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Identification

Personal identification

Full name
Daniela Filipa Domingues Santo
Date of birth
1993/11/27
Gender
Female

Citation names

  • Santo, Daniela

Author identifiers

Ciência ID
8A19-82C0-7D65
ORCID iD
0000-0003-4183-6464

Email addresses

  • dsanto@dem.uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Exact Sciences - Chemical Sciences - Polymer Science
  • Engineering and Technology - Materials Engineering - Coating and Films

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2017/10 - 2023/07/17
Concluded
 Experimental Biology and Biomedicine (specialty in Biotechnology and Health) (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
"Gene therapy mediated by glycopolymers-based nanocarriers in combination with chemotherapeutic drugs as a potential therapeutic strategy for hepatocellular carcinoma " (THESIS/DISSERTATION)
2014/09 - 2017/01
Concluded
 Biochemistry (Mestrado integrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Avaliação da capacidade de transporte e entrega de material genético associada a diferentes nanossistemas de base polimérica" (THESIS/DISSERTATION)
 18
2011/09 - 2014/07
Concluded
 Medicinal Chemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2022/11 - Current Researcher (Research) Universidade de Coimbra, Portugal
Centre for Mechanical Engineering, Materials and Processes, Portugal
2022/04/18 - 2022/10/18 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2017/09 - 2023 PhD student Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Projects

Contract

Designation Funders
2023/11 - Current Agenda Drivolution - Transição para a fábrica do futuro
02/C05-i01.02/2022.PC644913740-00000022
Post-doc
2022/11/01 - 2023/06/30 i9LOGO: Inovação no desenvolvimento e produção de Logotipos para o automóvel
POCI-01-0247-FEDER-072607
Research Fellow
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluded
2022/11 - 2023/06/30 ActiveStent Funcionalização Sustentável de Stents para Prevenção de Infeções do Trato Urinário
CENTRO-01-0145-FEDER-181221
Other
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
2022/04/18 - 2022/10/18 Engineering CAR T cells by a cost-effective non-viral gene delivery method
BFK2021-APCL
Research Fellow
Associação Portuguesa Contra a Leucemia
Ongoing
2018/07/01 - 2022/06/30 Desenvolvimento de um nanossistema inovador para mediar uma estratégia terapêutica combinada e multi-alvo para o carcinoma hepatocelular
PTDC/BTM-MAT/30916/2017
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/10/01 - 2022/03/31 A novel polymeric micelle formulation to mediate combined immunogene therapy and chemotherapy for hepatocellular carcinoma
SFRH/BD/132601/2017
PhD Student Fellow
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Cordeiro, Rosemeyre; Santo, Daniela; Farinha, Dina; Serra, Arménio; Coelho, Jorge; Faneca, Henrique. "High biological activity mediated by a tailor-made tri-block copolymer-based-nanovector". Paper presented in 5th Portuguese Meeting on Bioengineering, Coimbra, 2017.
    Published
Conference poster
  1. Cruz, Sandra; Santo, Daniela; Pereira, Patrícia; Rodrigues, Lisa ; Gonçalves, Teresa; I. Carvalho; Henriques, Mariana; Cavaleiro, Albano; Carvalho, Sandra. "Sustainable functionalization of stents to prevent urinary tract infections". Paper presented in SICT 2023 Surfaces, Interfaces and Coatings Technologies International conference, 2023.
  2. Santo, Daniela; Cruz, Sandra; Pereira, Patrícia; Rodrigues, Lisa ; Gonçalves, Teresa; I. Carvalho; Henriques, Mariana; Cavaleiro, Albano; Carvalho, Sandra. "Sustainable functionalization of stents to prevent urinary tract infections". Paper presented in Materiais, 2023.
  3. Santo, Daniela. "Surface Engineering: a powerful tool for biomedical applications". Paper presented in BIO'n'TEQ: Mostra Tecnológica de Biotecnologia,, 2023.
  4. Santo, Daniela; Mendonça, P.; Lima, Mafalda; Cordeiro, Rosemeyre A; Serra, Arménio; Coelho, Jorge FJ; Faneca, Henrique. "Efficient gene delivery promoted byPEGylated poly(2-aminoethyl methacrylate hydrochloride)-basednanosystems". Paper presented in 31st Nano Congress for FutureAdvancements, 2019.
  5. Cordeiro, Rosemeyre A; Santo, Daniela; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "High gene delivery efficiency of a novel nanosystem based on a synergistic polymeric combination". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018.
  6. Santo, Daniela; Cordeiro, Rosemeyre A; Serra, Arménio; Coelho, Jorge FJ; Faneca, Henrique. "High gene delivery efficiency promoted by a combined polymeric-based nanosystem". Paper presented in IEEE 5th Portuguese Meeting on Bioengineering (ENBENG)., 2017.
  7. Cordeiro, Rosemeyre; Santo, Daniela; Farinha, Dina Pereira Alves; Serra, Arménio; Coelho, Jorge; Faneca, Henrique. "High biological activity mediated by a tailor-made tri-block copolymer-based on nanovector". Paper presented in 5th Portuguese Meeting on Bioengineering, 2017.
Journal article
  1. Devesa, S.; Cavaleiro, D.; Santo, D.; Gavinho, S.; Cunha, A. F.; Santos, P.; Carvalho, S.. "Boric acid-free electrodeposition process and solar–thermal energy conversion of and Ni-carbon black nanocomposite coatings". Journal of Materials Research (2024): http://dx.doi.org/10.1557/s43578-024-01477-4.
    10.1557/s43578-024-01477-4
  2. Santo, Daniela; Castro, José D.; Benzarti, Zohra; Cruz, Sandra; Carvalho, António P.; Cavaleiro, Albano; Carvalho, S.. "Assessing mechanical properties and stability of silver-doped carbon-coated urethral stent application". Surface and Coatings Technology 487 (2024): 130988. http://dx.doi.org/10.1016/j.surfcoat.2024.130988.
    10.1016/j.surfcoat.2024.130988
  3. André V. Fontes; Patricia Freitas Rodrigues; Santo, Daniela; A.S. Ramos. "Exploring the Influence of the Deposition Parameters on the Properties of NiTi Shape Memory Alloy Films with High Nickel Content". Coatings (2024): https://www.mdpi.com/2079-6412/14/1/138.
    10.3390/coatings14010138
  4. Daniela Santo; Patrícia V. Mendonça; Arménio C. Serra; Jorge F.J. Coelho; Faneca H; Santo, Daniela; Mendonça, Patrícia; et al. "Targeted downregulation of MYC mediated by a highly efficient lactobionic acid-based glycoplex to enhance chemosensitivity in human hepatocellular carcinoma cells". International Journal of Pharmaceutics (2023): 122865-122865. http://dx.doi.org/10.1016/j.ijpharm.2023.122865.
    Under revision • 10.1016/j.ijpharm.2023.122865
  5. Daniela Santo; Rosemeyre Cordeiro; Patrícia V. Mendonça; Armenio Serra; Jorge Coelho; Faneca H. "Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel". Biomacromolecules (2023): http://dx.doi.org/10.1021/acs.biomac.2c01329.
    10.1021/acs.biomac.2c01329
  6. Ribeiro, Jessica P.M.; Mendonça, Patrícia V.; Santo, Daniela; De Bon, Francesco; Faneca, Henrique; Guliashvili, Tamaz; Coelho, Jorge F.J.; Serra, Arménio C.. "Expanding the use of affordable CuSO4·5H2O in ATRP techniques in homogeneous media". Polymer 241 (2022): 124526. http://dx.doi.org/10.1016/j.polymer.2022.124526.
    10.1016/j.polymer.2022.124526
  7. Costa, Diana; Santo, Daniela; Domingues, Cátia; Veiga, Francisco; Faneca, Henrique; Figueiras, Ana. "Recent advances in peptide-targeted micelleplexes: Current developments and future perspectives". International Journal of Pharmaceutics 597 (2021): 120362. http://dx.doi.org/10.1016/j.ijpharm.2021.120362.
    10.1016/j.ijpharm.2021.120362
  8. Santo, Daniela; Mendonça, Patrícia V.; Lima, Mafalda S.; Cordeiro, Rosemeyre A.; Cabanas, Luis; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "Poly(ethylene glycol)-block-poly(2-aminoethyl methacrylate hydrochloride)-Based Polyplexes as Serum-Tolerant Nanosystems for Enhanced Gene Delivery". Molecular Pharmaceutics 16 5 (2019): 2129-2141. http://dx.doi.org/10.1021/acs.molpharmaceut.9b00101.
    Published • 10.1021/acs.molpharmaceut.9b00101
  9. Santo, Daniela; Cordeiro, Rosemeyre A.; Sousa, Ana; Serra, Arménio; Coelho, Jorge F.J.; Faneca, Henrique. "Combination of Poly[(2-dimethylamino)ethyl methacrylate] and Poly(ß-amino ester) Results in a Strong and Synergistic Transfection Activity". Biomacromolecules 18 10 (2017): 3331-3342. http://dx.doi.org/10.1021/acs.biomac.7b00983.
    10.1021/acs.biomac.7b00983
  10. Cordeiro, Rosemeyre A.; Santo, Daniela; Farinha, Dina; Serra, Arménio; Faneca, Henrique; Coelho, Jorge F.J.. "High transfection efficiency promoted by tailor-made cationic tri-block copolymer-based nanoparticles". Acta Biomaterialia 47 (2017): 113-123. http://dx.doi.org/10.1016/j.actbio.2016.10.015.
    10.1016/j.actbio.2016.10.015
Thesis / Dissertation
  1. Santo, Daniela. "Avaliação da capacidade de transporte e entrega de material genético associada a diferentes nanossistemas de base polimérica". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2016. http://hdl.handle.net/10316/41482.
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/09/29 - Current European Researchers' Night
2023/09/25 - 2033/09/29 5th International Practical Biofilm Course and Symposium: Biofilms as Promotors of Dormancy and Antimicrobial Tolerance
Workshop
 5th International Practical Biofilm Course and Symposium: Biofilms as Promotors of Dormancy and Antimicrobial Tolerance
Distinctions

Award

2019 Best poster award - 31st Nano Congress for Future Advancements, 2019.