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Carlos André Viegas Barreto. Completed the Mestrado in Mestrado em Biologia Celular e Molecular in 2018/09/17 by Universidade de Coimbra Departamento de Ciências da Vida and Licenciatura in Licenciatura em Ciências Biomédicas in 2016/06/28 by Universidade de Aveiro. Attends the Doutoramento in Doctoral Programme in Experimental Biology and Biomedicine by Universidade de Coimbra Instituto de Investigação Interdisciplinar since 2019/10/10. Is PhD Student in Universidade de Coimbra Centro de Neurociências e Biologia Celular. Published 10 articles in journals. Has 3 section(s) of books. Organized 6 event(s). Participated in 12 event(s). Has received 5 awards and/or honors. Participates and/or participated as Master Student Fellow in 1 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry. In their professional activities interacted with 119 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Inteligência artificial; design computacional e descoberta de fármacos; vias de sinalização; algoritmos de previsão em tempo real; .
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Identification

Personal identification

Full name
Carlos André Viegas Barreto
Date of birth
1995/12/09
Gender
Male

Citation names

  • Barreto, Carlos A.V.

Author identifiers

Ciência ID
8712-93FE-685B
ORCID iD
0000-0003-1459-7680
Google Scholar ID
SlpPtEoAAAAJ&hl
Researcher Id
F-3995-2018

Email addresses

  • cbarreto@cnc.uc.pt (Professional)

Telephones

Mobile phone
  • 910720653 (Personal)

Addresses

  • Estrada de São Bernardo 189 1º Esquerdo, 3810-175, Aveiro, Aveiro, Portugal (Personal)

Websites

  • carlosavbarreto.github.io (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2019/10/10 - 2024
Ongoing
 Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016/08/02 - 2018/09/17
Concluded
 Mestrado em Biologia Celular e Molecular (Mestrado)
Major in Sem especialização
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Applying computational tools to the study of GPCRs structure and dynamics" (THESIS/DISSERTATION)
 18
2013/09/12 - 2016/06/28
Concluded
 Licenciatura em Ciências Biomédicas (Licenciatura)
Major in Menor em Biomedicina Molecular
Universidade de Aveiro, Portugal
"n/a" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2023/02/01 - 2023/05/31 Visiting Researcher (Research) Icahn School of Medicine at Mount Sinai, United States
Icahn School of Medicine at Mount Sinai, United States
2019/01/21 - 2019/10/31 Research Trainee (Research) CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
2019/11/01 - Current PhD Student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/01 - 2018/09/15 Master's Student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
CNC - Data Driven Molecular Design Group, Portugal
2018/04/03 - 2018/05/18 Visiting Student, under the grant from HPC Europa3 Programme Universiteit Utrecht, Netherlands
2017/05/02 - 2017/05/26 Trainee, under Laboratory Rotation from Master's Program Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/04/03 - 2017/04/28 Trainee, under Laboratory Rotation from Master's Program Universidade de Lisboa Faculdade de Ciências, Portugal
2017/01/30 - 2017/02/24 Trainee, under Laboratory Rotation from Master's Program Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/07/11 - 2016/07/31 Trainee Universidade de Aveiro Instituto de Biomedicina, Portugal
2015/01/01 - 2016/05/31 Voluntariado Unidade de Cuidados Continuados da Santa Casa da Misericórdia de Ílhavo, Portugal
Projects

