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Duarte Barral (DB) is a tenured Associate Professor with Habilitation at NMS-UNL, with over two decades of expertise in investigating the mechanisms underlying membrane trafficking in both health and disease contexts. DB earned his Degree in Microbiology and Genetics from the Faculty of Sciences of the University of Lisbon in 1997, followed by a PhD in Cell Biology from Imperial College London in 2003. He then ventured into the field of immunology, undertaking a Post-Doctoral Fellow position (2003) at Brigham and Women's Hospital, Harvard Medical School. In 2009, DB became a Principal Investigator (PI) at NMS-UNL, where he established the Membrane Traffic in Disease group, which has made significant contributions to the fields of molecular cell biology, skin pigmentation, and oncobiology. Before attaining his current position, through an international competitive selection process, DB secured his own salary for 19 years through several competitive calls: undergraduate, PhD and Post-Doctoral fellowships, as well as Principal Investigator contracts (Ciência 2008 and FCT Investigator, both funded by Fundação para a Ciência e a Tecnologia – FCT). Such achievements underscore his exceptional academic profile. DB’s research aims to unravel the regulatory roles of GTPases belonging to the Rab and Arf families in the trafficking of lysosomes and lysosome-related organelles such as melanosomes, and elucidating how dysregulation of these processes contributes to human diseases, notably cancer. Indeed, DB has helped uncover the previously unknown role of several of these proteins, namely Rab27a (Stinchcombe et al., J Cell Biol., 2001; Hume et al., Traffic, 2002; Barral et al., J Clin. Invest., 2002), Rab35 (Kuhns et al., EMBO Rep., 2019), Arl8b (Garg et al, Immunity, 2011), and Arl13b (Barral et al., PNAS, 2012; Casalou et al., J. Cell Sci., 2014; Casalou et al., Cancers, 2019). The latter reported a novel role for Arl13b in the regulation of breast cancer cell migration and invasion. DB has demonstrated a remarkable ability to secure competitive funding, amassing over 2.75 million € for research projects as PI/Coordinator, and in successfully overseeing the completion of 10 funded projects. These projects received national funding, including from FCT and Liga Portuguesa Contra o Cancro – LPCC, as well as from international sources, namely the European Commission. He also has a solid and consistent track record of publishing impactful studies, with 52 publications in peer-reviewed international journals and 3007 citations (h-index 30).
Identification

Personal identification

Full name
Duarte Barral

Citation names

  • Barral, Duarte C.

Author identifiers

Ciência ID
8810-DEBC-025E
ORCID iD
0000-0001-8867-2407
Google Scholar ID
oH8Y9bYAAAAJ&hl
Researcher Id
E-7548-2013
Scopus Author Id
6602513159

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences
Education
Degree Classification
2023/04/27 - 2023/04/28
Concluded
Health Sciences - Biomedicine (Título de Agregado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003/09/30
Concluded
PhD (Doctor of Philosophy)
Imperial College London, United Kingdom
"Expression, Localisation and Function of Rab27 Proteins" (THESIS/DISSERTATION)
N/A
1997/07/16
Concluded
Microbiology and Genetics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Towards the identification of the Schwartz-Jampel Syndrome gene" (THESIS/DISSERTATION)
17 (0-20)
Affiliation

Science

Category
Host institution
Employer
2009/07/01 - 2020/05/31 Contracted Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2003/10/10 - 2008/10/14 Postdoc (Research) Brigham and Women's Hospital Department of Medicine, United States

Teaching in Higher Education

Category
Host institution
Employer
2020/06/01 - Current Associate Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012/11/01 - 2020/05/31 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006/09 - 2008/07 Tutor (University Teacher) Harvard Medical School, United States

Others

Category
Host institution
Employer
2008/10/15 - 2009/06/30 Instructor in Medicine Harvard Medical School, United States
1999/10/01 - 2003/09/30 PhD student Imperial College London, United Kingdom
1997/10/01 - 1999/09/30 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1996/10/01 - 1997/06/30 ERASMUS student Université Paris Diderot, France
Hôpital Universitaire Pitié Salpêtrière, France
Projects

Grant

Designation Funders
2022/04 - 2024/03 Targeting lysosome exocytosis to impair breast cancer progression and metastasis. PI, total budget = 15,000€
N/A - LPCC
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Liga Portuguesa Contra o Cancro
Concluded
2018/10 - 2022/06 Molecular mechanisms of melanin internalization and processing by keratinocytes. PI, total budget = 225,119€
PTDC/BIA-CEL/29765/2017
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2018/11 - 2022/04 Twinning Excel in Rare Diseases Research: Focus on Lysosomal Disorders and Ciliopathies (LYSOCIL). Coordinator, total budget = 967,572€
811087
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
European Commission
Concluded
2018/08 - 2021/07 CYP46A1 as a new therapeutic target in Niemann-Pick type C disease. Investigator, total budget = 237,017€
PTDC/MED-NEU/29455/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/06 - 2021/06 A novel mechanism to re-pair Heart Failure with preserved Ejection Fraction (HFpEF) and endothelial damage. Investigator, total budget = 233,434€
PTDC/MED-PAT/32179/2017
Researcher
Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/06 - 2020/05 Regulation of endocytic recycling traffic: implications for ciliogenesis, cell migration and cytokinesis. PI, total budget = 366,913€
IF/00501/2014/CP1252/CT0001
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2018/03 - 2019/09 Developing novel modulators of skin pigmentation. Investigator, total budget = 91,050€
N/A
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
iNOVA4Health
Concluded
2016/04 - 2019/09 Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression. PI, total budget = 198,942€
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/09 - 2018/08 Impairing tumor progression through the inactivation of the small G protein Arl13b. PI, total budget = 12,000€
N/A - NOVAsaúde
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa
Concluded
2015/08 - 2016/03 Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression. PI, total budget = 57,099€
N/A
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
iNOVA4Health
Concluded
2014/04 - 2015/09 Molecular mechanism of melanin transfer in skin pigmentation. Investigator, total budget = 45,840€
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2012/01 - 2015/06 A new approach to fight tuberculosis. co-PI, budget = 197,387€
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2014/04 - 2015/03 Molecular mechanism of melanin transfer in skin pigmentation
EXPL/BEX-BCM/0379/2013
Fundação para a Ciência e a Tecnologia
Concluded
2009/10 - 2014/09 Role of Arl13b in endocytic trafficking. PI, total budget = 100,000€
PIRG05-GA-2009-247726
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
European Commission
Concluded
2011/03 - 2014/08 Molecular mechanisms of melanosome transfer and processing by keratinocytes. PI, total budget = 193,060€
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/04 - 2013/09 Molecular dissection of the intracellular route of Plasmodium in macrophages and dendritic cells. PI, total budget = 199,920€
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/02 - 2013/07 Subversion of the host endocytic pathway by Plasmodium sporozoites. PI, total budget = 199,584€
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2009 - 2010 Role of Arl13b in endocytic trafficking. PI, total budget = 30,000€
N/A
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Camara Municipal Oeiras
Concluded
Outputs

