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Identification

Personal identification

Full name
Inês Margarida Vieira da Silva

Author identifiers

Ciência ID
8A1D-AA13-FA0B
Education
Degree Classification
2023/02/02 - 2023/02/09
Concluded
 Course on Modules 9, 10 and 11 (Function B) (Pós-Graduação)
Congento Consortium for Genetically Tractable Organisms, Portugal
2019/10/17
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Bioquímica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Aquaporins in metabolic syndrome: new targets for drug discovery " (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2018/03 - 2018/09
Concluded
 Atualização Teórico e Prático em Ciências de Animais de Laboratório - Categoria B (Function A) (Pós-Graduação)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2008 - 2010
Concluded
 Biologia Celular e Biotecnologia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estruturas secretoras e actividades biocidas em espécies de Hypericum (Clusiaceae) da flora portuguesa" (THESIS/DISSERTATION)
2005 - 2008
Concluded
 Biologia Celular e Biotecnologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2023/06/01 - Current Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/09/01 - 2022/12/31 Visiting Researcher (Research) The Pennsylvania State University, United States
2019/11 - 2022/09/30 Researcher (Research) Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
2019/03 - 2019/06 Visiting Researcher (Research) Universitat de Barcelona Institut de Biomedicina, Spain
2018/09 - 2019/03 Visiting Researcher (Research) Universidade de Lisboa Instituto de Saúde Ambiental, Portugal
2018/03 - 2018/07 Visiting Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/09 - 2017/12 Visiting Researcher (Research) Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca, Spain

Others

Category
Host institution 		Employer
2015/09 - 2019/08 Aluno de Doutoramento Associação para a Inovação e Desenvolvimento da FCT, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/03 - 2015/08 Bolseiro Instituto Nacional de Investigação Agrária e Veterinária, Portugal
Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2013/03 - 2015/02 Bolseiro Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2012/02 - 2013/02 Bolseiro Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Projects

Grant

Designation Funders
2023/03/26 - Current Aquaporin-9 Immuno-Therapy: a new strategy for reducing inflammation
2022.06601.PTDC
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2021 Impact of LPS-induced chronic inflammation on aquaporins expression in piglets
2020 INOV-17
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal
Concluded
2015/09/01 - 2019/08/31 Aquaporins in metabolic syndrome: new targets for drug discovery
SFRH/BD/113634/2015
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2018 Characterization of transmembrane protein channels in the small intestine of piglets fed on amino acids enriched diets: a translational model to humans
2017 INOV-17
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal
Concluded
2016 - 2017 Modulation of aquaporin gene expression by n-3 long-chain PUFA lipid structures in white and brown adipose tissue from hamsters
2016 INOV-20
Researcher
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal
Concluded

Contract

Designation Funders
2019/11/18 - Current Targeting aquaporin-3 as a novel therapeutic approach for melanoma
PTDC/BTM-SAL/28977/2017
Post-doc
Associação da faculdade de farmácia para a investigação e desenvolvimento, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2023/06/01 - 2029/05/31 Aquaporin-9 Immuno-Targeting: a new strategy for inflammation therapeutics
2022.03691.CEECIND/CP1743/CT0001
10.54499/2022.03691.CEECIND/CP1743/CT0001
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Inibição da aquaporina-3 como uma nova abordagem terapêutica para o melanoma
PTDC/BTM-SAL/28977/2017
Membro da Equipa
Fundação para a Ciência e a Tecnologia
Ongoing
2015/03/01 - 2015/08/31 InovCast - Inovação na cadeia de produção da castanha: competitividade e sustentabilidade
PRODER 53593
Research Fellow
Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2013/03/01 - 2015/02/28 Characterization of the pinewood nematode/Pinus system: a phytochemical and histopathological approach
PTDC/AGRCFL/120184/2010
Research Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade de Lisboa Centro de Biotecnologia Vegetal, Portugal
2012/02/01 - 2013/01/31 Role of a patatin-like lipid acyl hydrolase in membrane degradation under water deficit: Integrating molecular and physiological approaches in Arabidopsis"
PTDC/AGR-AAM/103721/2008
Research Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Outputs

Publications

Book chapter
  1. da Silva, Inês V.; Soveral, Graça. "Aquaporins in Obesity". In Advances in Experimental Medicine and Biology, 289-302. Springer Nature Singapore, 2023.
    10.1007/978-981-19-7415-1_20
  2. da Silva, Inês V.; Soveral, G.. "Aquaporins in obesity". In Aquaporins. Springer, 2017.
    Published • 10.1007/978-94-024-1057-0_15
Conference abstract
  1. Pimpão, Catarina; da Silva, Inês V.; Soveral, Graça. "Investigating the role of aquaporins as transceptors in cancer". Paper presented in FEBS-IUBMB-ENABLE, 1st International Molecular Biosciences PhD and Postdoc Conference, Seville, 2023.
    Accepted • 10.1002/2211-5463.13608
  2. Castro, Rita; da Silva, Inês V.; Gullette, Sean; Florindo, Cristina; Huang, Neil; Neuberger, Thomas; Ross, A. Catharine; Soveral, Graça. "Nutritional Ketosis, Aquaporins, and Energy Homeostasis". Paper presented in NUTRITION 2023, Boston, 2022.
    Published • 10.1093/cdn/nzac057.004
  3. Matos, Andreia; Carolina Santos, Ana; da Silva, Inês V.; Pereira da Silva, Alda; Portelinha, Ana; Clara Bicho, Maria; José Areias, Maria; et al. "VEGFR/SFlt1 is associated to disruption of oxidative stress leading to endothelial dysfunction in preeclampsia". 2021.
    Published • 10.1016/j.preghy.2021.07.080
  4. da Silva, Inês V.; Pimpão, Catarina; Mósca, Andreia F; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, Annette; Aureliano, Manuel; Soveral, G.. "Polyoxotungstates inhibit aquaporin-3 and impair melanoma cell migration". 2021.
    Published • 10.1002/2211-5463.13205
  5. Da Silva, I.V.; Matos, A.; Pereira Da Silva, A.; Santos, A.; Portelinha, A.; José Areias, M.; Soveral, G.; et al. "Cardiovascular risk may be predicted by p22phox and nitric oxide synthase polymorphisms in women with previous pregnancy hypertension". Paper presented in 29th European Meeting on Hypertension and Cardiovascular Protection from the European Society of Hypertension, Milan, 2019.
    Published • 10.1097/01.hjh.0000573056.97903.4d
  6. da Silva, Inês V.; Cardoso, Carlos; Martinez-Banaclocha, Helios; Casini, Angela; Pelegrin, Pablo; Soveral, Graça. "Aquaporin-3 is involved in NLRP3-inflammasome priming and activation". Paper presented in 12th EBSA/10th ICBP-IUPAP Congress, Madrid, 2019.
    Published • 10.1007/s00249-019-01373-4
  7. da Silva, Inês V.; Cardoso, Carlos; Martinez-Banaclocha, Helios; Casini, Angela; Pelegrin, Pablo; Soveral, Graça. "Aquaporins in immune cells: contribution for inflammasome priming and activation". Paper presented in The 44th FEBS Congress, Cracóvia, 2019.
    Published • 10.1002/2211-5463.12675
  8. Da Silva, I.V.; Barroso, M.; Moura, T.; Castro, R.; Soveral, G.. "Aquaporins and hypomethylation in endothelia: implications in cardiovascular disease". Paper presented in The 43rd FEBS Congress, Prague, 2018.
    Published • 10.1002/2211-5463.12449
  9. Méndez-Giménez, Leire; Camões, Sérgio Póvoas; Frühbeck, Gema; Rodríguez, Amaia; Miranda, Joana; Soveral, Graça. "Insights on aquaporins involvement in obesity-induced inflammation in pancreatic ß-cells". Paper presented in 19th biennial meeting for the Society for Free Radical Research International, Lisboa, 2018.
    Published • 10.1016/j.freeradbiomed.2018.04.203
  10. da Silva, I.V; Barroso, M.; Moura, T.; Castro, R.; Soveral, G.; da Silva, Inês V.; Rodrigues, C.. "Biophysical assessment of endothelial aquaporins as water and glycerol channels". Paper presented in 19th International Union of Pure Applied Biophysics and 11th European Biophysical Societies’ Association congress, Edinburgh, 2017.
    Published • 10.1007/s00249-017-1222-x
  11. Vieira da Silva, I.; Nogueira, T.; Ascensão, L.. "New reports on secretory structures of vegetative and floral organs of Hypericum elodes(Hypericaceae)". 2015.
    10.1017/s143192761401397x
  12. Da Silva, I.V.; Barbosa, P.; Mota, M.; Ascensão, L.; da Silva, Inês V.. "Histological Changes in Stems of Pinus sylvestris Seedlings Infected with a Virulent Isolate of the Pinewood Nematode Bursaphelenchus xylophilus". Paper presented in International Conference on Microscopy and Microanalysis and XLVIII Congress of the Portuguese Microscopy Society, Porto, 2015.
    Published • 10.1017/S1431927615014294
  13. Faria, J.M.S.; Sena, I.; Maleita, C.M.; Vieira da Silva, I.; Ascensão, L.; Abrantes, I.; Bennett, R.N.; Mota, M.; Figueiredo, A.C.. "In vitro co-culture of Solanum tuberosum hairy roots with Meloidogyne chitwoodi: Structure, growth and production of volatiles". 2014.
    10.1007/s11240-014-0504-6
  14. Vieira da Silva, I.; Nogueira, T.; Ascensão, L.. "Secretory Structures in Vegetative and Floral Organs of Hypericum perfoliatum". 2013.
    10.1017/s1431927613000846
Conference paper
  1. da Silva, Inês V.; Faria, J. M. S.. "Essential oils active against Anisakis nematode larvae". Paper presented in Medical Sciences Forum, 2021.
    Published
Conference poster
  1. Silva, Patricia M.; da Silva, Inês V.; Sarmento, Maria J.; Carvalho, Filomena A.; Soveral, Graça; Correia dos Santos, Nuno. "AQP3 and AQP5 silencing promotes changes in cell-cell adhesion and biomechanical properties of pancreatic cancer cells". Paper presented in 20th IUPAB Congress, 45th Annual SBBf Meeting, and 50th Annual SBBq Meeting, 2021.
  2. Silva, Andreia G.; da Silva, Inês V.; Casini, Angela; Soveral, Graça. "Gold compounds’ inhibitory effect on Aquaporin-3 impairs melanoma cell migration". Paper presented in XXI SPB - National Congress of Biochemistry, 2021.
  3. Silva, Patricia M.; da Silva, Inês V.; Sarmento, M. J.; Carvalho, F. A.; Soveral, Graça; Correia dos Santos, Nuno. "Effects of aquaporin-3 and aquaporin-5 silencing on pancreatic cancer cell biomechanics and cell-cell adhesion". Paper presented in 7th International Iberian Biophysics Congress, 2021.
  4. Pimpão, Catarina; da Silva, Inês V.; Mósca, Andreia F; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, Annette; Aureliano, Manuel; Soveral, Graça. "Biophysical evaluation of polyoxotungstates on aquaporin-3 permeability and melanoma cell migration". Paper presented in 7th International Iberian Biophysics Congress, 2021.
  5. da Silva, Inês V.; Cardoso, Carlos; Méndez-Giménez, Leire; Camões, Sérgio Póvoas; Miranda, Joana P.; Frühbeck, Gema; Rodríguez, Amaia; Soveral, Graça. "Biophysical and biological characterization of pancreatic AQP7 and AQP12 as water and glycerol channels and its implication in inflammation". Paper presented in 7th International Iberian Biophysics Congress, 2021.
  6. da Silva, Inês V.; Pimpão, Catarina; Mósca, Andreia F; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, Annette; Aureliano, Manuel; Soveral, Graça. "Polyoxotungstates inhibit aquaporin-3 and impair melanoma cell migration". Paper presented in The 45th FEBS Congress, Ljubljana, 2021.
  7. da Silva, Inês V.; Díaz-Sáez, Francisco; Zorzano, A.; Gumà, A.; Camps, Marta; Soveral, Graça. "Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes". Paper presented in iMed Meeting 2021, 2021.
  8. Pinho, Jacinta O.; da Silva, Inês V.; Amaral, JD; Rodrigues, C.M.P.; Casini, Angela; Graça Soveral; Gaspar, Maria Manuela. "Advancing colon cancer treatment using pH-sensitive nanoliposomes loading a copper complex". Paper presented in iMed Meeting 2021, 2021.
  9. da Silva, Inês V.; Silva, Andreia G.; Casini, Angela; Soveral, Graça. "Aquaporin-3 inhibition impairs melanoma cell migration". Paper presented in iMed Meeting 2021, 2021.
  10. da Silva, Inês V.; Santos, Ana C.; Matos, Andreia; Pereira da Silva ,Alda; Areias, M. J.; Soveral, Graça; Rebelo, Irene; Bicho, Manuel. "Aquaporin-3 and CYBA genetic polymorphisms may predict risk of developing hypertension.". Paper presented in Joint Meeting ESH-ISH ON-AIR, 2021.
  11. da Silva, Inês V.; Santos, Ana C.; Matos, Andreia; Pereira da Silva, Alda; Soveral, Graça; Rebelo, Irene; Bicho, Manuel. "Impacto do polimorfismo da AQP3 nos níveis de sVEGFR-1/sFlt-1 associados ao desenvolvimento de HTA após a gravidez". Paper presented in 15º Congresso Português de Hipertensão e Risco Cardiovascular Global, 2021.
  12. Matos, Andreia; Santos, Ana Carolina; da Silva, Inês V.; Pereira da Silva, Alda; Portelinha, Ana; Clara Bicho, Maria; José Areias, Maria; et al. "VEGFR/SFlt1 is associated to disruption of oxidative stress leading to endothelial dysfunction in preeclampsia". Paper presented in 22nd World Congress of International Society for the Study of Hypertension in Pregnancy, 2021.
  13. da Silva, Inês V.; Cardoso, C.; Martinez-Banaclocha, H.; Casini, A.; Pelegrin, P.; Soveral, G.. "Aquaporins in immune cells: contribution for inflammasome priming and activation.". Paper presented in The 44th FEBS Congress, 2019.
  14. da Silva, Inês V.; Cardoso, C.; Martinez-Banaclocha, H.; Casini, A.; Pelegrin, P.; Soveral, G.. "Aquaporin-3 is involved in NLRP3-inflammasome priming and activation.". Paper presented in 12th EBSA/10th ICBP-IUPAP Congress, 2019.
  15. da Silva, Inês V.; Santos, A. C.; Matos, A.; Pereira Da Silva, A.; Portelinha, A.; Areias, M. J.; Soveral, G.; Rebelo, I.; Bicho, M.. "Aquaporin-3 gene polymorphism may predict cardiovascular risk and hypertension.". Paper presented in The 2019 EuroISSHP Conference for the International Society of Hypertension in Pregnancy, 2019.
  16. da Silva, Inês V.; Méndez-Giménez, L.; Camões, S.P.; Frühbeck, G.; Rodríguez, A.; Miranda, J. P.; Soveral, G.. "Pancreatic AQP7 and AQP12: possible targets in obesity-induced inflammation.". Paper presented in 19th biennial meeting for the Society for Free Radical Research International, 2018.
  17. da Silva, Inês V.; Méndez-Giménez, L.; Miranda, J. P.; Frühbeck, G.; Rodríguez, A.; Soveral, G.. "Biophysical assessment of pancreatic aquaporins as water and glycerol channels and their implication in obesity-induced inflammation.". Paper presented in 1st Biophysics Party – Sociedade Portuguesa de Bioquímica, 2018.
  18. da Silva, Inês V.; Méndez-Giménez, L.; Miranda, J. P.; Fruhbeck, G.; Rodríguez, A.; Soveral, G.. "Biophysical Characterization of Pancreatic Aquaporins and their Involvement in Inflammation.". Paper presented in 10th iMed.ULisboa and 3rd i3du Meeting, 2018.
  19. Lemos, A. A.; Pinho, J. O.; Rodrigues, C.; da Silva, Inês V.; Gaspar, M. M.; Rivera, I.; Soveral, G.. "Aquaporin-3 expression in cancer cells as a novel biomarker for tumorigenesis.". Paper presented in 10th iMed.ULisboa and 3rd i3du Meeting, 2018.
  20. da Silva, Inês V.; Barroso, M.; Castro, R.; Soveral, G.. "Endothelial aquaglyceroporins: implications in disease.". Paper presented in Bioimaging Workshop, 2017.
  21. da Silva, Inês V.; Barroso, M.; Castro, R.; Soveral, G.. "Aquaporin activity in endothelia: a putative role in cardiovascular disease.". Paper presented in 9th Postgraduate iMed.ULisboa Students Meeting and 2st I3DU Meeting, 2017.
  22. da Silva, Inês V.; Méndez-Giménez, L.; Miranda, J. P.; Frühbeck, G.; Rodríguez, A.; Soveral, G.. "Unraveling aquaporin contribution to obesity-induced inflammation in the endocrine pancreas.". Paper presented in 1st Joint Meeting of the French-Spanish-Portuguese Biochemical and Molecular Biology Societies - Federal European Biophysical Society 3+ Congress, 2017.
  23. da Silva, Inês V.; Barroso, M.; Castro, R.; Soveral, G.. "Aquaglyceroporins expression in endothelial cells and implications in cardiovascular disease.". Paper presented in 5th International Iberian Biophysics Congress, 2016.
  24. da Silva, Inês V.; Barroso, M.; Castro, R.; Soveral, G.. "Endothelial aquaglyceroporins: new players in cardiovascular disease?". Paper presented in 8th Postgraduate iMed.ULisboa Students Meeting and 1st I3DU Meeting, 2016.
  25. Barbosa, P.; Rodrigues, A. M.; da Silva, Inês V.; Faria, J. M. S.; Sena, I.; Ribeiro, B.; Trindade, H.; et al. "Pine wilt disease: evaluation of nematode phytochemical control and nematode-host interaction". Paper presented in 67th International Symposium on Crop Protection, 2015.
  26. Brito, E.; Peres, J.; Gomes, E.; da Silva, Inês V.; Borges, C.; Pacheco, R.; Falé, P. L.; Ascensão, L.; Serralheiro, M. L.. "Antiacetylcholinesterase and antioxidant activities of several Plectranthus species". Paper presented in The XIX European Symposium of Organic Chemistry, 2015.
  27. da Silva, Inês V.; Barbosa, P.; Mota, M.; Ascensão, L.. "Responses of Pinus halepensis and P. sylvestris seedlings to the inoculation with the pinewood nematode Bursaphelenchus xylophilus: a comparative histopathological study". Paper presented in 4th Joint Congress "Microscopy at the Frontiers of Science", 2015.
  28. Tedesco, S.; da Silva, Inês V.; Santos, C.; Barrento, M. J.; Machado, H.; Figueiredo, P.; Gomes, F.. "Production of chestnut hybrids with resistance to ink disease". Paper presented in II Simpósio Nacional do Castanheiro, 2015.
  29. da Silva, Inês V.; Nogueira, T; Ascensão, L; Serralheiro, M. L.. "In vitro antioxidant and acetylcholinesterase inhibitory activities of two Hypericum species used in Portugal as herbal teas". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  30. Faria, J.; Sena, I.; Maleita, C.; da Silva, Inês V.; Ascensão, L.; Abrantes, I.; Bennett, R.; et al. "Characterization of structure, growth and production of volatiles of Solanum tuberosum hairy roots and Solanum tuberosum hairy roots/Meloidogyne chitwoodi in vitro co-cultures". Paper presented in International Congress from the Society for Medicinal Plant and Natural Product Research, 2014.
    10.1055/s-0034-1394962
  31. da Silva, Inês V.; Mota, L.; Barbosa, P.; Mota, M.; Ascensão, L.. "Histopathology of Bursaphelenchus xylophilus-infected seedlings of two pine species grown in Portugal". Paper presented in 1º Simpósio da Sociedade de Ciências Agrárias de Portugal – Novos Desafios na Protecção das Plantas – e 7º Congresso da Sociedade Portuguesa de Fitopatologia, 2014.
  32. da Silva, Inês V.; Nogueira, T.; Ascensão, L.; da Silva, I.V.; Vieira da Silva, I.. "New reports on secretory structures of vegetative and floral organs of Hypericum elodes (Hypericaceae)". Paper presented in XLVII Congress of the Portuguese Society for Microscopy, 2013.
    10.1017/s143192761401397x
  33. da Silva, Inês V.; Bernardes da Silva, A.; Alcântara, A.; Marques da Silva, J.; Arrabaça, J. D.; Matos, A. R.. "Effects of progressive drought in Arabidopsis plants overexpressing or silenced for the patatin-like gene pPLAlla.". Paper presented in 24th International Conference on Arabidopsis Research, 2013.
  34. da Silva, Inês V.; Nogueira, T.; Ascensão, L.. "Secretory structures on the flower of the Hypericum pubescens and H. tomentosum.". Paper presented in Microscopy at the Frontiers of Science, 2013.
  35. da Silva, Inês V.; Bernardes da Silva, A.; Alcântara, A.; Marques da Silva, J.; Arrabaça, J. D.; Matos, A. R.. "Contribution of the patatin-like protein pPLAIIa to progressive drought stress using silenced and overexpressing Arabidopsis plants.". Paper presented in 20th International Symposium of Plant Lipids, 2012.
Journal article
  1. da Silva, Inês V.; Pimpão, Catarina; Paccetti-Alves, Inês; Thomas, Sophie R.; Barateiro, Andreia; Casini, Angela; Soveral, Graça. "Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration". The Journal of Physiology (2024): http://dx.doi.org/10.1113/jp284155.
    Published • 10.1113/jp284155
  2. Paula A. Lopes; Elisabete Fonseca; Inês V. da Silva; Emanuel Vigia; Jorge Paulino; Graça Soveral. "Aquaporins Transcripts with Potential Prognostic Value in Pancreatic Cancer". Genes (2023): https://doi.org/10.3390/genes14091694.
    10.3390/genes14091694
  3. Silva, Inês V. da; Coelho, Diogo; Prates, José António Mestre; Soveral, Graça; Lopes, Paula A.. "Tissue-Specific Variation in Aquaporins and Cytokines Transcriptional Profiles in Piglets being LPS Challenged". Frontiers in Bioscience-Landmark 28 6 (2023): 126. http://dx.doi.org/10.31083/j.fbl2806126.
    10.31083/j.fbl2806126
  4. Monika Mlinaric; Ivan Lucic; Lidija Milkovic; Inês V. da Silva; Ivana Tartaro Bujak; Vesna Musani; Graça Soveral; Ana Cipak Gašparovic. "AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24098133.
    10.3390/ijms24098133
  5. Gema Frühbeck; Leire Méndez-Giménez; Sara Becerril; Beatriz Ramírez; Ana Wenting Hernández-Pardos; Javier A. Cienfuegos; Víctor Valentí; et al. "Increased Aquaporin-7 Expression Is Associated with Changes in Rat Brown Adipose Tissue Whitening in Obesity: Impact of Cold Exposure and Bariatric Surgery". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043412.
    10.3390/ijms24043412
  6. Inês V. da Silva; Sabino Garra; Giuseppe Calamita; Graça Soveral. "The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker". Biomolecules 12 7 (2022): 897-897. https://doi.org/10.3390/biom12070897.
    10.3390/biom12070897
  7. Inês V. da Silva; Sean Gullette; Cristina Florindo; Neil K. Huang; Thomas Neuberger; A. Catharine Ross; Graça Soveral; Rita Castro. "The Effect of Nutritional Ketosis on Aquaporin Expression in Apolipoprotein E-Deficient Mice: Potential Implications for Energy Homeostasis". Biomedicines 10 5 (2022): 1159-1159. https://doi.org/10.3390/biomedicines10051159.
    10.3390/biomedicines10051159
  8. Patrícia M. Silva; Inês V. da Silva; Maria J. Sarmento; Ítala C. Silva; Filomena A. Carvalho; Graça Soveral; Nuno C. Santos. "Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties". Cells 11 8 (2022): 1308-1308. https://doi.org/10.3390/cells11081308.
    10.3390/cells11081308
  9. Pimpão, Catarina; Wragg, Darren; da Silva, Inês V.; Casini, Angela; Soveral, Graça. "Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.845237.
    Published • 10.3389/fmolb.2022.845237
  10. Jorge M. S. Faria; Inês V. da Silva. "Anti-Nematodal Essential Oils with Activity against Anisakis". Medical Sciences Forum (2021): https://doi.org/10.3390/ECMS2021-10827.
    10.3390/ECMS2021-10827
  11. da Silva, Inês V.; Silva, Andreia G.; Pimpão, Catarina; Soveral, Graça. Corresponding author: da Silva, Inês V.. "Skin aquaporins as druggable targets: Promoting health by addressing the disease". Biochimie (2021): http://dx.doi.org/10.1016/j.biochi.2021.05.019.
    Published • 10.1016/j.biochi.2021.05.019
  12. da Silva, Inês V.; Soveral, Graça. "Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development". International Journal of Molecular Sciences 22 4 (2021): 1845. http://dx.doi.org/10.3390/ijms22041845.
    Published • 10.3390/ijms22041845
  13. da Silva, Inês V.; Courtney A. Whalen; Floyd Mattie; Cristina Florindo; Neil K. Huang; Sandra G. Heil; Thomas Neuberger; et al. "An Atherogenic Diet Disturbs Aquaporin 5 Expression in Liver and Adipocyte Tissues of Apolipoprotein E-Deficient Mice: New Insights into an Old Model of Experimental Atherosclerosis". Biomedicines (2021): https://www.mdpi.com/2227-9059/9/2/150.
    10.3390/biomedicines9020150
  14. da Silva, Inês V.; Santos, Ana C.; Matos, Andreia; Pereira da Silva, Alda; Soveral, Graça; Rebelo, Irene; Bicho, Manuel. Corresponding author: da Silva, Inês V.. "Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women". Pregnancy Hypertension (2021): http://dx.doi.org/10.1016/j.preghy.2021.02.008.
    Published • 10.1016/j.preghy.2021.02.008
  15. da Silva, Inês V.; Bárbara P. Soares; Catarina Pimpão; Rui M. A. Pinto; Teresa Costa; João P. B. Freire; Etienne Corrent; et al. "Glutamine and cystine-enriched diets modulate aquaporins gene expression in the small intestine of piglets". PLOS ONE (2021): https://doi.org/10.1371/journal.pone.0245739.
    10.1371/journal.pone.0245739
  16. Pinho, Jacinta O.; da Silva, Inês V.; Amaral, Joana D.; Rodrigues, Cecília M. P.; Casini, Angela; Soveral, Graça; Gaspar, Maria Manuela; et al. "Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management". International Journal of Pharmaceutics (2021): https://doi.org/10.1016/j.ijpharm.2021.120463.
    In press • 10.1016/j.ijpharm.2021.120463
  17. da Silva, Inês V.; Cardoso, Carlos; Martinez-Banaclocha, Helios; Casini, Angela; Pelegrin, Pablo; Soveral, Graça. "Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response.". Cellular and molecular life sciences : CMLS (2020): https://doi.org/10.1007/s00018-020-03708-3.
    10.1007/s00018-020-03708-3
  18. da Silva, Inês V.; Carlos Cardoso; Leire Méndez-Giménez; Sérgio Povoas Camoes; Gema Frühbeck; Amaia Rodríguez; Joana Paiva Miranda; Soveral, Graça. "Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells". Archives of Biochemistry and Biophysics 691 (2020): 108481-108481. https://doi.org/10.1016/j.abb.2020.108481.
    10.1016/j.abb.2020.108481
  19. Patrícia Fernandes; Sara Tedesco; da Silva, Inês V.; Carmen Santos; Helena Machado; Rita Lourenço Costa. "A New Clonal Propagation Protocol Develops Quality Root Systems in Chestnut". Forests 11 8 (2020): 826-826. https://doi.org/10.3390/f11080826.
    10.3390/f11080826
  20. Pimpão, Catarina; da Silva, Inês V.; Andreia F. Mósca; Jacinta Pinho; Gaspar MM; Nadiia Gumerova; Annette Rompel; M. Aureliano; Soveral, Graça. "The Aquaporin-3-Inhibiting Potential of Polyoxotungstates". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/7/2467.
    10.3390/ijms21072467
  21. Da Silva, I.V.; Díaz-Sáez, F.; Zorzano, A.; Gumà, A.; Camps, M.; Soveral, G.. "Aquaglyceroporins are differentially expressed in beige and white adipocytes". International Journal of Molecular Sciences 21 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078176028&partnerID=MN8TOARS.
    10.3390/ijms21020610
  22. Rodrigues, C.; Pimpão, C.; Mósca, A.F.; Coxixo, A.S.; Lopes, D.; da Silva, Inês V.; Pedersen, P.A.; Antunes, F.; Soveral, G.. "Human aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration". Cancers 11 7 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068723172&partnerID=MN8TOARS.
    10.3390/cancers11070932
  23. Lopes, P.A.; Martins, R.; da Silva, Inês V.; Madeira, M.S.; Prates, J.A.M.; Soveral, G.. "Modulation of aquaporin gene expression by n-3 long-chain PUFA lipid structures in white and brown adipose tissue from hamsters". British Journal of Nutrition 120 10 (2018): 1098-1106. http://dx.doi.org/10.1017/s0007114518002519.
    10.1017/s0007114518002519
  24. Gomes, A.; da Silva, I.V.; Rodrigues, C.M.; Castro, R.E.; Soveral, G.. "The emerging role of microRNAs in aquaporin regulation". Frontiers in Chemistry 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049204790&partnerID=MN8TOARS.
    10.3389/fchem.2018.00238
  25. da Silva, I.V.; Rodrigues, J.S.; Rebelo, I.; Miranda, J.P.G.; Soveral, G.. "Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins". Cellular and Molecular Life Sciences 75 11 (2018): 1973-1988. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042220585&partnerID=MN8TOARS.
    10.1007/s00018-018-2781-4
  26. Da Silva, I.V.; Barroso, M.; Moura, T.; Castro, R.; Soveral, G.. "Endothelial aquaporins and hypomethylation: Potential implications for atherosclerosis and cardiovascular disease". International Journal of Molecular Sciences 19 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041828153&partnerID=MN8TOARS.
    10.3390/ijms19010130
  27. Méndez-Giménez, L.; Ezquerro, S.; da Silva, I.V.; Soveral, G.; Frühbeck, G.; Rodríguez, A.. "Pancreatic aquaporin-7: A novel target for anti-diabetic drugs?". Frontiers in Chemistry 6 APR (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047499607&partnerID=MN8TOARS.
    10.3389/fchem.2018.00099
  28. Méndez-Giménez, L.; Becerril, S.; Camões, S.P.; Da Silva, I.V.; Rodrigues, C.; Moncada, R.; Valentí, V.; et al. "Role of aquaporin-7 in ghrelin-and GLP-1-induced improvement of pancreatic ß-cell function after sleeve gastrectomy in obese rats". International Journal of Obesity 41 9 (2017): 1394-1402. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028885406&partnerID=MN8TOARS.
    10.1038/ijo.2017.135
  29. Faria, J.M.S.; Sena, I.; Vieira da Silva, I.; Ribeiro, B.; Barbosa, P.; Ascensão, L.; Bennett, R.N.; Mota, M.; Figueiredo, A.C.. "In vitro co-cultures of Pinus pinaster with Bursaphelenchus xylophilus: a biotechnological approach to study pine wilt disease". Planta 241 6 (2015): 1325-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939979401&partnerID=MN8TOARS.
    10.1007/s00425-015-2257-9
  30. Faria, J; Sena, I; Maleita, CM; da Silva, Inês V.; Ascensão, L; Abrantes, I; Bennett, RN; Mota, M; Cristina Figueiredo, A. "Characterization of structure, growth and production of volatiles of Solanum tuberosum hairy roots and Solanum tuberosum hairy roots/Meloidogyne chitwoodi in vitro co-cultures". Planta Medica 80 16 (2014): http://dx.doi.org/10.1055/s-0034-1394962.
    10.1055/s-0034-1394962
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/02/11 Implications of Aquaporin-3 and Aquaporin-5 in cell migration and tumor signaling pathways in pancreatic cancer 52ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto)
2021/10/16 Downregulation of aquaporins gene expression by glutamine or cystine-enriched diets in the small intestine of piglets XXI SPB - National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Évora, Portugal)
2021/10/15 Peroxiporins and pancreatic cancer: new roles for aquaporin-3 and aquaporin-5 in tumor biology XXI SPB - National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Évora, Portugal)
2021/02/18 Aquaporin-3 is involved in inflammasome activation contributing to the settings of inflammatory response in THP-1 cells 51ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2021/02/17 Aquaporin inhibition with gold compounds impairs melanoma cells migration 51ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2020 Biomarcadores associados ao risco cardiovascular e a sua modulação por variantes genéticas das aquaporinas, na psoríase. 14.º Congresso Português de Hipertensão e Risco Cardiovascular Global
(Vilamoura, Portugal)
2019 Involvement of aquaporins in inflammasome priming and activation COST Action BM1406 Meeting
University of Graz (Graz, Austria)
2019 Involvement of aquaporin-3 in inflammasome priming and activation in THP-1 macrophages-like cells 11th iMed.ULisboa and 4th i3du Meeting
Institute for Research in Medicines (Lisboa, Portugal)
2018 Aquaporins in Endocrine Pancreas: possible targets in obesity-induced inflammation XLVIII SPFMeeting – Sociedade Portuguesa de Farmacologia
Faculdade de Medicina Universidade de Lisboa (Lisboa, Portugal)
2018 Aquaporins and hypomethylation in endothelia: implications in cardiovascular disease. The 43rd FEBS Congress
(Prague, Czech Republic)
2017 Evaluate aquaporin function in adherent cells by fluorescence microscopy
2015 Characterization of the pinewood nematode, Bursaphelenchus xylophilus-Pinus system in Portugal: phytochemical, histopathological, molecular and biotechnological approaches. 47th Annual Meeting
Organization of Nematologists of the Tropical America (Varadero, Cuba)
2015 Characterization of the Pinewood Nematode with Pinus System in Portugal: Phytochemical, Histopathological, Molecular and Biotechnological Approaches 47th Annual Meeting of the Organization of Nematologists of Tropical America
Organization of Nematologists of Tropical America (Varadero, Cuba)
2013 Contribution of pPLAIIa to drought tolerance using genetically modified Arabidopsis plants: Fatty acids, lipid peroxidation products and membrane permeability. Oxidative stress and cell death in plants: mechanisms and implications Plant Simposium
Society of Experimental Biology (Florença, Italy)
2012/09/18 Photosynthetic response of Arabidopsis plants overexpressing (OE) or antisense (AS) for the patatin-like gene AtpPLAIIa to water deficit. XI Simposio Hispano-Portugués de Relaciones Hídricas en las Plantas
(Sevilha, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - Current Modulation of AQP-induced inflammatory response in immune cells by miRNAs
Supervisor
 Biochemistry and Biomedicine (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11/01 - 2021/12/28 Involvement of aquaporin-3 in melanoma
Supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/11/05 - 2020/11/06 COST Action CA 17104 Training school: 3D cell models – a powerful tool to study MDR” (StrataCell)
Workshop
 3D cell models – a powerful tool to study MDR” (StrataCell)
Lithuanian University of Health Sciences, Lithuania
2019/02/11 - 2019/02/14 COST Action BM1406: Ion Channels and Immune Disease
Meeting
 Ion Channels and Immune Disease
Technische Universität Graz, Austria
2018/06/17 - 2018/06/21 Summer School SPYWATCH Physiology and Biophysics of Water and Ion Channels
Workshop
 Physiology and Biophysics of Water and Ion Channels - SPYWATCH
Università degli Studi di Bari Aldo Moro, Italy
2018/03/08 - 2018/03/09 COST Action BM1406: Ion Channels and Immune Disease
Meeting
 Ion Channels and Immune Disease
Dublin City University Faculty of Science and Health, Ireland
2017/06/19 - 2017/06/23 Advanced Methods in Microscopy Module E Summer Course
Workshop
 Advanced Methods in Microscopy Module E Summer Course
Københavns Universitet - Frederiksberg Campus, Denmark
2016/03/09 - 2016/03/11 COST Action BM1406: Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches (IONCHAN-IMMUNRESPON)
Meeting
 Ion Channels and Immune Response toward a global understanding of immune cell physiology and for new therapeutic approaches (IONCHAN-IMMUNRESPON)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/11/12 - 2015/11/14 5th Workshop in Structure and Function of Ion Channels and Transporters (SFICT)
Workshop
 Structure and Function of Ion Channels and Transporters
Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/28 Involvement of aquaporin-3 in melanoma
Supervisor
 Andreia Gonçalves Silva (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/02/26 Aquaporins involvement in hepatic ischemia reperfusion injury, Master in Biopharmaceutical Sciences
(Thesis) Main arguer
 Jéssica Fernandes (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2021/01 - Current Portuguese Society of Pharmacology Member
2021/01 - Current Portuguese Young Biophysicists Member of the organizing comittee of the annual biophysics students meeting - Biophysics Festival
2014 - Current Portuguese Biochemical Society Member

Committee member

Activity description
Role 		Institution / Organization
2016/01/01 - 2017/07/31 Representative of the PhD Student Commission at Research Institute for Medicines (iMed.ULisboa)
Member

Conference scientific committee

Conference name Conference host
2021/06 - Current iMed.ULisboa Meeting 2021 IpSC members

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02 - Current Biochemistry I Ciências Farmacêuticas (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09 - Current Escrita e Comunicação Científica Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09 - Current Membrane Channels and Transporters Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2021/09 - Current Peroxiporins involvement in oxidative stress and their potential for drug targeting Joana Pimenta
2021/09 - Current Aquaporins as drug-targets for pancreatic cancer and biomarkers in prognosis Elisabete Fonseca
2021/01/01 - Current PhD student - "Cell-based platform to investigate aquaporins as targets for cancer drug discovery" Catarina Gonçalves Pimpão
2018 - Current PhD student - "AQP3 and AQP5 involvement in pancreatic cancer" Patrícia M. Silva
2023/09/01 - 2024/02/29 Aquaporins involvement in sepsis and artificial intelligence Nicola Zagaria
2021/11/04 - 2021/12/04 International PhD student (Bari, Italy) - "Aquaporins from white blood cells in the inflammatory response involving the NLRP3 inflammasome" Sabino Garra
2019/11/01 - 2021/02/26 Aquaporins involvement in hepatic ischemia reperfusion injury Jéssica Fernandes
2019/11/01 - 2020/12/31 Glutamine and cystine-enriched diets downregulate aquaporins gene expression in the small intestine of piglets Bárbara Soares
2017/09/01 - 2018/12/31 Modulation of aquaporin 7 in adipocytes by miR-296 André Gomes
2016/11/01 - 2018/03/31 Modulation of aquaporins gene expression by n-3 polyunsaturated fatty acids (PUFA) lipid structures in white and brown adipose tissue from hamsters Rute Martins
Distinctions

Award

2021 Best oral communication in the “Molecular Mechanisms of Disease” session
Sociedade Portuguesa de Bioquímica, Portugal
2015 Scientific Poster Prize

Title

2019 PhD with distinction and honors by unanimity