Rui Miguel Oliveira da Costa (8D18-658D-0961)

Curriculum Vitae

Rui Miguel Oliveira da Costa

Rui Miguel Oliveira da Costa (RC) graduated in Biology in 2006 and completed the PhD in Cell Biology in 2011/12/06 by the Faculty of Science and Technology of the University of Coimbra, with highest honors. Since 2019, RC secured a position at the Centro de Inovação em Biomedicina e Biotecnologia (CIBB), and leads his own subgroup within the Neurotrophic Signaling group. In the last 5 years RC have was awarded with research funding and participated in funded research projects, presented his work in national and international meetings and published 8 articles in journals and 1 book chapter (4 as first or senior author) and has 2 more articles in submission stage, denoting his successful scientific production. Of these papers some were in high ranked journals. In total, RC published 18 articles in journals (8 as 1st or senior author) and 2 book chapters in the Neuroscience field. RC is Senior and/or first author of his most prominent original papers published in Top percentile journals (1%-10%) in the areas of Cell Biology and Aging (e.g. Cell Reports, WIREs RNA, Aging Cell, Neurobiology of Aging,). His work had 1265 citations (625, since 2018), and an h-index of 15 (source: WOS, Google Scholar). His scientific contributions were in the areas of Medical and Health Sciences with emphasis on Neurosciences, Biological Sciences with emphasis on Cell Biology and synaptic biology. RC participates and/or participated as Principal investigator in 2 projects (work was published in Cell Reports journal as corresponding author), as PhD Student Fellow in 1 project(s), as Post-doc Fellow in 1 project(s), as Research Technician Fellow in 1 project(s) and as Researcher in 10 project(s). In his professional activities interacted with 168 collaborator(s) co-authorship of scientific papers. RC established several national and international collaborations, and acquired large scientific expertise by working at 5 different labs (Portugal, USA & Italy), in AD and axonal biology fields, mastering a wide range of methodologies (e.g. microscopy, molecular biology, neuronal cultures, cell lines, in vivo studies, in utero electroporation, MCAo and human sample processing). In Particular RC had advanced training at one of the most respected labs in AD field (Klein's Lab), at Northwestern Univ. (USA) and at the lab of L. Cancedda (Italy). RC completed a FELASA cat C course in Laboratory Animal Science (2010). RC has Organized 2 event (conceived and lectured science courses and I has been involved in outreach science awareness activities); Participated in 34 event(s); Lectured in BSc, MSc and PhD programs at the Universities of Coimbra and Algarve and formally supervised/co-supervised 7 MSc students (Portuguese and foreign) and several undergraduate students. Mentored/ tutored several PhD and MSc students during their laboratory internships (>13 in total); Has been Committee member in several theses defenses (8 MSc thesis, as main opponent) at the University of Coimbra and University of Aveiro; Presently, RC supervises 1 PhD student (UI/BD/154202/2022), 2 MSc students and 1 BSc student. Has received 7 awards and/or honors, including a scientific incentive grant (2022), PhD fellowship and Post-Doctoral fellowship in a highly competitive program (FCT 2006 and 2013, respectively); RC is ad hoc reviewer for several scientific journals (including Aging cell journal). In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Alzheimer's disease; ER Stress; Mitochondria; NMDA receptors; Cell Culture; Cell Biology; Axonal development; Basic biology; Synaptogenesis; Neuronal development; Axonal degeneration; Synapse; Axonal growth; Ribosomes; Ubiquitin protein system; axonal biology; Synapse biology RC benefited from 2 paternity leave (2017, 2023).

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Identification

Personal identification

Full name: Rui Miguel Oliveira da Costa
Date of birth: 1983/06/17
Gender: Male

Citation names

Costa RO
Rui O Costa
Costa, Rui

Author identifiers

Ciência ID: 8D18-658D-0961
ORCID iD: 0000-0002-2652-7500
Google Scholar ID: gJoLzOwAAAAJ
Researcher Id: K-6898-2013
Scopus Author Id: 36486010000

Email addresses

ruiocosta@gmail.com (Professional)
rui.costa@cnc.uc.pt (Professional)

Telephones

Mobile phone

(+351) 965138876 (Personal)

Telephone

(+351) 239820190 (Professional)
(+351) 304502914 (Professional)

Addresses

Centro de NeuroCiências e Biologia Celular. Rua Larga, Faculdade de Medicina, Polo I, 2ºpiso, Lab 206a, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)
Rua Do Brasil Nº351 2ºDir, 3030-175, Coimbra, Coimbra, Portugal (Personal)

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110#34 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Natural sciences - Biological Sciences - Cell Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Italian	Upper intermediate (B2)	Upper intermediate (B2)	Beginner (A1)	Advanced (C1)	Upper intermediate (B2)
French	Intermediate (B1)	Upper intermediate (B2)	Beginner (A1)	Upper intermediate (B2)	Elementary (A2)
Japanese	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)
Spanish; Castilian	Beginner (A1)	Upper intermediate (B2)	Beginner (A1)	Upper intermediate (B2)	Elementary (A2)

Education

	Degree	Classification
2006/10/01 - 2011/12/06 Concluded	Doutoramento em Biologia - especialidade em Biologia Celular (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors" (THESIS/DISSERTATION)	Aprovado com Distinção e Louvor, por Unanimidade.
2010/04/19 - 2010/04/30 Concluded	Course on Laboratorial Animal Science (LAS) course - FELASA cat C (Pós-Graduação) CNC.IBILI, Portugal	Approved
2001/09 - 2006/07/05 Concluded	Biologia (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide " (THESIS/DISSERTATION)	15/20 (15.4 valores)

