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Ana Mendes-Frias obtained her bachelor degree in Biochemistry in 2014 and the master degree in Clinical Analysis in 2016, both by University of Coimbra. Currently, she attends the PhD in Health Sciences in University of Minho. Ana Mendes-Frias is developing her thesis in the Life and Health Sciences Research Institute (ICVS) supervised by Dr. Ricardo Silvestre and Dr. Luís Lopes. Her project aims to unravel the sex-based differences of branched-chain amino acids supplementation in ulcerative colitis. During her Phd, Ana Mendes-Frias collaborated in different project leading to the publication of 16 articles in several international peer-reviewed journals and presented her results at national and international conferences (poster and oral communication presentation). Ana Mendes-Frias also co-supervised 3 bachelor projects and 1 master thesis.
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Identification

Personal identification

Full name
ANA ISABEL MENDES FRIAS

Citation names

  • Mendes-Frias, Ana

Author identifiers

Ciência ID
8E1E-327A-594D

Email addresses

  • id8209@alunos.uminho.pt (Professional)

Telephones

Telephone
  • 253604834 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS): School of Medicine; University of Minho. Campos de Gualtar , 4710-057, Braga, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2024/02/28 - 2024/03/22
Concluded
 3rd Advanced Course on Fluorescence Microscopy & Image Analysis (Outros)
CICSUBI - Centro de Investigação em Ciências da Saúde Universidade da Beira Interior, Portugal
2018/09 - 2024
Ongoing
 Health Sciences (Doutoramento)
Universidade do Minho, Portugal
"Therapeutic potential of branched-chain amino acids and succinate in ulcerative colitis." (THESIS/DISSERTATION)
2019/01 - 2019/02
Concluded
 FELASA C - Laboratory Animal Science (Outros)
Universidade do Minho, Portugal
2014/09 - 2016/07
Concluded
 Clinical Analysis (Mestrado integrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 16
2011/09 - 2014/07
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Breast cancer: Dose response curves of cell lines to radiotherapy" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/07 - 2024/08 Visiting Researcher (Research) Luxembourg Institute of Health Department of Infection and Immunity, Luxembourg
2014/07 - 2014/08 Research Trainee (Research) Instituto Português do Sangue e da Transplantação (IPST), Portugal
2014/01 - 2014/06 Research Trainee (Research) CNC.IBILI, Portugal
2013/07 - 2013/08 Research Trainee (Research) CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
2018 - Current PhD Student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/03 - 2018/08 In Process Control (quality control of the production process) Labialfarma, Portugal
2015/12 - 2016/05 Master Student Laboratório S. José - IDEALMED , Portugal
Projects

Grant

Designation Funders
2024/10 - 2025/03 Financiamento FCT das Unidades de I&D
UIDP/50026/2020
Master Student Fellow
Ongoing
2021/03 - 2024/09 Elucidation of the Functional Roles of Lipid Metabolism During Visceral Leishmaniasis
PTDC/CVT-CVT/4808/2020
Researcher
Ongoing
2021/09 - 2024/08 Sex-based differences of branched-chain amino acids supplementation in ulcerative colitis
2021.07836.BD
PhD Student Fellow
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/09 - 2021/05 Therapeutic potential of branched-chain amino acids and succinate in ulcerative colitis.
UMINHO/BD/57/2018 (Projeto: NORTE-08-5369-FSE-000041)
PhD Student Fellow
Laboratório Associado ICVS 3B's, Portugal
Concluded
Outputs

