ADRIANA OLIVEIRA DOS SANTOS (891C-417A-1534)

Curriculum Vitae

ADRIANA OLIVEIRA DOS SANTOS

Adriana O. Santos holds a degree in Pharmaceutical Sciences (2003) and a Ph.D. in Pharmacy (2009), specializing in Pharmaceutical Technology, from the University of Coimbra. Her doctoral thesis focused on targeted liposomes of siRNA for the treatment of small cell lung cancer. Adriana was a postdoctoral researcher at Institut Curie in Paris (2009-2012), where she studied the intracellular signaling of Ral and RalGEFs in lung cancer cells. Since 2012, Adriana has been an Assistant Professor at the University of Beira Interior in the Department of Medical Sciences and a researcher at CICS-UBI. Since 2015, she participated in the scientific and pedagogical coordination committees of the Pharmaceutical Sciences Integrated Masters degree and was recently appointed as the mobility coordinator for the same course. She also coordinates the research group "Drug Discovery, Development, and Safety" (3DS) at CICS-UBI and is a member of its executive committee. Adriana supervised a Ph.D. thesis in Pharmaceutical Sciences (March 2021), co-supervised 42 master's dissertations, and supervised 6 undergraduate projects. Her recent research has focused on intranasal drug delivery for action in the brain. She is a (co)author of 40 full articles in peer-reviewed scientific journals, with 25 published in the last 5 years (2019-2023). She has also authored 2 book chapters and contributed to over 57 communications in scientific meetings. She is listed as an inventor on a pending international patent. Adriana was the principal investigator of a project awarded the "CICS-UBI Collaborative Project Awards" in 2021 titled "Intranasal Delivery of Simvastatin in Stroke" and a proof-of-concept research project (PO Centro) titled " Segesterone Acetate Innovative Nanoemulsion" (SAIN). She has participated in 5 doctoral examination boards, 3 times as an examiner and 2 as a committee member, and in scientific committees of international meetings.

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Identification

Personal identification

Full name: ADRIANA OLIVEIRA DOS SANTOS
Date of birth: 1979/07/16
Gender: Female

Citation names

SANTOS, ADRIANA O.
Santos, A.O.; Santos A; O. Santos, A.

Author identifiers

Ciência ID: 891C-417A-1534
ORCID iD: 0000-0002-1224-9191
Researcher Id: H-4597-2011
Scopus Author Id: 14049212000

Email addresses

asantos@fcsaude.ubi.pt (Professional)
aos@ubi.pt (Professional)

Telephones

Telephone

275329079 (Professional)

Addresses

Faculdade de Ciências da Saúde, Av. Infante D. Henrique, 6200-506 , Covilhã, Covilhã, Portugal (Professional)

Websites

https://www.ubi.pt/Pessoa/aos | http://orcid.org/0000-0002-1224-9191 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)

Education

	Degree	Classification
2009/10/29 Concluded	Pharmacy (Doutoramento) Major in Pharmaceutics Universidade de Coimbra Faculdade de Farmácia, Portugal "Targeted Gene Silencing Therapy in Small Cell Lung Cancer" (THESIS/DISSERTATION)	Distinção e Louvor (Approved with praise and disti
1997/10 - 2003/07/23 Concluded	Pharmaceutical Sciences (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal "n/a" (THESIS/DISSERTATION)	16 valores (16 values, out of 20)

Affiliation

Science

	Category Host institution	Employer
2009/11/01 - 2012/10/31	Postdoc (Research)	Institut Curie, France
	Institut Curie, France
2009/08/17 - 2009/10/31	Visiting Researcher (Research)	Institut Curie, France

2003/10/01 - 2007/09/30	Researcher (Research)	Fundação para a Ciência e a Tecnologia, Portugal

2005/02/01 - 2005/12/21	Visiting Researcher (Research)	UniversitätsSpital Zürich, Switzerland

2002/10/01 - 2002/12/20	Research Trainee (Research)	Universidad de Salamanca, Spain

