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Péter Szücs has an MD (1998) and acquired his PhD (2003) in neurobiology/theoretical medicine at the University of Debrecen. At present he is an associate professor and head of the Department of Anatomy, Histology and Embryology at the University of Debrecen, Hungary. His research group focuses on the anatomical and functional connectivity and development of the superficial dorsal horn of the spinal cord. In collaboration with Boris Safronov’s group in Porto he described the detailed axon morphology and connectivity of lamina I projection- and interneurons. More recently, he uses optogenetics to reveal descending and local modulation of the spinal dorsal horn circuitry and the role of local axon collaterals of projection neurons. . He co-authored 40 peer-reviewed publications and participated (3 times as PI) in research grants from the European Union, FCT and the National Research, Development and Innovation Office of Hungary.
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Identification

Personal identification

Full name
Peter Szucs

Citation names

  • Szucs, Peter

Author identifiers

Ciência ID
8D18-A919-829E
ORCID iD
0000-0003-4635-6427

Email addresses

  • szucs.peter@med.unideb.hu (Professional)

Telephones

Mobile phone
  • (+36) 303494746 (Personal)

Addresses

  • Dept. Anatomy, Histology and Embryology - University of Debrecen. Nagyerdei krt. 98., 4032, Debrecen, HBM, Hungary (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Hungarian (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Russian Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Beginner (A1)
Portuguese Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2003
Concluded
 theoretical medicine / health sciences (Doutoramento)
Debreceni Egyetem Általános Orvostudományi Kar, Hungary
"Combined electrophysiological and morphological investigation of substance P (SP) - neurokinin 1 (NK1) receptor interaction in the spinal cord and dorsal root ganglia of the rat" (THESIS/DISSERTATION)
 summa cum laude
1998
Concluded
 medicine (Mestrado)
Debreceni Egyetem Általános Orvostudományi Kar, Hungary
"Neurokinin-1 Receptor Expression in Dorsal Root Ganglion Neurons of Young Rats" (THESIS/DISSERTATION)
 summa cum laude
Affiliation

Science

Category
Host institution 		Employer
2002/09/23 - 2002/12/23 Visiting Researcher (Research) Universite de Strasbourg IUT Louis Pasteur, France

Teaching in Higher Education

Category
Host institution 		Employer
2013/09/01 - 2016/06/30 Associate Professor (University Teacher) Debreceni Egyetem Általános Orvostudományi Kar, Hungary
2006/09/01 - 2007/09/30 Assistant Professor (University Teacher) Debreceni Egyetem Általános Orvostudományi Kar, Hungary
2002/09/01 - 2006/08/31 Lecturer (University Teacher) Debreceni Egyetem Általános Orvostudományi Kar, Hungary
1998/09/01 - 2002/08/31 Tutor (University Teacher) Debreceni Egyetem Általános Orvostudományi Kar, Hungary

Others

Category
Host institution 		Employer
2016/07/01 - Current Head of Department Debreceni Egyetem Általános Orvostudományi Kar, Hungary
2013/01/01 - 2013/07/31 prof. auxiliar convidado Universidade do Porto Faculdade de Medicina, Portugal
2008/01/01 - 2012/12/31 Ciencia 2007 - Aux. Investigator Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2007/10/01 - 2007/12/31 Postdoctoral fellow (SFRH / BPD / 37675 / 2007) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projects

Grant

Designation Funders
2021/11/01 - 2024/10/31 Patient-centered Targeting of Epigenetic Vulnerabilities in Neurodevelopmental Disorders: A Cross-disciplinary Platform for Druggable Disease Models (EPINEURODEVO)
EPINEURODEVO
Researcher
Debreceni Egyetem Általános Orvostudományi Kar, Hungary
Ongoing
2018 - 2021 Synapses and axons: multiscale functional and structural analysis of connections in the spinal cord and visual cortex
2017-1.2.1-NKP-2017-00002
Principal investigator
Debreceni Egyetem Általános Orvostudományi Kar, Hungary
 National Research, Development and Innovation Office
Ongoing
Outputs

Publications

Journal article
  1. Fernandes EC; Carlos-Ferreira J; Luz LL; Kokai E; Meszar Z; Szucs P; Safronov BV. "Processing of trigeminocervical nociceptive afferent input by neuronal circuity in the upper cervical lamina I.". Pain (2022): http://europepmc.org/abstract/med/33990106.
    10.1097/j.pain.0000000000002342
  2. Ducza L; Szücs P; Hegedus K; Bakk E; Gajtkó A; Wéber I; Holló K. "NLRP2 Is Overexpressed in Spinal Astrocytes at the Peak of Mechanical Pain Sensitivity during Complete Freund Adjuvant-Induced Persistent Pain.". International journal of molecular sciences (2021): http://europepmc.org/abstract/med/34768839.
    10.3390/ijms222111408
  3. Kapitány A; Medgyesi B; Jenei A; Somogyi O; Szabó L; Gáspár K; Méhes G; et al. "Regional Differences in the Permeability Barrier of the Skin-Implications in Acantholytic Skin Diseases.". International journal of molecular sciences (2021): http://europepmc.org/abstract/med/34638769.
    10.3390/ijms221910428
  4. Varga, Angelika; Mészár, Zoltán; Sivadó, Miklós; Bácskai, Tímea; Végh, Bence; Kókai, Éva; Nagy, István; Szücs, Péter. "Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents". International Journal of Molecular Sciences 22 5 (2021): 2297. http://dx.doi.org/10.3390/ijms22052297.
    Published • 10.3390/ijms22052297
  5. Fernandes, E.C.; Pechincha, C.; Luz, L.L.; Kokai, E.; Szucs, P.; Safronov, B.V.. "Primary afferent-driven presynaptic inhibition of C-fiber inputs to spinal lamina I neurons". Progress in Neurobiology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081970286&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2020.101786
  6. Baksa, B.; Kovács, A.; Bayasgalan, T.; Szentesi, P.; Koszeghy, Á.; Szücs, P.; Pál, B.. "Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus". Cellular and Molecular Life Sciences 76 14 (2019): 2799-2815. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061242629&partnerID=MN8TOARS.
    10.1007/s00018-019-03025-4
  7. Luz, L.L.; Fernandes, E.C.; Dora, F.; Lukoyanov, N.V.; Szucs, P.; Safronov, B.V.. "Trigeminal Ad- and C-afferent supply of lamina I neurons in the trigeminocervical complex". Pain 160 11 (2019): 2612-2623. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073584886&partnerID=MN8TOARS.
    10.1097/j.pain.0000000000001659
  8. Papp, R.; Nagaraj, C.; Zabini, D.; Nagy, B.M.; Lengyel, M.; Maurer, D.S.; Sharma, N.; et al. "Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension". European Respiratory Journal 53 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067373440&partnerID=MN8TOARS.
    10.1183/13993003.00965-2018
  9. Fernandes, E.C.; Santos, I.C.; Kokai, E.; Luz, L.L.; Szucs, P.; Safronov, B.V.. "Low-and high-threshold primary afferent inputs to spinal lamina III antenna-type neurons". Pain 159 11 (2018): 2214-2222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055077326&partnerID=MN8TOARS.
    10.1097/j.pain.0000000000001320
  10. Torres-Pérez, J.V.; Sántha, P.; Varga, A.; Szucs, P.; Sousa-Valente, J.; Gaal, B.; Sivadó, M.; et al. "Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85010799947&partnerID=MN8TOARS.
    10.1038/srep41221
  11. Fernandes, E.C.; Luz, L.L.; Mytakhir, O.; Lukoyanov, N.V.; Szucs, P.; Safronov, B.V.. "Diverse firing properties and Aß-, Ad-, and C-afferent inputs of small local circuit neurons in spinal lamina I". Pain 157 2 (2016): 475-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955580965&partnerID=MN8TOARS.
    10.1097/j.pain.0000000000000394