Affiliation

Science

	Category Host institution	Employer
2019/02/05 - Current	Contracted Researcher (Research)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/01/01 - 2019/02/04	Postdoc (Research)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2015/09 - 2016/01	Visiting Researcher (Research)	Istituto Italiano di Tecnologia, Italy
	Istituto Italiano di Tecnologia, Italy
2006/10/01 - 2011/12/06	Researcher (Research)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2008/06 - 2009/03	Visiting Researcher (Research)	Northwestern University - Chicago, United States
	Northwestern University - Chicago, United States

Others

	Category Host institution	Employer
2011/01 - 2011/09	Research Technician	CNC.IBILI, Portugal

Projects

Grant

	Designation	Funders
2021/07/01 - Current	Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization PTDC/BIA-CEL/2286/2020 Researcher	Fundação para a Ciência e a Tecnologia
2019/02/05 - Current	BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke. PTDC/CTM-NAN/3547/2014. Researcher
2019 - Current	Strategic Plan CNC.IBILI UID/ NEU/04539/2019 Researcher Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia
2022 - 2023	The RNA-binding protein hnRNPH2: a novel player in epileptogenesis n.a Principal investigator Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Ongoing
2013/01/01 - 2019/02	Pos-Doc project: Mechanisms underlying ribosomal regulation in axonal development SFRH/BPD/84593/2012 Post-doc Fellow CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07 - 2014/12	Mechanism underlying ribosomal regulation in axonal development grant.Provided by PTCRIS: 126236 EXPL/NEU-NMC/0541/2012 Principal investigator Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/06 - 2013/06	In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging grant.Provided by PTCRIS: 103538 Researcher Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2011/09/30	The role of mRNA translation in the formation of the neuromuscular junction. PTDC/SAU-NEU/104100/2008 Research Technician Fellow Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2010	Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools PIC/IC/83206/2007 Researcher	Fundação para a Ciência e a Tecnologia
2008 - 2010	Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease PTDC/SAU-NEU/71675/2006 Researcher	Fundação para a Ciência e a Tecnologia
2006 - 2010	PhD project: Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors SFRH/BD/28403/2006 PhD Student Fellow CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015 - 2018	Funding of RD Units Strategic Plan - 2013/2015 - OE UID/NEU/04539/2013 Researcher Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2014	Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE PEst-C/SAU/LA0001/2013 Researcher Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/06/01 - 2013/06/30	Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento PTDC/SAU-NEU/103538/2008 Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/03 - 2011/02	Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine n/a Researcher	Lundbeck foundation (portuguese office)

Other

	Designation	Funders
2005 - 2006	Cross-talk between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids n/a Researcher Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	L’Oréal Portugal/UNESCO/FCT Concluded

Outputs

Publications

Book chapter	Costa, Rui O.; Perestrelo, Tânia; Tomé, Diogo; Almeida, Ramiro D.. "A Microfluidic Culture Platform for Neurotrophin Signaling Studies". In Brain-Derived Neurotrophic Factor (BDNF), 185-201. Springer New York, 2018. Published • 10.1007/7657_2018_9 Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, United States: Nova Science Publishers, Inc.,, 2008. Published
Conference abstract	Costa RO; Lacor, P.N.; Klein, W.L.; Rego AC; Cláudia Pereira. "Alzheimers disease-associated amyloide peptide oligomers induce endoplasmic reticulum stress throught N-Methyl-D- Aspartate receptors in hippocampal neurons". Paper presented in Federation of European Neuroscience Societies (2010), Amsterdam, 2010. Published Ferreiro, E.; Rui O Costa; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C.R.; Pereira, C.. "10.1016/j.jns.2009.02.158 Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Paper presented in 5th International Congress on Vascular Dementia, Budapest, 2009. Published • 10.1016/j.jns.2009.02.158 Pereira, Cláudia M.F.; Ferreiro, Elisabete B.; Rui O Costa; Resende, Rosa M.M.B.; Cardoso, Sandra M.; Oliveira, Catarina R.. "10.1016/j.jalz.2008.05.1011 P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide". Paper presented in 11ª International conference on Alzheimer's Disease and Reletaded Disorders, Chicago, 2008. Published • 10.1016/j.jalz.2008.05.1011 Costa RO; Elisabete Ferreiro; CR Oliveira; Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition". Paper presented in Federation of European Neuroscience Societies (FENS), Geneva, 2008. Published Costa RO; Elisabete Ferreiro; Catarina Resende de oliveira; Claudia pereira. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". Paper presented in 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry, 2007. Published
Conference paper	Ferreira I.L.; Mota S.I.; Costa RO; Padovano C.; Fonseca A.C.; Letra L.; Oliveira C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Paper presented in AD/PD 2011, Barcelona, 2011. Published Costa RO; P.N. Lacor; I.L. Ferreira; A.C. Rego; W.L. Klein; C. Pereira. "Role of N-Methyl-D- Aspartate receptors in endoplasmic reticulum stress induced by amyloide peptide oligomers". Paper presented in AD/PD 2009, Prague, 2009. Published Elisabete Ferreiro; Rosa Resende; Costa RO; P Moreira; Sandra Cardoso; Cláudia Pereira; CR Oliveira. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Paper presented in European Meeting of the Society-for-Free-Radical-Research-Europe, 2007. Published
Conference poster	Silva, Marta; Duarte, Carlos B.; Costa, Rui. "The RNA-binding protein hnRNP H2: a novel player in neurodevelopmental disorders and epileptogenesis". Paper presented in iMed Conference 15.0, 2023. Tahiri, Emanuel; Alexandra Filipa almeida Santos; Marta Sofia Santos Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Corresponding author: Costa, Rui. "Intra-axonal autophagosome biogenesis impairment in Alzheimer’s disease". Paper presented in ISN-ESN 2023 Porto, Portugal, 2023. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Corresponding author: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Paper presented in BEB DAY 2023 in Coimbra on the days 7th and 8th of February (https://cnc.uc.pt/en/pdbeb/beb-news/beb-day-2023-1), 2023. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Corresponding author: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Paper presented in 2nd symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics (https://www.adconferences.com/), 2023. Claudia Corso; Giorgio Belperio; Cinzia Miarelli; Rodrigues, Catarina; Filipe Duarte; Costa, Rui; Duarte, Carlos B.; Mele, Miranda. "K+-Cl- cotransporter (KCC2) activation as a novel therapeutic strategy for epilepsy". Paper presented in 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra, 2022. Tomé D; Martins LF; Costa RO; Serra SC; Duarte CB; Pinheiro PS; Salgado AJ; Almeida RD. "Regenerative and synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Paper presented in VIII European Synapse Meeting (Coimbra, Portugal), 2022. Tahiri, Emanuel; Alexandra Santos; Duarte, Carlos B.; Costa RO. Corresponding author: Costa RO. "Intra-axonal autophagy dysfunction: an early event in Alzheimers disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021 #NNR-71, 2021. Costa RO; Tomé, Diogo; Martins, Luís; Lia G Carvalhais; Sofia C Serra; Paulo S Pinheiro; Duarte, Carlos B.; Antonio J Salgado; Almeida, Ramiro D. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021. Guilherme G Trigo; Joana R Pedro; Diogo Tomé; Costa RO; Ramiro D Almeida. "Intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". 2021. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021. Tomé D; Martins LF; Carvalhais LG; Costa RO; Serra SC; Pinheiro PS; Duarte CB; Salgado AJ; Almeida RD. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (Coimbra, Portugal), 2021. Costa RO; Tahiri, Emanuel; Marta Silva; Duarte, Carlos B.. Corresponding author: Costa RO. "Intra-axonal autophagy dysfunction in Alzheimer’s disease". Paper presented in EMBO Workshop Axons 2021; structure and function, 2021. Miranda Mele; Cinzia Miarelli; Giorgio Belperio; Giovanna Lombardi; Filipe Valente Duarte; Costa RO; Carlos B. Duarte. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Paper presented in Congresso Virtual da LPCE - 33º eENE, 2021. Diogo Tomé; Luís F. Martins; Costa RO; Sofia C. Serra, Nuno Sousa, António J. Salgado & Ramiro D. Almeida. "Mesenchymal stem cells secretome induces synapse formation in central nervous system neurons.". Paper presented in Secretive With]Out[ Borders meeting, Braga, Portugal, 6- 7th December, 2018., 2018. Costa RO; Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "Mechanisms underlying ribosomal regulation in axonal development". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016., 2016. Luís F. Martins; Costa RO; Susana Sampaio, Joana Pedro, Sofia Serra, Nuno Sousa, António Salgado, Ramiro Almeida. "Mesenchymal stromal cells secretome-induced axonal outgrowth is mediated by BDNF". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016. Joana Pedro; Maria Joana Pinto; Costa RO; Pedro Alves, Hyun Ryu, Noo Li Jeon Samie Jaffrey & Ramiro Almeida. "Presynaptic differentiation triggered by target-derived cue is mediated by local protein synthesis". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016. Costa RO; Joana R. Pedro, Maria Joana Pinto, Hyun R. Ryu, Noo Li Jeon, Samie R. Jaffrey & Ramiro D. Almeida. "Intra-axonal translation is required for synapse formation". Paper presented in SFN 2014 meeting, Washington DC, USA, November 15th-19th, 2014, 2014. Joana R. Pedro; Maria Joana Pinto; Costa RO; Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "Intra-axonal translation of ß-actin is required for presynaptogenesis". Paper presented in 4th European synapse meeting, Bordeux, France August 28th-30th, 2013, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Paper presented in 9th FENS forum of Neuroscience, Milan, Italy, July 5th-9th, 2013, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto; Hyunryul Ryu; Noo Li Jeon; Samie Jaffrey; Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Paper presented in 9th FENS forum of Neuroscience, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Paper presented in CNC meeting, Biocant, Cantanhede, December 19th-20th, 2012, 2012. Mota, S.I.; Costa RO; Caldeira G.L., Santana I., Padovano C., Fonseca A.C., Letra L., Oliveira C., Ferreira I.L., Perei. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Paper presented in Neurodegenerative Diseases Meeting, Cold Spring Harbor, New York, USA, Nov 28th-Dec 1st, 2012. equal contibution, 2012. Fonseca A.C.; Ferreira I.L.; Costa RO; Mota S.I., Padovano C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Paper presented in Sinal, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, April 29th-30st, 2011, 2011. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C., Fonseca A.C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Paper presented in 10th International Conference AD/PD, Barcelona, Spain, March 9th-13th, 2011, 2011. Martins I.; Gomes S.; Costa RO; Martins I., Gomes S., Costa R.O., Resende R., Oliveira C.R., Pereira C.M.. "Effect of leptin and ghrelin in hippocampal neurons against Alzheimer ´s disease neurotoxins – amyloid-beta peptide". Paper presented in XVII National Congress of Biochemistry, Oporto, Portugal, December 15th-17th, 2010, 2010. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M.. "Ghrelin and leptin protect hippocampal neurons and hypothalamic cells against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer ´s disease.". Paper presented in 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, November 28th-30th 2010, 2010. Costa RO; Lacor P.N., Klein W.L., Rego A.C. and Pereira C.. "Alzheimer’s disease-associated amyloid-peptide oligomers induce endoplasmic reticulum stress through N-methyl-D- aspartate receptors in hippocampal neurons.". Paper presented in 7th FENS, Forum of European Neuroscience, Amsterdam, The Neatherlands, July 3rd-7th, 2010, 2010. Elisabete Ferreiro; Costa RO; Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudia Pereira.. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Paper presented in 7th FENS, Forum of European Neuroscience, Amsterdam, The Netherlands, July 3rd-7th, 2010, 2010. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M. "Leptin and Ghrelin protect against Aß-induced toxicity in hippocampal and hypothalamic neurons". Paper presented in Final Annual Network Meeting, ENINET, Coimbra, Portugal, May 6th-8th, 2010, 2010. Oliveira C.R.,; Ferreira I.L.; Costa RO; Mota S.I., Bajouco M., Lacor P.N., Klein W.L., Rego A.C., Pereira C.. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Paper presented in 39th Annual Meeting of the American Society for Neuroscience (SFN). Chicago, USA, October 17th-21th, 2009., 2009. Costa RO; Ferreira IL, Rego AC, Klein WL, Pereira C.. "Role of N-methyl-D-aspartate receptors in endoplasmic reticulum stress induced by Aß oligomers". Paper presented in 9th Internacional Conferente on Alzheimer’s and Parkinson’s Diseases (AD/PD), Prague, Czech Republic. March 11th -15th, 2009, 2009. Elisabete Ferreiro; Costa RO; Rosa Resende, Sueli Marques, Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudi. "Communication between endoplasmic reticulum and mitochondria in neuronal death induced by amyloid-beta peptide.". Paper presented in 5th International Congress on Vascular Dementia, Budapest, Hungary, November 8th-11th, 2008, 2008. Pereira C.,; Ferreiro E.; Costa RO; Resende R., Cardoso S., Oliveira C.R. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer’s disease- associated beta-amyloid peptide". Paper presented in 11th International Conference on Alzheimer’s Disease and Related Disorders. Chicago, USA, 26th-31st July, 2008, 2008. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira e Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition.". Paper presented in 6th FENS, Forum of European Neuroscience, Geneva, Switzerland. June 12th-16th, 2008, 2008. Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sueli Marques; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Paper presented in Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira, Cláudia Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to Alzheimer´s disease". Paper presented in 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal, May 25th, 2007, 2007. Elisabete Ferreiro; Costa RO; Catarina R. Oliveira, Cláudia Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on Alzheimer’s disease cybrids.". Paper presented in 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Salzburg, Austria, March 15th-18th, 2007, 2007. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Paper presented in XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Paper presented in XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006. Ana Gouveia; Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "“Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer.". Paper presented in V Congresso de Investigação em Medicina, Coimbra, Portugal. November 23rd-24th, 2006., 2006. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira e Cláudia Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Paper presented in 10th International Conference on Alzheimer’s disease and related disorders, Madrid, Spain, July 15th-20th, 2006*, 2006.
Journal article	Rui O. Costa; Luís F. Martins; Emanuel Tahiri; Carlos B. Duarte. "Brain-derived neurotrophic factor -induced regulation of RNA metabolism in neuronal development and synaptic plasticity". WIREs RNA (2022): https://doi.org/10.1002/wrna.1713. 10.1002/wrna.1713 Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D.. "Isolation and Culture of Chick Ciliary Ganglion Neurons". Journal of Visualized Experiments 162 (2020): http://dx.doi.org/10.3791/61431. 10.3791/61431 Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080. 10.1016/j.celrep.2019.06.080 Mele, Miranda; Costa, Rui O.; Duarte, Carlos B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00077. 10.3389/fncel.2019.00077 Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos; Costa RO. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551. 10.21769/bioprotoc.2551 Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS. 10.1038/s41598-017-03592-1 Costa, R.O.; Perestrelo, T.; Almeida, R.D.. "PROneurotrophins and CONSequences". Molecular Neurobiology (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS. 10.1007/s12035-017-0505-7 Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017. 10.1523/ENEURO.0268-17.2017 Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D.. "Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)". Frontiers in Molecular Neuroscience 9 JUNE (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS. 10.3389/fnmol.2016.00043 Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS. 10.1016/j.bbadis.2015.03.015 Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS. 10.1016/j.neuroscience.2013.02.062 Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS. 10.1016/j.mcn.2012.09.005 Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS. 10.1155/2012/735206 Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2011.04.011 Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS. 10.1111/j.1474-9726.2012.00848.x Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS. 10.3233/JAD-2010-091369 Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS. 10.1111/j.1471-4159.2007.05048.x Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS. 10.1016/j.nbd.2006.05.011
