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Identification

Personal identification

Full name
Teresa Maria Pereira da Silva

Citation names

  • Silva, Teresa P.

Author identifiers

Ciência ID
891B-8529-4B60
ORCID iD
0000-0002-5039-703X
Google Scholar ID
https://scholar.google.com/citations?user=A-O7kY0AAAAJ&hl=pt-PT

Email addresses

  • teresamsilva@medicina.ulisboa.pt (Professional)
  • teresasilva@tecnico.ulisboa.pt (Professional)
  • teresa_msilva@hotmail.com (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Engineering and Technology - Medical Engineering - Medical Laboratory Technology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/04/08 - 2019/04/09
Concluded
 Workshop on Neuroengineering | 3rd ed - Decoding Neural Information (Outros)
Major in Principles of patch-clamp electrophysiology
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01 - 2018/10
Concluded
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Novel bioengineering strategies for modeling cerebellar ataxias" (THESIS/DISSERTATION)
2015 - 2015
Concluded
 Doctoral Programme in Bioengineering - Cell Therapies and Regenerative Medicine (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Instituto Superior Técnico, Portugal
 18 (in a 20 scale)
2014 - 2014
Concluded
 Course in Laboratory Animal Science accredited by FELASA (category B) (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012 - 2014
Concluded
 Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Multipotent mesenchymal stromal cells for Machado Joseph disease therapy" (THESIS/DISSERTATION)
 18 (in a 20 scale)
2013/03/04 - 2013/03/15
Concluded
 Course in “Translational bigenomics – from the bedside to the bench and back again" (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
 18 (in a 20 scale)
2009 - 2012
Concluded
 Biomedical Pharmacy (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 16 (in a 20 scale)
Affiliation

Science

Category
Host institution 		Employer
2022/10/01 - Current Postdoc (Research) University College London Great Ormond Street Institute of Child Health, United Kingdom
2022/03/01 - 2022/08/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2021/06/01 - 2022/02/28 Contracted Researcher (Research) Instituto de Medicina Molecular, Portugal
2018/12/01 - 2021/05/31 Postdoc (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2014/10 - 2014/12 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2015/01 - 2018/10 PhD student Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
(...)
2013/07 - 2014/09 Master Student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/06/01 - 2013/06/30 Trainee Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Contract

Designation Funders
2022/03 - Current Impact of the Portuguese BRCA2 founder mutation on transcription and tissue stem cell identity
PTDC/MED-ONC/3921/2021
Post-doc
Ongoing
2021/06/01 - 2022/02/28 SpliceHCM – RNA mis-splicing in hypertrophic cardiomyopathy: opportunities for diagnosis and therapy
HR20-00322
Research Fellow
2018/12 - 2021/05 CEREBEX - Generation of gene-edited cerebellar organoids for ataxia research
PTDC/BTM-SAL/29298/2017
Post-doc
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2017/03/01 - Current LysoMod, Genetic and Small Molecule Modifiers of Lysosomal Function
734825
Researcher
European Commission
2017/04 - 2019/06 The DISCOVERIES CENTRE for REGENERATIVE and PRECISION MEDICINE
H2020-WIDESPREAD-01-2016-2017-TeamingPhase2
Researcher
European Commission
Outputs

Publications

Book chapter
  1. Bekman, Evguenia; Silva, Teresa P.; Cotovio, João P.; de Almeida, Rita Mendes. "Reproducing Human Brain Development In Vitro: Generating Cerebellar Neurons for Modelling Cerebellar Ataxias". In Concepts and Applications of Stem Cell Biology, 213-228. Springer International Publishing, 2020.
    10.1007/978-3-030-43939-2_11
  2. Rodrigues, Carlos A.V.; Branco, M.; Nogueira, D.E.S.; Silva, Teresa P.; Gomes, Ana RIta; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Bioreactors for Human Pluripotent Stem Cell Expansion and Differentiation". In Bioreactors for Stem Cell Expansion and Differentiation, 25-45. CRC Press, 2018.
    10.1201/9780429453144-2
Conference abstract
  1. Silva, Teresa P.. "Scalable generation of cerebellar organoids from human pluripotent stem cells". Paper presented in Virtual Workshop on Biochemistry of Ageing - Portuguese Biochemical Society, 2021.
  2. Silva, Teresa P.; Simão Teixeira da Rocha; Inês Milagre; Carolina Pereira; Joaquim M.S. Cabral; Maria Carmo-Fonseca. "iPSC-derived mammary organoids as a model to study the onset of malignant transformation triggered by BRCA mutations". Paper presented in Organoids With]Out[ Borders, Online Symposium, 2020.
  3. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease". Paper presented in XLVIII Reunião Anual da Sociedade de Farmacologia, Lisbon, 2018.
  4. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS". Paper presented in SPDMov 2018 Meeting – “Genética nas Doenças do Movimento”, 2018.
  5. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Covilhã, 2017.
  6. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Nóbrega, Clévio; Barata, João; Sereno, José; Paiva, Vitor; et al. "Sustainable alleviation of motor impairments and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in Machado-Joseph disease". Paper presented in XLVII Reunião Anual da Sociedade de Farmacologia, Coimbra, 2017.
  7. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "3D Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, 2016.
  8. Santana, Magda M.; Paixão, Susana L.; Silva, Teresa P.; Cunha-Santos, J; Cavadas, Claudia; Greif, H.; Pereira de Almeida, Luís. "Trehalose reverses disease phenotype in both in vitro and in vivo models of Machado-Joseph disease transgenic mice". Paper presented in XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIV Reunião anual de Farmacologia Clínica e XV Reunião de Toxicologia, Porto, 2016.
  9. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Nóbrega, Clévio; Sereno, José; Paiva, Vitor; et al. "Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Paper presented in Brain Without Borders Meeting, Coimbra, 2016.
  10. Miranda, Catarina O.; Silva, Teresa P.; Nóbrega, Clévio; Pereira de Almeida, Luís. "Cerebellar transplantation of mesenchymal stromal cells alleviates motor impairments and neuropathology of a transgenic mouse model of Machado-Joseph disease". Paper presented in Term Stem Conference, Porto, 2014.
  11. Silva, Teresa P.; Miranda, Catarina O.; Nóbrega, Clévio; Pereira de Almeida, Luís. "Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado Joseph disease". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, 2014.
Conference paper
  1. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Da Rocha, Simão; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
    10.3389/conf.fncel.2019.01.00041
Conference poster
  1. Silva, Teresa P.; Da Rocha, Simão T.; Milagre, Inês; Pereira, Carolina; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "iPSC-derived mammary progenitors as a model to study the onset of malignant transformation triggered by BRCA mutations". Paper presented in Organoids: Advances and Applications, Virtual Conference from Wellcome Genome Campus – UK, 2021.
  2. Silva, Teresa P.; Simão Teixeira da Rocha; Inês Milagre; Carolina Pereira; Joaquim M.S. Cabral; Maria Carmo-Fonseca. "iPSC-derived mammary organoids as a model to study the onset of malignant transformation triggered by BRCA mutations". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020.
  3. Ana Rita Gomes; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia; Xapeli, Sara; Sebastião, AM; Joaquim M.S. Cabral; Diogo, Maria Margarida. "Modelling Rett syndrome with human patient-specific forebrain organoids". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020.
  4. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Fernandes, Tiago G.; Bekman, Evguenia; Joaquim M.S. Cabral; Simão Teixeira da Rocha. "hiPSC-derived cerebellar organoids to model Angelman syndrome". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020.
  5. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells". Paper presented in EATRIS annual meeting 2020, 2020.
  6. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S.; et al. "Large scale production of cerebellar organoids from human pluripotent stem cells using the novel Vertical-Wheel single-use bioreactors". Paper presented in 7th International Conference on Stem Cell Engineering 2019, 2019.
  7. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "Cerebellar organoids derived from human pluripotent stem cells to model Angelman Syndrome". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
  8. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S.; et al. "Scalable generation of cerebellar neurons from pluripotent stem cells". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, 2019.
  9. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  10. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S.; et al. "Scalable generation of mid-hindbrain organoids from human pluripotent stem cells". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2018.
  11. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Paper presented in 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
  12. Miranda, Catarina O.; Silva, Teresa P.; Marcelo, Adriana; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, 2018.
  13. Rodrigues, Carlos A.V.; Silva, Teresa P.; Fernandes, Tiago G.; Hashimura, Yas; Wesselschmidt, Robin; Diogo, Maria Margarida; Lee, Brian; Cabral, Joaquim M. S.. "Scalable expansion of human induced pluripotent cells on microcarriers using single-used vertical-wheel bioreactors". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  14. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Pereira, Dina; Vasconcelos-Ferreira, Ana; Nóbrega, Clévio; et al. "Repeated treatment with Mesenchymal stromal cells sustainably alleviates Machado-Joseph disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  15. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells". Paper presented in International Society for Stem Cell Research Annual Meeting, 2017.
  16. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Carmo-Fonseca, Maria; Cabral, Joaquim M. S.. "3D Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Paper presented in 5th International Conference on Stem Cell Engineering 2016, 2016.
  17. Santana, Magda M.; Paixão, Susana L.; Silva, Teresa P.; Cunha-Santos, J.; Cavadas, Claudia; Greif, H.; Pereira de Almeida, Luís. "Preclinical studies with Trehalose for Machado-Joseph Disease: in vitro and in vivo models". Paper presented in From NGS to Translational Medicine in Neurological Disease Research, 2016.
  18. Miranda, Catarina O.; Marcelo, Adriana; Silva, Teresa P.; Nóbrega, Clévio; Sereno, José; Castelhano, João; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease". Paper presented in 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2015.
  19. Miranda, Catarina O.; Silva, Teresa P.; Nóbrega, Clévio; Pereira de Almeida, Luís. "Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease". Paper presented in International Society for Stem Cell Research (ISSCR) 2015 annual meeting, 2015.
  20. Santana, Magda M.; Paixão, Susana L.; Trevino, A.; Silva, Teresa P.; Cunha-Santos, J.; Greif, H.; Pereira de Almeida, Luís. "Trehalose alleviates behavioral and neuropathological features in a transgenic mouse model of Machado-Joseph disease". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  21. Silva, Teresa P.; Miranda, Catarina O.; Nóbrega, Clévio; Pereira de Almeida, Luís. "Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado Joseph disease". Paper presented in XII CNC annual meeting, 2014.
Journal article
  1. Gaudioso, Ángel; Silva, Teresa P.; Dolores Ledesma, María. "Models to study basic and applied aspects of lysosomal storage disorders". Advanced Drug Delivery Reviews 190 (2022): 114532. http://dx.doi.org/10.1016/j.addr.2022.114532.
    10.1016/j.addr.2022.114532
  2. Miranda, Cláudia C.; Akenhead, Michael L.; Silva, Teresa P.; Derr, Michael A.; Vemuri, Mohan C.; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "A Dynamic 3D Aggregate-Based System for the Successful Expansion and Neural Induction of Human Pluripotent Stem Cells". Frontiers in Cellular Neuroscience 16 (2022): http://dx.doi.org/10.3389/fncel.2022.838217.
    10.3389/fncel.2022.838217
  3. Lee, Brian; Jung, Sunghoon; Hashimura, Yas; Lee, Maximilian; Borys, Breanna S.; Dang, Tiffany; Kallos, Michael S.; et al. "Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products". Bioengineering 9 3 (2022): 92. http://dx.doi.org/10.3390/bioengineering9030092.
    10.3390/bioengineering9030092
  4. Silva, Teresa P.; Sousa-Luís, Rui; Fernandes, Tiago G.; Bekman, Evguenia P.; Rodrigues, Carlos A. V.; Vaz, Sandra H.; Moreira, Leonilde M.; et al. "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions". Biotechnology and Bioengineering (2021): http://dx.doi.org/10.1002/bit.27797.
    10.1002/bit.27797
  5. Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364.
    10.1016/j.scr.2021.102364
  6. Silva, Teresa P. (891B-8529-4B60); Pereira, Carolina A.; Rita Oliveira, Ana; Cláudia Raposo, Ana; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Teixeira da Rocha, Simão. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242.
    10.1016/j.scr.2021.102242
  7. Gomes, Ana Rita; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia P.; Xapelli, Sara; Duarte, Sofia; et al. "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.610427.
    10.3389/fcell.2020.610427
  8. Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luís; Miranda, Catarina O.. "Mesenchymal Stromal Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.584277.
    10.3389/fncel.2020.584277
  9. Silva, Teresa P.; Fernandes, Tiago G.; Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Bekman, Evguenia P.; Hashimura, Yas; Jung, Sunghoon; et al. "Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining". Journal of Visualized Experiments 160 (2020): http://dx.doi.org/10.3791/61143.
    10.3791/61143
  10. Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa P.; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2.
    10.1186/s12967-020-02302-2
  11. Lee, Brian; Borys, Breanna S.; Kallos, Michael S.; Rodrigues, Carlos A. V.; Silva, Teresa P.; Cabral, Joaquim M. S.. "Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products". Bioengineering 7 2 (2020): 31. http://dx.doi.org/10.3390/bioengineering7020031.
    10.3390/bioengineering7020031
  12. Silva, João C.; Han, Xiaorui; Silva, Teresa P.; Xia, Ke; Mikael, Paiyz E.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Linhardt, Robert J.. "Glycosaminoglycan remodeling during chondrogenic differentiation of human bone marrow-/synovial-derived mesenchymal stem/stromal cells under normoxia and hypoxia". Glycoconjugate Journal (2020): http://dx.doi.org/10.1007/s10719-020-09911-5.
    10.1007/s10719-020-09911-5
  13. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Vaz, Sandra H.; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00070.
    10.3389/fbioe.2020.00070
  14. Silva, Teresa P.; Cotovio, João P.; Bekman, Evguenia; Carmo-Fonseca, Maria; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering". Stem Cells International 2019 (2019): 1-17. http://dx.doi.org/10.1155/2019/4508470.
    10.1155/2019/4508470
  15. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    10.1016/j.ymthe.2018.07.007
  16. Rodrigues, Carlos A.V.; Silva, Teresa P.; Nogueira, Diogo ES; Fernandes, Tiago G.; Hashimura, Yas; Wesselschmidt, Robin; Diogo, Maria Margarida; Lee, Brian; Cabral, Joaquim MS. "Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheel™ bioreactors". Journal of Chemical Technology & Biotechnology 93 12 (2018): 3597-3606. http://dx.doi.org/10.1002/jctb.5738.
    10.1002/jctb.5738
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/03/24 Organoids as a model for brain studies Modelos para o Estudo do Cérebro e Implicações Bioéticas, Brain Gain - À descoberta das Neurociências,
(Portugal)
2020/07/02 Scalable Generation of Cerebellar Organoids for Disease Modeling Lisbon area Stem Cell Club
2020/06/08 Organoids as Models for Cerebellar Development Brain Organoids Virtual Seminar, StemCell Technologies
2019/12/13 Cancer development in mammary organoids from BRCA mutation carriers DevBioMed Symposium
Champalimaud Center for the Unknown (Lisbon, Portugal)
2019/11 Novel bioengineering strategies for modeling cerebellar ataxias Lisbon Area Postdoc Meeting 2019
(Costa da Caparica, Portugal)
2019 Organoids as model for studying cerebellar dysfunctions iBB seminar
(Lisbon, Portugal)
2016/03 Trehalose reverses the phenotype of Machado-Joseph disease models 10th World Congress on Controversies in Neurology (CONy)
(Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - Current Study the functional impact of the BRCA2 Portuguese Founder Mutation in mammary epithelial progenitors
Co-supervisor
 Medicine (Master)
Faculdade de Medicina, Universidade de Lisboa, Portugal
2021/02 - 2021/10 iPSC-derived mammary organoids to study the onset of malignant transformation triggered by BRCA mutations.
Supervisor
Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021 Cell-based clinical therapies for spinal cord injury treatment
(Thesis) Main arguer
 Bruna Daniela Coelho Cruz (Master)
Universidade de Aveiro, Portugal

Association member

Society Organization name Role
2017 - Current Sociedade Portuguesa de Células Estaminais e Terapia Celular Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/01 - 2022/01 Terapia Celular e Medicina Regenerativa - “Organoids as model for brain studies” Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal
2021/12 - 2021/12 Systems Bioengineering- "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids" Engenharia Biológica (Mestrado integrado) Instituto Superior Técnico, Portugal
2021/05 - 2021/05 Biologia e Tecnologia de Células Estaminais - "Modeling neural development in vitro using brain organoids" Biologia Evolutiva e do Desenvolvimento (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/04 - 2021/04 Systems Bioengineering - "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids" Ciências de Engenharia - Engenharia Biológica (Licenciatura) Instituto Superior Técnico, Portugal
2020/12 - 2020/12 Terapia Celular e Medicina Regenerativa Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal
2020/10 - 2020/10 Stem cell bioengineering Engenharia Biológica (Mestrado integrado) Instituto Superior Técnico, Portugal
2020/05 - 2020/05 Biologia e Tecnologia de Células Estaminais (Stem Cell Biology and Technology) Biologia Evolutiva e do Desenvolvimento (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/05 - 2020/05 Organoids as model for studying cerebellar dysfunctions Ciências de Engenharia Biomédica (Licenciatura) Universidade de Aveiro, Portugal
2019/11 - 2019/11 Terapia Celular e Medicina Regenerativa (Cell Therapy and Regenerative Medicine) Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal
2019/10 - 2019/10 Stem Cell Bioengineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/10 - 2019/10 Stem Cell Bioengineering Biotecnologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/05 - 2018/05 Systems Bioengineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/05 - 2018/05 Biologia e Tecnologia de Células Estaminais (Stem Cell Biology and Technology) Biologia Evolutiva e do Desenvolvimento (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2017/05 - 2017/05 Biologia e Tecnologia de Células Estaminais (Stem Cell Biology and Technology) Biologia Evolutiva e do Desenvolvimento (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current Frontiers in Neuroscience Frontiers
2021 - Current Bioengineering (2306-5354) MDPI
2021 - Current International Journal of Molecular Sciences MDPI

Mentoring / Tutoring

Topic Student name
2018 - 2021 Scalable production of mature neuronal subtypes from cerebellar organoids in dynamic 3D conditions to model human disease Carina Maranga
2018 - 2019 Mammary organoids to study the functional impact of BRCA mutations Catarina Guerra Ferreira
2017 - 2018 Generating isogenic NPC1 hiPSC lines for disease modeling using the CRISPR/Cas9 system Joaquim Filipe Godinho
Distinctions

Other distinction

2017 Registration Grant - 10th International Meeting of the SPCE-TC
2016 EMBO Travel Grant - EMBO/EMBL Symposium Organoids: Modelling Organ Development and Disease in 3D Culture