Teaching in Higher Education

	Category Host institution	Employer
2012/11/02 - Current	Assistant Professor (University Teacher)	Universidade da Beira Interior, Portugal

Positions / Appointments

	Category Host institution	Employer
2022/07 - Current	Coordinator of the research group 3DS of CICS-UBI and inherently member of the executive committee of the same research unit.	Universidade da Beira Interior, Portugal
	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/01/01 - Current	Integrated Member	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/10 - 2021/10	Vice-coordinator of the research group BCDR of CICS-UBI and inherently member of the executive committee of the same research unit.	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Projects

Grant

	Designation	Funders
2022/06/01 - 2023/05/31	Segesterone Acetate Innovative Nanoemulsion (SAIN) CENTRO-01-0145-FEDER-181231 Principal investigator Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	European Union Comissão de Coordenação e Desenvolvimento Regional do Centro Ongoing
2020/10/05 - 2021/07/06	CovidOUT - Spray to reduce the nasal transmission of coronavirus CENTRO-01-02B7-FEDER-069358 Researcher Health Products Research and Development Lda. , Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	European Development Fund Comissão de Coordenação e Desenvolvimento Regional do Centro Concluded
2017/04 - 2020/03	ICON - Interdisciplinary Challenges On Neurodegeneration CENTRO-01-0145-FEDER-000013 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	European Commission Concluded
2016 - 2019	Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery PTDC/QEQ-MED/7042/2014 Researcher Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2012	Deciphering the networks leading to the activation of the Ral GTPases in human lung cancers, dependently or not on Ras RS12/75-62	Ligue Nationale Contre Le Cancer
2009/11 - 2011/10	The RAL-pathway as a key pathway and target in oncogenisis - From the RalGEFs, to the exocyst complex, to the executioners Engt 2008005019	Fondation de France
2003/10/01 - 2007/09/30	PROGRAMA DOUTORAL EM BIOLOGIA EXPERIMENTAL E BIOMEDICINA SFRH/BD/11817/2003	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2023/03/01 - 2024/02/29	Multifunctional Innovative NanoDevice for lung cancer therapy (MIND) MIND Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Banco Santander Portugal Ongoing
2023/02/01 - 2023/06/30	Nanoemulsão Inovadora para Tratamento Antimicrobiano (NITA) NITA Researcher Universidade da Beira Interior, Portugal	European Regional Development Fund Concluded
2021/11/01 - 2022/10/31	Intranasal Delivery of Simvastatin in Stroke UIDP/Multi/00709/2020 Principal investigator Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde Ongoing

Outputs

Publications

Book chapter

Melo, Dora; Patrícia C. Pires; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Intranasal administration of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems. Elsevier, 2020.
Published
SANTOS, ADRIANA; Moreira, J.N.; Bimbo, L.M.; Gomes da Silva, L; Pedrososo de Lima, M. C.; Simões, S.. "Gene silencing therapy in small cell lung cancer – which agents, targets, and delivery systems?". In In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, edited by Jonathon G. Maldonado; Mikayla K. Cervantes, 1-50. Nova Science, 2009.
Published

