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Rui Moreira is a medicinal chemist by training, with a Master in Pharmaceutical Sciences and Industrial Pharmacy (1986) and a PhD degree in Pharmacy/Medicinal Chemistry (1991) from the University of Lisbon. After completing the compulsory military service in 1992, he visited the Department of Chemistry at The Open University UK, as a postdoctoral researcher. He joined the Faculty of Pharmacy at the University of Lisbon (FFUL) in 1992 as an assistant professor and went up the ranks to be a Full Professor in 2006. From 2010 to 2013, Rui Moreira was the coordinator of the Research Institute for Medicines (iMed.ULisboa), and since 2022 he is the president of the Department of Pharmaceutical Sciences and Medicines at FFUL, overseeing the activities of ca. 100 professors, lecturers, researchers, and technicians. He is a co-founder and board member of PT-OPENSCREEN, a national infrastructure for chemical biology and genetics, which recently joined the ERIC EU-OPENSCREEN (EU-OS). Rui Moreira is the leader of iMed.ULisboa’s Medicinal Chemistry Partner Site at EU-OS since 2022. He was the President the European Federation for Medicinal Chemistry and Chemical Biology (EFMC) from 2021 to 2023, being currently its Past President. Rui Moreira leads the medicinal chemistry research group at iMed.ULisboa, which comprises 3 associate researchers, 2 postdocs, and 10 PhD students, and 4 MSc students. He published 180 papers, including in high impact journals such as J Amer Chem Soc, Angew Chem, Proc Natl Acad Sci and J Med Chem, and has delivered more than 60 talks. He successfully (co)supervised >50 PhD/MSc students and postdocs and has been funded through competitive projects and grants from national and EU programs.
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Identification

Personal identification

Full name
Rui Moreira

Citation names

  • Moreira, Rui

Author identifiers

Ciência ID
8B11-E8C0-DFD0
ORCID iD
0000-0003-0727-9852
Researcher Id
G-7485-2011
Scopus Author Id
7102554088

Email addresses

  • rmoreira@ff.ul.pt (Professional)

Addresses

  • Faculty of Pharmacy, University of Lisbon, Av. Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2004
Concluded
 Pharmaceutical Sciences (Título de Agregado)
Major in Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/06
Concluded
 Farmácia (Doutoramento)
Major in Pharmaceutical and Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Contribution to the development of prodrugs for several anticancer agents" (THESIS/DISSERTATION)
1980 - 1985/07
Concluded
 Ciências Farmacêuticas (Licenciatura)
Major in Industrial Pharmacy
Universidade de Lisboa Faculdade de Farmácia, Portugal
 18/20
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2006/10/01 - Current Full Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
(...)
2002/10/01 - 2006/10/31 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/10/01 - 2002/09/30 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2018/10/01 - 2021/09/30 Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents RuGly
PTDC/MED-QUI/31468/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2021/09 NPSTEENSBRAIN. New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain Exposure
PTDC/SAU-TOX/32515/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2014/01 - 2015/12 Incentive - UI 4013 - 2014
Provided by PTCRIS: 137395
Principal investigator
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2024/02/01 - 2027/01/31 IMPULSE. IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN
DLV-101132028
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2023/03/01 - 2026/02/28 FRAGMENT-SCREEN
101094131
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Horizon 2020
Ongoing
2022 - 2026 OncoProTools
101073231
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Ongoing
2023/01/01 - 2025/12 Ferrous Iron-Activable Drug Conjugates: Targeting Iron Metabolism in the Era of Precision Oncology
2022.07857.PTDC
Principal investigator
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
2022/06 - 2024/06 Iron-triggered technologies as a novel targeted therapy for cancer
LCF/TR/CI22/52660003
Co-Principal Investigator (Co-PI)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação 'la Caixa'
2018/10/01 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Principal investigator
Universidade Nova de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/10 - 2021/08/09 Dialysis membranes by design: targeting neutrophil elastase to reduce inflammation/oxidative stress in end-stage renal disease
PTDC/MEC-CAR/31322/2017
PTDC/MED-CAR/31322/2017
POCI-01-0145-FEDER-031322
POCI-01-0145-FEDER-031322
Researcher
Universidade de Coimbra, Portugal

Universidade do Porto, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2021/05/31 Fígado Gordo Não-alcoólico: Biomarcardores, Alvos e Terapias Emergentes
PTDC/MED-FAR/29097/2017
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2021/05/31 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MED-FAR/30266/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2020/12/31 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Instituto Politécnico de Leiria, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2020/06/30 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade da Beira Interior, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2019/12/31 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
PTDC/QEQ-MED/7097/2014
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/12/31 ProbeCOPD. Protease activity-based probes for Chronic Obstructive Pulmonary Disease diagnostics
PTDC/BBB-BEP/2463/2014
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/06/30 New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
PTDC/BIM-MEC/0895/2014
Centro Hospitalar de Lisboa Central EPE, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/15 - 2015/10/14 BioClick@LSMal. Bioorthogonal clickable probes to target the liver stage of malaria
EXPL/QEQ-MED/1574/2013
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
PTDC/SAU-FAR/118459/2010
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/24 - 2014/12/25 Exploring a new approach to target KRAS oncogene
EXPL/QEQ-MED/0502/2012
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS
PTDC/SAU-FAR/114864/2009
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/30 New drugs for treating and eradicating malaria
HMSP-CT/SAU-ICT/0068/2009
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Targeting the mitochondrial electron transport chain of malaria parasites: computer-assisted design and synthesis of bc1 complex inhibitors as antimalarial agents
PTDC/SAU-FCF/098734/2008
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/07/01 - 2011/12/31 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
NANO/NMed-AT/0042/2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/12/30 Rhodium catalysed C-H bond activation and C-C bond formation in water and bio-compatible solvents - An expeditious way to prepare biologically active heterocycles
PTDC/QUI/66695/2006
Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/11/02 - 2011/10/31 Chemical reactivity as a tool in drug design: modification of the beta-lactam scaffold to improve serine protease inhibition
PTDC/QUI/64056/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/08/01 - 2007/09/30 Biochemical characterization and inhibition studies of recombinant cysteine proteases of Plasmodium chabaudi, an animal model for human malaria.
POCI/SAU-ESP/57696/2004
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. da Silva, G.; Moreira, R.; Silva, A.M.S.. "Bioactive Quinolactacins and Structurally Related Pyrroloquinolones". 433-453. 2019.
    10.1016/B978-0-444-64185-4.00012-5
  2. Moreira, Rui; Dias, A. F.; Ressurreição, Ana Sofia. "One-Step Synthesis of 4(3H)-Quinazolinones: An Important Heterocyclic Scaffold in Medicinal Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Published
  3. Moreira, Rui; Lavrado, J.; Figueiras, M.; Pereira, D. M.; Santos, S. A.; Paulo, Alexandra. "Synthesis of Indolo[3,2-b]quinolin-11-one by Acid-Catalysed Intramolecular Double Cyclization". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Published
  4. Moreira, Rui; Ribeiro, C.J.A.; Santos, M.M.M.. "Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Published
  5. Moreira, Rui; Lucas, S.D.; Ruivo, E.F.P.; Figueiras, M.; Lavrado, J.. "Click Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Published
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". In Biomedical Chemistry: Current Trends and Developments, edited by Vale, Nuno. 2015.
    10.1515/9783110468755-002
  7. Sitoe, A.R.; Lopes, Francisca; Moreira, Rui; Varela Coelho, Ana; Bronze, Maria. "Contribution of Mass Spectrometry to the Study of Antimalarial Agents". In Tandem Mass Spectrometry-Molecular Characterization, edited by Varela Coelho, Ana. Poland: IntechOpen, 2013.
    Published
  8. Mulchande, Jalmira; Lopes, Francisca; Moreira, Rui. "Azetidin-2-ones and related systems as enzyme inhibitors: synthesis and reactivity". In Heterocyclic Targets in Advanced Organic Synthesis, edited by Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Published
  9. Lavrado, J.; Moreira, Rui; Paulo, Alexandra. "Synthetic strategies towards bioactive indolo[3,2-b]quinolines". In Heterocyclic Targets in Advanced Organic Synthesis, edited by Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Published
  10. Francisco, A.P.; Perry, M.D.J.; Moreira, R.; Mendes, E.. "Alkylating Agents". In Anticancer Therapeutics. Chichester, United Kingdom: Wiley-Blackwell, 2008.
    10.1002/9780470697047.ch9
Conference paper