Contract

Designation Funders
2021/02/01 - 2024/01/31 Descoberta do Interactoma vírus-hospedeiro: uma abordagem guiada por AI e dados multi-ómicos <br>
DSAIPA/DS/0118/2020
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/21 - 2019/10/31 Membrane proteins - development of new computational approaches and its application to G-protein Coupled Receptors
PTDC/QUI-OUT/32243/2017
Master Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Preto, A.J.; Marques-Pereira, C; Baptista, Salete J.; Bueschbell, B.; Barreto, Carlos A.V.; Gaspar, A.T.; Pinheiro, I.; et al. "Targeting GPCRs Via Multi-Platform Arrays and AI". In Comprehensive Pharmacology, 135-162. Elsevier, 2022.
    Published • 10.1016/b978-0-12-820472-6.00048-7
  2. Barreto, Carlos A.V.; Baptista, Salete J.; Bueschbell, Beatriz; Magalhães, Pedro; Preto, António; Lemos, Agostinho; Rosário-Ferreira, Nicia; et al. "Arrestin and G Protein Interactions with GPCRs: A Structural Perspective". In GPCRs as Therapeutic Targets. 2022.
    Published • 10.1002/9781119564782.ch5
  3. Barreto, Carlos A.V.; Baptista, Salete J.; Preto, António José; Matos-Filipe, Pedro; Mourão, Joana; Melo, Rita; Moreira, Irina. "Prediction and targeting of GPCR oligomer interfaces". In Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, 105-149. Elsevier, 2020.
    10.1016/bs.pmbts.2019.11.007
Conference paper
  1. Barreto, Carlos; Machuqueiro, Miguel; Bonvin, Alexandre; Moreira, Irina; Barreto, Carlos A.V.; Moreira IS. "Structural and dynamic understanding of the ghrelin receptor high constitutive activity". Paper presented in MOL2NET 2017, 2017.
    10.3390/mol2net-03-05089
  2. Bueschbell, Beatriz; Preto, António; Barreto, Carlos; Schiedel, Anke; Moreira, Irina. "Creating a valid in silico Dopamine D2-receptor model for small molecular docking studies". Paper presented in MOL2NET 2017, 2017.
    10.3390/mol2net-03-05088
Conference poster
  1. Caniceiro, Ana B.; Bueschbell, Beatriz; Preto, António J.; Barreto, Carlos A.V.; Moreira, Irina S.. "MUG Database: mutational landscape of GPCR subfamily A17 receptors". Paper presented in BioExcel Summer School 2023, 2023.
  2. Caniceiro, A. B.; Büschbell, Beatriz; Preto, A.J.; Barreto, Carlos A.V.; Moreira, I.S.. "MUTPROT database: a mutation overview of GPCR sub-family A17 receptors". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2021.
  3. Gouveia, R. P.; Barreto, Carlos A.V.; Baptista, Salete J.; Preto, A.J.; Caldeira, Gladys Lima; Carvalho, Ana Luisa; Melo, Rita; Irina de Sousa Moreira. "The study of AMPAR: Stargazin interface through molecular dynamics". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2021.
  4. Caldeira, Gladys Lima; Inácio, Ângela S.; Beltrão, Nuno; Barreto, Carlos A.V.; Ventura Rodrigues, Marina; Rondão, Tiago; Macedo, Renato; et al. "Aberrant hippocampal transmission and behavior in mice with stargazin mutation linked to intellectual disability.". Paper presented in SPN2021, 2021.
  5. Ventura Rodrigues, Marina; Inácio, Ângela S.; Caldeira, Gladys Lima; Gouveia, Raquel P; Barreto, Carlos A.V.; Beltrão, Nuno; Moreira, Irina S; Taglialatela, Maurizio; Carvalho, Ana Luisa. "Stargazin as a Regulator of Neuronal Excitability". Paper presented in SPN2021, 2021.
  6. Barreto, Carlos A.V.; Salete J. Baptista; Antonio José Preto; Daniel Silvério; Rita Melo; Irina S. Moreira. "Decoding Partner Specificity in Opioid Receptor Family". Paper presented in Bioinformatics Open Days, 2021.
  7. Gouveia, Raquel; Barreto, Carlos A.V.; Baptista, Salete J.; Caldeira, Gladys Lima; Preto, A.J.; Melo, Rita; Carvalho, Ana Luisa; Moreira, Irina S. "The Structural and Functional Role of a CACNG2 Mutation in Psychiatric Disorders". Paper presented in Bioinformatics Open Days, 2021.