Journal article

Guedes, Romina A.; Grilo, Jorge H.; Carvalho, Andreia N.; Fernandes, Pedro M. P.; Ressurreição, Ana S.; Brito, Vanessa; SANTOS, ADRIANA O.; et al. Corresponding author: Guedes, Rita C.. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals 16 8 (2023): 1096. http://dx.doi.org/10.3390/ph16081096.
Open access • Published • 10.3390/ph16081096
Pires, Patrícia C.; Fernandes, Mariana; Nina, Francisca; Gama, Francisco; Gomes, Maria F.; Rodrigues, Lina E.; Meirinho, Sara; et al. Corresponding author: SANTOS, ADRIANA O.. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics 15 7 (2023): 1878. http://dx.doi.org/10.3390/pharmaceutics15071878.
Open access • Published • 10.3390/pharmaceutics15071878
Lima, Eurico; Barroso, Andreia G.; Ferreira, Octávio; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; SANTOS, ADRIANA O.; Reis, Lucinda V.. Corresponding author: SANTOS, ADRIANA O.. "Benz[e]indole-bearing aminosquaraine dyes: Which of the amines introduced into the squaric ring will be able to induce the best in vitro photodynamic effect?". Dyes and Pigments 215 (2023): 111239. http://dx.doi.org/10.1016/j.dyepig.2023.111239.
Published • 10.1016/j.dyepig.2023.111239
Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Nose-to-brain delivery of perampanel formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice". International Journal of Pharmaceutics 642 (2023): 123145. http://dx.doi.org/10.1016/j.ijpharm.2023.123145.
10.1016/j.ijpharm.2023.123145
Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting". Pharmaceutics 15 6 (2023): 1641. http://dx.doi.org/10.3390/pharmaceutics15061641.
Open access • Published • 10.3390/pharmaceutics15061641
Matias, Mariana; SANTOS, ADRIANA O.; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Fighting Epilepsy with Nanomedicines - Is This the Right Weapon?". Pharmaceutics 15 2 (2023): 306. http://dx.doi.org/10.3390/pharmaceutics15020306.
Published • 10.3390/pharmaceutics15020306
Vanessa Brito; SANTOS, ADRIANA O.; Gilberto Alves; Paulo Almeida; Samuel Silvestre. Corresponding author: Samuel Silvestre. "Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies". Molecules 27 18 (2022): 6126-6126. http://dx.doi.org/10.3390/molecules27186126.
Published • 10.3390/molecules27186126
João L. Serrano; Ana Maia; Adriana O. Santos; Eurico Lima; Lucinda V. Reis; Maria J. Nunes; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. Corresponding author: Paulo Almeida. "An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells". Molecules 27 18 (2022): 5779-5779. https://doi.org/10.3390/molecules27185779.
10.3390/molecules27185779
Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration". Pharmaceutics 14 7 (2022): 1487. http://dx.doi.org/10.3390/pharmaceutics14071487.
Open access • 10.3390/pharmaceutics14071487
Gomes, Diana; Yaduvanshi, Shivani; Silvestre, Samuel; Duarte, Ana Paula; SANTOS, ADRIANA O.; Soares, Christiane P.; Kumar, Veerendra; Passarinha, Luís; Sousa, Ângela. Corresponding author: Sousa, Ângela. "Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells". Cancers 14 12 (2022): 2834. http://dx.doi.org/10.3390/cancers14122834.
Published • 10.3390/cancers14122834
Meirinho, Sara; Rodrigues, Márcio; Ferreira, Catarina L.; Oliveira, Rui Caetano; Fortuna, Ana; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel". International Journal of Pharmaceutics 622 (2022): 121853. http://dx.doi.org/10.1016/j.ijpharm.2022.121853.
10.1016/j.ijpharm.2022.121853
Catarina Canário; Mariana Matias; Vanessa Brito; Patrícia Pires; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. Corresponding author: Gilberto Alves. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579-3579. https://doi.org/10.3390/app12073579.
10.3390/app12073579
Pires, Patrícia C.; Rodrigues, Márcio; Alves, Gilberto; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics 14 3 (2022): 588. http://dx.doi.org/10.3390/pharmaceutics14030588.
Open access • Published • 10.3390/pharmaceutics14030588
