???global.info.a_carregar???
Adriana O. Santos holds a degree in Pharmaceutical Sciences (2003) and a Ph.D. in Pharmacy (2009), specializing in Pharmaceutical Technology, from the University of Coimbra. Her doctoral thesis focused on targeted liposomes containing siRNA for the treatment of small cell lung cancer. Adriana was a postdoctoral researcher at Institut Curie in Paris (2009-2012), where she studied the intracellular signaling of Ral and RalGEFs in lung cancer cells. In 2012, Adriana O. Santos became Assistant Professor at the University of Beira Interior, Department of Medical Sciences, and a researcher at CICS-UBI (which will transition to RISE-Health, UBI, in 2025). Since 2015, Adriana has been a member of the scientific and pedagogical coordination committees of the Integrated Master’s Degree in Pharmaceutical Sciences and was recently appointed as its mobility coordinator. Adriana also coordinated the research group "Drug Discovery, Development, and Safety" (3DS) at CICS-UBI (2022-2024) and is a member of the research center’s executive committee. Adriana has (co)supervised two Ph.D. theses: one in Pharmaceutical Sciences (UBI, March 2021) and another in Chemical and Biological Sciences (UTAD, October 2024). Additionally, she has (co)supervised 46 master's dissertations and 6 undergraduate projects. Her current research primarily focuses on intranasal drug delivery targeting brain-related conditions. Adriana O. Santos has co-authored 43 peer-reviewed articles, with 25 published in the last 5 years (2020-2024). She has also contributed to 2 book chapters and over 80 communications at scientific conferences. Furthermore, she is listed as an inventor on a pending international patent. Adriana was the principal investigator of the project Intranasal Delivery of Simvastatin in Stroke awarded the "CICS-UBI Collaborative Project Awards" in 2021 and the proof-of-concept project funded by PO Centro titled Segesterone Acetate Innovative Nanoemulsion (SAIN). She has participated in 5 doctoral examination boards —3 times as an examiner and 2 as a committee member—and in scientific committees of international meetings.
Read full resume ↓
Identification

Personal identification

Full name
ADRIANA OLIVEIRA DOS SANTOS
Date of birth
1979/07/16
Gender
Female

Citation names

  • SANTOS, ADRIANA O.
  • Santos, A.O.; Santos A; O. Santos, A.

Author identifiers

Ciência ID
891C-417A-1534
ORCID iD
0000-0002-1224-9191
Researcher Id
H-4597-2011
Scopus Author Id
14049212000

Email addresses

  • asantos@fcsaude.ubi.pt (Professional)
  • aos@ubi.pt (Professional)

Telephones

Telephone
  • 275329079 (Professional)

Addresses

  • Faculdade de Ciências da Saúde, Av. Infante D. Henrique, 6200-506 , Covilhã, Covilhã, Portugal (Professional)

Websites

  • https://www.ubi.pt/Pessoa/aos | http://orcid.org/0000-0002-1224-9191 (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2009/10/29
Concluded
 Pharmacy (Doutoramento)
Major in Pharmaceutics
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Targeted Gene Silencing Therapy in Small Cell Lung Cancer" (THESIS/DISSERTATION)
 Distinção e Louvor (Approved with praise and disti
1997/10 - 2003/07/23
Concluded
 Pharmaceutical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 16 valores (16 values, out of 20)
Affiliation

Science

Category
Host institution 		Employer
2009/11/01 - 2012/10/31 Postdoc (Research) Institut Curie, France
Institut Curie, France
2009/08/17 - 2009/10/31 Visiting Researcher (Research) Institut Curie, France
2003/10/01 - 2007/09/30 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
2005/02/01 - 2005/12/21 Visiting Researcher (Research) UniversitätsSpital Zürich, Switzerland
2002/10/01 - 2002/12/20 Research Trainee (Research) Universidad de Salamanca, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2012/11/02 - Current Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/07 - Current Coordinator of the research group 3DS of CICS-UBI and inherently member of the executive committee of the same research unit. Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2013/01/01 - Current Integrated Member Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/10 - 2021/10 Vice-coordinator of the research group BCDR of CICS-UBI and inherently member of the executive committee of the same research unit. Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2022/06/01 - 2023/05/31 Segesterone Acetate Innovative Nanoemulsion (SAIN)
CENTRO-01-0145-FEDER-181231
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 European Union

Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2020/10/05 - 2021/07/06 CovidOUT - Spray to reduce the nasal transmission of coronavirus
CENTRO-01-02B7-FEDER-069358
Researcher
Health Products Research and Development Lda. , Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
European Development Fund

Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2017/04 - 2020/03 ICON - Interdisciplinary Challenges On Neurodegeneration
CENTRO-01-0145-FEDER-000013
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 European Commission
Concluded
2016 - 2019 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2012 Deciphering the networks leading to the activation of the Ral GTPases in human lung cancers, dependently or not on Ras
RS12/75-62
 Ligue Nationale Contre Le Cancer
2009/11 - 2011/10 The RAL-pathway as a key pathway and target in oncogenisis - From the RalGEFs, to the exocyst complex, to the executioners
Engt 2008005019
 Fondation de France
2003/10/01 - 2007/09/30 PROGRAMA DOUTORAL EM BIOLOGIA EXPERIMENTAL E BIOMEDICINA
SFRH/BD/11817/2003
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023/03/01 - 2024/02/29 Multifunctional Innovative NanoDevice for lung cancer therapy (MIND)
MIND
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Banco Santander Portugal
Ongoing
2023/02/01 - 2023/06/30 Nanoemulsão Inovadora para Tratamento Antimicrobiano (NITA)
NITA
Researcher
Universidade da Beira Interior, Portugal
 European Regional Development Fund
Concluded
2021/11/01 - 2022/10/31 Intranasal Delivery of Simvastatin in Stroke
UIDP/Multi/00709/2020
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde
Ongoing
Outputs

Publications

Book chapter
  1. Melo, Dora; Patrícia C. Pires; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Intranasal administration of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems. Elsevier, 2020.
    Published
  2. SANTOS, ADRIANA; Moreira, J.N.; Bimbo, L.M.; Gomes da Silva, L; Pedrososo de Lima, M. C.; Simões, S.. "Gene silencing therapy in small cell lung cancer – which agents, targets, and delivery systems?". In In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, edited by Jonathon G. Maldonado; Mikayla K. Cervantes, 1-50. Nova Science, 2009.
    Published
Journal article
  1. Inês Afonso; Ana R. Neves; Dalinda Eusébio; Tânia Albuquerque; Eric Vivès; Prisca Boisguérin; Adriana O. Santos; Ângela Sousa; Diana Costa. "Design of Experiments to Tailor the Potential of BSA-Coated Peptide Nanocomplexes for Temozolomide/p53 Gene Co-Delivery". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16111389.
    10.3390/pharmaceutics16111389
  2. Guedes, Romina A.; Grilo, Jorge H.; Carvalho, Andreia N.; Fernandes, Pedro M. P.; Ressurreição, Ana S.; Brito, Vanessa; SANTOS, ADRIANA O.; et al. Corresponding author: Guedes, Rita C.. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals 16 8 (2023): 1096. http://dx.doi.org/10.3390/ph16081096.
    Open access • Published • 10.3390/ph16081096
  3. Pires, Patrícia C.; Fernandes, Mariana; Nina, Francisca; Gama, Francisco; Gomes, Maria F.; Rodrigues, Lina E.; Meirinho, Sara; et al. Corresponding author: SANTOS, ADRIANA O.. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics 15 7 (2023): 1878. http://dx.doi.org/10.3390/pharmaceutics15071878.
    Open access • Published • 10.3390/pharmaceutics15071878
  4. Lima, Eurico; Barroso, Andreia G.; Ferreira, Octávio; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; SANTOS, ADRIANA O.; Reis, Lucinda V.. Corresponding author: SANTOS, ADRIANA O.. "Benz[e]indole-bearing aminosquaraine dyes: Which of the amines introduced into the squaric ring will be able to induce the best in vitro photodynamic effect?". Dyes and Pigments 215 (2023): 111239. http://dx.doi.org/10.1016/j.dyepig.2023.111239.
    Published • 10.1016/j.dyepig.2023.111239
  5. Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Nose-to-brain delivery of perampanel formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice". International Journal of Pharmaceutics 642 (2023): 123145. http://dx.doi.org/10.1016/j.ijpharm.2023.123145.
    10.1016/j.ijpharm.2023.123145
  6. Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting". Pharmaceutics 15 6 (2023): 1641. http://dx.doi.org/10.3390/pharmaceutics15061641.
    Open access • Published • 10.3390/pharmaceutics15061641
  7. Matias, Mariana; SANTOS, ADRIANA O.; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Fighting Epilepsy with Nanomedicines - Is This the Right Weapon?". Pharmaceutics 15 2 (2023): 306. http://dx.doi.org/10.3390/pharmaceutics15020306.
    Published • 10.3390/pharmaceutics15020306
  8. Vanessa Brito; SANTOS, ADRIANA O.; Gilberto Alves; Paulo Almeida; Samuel Silvestre. Corresponding author: Samuel Silvestre. "Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies". Molecules 27 18 (2022): 6126-6126. http://dx.doi.org/10.3390/molecules27186126.
    Published • 10.3390/molecules27186126
  9. João L. Serrano; Ana Maia; Adriana O. Santos; Eurico Lima; Lucinda V. Reis; Maria J. Nunes; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. Corresponding author: Paulo Almeida. "An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells". Molecules 27 18 (2022): 5779-5779. https://doi.org/10.3390/molecules27185779.
    10.3390/molecules27185779
  10. Meirinho, Sara; Rodrigues, Márcio; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration". Pharmaceutics 14 7 (2022): 1487. http://dx.doi.org/10.3390/pharmaceutics14071487.
    Open access • 10.3390/pharmaceutics14071487
  11. Gomes, Diana; Yaduvanshi, Shivani; Silvestre, Samuel; Duarte, Ana Paula; SANTOS, ADRIANA O.; Soares, Christiane P.; Kumar, Veerendra; Passarinha, Luís; Sousa, Ângela. Corresponding author: Sousa, Ângela. "Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells". Cancers 14 12 (2022): 2834. http://dx.doi.org/10.3390/cancers14122834.
    Published • 10.3390/cancers14122834
  12. Meirinho, Sara; Rodrigues, Márcio; Ferreira, Catarina L.; Oliveira, Rui Caetano; Fortuna, Ana; SANTOS, ADRIANA O.; Falcão, Amílcar; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel". International Journal of Pharmaceutics 622 (2022): 121853. http://dx.doi.org/10.1016/j.ijpharm.2022.121853.
    10.1016/j.ijpharm.2022.121853
  13. Catarina Canário; Mariana Matias; Vanessa Brito; Patrícia Pires; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. Corresponding author: Gilberto Alves. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579-3579. https://doi.org/10.3390/app12073579.
    10.3390/app12073579
  14. Pires, Patrícia C.; Rodrigues, Márcio; Alves, Gilberto; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics 14 3 (2022): 588. http://dx.doi.org/10.3390/pharmaceutics14030588.
    Open access • Published • 10.3390/pharmaceutics14030588
  15. Canário, Catarina; Matias, Mariana; Brito, Vanessa de; Cruz-Vicente, Pedro; Soeiro, Pedro; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "10ß-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro biological evaluation and in silico studies". Natural Product Research 36 24 (2022): 6459-6463. http://dx.doi.org/10.1080/14786419.2022.2039136.
    10.1080/14786419.2022.2039136
  16. Lima, Eurico; Barroso, Andreia G.; Sousa, Margarida A.; Ferreira, Octávio; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; et al. Corresponding author: SANTOS, ADRIANA O.. "Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents". European Journal of Medicinal Chemistry 229 (2022): 114071. http://dx.doi.org/10.1016/j.ejmech.2021.114071.
    Published • 10.1016/j.ejmech.2021.114071
  17. Pires, Patrícia C.; Fazendeiro, Ana C.; Rodrigues, Márcio; Alves, Gilberto; SANTOS, ADRIANA O.. Corresponding author: SANTOS, ADRIANA O.. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European Journal of Pharmaceutical Sciences 164 (2021): 105918. http://dx.doi.org/10.1016/j.ejps.2021.105918.
    Open access • Published • 10.1016/j.ejps.2021.105918
  18. Canário, Catarina; Matias, Mariana; Brito, Vanessa; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies". Molecules 26 9 (2021): 2687. http://dx.doi.org/10.3390/molecules26092687.
    Published • 10.3390/molecules26092687
  19. Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L.; Pavan, Fernando R.; Gomes, Clara S.B.; et al. "Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zinc(II) complexes". Journal of Inorganic Biochemistry 216 (2021): 111331. http://dx.doi.org/10.1016/j.jinorgbio.2020.111331.
    Published • 10.1016/j.jinorgbio.2020.111331
  20. Canário, Catarina; Matias, Mariana; de Brito, Vanessa; SANTOS, ADRIANA O.; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. Corresponding author: Alves, Gilberto. "Delta 9,11-Estrone derivatives as potential antiproliferative agents: synthesis, in vitro biological evaluation and docking studies". Comptes Rendus. Chimie 23 2 (2020): 201-217. http://dx.doi.org/10.5802/crchim.17.
    Published • 10.5802/crchim.17
  21. Lima, Eurico; Ferreira, Octávio; Silva, Joana F.; SANTOS, ADRIANA O.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Reis, Lucinda V.. Corresponding author: Reis, Lucinda V.. "Photodynamic activity of indolenine-based aminosquaraine cyanine dyes: Synthesis and in vitro photobiological evaluation". Dyes and Pigments 174 (2020): 108024. http://dx.doi.org/10.1016/j.dyepig.2019.108024.
    Published • 10.1016/j.dyepig.2019.108024
  22. Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization". European Journal of Pharmaceutical Sciences 141 (2020): 105099. http://dx.doi.org/10.1016/j.ejps.2019.105099.
    Open access • Published • 10.1016/j.ejps.2019.105099
  23. Lima, Eurico; Ferreira, Octávio; Gomes, Vanessa S.D.; Santos, Adriana O.; Boto, Renato E.; Fernandes, José R.; Almeida, Paulo; Silvestre, Samuel M.; Reis, Lucinda V.. "Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine". Dyes and Pigments 167 (2019): 98-108. http://dx.doi.org/10.1016/j.dyepig.2019.04.007.
    10.1016/j.dyepig.2019.04.007
  24. Ana Carolina Almeida Gonçalves; Márcio Rodrigues; Santos, A. O.; Gilberto Alves; Luís R. Silva. "Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits". Nutrients (2018): http://www.mdpi.com/2072-6643/10/11/1688.
    10.3390/nu10111688
  25. Vanessa Brito; Adriana O. Santos; Paulo Almeida; Samuel Silvestre. "Novel 4-azaandrostenes as prostate cancer cell growth inhibitors: Synthesis, antiproliferative effects, and molecular docking studies". Comptes Rendus Chimie (2018): https://doi.org/10.1016%2Fj.crci.2018.07.011.
    10.1016/j.crci.2018.07.011
  26. Pires, Patrícia C.; Santos, Adriana O.. "Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies". Journal of Controlled Release 270 (2018): 89-100. http://dx.doi.org/10.1016/j.jconrel.2017.11.047.
    Published • 10.1016/j.jconrel.2017.11.047
  27. Ferreira, A.; Santos, A.O.; Falcão, A.; Alves, G.. "In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs". Food and Chemical Toxicology 111 (2018): 84-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033366631&partnerID=MN8TOARS.
    10.1016/j.fct.2017.11.004
  28. Catarro, M.; Serrano, J.; Cavalheiro, E.; Ramos, S.; Santos, A.O.; Silvestre, S.; Almeida, P.. "Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies". Bioorganic and Medicinal Chemistry 25 16 (2017): 4304-4313. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021808666&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.06.009
  29. O Santos, A.; Parrini, M.C.; Camonis, J.. "RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases". PloS one 11 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85011808140&partnerID=MN8TOARS.
    10.1371/journal.pone.0154840
  30. Matias, M.; Campos, G.; Santos, A.O.; Falcão, A.; Silvestre, S.; Alves, G.. "Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones". Arabian Journal of Chemistry (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008352523&partnerID=MN8TOARS.
    10.1016/j.arabjc.2016.12.007
  31. Matias, M.; Campos, G.; Santos, A.O.; Falcão, A.; Silvestre, S.; Alves, G.. "Potential antitumoral 3,4-dihydropyrimidin-2-(1: H)-ones: synthesis, in vitro biological evaluation and QSAR studies". RSC Advances 6 88 (2016): 84943-84958. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987657546&partnerID=MN8TOARS.
    10.1039/c6ra14596e
  32. Antunes Viegas, D.; Rodrigues, M.; Francisco, J.; Falcão, A.; Alves, G.; Santos, A.O.. "Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method". European Journal of Pharmaceutical Sciences 89 (2016): 61-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964613921&partnerID=MN8TOARS.
    10.1016/j.ejps.2016.04.018
  33. Santos, D.; Medeiros-Silva, J.; Cegonho, S.; Alves, E.; Ramilo-Gomes, F.; Santos, A.O.; Silvestre, S.; Cruz, C.. "Cell proliferation effects of calix[4]arene derivatives". Tetrahedron 71 40 (2015): 7593-7599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940462179&partnerID=MN8TOARS.
    10.1016/j.tet.2015.07.077
  34. Levallet, G.; Bergot, E.; Antoine, M.; Creveuil, C.; Santos, A.O.; Beau-Faller, M.; De Fraipont, F.; et al. "High TUBB3 expression, an independent prognostic marker in patients with early non-small cell lung cancer treated by preoperative chemotherapy, is regulated by K-ras signaling pathway". Molecular Cancer Therapeutics 11 5 (2012): 1203-1213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862742698&partnerID=MN8TOARS.
    10.1158/1535-7163.MCT-11-0899
  35. Gomes-Da-Silva, L.C.; Santos, A.O.; Bimbo, L.M.; Moura, V.; Ramalho, J.S.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N.. "Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment". International Journal of Pharmaceutics 434 1-2 (2012): 9-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864129727&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.05.018
  36. Santos, A.O.; da Silva, L.C.G.; Bimbo, L.M.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Design of peptide-targeted liposomes containing nucleic acids". Biochimica et Biophysica Acta - Biomembranes 1798 3 (2010): 433-441. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749124054&partnerID=MN8TOARS.
    10.1016/j.bbamem.2009.12.001
  37. Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N.. "In vitro modulation of Bcl-2 levels in small cell lung cancer cells: Effects on cell viability". Brazilian Journal of Medical and Biological Research 43 10 (2010): 1001-1009. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149263712&partnerID=MN8TOARS.
    10.1590/S0100-879X2010007500099
  38. Santos, A.; Pereira, J. P.; Pedroso de Lima, M. C.; Simoes, S.; Moreira, J. N.. "SiRNA mediated clownregulation of Bcl-2 in small cell lung cancer cell lines - impact on protein level and cell viability". Ejc Supplements 6 9 (2008): 74-74.
    10.1016/S1359-6349(08)71460-5
  39. Moreira, J.N.; Santos, A.; Moura, V.; De Uma, M.C.P.; Simões, S.. "Non-viral lipid-based nanoparticles for targeted cancer systemic gene silencing". Journal of Nanoscience and Nanotechnology 8 5 (2008): 2187-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS.
    10.1166/jnn.2008.319
  40. Santos, A.; Sarmento-Ribeiro, A.B.; Pedroso De Lima, M.C.; Simões, S.; Moreira, J.N.. "Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer". Cytometry Part A 73 12 (2008): 1165-1172. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749165193&partnerID=MN8TOARS.
    10.1002/cyto.a.20634
  41. Moreira, J.N.; Santos, A.; Simões, S.. "Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality.". Reviews on recent clinical trials 1 3 (2006): 217-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-44849085132&partnerID=MN8TOARS.
    10.2174/157488706778250050

Intellectual property

Patent
  1. SANTOS, ADRIANA O.; Fernandes, Mariana Carvalho; Pires, Patrícia Sofia Cabral; Gilberto Lourenço Alves (BA10-57D6-DF00); Fazendeiro, Ana Carolina Maricoto; Nina, Francisca Matos Silva Pereira; Maria de Fátima da SilvaFerreira Gomes; Rodrigues, Lina Isabel Esteves. 2022. "SELF-EMULSIFYING COMPOSITION, PRODUCTION METHODS AND USES THEREOF".
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin - formulation development, in vitro characterization and in vivo pharmacokinetics FENS 2020 Virtual Forum
FENS
2020 Brain delivery of poorly soluble drugs: a proof-of-concept of phosphate esters as a way of increasing solubility and bioavailability Controlled Release Society Virtual Annual Meeting
Controlled Release Society
2019/11/14 Intranasal administration of fosphenytoin: assay development and validation and preliminary in vivo pharmacokinetic studies. III International Congress in Health Sciences Research.T owards Innovation and Entrepreneurship: Trends in Aging and Cancer.
CICS-UBI (Covilhã, Portugal)
2019/11 Sweet cherries phenolic-rich fractions exhibit anti-cancer properties and can modulate P-glycoprotein activity III International Congress in Health Sciences Research. Towards Innovation and Entrepreneurship: Trends in Aging and Cancer
CICS-UBI (Covilhã, Portugal)
2019/11 Proteosome inhibition of synthetic 5-5ubstituted (thio)barbiturates III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Aging and Cancer
CICS-UBI (Covilhã, Portugal)
2019/03/25 Oral self-emulsifying drug delivery system and intranasal nanoemulsions of phenytoin. 3rd European Conference on Pharmaceutics
(Bolonha, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/10/01 - 2024/10/18 Targeting Photodynamic Cancer Therapy with Squarine Cyanine Dyes (1st october 2019 -present)
Co-supervisor of Eurico Emanuel Avelar de Serpa Vieira Lima
Ciências Químicas e Biológicas (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2021 - 2022/03 Desenvolvimento de um ensaio para a avaliação ex vivo da toxicidade local de preparações nasais
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2021 - 2022/02 Desenvolvimento e otimização de nanoemulsões catiónicas
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2021 - 2022/01 Desenvolvimento de Micro e Nanoemulsões O/A para administração intranasal de Nestorona em Acidente Vascular Cerebral
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2017 - 2021/03/22 The promise of prodrugs and nanosystems in nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin.
Supervisor of Patrícia Sofia Cabral Pires
 Ciências Farmacêuticas (PhD)
Universidade da Beira Interior, Portugal
2017 - 2021/03 Estudo das condições de entrega intranasal de oligonucleótidos ao cérebro.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2019 - 2021/01 Revisão de modelos de epitélio nasal humano nos estudos pré-clínicos de segurança.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2020 - 2021 Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2020 - 2021 Desenvolvimento de microemulsões de fenitoína e fosfenitoína
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2021 Estudo das condições de entrega intranasal de oligonucleótidos ao cérebro
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019/11 Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019/10 Desenvolvimento de veículos palatáveis com boa aceitabilidade oral para a preparação de soluções autoemulsionantes para a via oral.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019/10 Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis.
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Synthesis and evaluation of 5-substituted (thio)barbiturates as proteasome inhibitors for cancer therapy.
Co-supervisor of Sara Hummeid
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Segurança e eficácia das microagulhas - revisão de ensaios clínicos.
Supervisor of José pedro Antunes Peres
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Desenvolvimento de uma emulsão O/A de sinvastatina para administração intranasal.
Supervisor of Mariana Carvalho Fernandes
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Desenvolvimento de uma formulação para administração de sRNA.
Co-supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Desenvolvimento de veículos palatáveis com boa aceitabilidade oral para a preparação de soluções autoemulsionantes para a via oral.
Supervisor of Beatriz Alexandra Correia Patrício
 Ciências Básicas Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis.
Supervisor of Liliana Teixeira dos Santos
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2018 - 2019 Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia.
Supervisor of Dora Fátima Neves de Melo
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Desenvolvimento de nanoemulsões termorreversíveis para administração nasal de fenitoína.
Supervisor of ISAURA TEIXEIRA
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Análise de necessidades terapêuticas não satisfeitas pelos medicamentos comercializados em Portugal.
Supervisor of ZAIDA DE SENA GOMES
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 Otimização de formulações termorreversíveis para administração nasal de carbamazepina.
Supervisor of Joana Ferreira
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2016 - 2017 Estudo da aceitabilidade de um veículo para preparações líquidas orais manipuladas na forma de solução autoemulsionante.
Supervisor of MARISA CASTRO
Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2016 - 2017 Otimização da Fase Oleosa de Nanoemulsões de Fenitoína.
Supervisor of DIANA RITA MARTINS PEIXOTO
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 O Papel dos Produtos Cosméticos em Dermatite Atópica.
Supervisor of BOHDANA SERGIIVNA VOLOSHCHUK
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Preparações nasais com ação terapêutica no cérebro de sucesso – revisão de dados de farmacocinética clinica.
Supervisor of RITA DANIELA BEIRÃO DOS SANTOS
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Inovação farmacêutica na era dos medicamentos genéricos.
Supervisor of RICARDO MANUEL MARTINS RESENDE
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 Identificação de opções terapêuticas não satisfeitas pelos medicamentos comercializados com Autorização de Introdução no Mercado em Portugal.
Supervisor of ANA SOFIA MAGALHÃES ALVES
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Nanopartículas na entrega eficaz e segura de fármacos ao cérebro por via nasal.
Supervisor of JOANA ALVES COUTINHO
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Aplicações Clínicas e Estratégias de Formulação da Insulina Intranasal.
Supervisor of Cátia Maria Vaz Pereira Valente
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 O uso racional de antibióticos em Cabo Verde: A perspetiva dos farmacêuticos da cidade da Praia.
Supervisor of CARLOS DANIEL DOMINGOS SILVA
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 Estudos de Formulação de Nanoemulsões de Fenitoína.
Supervisor of RICARDO NUNO BRÍGIDO MADEIRA
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2013 - 2015 Development of (nano)pharmaceutical formulation-based platforms for intranasal delivery of CNS-active drugs.
Supervisor of DANIEL ANTUNES VIEGAS
 Farmácia (PhD)
Universidade da Beira Interior, Portugal
2013 - 2014 Perceção e aplicação do novo paradigma Quality by Design na Indústria Farmacêutica em Portugal
Supervisor of Ana Catarina Cadavez Pilão Garcia
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 Modelos ex-vivo para avaliação da permeação de fármacos pelas vias nasal e rectal – revisão sistemática
Supervisor of Miguel Ângelo Lopes Gonçalves
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/03/27 Pharmaceutical product development based on a Quality by Design approach
Thesis Member
 Ana Isabel de Oliveira Simões Martins (PhD)
Universidade de Coimbra, Portugal
2022/12/19 Strategic and advancing regulatory science approach in pharmaceutical development of complex generic drug products.
(Thesis) Arguer
 Daniela Mariana Marques Zagalo (PhD)
Universidade de Coimbra, Portugal
2022/07/28 Insights into the mechanisms of intracellular delivery of targeted liposomal doxorubicin/ceramides combinations and the importance to assess the nature of drug interaction beyond bulk tumor cells.
(Thesis) Main arguer
 Ana Filipa Fernandes da Cruz (PhD)
Universidade de Coimbra, Portugal
2018 ß-glucan-based adjuvants for Hepatitis B vaccination: particulate design for prophylactic and therapeutic needs.
(Thesis) Arguer
 Edna Filipa Pais Soares (PhD)
Universidade de Coimbra, Portugal
2018 Preclinical performance of vaginal semisolid products: technological and safety evaluations assuming physiologic parameters.
Thesis Member
 Rita Solange Monteiro Machado (PhD)
Universidade da Beira Interior, Portugal
2016 Targeting nucleolin in lung cancer: Towards a personalized therapy.
(Thesis) Arguer
 Angela Filipa Valério Fernandes (PhD)
Universidade de Coimbra, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/10 - Current Executive committee of CICS-UBI
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal