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Identification

Personal identification

Full name
João Bessa

Citation names

  • Bessa, João

Author identifiers

Ciência ID
8C15-2942-459D
ORCID iD
0000-0001-6385-2452

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2008
Concluded
 Ciências Biológicas e Biomédicas (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"Novel insights in the Neurobiology of Depression: a role for neuroplasticity" (THESIS/DISSERTATION)
 Aprovado por Unanimidade
2001
Concluded
 Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 15 valores
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2017 - 2020 Associate Professor (University Teacher) Universidade do Minho Escola de Medicina, Portugal
2016 - 2018 Assistant Professor (University Teacher) Universidade do Minho Escola de Medicina, Portugal
2012 - 2013 Assistant Professor (University Teacher) Universidade do Minho Escola de Medicina, Portugal
2011 - 2011 Invited Assistant Professor (University Teacher) Universidade do Minho Escola de Medicina, Portugal
2004/01/01 - 2009/12/31 Invited Assistant (University Teacher) Universidade do Minho Escola de Medicina, Portugal

Others

Category
Host institution 		Employer
2017/06/02 - Current Neurosciences Research Domain Coordinator Laboratório Associado ICVS 3B's, Portugal
2009/03/01 - Current Assistant Psychiatrist Hospital de Braga, Portugal
2010/01/01 - 2011/10/18 Invited Professor Universidade do Minho Escola de Medicina, Portugal
2004/01/01 - 2008/12/31 Psychiatry Resident Hospital de Braga, Portugal
2003/01/01 - 2004/12/31 Anatomy Assistant Universidade do Minho Escola de Medicina, Portugal
2002/01/01 - 2003/12/31 General Hospital Resident Hospital de Braga, Portugal
Projects

Grant

Designation Funders
2017/06/01 - 2020/10/01 MEDPERSYST: Synaptic networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across the Lifespan
Grant. SAICTPAC/0010/2015
SAICTPAC/0010/2015
POCI-01-0145-FEDER-016428
Universidade do Minho, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade de Aveiro, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03 - 2013/02 Multimodal analysis of the neurobiology of depression
105180
Provided by PTCRIS: 105180
PTDC/SAU-NEU/105180/2008
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2020/01/01 - Current Promoting Mental Health During Pandemic - a digital platform for monitoring and intervention
110_596697345
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01/01 - Current Neuronal circuits of reward and aversion: where do endogenous opioids stand?
PTDC/MED-NEU/4804/2020
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2018/01/01 - Current MEDPERSYST - Redes sinápticas e abordagens compreensivas de medicina personalizada em doenças neurocomportamentais ao longo da vida
POCI-01-0145-FEDER-016428
Researcher
Ongoing
2023/03/01 - 2026/02/28 Hippocampal connectivity and behavioral performance in health and depression: where does adult astrogliogenesis stand?
2022.02201.PTDC
10.54499/2022.02201.PTDC
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2024/07/31 Genetic and functional maps of neuronal ensembles encoding natural rewards versus drugs of abuse
2022.01467.PTDC
10.54499/2022.01467.PTDC
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/10/25 - 2023/04/24 MiniSOG optogenetics: Harnessing the temporal and spatial control of neuron-astrocyte signaling to treat depression
EXPL/MED-NEU/0611/2021
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/02 - 2022/07/01 Terapia Multidisciplinar para Reparar Lesões Vertebro Medulares.
PTDC/BTM-MAT/29968/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2020 Metabolic dysfunctions associated with the pharmacological treatment of schizophrenia
H2020-MSCA-ITN-2016
Researcher
Ongoing
2016 - 2020 A novel multimodal predictive approach of the effects of antidepressants in the recovery, remission and relapse of depression.
PTDC/DTP-PIC/6936/2014
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2016 - 2020 A novel multimodal predictive approach of the effects of antidepressants in the recovery, remission and relapse of depression.
PTDC/DTP-PIC/6936/2014
 Fundação para a Ciência e a Tecnologia
2016/07/01 - 2019/11/30 Farmacologia e Células Estaminais para Reparar as Lesões da Medula Espinhal: Será o Todo Maior que a Soma das suas Partes?
PTDC/DTP-FTO/5109/2014
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/08/01 - 2015/01/31 Mecanismos comuns às alterações de humor e disfunção cognitiva induzidos pelo stress - da depressão à doença de alzheimer.
PTDC/SAU-NMC/113934/2009
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 23 - 2011-2012
PEst-OE/EQB/LA0023/2011
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal

Universidade do Algarve, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal

Fundação Gaspar Frutuoso, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade dos Açores, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2011 Mechanistic links between stress-induced mood and cognitive dysfunction - the path from depression to alzheimer's disease.
PTDC/SAU-NMC/113934/2009
Researcher
Laboratório Associado ICVS 3B's, Portugal
2008 - 2010 Alterações do comportamento emocional e cognitivo em estados de dor crónica: caracterização espaço-temporal de alterações plásticas associadas no SNC
PTDC/SAU-NEU/108557/2008
Researcher
Laboratório Associado ICVS 3B's, Portugal
2008 - 2010 Neudesin - characterization of a novel neurotrophic factor
PTDC/SAU-OSM/104475/2008
Researcher
2007 - 2009 New approaches in multiple sclerosis diagnosis: the role of the choroid plexus
PIC/IC/83231/2007
Researcher
Laboratório Associado ICVS 3B's, Portugal
2006 - 2009 New perspectives in the neurobiology of depression: beyond the “neurochemical hypothesis
PTDC/SAU-NEU/72699/2006
Researcher
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2009 New perspectives in the neurobiology of depression: beyond the ¿neurochemical hypothesis
PTDC/SAU-NEU/72699/2006
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Bessa, João. "Psicofarmacologia na depressão". In Manual de Psicofarmacologia Clínica na Prática Clínica. Portugal: Lidel, 2018.
    Published
  2. Bessa, João. "Neurogenesis". In Encyclopedia of Psychopharmacology, Part 14, Pages 851-854., 851-854. 2010.
    Published
Journal article
  1. Afonso Gouveia; Filipa Martins; Pedro Trindade; Gustavo Jesus; João M. Bessa; Maria João Heitor; Luís Câmara Pestana; et al. "Nomenclatura Baseada na Neurociência para Psicofármacos: Quatro Razões para a Usar e Manter em Portugal". Acta Médica Portuguesa (2024): https://doi.org/10.20344/amp.20267.
    10.20344/amp.20267
  2. "Suicidal ideation is associated with reduced functional connectivity and white matter integrity in drug-naïve patients with Major Depression". Frontiers in Psychiatry (2022): https://www.frontiersin.org/articles/10.3389/fpsyt.2022.838111/abstract.
    Open access • Accepted • 10.3389/fpsyt.2022.838111
  3. Mariz, José; Pires, Olga; Lopes, Amândia; Bessa, João; Correia, Luís; Morgado, Pedro; Teixeira, Jorge; Sousa, Nuno; Correia Santos, Nadine. "The Confusion Assessment Method for Intensive Care Unit: A Large Cohort Validation Study in the Emergency Department of a Tertiary Hospital". (2022): https://doi.org/10.24950/rspmi.682.
    https://doi.org/10.24950/rspmi.682
  4. Mateus-Pinheiro, António; Patrício, Patrícia; Alves, Nuno Dinis; Martins-Macedo, Joana; Caetano, Inês; Silveira-Rosa, Tiago; Araújo, Bruna; et al. "Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits". Molecular Psychiatry (2021): http://dx.doi.org/10.1038/s41380-021-01287-8.
    10.1038/s41380-021-01287-8
  5. Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhães, Ricardo; Marques, Paulo; et al. "The Association of Metabolic Dysfunction and Mood Across Lifespan Interacts With the Default Mode Network Functional Connectivity". Frontiers in Aging Neuroscience 13 (2021): http://dx.doi.org/10.3389/fnagi.2021.618623.
    Published • 10.3389/fnagi.2021.618623
  6. Vieira, Rita; Coelho, Ana; Reis, Joana; Portugal-Nunes, Carlos; Magalhães, Ricardo; Ferreira, Sónia; Moreira, Pedro Silva; Sousa, Nuno; Bessa, João M.. "White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression". Frontiers in Behavioral Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnbeh.2021.693109.
    Published • 10.3389/fnbeh.2021.693109
  7. Bessa, João. "The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies". Neuropsychology Review 30 3 (2020): 287-309. http://dx.doi.org/10.1007/s11065-020-09441-9.