Canário, Catarina; Matias, Mariana; Brito, Vanessa de; Cruz-Vicente, Pedro; Soeiro, Pedro; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "10ß-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro biological evaluation and in silico studies". Natural Product Research 36 24 (2022): 6459-6463. http://dx.doi.org/10.1080/14786419.2022.2039136.
10.1080/14786419.2022.2039136
Lima, Eurico; Barroso, Andreia G.; Sousa, Margarida A.; Ferreira, Octávio; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; et al. Corresponding author: SANTOS, ADRIANA O.. "Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents". European Journal of Medicinal Chemistry 229 (2022): 114071. http://dx.doi.org/10.1016/j.ejmech.2021.114071.
Published • 10.1016/j.ejmech.2021.114071
Pires, Patrícia C.; Fazendeiro, Ana C.; Rodrigues, Márcio; Alves, Gilberto; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European Journal of Pharmaceutical Sciences 164 (2021): 105918. http://dx.doi.org/10.1016/j.ejps.2021.105918.
Open access • Published • 10.1016/j.ejps.2021.105918
Canário, Catarina; Matias, Mariana; Brito, Vanessa; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies". Molecules 26 9 (2021): 2687. http://dx.doi.org/10.3390/molecules26092687.
Published • 10.3390/molecules26092687
Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; et al. "Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes". Journal of Inorganic Biochemistry 216 (2021): 111331. http://dx.doi.org/10.1016/j.jinorgbio.2020.111331.
Published • 10.1016/j.jinorgbio.2020.111331
Canário, Catarina; Matias, Mariana; de Brito, Vanessa; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Delta 9,11-Estrone derivatives as potential antiproliferative agents: synthesis, in vitro biological evaluation and docking studies". Comptes Rendus. Chimie 23 2 (2020): 201-217. http://dx.doi.org/10.5802/crchim.17.
Published • 10.5802/crchim.17
Lima, Eurico; Ferreira, Octávio; Silva, Joana F.; SANTOS, ADRIANA O.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Reis, Lucinda V.. Corresponding author: Reis, Lucinda V.. "Photodynamic activity of indolenine-based aminosquaraine cyanine dyes: Synthesis and in vitro photobiological evaluation". Dyes and Pigments 174 (2020): 108024. http://dx.doi.org/10.1016/j.dyepig.2019.108024.
Published • 10.1016/j.dyepig.2019.108024
Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization". European Journal of Pharmaceutical Sciences 141 (2020): 105099. http://dx.doi.org/10.1016/j.ejps.2019.105099.
Open access • Published • 10.1016/j.ejps.2019.105099
Lima, Eurico; Ferreira, Octávio; Gomes, Vanessa S.D.; Santos, Adriana O.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Reis, Lucinda V.. "Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine". Dyes and Pigments 167 (2019): 98-108. http://dx.doi.org/10.1016/j.dyepig.2019.04.007.
10.1016/j.dyepig.2019.04.007
Ana Carolina Almeida Gonçalves; Márcio Rodrigues; Santos, A. O.; Gilberto Alves; Luís R. Silva. "Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits". Nutrients (2018): http://www.mdpi.com/2072-6643/10/11/1688.
10.3390/nu10111688
Vanessa Brito; Adriana O. Santos; Paulo Almeida; Samuel Silvestre. "Novel 4-azaandrostenes as prostate cancer cell growth inhibitors: Synthesis, antiproliferative effects, and molecular docking studies". Comptes Rendus Chimie (2018): https://doi.org/10.1016%2Fj.crci.2018.07.011.
10.1016/j.crci.2018.07.011
Pires, Patrícia C.; Santos, Adriana O.. "Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies". Journal of Controlled Release 270 (2018): 89-100. http://dx.doi.org/10.1016/j.jconrel.2017.11.047.
Published • 10.1016/j.jconrel.2017.11.047
Ferreira, A.; Santos, A.O.; Falcão, A.; Alves, G.. "In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs". Food and Chemical Toxicology 111 (2018): 84-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033366631&partnerID=MN8TOARS.
10.1016/j.fct.2017.11.004
Catarro, M.; Serrano, J.; Cavalheiro, E.; Ramos, S.; Santos, A.O.; Silvestre, S.; Almeida, P.. "Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies". Bioorganic and Medicinal Chemistry 25 16 (2017): 4304-4313. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021808666&partnerID=MN8TOARS.