  8. Barreto, Carlos A.V.; Melo, Rita; Magalhães, Pedro R.; Renault, Pedro; Machuqueiro, Miguel; Moreira, Irina S.. "Understanding Structural and Dynamic Differences of GHSR-Gq nad GHSr-Arr Complexes". Paper presented in Encontro Jovens Investigadores de Biologia Estrutural e Computacional, 2018.
Journal article
  1. Caniceiro, Ana B.; Bueschbell, Beatriz; Barreto, Carlos A.V.; Preto, António J.; Moreira, Irina S.. "MUG: A mutation overview of GPCR subfamily A17 receptors". Computational and Structural Biotechnology Journal 21 (2023): 586-600. http://dx.doi.org/10.1016/j.csbj.2022.12.031.
    10.1016/j.csbj.2022.12.031
  2. Bueschbell, Beatriz; Magalhães, Pedro R.; Barreto, Carlos A.V.; Melo, Rita; Schiedel, Anke C.; Machuqueiro, Miguel; Moreira, Irina S.. "The World of GPCR dimers – Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements". Computational and Structural Biotechnology Journal 21 (2023): 4336-4353. http://dx.doi.org/10.1016/j.csbj.2023.08.032.
    10.1016/j.csbj.2023.08.032
  3. Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): http://dx.doi.org/10.1038/s41380-022-01487-w.
    10.1038/s41380-022-01487-w
  4. Nícia Rosário-Ferreira; Salete J. Baptista; Carlos A. V. Barreto; Filipe E. P. Rodrigues; Tomás F. D. Silva; Sara G. F. Ferreira; João N. M. Vitorino; et al. "In Silico End-to-End Protein–Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2". ACS Synthetic Biology (2021): https://doi.org/10.1021/acssynbio.1c00368.
    10.1021/acssynbio.1c00368
  5. Barreto, Carlos A.V.. "Decoding Partner Specificity of Opioid Receptor Family". Frontiers in Molecular Biosciences 8 (2021): http://dx.doi.org/10.3389/fmolb.2021.715215.
    10.3389/fmolb.2021.715215
  6. A. J. Preto; Carlos A. V. Barreto; Salete J. Baptista; José Guilherme de Almeida; Agostinho Lemos; André Melo; M. Nátalia D. S. Cordeiro; et al. "Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family". Journal of Chemical Information and Modeling (2020): https://doi.org/10.1021/acs.jcim.0c00371.
    10.1021/acs.jcim.0c00371
  7. Carolina Gomes; Diana Ferreira; João P. F. Carvalho; Carlos A. V. Barreto; Joana Fernandes; Marisol Gouveia; Fernando Ribeiro; Ana S. Duque; Sandra I. Vieira. "Current genetic engineering strategies for the production of antihypertensive ACEI peptides". Biotechnology and Bioengineering (2020): https://doi.org/10.1002/bit.27373.
    10.1002/bit.27373
  8. Beatriz Bueschbell; Carlos Barreto; António J. Preto; Anke Schiedel; Irina Moreira. "A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods". Molecules (2019): https://www.mdpi.com/1420-3049/24/7/1196.
    10.3390/molecules24071196
  9. Melo R; Lemos A; Preto AJ; Bueschell B; Matos-Filipe P; Barreto C; Almeida JG; et al. "An overview of antiretroviral agents for treating HIV infection in paediatric population.". Current medicinal chemistry (2018): http://europepmc.org/abstract/med/30182840.
    10.2174/0929867325666180904123549
  10. Schiedel AC; Kose M; Barreto C; Bueschbell B; Morra G; Sensoy O; Moreira IS. "Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers.". Current topics in medicinal chemistry (2018): http://europepmc.org/abstract/med/29866008.
    10.2174/1568026618666180604082610
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/21 MODELLER Worskop Computational Structural Biology Tools Workshop
Biodata.pt; ELIXIR-PT (Coimbra, Portugal)
2021/12/20 DRD2 homo-dimers – a world of possibilities 8th Meeting of Young Researchers in Structural Computational Biology
(Coimbra, Portugal)
