
 1º Encontro de Jovens Investigadores
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2019/05/17 - 2019/05/18 XXIV WORKSHOP UROLOGICAL ONCOLOGY - III MULTIDISCIPLINARY GENITOURINARY COURSE. This course has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 12 European CME credits (ECMEC®s).
Workshop
 XXIV Workshop Urological Oncology – III Multidisciplinary genitourinary course
Grupo Português Génito-Urinário, Portugal
2018/11/09 - 2018/11/10 3º Congresso Nacional de Prevenção Oncológica e Direitos dos Doentes
Congress
 3º Congresso Nacional de Prevenção Oncológica e Direitos dos Doentes
Liga Portuguesa Contra o Cancro, Portugal
2017/07/07 - 2017/07/07 1st Precision Medicine in immuno-oncology meeting
Conference
 1st Precision Medicine in immuno-oncology meeting
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2017/05/11 - 2017/05/12 Participação no XXIV Porto Cancer Meeting - Liquid Biopsy: bringing Precision Medicine closer to Oncology
Congress
 XXIV Porto Cancer Meeting - Liquid Biopsy: bringing Precision Medicine closer to Oncology
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/09/25 - 2016/09/29 Participação no 8th ECCO - 40th ESMO European Cancer Congress
Congress
 8th ECCO - 40th ESMO European Cancer Congress
2016/04/28 - 2016/04/29 Participação no 2nd ASPIC International Congress
Congress
 2nd ASPIC International Congress
Associação Portuguesa de Investigação em Cancro (ASPIC), Portugal
2014/11/14 - 2014/11/16 Participação no 13º Congresso Nacional de Oncologia
Congress
 13º Congresso Nacional de Oncologia
Sociedade Portuguesa de Oncologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/20 Perfil genómico de atletas e ex-atletas de alto rendimento desportivo
(Thesis) Main arguer
 Hugo Henrique Santos Silva (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/12/02 Extracellular vesicles-derived microRNAs as potential therapeutic targets in Renal Cell Carcinoma
Supervisor
 Ângela Maria Amorim Alves (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/04/26 Silver Nanoparticles meet Prostate Cancer cells: nanomedicine applied to treatment optimization and its effects on microRNAs' dynamic
(Thesis) Arguer
 Mariana Gomes Morais (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021 - Current International Journal of Molecular Sciences (1442-0067) MDPI
2021 - Current Biomedicines (2227-9059) MDPI
2021 - Current Metabolites (2218-1989) MDPI
2021 - Current Biomolecules (2218-273X) MDPI
2021 - Current BMC cancer (1471-2407) Springer Nature SNAPP
2021 - Current Scientific Reports (2045-2322) Springer Nature SNAPP
2021 - Current BMC Urology (1741-2490, ) Springer Nature SNAPP
2021 - Current Cancer Management and Research (1179-1322,) Dove Press
2021 - Current International Journal of General Medicine (1178-7074) Dove Press
2021 - Current Research and Reports in Urology (2253-2447) Dove Press
2020 - Current Cancers (2072-6694) MDPI
2020 - Current Diagnostics ( 2075-4418) MDPI
2019 - Current OncoTargets and Therapy (1178-6930) Dove Medical Press

Conference scientific committee

Conference name Conference host
2024/07/12 - 2024/08/17 iMed Conference 16.0 NOVA Medical School
2023/09/23 - 2023/09/23 5º Encontro Nacional de Jovens Investigadores em Oncologia Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
2022/09/24 - 2022/09/24 4º Encontro Nacional de Jovens Investigadores em Oncologia Liga Portuguesa Contra o Cancro Núcleo Regional do Norte

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Leitura e Escrita Científica Medicina (Mestrado integrado) Universidade Fernando Pessoa, Portugal
2023/11/08 - 2023/11/08 Citopatologia I - Investigação Clínica, percurso pessoal, desafios e perspetivas futuras na área da Biologia Celular e Molecular Ciências Biomédicas Laboratoriais (Licenciatura) Instituto Politécnico de Bragança Escola Superior de Saúde de Bragança, Portugal
2023/11/03 - 2023/11/03 Investigação Científica em Ciências da Saúde Medicina Legal (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/10 - 2023/10 2ª Edição do Curso de Oncobiologia - Oncogenes and tumor suppressor genes Oncobiologia (Outros) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021 - 2022 Epigenetics Formação Avançada Pós-Universitária em Oncologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021 - 2022 Translational Research in Oncology Formação Avançada Pós-Universitária em Oncologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021 - 2022 Scientific research engines and databases Formação Avançada Pós-Universitária em Oncologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021 - 2022 Presentation and discussion of a scientific project Formação Avançada Pós-Universitária em Oncologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021/10/21 - 2021/10/21 Citopatologia I - Biologia e Etiologia do Cancro Ciências Biomédicas Laboratoriais Instituto Politécnico de Bragança, Portugal
2020 - 2021/02 Cancer Biology and Etiology Formação Avançada Pós-Universitária em Oncologia (Pós-Graduação) Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2017/07/10 - 2017/07/21 Porque somos todos diferentes?... Da célula normal à célula tumoral! Universidade Júnior Universidade do Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022/07/22 - 2022/07/22 Opponent in the evaluation committee of Patrícia Torre, BSc student from Faculty of Sciences of University of Porto (FCUP), that concluded her degree in Biochemistry with the public defense of the project “Non-Coding RNAs as Biomarkers for Prostate Cancer”.
Evaluator
 Universidade do Porto Faculdade de Ciências, Portugal

Interview (tv / radio show)

Program Topic
2023/10/14 - 2023/10/14 5ª Gala Solária IPO-Porto Vídeo dos 50 anos IPO-Porto (minuto 1:37)
2018/03/24 - 2018/03/24 Bom dia Portugal Fim de Semana (Parte 1, minuto 29:20) Aplicabilidade da medicina personalizada no estudo do cancro do Rim
2015/05/23 - 2015/05/23 Bom dia Portugal (Parte 1, minuto 31:44) Obesidade e Cancro
Distinctions

Award

2014 Merit Scholarship Award
Direção-Geral do Ensino Superior (DGES), Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Other distinction

2015 Research Fellowship for Oncology Research
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal