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André L. Simão earned his PhD in Pharmacy from iMed.ULisboa/FFUL in 2019, focusing on mitochondria-targeting microRNAs and their role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD), as well as their therapeutic potential in liver and skeletal muscle. He subsequently pursued postdoctoral research on the role of microRNA-containing extracellular vesicles (EVs), released from adipose tissue, during MASLD pathogenesis and their potential as key mediators of inter-tissue communication. During the COVID-19 pandemic, Simão conducted a multicenter European study assessing the humoral immune response of two-dose COVID-19 vaccines among patients with different hepatic aetiologies from six different EU countries. In 2023, he began the MSc in Computational Biology and Bioinformatics, specializing in Multi-Omics, at Universidade NOVA de Lisboa. Currently, he holds a UEG Research Fellowship at Biogipuzkoa HR Institute in San Sebastian, Spain. Simão has authored 14 peer-reviewed papers and 2 book chapters achieving an h-index of 12. He (co)-supervises 5 master, 2 PhD, and several undergraduate students and has served as a member and examiner of several master’s thesis juries. Additionally, he has been an integral part of 8 funded research projects (2 as PI).
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Identification

Personal identification

Full name
André Daniel Lopes Simão

Author identifiers

Ciência ID
8718-8151-41E0
ORCID iD
0000-0002-5986-1089
Researcher Id
M-9767-2018
Scopus Author Id
56041784600

Websites

Education
Degree Classification
2023/09/01 - 2025
Ongoing
 Biologia Computacional e Bioinformática (Mestrado)
Major in Multi-Omics for Life and Health Sciences
Universidade Nova de Lisboa, Portugal
2015/01/01 - 2019/09/23
Concluded
 Farmácia (Doutoramento)
Major in Cellular and Molecular Biology
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Role of Mitochondria-Targeting miRNAs in Non-Alcoholic Fatty Liver Disease" (THESIS/DISSERTATION)
 Approved with Distinction and Honors
2008 - 2013
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"miRNAs in Liver Diseases" (THESIS/DISSERTATION)
 16 in 20 (300 ECTS)
Outputs

Publications

Book chapter
  1. Simão, André L.; Borralho, Pedro M.; Steer, Clifford J.; Castro, Rui E.; Rodrigues, Cecília M. P.. "Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of miRNA and Protein Expression". In Methods in Molecular Biology, 1-15. Springer US, 2021.
    10.1007/978-1-0716-1433-4_1
  2. Rodrigues PM.; Lapitz A.; Simão AL.; Perugorria MJ.; Arrese M.; Castro RE.; Bañales JM.. "Extracellular Vesicles in Non-alcoholic Fatty Liver Disease: Key Players in Disease Pathogenesis and Promising Biomarker Tools". 2020.
    10.1007/978-3-030-37173-9_9
Journal article
  1. Rodriguez-Agudo, Ruben; Gonzalez-Recio, Irene; Serrano-Macia, Marina; Bravo, Miren; Petrov, Petar; Blaya, Delia; Herranz, Jose Maria; et al. "Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1". JHEP Reports (2024): https://doi.org/10.1016/j.jhepr.2023.100918.
    10.1016/J.JHEPR.2023.100918
  2. Pedro M. Rodrigues; Marta B. Afonso; Simão AL.; Tawhidul Islam; Maria M. Gaspar; Colm J. O'Rourke; Monika Lewinska; et al. "miR-21-5p promotes NASH-related hepatocarcinogenesis". Liver International (2023): https://doi.org/10.1111/liv.15682.
    10.1111/liv.15682
  3. Simão AL.; Palma, Carolina Santos; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease". JHEP Reports (2023): 100697. http://dx.doi.org/10.1016/j.jhepr.2023.100697.
    10.1016/j.jhepr.2023.100697
  4. Macias, Rocio I.R.; Monte, Maria J.; Serrano, Maria A.; González-Santiago, Jesús M.; Martín-Arribas, Isabel; Simão, André L.; Castro, Rui E.; et al. "Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics". Aging 13 19 (2021): 23416-23434. http://dx.doi.org/10.18632/aging.203620.
    10.18632/aging.203620
  5. Tudor Mocan; André L. Simão; Rui E. Castro; Cecília M. P. Rodrigues; Artur Slomka; Bingduo Wang; Christian Strassburg; et al. "Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?". Journal of Clinical Medicine 9 5 (2020): 1541-1541. https://doi.org/10.3390/jcm9051541.
    10.3390/jcm9051541
  6. Afonso, M.B.; Rodrigues, P.M.; Mateus-Pinheiro, M.; Simão, A.L.; Gaspar, M.M.; Majdi, A.; Arretxe, E.; et al. "RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease". Gut (2020): https://gut.bmj.com/content/70/12/2359.
    10.1136/gutjnl-2020-321767
  7. Simão, A.L.; Afonso, M.B.; Rodrigues, P.M.; Gama-Carvalho, M.; Machado, M.V.; Cortez-Pinto, H.; Rodrigues, C.M.P.; Castro, R.E.. "Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis". Journal of Molecular Medicine 97 8 (2019): 1113-1126. https://link.springer.com/article/10.1007/s00109-019-01796-8.
    10.1007/s00109-019-01796-8
  8. Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Gaspar, M.M.; Carvalho, T.; Borralho, P.; Bañales, J.M.; Castro, R.E.; Rodrigues, C.M.P.. "MiRNA-21 ablation protects against liver injury and necroptosis in cholestasis". Cell Death and Differentiation 25 5 (2018): 857-872. https://www.nature.com/articles/s41418-017-0019-x.
    10.1038/s41418-017-0019-x
  9. Rodrigues, P.M.; Afonso, M.B.; Carvalho, C.C.; Trindade, A.; Duarte, A.; Borralho, P.M.; MacHado, M.V.; et al. "MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice". Cell Death and Disease 8 4 (2017): https://www.nature.com/articles/cddis2017172.
    10.1038/cddis.2017.172
  10. Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Ofengeim, D.; Carvalho, T.; Amaral, J.D.; Gaspar, M.M.; et al. "Activation of necroptosis in human and experimental cholestasis". Cell Death and Disease 7 9 (2016): https://www.nature.com/articles/cddis2016280.
    10.1038/cddis.2016.280
  11. Afonso MB; Rodrigues PM; Simão AL; Castro RE. "Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma.". (2016): http://europepmc.org/abstract/med/26950158.
    10.3390/jcm5030030
  12. Rodrigues, P.M.; Afonso, M.B.; Simão, A.L.; Borralho, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis". Scientific Reports 5 (2015): https://www.nature.com/articles/srep17528.
    10.1038/srep17528
  13. Ferreira, D.M.S.; Simão, A.L.; Rodrigues, C.M.P.; Castro, R.E.. "Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease". FEBS Journal 281 11 (2014): 2503-2524. https://doi.org/10.1111/febs.12806.
    10.1111/febs.12806
  14. Ferreira, D.M.S.; Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Pereira, D.M.; Borralho, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "c-jun N-terminal kinase 1/c-jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver". Molecular and Cellular Biology 34 6 (2014): 1100-1120. https://doi.org/10.1128/MCB.00420-13.
    10.1128/MCB.00420-13