Publications

Conference poster
  1. Silva, Ana; Azevedo, Ricardo; Mendes-Frias, Ana ; Baltazar, Fátima; Afonso, Julieta. "Estudo e manipulação da simbiose metabólica entre células de carcinoma urotelial da bexiga e fibroblastos associados". Paper presented in 6º Encontro Nacional de Jovens Investigadores em Oncologia, Liga Portuguesa contra o Cancro, Porto, 2024.
  2. Almeida-Nunes, DL; Mendes-Frias, Ana ; Nunes, Mariana; Ferreira, Verónica; Lobo, Cláudia; Monteiro, Paula; Abreu, Miguel Henriques; et al. "Presence of exhausted lymphocytes in the ascitic microenvironment of ovarian cancer patients: implications for immune dysfunction". Paper presented in VII iBiMED Symposium, Universidade de Aveiro, 2024.
  3. Mendes-Frias, Ana; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Duarte, Iola F.; Gaifem, Joana; Torrado, Egídio; et al. "Branched-Chain Amino Acids in Ulcerative Colitis: friend or foe?". Paper presented in XLIX Annual Meeting of the Portuguese Society for Immunology,, 2024.
  4. Araújo, Marta; Mendes-Frias, Ana; Micheli, Consuelo; Torrado, Egídio; Silveste, Ricardo. "Deciphering the Role of Lipid Accumulation in Macrophages during Leishmania Infection". Paper presented in Pathogen immunity and signaling EMBO Meeting, San servolo, Veneza, 8th-12th, 2024.
  5. Micheli, Consuelo; Mendes-Frias, Ana ; Araújo, Marta; Rodrigues, Fernando; Carvalho, Agostinho; Vilanova, Manuel; Silvestre, Ricardo; Castro, António Gil; Torrado, Egídio. "The key role of alveolar macrophages in shaping the CD4+ T cell activation and control os M. tuberculosis infection". Paper presented in Pathogen immunity and signaling EMBO Meeting, San servolo, Veneza, 8th-12th, 2024.
  6. Mendes-Frias, Ana ; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Gaifem, Joana; Torrado, Egídio; Lopes, Luís; Silvestre, Ricardo. "Unraveling the dynamic effect of branched-chain amino acids in the gut: the influence of sex". Paper presented in EMBO Young Scientists' Forum, 2023.
  7. Araújo, Marta; Moreira, Diana; Mesquita, Inês; Ferreira, Carolina; Mendes-Frias, Ana; Barros-Carvalho, Sónia; Dinis-Oliveira, Ricardo Jorge; et al. "Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis". Paper presented in EMBO Young Scientists' Forum, 2023.
  8. Mendes-Frias, Ana; Vieira, Maria C.; Araújo, Marta; Micheli, Consuelo; Gaifem, Joana; Torrado, Egídio; Lopes, Luís; Silveste, Ricardo. "Unraveling the dynamic effect of branched-chain amino acids in the gut". Paper presented in Retreat for postgraduate students at the School of Medicine, 2023.
  9. Mendes-Frias, Ana ; André Santa Cruz; Marne Azarias-da-Silva; Sónia André; Ana Isabel Oliveira; Olga Pires; Marta Mendes; et al. "Blood CD8+ß7+ T cells and serum IgA humoral response against SARS-CoV-2 antigens characterize Post COVID-19 condition at six months post infection.". Paper presented in XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  10. Almeida-Nunes, Diana Luísa; Mendes-Frias, Ana ; Dinis-Oliveira, Ricardo Jorge; Silvestre, Ricardo; Ricardo, Sara. "The influence of tumor microenvironment immunein ovarian cancer ascites". Paper presented in The Structural Microenvironment: Breaking down the walls of cancer, 2023.
  11. Mendes-Frias, Ana ; Araújo, Marta; Silvestre, Ricardo. "Characterization of Leishmania donovani infection in the gut: from the epithelial barrier to the immune system". Paper presented in Leishmaniasis 2022, 2022.
  12. Mendes-Frias, Ana ; Gaifem, Joana; Lopes, Luís; Silvestre, Ricardo. "Unraveling the dinamic effect of Branched Chain Amino Acids in the gut". Paper presented in Annual Meeting of Portuguese Society of Immunology, 2022.
  13. Almeida-Nunes, Diana Luísa; Mendes-Frias, Ana; Dinis-Olveira, Ricardo Jorge; Silvestre, Ricardo; Ricardo, Sara. "The influence of tumor microenvironment immunein ovarian cancer ascites". Paper presented in I Congresso Internacional da TOXRUN, 2022.
  14. Almeida-Nunes, Diana Lua; Mendes-Frias, Ana ; Dinis-Oliveira, Ricardo Jge; Silvestre, Ricardo; Ricardo, Sara. "Immune tumor microenvironment of ovarian cancer ascites". Paper presented in The Structural Microenvironment: Breaking down the walls of cancer, 2022.
  15. Mendes-Frias, Ana ; Gaifem, Joana; Lopes, Luís; Silvestre, Ricardo. "Unraveling the dinamic effect of Branched Chain Amino Acids in the gut". Paper presented in Annual Meeting of Portuguese Society of Immunology (online), 2021.
Journal article
  1. Relvas, Marta; Mendes-Frias, Ana ; Gonçalves, Maria; Salazar, Filomena; López-Jarana, Paula; Silvestre, Ricardo; Viana da Costa, Alexandra. "Salivary IL-1ß, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity". International Journal of Molecular Sciences 25 15 (2024): 8401. http://dx.doi.org/10.3390/ijms25158401.
    10.3390/ijms25158401
  2. Mendes-Frias, Ana; Moreira, Marta; Vieira, Maria C.; Gaifem, Joana; Costa, Patrício; Lopes, Luís; Silvestre, Ricardo. "Akkermansia muciniphila and Parabacteroides distasonis as prognostic markers for relapse in ulcerative colitis patients". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1367998.
