Patrícia Costa Reis (8E15-17E7-F52D)

Curriculum Vitae

Patrícia Costa Reis

Patrícia Costa Reis is a Pediatric Rheumatologist and a Pediatric Nephrologist at Hospital de Santa Maria, an Assistant Professor of Pediatrics in Faculdade de Medicina - Universidade de Lisboa, a member of the Portuguese Technical Committee on Vaccines and a researcher at the Gulbenkian Institute for Molecular Medicine (GIMM). Patrícia is committed to the study of the pathogenesis of systemic lupus erythematosus, in order to find new clinically relevant pathways. On her Ph.D., Patrícia Costa Reis focused on the epigenetics of lupus nephritis, conducting her research at the Children's Hospital of Philadelphia - University of Pennsylvania. Her findings were published in several scientific journals, including two papers at Arthritis and Rheumatology, as first author, and a review at Nature Rev Rheum. Her work showed that HER2 controls mesangial cell proliferation in lupus nephritis and that urinary HER2 is a biomarker of disease activity. These findings established strong foundations for the use of the already available anti-HER2 drugs for lupus nephritis treatment. Afterwards, Patrícia Costa Reis conducted a pediatric prospective multicenter study that showed the clinical value of urinary HER2 to predict a lupus nephritis flare. Patrícia Costa Reis was granted a patent for the clinical use of HER2 in lupus nephritis. Patrícia was interested in studying the sex bias in lupus and X chromosome inactivation and was awarded a Fundação para a Ciência e Tecnologia exploratory grant in 2022. Recently, Patrícia is also interested in studying the interplay between diet, gut microbiota, intestinal permeability and endotoxemia and chronic inflammation. Patrícia was awarded the D. Manuel de Mello grant to study this topic in Lupus and an Horizon Europe grant, as a member of the consortium ENDOTARGET, to focus on this topic in rheumatoid arthritis and spondyloarthritis. Patrícia Costa Reis is an author of more than 30 papers in peer-reviewed journals (total number of citations > 600 and h-index=9) and an author of more than 170 scientific communications in national and international meetings, including oral communications at the ACR, EULAR, PRSYM, ESPN and IPNA meetings, as first or last author. She has been invited to give more than 60 talks, including at the ESPN and IPNA meetings (meet the expert). Patrícia Costa Reis is the head of the Research Center of the Pediatrics Department in Hospital de Santa Maria. She has supervised 19 Medicine Master Students and 3 MSc students. She is currently supervising 1 PhD and 1 MSc student and co-supervising 2 PhD students. She has been the mentor of 4 pediatrics residents. She is a reviewer of 15 scientific journals and she has been a jury for several prizes and grants. Patrícia Costa Reis has participated in the Pint of Science initiative, the Cientista Regressa à Escola Program and in interviews for televisions, radio stations and newspapers to promote scientific awareness in the community. Patrícia Costa Reis was awarded with the Salomão Sequerra Amram Excellence in Medicine Award 1999-2005, the Lupus Foundation of America Preceptorship Award 2012 and the L'Oréal, FCT, UNESCO Prize for Women in Science 2018. Patrícia Costa Reis was awarded the title fellow of the European Society of Pediatric Nephrology, in 2024, for her clinical, academic and research work.

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Identification

Personal identification

Full name: Patrícia Costa Reis

Citation names

Patrícia Costa-Reis

Author identifiers

Ciência ID: 8E15-17E7-F52D

Email addresses

pcr.patricia@gmail.com (Professional)

Websites

https://www.linkedin.com/in/patr%C3%ADcia-costa-reis-82a17027/?originalSubdomain=pt (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology
Natural sciences - Biological Sciences - Molecular Biology
Medical and Health Sciences - Clinical Medicine - Paediatrics
Medical and Health Sciences - Clinical Medicine - Rheumatology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Portuguese (Mother tongue)

Education

	Degree	Classification
2018/01 Concluded	Medicina (Doutoramento) Major in Especialidade: Pediatria Universidade de Lisboa Faculdade de Medicina, Portugal "New Developments on the Pathogenesis of Systemic Lupus Erythematosus" (THESIS/DISSERTATION)	Academic Distinction and Highest Honor
2005 Concluded	Medicina (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal "n/a" (THESIS/DISSERTATION)	19

Affiliation

Science

	Category Host institution	Employer
2024 - Current	Principal Investigator (Research)	Gulbenkian Institute for Molecular Medicine, Portugal

2018 - 2024	Researcher (Research)	Instituto de Medicina Molecular, Portugal
	Instituto de Medicina Molecular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2018 - Current	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Medicina, Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal
2006/09/15 - 2009/12/31	Invited Assistant (University Teacher)	Universidade de Lisboa Faculdade de Medicina, Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal
2007/02/15 - 2009/06/30	Main Coordinator Teacher (Polytechnic Teacher)	Instituto Politécnico de Lisboa Escola Superior de Educação, Portugal
	Instituto Politécnico de Lisboa Escola Superior de Educação, Portugal

Other Careers

	Category Host institution	Employer
2024 - Current	Assistente graduado (Médica)	Hospital de Santa Maria, Portugal
	Hospital de Santa Maria, Portugal
2015 - 2024	Assistente (Médica)	Hospital de Santa Maria, Portugal
	Hospital de Santa Maria, Portugal

Others

	Category Host institution	Employer
2018 - Current	Member of the Portuguese Technical Committee on Vaccines	Direção-Geral da Saúde, Portugal
	Direção-Geral da Saúde, Portugal
2016/01/01 - Current	Pediatric Rheumatologist at the Pediatric Rheumatology Unit	Hospital de Santa Maria, Portugal
	Hospital de Santa Maria, Portugal
2015/12/01 - Current	Pediatric Nephrologist at the Pediatric Nephrology and Kidney Transplantation Unit	Hospital de Santa Maria, Portugal
	Hospital de Santa Maria, Portugal
2017/03/01 - 2017/04/30	Pediatric Nephrology and Kidney Transplantation Internship	Great Ormond Street Hospital For Children NHS Foundation Trust, United Kingdom
	Great Ormond Street Hospital For Children NHS Foundation Trust, United Kingdom
2007/01/01 - 2015/10/16	Pediatrics Residency	Hospital de Santa Maria, Portugal
	Hospital de Santa Maria, Portugal
2011/10/01 - 2014/09/30	Pediatric Rheumatology Research and Clinical Internship	The Children's Hospital of Philadelphia, United States
	The Children's Hospital of Philadelphia, United States
2010/01/01 - 2010/06/30	Pediatric Rheumatology Internship	NewYork-Presbyterian/Columbia University Medical Center, United States
	NewYork-Presbyterian/Columbia University Medical Center, United States

Projects

Grant

	Designation	Funders
2021/01/01 - Current	Study of the link between diet, physical activity, body composition, microbiota, gut permeability, metabolomics and lupus activity . Principal investigator Instituto de Medicina Molecular, Portugal	Fundação Amélia de Mello Ongoing
2020/09 - Current	Gut Permeability in Children and Adults with Systemic Lupus Erythematosus Lupus Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação Amélia de Mello Concluded
2020 - Current	Estudo PEGASUS: Prevalência de lesão renal aguda moderada a grave em crianças e adolescentes em unidades de cuidados intensivos pediátricas . Principal investigator	Associação para as Crianças de Santa Maria
2020 - Current	Cross-cultural adaptation and validation of LoSQI measure in juvenile localised scleroderma . Researcher Alder Hey Children's NHS Foundation Trust, United Kingdom	Paediatric Rheumatology INternational Trials Organisation Ongoing
2014 - Current	Urinary HER2 as a Biomarker for lupus Nephritis Activity . Principal investigator The Children's Hospital of Philadelphia, United States	Childhood Arthritis and Rheumatology Research Alliance (CARRA) Ongoing
2023/01 - 2026/12	ENDOTARGET: Systemic Endotoxemia as the driver of chronic inflammation - Biomarkers and novel therapeutic targets for Arthritis 101095084 Co-Principal Investigator (Co-PI) Gulbenkian Institute for Molecular Medicine, Portugal	Horizon 2020 Ongoing
2023/01 - 2024/07	A tríade da nutrição, microbiota intestinal e Artrite Reumatóide - Um estudo piloto exploratório Provided by PTCRIS: 2022.07462.PTDC 2022.07462.PTDC 10.54499/2022.07462.PTDC Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/02	X Chromosome Inactivation in Systemic Lupus Erythematosus EXP/MED-OUT/1517/2021 Principal investigator Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2013 - 2017	Epigenetics of Lupus Nephritis . PhD Student Fellow The Children's Hospital of Philadelphia, United States	Fundação Calouste Gulbenkian Fundação Champalimaud Fundação para a Ciência e a Tecnologia Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP Concluded
2012/01/01 - 2014/12/30	New Developments on the Pathogenesis of Systemic Lupus Erythematosus SFRH / BD / 79384 / 2011 PhD Student Fellow	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Instituto de Medicina Molecular João Lobo Antunes LA/P/0082/2020 10.54499/LA/P/0082/2020 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Other

	Designation	Funders
2020 - Current	TRANSIT-ON: Transition to Adulthood after Pediatric Transplantation . Researcher Hospital Universitario La Paz, Spain	ERN TransplantChild Ongoing
2019 - Current	Estudo da Sobrevivência e Sobrevida do Enxerto de Crianças e Adolescentes Transplantados Renais . Principal investigator Hospital de Santa Maria, Portugal
2017 - Current	Development of an Activity and Damage Index for Patients with Juvenile Systemic Sclerosis . Researcher Hamburg Centre for Pediatric Rheumatology, Germany
2017 - Current	Clinical utility of the intra-renal resistive index in pediatric renal transplantation . Researcher Great Ormond Street Hospital For Children NHS Foundation Trust, United Kingdom	Great Ormond Street Hospital For Children NHS Foundation Trust Ongoing
2014 - 2018	Study of the effects of lapatinib in a lupus nephritis mouse model . Researcher The Children's Hospital of Philadelphia, United States	Lupus Foundation of America Inc
2007 - 2009	Mortality Risk Factors in Cystic Fibrosis . Researcher Hospital de Santa Maria, Portugal	Concluded
2007 - 2009	Nutritional Status in Cystic Fibrosis Patients . Researcher

Outputs

Publications

Book chapter	Patrícia Costa-Reis. "The Epigenetics of Systemic Lupus Erythematosus". In The Epigenetics of Autoimmunity. Elsevier, 2018. Published
Conference abstract	Almada-Correia, I; Castro, Miguel; Motta, Carla; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Filipa Oliveira Ramos; Catarina Inês Marques de Sousa Mendes; et al. "DIET, GUT MICROBIOTA, AND INTESTINAL PERMEABILITY IN SYSTEMIC LUPUS ERYTHEMATOSUS (Oral CO-030)". Paper presented in 22º Congresso Nacional de Pediatria, Lisboa, 2022. Inês Almada-Correia; Castro, Miguel; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Catarina Inês Marques de Sousa Mendes; Ramirez, Mário; João Eurico Cortez Cabral da Fonseca; Patrícia Costa-Reis. "Oral communication: Vamos olhar para o intestino no lúpus eritematoso sistémico". Paper presented in XXVII Jornadas de Pediatria do Hospital de Santa Maria, Lisboa, 2022. Almada-Correia, Inês; Castro, Miguel; Catarina Sousa Guerreiro; Motta, Carla; Ramirez, Mário; João Eurico Cortez Cabral da Fonseca; Patrícia Costa-Reis. "Oral communication: Exploring the link between diet, microbiome, gut permeability, metabolomics and disease activity in Systemic Lupus Erythematosus". Paper presented in iMED Conference - Innovate Competition, 2021.
Conference paper	Almada-Correia, I; Castro, Miguel; Motta, Carla; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Filipa Oliveira Ramos; Catarina Inês Marques de Sousa Mendes; et al. "Gut permeability in lupus nephritis: results from the GUT-LUPUS study (COL17)". Paper presented in VII Congresso Hispano-Português de Nefrologia Pediátrica 2023 and XLVI Congreso Español de Nefrologia Pediátrica 2023, Lisboa, 2023. Almada-Correia, I; Castro, Miguel; Motta, Carla; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Filipa Oliveira Ramos; Catarina Inês Marques de Sousa Mendes; et al. "Resultados do Estudo Gut-Lupus: Dieta, Composição Corporal, Microbiota e Permeabilidade Intestinal no Lúpus Eritematoso Sistémico (Oral 01)". Paper presented in I Congresso Português de Reumatologia Pediátrica, Lisboa, 2022.
Conference poster	Almada-Correia, I; Castro, Miguel; Motta, Carla; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Filipa Oliveira Ramos; Catarina Inês Marques de Sousa Mendes; et al. "Unraveling the mysteries of the connection between gut and the chronic activation of the immune system in Systemic Lupus Erythematosus (POS1426).". Paper presented in European Congress of Rheumatology (EULAR 2023), 2023. Castro M.; Motta, Carla; Almada-Correia, I; Sousa-Guerreiro C; Moura R; Patrícia Costa-Reis. "Exploring the link between diet, gut microbiota, gut permeability, and disease activity in Systemic Lupus Erythematosus". Paper presented in 28th Paediatric Rheumatology European Society Congress, 2022. Almada-Correia, I; Castro, Miguel; Motta, Carla; Catarina Sousa Guerreiro; Khmelinskii, Nikita; Filipa Oliveira Ramos; Catarina Inês Marques de Sousa Mendes; et al. "Exploring the link between diet, gut microbiota, gut permeability, and disease activity in Systemic Lupus Erythematosus (Poster 290)". Paper presented in 28th Paediatric Rheumatology European Society Congress, 2022.
Journal article	Vieira, Adriana A.; Almada-Correia, Inês; Inácio, Joana; Costa-Reis, Patrícia; da Rocha, S. T.. "Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?". Biology of Sex Differences 15 1 (2024): https://doi.org/10.1186/s13293-024-00650-y. 10.1186/s13293-024-00650-y Gallo, Paul M.; Chain, Robert W.; Xu, Jun; Whiteman, Leah M.; Palladino, Annette; Caricchio, Roberto; Costa-Reis, Patricia; Sullivan, Kathleen E.; Gallucci, Stefania. "EGFR-ErbB2 dual kinase inhibitor lapatinib decreases autoantibody levels and worsens renal disease in Interferon a-accelerated murine lupus". International Immunopharmacology 140 (2024): 112692. https://doi.org/10.1016/j.intimp.2024.112692. 10.1016/j.intimp.2024.112692 Miguel, Pedro J.; Moiteiro da Cruz, Rafael; Costa-Reis, Patrícia; Sandes, Ana Rita; Esteves da Silva, José. "Paracetamol Induced Acute Interstitial Nephritis: A Pediatric Case Report". Acta Médica Portuguesa 37 1 (2024): 67-69. https://doi.org/10.20344/amp.20563. 10.20344/amp.20563 Foeldvari, Ivan; Torok, Kathryn S.; Anton, Jordi; Blakley, Michael; Constantin, Tamás; Curran, Megan; Cutolo, Maurizio; et al. "Proposed Response Parameters for Twelve-Month Drug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings". Arthritis Care & Research 75 12 (2023): 2453-2462. https://doi.org/10.1002/acr.25171. 10.1002/acr.25171 Tomé, Catarina; Oliveira-Ramos, Filipa; Campanilho-Marques, Raquel; Mourão, Ana F.; Sousa, Sandra; Marques, Cláudia; Melo, Ana T.; et al. "Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation". RMD Open 9 3 (2023): e002901. https://doi.org/10.1136/rmdopen-2022-002901. 10.1136/rmdopen-2022-002901 Charneca, Sofia; Hernando, Ana; Costa-Reis, Patrícia; Guerreiro, Catarina Sousa. "Beyond Seasoning—The Role of Herbs and Spices in Rheumatic Diseases". Nutrients 15 12 (2023): 2812. https://doi.org/10.3390/nu15122812. 10.3390/nu15122812 Vilardouro, Ana Sofia; Cachão, Joana; Rodrigues, Márcia; Durão, Filipa; Costa-Reis, Patrícia; Sandes, Ana Rita; Silva, José Esteves da; Boto, Leonor; Stone, Rosário. "Hemolytic-uremic syndrome: 24 years’ experience of a pediatric nephrology unit". Brazilian Journal of Nephrology 45 1 (2023): 51-59. https://doi.org/10.1590/2175-8239-jbn-2021-0206. 10.1590/2175-8239-jbn-2021-0206 Patrícia Costa-Reis. "Barbosa Rodrigues A, Oliveira-Ramos F, Ferreira R, Camilo C, Oliveira T, Costa-Reis P. Eosinophilic Granulomatosis with Polyangiitis - description of a pediatric patient with severe disease". ARP Rheumatol (2023): Inês Almada-Correia; Patrícia Costa-Reis; Catarina Sousa Guerreiro; João Eurico Fonseca. "Let’s review the gut microbiota in systemic lupus erythematosus". Exploration of Medicine (2022): https://doi.org/10.37349/emed.2022.00112. 10.37349/emed.2022.00112 Foeldvari, Ivan; Klotsche, Jens; Kasapcopur, Ozgur; Adrovic, Amra; Terreri, Maria Teresa; Sakamoto, Ana Paula; Stanevicha, Valda; et al. "Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort". Journal of Scleroderma and Related Disorders 8 2 (2022): 120-130. https://doi.org/10.1177/23971983221143244. 10.1177/23971983221143244 Costa-Reis, Patricia; Maurer, Kelly; Petri, Michelle A; Levy Erez, Daniella; Zhao, Xue; Faig, Walter; Burnham, Jon; et al. "Urinary HER2, TWEAK and VCAM-1 levels are associated with new-onset proteinuria in paediatric lupus nephritis". Lupus Science & Medicine 9 1 (2022): e000719. https://doi.org/10.1136/lupus-2022-000719. 10.1136/lupus-2022-000719 Foeldvari, Ivan; Klotsche, Jens; Kasapcopur, Ozgur; Adrovic, Amra; Terreri, Maria Teresa; Sakamoto, Ana Paula; Stanevicha, Valda; et al. "Differences Sustained Between Diffuse and Limited Forms of Juvenile Systemic Sclerosis in an Expanded International Cohort". Arthritis Care & Research 74 10 (2022): 1575-1584. https://doi.org/10.1002/acr.24609. 10.1002/acr.24609 Zinterl, Carolina; Costa-Reis, Patrícia; Esteves, Isabel Castro; Marques, José Gonçalo; Sousa, Ana Berta; Fonseca, João Eurico; Oliveira Ramos, Filipa. "The Added Value of a Multidisciplinary Clinic for Systemic Autoinflammatory Diseases". Journal of Multidisciplinary Healthcare Volume 15 (2022): 999-1010. https://doi.org/10.2147/jmdh.s351546. 10.2147/jmdh.s351546 Durkee-Shock, Jessica; Zhang, Anqing; Liang, Hua; Wright, Hannah; Magnusson, Julieann; Garabedian, Elizabeth; Marsh, Rebecca A.; et al. "Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry". The Journal of Allergy and Clinical Immunology: In Practice 10 5 (2022): 1334-1341.e6. https://doi.org/10.1016/j.jaip.2022.01.042. 10.1016/j.jaip.2022.01.042 Dias Curado, Ana; Zagalo, Ana; Durão, Filipa; Costa-Reis, Patrícia; Sandes, Ana Rita; Esteves da Silva, José Eduardo; Stone, Rosário. "SARS-CoV-2 infection in pediatric kidney transplant recipients". Clinical Transplantation (2022): http://dx.doi.org/10.1111/ctr.14623. 10.1111/ctr.14623 Foeldvari, Ivan; Klotsche, Jens; Hinrichs, Bernd; Helmus, Nicola; Kasapcopur, Ozgur; Adrovic, Amra; Sztajnbok, Flavio; et al. "Underdetection of Interstitial Lung Disease in Juvenile Systemic Sclerosis". Arthritis Care & Research 74 3 (2022): 364-370. https://doi.org/10.1002/acr.24499. 10.1002/acr.24499 Patrícia Costa-Reis. "Juvenile systemic lupus erythematosus triggered by Lamotrigine.". ARP Rheumatol (2022): 181-182. Published Patrícia Costa-Reis. "Kikuchi-Fujimoto disease - a case report of a paediatric patient.". ARP Rheumatol. (2022): Bernardo, Miguel; Martins, Joana; Martins, Miguel; Prata, Filipa; Costa-Reis, Patrícia; Ferrão, Anabela; João Palaré, Maria. "Autoimmune haemolytic anaemia following SARS-CoV-2 infection in a child: A clue to a systemic autoimmune disease". Pediatric Blood & Cancer 69 2 (2021): http://dx.doi.org/10.1002/pbc.29481. 10.1002/pbc.29481 Bernardo, Miguel; Martins, Joana; Martins, Miguel; Prata, Filipa; Costa-Reis, Patrícia; Ferrão, Anabela; João Palaré, Maria. "Autoimmune haemolytic anaemia following SARS-CoV-2 infection in a child: A clue to a systemic autoimmune disease". Pediatric Blood & Cancer 69 2 (2021): https://doi.org/10.1002/pbc.29481. 10.1002/pbc.29481 Foeldvari, Ivan; Klotsche, Jens; Kasapcopur, Ozgur; Adrovic, Amra; Terreri, Maria Teresa; Sakamoto, Ana Paula; Stanevicha, Valda; et al. "Differences sustained between diffuse and limited forms of juvenile systemic sclerosis in expanded international cohort. www.juvenile-scleroderma.com". Arthritis Care & Research (2021): http://dx.doi.org/10.1002/acr.24609. 10.1002/acr.24609 Fogaça da Mata, Miguel; Rebelo, Mónica; Sousa, Helena Sofia; Rocha, Alexandra; Miguel, Pedro; Oliveira Ramos, Filipa; Costa-Reis, Patrícia. "Sinus node disfunction in an adolescent with systemic lupus erythematosus". Lupus 30 2 (2020): 342-346. http://dx.doi.org/10.1177/0961203320974091. 10.1177/0961203320974091 Foeldvari, Ivan; Klotsche, Jens; Hinrichs, Bernd; Helmus, Nicola; Kasapcopur, Ozgur; Adrovic, Amra; Sztajnbok, Flavio; et al. "Under detection of interstitial lung disease in juvenile systemic sclerosis (jSSc)". Arthritis Care & Research (2020): http://dx.doi.org/10.1002/acr.24499. 10.1002/acr.24499 Doná, Daniele; Torres Canizales, Juan; Benetti, Elisa; Cananzi, Mara; De Corti, Federica; Calore, Elisabetta; Hierro, Loreto; et al. "Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare". Clinical Transplantation 34 10 (2020): http://dx.doi.org/10.1111/ctr.14063. 10.1111/ctr.14063 Costa-Reis, Patricia; Sullivan, Kathleen E. "Monogenic lupus: it's all new!". Current Opinion in Immunology 49 (2017): 87-95. http://dx.doi.org/10.1016/j.coi.2017.10.008. Published • 10.1016/j.coi.2017.10.008 Tsokos, George C.; Lo, Mindy S.; Reis, Patricia Costa; Sullivan, Kathleen E.. "New insights into the immunopathogenesis of systemic lupus erythematosus". Nature Reviews Rheumatology 12 12 (2016): 716-730. http://dx.doi.org/10.1038/nrrheum.2016.186. Published • 10.1038/nrrheum.2016.186 Patrícia Costa-Reis. "A New Era for Diagnosis and Treatment of Hemophagocytic Syndromes". Acta Pediatr Port (2016): Published Costa-Reis, Patrícia; Russo, Pierre A.; Zhang, Zhe; Colonna, Lucrezia; Maurer, Kelly; Gallucci, Stefania; Schulz, Steffan W.; et al. "The Role of MicroRNAs and Human Epidermal Growth Factor Receptor 2 in Proliferative Lupus Nephritis". Arthritis & Rheumatology 67 9 (2015): 2415-2426. http://dx.doi.org/10.1002/art.39219. Published • 10.1002/art.39219 Canna, Scott W.; Costa-Reis, Patrícia; Bernal, William E.; Chu, Niansheng; Sullivan, Kathleen E.; Paessler, Michele E.; Behrens, Edward M.. "Brief Report: Alternative Activation of Laser-Captured Murine Hemophagocytes". Arthritis & Rheumatology 66 6 (2014): 1666-1671. http://dx.doi.org/10.1002/art.38379. Published • 10.1002/art.38379 Shi, Lihua; Zhang, Zhe; Yu, Angela M.; Wang, Wei; Wei, Zhi; Akhter, Ehtisham; Maurer, Kelly; et al. "The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs". PLoS ONE 9 5 (2014): e93846. http://dx.doi.org/10.1371/journal.pone.0093846. Published • 10.1371/journal.pone.0093846 Costa-Reis, Patrícia; Weaver, Lehn K.; Behrens, Edward M.; Sullivan, Kathleen E.. "Chronic non-bacterial osteomyelitis in a patient with common variable immunodeficiency". Joint Bone Spine 81 2 (2014): 193-194. http://dx.doi.org/10.1016/j.jbspin.2013.08.005. Published • 10.1016/j.jbspin.2013.08.005 Costa-Reis, Patrícia; Nativ, Simona; Isgro, Josephine; Rodrigues, Teresa; Yildirim-Toruner, Cagri; Starr, Amy; Saiman, Lisa; Imundo, Lisa; Eichenfield, Andrew. "Major infections in a cohort of 120 patients with juvenile-onset systemic lupus erythematosus". Clinical Immunology 149 3 (2013): 442-449. http://dx.doi.org/10.1016/j.clim.2013.08.009. Published • 10.1016/j.clim.2013.08.009 Costa-Reis, Patrícia; Sullivan, Kathleen E.. "Genetics and Epigenetics of Systemic Lupus Erythematosus". Current Rheumatology Reports 15 9 (2013): http://dx.doi.org/10.1007/s11926-013-0369-4. Published • 10.1007/s11926-013-0369-4 Patrícia Costa-Reis. "Chronic Recurrent Multifocal Osteomyelitis". Journal of Clinical Immunology (2013): Published Fermeiro, J.; Reis, P.; Castanhinha, S.; Pereira, L.; Barreto, C.. "Methicillin-resistant Staphylococcus aureus infection – what impact in cystic fibrosis patients morbidity?". Journal of Cystic Fibrosis 7 (2008): S45. http://dx.doi.org/10.1016/s1569-1993(08)60172-1. 10.1016/s1569-1993(08)60172-1
Thesis / Dissertation	Patrícia Costa-Reis. "New developments on the pathogenesis of systemic lupus erythemstosus". PhD, Universidade de Lisboa Faculdade de Medicina, 2018. http://hdl.handle.net/10451/34135.

Intellectual property

Patent

Patrícia Costa-Reis. 2018. "HER2 for the Diagnosis and Treatment of Lupus Nephritis". United States.
Allowed

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/02	Corticosteroids minimization is achievable for children with lupus nephritis¿	20th International Pediatric Nephrology Association Congress International Pediatric Nephrology Association (Cape Town, South Africa)
2024	Year in Review - Translational Research	2.º Congresso Nacional de Reumatologia Pediátrica Sociedade Nacional de Reumatologia Pediátrica (Aveiro, Portugal)
2024	Síndrome Febril indeterminada em Reumatologia Pediátrica	Congresso Nacional de Pediatria Sociedade Portuguesa de Pediatria (Vilamoura, Portugal)
2023	Meet the expert- Lupus Nephritis	ESPN Annual Meeting ESPN - European Society of Pediatric Nephrology (vilnius, Lithuania)
2020/12	Raquitismo Hipofosfatémico Ligado ao X	XII Congresso Português de Osteoporose SPODOM
2020/12	How to define low disease activity/remission in juvenile systemic sclerosis renal disease?	Juvenile Systemic Sclerosis Internacional Research Group
2019	Epigenética da Nefrite Lúpica: do laboratório à prática clínica	Sessão Clínica do Serviço de Genética Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2019	Prevenir na doença grave – Prevenir a doença renal crónica no doente critico	XXV Jornadas Anuais de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2019	Exame Reumatológico	XXVI Jornadas de Pediatria de Leiria e Caldas da Rainha Serviços de Pediatria de Leiria e das Caldas da Rainha (Caldas da Rainha, Portugal)
2019	Clínica e Diagnóstico da Lesão Renal Aguda – Mesa Redonda de Nefrologia Pediátrica do 20.º Congresso Nacional de Pediatria	20.º Congresso Nacional de Pediatria Sociedade Portuguesa de Pediatria (Estoril, Portugal)
2019	Vacinação e Imunossupressão - Mesa Redonda de Reumatologia Pediátrica do 20.º Congresso Nacional de Pediatria	20.º Congresso Nacional de Pediatria; Estoril, Novembro 2019. Sociedade Portuguesa de Pediatria
2019	Renal Manifestations in Children with Juvenile Systemic Sclerosis	12th Hamburg Symposium on Juvenile Systemic Sclerosis Juvenile Systemic Sclerosis Research Working Group (Hamburg, Germany)
2019	Hipertensão arterial renovascular secundária a múltiplas lesões estenóticas e aneurismáticas da artéria renal	XXV Jornadas de Pediatria do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2019	Doença mista do tecido conjuntivo e síndrome de ativação macrofágica	Fórum de Reumatologia (Porto, Portugal)
2019	Outcome of transition of care in young adults with juvenile onset chronic rheumatic diseases	Congresso Português de Reumatologia Sociedade Portuguesa de Reumatologia
2019	24 anos de Transplante Renal Pediátrico num Centro de Referência: Estudo da Mortalidade e Sobrevida do Enxerto	20.º Congresso Nacional de Pediatria Sociedade Portuguesa de Pediatria (Estoril, Portugal)
2018	Actualização em Emergência Pediátrica: Lesão Renal Aguda	XXIV Jornadas Anuais de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2018	Lúpus eritematoso sistémico juvenil	Curso de Reumatologia Pediátrica do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria
2018	A criança com doença reumática crónica no Serviço de Urgência	Curso de Reumatologia Pediátrica do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2018	Síndrome Hemofagocítica: uma nova era no diagnóstico e tratamento	Sessões Clínicas do Centro Hospitalar Universitário do Algarve Departamento de Pediatria do Centro Hospitalar Universitário do Algarve (Faro, Portugal)
2018	Hemofagócitos: vilões ou heróis? Novas ideias sobre a Síndrome Hemofagocítica	Sessão Clínica do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2018	Assessment of renal involvement in Juvenile Systemic Sclerosis	11th Hamburg Symposium on Juvenile Systemic Sclerosis Juvenile Systemic Sclerosis Research Working Group (Hamburg, Germany)
2018	HER2 as a urinary biomarker of lupus nephritis activity	Young Investigators Meeting – Pediatric Rheumatology European Society Congress Pediatric Rheumatology European Society (Lisbon, Portugal)
2018	Urinary HER2 lupus nephritis biomarker study	21st Century Lupus Conference (New York, United States)
2018	Klebsiella Pneumoniae produtora de carbapenemases na criança com doença renal crónica	XXIV Jornadas de Pediatria do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2018	Nefrite Intersticial Aguda – uma apresentação rara de alergia ao paracetamol	XXIV Jornadas de Pediatria do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2017	Diagnóstico e Tratamento das Glomerulonefrites na Criança	Curso de Nefrologia Pediátrica Departamento de Pediatria do Hospital de Santa Maria (lisbon, Portugal)
2017	Lesão Renal Aguda na Criança	Curso de Nefrologia Pediátrica Departamento de Pediatria do Hospital de Santa Maria (lisbon, Portugal)
2017	Transplante Renal em Crianças e Adolescentes	Curso de Nefrologia Pediátrica Departamento de Pediatria do Hospital de Santa Maria (Lisbon, Portugal)
2017	Particularities of Pediatric Renal Transplantation	Junior Doctor’s International Meeting Junior Doctor’s International Meeting (Lisbon, Portugal)
2016	Actualização em Nefrite Lúpica - Mesa Redonda de Nefrologia Pediátrica do Congresso Nacional de Pediatria	Congresso Nacional de Pediatria Sociedade Portuguesa de Pediatria (Porto, Portugal)
2016	Desafios do Transplante Renal Pediátrico	III Curso de Doação e Transplantação Renal Centro de Formação do Hospital de Santa Maria (lisbon, Portugal)
2016	Síndrome Hemofagocitica	XXIII Jornadas Anuais de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria (lisbon, Portugal)
2016	Impact of Chronic Microbial Translocation on Systemic Lupus Erythematosus Transcriptome and Disease Activity	1st EULAR Immunology and Translational Rheumatology Course The European League Against Rheumatism (EULAR)
2016	Doença Linfoproliferativa pós-transplante em Crianças Transplantadas Renais: experiência de um centro	XV Congresso Luso-Brasileiro de Transplantação; II Encontro Ibérico de Transplantação (Porto, Portugal)
2015	Osteomielite Crónica Recorrente Multifocal	Curso de Doenças Auto-Inflamatórias Hospital de Santa Maria (lisbon, Portugal)
2015	Epidemiologia das Mortes numa Unidade de Oncologia Pediátrica (2005-2014)	XXI Jornadas de Pediatria do Departamento de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria
2014	Control of Cell Proliferation in Lupus Nephritis: The role of miRNAs and HER2	Pediatric Rheumatology Symposium of the American College of Rheumatology American College of Rheumatology (ACR)
2013	Are Hemophagocytes the Real Villains in Hemophagocytic Lymphohistiocytosis?	2nd São Paulo Advanced School on Primary Immunodeficiencies Hospital da Universidade de São Paulo (São Paulo, Brazil)
2013	miR-26a and miR-30b Dysregulation in Pediatric Lupus Nephritis	The European League Against Rheumatism (EULAR) Annual European Congress of Rheumatology The European League Against Rheumatism (EULAR) (Madrid, Spain)
2013	Epigenetics of Inflammation	University of Pennsylvania Perelman School of Medicine Research in Progress Seminar University of Pennsylvania Perelman School of Medicine (Philadelphia, United States)
2013	miR-26a, miR-30b and HER2: New Players on Lupus Nephritis Pathogenesis	American College of Rheumatology (ACR) Meeting 2013 American College of Rheumatology (ACR) (San Diego, United States)
2009	Nutrição: um Fator Determinante na Fibrose Quística	XXII Reunião Anual da Secção de Gastrenterologia, Hepatologia e Nutrição Pediátrica da Sociedade Portuguesa de Pediatria Sociedade Portuguesa de Pediatria
2008	Fatores de Mau Prognóstico em Crianças com Fibrose Quística	XV Jornadas de Pediatria do Hospital de Santa Maria Departamento de Pediatria do Hospital de Santa Maria
2008	Liver Disease in Cystic Fibrosis Patients	European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Hepatology Summer School European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) (Venice, Italy)
2008	Terapêutica Antibiótica Inalada nos Doentes com Fibrose Quística e Infecção a Pseudomonas aeruginosa	9.º Congresso Nacional de Pediatria Sociedade Portuguesa de Pediatria (Porto, Portugal)
2008	Prevalence of Metabolic Syndrome in a Portuguese Obese Adolescent Population According to the Different Definitions	18th Annual Meeting of the European Childhood Obesity Group European Childhood Obesity Group (Porto, Portugal)
2007	Mialgias de Esforço: Forma de Apresentação de Canalopatia	XV Jornadas de Pediatria de Leiria e Caldas da Rainha;

