???global.info.a_carregar???
Identification

Personal identification

Full name
Ana Filipa Sobral

Citation names

  • Sobral, AF
  • Sobral, A.F.

Author identifiers

Ciência ID
8D11-2E0D-4537
ORCID iD
0000-0003-3674-3116
Scopus Author Id
57209069887

Email addresses

  • ana.sobral@iucs.cespu.pt (Professional)
  • filipasobral.phd@outlook.com (Personal)
  • filipasobral.phd@outlook.com (Personal)

Addresses

  • Instituto Universitário de Ciências da Saúde (IUCS), Rua Central da Gandra 1317, 4585-116, Gandra, Paredes, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/01/01 - 2022/06/01
Concluded
 Biomedical Sciences (Doutoramento)
Major in Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Functionalities and interplay of actin-filament crosslinkers in vivo." (THESIS/DISSERTATION)
2013/09/01 - 2015/09
Concluded
 Cell and Molecular Biology (Mestrado)
Major in Área de especialização: Biologia Molecular e Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"New steroidal aromatase inhibitors: biological effects in hormone- dependent breast cancer cell models" (THESIS/DISSERTATION)
 18 valores
2010/09 - 2013/07
Concluded
 Bioanalytical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2024/01 - Current Researcher (Research) Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2022/01/17 - 2022/09/29 Research Assistant (Research) FairJourney Biologics SA, Portugal
2017/04/01 - 2022/01/15 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/02/15 - 2017/03/31 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/09/01 - 2015/09/22 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
2014/03/10 - 2014/04/04 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/10/14 - 2013/11/11 Research Trainee (Research) Centro de Sangue e da Transplantação de Coimbra, Portugal
2013/07/01 - 2013/07/31 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/01/10 - Current Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2021/06/01 - 2021/07/31 Functionalities and interplays of Actin-Filament Crosslinkers in vivo
COVID/BD/151810/2021
10.54499/COVID/BD/151810/2021
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/04/01 - 2021/05/31 Functionalities and interplays of Actin-Filament Crosslinkers in vivo
SFRH/BD/121874/2016
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
PhD Student Fellow
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Ana Filipa Sobral; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "CRISPR-Cas technology in forensic investigations: Principles, applications, and ethical considerations". Forensic Science International: Genetics (2025): http://dx.doi.org/10.1016/j.fsigen.2024.103163.
    10.1016/j.fsigen.2024.103163
  2. Renata Silva; Ana Filipa Sobral; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "The Link Between Paraquat and Demyelination: A Review of Current Evidence". Antioxidants (2024): https://doi.org/10.3390/antiox13111354.
    10.3390/antiox13111354
  3. Ana Filipa Sobral; Andrea da Cunha; Vera Silva; Eva Gil Martins; Renata Silva; Daniel José Barbosa. "Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration". International Journal of Molecular Sciences (2024): https://www.mdpi.com/1422-0067/25/17/9339.
    10.3390/ijms25179339
  4. AM Silva; Fung-Yi, Chan; Michael Norman; Esther Zanin; Ana Filipa Sobral; Reto Gassmann; JM Belmonte; Ana Xavier de Carvalho. "ß-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis.". The Journal of cell biology (2022): https://doi.org/10.1083/jcb.202202024.
    10.1083/jcb.202202024
  5. Ana Filipa Sobral. "Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis". Current Biology 31 24 (2021): 5415-5428.e10. http://dx.doi.org/10.1016/j.cub.2021.09.055.
    10.1016/j.cub.2021.09.055
  6. Leite, J.; Chan, F.-Y.; Osório, D.S.; Saramago, J.; Sobral, A.F.; Silva, A.M.; Gassmann, R.; Carvalho, A.X.. "Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092498962&partnerID=MN8TOARS.
    10.3389/fcell.2020.573393
  7. Osório, D.S.; Chan, F.-Y.; Saramago, J.; Leite, J.; Silva, A.M.; Sobral, A.F.; Gassmann, R.; Carvalho, A.X.. "Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans". Development (Cambridge, England) 146 21 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074964249&partnerID=MN8TOARS.
    10.1242/dev.179150
  8. Leite, J.; Osorio, D.S.; Sobral, A.F.; Silva, A.M.; Carvalho, A.X.. "Network contractility during cytokinesis—from molecular to global views". Biomolecules 9 5 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066454203&partnerID=MN8TOARS.
    10.3390/biom9050194
  9. Amaral, C.; Varela, C.L.; Maurício, J.; Sobral, A.F.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.J.; Correia-da-Silva, G.; Teixeira, N.. "Anti-tumor efficacy of new 7a-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells". Journal of Steroid Biochemistry and Molecular Biology 171 (2017): 218-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017457908&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2017.04.002
  10. Sobral, A.F.; Amaral, C.; Correia-da-Silva, G.; Teixeira, N.. "Unravelling exemestane: From biology to clinical prospects". Journal of Steroid Biochemistry and Molecular Biology 163 (2016): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962441168&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2016.03.019
Journal issue
  1. Sobral, Ana Filipa; Barbosa, DJ. "Molecular motors in neuronal homeostasis and neurodegeneration". Brain Sciences (2025): https://www.mdpi.com/journal/brainsci/special_issues/M6L3X70WW5.
    In press
Thesis / Dissertation
  1. "Functionalities and interplay of actin-filament crosslinkers in vivo". PhD, 2022. https://hdl.handle.net/10216/141519.
  2. Sobral, Ana Filipa Fernandes Ferreira. "New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models". Master, 2015. http://hdl.handle.net/10316/32980.

Other

Other output
  1. Flow-independent accumulation of motor-competent non-muscle myosin II in the contractile ring is essential for cytokinesis. 2018. Osorio, D.S.; Chan, F.Y.; Saramago, J.; Leite, J.; Silva, A.M.; Sobral, A.F.; Gassmann, R.; Carvalho, A.X.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095546808&partnerID=MN8TOARS.
    10.1101/333286
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/10/01 - Current Impact of synthetic cathinones on C. elegans development, locomotion and reproductive behaviours, and lifespan
Supervisor
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2024/09/01 - Current Combined consumption of ethanol and lorazepam: toxic effects in the C. elegans animal model
Supervisor
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2024/09/01 - Current Toxicology of ketamine in the C. elegans animal model
Co-supervisor
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2024/10/16 - 2024/10/16 Member of the Scientific Commitee of the VI PhD Day IUCS 2024
Member
 Instituto Universitário de Ciências da Saúde, Portugal

Other jury / evaluation

Activity description Institution / Organization
2024/07/24 - 2024/07/24 Principal Juri of the Investigation Project Report defense of the student Daniela Alexandra Coelho Maia for the Curricular Unit Methodoly and Project in Forensic Investigation, from the Bachelor Degree in Forensic Sciences Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
2022/07/01 - 2022/07/01 Principal Juri of the Internship Report Defense of the student Inês Lima Carvalho of the Bachelor Degree in Biochemistry, at Instituto de Ciências Biomédicas Abel Salazar of University of Porto Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2011 Prémio 3% dos Melhores Estudantes
Universidade de Coimbra, Portugal

Other distinction

2017 Bolsa de Doutoramento FCT
Fundação para a Ciência e a Tecnologia, Portugal
2016 Bolsa de Investigação de Mestre (BIM)
European Research Council, Belgium

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Biologia Molecular e Celular, Portugal
2003 Menção Honrosa Melhores Estudantes