Manual	Santos-Carvalho, Ana; Rui O Costa; Maria Inês Morte; Pedro Alves. Fisiologia Celular e Biologia Molecular. Portugal. 2013.
Preprint	Pasqualino De Luca; Miranda Mele; Sara Tanqueiro; Francesca Napoli; Ugné Butkeviciute; Arthur C. Souto; Rui O. Costa; et al. "Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in epileptogenesis". 2024. https://doi.org/10.1101/2024.10.21.618702. 10.1101/2024.10.21.618702 Salazar, Ivan L.; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; Costa, Rui O.; Caldeira, Margarida V.; Trader, Darci J; Duarte, Carlos B.. "Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons". 2024. http://dx.doi.org/10.1101/2024.05.15.594129. 10.1101/2024.05.15.594129
Thesis / Dissertation	Pereira, Cláudia Maria Fragão; Palmeira, Carlos. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". PhD, 2011. http://hdl.handle.net/10316/18243.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/06	Amyloid-ß oligomers impair intra-axonal autophagy	GEECD 2022 (Portugal)
2022/06	The role of intra-axonal autophagy in Alzheimer’s disease	GEECD 2022 (Portugal)
2022/04/23	Da ideia à publicação dos resultados: Como se faz (neuro)ciência?	MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/) Meet.LAB (Coimbra, Portugal)
2020/06/03	Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons	Portuguese Postdoc exchange program Instituto Gulbenkian de Ciência (ICG) - Portugal (WEBINAR, Portugal)
2017/02	Axonal regulation of ribosome content during development	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02	Local application of MSCs secretome induces axonal elongation in CNS neurons	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2013/06	Oxidative and ER stress in early stages of Alzheimer’s disease	13a Reunião da Sociedade Portuguesa de Neurociências Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04	Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease	Oxidative Stress & Disease -The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease Gordon Conference Gordon Conference (Les Diablerets, Switzerland)
2013/03/23	Alzheimer’s Disease: Biochemical Approaches to Molecular Mechanisms	VI Encontro Nacional de Estudantes de Bioquímica VI Encontro Nacional de Estudantes de Bioquímica (Aveiro, Portugal)
2012/06	Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease	26a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2012/03/17	Percurso académico e ciêntifico. O nosso actual trabalho laboratorial.	Simpósio:Jovens cientistas no IEC Instituto de Educação e Cidadania (IEC) (Mamarrosa, Oliveira do bairro, Portugal)
2010/06	Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06	Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer’s disease	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06	Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2009/06	Endoplasmic reticulum stress in hippocampal neurons induced by Alzheimer’s disease-Associated amyloid-beta oligomers. Role of NR2A and NR2B subunits of N-Methyl-D-ASpartate (NMDA) receptor	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06	O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na doença de Alzheimer	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2007/06	Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2006/12	Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides.	XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/06	Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2022/10 - Current	Autophagy dysfunction in axons: new evidence for Alzheimer´s disease pathogenesis UI/BD/154202/2022 Supervisor of Emanuel Tahiri	Doutoramento em neurociências - Experimental Biology and Biomedicine (BEB) (PhD) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra, Portugal
2022/09/01 - Current	The RNA-binding protein hnRNPH2: a novel player in epileptogenesis Supervisor of Marta Sofia Santos Silva	Biologia Celular e Molecular (Master) Universidade de Coimbra, Portugal
2022/03/01 - 2023/02/24	The role of heterogeneous ribonuclear proteins in Epilepsy and autism spectrum disorders. Supervisor of Giovanna Di Pietro	Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari Università degli Studi del Sannio, Italy Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/10 - 2022/09	Autophagosome biogenesis and axonal transport dysfunction in Alzheimer’s disease Supervisor of Alexandra Filipa Almeida Santos	Biologia Celular e Molecular (Master) Universidade de Coimbra, Portugal
2021/09 - 2022/09	The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2 Co-supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/09/10 - 2021/12/13	Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation Co-supervisor of Guilherme Gomes Trigo	Biomedicina Molecular (Master) Universidade de Aveiro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/10 - 2021/10	Early autophagy dysfunction in Alzheimer’s Disease: the role of WIPI2 Supervisor of Emanuel Tahiri	Biologia Celular e Molecular (Master) Università degli Studi del Sannio, Italy Universidade de Coimbra, Portugal
2020/03/01 - 2021/02/24	Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development. Co-supervisor of Giorgio Belperio	Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Master) Università degli Studi di Napoli Federico II, Italy Università degli Studi del Sannio, Italy Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014/09/08	Modulation of synaptic mRNA composition Co-supervisor of Helena Sofia Caria Martins	Modulation of synaptic mRNA composition (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2021/11/19 - Current	Seminar: Amyloid beta oligomers in neurodegeneration and neurodevelopment. Professor William Klein, Department of Neurobiology, Weinberg College o Arts & Sciences, Northwestern University, USA Friday, November 19, 2021, 3 pm @ Zoom Meeting Host: Rui O. Costa, CNC www.cnc.uc.pt/pt/seminars (2021/11/19) Seminar (Co-organisor)	Universidade de Coimbra, Portugal
2012 - 2014	Co-organizer of the Cell Physiology and Molecular Biology course lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)” (4 courses of 10 classes, 3 hours each. Total = 120 hours). Co-author of protocol manual book used in Cell Physiology and Molecular Biology courses lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)”. (2012 - 2014) Other (Co-organisor)	Instituto de Educação e Cidadania, Portugal

Event participation

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2021/12	Perturbation of endoplasmic reticulum-mitochondria crosstalk in bipolar disorder: effect of sigma-1 receptor modulation (Thesis) Main arguer	Ana Rita Azevedo Henriques da Cunha (Master) Universidade de Coimbra, Portugal
2021/10/11	Early autophagy dysfunction in Alzheimers disease: the role of WIPI2 Supervisor	Emanuel Tahiri (Master) Universidade de Coimbra, Portugal
2021	Desenvolvimento de um hidrogel de lisados de plaquetas para indução de regeneração nervosa (Thesis) Main arguer	Joana Filipa Ribeiro Correia (Master) Universidade de Aveiro, Portugal
2020/09/24	LAEB - Defesa de Monografia: "Development of new hydrogels for stem-cell differentiation" (Thesis) Main arguer	Sofia Catarina Ponce Dias (Master) Universidade de Aveiro Departamento de Física, Portugal
2019/09/12	Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth (Thesis) Main arguer	João Miguel Miranda da Rocha (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/03	Study of Tau and Synaptogyrin-3 interaction - A drug discovery approach (Thesis) Main arguer	Ana Filipa Martins de Oliveira (Master) Hospitais da Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/27	Development of immunoassays on the Simoa platform to detect and differentiate Tau species at very low concentrations (Thesis) Main arguer	Dina Rodrigues Martins (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/13	Assaying synaptic function using genetically -encoded optical reporters in the context of Alzheimer´s disease (Thesis) Main arguer	Catarina Franco Quitério de Oliveira Borges (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/12	Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology (Thesis) Main arguer	Joana de Freitas Fresco Rodrigues Costa (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/28	Apreciação do Projecto de tese: "The Role of endocytosis in BDNF-induced axonal outgrowth and branching" (Thesis) Main arguer	Luís Filipe Maximino Martins (PhD) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/13	The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates (Thesis) Main arguer	Alberto José Carpinteiro Soares (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/16	Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases (Thesis) Main arguer	Nuno Miguel Ferreira Morais Apóstolo (Master) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

	Society Organization name	Role
2021/02 - Current	Liga Portuguesa contra a Epilepsia (LPCE)	Member (Sócio)
2006 - Current	Sociedade Portuguesa de Neurosciências (Portuguese Society for Neurosciences)	Member
2006 - Current	Sociedade Portuguesa de Bioquímica (Portuguese society for Biochemistry)	Member

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2024/05/24 - Current	From idea to publication of results: Cell cultures and other strategies.	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2024/05/24 - Current	From idea to publication of results: Cell cultures and other strategies.	Bioquímica (Licenciatura)	Universidade do Algarve, Portugal
2024/05/24 - Current	From idea to publication of results: Cell cultures and other strategies.	Biotecnologia (Licenciatura)	Universidade do Algarve, Portugal
2022/11/25 - Current	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, November 25th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.25 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2022/02/07 - Current	Lecturer at the doctoral program - PDBEB course on 'Synapse Biology', University of Coimbra. 2022, February 7th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours)	Programa doutoral em Experimental Biology and Biomedicine (BEB) (Curso de doutoramento (conclusão de unidades curriculares))	Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/11/03 - Current	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2021, November 3rd. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.4 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2021/03/22 - Current	Lecturer at the doctoral program - PDBEB course on 'Synapse structure and function', University of Coimbra. 2021, March 22th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours)	Experimental Biology and Biomedicine (BEB)	Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2019/04/09 - Current	Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, April 9th. (Lecture on the ¿Development of the nervous system and neuronal polarity and axon pathfinding¿, Total = 3 hours)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2014 - Current	Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal.	(Mestrado)	Universidade de Coimbra, Portugal
2023/02/27 - 2023/03/01	Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2023, February 27th-March 1st. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours)	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2023/01/16 - 2023/01/20	Lecturer at the doctoral program - PDBEB course on 'SSynapse assembly, function and plasticity (16-20 January 2023). 1 Lecture on the - Study of axonal transport and analysis with kymographs , Total = 1 week)	programa doutoral BEB	Universidade de Coimbra, Portugal
2022/12/02 - 2022/12/05	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, December 2th and 5th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis, presentation of final works). Total = 6 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2022/03/28 - 2022/03/30	Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2022, March 28th-30th. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours)	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2022/01/10 - 2022/01/10	Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2022, January 10th. (1 Lecture on neuronal development, Total = 2 hours)	Bioquímica (Licenciatura)	Universidade do Algarve, Portugal
2021/01/04 - 2021/01/04	Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2021, January 4th. (1 Lectures on neuronal development, Total = 2 hours)	Bioquímica (Licenciatura)	Universidade do Algarve, Portugal
2019/10/08 - 2019/10/08	Lecturer at the Cell regulation course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, October 8th. (Total = 2.5 hours)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2019/03/25 - 2019/03/26	Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, March 25th-26th. (4 Lectures on the “Development of the nervous system and neuronal polarity and axon pathfinding”, Total = 4.5 hours)	Biologia Celular e Molecular (Mestrado)	Universidade de Coimbra, Portugal
2012 - 2014	Teacher of an Experimental Science Course – Cell Physiology and Molecular Biology lectured in the highschool “Escola Secundária de Oliveira do Bairro (ESOB)”, for students of “9º ano de escolaridade”. (4 courses of 10 classes, 3 hours each. Total = 120 hours)	Cell Physiology and Molecular Biology (Ensino secundário)	Instituto para a Educação e a Cidadania, Portugal
2013 - 2013	Invicted lecturer. Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. “Diverse Approaches To Molecular Mechanisms”. 1 lecture. Total = 3h	Medicina (Mestrado integrado)	Universidade de Coimbra, Portugal
2012 - 2013	Teacher in the Course "Do gene à proteína", lectured in the “Instituto para a Educação e a Cidadania (IEC), host in Mamarrosa, concelho de Oliveira do Bairro, Portugal. For highschool students. (8 classes, 3 hours each. Total = 24 hours)	(Ensino secundário)	Instituto para a Educação e a Cidadania, Portugal
2010 - 2010	Colaborator in Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. 2010.	Medicina (Mestrado integrado)	Universidade de Coimbra, Portugal
2007 - 2008	Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal.	Laboratory rotations for students of the Master in Cell and Molecular Biology (Mestrado)	Universidade de Coimbra, Portugal
2006 - 2006	Supervisor of laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine, CNC, University of Coimbra.	Laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	CNC.IBILI, Portugal

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2019/08/09	Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author.	Diário as Beiras
2019/08/08	Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author.	Público
2013/03/28	Interview related to the program "pais com ciência" sponsored by "Ciência viva", in which the program "programa de ciência experimental para o ensino básico" was inserted. The advanced courses in "Cell Physiology and Molecular Biology Course", with the main function of science awareness, were lectured by Rui Costa and Pedro Alves to 48 students and 8 high school teacher during 2 years (2013-2014) at the ESOB (high school at Oliveira do Bairro, Portugal).	Diário da Bairrada

Interview (tv / radio show)

	Program	Topic
2013/06/25 - 2013/06/25	RTP - Notícias. (The portuguese national tv channel). Interview regarding the advanced courses in Cell Physiology and Molecular Biology Course lectured by Rui O Costa and co-conceived by Rui O Costa and IEC (Instituto para a Educação e Cidadania) to high-school 48 students and 8 teachers for 2 years (2013-2014).	Cell Physiology and Molecular Biology

Journal scientific committee

	Journal title (ISSN)	Publisher
2021/10 - Current	Aging Cell
2017 - Current	Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165)	Elsevier
2017 - Current	Heliyon (2405-8440)	Elsevier
2017 - Current	Oxidative Medicine and Cellular Longevity (1942-0994)	Hindawi Limited
2016 - Current	Neurochemical Research (1573-6903)	Springer-Verlag
2015 - Current	Data in Brief (2352-3409)	Elsevier

Mentoring / Tutoring

	Topic	Student name
2023/02 - Current	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). The role of hnRNP H2 in MRXSB.	Afonso Lourinho
2017 - Current	PhD student tutoring at University of Coimbra, Portugal. "The effect of mesenchymal stem cells secretome on post-injury synapse formations"	Diogo Alexandre da Silva Tomé
2021/10 - 2022/05	The role of BDNF in autophagy	Carlos Avilés Granados
2022/03/01 - 2022/03/31	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). Investigation of the role of BDNF in autophagy modulation of synaptic plasticity	João Videira Duarte Henriques
2022/03/01 - 2022/03/31	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Investigating the impact of Aß oligomers in the axonal retrograde transport of autophagic structures by JIP1	Rafael de Oliveira Patarra
2021/02/15 - 2021/06	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) )	Marta Sofia Santos Silva
2020/08/01 - 2020/10/31	Tutoring in summer course. Alterações nas sinápses GABAérgicas num modelo de epileptogénese in vitro.	Giorgio Belperio
2020/03 - 2020/07	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Anabela Pereira Tomás
2015/09 - 2019/09	PhD student tutoring at University of Coimbra, Portugal. " Secreted molecules in neuronal development and disease".	Luis Filipe Maximino Martins
2018 - 2018	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Magda Ferreira Rodrigues
2018 - 2018	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Raquel Sofia Inácio Pinto
2016 - 2016	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Diogo António Jarró Margato
2016 - 2016	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Manuel Morais Jorge Coelho
2012 - 2013	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) "	Rita Filipe de Almeida Neves
2011 - 2013	Master student tutoring at University of Coimbra, Portugal. "Role of local protein synthesis in presynaptogenesis."	Luís Filipe Maximino Martins
2008 - 2009	Master student tutoring at University of Coimbra, Portugal. "Neuroprotection by leptin and grelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease."	Isaura Vanessa Antunes Martins
2008/04 - 2008/08	Master student tutoring at the university of Coimbra, Portugal. "Role of Mithocondrial Dysfunction on Tau Hyperphosphorylation."	Alessandro De Stefano

Distinctions

Award

2024	Best oral communication at "Encontro nacional de epileptologia" (ENE), Coimbra, 2024 Liga Portuguesa Contra a Epilepsia, Portugal
2022	Scientific Incentive Grant 2022 -Portuguese Epilepsy foundation (LPCE)
2022	Scholarship to attend the 8th European Synapse Meeting (ESM) (2022)
2013	Postdoctoral fellowship by FCT (SFRH/BPD/84593/2012) Fundação para a Ciência e a Tecnologia, Portugal
2007	Travel Grant to attend the 21s Bienal Meeting of the International Society for Neurochemistry FLAD - Fundação Luso Americana Para o desenvolvimento, Portugal
2007	Travel Grant to attend the 21st Bienal Meeting of the International Society for Neurochemistry SPB - Sociedade Portuguesa de Bioquímica, Portugal
2006	Full PhD fellowship by FCT (SFRH/BD/28403/2006) Fundação para a Ciência e a Tecnologia, Portugal

Title

2011	PhD in Biology Universidade de Coimbra, Portugal

	Activity description Type of event	Event name Institution / Organization
2022/04/23 - Current	Invited speaker at the VI meet lab. O meet.Lab Coimbra é um evento organizado pelo Núcleo de Estudantes de Biologia da Associação Académica de Coimbra, com uma forte vertente de laboratório. Meeting	MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
2022 - Current	HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022 Symposium	HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
2006 - Current	Collaborator in “Brain Awarness Week” , at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra.	“Brain Awarness Week” CNC.IBILI, Portugal
2006 - Current	Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra.	“Ciência Viva” programme CNC.IBILI, Portugal
2021/12/01 - 2021/12/03	XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, Coimbra, Portugal, from 1– 3 December 2021 Meeting	XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
2021/10/04 - 2021/10/07	EMBO Workshop Axons 2021; structure and function 4-7 October 2021. Participated with the poster: Thu-PO-3-19 Intra-axonal autophagy dysfunction in Alzheimer¿s disease. Rui O. Costa, Emanuel Tahiri, Marta Silva, Carlos B. Duarte Workshop	EMBO Workshop: Axons 2021: structure and function
2021/03/12 - 2021/03/13	Congresso virtual da LPCE (33º eENE) Congress	Congresso virtual da LPCE (33º eENE)
2020/01/23 - 2020/01/24	The Neurobiology of Socio-Sexual Behavior (6h of Lectures). This mini symposium was organized by the Center for Neuroscience and Cell Biology and the Master Program in Cellular and Molecular Biology of the University of Coimbra. Symposium	The Neurobiology of Socio-Sexual Behavior CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016/06/17 - 2016/06/24	Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 (Duration 12h). Workshop	Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2016/06/01 - 2016/06/04	ISN 2016 meeting, Coimbra, Portugal. Meeting	ISN 2016 (international society for neurochemistry)
2014/11/15 - 2014/11/19	SFN 2014 meeting, Washington DC, USA. Meeting	SFN 2014 meeting (Society for Neuroscience)
2012 - 2014	Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness. Advanced courses in Biology for students and high school teachers - "Curso avançado de Biologia Do gene à Proteína" Other	Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness Instituto de Educação e Cidadania, Portugal
2013/05/27 - 2013/05/27	Workshop: "Grant Writing and Funding Opportunities" Workshop	Workshop: "Grant Writing and Funding Opportunities" Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2012/12/04 - 2012/12/06	Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME); Zen imaging software. Coimbra, Portugal Workshop	Advanced fluorescence microscopy workshop CNC.IBILI, Portugal
2010/11/29 - 2010/12/03	Image processing and analysis in cell physiology. Advanced Training Workshop Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal. Workshop	Image processing and analysis in cell physiology. Universidade de Aveiro, Portugal
2010/07/03 - 2010/07/07	7th FENS, Fórum of European Neuroscience, Amsterdam, The Neatherlands. Meeting	7th FENS, Forum of European Neuroscience
2010/04/13 - 2010/04/13	Technical Seminar: “RNA World: not so small”. CNC, University of Coimbra, Portugal. Seminar	“RNA World: not so small”. CNC.IBILI, Portugal
2010/01/11 - 2010/01/15	Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC, University of Coimbra, Portugal. 2010, January 11th-15th. Other	Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC. CNC.IBILI, Portugal
2009/09/02 - 2009/09/04	Course on Multifluorescence Microscopy. Training content: Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME). Coimbra, Portugal. 2009, September 2nd-4th. Workshop	Course on Multifluorescence Microscopy CNC.IBILI, Portugal
2009/06/25 - 2009/06/26	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal. Meeting	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
2009/03/11 - 2009/03/15	9th Internacional Conferente AD/PD, Prague, Czech Republic. Conference	9th Internacional Conferente AD/PD, Prague, Czech Republic.
2008/06 - 2009/03	Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" given by Doctor William L. Kein, at Northwestern University, Evanston, Chicago. 2008, September-March. Other	Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" lectured by Doctor William L. Kein Northwestern University - Chicago, United States
2008/06/26 - 2008/06/27	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Meeting	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2008/06/12 - 2008/06/16	6th FENS, Fórum of European Neuroscience, Geneva, Switzerland. Meeting	6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
2008/06/06 - 2008/06/07	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Meeting	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/06/08 - 2007/06/09	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Meeting	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/05/25 - 2007/05/26	Meeting Portuguese Society for Neurosciences, Ofir, Portugal. Meeting	Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
2007/01/29 - 2007/02/02	Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Other	Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. 2007, January 29th-February 2nd. CNC.IBILI, Portugal
2007/01/22 - 2007/01/26	Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Other	Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2007/01/15 - 2007/01/19	Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Other	Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2007/01/08 - 2007/01/10	Biostatistics. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal Other	Biostatistics. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2006/12/08 - 2006/12/10	XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal. Congress	XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
2006/11/23 - 2006/11/24	V Congresso de Investigação em Medicina, Coimbra, Portugal. Congress	V Congresso de Investigação em Medicina (Congress on Investigation in Medicine), Coimbra, Portugal.
2006/06/23 - 2006/06/24	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal. Meeting	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.