Publications

Book chapter
  1. Cláudio, N.; Pereira, F.J.C.; Barral, D.C.. "Membrane traffic and disease". John Wiley & Sons, Ltd: Chichester, 2014.
    10.1002/9780470015902.a0020892
  2. Sugita, M.; Barral, D.C.; Brenner, M.B.. "Pathways of CD1 and lipid antigen delivery, trafficking, processing, loading, and presentation". 2007.
    10.1007/978-3-540-69511-0-6
Journal article
  1. Andreia Ferreira; Pedro Castanheira; Cristina Escrevente; Duarte C. Barral; Teresa Barona. "Membrane trafficking alterations in breast cancer progression". Frontiers in Cell and Developmental Biology (2024): http://dx.doi.org/10.3389/fcell.2024.1350097.
    10.3389/fcell.2024.1350097
  2. Escrevente, Cristina; Liliana Bento-Lopes; Barral, Duarte C.. "Use of RNA interference to examine the role of Rab11 and its effector Sec15 in lysosome exocytosis". Methods in Molecular Biology (2024):
    Accepted
  3. Matilde V. Neto; Hall, Michael; Charneca, João; Escrevente, Cristina; Miguel C. Seabra; Barral, Duarte C.. "Photoprotective melanin is maintained within keratinocytes in a storage lysosome". Journal of Investigative Dermatology (2024):
    Under revision
  4. Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; et al. "BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2023): 166983. http://dx.doi.org/10.1016/j.bbadis.2023.166983.
    Published • 10.1016/j.bbadis.2023.166983
  5. Liliana Bento-Lopes; Luís C. Cabaço; João Charneca; Matilde V. Neto; Miguel C. Seabra; Duarte C. Barral. "Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241411289.
    10.3390/ijms241411289
  6. Cabaço, Luís C.; Bento-Lopes, Liliana; Neto, Matilde V.; Ferreira, Andreia; Staubli, Wanja B.L.; Ramalho, José S.; Seabra, Miguel C.; Barral, Duarte C.. "RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium". JID Innovations 2 5 (2022): 100139. http://dx.doi.org/10.1016/j.xjidi.2022.100139.
    10.1016/j.xjidi.2022.100139
  7. Nádia Ribeiro; Melissa Albino; Andreia Ferreira; Cristina Escrevente; Duarte Barral; João Pessoa; Catarina Reis; Maria Gaspar; Isabel Correia. "Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23126728.
    10.3390/ijms23126728
  8. Morleo, Manuela; Vieira, Helena L.A.; Pennekamp, Petra; Palma, Alessandro; Bento-Lopes, Liliana; Omran, Heymut; Lopes, Susana S.; Barral, Duarte C.; Franco, Brunella. "Crosstalk between cilia and autophagy: implication for human diseases". Autophagy 19 1 (2022): 24-43. http://dx.doi.org/10.1080/15548627.2022.2067383.
    10.1080/15548627.2022.2067383
  9. Moreiras, Hugo; Bento-Lopes, Liliana; Neto, Matilde V.; Escrevente, Cristina; Cabaço, Luís C.; Hall, Michael J.; Ramalho, José S.; Seabra, Miguel C.; Barral, Duarte C.. "Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization". Traffic 23 6 (2022): 331-345. http://dx.doi.org/10.1111/tra.12843.
    10.1111/tra.12843
  10. Cabaço, Luís C.; Tomás, Ana; Pojo, Marta; Barral, Duarte C.. "The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.887366.
    10.3389/fonc.2022.887366
  11. Duarte C. Barral; Leopoldo Staiano; Cláudia Guimas Almeida; Dan F. Cutler; Emily R. Eden; Clare E. Futter; Antony Galione; et al. "Current methods to analyse lysosome morphology, positioning, motility and function". Traffic (2022): https://doi.org/10.1111/tra.12839.
    10.1111/tra.12839
  12. Michael J. Hall; Sara Lopes-Ventura; Matilde V. Neto; João Charneca; Patricia Zoio; Miguel C. Seabra; Abel Oliva; Duarte C. Barral. "Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer". Pigment Cell & Melanoma Research (2022): https://doi.org/10.1111/pcmr.13039.
    10.1111/pcmr.13039
  13. Brito, C.; Costa-Silva, B.; Barral, D.C.; Pojo, M.. "Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22179260.
    10.3390/ijms22179260
  14. Silva, G.; Sales-Dias J.; Casal, D.; Alves, S.; Domenici, G.; Barreto, C.; Matos, M.R.; et al. "Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer". Cancers (2021): https://www.mdpi.com/2072-6694/13/16/4074.
    10.3390/cancers13164074
  15. Escrevente, C.; Bento-Lopes, L.; Ramalho, J.S.; Barral, D.C.. "Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB". Journal of Cell Science 134 11 (2021): https://doi.org/10.1242/jcs.246694.
    10.1242/jcs.246694
  16. Moreiras, H.; Seabra, M.C.; Barral, D.C.. "Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22094466.
    10.3390/ijms22094466
  17. Brito, C.; Barral, D.C.; Pojo, M.. "Subversion of Ras Small GTPases in Cutaneous Melanoma Aggressiveness.". Frontiers in cell and developmental biology (2020): https://europepmc.org/articles/PMC7538714.
    10.3389/fcell.2020.575223
  18. Casalou, C.; Ferreira, A.; Barral, D.C.. "The Role of ARF Family Proteins and Their Regulators and Effectors in Cancer Progression: A Therapeutic Perspective". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00217.
    10.3389/fcell.2020.00217
  19. Moreiras, H.; Pereira, F.J.C.; Neto, M.V.; Bento-Lopes, L.; Festas, T.C.; Seabra, M.C.; Barral, D.C.. "The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes". Pigment Cell & Melanoma Research 33 2 (2019): 366-371. https://doi.org/10.1111/pcmr.12840.
    10.1111/pcmr.12840
  20. Casalou, C.; Faustino, A.; Silva, F.; Ferreira, I.C.; Vaqueirinho, D.; Ferreira, A.; Castanheira, P.; et al. "Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling". Cancers 11 10 (2019): https://www.mdpi.com/2072-6694/11/10/1461.
    10.3390/cancers11101461
  21. Moreiras, H.; Lopes-da-Silva, M.; Seabra, M.C.; Barral, D.C.. "Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction?". Traffic 20 4 (2019): 301-304. https://doi.org/10.1111/tra.12638.