    10.3389/fcimb.2024.1367998
  3. Barbosa-Matos, Catarina; Borges-Pereira, Caroline; Libório-Ramos, Sofia; Fernandes, Raquel; Oliveira, Marcela; Mendes-Frias, Ana ; Silvestre, Ricardo; et al. "Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis". Respiratory Research 25 1 (2024): http://dx.doi.org/10.1186/s12931-024-02884-1.
    10.1186/s12931-024-02884-1
  4. Gaifem, Joana; Mendes-Frias, Ana ; Wolter, Mathis; Steimle, Alex; Garzón, Maria Jose; Ubeda, Carles; Nobre, Clarisse; et al. "Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut". mBio 15 4 (2024): http://dx.doi.org/10.1128/mbio.00078-24.
    10.1128/mbio.00078-24
  5. Araújo, Marta; Moreira, Diana; Mesquita, Inês; Ferreira, Carolina; Mendes-Frias, Ana; Barros-Carvalho, Sónia; Dinis-Oliveira, Ricardo Jorge; et al. "Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis". Immunology 170 4 (2023): 510-526. http://dx.doi.org/10.1111/imm.13686.
    10.1111/imm.13686
  6. Azarias Da Silva, Marne; Nioche, Pierre; Soudaramourty, Calaiselvy; Bull-Maurer, Anne; Tiouajni, Mounira; Kong, Dechuan; Zghidi-Abouzid, Ouafa; et al. "Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13". Science Advances 9 31 (2023): http://dx.doi.org/10.1126/sciadv.adg2122.
    10.1126/sciadv.adg2122
  7. Mendes-Frias, Ana ; Santa Cruz, André; Azarias-da-Silva, Marne; André, Sónia; Oliveira, Ana Isabel; Pires, Olga; Mendes, Marta; et al. "Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+ß7 integrin+ T cells and anti-SARS-CoV-2 IgA response". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37368-1.
    10.1038/s41467-023-37368-1
  8. Tavares, Matheus; Sousa-Filho, Jorge Carlos; Machado, Ian Alves; Gonçales, Relber Aguiar; Antunes, Daniela; Mendes-Frias, Ana ; Silvestre, Ricardo; et al. "Development of a Versatile Toolbox for Genetic Manipulation of Sporothrix brasiliensis". Microbiology Spectrum (2023): http://dx.doi.org/10.1128/spectrum.04564-22.
    10.1128/spectrum.04564-22
  9. Relvas, Marta; Silvestre, Ricardo; Gonçalves, Maria; Cabral, Cristina; Mendes-Frias, Ana ; Monteiro, Luís; Viana da Costa, Alexandra. "Analysis of Salivary Levels of IL-1ß, IL17A, OPG and RANK-L in Periodontitis Using the 2017 Classification of Periodontal Diseases—An Exploratory Observational Study". Journal of Clinical Medicine 12 3 (2023): 1003. http://dx.doi.org/10.3390/jcm12031003.
    10.3390/jcm12031003
  10. Mendes-Frias, Ana ; Gallo, Valentina; Iacobelli, Valentina; Gentile, Roberta; Antonini, Giovanni; Silvestre, Ricardo; Iacobelli, Stefano. "Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-20852-x.
    10.1038/s41598-022-20852-x
  11. da Silva-Ferreira, Sara; Duarte-Oliveira, Cláudio; Antunes, Daniela; Barbosa-Matos, Catarina; Mendes-Frias, Ana ; Torrado, Egídio; Costa, Sandra; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.1005839.
    10.3389/fcimb.2022.1005839
  12. Almeida-Nunes, Diana Luísa; Mendes-Frias, Ana ; Silvestre, Ricardo; Dinis-Oliveira, Ricardo Jorge; Ricardo, Sara. "Immune Tumor Microenvironment in Ovarian Cancer Ascites". International Journal of Molecular Sciences 23 18 (2022): 10692. http://dx.doi.org/10.3390/ijms231810692.
    10.3390/ijms231810692
  13. André, Sonia; Azarias da Silva, Marne; Picard, Morgane; Alleaume-Buteau, Aurélie; Kundura, Lucy; Cezar, Renaud; Soudaramourty, Calaiselvy; et al. "Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients". Cell Death and Disease 13 8 (2022): http://dx.doi.org/10.1038/s41419-022-05190-0.
    10.1038/s41419-022-05190-0
  14. André, Sonia; Picard, Morgane; Cezar, Renaud; Roux-Dalvai, Florence; Alleaume-Butaux, Aurélie; Soundaramourty, Calaiselvy; Cruz, André Santa; et al. "T cell apoptosis characterizes severe Covid-19 disease". Cell Death & Differentiation (2022): http://dx.doi.org/10.1038/s41418-022-00936-x.
    10.1038/s41418-022-00936-x
  15. Mendes-Frias, Ana; Santa Cruz, André; Oliveira, Ana Isabel; Dias, Luís; Matos, Ana Rita; Carvalho, Alexandre; Capela, Carlos; et al. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Frontiers in Immunology 12 (2021): 263. http://dx.doi.org/10.3389/fimmu.2021.613422.
    Open access • Published • 10.3389/fimmu.2021.613422
  16. Mendes-Frias, Ana; Santos-Lima, Bruno; Furtado, Danielle Zildeana Sousa; Ruperez, Francisco J.; Assunção, Nilson Antonio; Matias, Maria João; Gomes, Vânia; et al. "Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes". Journal of Translational Autoimmunity 3 (2020): http://dx.doi.org/10.1016/j.jtauto.2020.100056.
    Published • 10.1016/j.jtauto.2020.100056
Thesis / Dissertation
  1. Frias, Ana Isabel Mendes. "Relatório de estágio : mestrado em análises clínicas". Master, 2016. http://hdl.handle.net/10316/37044.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/24 Branched-Chain amino acids in ulcerative colitis: a friend or a foe? VII iBiMED symposium
iBiMED - Universidade de Aveiro (Aveiro, Portugal)
2024/02/05 Sex-based differences of branched-chain amino acids supplementation in ulcerative colitis Ciência Falada
ICVS

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09 - 2024/11 Biomarcadores para a caracterização da Doença Hepática Crónica Avançada descompensada
Co-supervisor of João Martins
 Mestrado integrado em Medicina (Master)
Universidade do Minho, Portugal
2024/04 - 2024/06 Caracterização do impacto do microbioma intestinal no sistema imunológico
Co-supervisor of Claudia Oliveira
Laboratório Associado ICVS 3B's, Portugal
2024/04 - 2024/06 Avaliação das diferenças associadas ao sexo em colite ulcerosa
Co-supervisor of Cláudia Silva
Laboratório Associado ICVS 3B's, Portugal
2024/04 - 2024/06 Caracterização do impacto do microbioma intestinal no epitélio intestinal
Co-supervisor of Marco Alves
Laboratório Associado ICVS 3B's, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/10/15 - Current Single Cell Multiomics
Workshop
 Single Cell Multiomics
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/06/07 - Current LIPIDS AND CELL PLASTICITY SYMPOSIUM
Symposium
 LIPIDS AND CELL PLASTICITY SYMPOSIUM
Universidade de Aveiro Instituto de Biomedicina, Portugal
2024/02/05 - Current Cancro em Perspetiva
Seminar
 Cancro em Perspetiva
2024/02 - Current Como Encontrar Empregos que não se Veem / how to find jobs that can not be seen
Workshop
 Como Encontrar Empregos que não se Veem
2023/07/11 - 2023/07/13 CellMeD - Meeting in Cellular membrane dynamics
Congress
 CellMeD - Meeting in Cellular membrane dynamics
International Iberian Nanotechnology Laboratory, Portugal
2022/05/02 - 2022/05/03 Full Spectrum Flow Cytometry Course
Seminar
 Full Spectrum Flow Cytometry Course
Instituto Politécnico do Porto, Portugal
2021/04/22 - 2021/04/24 Orpheus Conference 2021 - Online (Braga)
Conference
 Orpheus Conference 2021 - online event
Universidade do Minho, Portugal
2019/07/22 - 2019/07/26 Summer School on Epithelial Systems: Physiology and Pathophysiology
Seminar
 Summer School on Epithelial Systems: Physiology and Pathophysiology
BioISI - Biosystems & Integrative Sciences Institute, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020/04 - Current Membro da Comissão de avaliação e acreditação da Agência de Avaliação e Acreditação do Ensino Superior (A3ES) para o ciclo de estudos de doutoramento, na qualidade de aluna.
Evaluator
 Agência Nacional de Avaliação e Acreditação (A3ES), Portugal