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I am a researcher of the Tumour and Microenvironment Interactions group, leading the Iron Metabolism and Oncobiology research line, at the Institute for Research & Innovation in Health (i3S). My scientific career started in 2004, at the Malaria immunology-CNRS-IGC European Lab where I concluded my Biology BSc thesis on T cell proliferation and co-authored my 1st publication on the role of Treg cells in cerebral malaria. Then, in 2006, I moved to the Clinical Immunology and Rheumatology Lab at the AMC, acquiring expertise in pre-clinical mouse models and the FELASA C certificate - Utrecht University. In 2007, I joined the Institute for Molecular and Cell Biology (University of Porto), where I obtained my PhD degree in Biomedical Sciences with the thesis on Iron Metabolism at the host-pathogen interface, publishing 3 ISI papers and 1 open-access software for image analysis (CellNote), in collaboration with the Telecommunication Institute. I was awarded a Short-term Mission grant by DNDi COST Action CM0801 and went to the Microbiology Parasitology and Hygiene Lab - Antwerp University, as a CellNote ambassador, exchanging knowledge in drug screening techniques. As a Post-Doc, I actively participated in 2 FCT-funded projects on Iron Metabolism and Drug Discovery, published 3 papers, including an automated image analysis protocol, and increased my collaborative network on Iron Biology (F. Cannone-Hergaux, INSERM; M. Muckenthaler, KiTZ; E. Nemeth, UCLA). I have also developed a project (PTDC/QEQ-MED/7097/2014) focused on the repurposing of chemotherapeutic compounds for leishmaniasis treatment, published 5 papers in Q1 journals, and extended networking with Drug Discovery experts J. Barlow - Imperial College London, and Rui Moreira and A. Ressureição - iMEd.UL. In 2018, I obtained my Clinical Research Monitor certificate from CTI, paving the way for a translational research career. In 2019, I moved to the Oncology field, integrating the TMI group at i3S as a responsible for conducting a collaborative project (PTDC/BIA-CEL/31743/2017) led by Rui Travasso (Centro de Física, U. Coimbra), publishing 1 first-author and 2 co-author papers, contributing with 2 presentations (EMBO workshop on Vascular malformations and EACR Goodbye Flat Biology meeting), and participating in the COST Action EuroCellNet CA15214. Meanwhile, I started a new research line bridging Iron Metabolism and Oncobiology, enabling the graduation of 3 MSc students with theses on the impact of radiotherapy on macrophage iron metabolism, the crosstalk between adipocytes and macrophages in renal carcinoma, and in radiotherapy effects on rectal cancer secretome. In 2021, through competitive calls, I was awarded an FCT project (EXPL/BIA-CEL/1225/2021) and 1 Nanostring Grant as PI to study the effect of radiotherapy in rectal cancer immune profile and iron metabolism. Within the scope of these projects, I established collaborations with IPO-Porto and Olivier de Wever Lab at CRIG and recruited 2 PhD FCT-funded Student in a co-tutelage doctorate between Porto and Ghent Universities. I also contribute to higher education and to public awareness, as an invited professor in the Portuguese Red Cross Nursing College and lecturer of the GABBA PhD course and by engaging in Ciência Viva activities and i3S educational programs, respectively. I have experience as a jury of academic panels and PhD/MSc theses scientific committees. I am a PLoS One, DDTR and CCHTS reviewer, EACR ambassador, ASPIC, SPI, ESTro and BioIron society member, and a mentor of the Global Talent Mentoring. Until May 2023, I published 17 papers in ISI journals, with >70 natl. and internl. co-authors, 1 book chapter, 16 oral presentations, 39 poster communications at world-class meetings, participated in 3 COST actions, supervised 9 students (1PhD, 5MSc, 3BSc), tutored 14 students (PhD, MSc), and 5 received awards.
Identification

Personal identification

Full name
Tânia Cruz
Date of birth
1981/07/02
Gender
Female

Citation names

  • Cruz, Tânia
  • Cruz, T. B.

Author identifiers

Ciência ID
8B10-F75C-E2E2
ORCID iD
0000-0001-7051-040X

Email addresses

  • tcruz@i3s.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6070 (Professional)

Addresses

  • I3S. Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Hematology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Health Sciences
  • Exact Sciences - Computer and Information Sciences - Computer Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2023/09/09 - 2023/09/13
Concluded
Basic Clinical Radiobiology (Outros)
European SocieTy for Radiotherapy and Oncology, Belgium
2023/04 - 2023/04
Concluded
Data Protection course and the GDPR 2.0 (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/29 - 2021/10/11
Concluded
Research Project Management Course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - 2019
Concluded
Course Atomic Force Microscopy applied to Life Sciences (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2018
Concluded
Clinical research associate (Outros)
CTI Clinical Trial and Consulting Services Lisbon, Portugal
Approved
2012 - 2012
Concluded
How to teach science (Outros)
Major in Workshop
Science4You, Portugal
2007 - 2012
Concluded
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Iron metabolism in the context of a Leishmania infantum infection" (THESIS/DISSERTATION)
Approved
2006 - 2006
Concluded
FELASA category C (Postgraduate Certificate)
Universitair Medisch Centrum Utrecht Hersencentrum, Netherlands
Approved
2006 - 2006
Concluded
Immunology Advanced Course (Outros)
Universiteit van Amsterdam, Netherlands
2005 - 2005
Concluded
Flow cytometry hands-on course. (Curso de Especialização Tecnológica)
Instituto Gulbenkian de Ciência, Portugal
1999 - 2004
Concluded
Biologia (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Study of protective mechanisms against cerebral malaria using animal models" (THESIS/DISSERTATION)
16 (ou of 20)
Affiliation

Science

Category
Host institution
Employer
2021 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - 2021 Contracted Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012 - 2018 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2010 Visiting Researcher (Research) Universiteit Antwerpen, Belgium
Universiteit Antwerpen, Belgium
2006 - 2007 Visiting Researcher (Research) AMC, Netherlands
Universiteit van Amsterdam, Netherlands
(...)
2004 - 2005 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2003 - 2004 Research Trainee (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2018 - 2019 Visiting Teacher (Polytechnic Teacher) Portuguese Red Cross Nursing College , Portugal
Portuguese Red Cross Nursing College , Portugal
Projects