  1. Inês Moranguinho; Pedro Borrego; João Lavrado; Rui Moreira; Nuno Taveira. "New Compound Combining an Integrase-Targeting Aptamer and a Small Interfering RNA Targeting the Trans-Activation Response/Poly A Region of HIV-1 Potently Suppresses HIV-1 Replication". 2023.
    10.3390/msf2023022023
  2. Rocha, Susana; Morgo¿ová, Kristína; Valente, Maria João; Amorim, Célia; Araújo, Alberto; Santos-Silva, Alice; Moreira, Rui; Branco da Silva Montenegro, Maria Conceição. "DOPING POLYSULFONE DIALYSIS MEMBRANES WITH HUMAN NEUTROPHIL ELASTASE INHIBITORS - A PILOT STUDY". Paper presented in Nephrology Dialysis Transplantation, 2021.
    10.1093/ndt/gfab113.002
Journal article
  1. Joana Gonçalves; Joana D. Amaral; Rita Capela; Maria de Jesus Perry; Cláudia Braga; Maria Manuela Gaspar; Fátima M. Piedade; et al. "Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors". Cell Death Discovery (2024): http://dx.doi.org/10.1038/s41420-024-02033-z.
    10.1038/s41420-024-02033-z
  2. Leite, Debora I.; Campaniço, Andre; Costa, Pedro A. G.; Correa, Isadora A.; da Costa, Luciana J.; Bastos, Monica M.; Moreira, Rui; et al. "New azaaurone derivatives as potential multitarget agents in HIV-TB coinfection". Archiv der Pharmazie 357 2 (2023): http://dx.doi.org/10.1002/ardp.202300560.
    10.1002/ardp.202300560
  3. Campaniço, André; Harjivan, Shrika G.; Freitas, Elisabete; Serafini, Marco; Gaspar, M. Manuela; Capela, Rita; Gomes, Pedro; et al. "Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability". ChemMedChem 18 24 (2023): http://dx.doi.org/10.1002/cmdc.202300410.
    10.1002/cmdc.202300410
  4. Yang, Jian; Carvalho, Luís A. R.; Ji, Shanping; Chen, Suyuan; Moreira, Rui; Verhelst, Steven H. L.. "4-Oxo-ß-Lactams as Novel Inhibitors for Rhomboid Proteases". ChemBioChem 24 21 (2023): http://dx.doi.org/10.1002/cbic.202300418.
    10.1002/cbic.202300418
  5. da Silva, Gustavo; André F. S. Luz; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; et al. Corresponding author: da Silva, Gustavo. "Facile access to structurally diverse antimalarial indoles using a one-pot A3 coupling and domino cyclization approach". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300264.
    10.1002/cmdc.202300264
  6. Debora Inacio Leite; Stefany de Castro Bazan Moura; Maria da Conceição Avelino Dias; Carolina Catta Preta Costa; Gustavo Peixoto Machado; Luiz Claudio Ferreira Pimentel; Frederico Silva Castelo Branco; et al. "A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens". Molecules (2023): https://doi.org/10.3390/molecules28083342.
    10.3390/molecules28083342
  7. Susana Rocha; Rita Félix; Maria Valente; Andreia Bento-Silva; Rute Rebelo; Célia Amorim; Alberto Araújo; et al. "Polysulfone Membranes Doped with Human Neutrophil Elastase Inhibitors: Assessment of Bioactivity and Biocompatibility". Membranes (2023): https://doi.org/10.3390/membranes13010089.
    10.3390/membranes13010089
  8. Chiara Borsari; Brieuc Matagne; Kristina Goncharenko; Rui Moreira; Yves P. Auberson. "The Facets of Diversity: The EFMC Perspective**". ChemMedChem (2023): https://doi.org/10.1002/cmdc.202200245.
    10.1002/cmdc.202200245
  9. Yang, J.; Carvalho, L.A.R.; Ji, S.; Chen, S.; Moreira, R.; Verhelst, S.H.L.. "4-Oxo-ß-Lactams as Novel Inhibitors for Rhomboid Proteases". ChemBioChem 24 21 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85171262930&partnerID=MN8TOARS.
    10.1002/cbic.202300418
  10. Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; et al. "Chemoproteomics-Enabled Identification of 4-Oxo-ß-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9". Angewandte Chemie International Edition 61 47 (2022): http://dx.doi.org/10.1002/anie.202210498.
    Published • 10.1002/anie.202210498
  11. Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; et al. "Chemoproteomik-basierte Identifikation von 4-Oxo-ß-lactamen als Inhibitoren der Dipeptidylpeptidasen 8¿und 9". Angewandte Chemie 134 47 (2022): http://dx.doi.org/10.1002/ange.202210498.
    Published • 10.1002/ange.202210498
  12. Natália Aniceto; Vanda Marques; Joana D. Amaral; Patrícia A. Serra; Rui Moreira; Cecília M. P. Rodrigues; Rita C. Guedes. "Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors". Molecules (2022): https://doi.org/10.3390/molecules27154718.
    10.3390/molecules27154718
  13. Rafael F. A. Gomes; Joao M. J. M. Ravasco; Késsia H. S. Andrade; Jaime A. S. Coelho; Rui Moreira; Rafael Oliveira; Fátima Nogueira; Carlos A. M. Afonso. "Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived d-Lactone-Fused Cyclopentenones". ChemSusChem (2022): https://doi.org/10.1002/cssc.202102204.
    10.1002/cssc.202102204
  14. Solida Long; Denise Duarte; Carla Carvalho; Rafael Oliveira; Nuno Santarém; Andreia Palmeira; Diana I. S. P. Resende; et al. "Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids". ACS Medicinal Chemistry Letters (2022): https://doi.org/10.1021/acsmedchemlett.1c00589.
    10.1021/acsmedchemlett.1c00589