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - Current	Neonatal Acute Kidney Injury – new methods for early diagnosis and a new perspective on prognosis Co-supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2024 - Current	Determinants of vaccine responsiveness and infection risk in immunocompromised patients Co-supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2024 - Current	Exploring the link between diet, microbiota, gut permeability, metabolomics and disease activity in Systemic Lupus Erythematosus Supervisor of Inês Almada Correia	Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Síndrome de Rowell Pediátrica Supervisor	Estudos Básicos de Medicina (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Síndrome de kikuchi em idade pediátrica Supervisor	Estudos Básicos de Medicina (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Raquitismo hipofosfatémico ligado ao X: uma nova estratégia terapêutica Supervisor	Estudos Básicos de Medicina (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Efeitos do transplante renal no desenvolvimento estaturoponderal das crianças com doença renal crónica Supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Glomerulopatia de C3: revisão teórica e descrição de um caso clínico Supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	NGAL as a Novel Acute Kidney Injury Biomarker: A Narrative Review Supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021	Angioedema como apresentação de lúpus eritematoso sistémico juvenil: descrição de um caso clínico e revisão teórica Supervisor	Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2020	Granulomatose eosinofílica com poliangeíte: revisão teórica e discussão de caso clínico Supervisor	Estudos Básicos de Medicina (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019	Doença mista do tecido conjuntivo e síndrome de ativação macrofágica: um caso clínico na criança Supervisor	Estudos Básicos de Medicina Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019	Lúpus eritematoso sistémico Juvenil – caso clínico Supervisor	est (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018	Esclerose sistémica juvenil- revisão teórica e discussão de caso clínico Supervisor	Estudos Básicos de Medicina (Master) Universidade de Lisboa Faculdade de Medicina, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2024 - Current	Organization of the 18th Eurolupus Meeting (2025) Congress (Member of the Organising Committee)	European Lupus Society, Italy
2024 - 2024	Annual Meeting of the Portuguese Pediatric Nephrology Society (2024 - 2024) Congress (Member of the Organising Committee)	Sociedade Portuguesa de Nefrologia Pediátrica, Portugal
2016 - 2017	XXIII Jornadas Anuais de Pediatria do Hospital de Santa Maria - reunião clínica e científica sobre temas de Pediatria (2017) Congress (Member of the Organising Committee)	Hospital de Santa Maria, Portugal
2016 - 2017	Curso de Nefrologia Pediátrica (2017) Conference (Co-organisor)	Hospital de Santa Maria, Portugal
2014 - 2015	Curso de Doenças Auto-Inflamatórias (2015) Seminar	Hospital de Santa Maria, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019	Crioaglutinémia secundária a infeção: a propósito de um caso clínico President of the jury	Filipe André da Silva Pereira (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2019	Nutrição na Doença Inflamatória Intestinal em idade pediátrica President of the jury	Aluna: Joana Maria Alberto da Costa Canhoto (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2019	Transposição de grandes artérias; President of the jury	Ariana Gonçalves Marques (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2019	Filhos de mães com lúpus eritematoso sistémico: estudo retrospetivo sobre o acompanhamento obstétrico e neonatal num centro terciário português President of the jury	Joana Mourão Vietez Frade (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2017	Utilização de fármacos biológicos na doença inflamatória intestinal em idade pediátrica (Thesis) Main arguer	Aluna Maria Margarida Afonso Magalhães Lopes (Master) Universidade de Lisboa Faculdade de Medicina, Portugal

Committee member

	Activity description Role	Institution / Organization
2021 - Current	Member of the Board of the Portuguese Pediatric Nephrology Society Member	Sociedade Portuguesa de Pediatria, Portugal
2018 - Current	Member of the Portuguese Technical Committee on Vaccines This committee provides recommendations on the use of vaccines in the population. Members meet regularly to discuss scientific evidence related to vaccine effectiveness and safety, clinical trial results and data regarding outbreaks of vaccine-preventable diseases or changes in vaccine supply. I also provide expertise related to the use of vaccines in immunocompromised patients. Member	Direção-Geral da Saúde, Portugal
2021 - 2023	Portuguese Representative at the Young Pediatric Nephrology Network of the European Pediatric Nephrology Society	European Society of Pediatric Nephrology, Belgium

Conference scientific committee

	Conference name	Conference host
2025 - Current	18th European Lupus Meeting 2026	Euroepan Lupus Society

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2018 - Current	Pediatrics	Estudos Básicos de Medicina (Licenciatura)	Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2009	Histology and Development Biology	Estudos Básicos de Medicina (Licenciatura)	Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2009	Children Health	Educação de Infância (Licenciatura)	Instituto Politécnico de Lisboa Escola Superior de Educação, Portugal

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2019	Entrevista sobre os avanços recentes na investigação do lúpus eritematoso sistémico	Visão

Interview (tv / radio show)

	Program	Topic
2019 - Current	Os Dias do Futuro	Lúpus Eritematoso Sistémico - o que leva à doença, como se diagnostica, como se trata e como se pode saber mais sobre ela

Mentoring / Tutoring

	Topic	Student name
2020 - Current	Pediatrics Residency	Pedro João Miguel
2019 - Current	Pediatrics Residency	Ana Catarina Rodrigues

Other jury / evaluation

	Activity description	Institution / Organization
2021 - Current	Member of the Jury of the Portuguese Pediatric Nephrology Society Annual Scientific Prize	Sociedade Portuguesa de Pediatria, Portugal
2019 - Current	Member of the panel “Immunology, Infectious Diseases and Inflammation” of the Agence Nationale de la Recherche - ANR 2019

Distinctions

Award

2025	Best Oral Communication International Pediatric Nephrology Association, United States
2023	Best Oral Communication European Society of Pediatric Nephrology, Belgium
2018	L’Oreal, UNESCO, FCT Women in Science Award 2018 Fundação para a Ciência e a Tecnologia, Portugal United Nations Educational Scientific and Cultural Organization, France Fondation L'Oréal, France
2014	The Children’s Hospital of Philadelphia Poster Award 2014 The Children's Hospital of Philadelphia, United States
2014	Jaime Salazar de Sousa Excellence in Pediatrics Award 2014 Hospital de Santa Maria, Portugal
2013	American Academy of Immunology Poster Award 2013
2012	Lupus Foundation of America Anna Louise Harmon Memorial Preceptorship Award 2012 Lupus Foundation of America Inc, United States
2006	Salomão Sequerra Amram Excellence in Medicine Award 1999-2005 Universidade de Lisboa Faculdade de Medicina, Portugal
2004	Lisbon University Excellence Award 2003/2004 Universidade de Lisboa, Portugal
2003	Lisbon University Excellence Award 2002/2003 Universidade de Lisboa, Portugal

Title

2024	Fellow of the European Pediatric Nephrology Society European Society of Pediatric Nephrology, Belgium

Other distinction

2020	Louvor n.º 126/2020 Ministério da Saúde, Portugal
2010	Scholarship - Programme for Advanced Medical Education 3rd Edition Fundação para a Ciência e a Tecnologia, Portugal Fundação Calouste Gulbenkian, Portugal Fundação Champalimaud, Portugal