Grant

Designation Funders
2022/04/01 - Current New 2D nanomaterials for cancer phototherapy and immunotherapy
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2021 - Current Bridging iRon metabolism and immunE cells at the irrAdiateD tumOUr microenvironmenT to tailor improved therapeutic approaches
Exclusive Grant for Gene Expression Panels
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
NanoString Technologies Inc Europe
Ongoing
2023/01 - 2023/12/31 Radiocommunication : unraveling the role of extracellular vesicles in rectal cancer radioresistance
NRM-LPCC Rubina Barros Grant 2022
Principal investigator
Liga Portuguesa Contra o Cancro, Portugal
Liga Portuguesa Contra o Cancro
Ongoing
2023 - 2023/12/31 Exploring the role of the checkpoint CD24 in meduloblastoma biology and therapies
--
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação Rui Osório de Castro - Algebra
Ongoing
2016 - 2018 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical
PTDC/QEQ-MED/7097/2014
Post-doc Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2016 Towards new formulas for Leishmaniasis therapy
NORTE-01-0145-FEDER-000012
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2016 Host-Pathogen Interactions
ON2201310-HPI-V
Research Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2012 Acquisition of iron in Leishmania infantum - which are the players and what is their relevance for pathogenesis?
PTDC/CVT/100090/2008
PhD Student Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2007 Role of Rap1 in Rheumatoid Arthrites (Clinical Immunology and Rheumatology Lab)
.
Researcher
Amsterdam UMC Locatie AMC Afdeling Immunologie Rheumatologie en infectieziekten bij kinderen, Netherlands
Concluded

Contract

Designation Funders
2023/03/12 - 2024/09/11 Novas formulações farmacêuticas para fototerapia do cancro retal
2022.04494.PTDC
Universidade do Porto Faculdade de Engenharia, Portugal

The University of Texas at Austin, United States

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01 - 2024/01/15 Bridging iRon metabolism and immunE cells at the irrAdiateD tumOUr microenvironmenT to identify novel therapeutic targets in rectal cancer
EXPL/BIA-CEL/1225/2021
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/10/01 - 2023/11/30 Dissect the tumor microenvironment to battle cancer radioressistance and immune escape
PTDC/MED-OUT/4165/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022/04/01 - 2023/06/30 Novos Nanomateriais 2D para fototerapia e imunoterapia do cancro
UTAP-EXPL/NPN/0044/2021
The University of Texas at Austin, United States

Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/09 - 2022/01 AbSCisSA | Disclosing hemAtopoietic Stem Cell SelfrenewAl at the developing fetal liver intersection
PTDC/MED-OUT/32656/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2021 Modeling Angiogenesis in Type 2 Diabetes Mellitus - integrating experimental and theoretical approaches
PTDC/BIA-CEL/31743/2017
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade de Coimbra Centro de Física, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2006 T cells impact in experimental Plasmodium infection (Malaria immunology-CNRS-IGC European Laboratory)
.
Scientific Initiation Fellow
Instituto Gulbenkian de Ciência, Portugal
Concluded