10.1016/j.bmc.2017.06.009
O Santos, A.; Parrini, M.C.; Camonis, J.. "RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases". PloS one 11 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85011808140&partnerID=MN8TOARS.
10.1371/journal.pone.0154840
Matias, M.; Campos, G.; Santos, A.O.; Falcão, A.; Silvestre, S.; Alves, G.. "Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones". Arabian Journal of Chemistry (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008352523&partnerID=MN8TOARS.
10.1016/j.arabjc.2016.12.007
Matias, M.; Campos, G.; Santos, A.O.; Falcão, A.; Silvestre, S.; Alves, G.. "Potential antitumoral 3,4-dihydropyrimidin-2-(1: H)-ones: synthesis, in vitro biological evaluation and QSAR studies". RSC Advances 6 88 (2016): 84943-84958. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987657546&partnerID=MN8TOARS.
10.1039/c6ra14596e
Antunes Viegas, D.; Rodrigues, M.; Francisco, J.; Falcão, A.; Alves, G.; Santos, A.O.. "Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method". European Journal of Pharmaceutical Sciences 89 (2016): 61-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964613921&partnerID=MN8TOARS.
10.1016/j.ejps.2016.04.018
Santos, D.; Medeiros-Silva, J.; Cegonho, S.; Alves, E.; Ramilo-Gomes, F.; Santos, A.O.; Silvestre, S.; Cruz, C.. "Cell proliferation effects of calix[4]arene derivatives". Tetrahedron 71 40 (2015): 7593-7599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940462179&partnerID=MN8TOARS.
10.1016/j.tet.2015.07.077
Levallet, G.; Bergot, E.; Antoine, M.; Creveuil, C.; Santos, A.O.; Beau-Faller, M.; De Fraipont, F.; et al. "High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-ras signaling pathway". Molecular Cancer Therapeutics 11 5 (2012): 1203-1213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862742698&partnerID=MN8TOARS.
10.1158/1535-7163.MCT-11-0899
Gomes-Da-Silva, L.C.; Santos, A.O.; Bimbo, L.M.; Moura, V.; Ramalho, J.S.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N.. "Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment". International Journal of Pharmaceutics 434 1-2 (2012): 9-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864129727&partnerID=MN8TOARS.
10.1016/j.ijpharm.2012.05.018
Santos, A.O.; da Silva, L.C.G.; Bimbo, L.M.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Design of peptide-targeted liposomes containing nucleic acids". Biochimica et Biophysica Acta - Biomembranes 1798 3 (2010): 433-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749124054&partnerID=MN8TOARS.
10.1016/j.bbamem.2009.12.001
Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N.. "In vitro modulation of Bcl-2 levels in small cell lung cancer cells: Effects on cell viability". Brazilian Journal of Medical and Biological Research 43 10 (2010): 1001-1009. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149263712&partnerID=MN8TOARS.
10.1590/S0100-879X2010007500099
Santos, A.; Pereira, J. P.; Pedroso de Lima, M. C.; Simoes, S.; Moreira, J. N.. "SiRNA mediated clownregulation of Bcl-2 in small cell lung cancer cell lines - impact on protein level and cell viability". Ejc Supplements 6 9 (2008): 74-74.
10.1016/S1359-6349(08)71460-5
Moreira, J.N.; Santos, A.; Moura, V.; De Uma, M.C.P.; Simões, S.. "Non-viral lipid-based nanoparticles for targeted cancer systemic gene silencing". Journal of Nanoscience and Nanotechnology 8 5 (2008): 2187-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS.
10.1166/jnn.2008.319
Santos, A.; Sarmento-Ribeiro, A.B.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N.. "Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer". Cytometry Part A 73 12 (2008): 1165-1172. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749165193&partnerID=MN8TOARS.
10.1002/cyto.a.20634
Moreira, J.N.; Santos, A.; Simões, S.. "Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality.". Reviews on recent clinical trials 1 3 (2006): 217-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-44849085132&partnerID=MN8TOARS.
10.2174/157488706778250050

Intellectual property

Patent

SANTOS, ADRIANA O.; Fernandes, Mariana Carvalho; Pires, Patrícia Sofia Cabral; Gilberto Lourenço Alves (BA10-57D6-DF00); Fazendeiro, Ana Carolina Maricoto; Nina, Francisca Matos Silva Pereira; Maria de Fátima da SilvaFerreira Gomes; Rodrigues, Lina Isabel Esteves. 2022. "SELF-EMULSIFYING COMPOSITION, PRODUCTION METHODS AND USES THEREOF".
Pending

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2020	Nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin - formulation development, in vitro characterization and in vivo pharmacokinetics	FENS 2020 Virtual Forum FENS
2020	Brain delivery of poorly soluble drugs: a proof-of-concept of phosphate esters as a way of increasing solubility and bioavailability	Controlled Release Society Virtual Annual Meeting Controlled Release Society
2019/11/14	Intranasal administration of fosphenytoin: assay development and validation and preliminary in vivo pharmacokinetic studies.	III International Congress in Health Sciences Research.T owards Innovation and Entrepreneurship: Trends in Aging and Cancer. CICS-UBI (Covilhã, Portugal)
2019/11	Sweet cherries phenolic-rich fractions exhibit anti-cancer properties and can modulate P-glycoprotein activity	III International Congress in Health Sciences Research. Towards Innovation and Entrepreneurship: Trends in Aging and Cancer CICS-UBI (Covilhã, Portugal)
2019/11	Proteosome inhibition of synthetic 5-5ubstituted (thio)barbiturates	III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer CICS-UBI (Covilhã, Portugal)
2019/03/25	Oral self-emulsifying drug delivery system and intranasal nanoemulsions of phenytoin.	3rd European Conference on Pharmaceutics (Bolonha, Italy)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/10/01 - Current	Targeting Photodynamic Cancer Therapy with Squarine Cyanine Dyes (1st october 2019 -present) Co-supervisor of Eurico Emanuel Avelar de Serpa Vieira Lima	Universidade de Trás-os-Montes e Alto Douro, Portugal
2021 - 2022/03	Desenvolvimento de um ensaio para a avaliação ex vivo da toxicidade local de preparações nasais Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2021 - 2022/02	Desenvolvimento e otimização de nanoemulsões catiónicas Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2021 - 2022/01	Desenvolvimento de Micro e Nanoemulsões O/A para administração intranasal de Nestorona em Acidente Vascular Cerebral Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2017 - 2021/03/22	The promise of prodrugs and nanosystems in nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin. Supervisor of Patrícia Sofia Cabral Pires	Ciências Farmacêuticas (PhD) Universidade da Beira Interior, Portugal
2017 - 2021/03	Estudo das condições de entrega intranasal de oligonucleótidos ao cérebro. Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2019 - 2021/01	Revisão de modelos de epitélio nasal humano nos estudos pré-clínicos de segurança. Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2020 - 2021	Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula. Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2020 - 2021	Desenvolvimento de microemulsões de fenitoína e fosfenitoína Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2021	Estudo das condições de entrega intranasal de oligonucleótidos ao cérebro Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019/11	Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019/10	Desenvolvimento de veículos palatáveis com boa aceitabilidade oral para a preparação de soluções autoemulsionantes para a via oral. Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019/10	Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis. Supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Synthesis and evaluation of 5-substituted (thio)barbiturates as proteasome inhibitors for cancer therapy. Co-supervisor of Sara Hummeid	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Segurança e eficácia das microagulhas - revisão de ensaios clínicos. Supervisor of José pedro Antunes Peres	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Desenvolvimento de uma emulsão O/A de sinvastatina para administração intranasal. Supervisor of Mariana Carvalho Fernandes	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Desenvolvimento de uma formulação para administração de sRNA. Co-supervisor	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Desenvolvimento de veículos palatáveis com boa aceitabilidade oral para a preparação de soluções autoemulsionantes para a via oral. Supervisor of Beatriz Alexandra Correia Patrício	Ciências Básicas Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis. Supervisor of Liliana Teixeira dos Santos	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2018 - 2019	Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia. Supervisor of Dora Fátima Neves de Melo	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2017 - 2018	Desenvolvimento de nanoemulsões termorreversíveis para administração nasal de fenitoína. Supervisor of ISAURA TEIXEIRA	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2017 - 2018	Análise de necessidades terapêuticas não satisfeitas pelos medicamentos comercializados em Portugal. Supervisor of ZAIDA DE SENA GOMES	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2017 - 2018	Otimização de formulações termorreversíveis para administração nasal de carbamazepina. Supervisor of Joana Ferreira	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2016 - 2017	Estudo da aceitabilidade de um veículo para preparações líquidas orais manipuladas na forma de solução autoemulsionante. Supervisor of MARISA CASTRO	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2016 - 2017	Otimização da Fase Oleosa de Nanoemulsões de Fenitoína. Supervisor of DIANA RITA MARTINS PEIXOTO	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2015 - 2016	O Papel dos Produtos Cosméticos em Dermatite Atópica. Supervisor of BOHDANA SERGIIVNA VOLOSHCHUK	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2015 - 2016	Preparações nasais com ação terapêutica no cérebro de sucesso – revisão de dados de farmacocinética clinica. Supervisor of RITA DANIELA BEIRÃO DOS SANTOS	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2015 - 2016	Inovação farmacêutica na era dos medicamentos genéricos. Supervisor of RICARDO MANUEL MARTINS RESENDE	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2015 - 2016	Identificação de opções terapêuticas não satisfeitas pelos medicamentos comercializados com Autorização de Introdução no Mercado em Portugal. Supervisor of ANA SOFIA MAGALHÃES ALVES	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2014 - 2015	Nanopartículas na entrega eficaz e segura de fármacos ao cérebro por via nasal. Supervisor of JOANA ALVES COUTINHO	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2014 - 2015	Aplicações Clínicas e Estratégias de Formulação da Insulina Intranasal. Supervisor of Cátia Maria Vaz Pereira Valente	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2014 - 2015	O uso racional de antibióticos em Cabo Verde: A perspetiva dos farmacêuticos da cidade da Praia. Supervisor of CARLOS DANIEL DOMINGOS SILVA	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2014 - 2015	Estudos de Formulação de Nanoemulsões de Fenitoína. Supervisor of RICARDO NUNO BRÍGIDO MADEIRA	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2013 - 2015	Development of (nano)pharmaceutical formulation-based platforms for intranasal delivery of CNS-active drugs. Supervisor of DANIEL ANTUNES VIEGAS	Farmácia (PhD) Universidade da Beira Interior, Portugal
2013 - 2014	Perceção e aplicação do novo paradigma Quality by Design na Indústria Farmacêutica em Portugal Supervisor of Ana Catarina Cadavez Pilão Garcia	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal
2013 - 2014	Modelos ex-vivo para avaliação da permeação de fármacos pelas vias nasal e rectal – revisão sistemática Supervisor of Miguel Ângelo Lopes Gonçalves	Ciências Farmacêuticas (Master) Universidade da Beira Interior, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/03/27	Pharmaceutical product development based on a Quality by Design approach Thesis Member	Ana Isabel de Oliveira Simões Martins (PhD) Universidade de Coimbra, Portugal
2022/12/19	Strategic and advancing regulatory science approach in pharmaceutical development of complex generic drug products. (Thesis) Arguer	Daniela Mariana Marques Zagalo (PhD) Universidade de Coimbra, Portugal
2022/07/28	Insights into the mechanisms of intracellular delivery of targeted liposomal doxorubicin/ceramides combinations and the importance to assess the nature of drug interaction beyond bulk tumor cells. (Thesis) Main arguer	Ana Filipa Fernandes da Cruz (PhD) Universidade de Coimbra, Portugal
2018	ß-glucan-based adjuvants for Hepatitis B vaccination: particulate design for prophylactic and therapeutic needs. (Thesis) Arguer	Edna Filipa Pais Soares (PhD) Universidade de Coimbra, Portugal
2018	Preclinical performance of vaginal semisolid products: technological and safety evaluations assuming physiologic parameters. Thesis Member	Rita Solange Monteiro Machado (PhD) Universidade da Beira Interior, Portugal
2016	Targeting nucleolin in lung cancer: Towards a personalized therapy. (Thesis) Arguer	Angela Filipa Valério Fernandes (PhD) Universidade de Coimbra, Portugal

Committee member

	Activity description Role	Institution / Organization
2019/10 - Current	Executive committee of CICS-UBI Member	Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal