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After obtaining my bachelor’s degree in biology from the University of Trás-os-Montes e Alto Douro (UTAD), I pursued a master’s degree in Laboratorial and Clinical Biology and underwent training at the UTAD Veterinary Hospital (HVUTAD). Afterwards, I joined the Centro Interdisciplinar De Investigação Marinha E Ambiental (CIIMAR) as a research assistant, where I worked within a results-oriented setup, sponsored by an industrial partner, which equipped me with skills crucial to work with translational science. This experience allowed me to develop a strong understanding of the importance of industry-academia collaboration and how it can facilitate the translation of research findings into practical applications. In 2014 I started my Ph.D. at Instituto de Ciências Biomédicas Abel Salazar (ICBAS). My PhD was developed in the interface between academia (CIIMAR/ICBAS) and industry (ALGAPlus) and in an international setting as I worked as part of an EU-funded research project. My research focused on the modulation of nutrient metabolism and immune and stress responsiveness in aquaculture species. During my Ph.D., I was awarded a Scientific Mission grant that supported my work as a visiting researcher at Marine Resources & Ecosystem Studies (IMARES)-University of Wageningen, Holland. During my Ph.D., I gained experience in the use of dietary supplementation as a tool to manipulate the host metabolism improving immunity and increasing resistance to infectious diseases. Also, I was actively involved in training by tutoring 3 BSc, 5 MSc, and 2 PhD students within the research team. Overall, during the Ph.D. I published 5 articles in the scope of the thesis and the skills and expertise accumulated were determinant to collaborative works resulting in 8 other publications. Following opportunities to develop my work in infection, I secured a research assistant position at ICVS. My experience in animal experimentation and bacterial infections were crucial to work with the mouse and guinea-pig models of mycobacterial infection. As a result of my expertise in 2021, I was invited to participate as an independent researcher in a collaboration with i3s Institute (Porto). In 2022 I joined Ricardo Silvestre group as an assistant researcher to pursue my goal to work with immunometabolism and infection. My focus was to understand the intricate mechanistic level of connection between metabolism, epigenetic and immune effector functions aiming at designing new immunotherapeutic agents for Leishmaniasis treatment. In 2023 I joined the IMMUNA project, at CIIMAR, working in Benjamin Costas's group. The team aims to explore innovative and sustainable solutions to improve the health and well-being of farmed fish. The team's efforts encompass both a fundamental understanding of the underlying mechanisms and practical collaborations with industry partners.
Identification

Personal identification

Full name
Maria João Dias Peixoto

Citation names

  • Peixoto, MJ

Author identifiers

Ciência ID
8E1D-E161-8E2E
ORCID iD
0000-0002-4739-3409

Telephones

Mobile phone
  • 918267643 (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Earth and Environmental Sciences - Water Resources

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Elementary (A2) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2015 - 2018/12/12
Concluded
Ciência Animal (Doutoramento)
Major in Área de especialidade: Nutrição
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Seaweeds as functional aquafeed ingredients: Modulation of nutrient metabolism and stress responsiveness in aquaculture species " (THESIS/DISSERTATION)
Aprovado
2009 - 2012
Concluded
Biologia Clínica Laboratorial (Mestrado)
Universidade de Trás-os-Montes e Alto Douro, Portugal
""Lyfe-cycle exposure of Danio rerio to the human pharmaceutical clofibric acid"" (THESIS/DISSERTATION)
2005/09/30 - 2009/06/30
Concluded
Biologia (Licenciatura)
Major in Científico
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Histological characterization of kidney (anterior and posterior) of Tilapia (Oreochromis niloticus)." (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2023/09/01 - Current Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2017/08/01 - 2023/08/28 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013 - 2017 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Projects

Grant

Designation Funders
2014 - 2015 Seaweed extract supplementation on seabass metabolism
0094/07/15/32
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
2013/03/01 - 2014 Seleção e avaliação de estirpes de probióticos para uso na aquacultura do linguado (Solea senegalensis)
QREN, REF NO. 13551
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
2010/04/01 - 2011/07/01 The modulation of retinoid and thyroid signaling pathways by endocrine disrupting chemicals: invertebrate insights
PROJECT PTDC/MAR/115199/2009
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded

Contract

Designation Funders
2023/09/01 - Current Methionine and tryptophan as nutraceutical strategies to improve mucosal immunity and vaccine efficiency in fish
PTDC/CVT-CVT/7741/2020
Post-doc
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2023/08/28 Immunometabolic networks on Leishmania infection
PTDC/CVT-CVT/4808/2020
Research Technician Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2019 - 2021 lmmunogenetic determinants of susceptibility/resistance to Buruli ulcer: a family- and population-based study for a neglected tropical disease
PTDC/SAU-INF/31312/2017
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
2017 - 2019 Transcriptome analysis of animal models of spontaneous healing of Buruli ulcer
INFECT-ERA/0002/2015
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluded
2014 - 2016 Marine bioactives as functional aquafeed ingredients: Modulation of nutrient metabolism and stress responsiveness in aquaculture species
SEABIOPLAS FP7 - SME-2012
PhD Student Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
2014 - 2016 ALGADOURADA - Seleção e avaliação de macroalgas para uso como aditivos em dietas de dourada
PROMAR 31-03-05-FEP-0041
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
2014 - 2016 Aquatic species under psycho pharmaceuticals neuroendocrine effects
PTDC/AAG-MAA/2405/2012
Technical development
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Outputs

Publications

Conference paper
  1. F. Pereira, Luís; José F. M. Gonçalves; Domingues, A.; Peixoto, MJ; Braga SF; Sansuwan, K; Santos, G.; Ozório, R.O.A.. "Dietary probiotic supplementation improved gut amylase to trypsin ratio in European seabass reared at different temperatures and survival after handling stress". Paper presented in IMMR | International Meeting on Marine Research 2014, Peniche, 2014.
    Published • 10.3389/conf.fmars.2014.02.00016
Conference poster
  1. Domingues, A.; Peixoto, MJ; Batista, S; Gomes, A.; José Fernando M. Gonçalves; Cunha, Sofia; Barros, R.; et al. "Effect of dietary probiotic supplementation on growth and innate immune system in sole (Solea senegalensis Kaup, 1858) subjected to pathogenic bacteria infection and handling stress". Paper presented in IMMR | International Meeting on Marine Research 2014, 2014.
    10.3389/conf.fmars.2014.02.00019
  2. Queiroz, A.C.; Pereira, R.; Domingues, A.; Peixoto, MJ; Gonçalves, José; Ozório, R.O.A.. "Effect of seaweed supplementation on growth performance, immune and oxidative stress responses in gilthead seabream (Sparus aurata)". Paper presented in IMMR | International Meeting on Marine Research 2014, 2014.
    10.3389/conf.fmars.2014.02.00018
  3. Fonseca SB; Magalhães FA; Gravato, C; Soares, AMVM; Gonçalves J.F.M.; Peixoto, MJ; Domingues, A.; et al. "Antioxidant capacity of meagre Argyrossomus regius fed different lipid content and source, with and without selenium". Paper presented in IMMR | International Meeting on Marine Research 2014, 2014.
    10.3389/conf.fmars.2014.02.00142
  4. Brito, Francisca; Sthelio, F.; Peixoto, MJ; Domingues, A.; Damasceno-Oliveira, A.; Gonçalves, José; C. Castro, L. Filipe; Cunha, I.; Ozório, R.O.A.. "Metabolic regulation in meagre, Argyrosomus regius (Asso, 1801): Study of gene-diet interactions on lipid metabolism". Paper presented in IMMR | International Meeting on Marine Research 2014, 2014.
    10.3389/conf.fmars.2014.02.00014
  5. Magalhães, F.A.; Fonseca, S.B.; F. Pereira, Luís; Santos, M.; Ribeiro, L.; Gonçalves, José; Green, K.S.; et al. "Effects of dietary fish oil replacement by vegetable oil on the digestive enzymes activity and intestinal morphology in Meagre, Argyrosomus regius (Asso, 1801)". Paper presented in IMMR | International Meeting on Marine Research 2014, 2014.
    10.3389/conf.fmars.2014.02.00015
Journal article
  1. Mónica Lopes-Marques; M. João Peixoto; David N. Cooper; M. João Prata; Luísa Azevedo; L. Filipe C. Castro. "Polymorphic pseudogenes in the human genome - a comprehensive assessment". Human Genetics (2024): http://dx.doi.org/10.1007/s00439-024-02715-9.
    10.1007/s00439-024-02715-9
  2. Juan Dominguez; Ana I. Mendes; Ana R. Pacheco; Maria J. Peixoto; Jorge Pedrosa; Alexandra G. Fraga. "Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans". Frontiers in Microbiology 14 (2023): http://dx.doi.org/10.3389/fmicb.2023.1266261.
    10.3389/fmicb.2023.1266261
  3. Ana Isabel Mendes; Alexandra Gabriel Fraga; Maria João Peixoto; Ivo Aroso; Adhemar Longatto-Filho; Alexandra Pinto Marques; Jorge Pedrosa. "Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds". Bioengineering & Translational Medicine (2023): https://doi.org/10.1002/btm2.10504.
    10.1002/btm2.10504
  4. Maria João Peixoto. "An optimized mouse model of Staphylococcus aureus infected diabetic ulcers". BMC Research Notes (2022): http://dx.doi.org/10.1186/s13104-022-06170-5.
    10.1186/s13104-022-06170-5
  5. Mónica Lopes-Marques; Ana Rita Pacheco; Maria João Peixoto; Ana Rita Cardoso; Catarina Serrano; António Amorim; Maria João Prata; David N. Cooper; Luísa Azevedo. "Common polymorphic OTC variants can act as genetic modifiers of enzymatic activity". Human Mutation (2021): https://doi.org/10.1002/humu.24221.
    10.1002/humu.24221
  6. Fevereiro, João; Fraga, Alexandra G.; Capela, Carlos; Sopoh, Ghislain E.; Dossou, Ange; Ayelo, Gilbert Adjimon; Peixoto, Maria João; et al. "Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer". Emerging Microbes & Infections (2021): 1-8. http://dx.doi.org/10.1080/22221751.2021.1878936.
    Accepted • 10.1080/22221751.2021.1878936
  7. Peixoto, MJ; Peixoto, Maria; Peixoto, Maria. "Protective effects of seaweed supplemented diet on antioxidant and immune responses in European seabass (Dicentrarchus labrax) subjected to bacterial infection". Scientific Reports 9 16134 (2019): http://dx.doi.org/10.1038/s41598-019-52693-6.
    Published • 10.1038/s41598-019-52693-6
  8. Silva-Brito, Francisca; Timóteo, Filipa; Esteves, Ângela; Peixoto, Maria João; Ozorio, Rodrigo; Magnoni, Leonardo; Timoteo, Filipa; Esteves, Angela; Peixoto, Maria Joao. "Impact of the replacement of dietary fish oil by animal fats and environmental salinity on the metabolic response of European Seabass (Dicentrarchus labrax)". Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (2019): http://dx.doi.org/10.1016/j.cbpb.2019.04.004.
    10.1016/j.cbpb.2019.04.004
  9. Maria J. Peixoto; Leonardo Magnoni; José F. M. Gonçalves; Robert H. Twijnstra; Anake Kijjoa; Rui Pereira; Arjan P. Palstra; et al. "Effects of dietary supplementation of Gracilaria sp. extracts on fillet quality, oxidative stress, and immune responses in European seabass (Dicentrarchus labrax)". Journal of Applied Phycology (2018): https://doi.org/10.1007%2Fs10811-018-1519-x.
    10.1007/s10811-018-1519-x
  10. Peixoto, Maria; Pereira, L. F.; Peixoto, M. J.; Carvalho, P.; Sansuwan, K.; Santos, G. A.; Goncalves, J. F. M.; Ozorio, R. O. A.. "Cross-effects of dietary probiotic supplementation and rearing temperature on growth performance, digestive enzyme activities, cumulative mortality and innate immune response in seabass (Dicentrarchus labrax)". Aquaculture Nutrition 24 1 (2018): 453-460. http://dx.doi.org/10.1111/anu.12578.
    10.1111/anu.12578
  11. Peixoto, Maria; Peixoto, M. J.; Domingues, A.; Batista, S.; Goncalves, J. F. M.; Gomes, A. M.; Cunha, S.; et al. "Physiopathological responses of sole (Solea senegalensis) subjected to bacterial infection and handling stress after probiotic treatment with autochthonous bacteria". Fish & Shellfish Immunology (2018): http://www.sciencedirect.com/science/article/pii/S1050464818305898.
    https://doi.org/10.1016/j.fsi.2018.09.045
  12. Peixoto, Maria. "Effect of dietary seaweed supplementation on growth performance, antioxidant and immune responses in European seabass (Dicentrarchus labrax) subjected to rearing temperature and salinity oscillations". International Aquatic Research (2018): https://doi.org/10.1007/s40071-018-0208-3.
    10.1007/s40071-018-0208-3
  13. Peixoto, Maria; Magnoni, Leonardo J.; Salas-Leiton, Emilio; Peixoto, Maria-Joao; Pereira, Luis; Silva-Brito, Francisca; Fontinha, Filipa; et al. "Dietary electrolyte balance affects growth performance, amylase activity and metabolic response in the meagre (Argyrosomus regius).". Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (2017): https://publons.com/publon/6466618/.
    10.1016/j.cbpb.2017.03.001
  14. Peixoto, Maria Joao; Salas-Leiton, Emilio; Brito, Francisca; Pereira, Luis Ferreira; Svendsen, Jon C.; Baptista, Teresa; Pereira, Rui; et al. "Effects of dietary Gracilaria sp and Alaria sp supplementation on growth performance, metabolic rates and health in meagre (Argyrosomus regius) subjected to pathogen infection". Journal of Applied Phycology (2017): 1-15. https://publons.com/publon/10166191/.
    10.1007/S10811-016-0917-1
  15. Pereira, L. F.; Goncalves, J. F. M.; Peixoto, M. J.; Domingues, A.; Fonseca, S. B.; Magalhaes, F. A.; Santos, G. A.; et al. "Cross-effects of dietary probiotic supplementation and rearing temperature on antioxidant responses in European seabass [Dicentrarchus labrax (Linnaeus, 1758)] juveniles". Journal of Applied Ichthyology (2017): n/a-n/a. https://publons.com/publon/10166185/.
    10.1111/JAI.13256
  16. Peixoto, M.J.; Salas-Leitón, E.; Pereira, L.F.; Queiroz, A.; Magalhães, F.; Pereira, R.; Abreu, H.; et al. "Role of dietary seaweed supplementation on growth performance, digestive capacity and immune and stress responsiveness in European seabass (Dicentrarchus labrax)". Aquaculture Reports 3 (2016): 189-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962162242&partnerID=MN8TOARS.
    10.1016/j.aqrep.2016.03.005
  17. Valente, Luisa M. P.; Araujo, Mariana; Batista, Sonia; Peixoto, Maria J.; Sousa-Pinto, Isabel; Brotas, Vanda; Cunha, Luis M.; et al. "Carotenoid deposition, flesh quality and immunological response of Nile tilapia fed increasing levels of IMTA-cultivated Ulva spp". Journal of Applied Phycology 28 1 (2016): 691-701. https://publons.com/publon/7811258/.
    10.1007/S10811-015-0590-9
  18. Araujo, Mariana; Rema, Paulo; Sousa-Pinto, Isabel; Cunha, Luis M.; Peixoto, Maria Joao; Pires, Maria A.; Seixas, Fernanda; et al. "Dietary inclusion of IMTA-cultivated Gracilaria vermiculophylla in rainbow trout (Oncorhynchus mykiss) diets: effects on growth, intestinal morphology, tissue pigmentation, and immunological response". Journal of Applied Phycology 28 1 (2016): 679-689. https://publons.com/publon/7811257/.
    10.1007/S10811-015-0591-8
  19. Silva-Brito, Francisca; Magnoni, Leonardo J.; Fonseca, Sthelio Braga; Peixoto, Maria Joao; Castro, L. Filipe C.; Cunha, Isabel; de Almeida Ozorio, Rodrigo Otavio; et al. "Dietary Oil Source and Selenium Supplementation Modulate Fads2 and Elovl5 Transcriptional Levels in Liver and Brain of Meagre (Argyrosomus regius)". Lipids 51 6 (2016): 729-741. https://publons.com/publon/6466619/.
    10.1007/S11745-016-4157-6
  20. Peixoto, Maria J.; Svendsen, Jon C.; Malte, Hans; Pereira, Luis F.; Carvalho, Pedro; Pereira, Rui; Goncalves, Jose F. M.; Ozorio, Rodrigo O. A.; Peixoto, Maria. "Diets supplemented with seaweed affect metabolic rate, innate immune, and antioxidant responses, but not individual growth rate in European seabass (Dicentrarchus labrax)". Journal of Applied Phycology (2016): https://publons.com/publon/10166190/.
    10.1007/S10811-015-0736-9
  21. Ozorio, Rodrigo O. A.; Kopecka-Pilarczyk, Justyna; Peixoto, Maria J.; Lochmann, Rebecca; Santos, Ricardo J.; Santos, Goncalo; Weber, Barbara; et al. "Dietary probiotic supplementation in juvenile rainbow trout (Oncorhynchus mykiss) reared under cage culture production: effects on growth, fish welfare, flesh quality and intestinal microbiota". Aquaculture Research 47 9 (2016): 2732-2747. https://publons.com/publon/2086390/.
    10.1111/ARE.12724
  22. Coimbra, Ana M.; Peixoto, Maria Joao; Coelho, Ines; Lacerda, Ricardo; Carvalho, Antonio Paulo; Gesto, Manuel; Lyssimachou, Angeliki; et al. "Chronic effects of clofibric acid in zebrafish (Danio rerio): A multigenerational study". Aquatic Toxicology (2015): https://publons.com/publon/5627777/.
    10.1016/J.AQUATOX.2015.01.013
  23. Peixoto Maria João; Abreu Helena; Domingues Andreia; Queiroz Augusto; Pereira Luís; Magalhães Fernando; Gonçalves José; Reis Pedro; Ozorio Rodrigo. "SEABIOPLAS project Seaweed co-products as micro-additives in fish feed". Front. Mar. Sci. 1 (2014): http://dx.doi.org/10.3389/conf.fmars.2014.02.00017.
    10.3389/conf.fmars.2014.02.00017
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/05/01 - 2023/06/28 "Redes imunometabólicas durante as interações entre células dendríticas e Leishmania"
Supervisor
Biologia Aplicada (Degree)
Universidade do Minho, Portugal
2023/05/01 - 2023/06/28 "Unravelling the Impact of Glucose Availability on Glycogen and Acetate Production in Macrophages Infected with Leishmania donovani : implications for Leishmaniasis Pathogenesis"
Supervisor
Bioquímica (Degree)
Universidade do Minho, Portugal
2023/04/15 - 2023/06/15 "Examining the Influence of Glucose Deprivation on Macrophage Metabolism During Leishmania donovani Infection: Insights into Glycogen and Acetate Production Dynamics"
Co-supervisor of Chinemerem Benita Agughasi
Medicina (Degree)
Universidade do Minho, Portugal
2023/04/20 - 2023/06/02 "Immunometabolic networks in the regulation of visceral Leishmaniasis: effect of glycolysis modulation on Dendritic cells function during Leishmania infantum infection."
Supervisor
Doutoramento em Ciências da Saúde (Specialization course)
Universidade do Minho, Portugal
2023/05/01 - 2023/05/28 "Immunometabolic networks in the regulation of visceral Leishmaniasis"
Supervisor of Mariana Loureiro de Oliveira Faria Ferreira
Biologia Aplicada (Degree)
Universidade do Minho, Portugal
2021/01/10 - 2021/02/21 "Metabolic requirements in Buruli ulcer – the role of glucose in the progression of Mycobacterium ulcerans infection"
Co-supervisor
Doutoramento em Ciências da Saúde (Specialization course)
Universidade do Minho, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/04/01 "Avaliação da eficácia de novas abordagens terapêuticas para lesões ulcerativas infetadas"
(Thesis) Main arguer
Maria Inês Fernandes Monteiro (Other)
Universidade de Trás-os-Montes e Alto Douro, Portugal