    10.1007/s11065-020-09441-9
  8. Bessa, João. "miR-409 and miR-411 Modulation in the Adult Brain of a Rat Model of Depression and After Fluoxetine Treatment". Frontiers in Behavioral Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnbeh.2020.00136.
    10.3389/fnbeh.2020.00136
  9. Bessa, João. "Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study". Stress (2020): 1-6. http://dx.doi.org/10.1080/10253890.2020.1781083.
    10.1080/10253890.2020.1781083
  10. Portugal-Nunes, C.; Castanho, T.C.; Moreira, P.S.; Magalhães, R.; Marques, P.; Costa, P.; Palha, J.A.; et al. "The moderator effect of age in the association between mood and adiposity in the elderly is specific for the subcutaneous adipose compartment: An MRI study". International Journal of Geriatric Psychiatry 35 1 (2020): 113-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074915236&partnerID=MN8TOARS.
    10.1002/gps.5226
  11. Thompson, S.L.; Welch, A.C.; Ho, E.V.; Bessa, J.M.; Portugal-Nunes, C.; Morais, M.; Young, J.W.; Knowles, J.A.; Dulawa, S.C.. "Btbd3 expression regulates compulsive-like and exploratory behaviors in mice". Translational Psychiatry 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071976323&partnerID=MN8TOARS.
    10.1038/s41398-019-0558-7
  12. Machado-Santos, A.R.; Alves, N.D.; Araújo, B.; Correia, J.S.; Patrício, P.; Mateus-Pinheiro, A.; Loureiro-Campos, E.; et al. "Astrocytic plasticity at the dorsal dentate gyrus on an animal model of recurrent depression". Neuroscience (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075879686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2019.10.032
  13. Alves, N.D.; Patrício, P.; Correia, J.S.; Mateus-Pinheiro, A.; Machado-Santos, A.R.; Loureiro-Campos, E.; Morais, M.; et al. "Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus". Brain Structure and Function 223 1 (2018): 415-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028750066&partnerID=MN8TOARS.
    10.1007/s00429-017-1490-3
  14. Ferreira, A.C.; Sousa, N.; Bessa, J.M.; Sousa, J.C.; Marques, F.. "Metabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress". Neuroscience and Biobehavioral Reviews 95 (2018): 73-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054364759&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2018.09.014
  15. Rodrigues-Amorim, D.; Rivera-Baltanás, T.; Bessa, J.; Sousa, N.; Vallejo-Curto, M.D.C.; Rodríguez-Jamardo, C.; de las Heras, M.E.; et al. "The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis". Journal of Psychiatric Research 106 (2018): 43-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054003084&partnerID=MN8TOARS.
    10.1016/j.jpsychires.2018.09.007
  16. Pêgo, J.M.; Cerqueira, J.J.; Bessa, J.; Pereira, V.H.; Gomes, S.; Mariz, J.; Sousa, R.; Morgado, P.; Sousa, N.. "Fifteen years of experience from a medical school’ clinical skills laboratory,Quinze anos de experiência do laboratório de aptidões clínicas de uma escola médica". Acta Medica Portuguesa 30 2 (2017): 85-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014082740&partnerID=MN8TOARS.
    10.20344/amp.8408
  17. Morais, M.; Patrício, P.; Mateus-Pinheiro, A.; Alves, N.D.; MacHado-Santos, A.R.; Correia, J.S.; Pereira, J.; et al. "The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression". Translational Psychiatry 7 6 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020410481&partnerID=MN8TOARS.
    10.1038/tp.2017.120
  18. Dioli, C.; Patrício, P.; Trindade, R.; Pinto, L.G.; Silva, J.M.; Morais, M.; Ferreiro, E.; et al. "Tau-dependent suppression of adult neurogenesis in the stressed hippocampus". Molecular Psychiatry 22 8 (2017): 1110-1118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026899195&partnerID=MN8TOARS.
    10.1038/mp.2017.103
  19. Alves, N.D.; Correia, J.S.; Patrício, P.; Mateus-Pinheiro, A.; Machado-Santos, A.R.; Loureiro-Campos, E.; Morais, M.; et al. "Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression". Translational psychiatry 7 3 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85033732587&partnerID=MN8TOARS.
    10.1038/tp.2017.29
  20. Pêgo, José Miguel; Cerqueira, João José; Bessa, João; Pereira, Vitor Hugo; Gomes, Sara; Mariz, José; Sousa, Rita; Morgado, Pedro; Sousa, Nuno. "Fifteen Years of Experience from a Medical School¿ Clinical Skills Laboratory". (2017): https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8408.
  21. Teixeira-Castro, A.; Jalles, A.; Esteves, S.; Kang, S.; Da Silva Santos, L.; Silva-Fernandes, A.; Neto, M.F.; et al. "Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease". Brain 138 11 (2015): 3221-3237. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947806720&partnerID=MN8TOARS.
    10.1093/brain/awv262
  22. Patricio, Patricia; Mateus-Pinheiro, Antonio; Irmler, Martin; Alves, Nuno D.; Machado-Santos, Ana R.; Morais, Monica; Correia, Joana S.; et al. "Differential and Converging Molecular Mechanisms of Antidepressants' Action in the Hippocampal Dentate Gyrus". Neuropsychopharmacology 40 2 (2015): 338-349. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346147800010&KeyUID=WOS:000346147800010.
    10.1038/npp.2014.176
  23. Morais, Monica; Santos, Paulo A. R.; Mateus-Pinheiro, Antonio; Patricio, Patricia; Pinto, Luisa; Sousa, Nuno; Pedroso, Pedro; et al. "The effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition". Journal of Psychopharmacology 28 12 (2014): 1178-1183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345221900011&KeyUID=WOS:000345221900011.
    10.1177/0269881114553646
  24. Opal, M. D.; Klenotich, S. J.; Morais, M.; Bessa, J.; Winkle, J.; Doukas, D.; Kay, L. J.; Sousa, N.; Dulawa, S. C.. "Serotonin 2C receptor antagonists induce fast-onset antidepressant effects (vol 19, pg 1150, 2014)". Molecular Psychiatry 19 10 (2014): 1150-1150. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000343661700015&KeyUID=WOS:000343661700015.
    10.1038/mp.2013.164
  25. Opal, M.D.; Klenotich, S.C.; Morais, M.; Bessa, J.; Winkle, J.; Doukas, D.; Kay, L.J.; Sousa, N.; Dulawa, S.M.. "Serotonin 2C receptor antagonists induce fast-onset antidepressant effects". Molecular Psychiatry 19 10 (2014): 1106-1114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922771522&partnerID=MN8TOARS.
    10.1038/mp.2013.144
  26. Mateus-Pinheiro, Antonio; Patricio, Patricia; Alves, Nuno D.; Machado-Santos, Ana R.; Morais, Monica; Bessa, Joao M.; Sousa, Nuno; Pinto, Luisa. "The Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents". Frontiers in Behavioral Neuroscience 8 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000332470800001&KeyUID=WOS:000332470800001.
    10.3389/fnbeh.2014.00074
  27. Morgado, P.; Freitas, D.; Bessa, J.M.; Sousa, N.; Cerqueira, J.J.. "Perceived stress in obsessive-compulsive disorder is related with obsessive but not compulsive symptoms". Frontiers in Psychiatry 4 APR (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84877697236&partnerID=MN8TOARS.
    10.3389/fpsyt.2013.00021
  28. Mateus-Pinheiro, A.; Patrício, P.; Bessa, J.M.; Sousa, N.; Pinto, L.. "Cell genesis and dendritic plasticity: A neuroplastic pas de deux in the onset and remission from depression". Molecular Psychiatry 18 7 (2013): 748-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879409713&partnerID=MN8TOARS.
    10.1038/mp.2013.56
  29. Bessa, J.M.; Morais, M.; Marques, F.; Pinto, L.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens". Translational Psychiatry 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879969155&partnerID=MN8TOARS.
    10.1038/tp.2013.39
  30. Palha JA; Santos NC; Marques F; Sousa J; Bessa J; Miguelote R; Sousa N; Belmonte-de-Abreu P. "Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia.". (2012): http://europepmc.org/abstract/med/22891052.
    10.3389/fncel.2012.00031
  31. Pinto, L.; Mateus-Pinheiro, A.; Morais, M.; Bessa, J.M.; Sousa, N.. "Immuno-golgi as a tool for analyzing neuronal 3D-dendritic structure in phenotypically characterized neurons". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858052488&partnerID=MN8TOARS.
    10.1371/journal.pone.0033114
  32. Bessa, J.M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, J.J.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling". Molecular Psychiatry 14 8 (2009): 764-773. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349216843&partnerID=MN8TOARS.
    10.1038/mp.2008.119
  33. Bessa, J.M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, J.J.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "Hippocampal neurogenesis induced by antidepressant drugs: An epiphenomenon in their mood-improving actions". Molecular Psychiatry 14 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67651149865&partnerID=MN8TOARS.
    10.1038/mp.2009.75
  34. Bessa, J.M.; Mesquita, A.R.; Oliveira, M.; Pêgo, J.M.; Cerqueira, J.J.; Palha, J.A.; Almeida, O.F.X.; Sousa, N.. "A trans-dimensional approach to the behavioral aspects of depression". Frontiers in Behavioral Neuroscience 3 JAN (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70549106185&partnerID=MN8TOARS.
    10.3389/neuro.08.001.2009
  35. Gonçalves, L.; Silva, R.; Pinto-Ribeiro, F.; Pêgo, J.M.; Bessa, J.M.; Pertovaara, A.; Sousa, N.; Almeida, A.. "Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat". Experimental Neurology 213 1 (2008): 48-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349109655&partnerID=MN8TOARS.
    10.1016/j.expneurol.2008.04.043
  36. Silva, R.; Mesquita, A.R.; Bessa, J.; Sousa, J.C.; Sotiropoulos, I.; Leão, P.; Almeida, O.F.X.; Sousa, N.. "Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3ß". Neuroscience 152 3 (2008): 656-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949125640&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2007.12.026
  37. Almeida, O. F.; Yu, S.; Bessa, J.; Silva, R.; Holsboer, F.; Sousa, N.. "Stress in the life of a neuron". International Journal of Neuropsychopharmacology 11 (2008): 41-41. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000258855500173&KeyUID=WOS:000258855500173.
  38. Oliveira, M.; Bessa, J.M.; Mesquita, A.; Tavares, H.; Carvalho, A.; Silva, R.; Pêgo, J.M.; et al. "Induction of a Hyperanxious State by Antenatal Dexamethasone: A Case for Less Detrimental Natural Corticosteroids". Biological Psychiatry 59 9 (2006): 844-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646092781&partnerID=MN8TOARS.
    10.1016/j.biopsych.2005.08.020
  39. Cerqueira, J.J.; Pêgo, J.M.; Taipa, R.; Bessa, J.M.; Almeida, O.F.X.; Sousa, N.. "Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors". Journal of Neuroscience 25 34 (2005): 7792-7800. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944508570&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1598-05.2005
  40. Bessa, J.M.; Oliveira, M.; Cerqueira, J.J.; Almeida, O.F.X.; Sousa, N.. "Age-related qualitative shift in emotional behaviour: Paradoxical findings after re-exposure of rats in the elevated-plus maze". Behavioural Brain Research 162 1 (2005): 135-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-19444366293&partnerID=MN8TOARS.
    10.1016/j.bbr.2005.03.005

Intellectual property

Patent
  1. Bessa, João. 2015. "Method for labelling neurons and its applications". Portugal.
    Granted/Issued

Other

Other output
  1. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.. 2013. Mateus-Pinheiro, A.; Pinto, L.; Bessa, J.M.; Morais, M.; Alves, N.D.; Monteiro, S.; Patrício, P.; Almeida, O.F.; Sousa, N.. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879414589&partnerID=MN8TOARS.
    10.1038/tp.2012.141
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 The importance of biological factors in treatment resistant Depression Congresso Mundial de Psiquiatria
World Psychiatry Association (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/01/01 - Current Multidimensional and predictive approach of suicide in Major Depression: From suicidal ideation to action
Supervisor of Ana Rita Vieira
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01/01 - Current Metabolic dysfunctions associated with the pharmacological treatment of Schizophrenia
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01/01 - 2021/01/01 fMRI guided EEG-neurofeedback as a possible tool for treatment-resistant depression
Supervisor of Joana Reis
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/01/01 - 2020/01/01 Depression and insulin resistance: exploring the brain-metabolism crosstalk
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01/01 - 2018/12/01 Neural correlates of emotional processing as a biomarker of treatment response in Major Depressive Disorder: a functional fMRI approach
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/01/01 - 2016/12/12 The role of Tau protein in the stress-induced changes in adult hippocampus neurogenesis
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/01/01 - 2016/12/01 The effects of antipsychotics in astrocytic plasticity and social behaviour in an animal model of schizophrenia
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/01/01 - 2016/01/01 New insights on the interplay between psychopharmacology and neuroplasticity in psychiatric disorders
Supervisor of Mónica Morais
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Association member

Society Organization name Role
2023/03/10 - 2026/03/10 Presidente da Sociedade Portuguesa de Psiquiatria e Saúde Mental (SPPSM)
2020/01/30 - 2023/01/30 Presidente Eleito da Sociedade Portuguesa de Psiquiatria e Saúde Mental Presidente Eleito
2013/01/01 - 2017/01/01 European College of Neuropsychopharmacology (ECNP) Ambassador in Portugal

Committee member

Activity description
Role 		Institution / Organization
2020/04/01 - 2020/06/01 Membro do Painel de Avaliação do Programa DOCTORES4COVID da FCT
Member
 Fundação para a Ciência e a Tecnologia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/06/01 - 2019/06/06 Advanced Course in Applied Clinical Psychopharmacology Advanced Course in Applied Clinical Psychopharmacology (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/04/01 - 2019/04/04 iPsiquiatria - Introdução à Psiquiatria iPsiquiatria - Introdução à Psiquiatria (Especialização pós-licenciatura) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019/01/01 - Current Co- Coordenador da Comissão de Avaliação dos Relatórios Científicos Finais de Projetos IC&DT 2019-2022| CA Neurociências
Member
 Fundação para a Ciência e a Tecnologia, Portugal
2020/01/01 - 2020/02/01 Membro do Júri do Prémio BIAL de Medicina Clínica 2020
Evaluator
 Fundação Bial, Portugal
2019/01/01 - 2019/01/02 Membro do Júri das Bolsas de Doutoramento em Medicina José de Mello Saúde
Evaluator
 Grupo José de Mello, Portugal
Distinctions

Other distinction

2013 Young Entrepreneurs Prize
2011 1st Award - SpinUM Business Ideas Contest 2011
2011 SpinUM Young Entrepreneurs Prize 2011
2009 Best Paper Award 2009
2007 Best Poster Award
2007 Grunenthal Pain Prize 2007 - Basic Research
Fundação Grünenthal, Portugal
2006 Best Poster Award
2004 Best Poster Award