Other

Designation Funders
2021 - Current Tumour and Microenvironment Interactions group LinkedIn page
.
Social Media Manager
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2020/04 - 2020/08 COVID19 TASK FORCE | Team Leader Volunteer
..
Team Leader Volunteer
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Catarina Moreira-Barbosa, Andreia Matos, Rui Fernandes, Miguel Mendes-Ferreira, Rafaela Rodrigues; Cruz, Tânia; Ângela Margarida Costa, Ana Patrícia Cardoso, Carmen Ghilardi, Maria José Oliveira, Ricardo Ribeiro. "The role of fatty acids metabolism on cancer progression and therapeutics development". In Bioactive Lipids. Elsevier, 2022.
    Published
Conference poster
  1. Coelho, Diogo; Cruz, Tânia; Ribeiro, Carlos J A; Silva, Eduarda M. P.; Maria José Oliveira; Sarmento, Bruno. "A lipophilic 5-Fluorouracil prodrug to effectively encapsulate 5-FU and treat rectal cancer". Paper presented in PhD day, 5th Edition, Gandra, 2023.
  2. Cruz, Tânia; Verónica Fernandes; Luísa Pereira; Angela M Costa. "SLC11A2 (DMT1) expression is downregulated by macrophagic infiltration at right colon tumors". 2023.
  3. Coelho, Diogo; Cruz, Tânia; Silva, Eduarda M. P.; Maria José Oliveira; Sarmento, Bruno. "A novel biofunctional nanoparticle-based system for immuno-chemotherapy delivery in rectal cancer". Paper presented in Brilliant PhDs, brighter future: Shaping Science together! - i3S PhD Day, 6th Edition, 2023.
  4. Diogo Estêvão, Miguel da Cruz-Ribeiro, Ana C. Silva, Carmén Jerónimo, Olga Sousa, Olivier de Wever, Maria J. Oliveira; Cruz, Tânia. "Dissecting the radiotherapy-mediated changes in rectal cancer immune profile". Paper presented in XLVIII SPI Annual Meeting 2023, 2023.
  5. da Cruz-Ribeiro, Miguel; Estêvão, Diogo; Sousa, Olga; De Wever, Olivier; Maria José Oliveira; Cruz, Tânia. Corresponding author: da Cruz-Ribeiro, Miguel. ""Radiocomunicação": Desvendar o papel das vesículas extracelulares em radiorresistência". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia, 2022.
  6. da Cruz-Ribeiro M; Estêvão D.; Sousa O.; De Wever O.; Oliveira MJ.;; Cruz, Tânia. "Radiotherapy effect on rectal cancer secretome". Paper presented in 4º ENJIO - Encontro Nacional de Jovens Investigadores em Oncologia, 2022.
  7. Estêvão D.; da Cruz-Ribeiro M; Sousa O.; De Wever O.; Oliveira MJ; Cruz, Tânia. "Goodbye flat biology: Development of a 3D rectal cancer spheroid.". Paper presented in 4th Symposium on Immunomodulation in Cancer & Regeneration, 2022.
  8. Silveira, M.J.; Cruz, Tânia; Oliveira, M.J; Sarmento, Bruno. "Unraveling the therapeutic potential of CEA-targeted nanoparticles in colorectal cancer cells and to modulate its tumor microenvironment". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022.
  9. F Pereira; Cruz, Tânia; CA Reis, MJ Oliveira, A Preto. "Dissecting the interplay KRAS/Galectin-3/Tumor-associated macrophages in colorectal carcinogenesis". Paper presented in European Association for Cancer Research (EACR), 2022.
  10. Marques-Magalhães Â, Pinto ML, ; Cruz, Tânia; Caldeira J, Osório H, Canão PA, Rios E, Carneiro F, Cardoso AP, Gonçalves R, Oliveira MJ.. "Unveil the biochemical and biomechanical properties of colorectal cancer patients-derived tissues from different colon locations". Paper presented in The Structural Microenvironment: Breaking down the walls of cancer (EACR), 2022.
  11. Marques-Magalhães Â, Pinto M.L, ; Cruz, Tânia; Caldeira J, Osório H, Canão P, Rios E, Carneiro F, Cardoso AP, Gonçalves R, Oliveira M.J.. "Dissecting the extracellular matrix signature of right- and left-sided colon cancer using patients-derived scaffolds". Paper presented in he Extracellular Matrix Pharmacology Congress, 2022.
  12. Marques-Magalhães Â, Pinto M.L; Cruz, Tânia; Caldeira J, Osório H, Canão P, Rios E, Carneiro F, Cardoso AP, Gonçalves R, Oliveira M.J.. "Unveil the extracellular matrix signature from colorectal cancer patients-derived tissues: the side matters?". Paper presented in Matrix Biology Europe, 2022.
  13. Estêvão D.; Ribeiro M. ; Sousa O. De Wever O. Oliveira MJ.; Cruz, Tânia. "Characterization of a 3D rectal cancer model". Paper presented in 5th ASPIC International Congress, 2022.
  14. Estêvão D.; Ribeiro M. ; Sousa O. De Wever O. Oliveira MJ.; Cruz, Tânia. "3D rectal cancer spheroid: a new tool for uncovering novel therapeutic targets". Paper presented in VIB Conference: Recent Insights in Immuno-Oncology, 2022.
  15. Estêvão D.; Ribeiro M. ; Sousa O. De Wever O. Oliveira MJ.; Cruz, Tânia. "3D rectal cancer spheroid: a new tool for uncovering novel therapeutic targets". Paper presented in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022.
  16. Estêvão D.; Ribeiro M. ; Sousa O. De Wever O. Oliveira MJ.; Cruz, Tânia. "Unveilling radiotherapy-mediated changes in rectal cancer iron metabolism and immune profile". Paper presented in 6thEDITION. The International Conference on Immunotherapy Radiotherapy Combinations, 2022.
  17. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Dissecting the biochemical and biomechanical properties of colorectal cancer extracellular matrix". Paper presented in II ASPIC-ASEICA International meeting ¿ Current trends in precision medicine in cancer, 2021.
  18. Cruz, Tânia; Marcos Gouveia, Maria J. Oliveira, Rui Travasso. "Biomechanical properties of obese and diabetic extracellular matrices impact on blood vessel formation". Paper presented in EACR Goodbye Flat Biology: Next Generation Cancer Models, 2021.
  19. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Dissecting the properties of colorectal cancer patients-derived extracellular matrix". Paper presented in Goodbye Flat Biology: Next generation cancer models, 2021.
  20. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Cancro colorrectal: propriedades bioquímicas e biomecânicas da matriz extracelular de pacientes". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2021.
  21. Mendes-Ferreira, Miguel; Matos, Andreia; Cruz, Tânia; Fernandes, Rui; Oliveira, Maria J.; Ribeiro, Ricardo. "The Peritumoural Adipose Tissue And Clear Cell Renal Cell Carcinoma Interface: Insights on the Obesity Paradox". Paper presented in EMBO PRACTICAL COURSE | SINGLE CELL GENOMICS: GET STARTED (Braga, Portugal), 2021.
  22. Rodrigues R, Fernandes, R., Barbosa, C., Pereira, F., Matos, A., Mendes, M., Oliveira, MJ; Cruz, Tânia. "Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma | The Triad Macrophage-Cancer Cell-Adipocyte". Paper presented in IJUP 2021, 2021.
  23. Ângela Marques-Magalhães, Marta Laranjeiro Pinto, Ana Borges, Flávia Castro,; Cruz, Tânia; Joana Caldeira, Hugo Osório, Pedro Canão, Elisabete Rios, Fátima Carneiro, Ana Patrícia Cardoso, Raquel Gonçalves,; Maria José Oliveira. "Colorectal cancer extracellular matrix: biochemical cues for disease progression". Paper presented in EACR Conference – Defense is the Best Attack: Immuno-Oncology Breakthroughs, 2021.
  24. Miguel Mendes-Ferreira; José Preza Fernandes; Andreia Matos; Rafaela Rodrigues; Rui Fernandes;; Cruz, Tânia; Miguel Ramos; Avelino Fraga; Maria José Oliveira; Alexandra Gouveia; Ricardo Ribeiro. "The peritumoural adipose tissue and clear cell renal cell carcinoma interface". Paper presented in Single cell genomics - EMBO practical course, 2021.
  25. Rodrigues R.; Fernandes, R. ; Moreira-Barbosa, C. ; Pereira, F. ; Matos, A.; Mendes, M.; Oliveira, MJ; Ribeiro, R. ; Cruz, Tânia. "Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma - The Triad: Macrophage-Cancer Cell-Adipocyte". Paper presented in 3º Encontro nacional de jovens investigadores em oncologia - ENJIO, 2021.
  26. Maria José Silveira; Catarina Moreira-Barbosa; Cláudia Martins; Cruz, Tânia; Maria José Oliveira; Bruno Sarmento. "CEA-targeted Nanoparticles as novel Chemotherapy for Colorectal Cancer treatment". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  27. Estevão, Diogo; Ribeiro, Miguel ; Sousa, Olga; Oliveira, Maria José; De Wever, Olivier; Cruz, T.. "Decoding novel therapeutic targets against rectal cancer: iron metabolism and immune microenvironment". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  28. Estevão, Diogo; Ribeiro, Miguel ; Sousa, Olga; Oliveira, Maria José; De Wever, Olivier; Cruz, T. "Decoding novel therapeutic targets against rectal cancer: iron metabolism and immune microenvironment". Paper presented in PhDay, i3S-Institute for Research & Innovation in Health., 2021.
  29. Rodrigues R.; Fernandes, R. ; Moreira-Barbosa, C. ; Pereira, F. ; Matos, A.; Mendes, M.; Oliveira, MJ; Ribeiro, R. ; Cruz, T.. "Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma | The Triad: Macrophage-Cancer Cell-Adipocyte". Paper presented in 27th Porto Cancer Meeting, 2021.
  30. Rodrigues R. ; Fernandes, R. ; Moreira-Barbosa, C. ; Pereira, F. ; Matos, A. Mendes, M. ; Oliveira, MJ; Ribeiro, R.; Cruz, T. "Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma | The Triad: Macrophage-Cancer Cell-Adipocyte". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  31. F Pereira, A Borges; Tania cruz; CA Reis, MJ Oliveira, A Preto. "The impact of KRAS/galectin-3 loop in colorectal tumor microenvironment". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC - Tumor Microenvironment, 2020.
  32. Ângela Marques-Magalhães, Marta Laranjeiro Pinto, Flávia Castro, Joana Caldeira, Sílvia Bidarra, Pedro Canão,; Cristina Barrias; Cruz, Tânia; Mário A. Barbosa, Hugo Osório, Fátima Carneiro, Ana Patrícia Cardoso, Raquel Gonçalves, Maria José Oliveira. "Colorectal cancer extracellular matrix: modulation of macrophage-derived CCL18". Paper presented in EACR-AACR-ASPIC Conference - Tumor Microenvironment, 2020.
  33. Leão, Teresa; Vieira, Maria; Carvalho, Sandra; Piller, Tatiana; Backx, Elyne; Cruz, Tânia; Castro, Helena; Duarte, Margarida; Tomas, AM. "How do Leishmania parasites, the agents of the leishmaniases, counteract zinc nutritional immunity?". Paper presented in Cell Biology of Metals Gordon Research Conference, 2019.
  34. Cruz, Tânia; M. Gouveia, P. Matafome, R. Soares, M. J. Oliveira, R. Travasso. "Modeling angiogenesis in type 2 diabetes mellitus: integrating experimental and theoretical approaches". Paper presented in 8th i3S annual meeting, 2019.
  35. Leão, Teresa; Carvalho, Sandra; Backx, Elyne; Cruz, Tânia; Castro, Helena; Duarte, Margarida; Tomas, AM. "Unraveling the zinc acquisition / homeostatic machinery of the human parasite Leishmania". Paper presented in Microbiology Society Annual Conference 2018, 2018.
  36. Ana Gomes-Alves, Aida Varela-Moreira; Tania cruz; Margarida Duarte, Yvonne te Welscher, Helena Castro, Rui Moreira, Ana S. Ressureição, Wim E. Hennink, Gert Storm, Ana M.. "p-p stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis". Paper presented in 15th edition of the European Symposium on Controlled Drug Delivery, 2018.
  37. Tania cruz; Maria Vieira, Joana Passos, Margarida Duarte, François Cannone-Hergaux, Jorge Pinto, Ana Tomás. "Ferroportin downregulation in the liver of leishmania infantum-infected mice through a hepcidin-independent mechanism". Paper presented in 7th Congress of the International BioIron Society (IBIS) Biennial World Meeting, 2017.
  38. Tania cruz; Ana Gomes-Alves, Margarida Duarte, Rui Moreira, Ana S. Ressureição, Ana M. Tomás.. "In vitro screening for compounds with activity against cutaneous and visceral leishmaniasis". Paper presented in 4th COST Action CM1307, 2017.
  39. Leão, Teresa; Carvalho, Sandra; Backx, Elyne; Cruz, Tânia; Castro, Helena; Duarte, Margarida; Tomas, AM. "The ZIP3 and CDF1 transporters, two proteins that allow Leishmania parasites to acquire zinc in a highly regulated way". Paper presented in Zinc-Net/Zinc-UK Meeting, 2016.
  40. Cruz, Tânia; . Duarte, H. Castro, J. Passos, F. Cannone-Hergaux, J.P. Pinto, A.M. Tomás. "Ferroportin-1 downregulation in the liver of Leishmania infantum-infected mice occurs through a hepcidin-independent mechanism". Paper presented in I3S Annual Meeting, 2016.
  41. Ana Tomás, Ana Ressureição; Tania cruz; Ana G. Alves, Helena Castro, Rui Moreira. "Anti-Leishmania activity of a set of Torin 2 analogues". Paper presented in COST Action CM1307/CaPF joint meeting, 2014.
  42. Cruz, Tânia; Passos J., Vieira I., Cannone-Hergaux F., Pinto J., Tomás A.M. "Leishmania infantum in vivo infection modulates host iron metabolism proteins". Paper presented in I3S Annual Meeting, 2014.
  43. Cruz, Tânia; Passos, Joana; Lima, Nuno; Castro, Helena; Cannone-Hergaux, François; Pinto, Jorge; Tomas, AM. "Impact of Leishmania infantum on macrophage iron metabolism proteins". Paper presented in Worldleish 5 | Fifth World Congress on Leishmaniasis, 2013.
  44. Cruz, Tânia; Sandra Carvalho, Filipa Teixeira, Helena Castro, François Cannone-Hergaux, Jorge Pinto, Ana M. Tomás. "Leishmania infantum infection modulates the expression of different macrophage iron metabolism proteins". Paper presented in International BioIron Society, 2011.
  45. Cruz, Tânia; Carvalho S., Teixeira F., Castro H., Cannone-Hergaux F., Pinto J., Tomás A.M.. "Leishmania infantum infection modulates the expression of different macrophage iron metabolism proteins". Paper presented in I3S Annual Meeting, 2011.
  46. Tania cruz; Sandra Carvalho, Pinto J., Gomes S., A.M. Tomás. "Aspects of the Iron-heme metabolism in the Leishmania infantum". Paper presented in I3S Annual Meeting, 2010.
    10.3390/mol2net-04-06141
  47. Sandra Carvalho; Tania cruz; Rosa Silva, Nuno Santarém, Helena Castro, Vítor Costa and Ana M. Tomás. "Iron acquisition in Leishmania infantum amastigotes.". Paper presented in 4 Wordl Congress on Leishmaniasis, 2009.
  48. Cruz, Tânia; Sandra Carvalho, Ana M. Tomás. "Iron-Heme Metabolism in Leishmania infantum intracellular stage". Paper presented in International BioIron Society, 2009.
  49. Cruz, Tânia; Sandra Carvalho, Vitor Costa, Ana Tomás. "Characterization of a putative ferric reductase and zinc-iron transporter members in Leishmania infantum". Paper presented in Kinetoplastid Molecular Cell Biology Meeting, 2009.
  50. Sandra Carvalho; Tania cruz; Rosa da Silva, Vitor Costa, Ana Tomás. "ZIP Transporters in Leishmania infantum". Paper presented in European Iron Club, Annual Meeting, 2008.
  51. Ana Margarida Vigário; Tania cruz; Hélène Dujardin, António Bandeira, Sylviane Pied. "Regulatory CD4+CD25+ T cells expand during Plasmodium infection but do not prevent cerebral malaria". Paper presented in First Annual BioMalPar Conference on Biology and Pathology of the Malaria Parasite, 2005.
Journal article
  1. M. Manuela Brás; Aureliana Sousa; Tânia B. Cruz; Jonas Michalewski; Marina Leite; Susana R. Sousa; Pedro L. Granja; Manfred Radmacher. "Microrheological comparison of melanoma cells by atomic force microscopy". Journal of Biological Physics (2024): https://doi.org/10.1007/s10867-023-09648-w.
    10.1007/s10867-023-09648-w
  2. Diogo Estêvão; Miguel da Cruz-Ribeiro; Ana P. Cardoso; Ângela M. Costa; Maria J. Oliveira; Tiago L. Duarte; Tânia B. da Cruz; Estêvão, Diogo; da Cruz-Ribeiro, Miguel; Cardoso, AP; Angela M Costa; Maria José Oliveira; Duarte, Tiago L; Cruz, Tânia. Corresponding author: Cruz, Tânia. "Iron metabolism in colorectal cancer: a balancing act". Cellular Oncology (2023): https://doi.org/10.1007/s13402-023-00828-3.
    Accepted • 10.1007/s13402-023-00828-3
  3. Silveira, Maria José; Martins, Cláudia; Cruz, Tânia; Castro, Flávia; Amorim-Costa, Ângela; Chester, Kerry; Oliveira, Maria José; Sarmento, Bruno. "scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells". Journal of Nanobiotechnology 21 1 (2023): http://dx.doi.org/10.1186/s12951-023-02126-4.
    10.1186/s12951-023-02126-4
  4. Eva Blondeel, Dr Filippo Piccinini, Sayida Al-Jamei, Dr Martina Bedeschi, Professor Gastone Castellani; Cruz, Tânia; Lise De Moor, Sándor Dedeyne, Diogo Estêvão, Maria Oliveira, Satoru Kawakita, Huu Tuan Nguyen, Leoni Kunz-Schughart, Soo. "SLiMIA: the Spheroid Light Microscopy Image Atlas". Scientific Data Journal (2023):
    Under revision
  5. Pinto, Ana Teresa; Machado, Ana Beatriz; Osório, Hugo; Pinto, Marta Laranjeiro; Vitorino, Rui; Justino, Gonçalo; Santa, Cátia; et al. "Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression". Cancers 15 1 (2022): 270. http://dx.doi.org/10.3390/cancers15010270.
    Open access • Published • 10.3390/cancers15010270
  6. Brás, M. Manuela; Cruz, Tânia; Maia, André F.; Oliveira, Maria José; Sousa, Susana R.; Granja, Pedro L.; Radmacher, Manfred. "Mechanical Properties of Colorectal Cancer Cells Determined by Dynamic Atomic Force Microscopy: A Novel Biomarker". Cancers 14 20 (2022): 5053. http://dx.doi.org/10.3390/cancers14205053.
    Published
  7. Marques-Magalhães, Ângela; Cruz, Tânia; Costa, Ângela Margarida; Estêvão, Diogo; Rios, Elisabete; Canão, Pedro Amoroso; Velho, Sérgia; et al. "Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds for Studying Tumor-Stroma Interactions". Cancers 14 2 (2022): 359. http://dx.doi.org/10.3390/cancers14020359.
    10.3390/cancers14020359
  8. Cruz, Tânia B.; Carvalho, Filomena A.; Matafome, Paulo N.; Soares, Raquel A.; Santos, Nuno C.; Travasso, Rui D.; Oliveira, Maria J.. "Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features". Biomedicines 10 1 (2021): 57. http://dx.doi.org/10.3390/biomedicines10010057.
    Published • 10.3390/biomedicines10010057
  9. Cardoso, Ana Patrícia; Pinto, Marta Laranjeiro; Castro, Flávia; Costa, Ângela Margarida; Marques-Magalhães, Ângela; Canha-Borges, Ana; Cruz, Tânia; Velho, Sérgia; Oliveira, Maria José. "The immunosuppressive and pro-tumor functions of CCL18 at the tumor microenvironment". Cytokine & Growth Factor Reviews (2021): http://dx.doi.org/10.1016/j.cytogfr.2021.03.005.
    Published • 10.1016/j.cytogfr.2021.03.005
  10. Ana Gomes Alves, Margarida Duarte,; Cruz, Tânia; Helena Castro, Francisca Lopes, Rui Moreira; Ana Tomás, Ana Ressurreição. "Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evaluation and mechanistic studies". Antimicrobial Agents and Chemotherapy (2021):
    Accepted
  11. Silva-Carvalho, R.; Fidalgo, J.; Melo, K.R.; Queiroz, M.F.; Leal, S.; Rocha, H.A.; Cruz, T.; et al. "Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis". International Journal of Biological Macromolecules 153 (2020): 276-288. http://dx.doi.org/10.1016/j.ijbiomac.2020.03.019.
    10.1016/j.ijbiomac.2020.03.019
  12. Castro, Helena; Cruz, Tânia; de Aguiar Amaral, Patrícia; da Silva Cardoso, Paula; Alsaffar, Ahmed; Farrell, Patrick; Tomás, Ana M.; Barlow, James W.. "Synthesis and evaluation of novel chromanone and quinolinone analogues of uniflorol as anti-leishmanial agents". Heliyon 6 3 (2020): e03614. http://dx.doi.org/10.1016/j.heliyon.2020.e03614.
    Published • 10.1016/j.heliyon.2020.e03614
  13. Helena Castro , Maria Inês Rocha, Ricardo Silva, Filipe Oliveira, Ana Georgina Gomes-Alves; Tania cruz; Margarida Duarte, Ana Maria Tomás. "Functional insight into the glycosomal peroxiredoxin of Leishmania.". Acta tropica (2019): https://doi.org/10.1016/j.actatropica.2019.105217.
    10.1016/j.actatropica.2019.105217
  14. Ana G. Gomes-Alves, André F. Maia; Tania cruz; Helena Castro, Ana M. Tomás. "Development of an automated image analysis protocol for quantification of intracellular forms of Leishmania spp.". PLOS ONE (2018): http://dx.doi.org/10.1371/journal.pone.0201747.
    10.1371/journal.pone.0201747
  15. Teixeira F; Castro H; Cruz T; Tse E; Koldewey P; Southworth DR; Tomás AM; Jakob U. "Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.". (2015): http://europepmc.org/abstract/med/25646478.
    10.1073/pnas.1419682112
  16. Cruz, T.; Vale-Costa, S.; Marques, F.; Marques, J.M.; Silva, T.; Neves, J.V.; Fernandes, A.; et al. "Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection". Parasites and Vectors 8 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84950313576&partnerID=MN8TOARS.
    10.1186/s13071-015-1259-6
  17. Ferro, L.; Marques, M.; Leal, P.; Romão, S.; Cruz, T.; Tomás, A.M.; Castro, H.; Quelhas, P.. "Automatic spectral unmixing of Leishmania infection macrophage cell cultures image". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7950 LNCS (2013): 621-629. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884486489&partnerID=MN8TOARS.
    10.1007/978-3-642-39094-4_71
  18. Leal, P.; Ferro, L.; Marques, M.; Romão, S.; Cruz, T.; Tomá, A.M.; Castro, H.; Quelhas, P.. "Automatic assessment of Leishmania infection indexes on in vitro macrophage cell cultures". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7325 LNCS PART 2 (2012): 432-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864131020&partnerID=MN8TOARS.
    10.1007/978-3-642-31298-4_51
  19. Castro H; Teixeira F; Romao S; Santos M; Cruz T; Flórido M; Appelberg R; et al. "Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.". (2011): http://europepmc.org/abstract/med/22046130.
    10.1371/journal.ppat.1002325
  20. Cruz, T.; Carvalho, S.; Santarém, N.; Castro, H.; Costa, V.; Tomás, A.M.. "Heme as a source of iron to Leishmania infantum amastigotes". Acta Tropica 109 2 (2009): 131-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-57849159746&partnerID=MN8TOARS.
    10.1016/j.actatropica.2008.10.007
  21. Vigário, A.M.; Gorgette, O.; Dujardin, H.C.; Cruz, T.; Cazenave, P.-A.; Six, A.; Bandeira, A.; Pied, S.. "Regulatory CD4+CD25+ Foxp3+ T cells expand during experimental Plasmodium infection but do not prevent cerebral malaria". International Journal for Parasitology 37 8-9 (2007): 963-973. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249947689&partnerID=MN8TOARS.
    10.1016/j.ijpara.2007.01.004
Thesis / Dissertation
  1. Cruz, Tânia. "Iron metabolism in the context of a Leishmania infantum infection". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2012.
  2. Cruz, Tânia. "The effect of red blood cells in T cell proliferation and its relation with malaria pathology". Degree, Universidade Lusófona de Humanidades e Tecnologias, 2004.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 RADIOCOMMUNICATION: UNRAVELING THE ROLE OF EXTRACELLULAR VESICLES IN RECTAL CANCER RADIORESISTANCE IJUP 2023
Universidade do Porto
2022 Radiotherapy effect on rectal cancer secretome 6th Symposium of the MSc in Oncology
IPO-Porto (Porto, Portugal)
2022 Unveil the biochemical and biomechanical properties of colorectal cancer patients-derived tissues from different colon locations FEBS Advanced Course “Matrix Pathobiology, Signaling and Molecular Targets
FEBS
2022 Goodbye flat biology: Development of a 3D rectal cancer spheroid 4th Symposium on Immunomodulation in Cancer & Regeneration Committee
Institute for Investigation and Innovation in Health - i3S
2022 3D RECTAL CANCER SPHEROID: A NEW TOOL FOR UNCOVERING NOVEL THERAPEUTIC TARGETS. EMBO|FEBS Lecture course Molecular Mechanisms in signal transduction and cancer
EMBO
2021/10/06 Modeling angiogenesis in type 2 diabetes mellitus: integrating experimental and theoretical approaches EMBO workshop - Vascular malformations: From fundamental biology to therapeutic opportunities
Institut de Recerca contra la Leucèmia Josep Carreras (Badalona, Spain)
2021/04/15 Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma: "The triad: macrophage-cancer cell-adipocyte" III Jornadas Ibéricas de Genética Y Biotecnologia
UTAD, Bragança (Portugal)
2021 Decoding novel therapeutic targets against rectal cancer: iron metabolism and immune microenvironment 4Th PhDay Break borders build opportunities
Institute for Investigation and Innovation in Health - i3S (Portugal)
2021 Perirenal Adipose Tissue and Clear Cell Renal Cell Carcinoma | The triad: macrophage-cancer cell-adipocyte 5th Symposium of the MSc in Oncology
IPO-Porto (Portugal)
2021 Perirenal adipose tissue and clear cell renal cell carcinoma: The triad: macrophage-cancer cell-adipocyte iMED conference 13.0 iNNOVATE competition
Fundação Astrazeneca (Portugal)
2016 Ferroportin-1 downregulation in the liver of Leishmania infantum-infected mice occurs through a hepcidin-independent mechanism i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 Unraveling the mechanisms by which Leishmania infantum parasites obtain zinc and iron ON.2 Symposium on Host-Pathogen Interactions Meeting
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 Progress towards the development of the “CellNote” software: a platform for determination of intracellular parasitaemia in Leishmania infected macrophages. Cost Action – “New drugs for Neglected Diseases
(Italy)
2010 Leishmania infantum and Iron Metabolism PhD seminars
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal (Porto, Portugal)
2008 Leishmania infantum can use both heme and non-heme iron sources European Iron Club
(Switzerland)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/10/01 - Current Decoding novel therapeutic targets against rectal cancer iron metabolism and immune microenvironment
Supervisor of Diogo Estevão
PhD in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Cancer Research Institute Ghent, Belgium
2022/03 - 2023/12 Study of the adipose tissue role in renal cell carcinoma
Co-supervisor of Eduarda Pinto
Master (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2021 - 2022 DECIPHER: The radiotherapy effect on rectal cancer immunospheroid secretome
Supervisor of Miguel da Cruz Ribeiro
Master in Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Cancer Research Institute Ghent, Belgium
2020/11 - 2021 Perirenal Adipose Tissue and Renal Cell Carcinoma.
Supervisor of Rafaela Rodrigues
Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/07 - 2020/09 Study of Hyperglycemia and Fibrosis Association using animal models: diabetes-cancer link insights
Supervisor of Rafaela Rodrigues
PRÁTICA LABORATORIAL/CLÍNICA SUPERVISIONADA (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 Uncovering the mechanism of ferroportin-1 downmodulation upon Leishmania infantum infection
Supervisor of Maria Vieira
Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2016 Development of systems to facilitate target identification and drug-development in Leishmania infantum
Co-supervisor of Elyne Backx
Ciências Biomédicas (Master)
Universiteit Antwerpen, Belgium
2014 - 2014 Modulation of the macrophage iron metabolism upon infection with Leishmania infantum
Supervisor of Marta Miranda
Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2011 Leishmania and iron interaction
Co-supervisor of Nuno Lima
Enfermagem Veterinária (Degree)
Instituto Politécnico de Viana do Castelo Escola Superior Agrária, Portugal
2009 - 2009 Study of Leishmania infantum iron acquisition proteins
Co-supervisor of Ana Rosalina Ribeiro
Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2014/07/17 - 2014/07/17 ON.2 Symposium on Host-Pathogen Interactions Meeting (2014/07/17 - 2014/07/17)
Conference (President of the Organising Committee)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2002 - 2002 Biology National Student Meeting* Encontro Nacional de Estudantes de Biologia (ENEB) (2002 - 2002)
Congress (Member of the Organising Committee)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/03/30 - 2023/03/30 1st Workshop on Modelling Immuno-Oncology, IMMUNO-model COST Action (CA21135)
Workshop
1st Workshop “Modelling Immuno-Oncology”
Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Spain
2022/11/11 - 2022/11/11 i3S Annual Meeting
Meeting
i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/09 - 2022/09 6th Edition | The International Conference on Immunotherapy Radiotherapy Combinations
Conference
Conference on Immunotherapy Radiotherapy Combinations
Gustave Roussy, France

Weill Cornell Medicine Department of Radiation Oncology, United States
2022/07/23 - 2022/07/23 4th Symposium in Immunomodulation in cancer and regeneration
Symposium
IMMUNOMODULATION IN CANCER AND REGENERATION SYMPOSIUM
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Associação Portuguesa de Investigação em Cancro, Portugal
2022/06 - 2022/06 EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine
Congress
EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine
European Association For Cancer Research, United Kingdom
2021/10/14 - 2021/10/15 II ASPIC ASEICA meeting
Conference
II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2021/10/06 - 2021/10/08 EMBO workshop on Vascular malformations: From fundamental biology to therapeutic opportunities
Workshop
Vascular malformations: From fundamental biology to therapeutic opportunities
Institut de Recerca Contra la Leucemia Josep Carreras, Spain

EMBO Press, Germany
2021/10/05 - 2021/10/06 EACR - Goodbye Flat Biology Meeting
Conference
EACR Goodbye Flat Biology: Next Generation Cancer Models
European Association For Cancer Research, United Kingdom
2021/09/30 - 2021/09/30 European Iron Club - Iron Zoomposium
Symposium
European Iron Club - Iron Zoomposium
University of Oxford Medical Sciences Division, United Kingdom
2021/09/24 - 2021/09/24 3º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA
Conference
3º Encontro nacional de jovens investigadores em oncologia - ENJIO
Liga Portuguesa Contra o Cancro, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2019/06/25 - 2019/06/25 Symposium on immunomodulation in cancer and regeneration
Conference
T cells and immunotherapies
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/05/02 - 2019/05/03 Porto Cancer Meeting & PORTO-BORDEAUX joint meeting
Congress
The cancer ecosystem
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2019/04/01 - 2019/04/02 COST action EuroCellNet (CA15214)
Meeting
"Mechanobiology of Migrating Cells – from basic science to the clinic"
Universidade de Coimbra Centro de Física, Portugal
2019 - 2019 8th i3S Annual Meeting
Meeting
i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 7th Congress of the International BioIron Society - Biennial World (Los Angeles, USA)
Congress
International BioIron Society (IBIS) Biennial World
International Bioiron Society , United States
2016 - 2016 5th i3S Annual Meeting
Meeting
i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2014 I3S Annual Meeting
Meeting
I3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2014 ON.2 Symposium on Host-Pathogen Interactions
Symposium
Host-Pathogen Interactions
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011/05/05 - 2011/05/06 2nd i3S Scientific Retreat
Meeting
i3S Scientific Retreat
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011 - 2011 4th Congress of the International BioIron Society (Vancouver, Canada)
Congress
International BioIron Society
International Bioiron Society , United States
2010/05/06 - 2010/05/07 1st i3S Scientific Retreat
Meeting
1st i3S Scientific Retreat
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - 2010 DNDi COST Action CM0801 - New drugs for neglected diseases
Meeting
New Drugs for Neglected Diseases
Universiteit Antwerpen, Belgium
2009 - 2009 3rd congress of the International BioIron Society (Porto, Portugal)
Congress
International BioIron Society
International Bioiron Society , United States
2008 - 2008 European Iron Club (St Gallen, Switzerland)
Congress
European Iron Club
European Iron Club, Switzerland

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/10/31 Understanding the role of extracellular vesicles derived from mutant kras colorectal cancer cells on T-cell activation and exhaustion
(Thesis) Main arguer
Ana Catarina Azevedo Costa (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/07/15 Immune regulation of serum iron binding proteins profile during Mycobacterial infection
(Thesis) Arguer
Maria Carolina Sousa Almeida (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/06/23 The impact of FLVCR1 loss in human hepatoma cell lines
(Thesis) Arguer
Catarina Neves Godinho (Other)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/07/18 Promastigotes from different Leishmania infantum strains present distinct susceptibilities to oxidative stress
(Thesis) Main arguer
Pedro Simões Ruas (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023/08 - Current Frontiers in Gastroenterology frontiers
2023/01/01 - Current CCHTS - Combinatorial Chemistry & High Throughput Screening (1386-2073) Bentham Science Publishers
2022/12/01 - Current Drug Delivery and Translational Research (21903948) Springer Publishing Company
2015 - Current PLoS One (1932-6203) Public Library of Science

Association member

Society Organization name Role
2022/02/28 - Current BioIron - International Society for the study of Iron in Biology and Medicine Member
2022 - Current ESTro | European Society Radiation Oncology Member
2021/06/21 - Current EACR - European Association for Cancer Research Ambassador
2021/06/01 - Current ASPIC - Associação Portuguesa de Investigação em Cancro Member

Committee member

Activity description
Role
Institution / Organization
2023/03/01 - Current CA21135 - Modelling immunotherapy response and toxicity in cancer (IMMUNO-model) Cost Action member
Member
Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Spain
2022/11 - Current COST Expert Invited to either take part in: Open Call evaluation as an external expert; Open Call as a review panel member; Monitoring of COST Actions
Member
European Cooperation in Science and Technology, Belgium
2022 - Current Supervisor of the International Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences https://www.biotechhealth.pt/phd-programme#Supervision
Other
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/01/27 - Current Global Talent Mentoring uses a self-developed, specialized platform that enables and supports mentoring for talented students all over the world. Global Talent Mentoring is supported by its global network of partner institutions that help find talented students in STEMM domains and recruit extraordinary researchers and professionals who excel in their STEMM area and serve as mentors for Global Talent Mentoring.
Member
Global Talent Mentoring, Germany

Conference scientific committee

Conference name Conference host
2022/10/03 - 2022/10/04 5th PhDay - Building Paths: The science behind us Institute for Investigation and Innovation in Health - i3S
2020/10/01 - 2020/10/01 3rd PhDay | Back to the Future i3S, Instituto de Investigação e Inovação em Saúde in Porto, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2008 - 2019 Lecturer in the GABBA Doctoral Program. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2018/12/19 - 2018/12/19 Microbiology | Host-Pathogen interactions | Antibiotic resistance in healthcare institutions Enfermagem (Licenciatura) Escola Superior de Enfermagem da Cruz Vermelha Portuguesa de Oliveira de Azeméis, Portugal
2008 - 2011 BioBigBrother – Observe a parasite life (Ensino secundário) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Ciência Viva, Portugal
2009 - 2009 Porto de Crianças, Taxonomic wheel of life Escola Primária da Torrinha (Ensino básico 3º ciclo) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Câmara Municipal do Porto, Portugal
2008 - 2008 “Ocupação Científica nas Férias – Jovens Ciência Viva nos Laboratórios”. Iron metabolism in parasites (Ensino secundário) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Ciência Viva, Portugal

Mentoring / Tutoring

Topic Student name
2022/11/01 - Current Studying the EV-mediated effect of pancreatic stellate cells on PDAC response Rita Rebelo
2022 - Current Dissect the tumor microenvironment to battle cancer radioresistance and immune escape Ana Manuela Canha-Borges
2022/02/01 - 2023/10/31 The role of CD24 in meduloblastoma Rui Pedro Marques
2020 - 2023 Dissecting the modulation of CCL18 at the colorectal cancer microenvironment: impact on invasion and immune escape Angela Magalhães
2019 - 2023 The impact of KRAS/galectin-3 loop in colorectal tumor microenvironment Flávia Pereira
2019 - 2023 Translational studies on the role of adipocytes in tumor microenvironment in B cell Lymphoma Andreia Matos
2020 - 2022 Energetic metabolism in ovarian cancer dissemination: tumor-host crosstalk Catarina Barbosa
2020 - 2021 The impact of ionizing radiation on macrophage iron metabolism and macrophage-cancer cell crosstalk Ana Beatriz Delgado Machado
2019 - 2020 Role of CCL18 on Colorectal Cancer Immune Modulation Ana Manuela Canha-Borges
2017 - 2018 Development of a water-soluble Dextrin-Amphotericin B formulation for the treatment of Leishmaniasis Fidalgo, João Miguel Pereira
2017 - 2018 AIP56, the toxin of the sea bass pathogen Photobacterium damselae subsp. piscicida, as a possible drug and/or antigen delivery system for leishmaniasis Dirkx, Laura
2015 - 2018 p-p stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis Gomes-Alves, Ana Georgina
2010 - 2015 The mitochondrial peroxiredoxin of Leishmania – a novel member of the parasite chaperone network, crucial for infection Teixeira, Filipa Daniela Pinheiro
2011 - 2012 Investigation of trypanothione reductase inhibitory activity by 1,2,4-thiadiazolium-2-aminide derivatives and molecular docking studies Rodrigues, Raquel

Other jury / evaluation

Activity description Institution / Organization
2022/11/17 - 2022/11/17 Main arguer of the 1st year Ph.D. defense of Cristiana Andreia Pereira Nogueira. Ph.D. in Biomedical Sciences, by ICBAS, UP. Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/10/14 - 2022/10/14 Main arguer of the 1st year Ph.D. defense of Maria Miguel Ferreira Pinto Menezes de Castro. Ph.D. in Biomedicine, by FMUP, UP. Universidade do Porto Faculdade de Medicina, Portugal
2019 - 2020 IJUP - Encontro de Investigação Jovem da U.Porto Universidade do Porto, Portugal
Distinctions

Award

2021 Exclusive Grant for Gene Expression Panels Award
NanoString Technologies Inc Europe, United Kingdom
2017 Young Travel Investigator Award | IBIS International Meeting, Los Angeles, USA
International Bioiron Society , United States
2008 Young Investigator Travel Award | EIC Meeting St. Gallen, Switzerland.
European Iron Club, Switzerland

Other distinction

2010 DNDi COST Action CM0801 | Short Term Scientific Mission | Microbiology Parasitology and Hygiene Lab, Antwerp University.
Universiteit Antwerpen, Belgium
2006 PhD fellowship | SFRH/BD/23352/2005
Fundação para a Ciência e a Tecnologia, Portugal