  12. Conde-Sousa, E.; Szücs, P.; Peng, H.; Aguiar, P.. "N3DFix: an Algorithm for Automatic Removal of Swelling Artifacts in Neuronal Reconstructions". Neuroinformatics (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978143735&partnerID=MN8TOARS.
    10.1007/s12021-016-9308-7
  13. Antal, Z.; Luz, L.L.; Safronov, B.V.; Antal, M.; Szücs, P.. "Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs". Brain Structure and Function 221 4 (2016): 2343-2360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928404102&partnerID=MN8TOARS.
    10.1007/s00429-015-1046-3
  14. Kovács, A.; Bordás, C.; Bíró, T.; Hegyi, Z.; Antal, M.; Szücs, P.; Pál, B.. "Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice". Brain Structure and Function (2016): 1-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966697436&partnerID=MN8TOARS.
    10.1007/s00429-016-1214-0
  15. Antal, Z.; Luz, L.L.; Safronov, B.V.; Antal, M.; Szücs, P.. "Erratum to: Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs (Brain Struct Funct, 2016, 10.1007/s00429-015-1046-3)". Brain Structure and Function 221 4 (2016): 2399-2400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929673971&partnerID=MN8TOARS.
    10.1007/s00429-015-1063-2
  16. Simandi, Z.; Czipa, E.; Horvath, A.; Koszeghy, A.; Bordas, C.; Põliska, S.; Juhász, I.; et al. "PRMT1 and PRMT8 regulate retinoic acid-dependent neuronal differentiation with implications to neuropathology". Stem Cells 33 3 (2015): 726-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923228096&partnerID=MN8TOARS.
    10.1002/stem.1894
  17. Luz, L.L.; Fernandes, E.C.; Sivado, M.; Kokai, E.; Szucs, P.; Safronov, B.V.. "Monosynaptic convergence of somatic and visceral C-fiber afferents on projection and local circuit neurons in lamina I: A substrate for referred pain". Pain 156 10 (2015): 2042-2051. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954496887&partnerID=MN8TOARS.
    10.1097/j.pain.0000000000000267
  18. Sousa, M.; Szucs, P.; Lima, D.; Aguiar, P.. "The pronociceptive dorsal reticular nucleus contains mostly tonic neurons and shows a high prevalence of spontaneous activity in block preparation". Journal of Neurophysiology 111 7 (2014): 1507-1518. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900810824&partnerID=MN8TOARS.
    10.1152/jn.00440.2013
  19. Luz, L.L.; Szucs, P.; Safronov, B.V.. "Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: A new circuit for gating pain responses". Journal of Physiology 592 7 (2014): 1519-1534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897413853&partnerID=MN8TOARS.
    10.1113/jphysiol.2013.269472
  20. Koszeghy, Á.; Kovács, A.; Bíró, T.; Szücs, P.; Vincze, J.; Hegyi, Z.; Antal, M.; Pál, B.. "Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes". Brain Structure and Function 220 5 (2014): 3023-3041. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940602256&partnerID=MN8TOARS.
    10.1007/s00429-014-0842-5
  21. Aguiar, P.; Sousa, M.; Szucs, P.. "Versatile morphometric analysis and visualization of the three-dimensional structure of neurons". Neuroinformatics 11 4 (2013): 393-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886291005&partnerID=MN8TOARS.
    10.1007/s12021-013-9188-z
  22. Szucs, P.; Luz, L.L.; Pinho, R.; Aguiar, P.; Antal, Z.; Tiong, S.Y.X.; Todd, A.J.; Safronov, B.V.. "Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord". Journal of Comparative Neurology 521 12 (2013): 2719-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879484866&partnerID=MN8TOARS.
    10.1002/cne.23311
  23. Antal, Z.; Szucs, P.; Antal, M.. "Lamotrigine effectively blocks synaptic transmission between nociceptive primary afferents and secondary sensory neurons in the rat superficial spinal dorsal horn". Interventional Medicine and Applied Science 3 1 (2011): 22-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865308825&partnerID=MN8TOARS.
    10.1556/IMAS.3.2011.1.5
  24. Papachatzaki, M.M.; Antal, Z.; Terzi, D.; Szücs, P.; Zachariou, V.; Antal, M.. "RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn". Neuroscience Letters 501 1 (2011): 31-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960976933&partnerID=MN8TOARS.
    10.1016/j.neulet.2011.06.033
  25. Luz, L.L.; Szucs, P.; Pinho, R.; Safronov, B.V.. "Monosynaptic excitatory inputs to spinal lamina I anterolateral-tract-projecting neurons from neighbouring lamina I neurons". Journal of Physiology 588 22 (2010): 4489-4505. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449251557&partnerID=MN8TOARS.
    10.1113/jphysiol.2010.197012
  26. Szucs, P.; Luz, L.L.; Lima, D.; Safronov, B.V.. "Local axon collaterals of lamina I projection neurons in the spinal cord of young rats". Journal of Comparative Neurology 518 14 (2010): 2645-2665. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954566628&partnerID=MN8TOARS.
    10.1002/cne.22391
  27. Pinto, V.; Szucs, P.; Lima, D.; Safronov, B.V.. "Multisegmental Ad- and C-fiber input to neurons in lamina I and the lateral spinal nucleus". Journal of Neuroscience 30 6 (2010): 2384-2395. http://www.scopus.com/inward/record.url?eid=2-s2.0-76649088934&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3445-09.2010
  28. Santos, S.F.A.; Luz, L.L.; Szucs, P.; Lima, D.; Derkach, V.A.; Safronov, B.V.. "Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord". PLoS ONE 4 11 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77951251897&partnerID=MN8TOARS.
    10.1371/journal.pone.0008047
  29. Szucs, P.; Pinto, V.; Safronov, B.V.. "Advanced technique of infrared LED imaging of unstained cells and intracellular structures in isolated spinal cord, brainstem, ganglia and cerebellum". Journal of Neuroscience Methods 177 2 (2009): 369-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-58249113129&partnerID=MN8TOARS.
    10.1016/j.jneumeth.2008.10.024
  30. Pinto, V.; Szûcs, P.; Derkach, V.A.; Safronov, B.V.. "Monosynaptic convergence of C- and Ad-afferent fibres from different segmental dorsal roots on to single substantia gelatinosa neurones in the rat spinal cord". Journal of Physiology 586 17 (2008): 4165-4177. http://www.scopus.com/inward/record.url?eid=2-s2.0-51749099196&partnerID=MN8TOARS.
    10.1113/jphysiol.2008.154898
  31. Wéber, I.; Veress, G.; Szucs, P.; Antal, M.; Birinyi, A.. "Neurotransmitter systems of commissural interneurons in the lumbar spinal cord of neonatal rats". Brain Research 1178 1 (2007): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448993794&partnerID=MN8TOARS.
    10.1016/j.brainres.2007.06.109
  32. Papp, I.; Szucs, P.; Holló, K.; Erdélyi, F.; Szabó, G.; Antal, M.. "Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsal horn". European Journal of Neuroscience 24 5 (2006): 1341-1352. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748745543&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2006.05013.x
  33. Ferraguti, F.; Klausberger, T.; Cobden, P.; Baude, A.; Roberts, J.D.B.; Szucs, P.; Kinoshita, A.; et al. "Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus". Journal of Neuroscience 25 45 (2005): 10520-10536. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744487501&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2547-05.2005
  34. Hughes, D.I.; Mackie, M.; Nagy, G.G.; Riddell, J.S.; Maxwell, D.J.; Szabó, G.; Erdélyi, F.; et al. "P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn". Proceedings of the National Academy of Sciences of the United States of America 102 25 (2005): 9038-9043. http://www.scopus.com/inward/record.url?eid=2-s2.0-21144437771&partnerID=MN8TOARS.
    10.1073/pnas.0503646102
  35. Ganter, P.; Szücs, P.; Paulsen, O.; Somogyi, P.. "Properties of horizontal axo-axonic cells in stratum oriens of the hippocampal CA1 area of rats in vitro". Hippocampus 14 2 (2004): 232-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842779933&partnerID=MN8TOARS.
    10.1002/hipo.10170
  36. Melnick, I.V.; Santos, S.F.A.; Szokol, K.; Szûcs, P.; Safronov, B.V.. "Ionic Basis of Tonic Firing in Spinal Substantia Gelatinosa Neurons of Rat". Journal of Neurophysiology 91 2 (2004): 646-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842327882&partnerID=MN8TOARS.
    10.1152/jn.00883.2003
  37. Szûcs, P.; Odeh, F.; Szokol, K.; Antal, M.. "Neurons with distinctive firing patterns, morphology and distribution in laminae V-VII of the neonatal rat lumbar spinal cord". European Journal of Neuroscience 17 3 (2003): 537-544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037330062&partnerID=MN8TOARS.
    10.1046/j.1460-9568.2003.02484.x
  38. Maccaferri, G.; Roberts, J.D.B.; Szucs, P.; Cottingham, C.A.; Somogyi, P.. "Erratum: (Journal of Physiology (2000) vol. 524 (91-116))". Journal of Physiology 528 3 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034325912&partnerID=MN8TOARS.
  39. Maccaferri, G.; Roberts, J.D.B.; Szucs, P.; Cottingham, C.A.; Somogyi, P.. "Cell surface domain specific postsynaptic currents evoked by identified GABAergic neurones in rat hippocampus in vitro". Journal of Physiology 524 1 (2000): 91-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034177736&partnerID=MN8TOARS.
  40. Szucs, P.; Polgar, E.; Spigelman, I.; Porszasz, R.; Nagy, I.. "Neurokinin-1 receptor expression in dorsal root ganglion neurons of young rats". Journal of the Peripheral Nervous System 4 3-4 (1999): 270-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033392404&partnerID=MN8TOARS.
  41. Polgár, E.; Szücs, P.; Urbán, L.; Matesz, K.; Nagy, I.. "Immunohistochemical localization of neurokinin-1 receptor in the lumbar spinal cord of young rats: Morphology and distribution". Somatosensory and Motor Research 16 4 (1999): 361-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033404762&partnerID=MN8TOARS.
  42. Polgár, E.; Szûcs, P.; Urbán, L.; Nagy, I.. "Alterations of substance P immunoreactivity in lumbar and thoracic segments of rat spinal cord in ultraviolet irradiation induced hyperalgesia of the hindpaw". Brain Research 786 1-2 (1998): 248-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032498883&partnerID=MN8TOARS.
    10.1016/S0006-8993(97)01434-0
  43. Szucs, P.; Polgar, E.; Nagy, I.. "Spinal cord neurons in which interaction between N-methyl-D-aspartate and neurokinin-1 receptors may occur". Neurobiology 4 3 (1996): 281-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030561839&partnerID=MN8TOARS.
  44. Kulik, Á.; Polgár, E.; Matesz, C.; Szúcs, P.; Kothalawala, S.; Nagy, I.. "Sub-population of capsaicin sensitive primary afferent neurons in thoracic, lumbar and sacral dorsal root ganglion in young rats revealed by stimulated cobalt uptake". Acta Biologica Hungarica 47 1-4 (1996): 251-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030345821&partnerID=MN8TOARS.
Distinctions

Other distinction

2013 Bolyai Janos research fellowship
2009 Prémio Grünenthal DOR - MELHOR TRABALHO INVESTIGAÇÃO BÁSICA
Fundação Grünenthal, Portugal