2019/02/25 Applying Computational Tools to the Study of GPCRs Structures and Dynamics Advanced Course in COMPUTATIONAL BIOLOGY
PhD Programme in EXPERIMENTAL BIOLOGY AND BIOMEDICINE at CNC (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/12/01 - 2023/12/31 3D-Bioinfo-PT Intermediate Workshop (2023/12/19)
Workshop (Member of the Organising Committee)
2023/12/01 - 2023/12/31 3D-Bioinfo-PT Annual Meeting (2023/12/18)
Meeting (Member of the Organising Committee)
2023/10/01 - 2023/10/31 3D-Bionfo-PT Introductory Workshop (2023/10/20)
Workshop (Member of the Organising Committee)
2023/06/01 - 2023/06/30 3D-Bioinfo-PT Advanced Workshop (2023/06/15 - 2023/06/16)
Workshop (Member of the Organising Committee)
2021/06/01 - 2022/01/19 Member of the Organizing Committee of BEB Day 2022 - The Overview Effect (2022/01/18 - 2022/01/19)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/12 - 2017/12 Member of Organizing Committee Encontro de Jovens Investigadores em Biologia Computacional e Estrutural - Edição 2017 (2017/12 - 2017/12)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/09/09 - 2021/09/10 GROMACS workshop: a collaboration between BioExcel and national eurohpc competence center
Workshop
 GROMACS workshop: a collaboration between BioExcel and national eurohpc competence center
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/04/12 - 2021/04/14 4th ERNEST Conference
Conference
 4th ERNEST Conference
European Research Network on Signal Transduction , Germany
2019/01/25 - 2019/01/25 Encontro sobre Estratégias Inteligentes para Química Computacional
Meeting
Universidade de Coimbra Departamento de Química, Portugal
2018/12/21 - 2018/12/21 Encontro de Jovens Investigadores de Biologia Computacional e Estrutural 2018
Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2018/04/23 - 2018/04/23 2018 Bijvoet Tutorial Symposium
Symposium
Bijvoet Center, Netherlands
2017/12/22 - 2017/12/22 Encontro de Jovens Investigadores de Biologia Computacional e Estrutural 2017
Meeting
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/11/25 - 2017/11/25 Mind Your Data
Conference
Junior Enterprise for Science and Technology (JEST), Portugal
2017/09/04 - 2017/09/14 2017 Summer School in Computational Biology - from molecules to tissues
Universidade de Coimbra, Portugal
2017/03/29 - 2017/03/31 Glisten Symposium
Symposium
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/04/01 - 2015/06/30 Programa Municipal "Vocação". Integrei a equipa do Gabinete de Comunicação e Imagem da Câmara Municipal de Ílhavo.
Other
Câmara Municipal de Ílhavo, Portugal
2015/03/12 - 2015/03/14 VI Jornadas Nacionais de Ciências Biomédicas
Meeting
Universidade do Algarve, Portugal
2013/07/01 - 2013/07/31 Programa Municipal de Ocupação de Tempos Livres. Integrei a equipa do Gabinete de Ação Social da Câmara Municipal de Ílhavo
Other
Câmara Municipal de Ílhavo, Portugal

Mentoring / Tutoring

Topic Student name
2021/05/01 - 2021/05/31 Daily co-Advisor of Master Student's Rotation Guilherme Gabrial
2019/09 - 2019/09 Structural Modeling and Molecular Docking Computational Biology Summer School selected students (1)
2019/02 - 2019/02 Daily co-Advisor of Master Student's Rotation Raquel Gouveia
2014/09/24 - 2015/07/15 Mentor on Programa de Tutoria UA Vários Alunos
Distinctions

Award

2023 FLAD R&D @ USA Grant 2023
Fundação Luso-Americana para o Desenvolvimento, Portugal
2022 Fulbright Grant for Research with the support of FCT, AY2022/2023
Fulbright Portugal, Portugal
2019 Bolsa de Investigação para Mestre
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 FCT PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2018 Grant from HPC Europa3 Programme (730897)