  15. Liu, X.; Kalogeropulou, A.F.; Domingos, S.; Makukhin, N.; Nirujogi, R.S.; Singh, F.; Shpiro, N.; et al. "Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2". Journal of the American Chemical Society 144 37 (2022): 16930-16952. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137398154&partnerID=MN8TOARS.
    10.1021/jacs.2c05499
  16. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita G. Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences 22 10 (2021): 5289-5289. https://doi.org/10.3390/ijms22105289.
    10.3390/ijms22105289
  17. Almeida, A.F.; Ataíde, F.A.P.; Loureiro, R.M.S.; Moreira, R.; Rodrigues, T.. "Augmenting Adaptive Machine Learning with Kinetic Modeling for Reaction Optimization". Journal of Organic Chemistry 86 20 (2021): 14192-14198. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110973936&partnerID=MN8TOARS.
    10.1021/acs.joc.1c01038
  18. Miethke, M.; Pieroni, M.; Weber, T.; Brönstrup, M.; Hammann, P.; Halby, L.; Arimondo, P.B.; et al. "Towards the sustainable discovery and development of new antibiotics". Nature Reviews Chemistry 5 10 (2021): 726-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110714419&partnerID=MN8TOARS.
    10.1038/s41570-021-00313-1
  19. Barbosa, M.; Gomes, C.; Sequeira, C.; Gonçalves-Ribeiro, J.; Pina, C.C.; Carvalho, L.A.; Moreira, R.; et al. "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105432735&partnerID=MN8TOARS.
    10.3389/fcell.2021.634355
  20. Gomes-Alves, A.G.; Duarte, M.; Cruz, T.; Castro, H.; Lopes, F.; Moreira, R.; Ressurreição, A.S.; Tomás, A.M.. "Biological evaluation and mechanistic studies of quinolin-(1H)-imines as a new chemotype against leishmaniasis". Antimicrobial Agents and Chemotherapy 65 7 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108296688&partnerID=MN8TOARS.
    10.1128/AAC.01513-20
  21. André Campaniço; Shrika G. Harjivan; Digby F. Warner; Rui Moreira; Francisca Lopes. "Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds". International Journal of Molecular Sciences 21 22 (2020): 8854-8854. https://doi.org/10.3390/ijms21228854.
    10.3390/ijms21228854
  22. Brito, H.; Marques, V.; Afonso, M.B.; Brown, D.G.; Börjesson, U.; Selmi, N.; Smith, D.M.; et al. "Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition". Cell Death Discovery 6 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079729058&partnerID=MN8TOARS.
    10.1038/s41420-020-0240-0
  23. de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS.
    10.1007/s12640-020-00229-6
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  135. Lavrado, J.; Paulo, A.; Gut, J.; Rosenthal, P.J.; Moreira, R.. "Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity". Bioorganic and Medicinal Chemistry Letters 18 4 (2008): 1378-1381. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949089316&partnerID=MN8TOARS.
    10.1016/j.bmcl.2008.01.015
  136. Santos, C.; Morais, J.; Gouveia, L.; De Clercq, E.; Pannecouque, C.; Nielsen, C.U.; Steffansen, B.; Moreira, R.; Gomes, P.. "Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity". ChemMedChem 3 6 (2008): 970-978. http://www.scopus.com/inward/record.url?eid=2-s2.0-48149103948&partnerID=MN8TOARS.
    10.1002/cmdc.200800012
  137. Vale, N.; Matos, J.; Moreira, R.; Gomes, P.. "Electrospray Ionization-Ion Trap Mass Spectrometry Study of PQAAPro and PQProAA Mimetic Derivatives of the Antimalarial Primaquine". Journal of the American Society for Mass Spectrometry 19 10 (2008): 1476-1490. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149103554&partnerID=MN8TOARS.
    10.1016/j.jasms.2008.06.019
  138. Vale, N.; Matos, J.; Gut, J.; Nogueira, F.; do Rosário, V.; Rosenthal, P.J.; Moreira, R.; Gomes, P.. "Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity". Bioorganic and Medicinal Chemistry Letters 18 14 (2008): 4150-4153. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149096687&partnerID=MN8TOARS.
    10.1016/j.bmcl.2008.05.076
  139. Martinelli, A.; Moreira, R.; Cravo, P.V.L.. "Malaria combination therapies: Advantages and shortcomings". Mini-Reviews in Medicinal Chemistry 8 3 (2008): 201-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-42449137053&partnerID=MN8TOARS.
    10.2174/138955708783744092
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  162. Clemente, A.; Domingos, A.; Grancho, A.P; Iley, J.; Moreira, R.; Neres, J.; Palma, N.; Santana, A.B; Valente, E.. "Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors". Bioorganic and Medicinal Chemistry Letters 11 8 (2001): 1065-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035938401&partnerID=MN8TOARS.
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  164. Iley, J.; Barroso, H.; Moreira, R.; Lopes, F.; Calheiros, T.. "Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: Chemical hydrolysis and anti-bacterial activity". Bioorganic and Medicinal Chemistry 8 7 (2000): 1629-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033936572&partnerID=MN8TOARS.
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Intellectual property