    10.1111/tra.12638
  22. Kuhns, S.; Seixas, C.; Pestana, S.; Tavares, B.; Nogueira, R.; Jacinto, R.; Ramalho, J.S.; et al. "Rab35 controls cilium length, function and membrane composition". EMBO Reports 20 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070872369&partnerID=MN8TOARS.
    10.15252/embr.201847625
  23. Seixas, E.; Escrevente, C.; Seabra, M.C.; Barral, D.C.. "Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-31171-5.
    10.1038/s41598-018-31171-5
  24. Correia, M.S.; Moreiras, H.; Pereira, F.J.C.; Neto, M.V.; Festas, T.C.; Tarafder, A.K.; Ramalho, J.S.; Seabra, M.C.; Barral, D.C.. "Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments". Journal of Investigative Dermatology 138 3 (2018): 637-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042509194&partnerID=MN8TOARS.
    10.1016/j.jid.2017.09.042
  25. Proença, J.T.; Barral, D.C.; Gordo, I.. "Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli-macrophage interaction". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021725829&partnerID=MN8TOARS.
    10.1038/s41598-017-04081-1
  26. Encarnação, M.; Espada, L.; Escrevente, C.; Mateus, D.; Ramalho, J.; Michelet, X.; Santarino, I.; et al. "A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair". Journal of Cell Biology 213 6 (2016): 631-640. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975456515&partnerID=MN8TOARS.
    10.1083/jcb.201511093
  27. Casalou, C.; Faustino, A.; Barral, D.C.. "Arf proteins in cancer cell migration". Small GTPases 7 4 (2016): 270-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988596463&partnerID=MN8TOARS.
    10.1080/21541248.2016.1228792
  28. Seixas, C.; Choi, S.Y.; Polgar, N.; Umberger, N.L.; East, M.P.; Zuo, X.; Moreiras, H.; et al. "Arl13b and the exocyst interact synergistically in ciliogenesis". Molecular Biology of the Cell 27 2 (2016): 308-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954505839&partnerID=MN8TOARS.
    10.1091/mbc.E15-02-0061
  29. Gonçalves, S.A.; Macedo, D.; Raquel, H.; Simões, P.D.; Giorgini, F.; Ramalho, J.S.; Barral, D.C.; Ferreira Moita, L.; Outeiro, T.F.. "shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity". PLoS Genetics 12 4 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964900124&partnerID=MN8TOARS.
    10.1371/journal.pgen.1005995
  30. Thieleke-Matos, C.; Lopes da Silva, M.; Cabrita-Santos, L.; Portal, M.D.; Rodrigues, I.P.; Zuzarte-Luis, V.; Ramalho, J.S.; et al. "Host cell autophagy contributes to Plasmodium liver development.". Cellular Microbiology 18 3 (2015): 437-450. https://doi.org/10.1111/cmi.12524.
    10.1111/cmi.12524
  31. Chutna, O.; Gonçalves, S.; Villar-Piqué, A.; Guerreiro, P.; Marijanovic, Z.; Mendes, T.; Ramalho, J.; et al. "The small GTPase Rab11 co-localizes with a-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity". Hum Mol Genet 23 25 (2014): 6732-6745. https://doi.org/10.1093/hmg/ddu391.
    10.1093/hmg/ddu391
  32. Tarafder, A.K.; Bolasco, G.; Correia, M.S.; Pereira, F.J.C.; Iannone, L.; Hume, A.N.; Kirkpatrick, N.; et al. "Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis". Journal of Investigative Dermatology 134 4 (2014): 1056-1066. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896629664&partnerID=MN8TOARS.
    10.1038/jid.2013.432
  33. Thieleke-Matos, C.; da Silva, M.L.; Cabrita-Santos, L.; Pires, C.F.; Ramalho, J.S.; Ikonomov, O.; Seixas, E.; et al. "Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection". Traffic 15 10 (2014): 1066-1082. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908503339&partnerID=MN8TOARS.
    10.1111/tra.12190
  34. Casalou, C.; Seixas, C.; Portelinha, A.; Pintado, P.; Barros, M.; Ramalho, J.S.; Lopes, S.S.; Barral, D.C.. "Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration". Journal of Cell Science 127 12 (2014): 2709-2722. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902436592&partnerID=MN8TOARS.
    10.1242/jcs.143446
  35. Seixas, E.; Barros, M.; Seabra, M.C.; Barral, D.C.. "Rab and Arf proteins in genetic diseases". Traffic 14 8 (2013): 871-885. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880131899&partnerID=MN8TOARS.
    10.1111/tra.12072
  36. Barral, D.C.; Garg, S.; Casalou, C.; Watts, G.F.M.; Sandoval, J.L.; Ramalho, J.S.; Hsu, V.W.; Brenner, M.B.. "Arl13b regulates endocytic recycling traffic". Proceedings of the National Academy of Sciences of the United States of America 109 52 (2012): 21354-21359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871834183&partnerID=MN8TOARS.
    10.1073/pnas.1218272110
  37. Lopes da Silva, M.; Thieleke-Matos, C.; Cabrita-Santos, L.; Ramalho, J.S.; Wavre-Shapton, S.T.; Futter, C.E.; Barral, D.C.; Seabra, M.C.. "The host endocytic pathway is essential for plasmodium berghei late liver stage development". Traffic 13 10 (2012): 1351-1363. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866290594&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2012.01398.x
  38. León, L.; Tatituri, R.V.V.; Grenha, R.; Sun, Y.; Barral, D.C.; Minnaard, A.J.; Bhowruth, V.; et al. "Saposins utilize two strategies for lipid transfer and CD1 antigen presentation". Proceedings of the National Academy of Sciences of the United States of America 109 12 (2012): 4357-4364. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863338021&partnerID=MN8TOARS.
    10.1073/pnas.1200764109
  39. Seixas, E.; Ramalho, J.S.; Mota, L.J.; Barral, D.C.; Seabra, M.C.. "Bacteria and protozoa differentially modulate the expression of rab proteins". PLoS ONE 7 7 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864093386&partnerID=MN8TOARS.
    10.1371/journal.pone.0039858
  40. Garg, S.; Sharma, M.; Ung, C.; Tuli, A.; Barral, D.; Hava, D.; Veerapen, N.; et al. "Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b". Immunity 35 2 (2011): 182-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051876839&partnerID=MN8TOARS.
    10.1016/j.immuni.2011.06.009
  41. Odyniec, A.N.; Barral, D.C.; Garg, S.; Tatituri, R.V.; Besra, G.S.; Brenner, M.B.. "Regulation of CD1 antigen-presenting complex stability". Journal of Biological Chemistry 285 16 (2010): 11937-11947. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951210457&partnerID=MN8TOARS.
    10.1074/jbc.M109.077933
  42. Zeissig, S.; Dougan, S.K.; Barral, D.C.; Junker, Y.; Chen, Z.; Kaser, A.; Ho, M.; et al. "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function". Journal of Clinical Investigation 120 8 (2010): 2889-2899. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955294460&partnerID=MN8TOARS.
    10.1172/JCI42703
  43. Van Rhijn, I.; Young, D.C.; De Jong, A.; Vazquez, J.; Cheng, T.-Y.; Talekar, R.; Barral, D.C.; et al. "CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids". The Journal of Experimental Medicine 206 8 (2009): 1831. http://dx.doi.org/10.1084/jem.200824807172009c.
    10.1084/jem.200824807172009c
  44. Barral, D.C.; Cavallari, M.; McCormick, P.J.; Garg, S.; Magee, A.I.; Bonifacino, J.S.; De Libero, G.; Brenner, M.B.. "CD1a and MHC class I follow a similar endocytic recycling pathway". Traffic 9 9 (2008): 1446-1457. http://www.scopus.com/inward/record.url?eid=2-s2.0-49749088918&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2008.00781.x
  45. Barral, D.C.; Brenner, M.B.. "CD1 antigen presentation: How it works". Nature Reviews Immunology 7 12 (2007): 929-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-36448952375&partnerID=MN8TOARS.
    10.1038/nri2191
  46. Miller, M.M.; Wang, C.; Parisini, E.; Coletta, R.D.; Goto, R.M.; Lee, S.Y.; Barral, D.C.; et al. "Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family". Proceedings of the National Academy of Sciences of the United States of America 102 24 (2005): 8674-8679. http://www.scopus.com/inward/record.url?eid=2-s2.0-20844457310&partnerID=MN8TOARS.
    10.1073/pnas.0500105102
  47. Barral, D.C.; Seabra, M.C.. "The Melanosome as a Model to Study Organelle Motility in Mammals". Pigment Cell Research 17 2 (2004): 111-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842421129&partnerID=MN8TOARS.
    10.1111/j.1600-0749.2004.00138.x
  48. Gomes, A.Q.; Ali, B.R.; Ramalho, J.S.; Godfrey, R.F.; Barral, D.C.; Hume, A.N.; Seabra, M.C.. "Membrane targeting of Rab GTPases is influenced by the prenylation motif". Molecular Biology of the Cell 14 5 (2003): 1882-1899. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038247888&partnerID=MN8TOARS.
    10.1091/mbc.E02-10-0639
  49. Anand, V.; Barral, D.C.; Zeng, Y.; Brunsmann, F.; Maguire, A.M.; Seabra, M.C.; Bennett, J.. "Gene therapy for choroideremia: In vitro rescue mediated by recombinant adenovirus". Vision Research 43 8 (2003): 919-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346665670&partnerID=MN8TOARS.
    10.1016/S0042-6989(02)00389-9
  50. Tiwari, S.; Italiano Jr., J.E.; Barral, D.C.; Mules, E.H.; Novak, E.K.; Swank, R.T.; Seabra, M.C.; Shivdasani, R.A.. "A role for Rab27b in NF-E2-dependent pathways of platelet formation". Blood 102 12 (2003): 3970-3979. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345257364&partnerID=MN8TOARS.
    10.1182/blood-2003-03-0977
  51. Hume, A.N.; Collinson, L.M.; Hopkins, C.R.; Strom, M.; Barral, D.C.; Bossi, G.; Griffiths, G.M.; Seabra, M.C.. "The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes". Traffic 3 3 (2002): 193-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036099629&partnerID=MN8TOARS.
    10.1034/j.1600-0854.2002.030305.x
  52. Barral, D.C.; Ramalho, J.S.; Anders, R.; Hume, A.N.; Knapton, H.J.; Tolmachova, T.; Collinson, L.M.; et al. "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". Journal of Clinical Investigation 110 2 (2002): 247-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036073806&partnerID=MN8TOARS.
    10.1172/JCI200215058
  53. Stinchcombe, J.C.; Barral, D.C.; Mules, E.H.; Booth, S.; Hume, A.N.; Machesky, L.M.; Seabra, M.C.; Griffiths, G.M.. "Rab27a is required for regulated secretion in cytotoxic T lymphocytes". Journal of Cell Biology 152 4 (2001): 825-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035911160&partnerID=MN8TOARS.
    10.1083/jcb.152.4.825
  54. Nicole, S.; Davoine, C.-S.; Topaloglu, H.; Cattolico, L.; Barral, D.; Beighton, P.; Hamida, C.B.; et al. "Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)". Nature Genetics 26 4 (2000): 480-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033662239&partnerID=MN8TOARS.
    10.1038/82638
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 Reconstructed skin models in pigmentation and cutaneous melanoma research (invited oral presentation) V SPCAL Congress
(Coimbra, Portugal)
2023 Harnessing Lysosome Dysfunction in Cellular Ageing (invited oral presentation) Longevity Med Summit
(Cascais, Portugal)
2023 Shedding Light on the Mechanisms of Melanin Transfer and Processing (invited oral presentation) 25th International Pigment Cell Conference
International Federation of Pigment Cell Societies (IFPCS) (Bilbao, Spain)
2022 Developing reconstructed human skin models to understand skin pigmentation mechanisms (invited oral presentation) Encontro Ciência
Fundação para a Ciência e a Tecnologia (Lisbon, Portugal)
2022 Molecular Mechanisms of Melanin Transfer and Processing (invited oral presentation) Skin@Bath Network Symposium
(Bath, United Kingdom)
2022 Developing reconstructed human skin models to understand skin pigmentation mechanisms (invited oral presentation) Encontro Ciência’ 2022
(Lisbon, Portugal)
2022 Melanin is stored in lysosomal compartments within keratinocytes (Matilde Neto, selected oral presentation) 1-day 2022 European Society for Pigment Cell Research online meeting
2022 Autophagy regulates melanin organization within keratinocytes (Liliana Bento-Lopes, selected oral presentation) 1-day 2022 European Society for Pigment Cell Research online meeting
2021 Unraveling Griscelli’s syndrome hypopigmentation using a reconstructed pigmented epidermis system (João Charneca, selected oral presentation) 1-day 2021 European Society for Pigment Cell Research online meeting
2021 Autophagy regulates melanin distribution within keratinocytes (Liliana Bento-Lopes, selected oral presentation) 1-day 2021 European Society for Pigment Cell Research online meeting
2021 Rab3a Regulates Melanin Exocytosis Induced by Keratinocyte-Conditioned Medium (Luís Cabaço, selected oral presentation) 1-day 2021 European Society for Pigment Cell Research online meeting
2020 Lysosome Exocytosis Plays a Major Role in Muscle Physiology and Pathology (invited oral presentation) 12 Topics in Rheumatology (2nd Edition)
(Lisbon, Portugal)
2019 Molecular Mechanisms of Skin Pigmentation (invited oral presentation) 10th Meeting on Signal Transduction SINAL
(Olhão, Portugal)
2019 Rab35 Controls Cilium Length, Function and Membrane Composition (selected oral presentation) FASEB Conference on The Biology of Cilia and Flagella
(Snowmass Village, Colorado, United States)
2019 Molecular mechanisms of melanin internalization and processing by keratinocytes (invited oral presentation) LYSOCIL Workshop on Lysosome Biology
(Lisbon, Portugal)
2018 The Exocyst Tethering Complex is Required for Melanin Exocytosis from Melanocytes and Transfer to Keratinocytes (invited oral presentation) 21st Meeting of the European Society for Pigment Cell Research
(Rennes, France)
2018 Molecular Mechanisms of Melanin Transfer Between Melanocytes and Keratinocytes (invited oral presentation) 2nd Small Meeting on Endocytic Trafficking and Signaling
(Braga, Portugal)
2018 Melanocore Internalization by Keratinocytes Occurs Through PAR-2-mediated Phagocytosis (Hugo Moreiras, selected oral presentation) 9th Meeting on Signal Transduction SINAL
(Lisbon, Portugal)
2018 A New Role for Arl13b in Cancer Cell Migration and Invasion Through the Regulation of Cell Adhesion (Alexandra Faustino, selected oral presentation) 9th Meeting on Signal Transduction SINAL
(Lisbon, Portugal)
2018 Rab35 is a Novel Ciliary Protein that Regulates Ciliogenesis and Left-right Asymmetry (Cecília Seixas, selected oral presentation) 9th Meeting on Signal Transduction SINAL
(Lisbon, Portugal)
2018 A Rab11-Rab3 Cascade Involved in the Regulation of Lysosome Exocytosis (Cristina Escrevente, selected oral presentation) 1st Meeting on Vesicular Biology
(Coimbra, Portugal)
2018 A New Role for Arl13b in Cancer Cell Migration and Invasion Through the Regulation of Cell Adhesion (Alexandra Faustino, selected oral presentation) 7th French Cell Adhesion Symposium
(Strasbourg, France)
2017 Melanin Resides in Mildly Acidic and Degradative Compartments and Resists Degradation within Keratinocytes (selected oral presentation) 23rd International Pigment Cell Conference
(Denver, Colorado, United States)
2017 A Rab11-Rab3 Cascade Involved in the Regulation of Lysosome Exocytosis (Cristina Escrevente, selected oral presentation) 8th Meeting on Signal Transduction SINAL
(Lisbon, Portugal)
2016 A New Role for Arl13b in Cancer Cell Migration (invited oral presentation) FASEB Conference on GTPases in Trafficking, Autophagy and Disease
(West Palm Beach, Florida, United States)
2016 Molecular Mechanisms of Melanin Transfer Between Melanocytes and Keratinocytes (invited oral presentation) 1st Small Meeting on Endocytic Trafficking and Signaling
(Braga, Portugal)
2016 A Role for the Endocytic Recycling Pathway in the Exocytosis of Lysosomes (Cristina Escrevente, selected oral presentation) 1st CEDOC Symposium on Chronic Diseases
(Lisbon, Portugal)
2015 Molecular Characterization of Melanin Uptake and Processing by Keratinocytes (selected oral presentation) 19th Meeting of the European Society for Pigment Cell Research
(Edinburgh, United Kingdom)
2014 Unraveling Trafficking for Novel Therapies to Treat Ciliopathies (invited oral presentation) 2nd Symposium on Rare Diseases – Joining All Stakeholders to Discuss Human Genetic Diseases
(Porto, Portugal)
2014 Interaction of Malaria Parasites with Host Late Endocytic and Autophagic Pathways is Essential for Parasite Liver Stage Development (invited oral presentation) Zing Conference on Lysosome Related Organelles
(Nerja, Spain)
2013 Rab11b Mediates Melanin Transfer between Donor Melanocytes and Acceptor Keratinocytes via Coupled Exo/endocytosis (Maria Serrano Correia, selected oral presentation) 18th Meeting of the European Society for Pigment Cell Research
(Lisbon, Portugal)
2013 Arl13b Regulates Circular Dorsal Ruffle Formation and Cell Migration (selected oral presentation) FASEB Conference on Arf and Rab Family G Proteins
(Snowmass Village, Colorado, United States)
2012 Arl13b Regulates Early Endocytic Vesicle Trafficking (selected oral presentation) Cilia in Development and Disease Conference
(London, United Kingdom)
2011 Arl13b Regulates Early Endocytic Vesicle Trafficking (selected oral presentation) EMBO Conference on Dynamic Endosomes: Mechanisms Controlling Endocytosis
(Chania, Greece)
2002 Functional Redundancy of Rab27 proteins: Clues to the Pathogenesis of Griscelli Syndrome (selected oral presentation) XXXVIII Conference in Genetics
(Porto, Portugal)
2001 Platelet Phenotype in Mouse Models of Griscelli and Hermansky-Pudlak Syndromes (selected oral presentation) 4th UK Platelet Meeting
(Cambridge, United Kingdom)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2022 - Current Understanding the role of melanin secretion on cutaneous melanoma invasion and response to immunotherapy (PhD student)
Supervisor of Cristina Demelas
Ciências da Saúde (PhD)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2021 - Current Regulation of lysosome secretion in breast cancer progression (Post-doc)
Supervisor of Cristina Escrevente
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - Current Chromatic equalization of nipple areola-complex reconstruction (PhD student)
Supervisor of Rui Bastos
Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2024/09/30 Molecular mechanisms of melanosome exocytosis (PhD student)
Supervisor of Luís Cabaço
Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2024/09/30 Molecular basis of the cross-talk between skin melanocytes and keratinocytes (PhD student)
Co-supervisor of João Charneca
Mecanismos de Doença e Medicina Regenerativa (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2024/04/29 Cx43 builds the bridge between endocytosis and autophagy: ubiquitin signal dictates the degradation pathway (PhD student)
Co-supervisor of Teresa Rodrigues
Envelhecimento e Doenças Crónicas (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Minho Escola de Medicina, Portugal
2023 - 2023 Role of lysosome exocytosis in breast cancer progression (Master student)
Supervisor of Isabel Sesifredo
Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - 2023 Developing 3D in vitro models of basal cell carcinoma (Master student)
Co-supervisor of Maria Ana Pacheco
Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2023 Testing the role of extracellular vesicles in the early left-right patterning (PhD student)
Co-supervisor of Sara Pestana
Mecanismos de Doença e Medicina Regenerativa (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2023 Modulating membrane traffic regulators to impair breast cancer progression (PhD student)
Supervisor of Andreia Ferreira
Biomedicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2023 Lysosomes dysfunction, the link between Aging and Alzheimer´s disease? (PhD student)
Co-supervisor of Tatiana Burrinha
Biomedicina (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2023 Unveiling a new Cx43-dependent mechanism of plasma membrane repair required for vascular function (PhD student)
Co-supervisor of Daniela Almeida
Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020 - 2022 Nanoformulations of novel metal complexes as potential antitumor agents: in vitro and in vivo studies (Master student)
Co-supervisor of Melissa Albino
Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2022 Biological effect of type I procollagen carboxyterminal propeptide in breast cancer tumor microenvironment (Master student)
Co-supervisor of Miguel Costa
Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2022 Molecular mechanisms of melanin secretion by melanocytes and processing within keratinocytes (PhD student)
Supervisor of Liliana Bento Lopes
Biomedicina (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2021 Modulating membrane traffic regulators to impair breast cancer progression (Master student)
Supervisor of Diana Coito
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2021 Role of TOMM’523 – APOE haplotypes in Alzheimer Disease etiology (PhD student)
Co-supervisor of Rémy Cardoso
Envelhecimento e Doenças Crónicas (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2020 Rab3a as a new regulator of melanin exocytosis (Master student)
Supervisor of Luis Cabaço
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2020 Molecular mechanisms of melanin internalization and processing by keratinocytes (Post-doc)
Supervisor of Mafalda Lopes da Silva
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2020 Role of Arl13b in tumor progression and matastization (PhD student)
Supervisor of Alexandra Faustino
Mecanismos de Doença e Medicina Regenerativa (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2020 Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression (Post-doc)
Supervisor of Cristina Casalou
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2019 Identification of Arl13b GTPase-activating proteins towards the impairment of tumor progression (Master student)
Supervisor of Inês Ferreira
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2019 Investigating the monocyte-to-macrophage differentiation in the gut mucosa: a metabolic perspective (PhD student)
Co-supervisor of Joana Gaifém
Envelhecimento e Doenças Crónicas (associação) (PhD)
Universidade do Minho, Portugal
2016 - 2019 Molecular mechanisms of uptake and processing of melanin by keratinocytes (PhD student)
Supervisor of Hugo Moreiras
Envelhecimento e Doenças Crónicas (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2019 The important role of circular dorsal rufles in the internalization and trafficking of the insulin receptor (PhD student)
Co-supervisor of Margarida Araújo Correia
Mecanismos de Doença e Medicina Regenerativa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2019 Regulation of membrane trafficking pathways involved in the biology of primary cilia (Post-doc)
Supervisor of Cecília Seixas
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2018 Regulation of lysosome secretion (Post-doc)
Supervisor of Cristina Escrevente
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2017 The role of Arl13b and the non-muscle myosin II in cancer cell migration (Master student)
Supervisor of Daniela Vaqueirinho
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2017 Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity (PhD student)
Co-supervisor of Susana Gonçalves
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016 Role of the endocytic recycling pathway in lysosome exocytosis (Master student)
Supervisor of Liliana Bento Lopes
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2016 Primary cilia and the regulation of Hedgehog signaling: link to cardiac development (PhD student)
Supervisor of Ana Portelinha
Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2016 The role of arl13b in cilia length regulation and in zebrafish development (PhD student)
Co-supervisor of Petra Pintado
Ciências da Saúde (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2016 Molecular mechanisms of melanin transfer in skin pigmentation (Post-doc)
Supervisor of Francisco Pereira
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2016 A new approach to fight tuberculosis (Post-doc)
Co-supervisor of Marisa Encarnação
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2015 Molecular mechanism of melanin transfer from donor melanocytes to recipient keratinocytes (Master student)
Supervisor of Tiago Festas
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2015 Role of Arl13b-exocyst interaction in ciliogenesis (Master student)
Supervisor of Hugo Moreiras
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Molecular mechanisms of melanosome transfer and processing by keratinocytes (Post-doc)
Supervisor of Nuno Cláudio
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2014 A new approach to fight tuberculosis (Post-doc)
Supervisor of Lília Espada
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2014 Melanosome transport within and between cells (PhD student)
Supervisor of Maria Serrano Correia
Medicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2008 - 2014 Unraveling the role of host phosphoinositides during Plasmodium liver infection (PhD student)
Supervisor of Carolina Thieleke Matos
Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2013 The role of Arl GTPases in the infection of macrophages by Salmonella (Master student)
Supervisor of João Pedro Santos
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Molecular dissection of the intracellular route of Plasmodium in macrophages and dendritic cells (Post-doc)
Supervisor of Elsa Seixas
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2013 Subversion of the host endocytic pathway by Plasmodium sporozoites (Post-doc)
Supervisor of Laura Cabrita Santos
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2012 Molecular mechanisms of melanosome transfer and processing by keratinocytes (Post-doc)
Supervisor of Abul Tarafder
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/05/30 - 2023/06/02 25th International Pigment Cell Conference (Session chair) (2023) International Federation of Pigment Cell Societies, United States
2021/12/03 - 2021/12/03 1-day 2021 ESPCR online meeting (Session Chair) (2021)
Conference
2020/12/02 - 2020/12/16 Cell Bio Virtual 2020 (Abstract reviewer) (2020)
Congress
American Society for Cell Biology, United States
2019/10/18 - 2019/10/19 10th Meeting on Signal Transduction SINAL (2019)
Conference (Member of the Scientific Committee)
2019/10/05 - 2019/10/05 Workshop - Ciliopathies: rare diseases in discussion (2019)
Workshop (Member of the Organising Committee)
2019/09/09 - 2019/09/11 Workshop on Lysosome Biology (2019)
Workshop (President of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/10/18 - 2018/10/19 2nd NMS Symposium on Chronic Diseases and Translational Science (2018)
Symposium (Member of the Scientific Committee)
2018/09/24 - 2018/09/27 21st Meeting of the European Society for Pigment Cell Research (2018)
Congress (Member of the Scientific Committee)
2018/09/21 - 2018/09/22 9th Meeting on Signal Transduction SINAL (2018)
Conference (Member of the Organising Committee)
2018/02/16 - 2018/02/17 1st Meeting on Vesicular Biology (2018)
Conference (Member of the Scientific Committee)
2017/11/22 - 2017/11/24 Scientific Symposium and Job Fair - Career Opportunities for PostDoctoral Researchers in Life Sciences (2017)
Symposium (Member of the Scientific Committee)
2017/05/01 - 2017/05/02 8th Meeting on Signal Transduction SINAL (2017)
Conference (Member of the Organising Committee)
2016/09/18 - 2016/09/23 FASEB Conference on GTPases in Trafficking, Autophagy and Disease (Session Chair) (2016)
Conference
2016/06/30 - 2016/07/01 1st CEDOC Symposium on Chronic Diseases (2016)
Symposium (Member of the Scientific Committee)
2016/04/28 - 2016/05/02 1st Small Meeting on Endocytic Trafficking and Signaling (2016)
Conference (Member of the Scientific Committee)
2013/09/09 - 2013/09/12 18th Meeting of the European Society for Pigment Cell Research (2013)
Congress (Member of the Organising Committee)

Association member

Society Organization name Role
2022/12 - Current Portuguese Society of Biochemistry Executive Board Member
2021/12 - Current European Society for Pigment Cell Research (ESPCR) Executive Board Member
2010 - Current European Society for Pigment Cell Research (ESPCR) Member
2005 - Current American Society for Cell Biology (ASCB) Member
2003 - Current Portuguese-American Postgraduate Society (PAPS) President (1 year), Vice-President (1 year) and Member

Committee member

Activity description
Role
Institution / Organization
2023/11 - Current Coordinator of the Scientific Committee of Research Infrastructures
Coordinator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/03 - Current Member of the NOVA Medical School Research Committee
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/02 - Current Coordinator of the NOVA Medical School Strategic Area on Cancer
Coordinator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/07 - Current Member of the EIT Health Ageing PhD School Scientific and Business Committee
Member
2022/02 - Current Member of the Scientific Advisory Board of RD Portugal - Union of Rare Diseases Associations
2021/01 - Current Member of the Scientific Advisory Board of the rare disease patient association Sanfilippo Portugal
2017/12 - Current President of the Directive Board of the Inter-University PhD Programme in Aging and Chronic Diseases (PhDOC) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade do Minho Escola de Medicina, Portugal
2015/12 - Current Member of the Scientific Advisory Board of the PhD Programme in Biological Systems, Functional & Integrative Genomics (BioSys) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07 - 2021/12 Coordinator of the core facilities
Coordinator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/03 - 2020/11 Member of the PhD Programmes Committee Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010/09 - 2020/10 Elected member of the Scientific Council Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/04 - 2020/06 Coordinator of the Tissue Culture Unit Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018/07 - 2020/04 Coordinator of Science communication Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/09 - 2020/04 Coordinator of the PhD and Post-doc Committees Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/07 - 2018/11 Elected member of the Directive Board Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/03 - 2018/07 Member of the Evaluation Committee of the new curriculum of the Medical degree Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012/05 - 2018/07 Member of the Selection Committee of the PhD Programme in Medicine and Life Sciences Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/09 - 2017/12 Member of the Scientific Advisory Board of the rare diseases patient association Raríssimas
2013/06 - 2017/11 Member of the Directive Board of the Inter-University PhD Programme in Aging and Chronic Diseases (PhDOC) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade do Minho Escola de Medicina, Portugal
2010/01 - 2013/05 Member of the Directive Board of the Inter-University PhD Programme in Aging and Degeneration of Complex Biological Systems (PhDESC) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade do Minho Escola de Medicina, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2021 - 2024 Final reports of research grants
Evaluator
Fundação para a Ciência e a Tecnologia
2019 - 2024 Research grants
Evaluator
Deutsche Forschungsgemeinschaft
2023 - 2023 Research Grants
Evaluator
Wellcome Trust DBT India Alliance
2022 - 2022 Research grants
Evaluator
Universidade do Algarve Algarve Biomedical Center
2022 - 2022 PhD fellowships - Experimental Biology and Biochemistry panel
Evaluator
Fundação para a Ciência e a Tecnologia
2022 - 2022 Breakthrough Idea Grant (BIG)
Evaluator
Universidade de Lisboa Instituto de Medicina Molecular
2021 - 2022 Exceptional fellowships to mitigate the effects of COVID-19 pandemic
Evaluator
Fundação para a Ciência e a Tecnologia
2010 - 2010 Pfizer Research Prize
Evaluator
Pfizer Portugal
2010 - 2010 Fundação AstraZeneca Innovate Competition
Evaluator
AstraZeneca Produtos Farmacêuticos Lda
2009 - 2009 Research grants
Evaluator
Universidade de Coimbra Faculdade de Medicina
2009 - 2009 Research grants
Evaluator
Suomen Akatemia

Journal scientific committee

Journal title (ISSN) Publisher
2013 - Current Frontiers in Cell and Developmental Biology - Associate Editor (2296-634X) Frontiers Media SA
2017 - 2017 Cellular Logistics - Editorial Board Member (2159-2799) Taylor & Francis
Distinctions

Award

2014 Investigator FCT (Development)
Fundação para a Ciência e a Tecnologia, Portugal
2009 Ciência 2008
Fundação para a Ciência e a Tecnologia, Portugal
2007 Excellence in Tutoring Award
Harvard Medical School, United States
2005 Postdoctoral fellowship
Arthritis Foundation, United States
1999 Ph.D. fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1997 Research fellowship (Bolsa de Investigação Científica)
Fundação para a Ciência e a Tecnologia, Portugal
1996 ERASMUS scholarship
European Union, Belgium
1993 Top ten 1st year student’s Award
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal