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Sara Vaz holds a BSc in Genetics and Biotechnology from the University of Trás-os-Montes and Alto Douro (2010-2013) and a MSc in Cellular and Molecular Biology from the University of Coimbra (2013-2015). Currently, she is a PhD student from the Instituto de Ciências Biomédicas Abel Salazar (University of Porto) developing her work at the Ageing and Aneuploidy Group (i3S), under the supervision of Dr. Elsa Logarinho. She is mainly interested in understanding / exploring the molecular signatures of chronological ageing for their implications in cancer and ageing therapies.
Identification

Personal identification

Full name
Sara Vaz

Citation names

  • Vaz, Sara
  • Vaz, S

Author identifiers

Ciência ID
891F-BDB6-F90C
ORCID iD
0000-0002-9104-3254

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2016/01/01 - 2016
Ongoing
 Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential" (THESIS/DISSERTATION)
2015
Concluded
 Biologia Celular e Molecular (Mestrado)
Major in Área de especialização: Biologia Molecular e Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential" (THESIS/DISSERTATION)
 18 valores
2013
Concluded
 Genética e Biotecnologia (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Deteção e Caraterização do Papilomavírus humano em amostras citológicas de mulheres de São Tomé e Príncipe." (THESIS/DISSERTATION)
 15 valores
Affiliation

Others

Category
Host institution 		Employer
2016 - Current PhD Student Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
(...)
2013/09/01 - 2015/09/18 Master Student Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2014/03/10 - 2014/04/11 Graduated Student in a Laboratorial Rotation Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/01/20 - 2014/02/03 Graduated Student in a Laboratorial Rotation Universidade de Coimbra Faculdade de Medicina, Portugal
2012/07/12 - 2012/08/31 Undergraduate student Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
Projects

Grant

Designation Funders
2018/07/26 - 2021/07/27 In vivo amelioration of AGE-associated haLlmarkS by tranScriptional modulation (AGELeSS)
PTDC/BIA-CEL/31120/2017
PhD Student Fellow
2016/06/15 - 2019/10/31 Ageing: cells losing their mitotic fitness and chromosome balance
PTDC/BEX-BCM/2090/2014
PhD Student Fellow
2016/01/01 - 2018/12/31 Advancing cancer research: from basic knowledgment to application
NORTE-01-0145-FEDER-000029
PhD Student Fellow
Outputs

Publications

Book chapter
  1. Macedo J.C; Vaz, Sara; Elsa Logarinho. "Mitotic dysfunction associated with ageing hallmarks.". 2017.
    10.1007/978-3-319-57127-0_7
Conference poster
  1. Vaz, Sara; Macedo J.C; Elsa Logarinho. "FoxM1 inhibition induces a pro-apoptotic gene signature in cancer cell anti-mitotic chemotherapy". Paper presented in A Matter of Life or Death: Mechanisms, Models and Therapeutic Opportunities, 2020.
  2. Vaz, Sara; Macedo J.C; Elsa Logarinho. "FoxM1 inhibition-driven aging signature in cancer cells improves sensitivity to anti-mitotic chemotherapeutics". Paper presented in Mitotic and Meiotic Cell Cycle control and execution, 2019.
  3. Vaz, Sara; Macedo J.C; Elsa Logarinho. "Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential". Paper presented in i3S 6th ANNUAL MEETING, 2017.
  4. Vaz, Sara; Macedo J.C; Elsa Logarinho. "Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential.". Paper presented in 2nd Annual MCBiology Symposium: Orchestrating life, from molecules to cells., 2016.
  5. Vaz, Sara; Macedo J.C; Elsa Logarinho. "Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential.". Paper presented in i3S 5th ANNUAL MEETING, 2016.
  6. Vaz, Sara; Macedo J.C; Elsa Logarinho. "FoxM1 accounts for increased sensitivity to chemotherapy with anti-mitotics in human aged cells.". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015.
  7. Vaz, Sara; Macedo J.C; Elsa Logarinho. "FoxM1 in aging and cancer". Paper presented in i3S 4th ANNUAL MEETING, 2014.
  8. Vaz, Sara; Macedo J.C; Elsa Logarinho. "FoxM1 in aging and cancer.". Paper presented in i3S 4th ANNUAL MEETING, 2014.
Journal article
  1. Ghazaryan N; Movsisyan N; Macedo JC; Vaz, Sara; Ayvazyan N; Pardo L; Elsa Logarinho. "The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model". (2019): http://dx.doi.org/10.1007/s10637-019-00734-2.
    10.1007/s10637-019-00734-2
  2. Shukla, S.; Milewski, D.; Pradhan, A.; Rama, N.; Rice, K.; Le, T.; Flick, M.J.; et al. "The FOXM1 inhibitor RCM-1 decreases carcinogenesis and nuclear b-catenin". Molecular Cancer Therapeutics 18 7 (2019): 1217-1229. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069266373&partnerID=MN8TOARS.
    10.1158/1535-7163.MCT-18-0709
  3. Joana Catarina Macedo; Vaz, Sara; Bjorn Bakker; Rui Ribeiro; Petra Lammigje Bakker; Jose Miguel Escandell; Miguel Godinho Ferreira; et al. "FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence". (2018): http://dx.doi.org/10.1038/s41467-018-05258-6.
    10.1038/s41467-018-05258-6
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/11 FoxM1 inhibition-driven aging signature in cancer cells improves sensitivity to anti-mitotic chemotherapeutics i3S 7th ANNUAL MEETING
Instituto de Investigação e Inovação em Saúde (Póvoa de Varzim, Portugal)
2018/11 FoxM1 inhibition-driven aging signature in cancer cells improves sensitivity to anti-mitotic chemotherapeutics The Secret Life of the Cell – MCBiology PhD Symposium.
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2018/05 Age-dependent sensitivity to anti-mitotics: the role of FoxM1 and its therapeutic potential 1st PhDay at i3S | From bench to stage, from desk to forum.
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2016/01 Age-dependent sensitivity to anti-mitotics 5th CIMAGO CONGRESS
Universidade de Coimbra (Coimbra, Portugal)
2015/03 FoxM1 accounts for increased sensitivity of human aged cells to chemotherapy with anti-mitotics. VII Jornadas Nacionais de Genética e Biotecnologia
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2013/02 Deteção e caraterização do Papilomavírus humano (HPV) em amostras citológicas de mulheres de São Tomé e Príncipe. V Jornadas Nacionais de Genética e Biotecnologia
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2018 1st i3S PhDay (2018/05/30)
Conference (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 2nd Annual MCBiology Symposium: Orchestrating life, from molecules to cells. (2016/11/17 - 2016/11/17)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2013 V Jornadas Nacionais de Genética e Biotecnologia (2013/02/20 - 2013/02/22)
Conference (Member of the Organising Committee)
 Universidade de Trás-os-Montes e Alto Douro, Portugal
2012 - 2012 IV Jornadas Nacionais de Genética e Biotecnologia (2012/03/01 - 2012/03/03)
Conference (Member of the Organising Committee)
 Universidade de Trás-os-Montes e Alto Douro, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/04 - 2018/04 Volunteer at “Mostra da U.Porto”
Exhibition
 Mostra da U.Porto 2018
Universidade do Porto, Portugal
2017/06/26 - 2017/06/28 Hands-on Course - Introduction to Biological Data Analysis with R.
Workshop
 Introduction to Biological Data Analysis with R.
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/03/10 - 2016/03/12 Round Table of Alumni.
Round table
 VIII Jornadas Nacionais de Genética e Biotecnologia
Universidade de Trás-os-Montes e Alto Douro, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2018/08/03 Spotlight about our paper Macedo et al., 2018. Público

Mentoring / Tutoring

Topic Student name
2019/10 - 2019/11 Aleksandra Fesiuk
2015/01 - 2015/02 Valter Silva
Distinctions

Award

2015 Best oral communication in the VII Jornadas Nacionais de Genética e Biotecnologia, UTAD, Vila Real, Portugal, 26-28 March 2015
Universidade de Trás-os-Montes e Alto Douro, Portugal