Patent
  1. Magalhães e Silva, Diogo; Moreira, Rui; Lopes, Francisca; Rodrigues, CMP; Marques, Vanda. 2023. "Drug delivery systems based on endoperoxides useful in diagnosis and therapy, and methods thereof".
    Pending
Provisional application for patent
  1. 2021. "1,2,4,5-TETRAOXANE COMPOUNDS, A DRUG DELIVERY SYSTEM BASED IN SAID COMPOUNDS USEFUL IN DIAGNOSES AND THERAPY, AND METHODS THEREOF".
    Protected

Other

Other output
  1. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable and Blood Brain Barrier Penetrant Proteolysis Targeting Chimera Degrader of Leucine Rich Repeat Kinase 2. 2022. Liu, X.; Kalogeropulou, A.F.; Domingos, S.; Makukhin, N.; Nirujogi, R.S.; Singh, F.; Shpiro, N.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136051007&partnerID=MN8TOARS.
    10.26434/chemrxiv-2022-4gzm0
  2. Half-sandwich cyclopentadienylruthenium(II) complexes: A new antimalarial chemotype. 2020. Milheiro, S.A.; Gonçalves, J.; Lopes, R.; Madureira, M.; Lobo, L.; Lopes, A.; Nogueira, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098906570&partnerID=MN8TOARS.
    10.26434/chemrxiv.12155178.v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/30 Novel Chemical Tools to Target Ferrous Iron-Dependent Biology EU-OPENSCREEN Webinar Series 2024
EU-OPENSCREEN (Webinar)
2023/10/24 Cases Studies in Antimalarial Drug Discovery Lecture for the ISF College of Pharmacy
ISF College of Pharmacy (On-Line, India)
2023/10/10 Endoperoxides as chemical tools to enable precision ferrous iron-dependent pharmacology DPhG Annual Meeting 2023
DPhG (Deutsche Pharmazeutische Gesellschaft) (TÜBINGEN, Germany)
2023/07/17 Iron Metabolism Dysregulation: a New Target for Precision Oncology XXI Meeting of the Paul Ehrlich Euro-PhD Network
Paul Ehrlich Euro-PhD Network (Thessaloniki, Greece)
2023/07/13 Design of Antimalarial Compounds Inspired by Natural Products III Bio.Natural- Bioactive Natural Products Research Conference
Bio.Natural (Lisbon, Portugal)
2023/07/10 New Chemical Tools to Target Therapeutically Relevant Serine Hydrolases Department Seminar
Université Côte d'Azur (Nice, France)
2023/05/10 Exploring new chemistries to finetune the selectivity of activity-base probes targeting serine hydrolases European Chemical Biology Symposium 2023
AstraZeneca (Gothenburg, Sweden)
2023/01/31 Strategies in Antimalarial Drug Discovery EU-OPENSCREEN Webinar Series 2023
EU-OPENSCREEN (On-Line)
2022/11/06 Designing chemical probes for serine hydrolases EU-OPENSCREEN - AUTUMN TRAINING SCHOOL 2022
EU-OPENSCREEN (On-Line)
2022/08/26 Targeting Iron Metabolism as a Novel Approach for Cancer Therapy VI Congress Turkish Association of Medicinal and Pharmaceutical Chemistry
Turkish Association of Medicinal and Pharmaceutical Chemistry (Istanbul, Turkey)
2022/06/22 Targeting Iron Metabolism Dysregulation for Precision Oncology XX Meeting of the Spanish Society of Medicinal Chemistry SEQT 2022
Spanish Society of Medicinal Chemistry (Santiago de Compostela, Spain)
2022/03/09 Medicinal Chemistry in Century, Quo Vadis Inaugural Lecture of 2022 Academic Year, Fiocruz Institute
Fiocruz Institute, on-line (on-line, Brazil)
2022/01/25 Targeting Iron Metabolism for Selective Drug Delivery XXVIII Summer School Professor Eliezer Barreiro in Medicinal Chemistry
On-Line
2021/08/25 From activity-based protein profiling to the optimization of covalent inhibitors targeting dipeptidyl peptidases GP2A 2021 - 29th Annual Conference, Group for the Promotion of Pharmaceutical chemistry in Academia
Group for the Promotion of Pharmaceutical chemistry in Academia (on-ine)
2021/04/30 Chemical Tools for Hypoxia- and Ferrous Iron-Dependent Pharmacology iMed Seminar Series
2021/04/09 Design of prodrugs for targeted therapy XIV Congresso Científico NEF/AAC
On-Line
2020/05/05 Discovery of Dipeptidyl Peptidases 8 and 9 covalent inhibitors using activity-based protein profiling and structure-based drug design António V. Xavier (AVX) seminars
ITQB-NOVA (Oeiras, Portugal)
2019/12 Discovery of new DPP8 and DPP9 inhibitors via activity-based protein profiling of serine hydrolases 4th Iberoamerican Symposium on Organic Chemistry (Sibeaqo-IV)
(Cayo Santa Maria, Cuba)
2019/10 Targeting Serine Hydrolases With Novel Activity-Based Probes University Seminar
University of Gottingen (Gottingen , Germany)
2019/01 Target identification using chemical biology Chemistry & Biology CrossTalks
University of Lisbon (Lisboa, Portugal)
2018/03 Boron in Medicinal Chemistry and Chemical Biology 245th American Chemical Society National Meeting
American Chemical Society (New Orleans, United States)
2017/12 Novel chemical approaches to target malaria parasites Seminar
University of Bonn (Bonn, Germany)
2017/11 Lead discovery for parasitic diseases 3rd Northern Postgraduate Symposium on Chemistry and Biotechnology
Postgraduate Programme on Chemistry and Biotechnology, Federal University of Alagoas (Maceió)
2017/09 From enzyme inhibitors to chemical probes: where Medicinal Chemistry and Chemical Biology meet Seminar
University of Porto (Porto, Portugal)
2017/07 Lead discovery for infectious diseases of the developing world: chemistry to unravel a black box 25th Meeting of the Portuguese Chemical Society
Portuguese Chemical Society (Lisboa, Portugal)
2017/06 Lead discovery for parasitic diseases 2nd Frontiers in Medicinal Chemistry Course
MedChemTrain PhD Programme (Penela, Portugal)
2016/11 Identification and optimization of a novel chemotype with antileishmanial and dual-stage antimalarial activities Drug Discovery and Development Centre (H3D) 2016 Symposium
Drug Discovery and Development Centre (H3D) 2016 Symposium (Worcester, South Africa)
2015/06 Fine Tuning of Heterocycles to Discover Chemical Tools for Tropical Diseases 7th Spanish-Portuguese-Japanese Organic Chemistry Symposium
Spanish Chemical Society (Seville, Spain)
2015/06 Drug design and screening: identifying new therapeutic targets 6th European Conference on Chemistry for Life Sciences, Protein School
EuChems Division of Life Sciences (Monte da Caparinca, Portugal)
2015/04 New medicines for malaria elimination 3rd National Meeting on Tropical Medicine
Portuguese Institute of Hygiene and Tropical Medicine (Lisboa, Portugal)
2015/02 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Sam Higginbottom Memorial International Lecture
Sam Higginbottom Institute of Agriculture, Technology and Science (Allahabad, India)
2015/02 A Chemogenomic Insight into the Discovery of Single and Dual-Stage Antimalarials 21st Indian Society of Chemists and Biologists International Conference (ISCBC-2015)
Indian Society of Chemists and Biologists (Lucknow, India)
2014/11 Chemogenomic Approaches to Single- and Dual-Stage Antimalarial Agents 7th Brazilian Symposium on Medicinal Chemistry (BrazMedChem2014)
(Campos do Jordão, Brazil)
2014/10 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST meeting
Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST action (Calvi, France)
2014/06 From Chemical Tools to Pre-Clinical Drug Discovery ChemULisboa
University of Lisbon (Lisboa, Portugal)
2014/05 Integrated Chemogenomic and In Silico Approaches to Develop Novel Antimalarial Lead Compounds Seminar
Institute of Molecular Medicine (Lis, Portugal)
2014/04 In Silico Discovery of Human Neutrophil Elastase Inhibitors for the Treatment of COPD 7th National Meeting of Biochemistry Students
(Monte da Caparica, Portugal)
2013/09 New Chemical Tools to Study the Biology of Malaria 10th National Meeting on Organic Chemistry
Portuguese Chemical Society Division of Organic Chemistry (Lisboa, Portugal)
2013/06 Targeting the liver and blood stages of malaria parasites with small and not-so-small molecules Seminar
University of California San Francisco, San Francisco General Hospital (San Francisco, United States)
2013/04 Chemistry in the Treatment of Malaria: From Bench to Bed Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)
2012/05 Medicinal Chemistry for New Antimalarial Agents ChemForum IST
Instituto Superior Tecnico, Technical University of Lisbon (Lisboa, Portugal)
2012/02 Novel Lead Compounds as Candidates for Single- and Multi-Stage Antimalarial Therapy Seminar
ETH Zurich (Zurich, Switzerland)
2011/11 The Pathway From Natural Products to Antimalarials 19th Portuguese-Galician Meeting of Chemistry
Colegio de Quimicos de Galicia and Portuguese Chemical Society (Pontevedra, Spain)
2011/06 Tuning the Reactivity of the beta-Lactam Scaffold as a Tool To Improve Inhibitory Potency Against Human Neutrophil Elastase 2nd Iberic Meeting on Medicinal Chemistry
(Porto, Portugal)
2011/06 Multi-target Strategies to Treat Malaria: a Challenging Task Seminar
University of Porto, Faculty of Sciences (Porto, Portugal)
2010/10 Rational Design of Bioactive Molecules: From the PC to the Bench and Vice-Versa. Novel Antimalarials Biopharmac 2010
University of Madeira (Funchal, Portugal)
2010/09 From ß-Lactams to 4-Oxo-ß-Lactams: Mechanistic Studies Towards Protease Inhibition 2nd Iberoamerican Symposium on Organic Chemistry (Sibeaqo-II)
(Santiago de Compostela, Spain)
2010/06 Malaria: the Long Pathway From Concepts to Drugs Seminar
University of Lisbon, Faculty of Sciences (Lisboa, Portugal)
2010/05 Targeting Exoerythrocytic, Erythrocytic and Sexual Stages of Malaria Parasites: a Challenging Task Annual International Conference of Medichem-2010 (ICM-2010)
(Beijing)
2009/06 New strategies in malaria chemotherapy: from recycling antimalarials to structure-base drug design Seminar
University of Evora (Lisboa, Portugal)
2008/12 Design and Synthesis of Human Leukocyte Elastase Inhibitors Based on the ß-Lactam Scaffold Seminar
University of Bonn (Bonn, Germany)
2006/12 Perspectivas de Desenvolvimento de Novos Fármacos para a Terapêutica da Malária VI Congresso Luso-Moçambicano de Medicina
2006/02 Recycling Antimalarials New 8-Amino- and 4-Aminoquinoline Analogues GSK Malaria Conference
GlaxoSmithKline (GSK) (Tres Cantos, Madrid, Spain)
2003/10 Lead Discovery Based on Reactivity Concepts COST Action D13 Conference on New Molecules Towards Human Health Care
COST Action D13 Conference on New Molecules Towards Human Health Care (Li, Portugal)
2003/02 Acyloxymethylation in drug and prodrug design. Scope and limitations Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/03/01 - Current Discovery of drug leads for SARS-CoV2 by Fragment-Based Drug Design
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/01/01 - Current Novel probes for imaging of tumor-associated cathepsins via Positron Emission Tomography (PET) and fluorescence microscopy
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/01 - Current New Chemical Tools to Target Necroptosis
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/01 - Current Synthetic valorization of natural compounds to new derivatives with potential pharmacological activity
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Targeting glioblastoma with two-photon-activable triazene prodrugs
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Extending the Akt-targeting pharmacological toolbox with PROteolysis TArgeting Chimeric molecules (PROTACs)
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Molecular photoswitches for targeting VEGFR2 and control angiogenesis
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Development of new drug leads for tuberculosis
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Expanding the Toolbox of Four-Membered Rings to Study Bacterial Serine Hydrolases
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Optimizing chemistry in flow with artificial intelligence
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Bio-triggered triazenes: a novel approach to release alkylating agents
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Computational analysis, de novo design, validation and target identification of necroptosis inhibitors
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Coimbra Departamento de Química, Portugal
2016 - 2020 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020 Pharmacological Modulators of Parkinson’s Disease-Associated Proteins
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020 Discovery of novel quinolone-based antimalarials using the Winterfeldt chemistry
Supervisor
 Medicina Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019 3-Oxo-ß-Sultams and 4-Oxo-ß-Lactams as Chemical Tools for Activity-based Protein Profiling of Serine Hydrolases
Supervisor of Luís Carvalho
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/09/01 - 2017 Medicinal Chemistry Approaches for Novel DNA Ligands
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2016 Medicinal Chemistry Approaches to Malarial Drug Discovery
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015 Design and Synthesis of Small Molecule Modulators of p53
Co-supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2015 Identification and Characterization by Electronspray Mass Spectrometry of Antimalarials that Inhibit the Mitochondrial Electron Transport Chain
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Synthesis and Computer-Assisted Design of Mitochondrial Electron Transport-Chain Inhibitors as Antimalarial Agents
Supervisor
 Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Peroxide-Based Hybrid and Prodrug Antimalarials to Deliver Cysteine Protease Inhibitors Into The Parasitic Food Vacuole
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Design, Synthesis, and Evaluation of Peptidyl Inhibitors for Clan CA and Clan CD Cysteine Proteases
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2011 Compostos híbridos da artemisinina. Direccionamento para as fases sanguínea e hepática do parasita da malária
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010 Amino Derivatives of Cryptolepine. Synthesis and In Vitro Studies with DNA and Haeme
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2010 N-Alkyl-ß-Lactams as Irreversible Inhibitors of Serine Proteases
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Irreversible Inhibitors of Serine Proteases Based on the beta-Lactam Scaffold as Potential Drug Candidates
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2003 - 2007 Potential Irreversible Inhibitors of Cysteine Proteases Based on Sultam and Naphthoquinone Scaffolds
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002 - 2007 Bsmoc Derivatives as Potential Cysteine Protease Inhibitors
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2001 - 2006 Ensaios de Degradação Acelerada do Nimesulide. 4-Imidazolidinonas Como Possíveis Pró-Fármacos da Primaquina
Supervisor
 Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1995 - 2000 Potenciais Pró-Fármacos de Sulfonamidas
Supervisor
 Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Desenvolvimento de Potenciais Pró-Fármacos de Ácidos Carboxílicos
Supervisor
 Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Reactividade de Ésteres Carboxamido-, Sulfonamido, e Imidometilicos de Penicilinas
Supervisor
 Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2008 - Current American Chemical Society
2000 - Current Ordem dos Farmacêuticos (Portuguese Board of Pharmacists)
1982/01/18 - Current Portuguese Chemical Society

Committee member

Activity description
Role 		Institution / Organization
2018/11/01 - Current Research Foundation Flanders (FWO): chair of the expert panel for pharmaceutical sciences
Other
 Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium
2000 - Current EMA: Expert in regulatory affairs for drug substances
Other
 European Medicines Agency, United Kingdom
1998 - Current INFARMED: Expert in regulatory affairs for drug substances
Other
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2024/01/01 - 2025/12/31 European Federation for Medicinal Chemistry and Chemical Biology (EFMC): Past-President
President / Vice-president
 European Federation for Medicinal Chemistry, Belgium
2021/01/01 - 2023/12/31 European Federation for Medicinal Chemistry and Chemical Biology (EFMC): President
President / Vice-president
 European Federation for Medicinal Chemistry, Belgium
2020/01/01 - 2020/12/31 European Federation for Medicinal Chemistry (EFMC): President Elect
President / Vice-president
 European Federation for Medicinal Chemistry, Belgium
2016/01/01 - 2019/12/31 European Federation for Medicinal Chemistry (EFMC): member of the Executive Committee
Member
 European Federation for Medicinal Chemistry, Belgium

Conference scientific committee

Conference name Conference host
2023/06/10 - 2033/06/13 ACSMEDI-EFMC Medicinal Chemistry Frontiers 2023 American Chemical Society | Division of Medicinal Chemistry
2023/09/03 - 2023/09/07 EFMC-ASMC 2023 IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry European Federation for Medicinal Chemistry
2022/09/04 - 2022/09/09 International Symposium on Medicinal Chemistry EFMC-ISMC 2022 European Federation for Medicinal Chemistry
2016/08/28 - 2016/09/01 International Symposium on Medicinal Chemistry EFMC-ISMC2016 European Federation for Medicinal Chemistry
2013/01 - 2014/09 International Symposium on Medicinal Chemistry EFMC-ISMC2014 European Federation for Medicinal Chemistry
2011/12 - 2012/09 International Symposium on Medicinal Chemistry EFMC-ISMC2012 European Federation for Medicinal Chemistry

Journal scientific committee

Journal title (ISSN) Publisher
2018 - 2020 MedChemComm (2040-2511) The Royal Society of Chemistry
Distinctions

Award

2009 Luso-American Collaborative Response Awards
Fundação Luso-Americana, Portugal
1985 Sociedade Lusitana Award
Ordem dos Farmaceuticos, Portugal

Title

2015 Honorary Life Fellow, Indian Society of Chemists and Biologists
Indian Society of Chemists and Biologists, India

Other distinction

2014 Chair of the International Simposium on Medicinal Chemistry (EFMC ISMC) 2014