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Ana Paula Silva obtained her B.Sc. degree in Biology in July 1998 at the Faculty of Sciences and Technology, University of Coimbra, Portugal, and in January 2003 she obtained her doctorate degree in Cellular Biology at the same University. During her PhD, AP Silva worked at the Center for Neuroscience and Cell Biology (CNC), Coimbra, and at the Anatomy and Neurobiology Department, Odense University, Denmark (Lab of Professor Jens Zimmer), in a project entitled "Neurotoxicity and neuroprotection in the hippocampus: role of neuropeptide Y receptors". During this period she received an Award from "Calouste Gulbenkian Foundation" and an Honorable Mention from "Professor Francisco Pulido Valente Foundation". Afterwards, AP Silva started working as a postdoctoral research fellow at the CNC and at the Neuropharmacology Laboratory, Faculty of Health and Life Sciences, University Pompeu Fabra, Barcelona, Spain (Lab of Professor Rafael Maldonado) in the scientific project entitled "Neuroprotective effect of neuropeptide Y in excitotoxicity and in temporal lobe epilepsy". On August 2005, AP Silva got a research position at the Faculty of Medicine, University of Coimbra, Portugal (FMUC), and started to investigate the impact of psychostimulants in the Central Nervous System. Since 2016 she is also Professor of Applied Investigation II (semiannual curricular unit), Integrated Master in Medicine at the Faculty of Medicine, University of Coimbra (FMUC), Portugal. She also participates as a teacher in several Master and PhD programmes, as well as in the supervision of laboratory rotations of both master and undergraduate students. AP Silva is currently a Principal Investigator at FMUC, a member of the Scientific Committee of Coimbra Institute for Clinical and Biomedical Research (iCBR), the coordinator of the "Neuropharmacology and Neuropsychiatry" group of the same Institute, and a member of the Animal Welfare and Ethics Committee (ORBEA) of FMUC. She is also a member of the Center for Innovative Biomedicine and Biotechnology (CIBB; CNC-iCBR consortium). Moreover, AP Silva was a member of the Faculty of Medicine Council between 2015 and 2019, and the coordinator of the Research Office (GAI) of the same Institution between 2012 and 2016. Ana Paula Silva published 66 articles in peer-review journals and 4 section(s) of books. Information based on Scopus: h-index: 36; 3,107 citations. She participates and/or participated as Principal investigator in 9 project(s) and as a team member in 17 project(s). She supervised 7 PhD thesis (+ 2 ongoing) ; Supervised 23 MSc dissertations (+ 3 ongoing); Supervised 4 postdoctoral fellows and several national and international undergraduate students. AP Silva has more that 200 participations in national and international meetings with both poster and oral communications. She received 9 awards and/or honors and organized 25 event(s). Besides her scientific career, she has been actively participating in several dissemination initiatives for the general public (European Researchers Night, Brain Awareness week, Science and Technology Week, University Student Associations). Principal keywords: addiction, astrocytes, attention-deficit/hyperactivity disorder (ADHD), blood-brain barrier (BBB), methamphetamine, methylphenidate, microglia, neuroinflammation, neuropeptide Y, oxidative stress, retina, traumatic brain injury.
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Identification

Personal identification

Full name
Ana Paula Pereira da Silva Martins

Author identifiers

Ciência ID
8F12-BE92-377E

Email addresses

  • apmartins@fmed.uc.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Health Sciences - Substance Abuse
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree Classification
2003/02/01 - 2005/08/31
Concluded
 Neuroprotective effect of neuropeptide Y in excitotoxicity and in temporal lobe epilepsy (Pós-doutoramento)
Major in Health Sciences, Neurosciences
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/11/02 - 2004/11/12
Concluded
 FELASA accreditation (Federation for Laboratory Animal Science Associations) (III Curso de Experimentação Animal) (Pós-Graduação)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
1999/01/01 - 2003/01/07
Concluded
 Biologia (Biologia Celular) (Doutoramento)
Major in Cellular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Neurotoxicity and neuroprotection in the hippocampus: role of neuropeptide Y receptores" (THESIS/DISSERTATION)
 Maximum Classification (Distinção e Louvor, in PT)
1993/09/01 - 1998/09/30
Concluded
 Biologia (Licenciatura)
Major in Research, Cellular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2016/06/01 - Current Principal Investigator (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2005/09/01 - 2016/05/31 Auxiliary Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2003/02/01 - 2005/08/31 Postdoc (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020/01/02 - Current Member of Animal Welfare Committee (Faculty of Medicine, University of Coimbra) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/01 - Current Member of the iCBR Scientific Committee (Coimbra Institute for Clinical and Biomedical Research) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/01 - Current Coordinator of the group "Neuropharmacology and Neuropsychiatry" from the Coimbra Institute for Clinical and Biomedical Research (iCBR) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/01 - 2019/03/19 Member of the Faculty of Medicine Council Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/02/01 - 2016/11/30 Coordinator of the Research Office (GAI) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2016/09/01 - Current Professor of Applied Investigation II (semiannual curricular unit), Integrated Master in Medicine Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2003/01/01 - 2003/12/31 Coupling of neuropeptide Y receptor activation to intracellular mechanisms mediating glutamate release in hippocampal neurons (PI)
Gulbenkian Programme of Investigation Stimulus, Intracellular Communication field
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação Calouste Gulbenkian
Concluded

Contract

Designation Funders
2023/01/01 - Current Lets Talk about Children (Team Member)
101101249
Researcher
Mielenterveysseura, Finland

Universidade de Coimbra, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
European Commission Seventh Framework Programme for Research and Technological Development Health
Ongoing
2021/09/01 - 2024/09/30 Cerebrovascular hypothesis of stress-induced behavioral alterations (PI)
73/20
Principal investigator
Universidade de Coimbra, Portugal
 Fundação Bial
Ongoing
2022/01/01 - 2023/12/31 Neutrophils infiltration through blood-brain barrier in traumatic brain injury: Role of CXCL8 (Team member)
EXPL/MED-PAT/0660/2021
Researcher
Faculty of Medicine, University of Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2019/01/01 - 2022/12/31 Brain metastases: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment (BRAIN_METS) (Team member)
POCI-01-0145-FEDER-030625
PTDC/MED-ONC/30625/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade de Coimbra, Portugal
Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2018/08/19 - 2021/12/31 Alemtuzumab therapy in Multiple Sclerosis: tracking immune cell trafficking, induced molecular mechanisms and aftermath effects (Team member)
GZ-2017-11730
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Sanofi Produtos Farmacêuticos Lda
Concluded
2018/07/01 - 2021/06/30 Psychostimulant-induced neuroinflammation: new insight in the crosstalk between microglia, astrocytes and neurons (Team member)
PTDC/SAU-TOX/30647/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05/01 - 2020/12/31 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy (CANCERSTEM) (Team member)
Aviso 03/SAICT/2015
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Portugal 2020
Ongoing
2013/05/01 - 2015/04/30 Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder (PI)
PTDC/NEU-OSD/0312/2012
Principal investigator
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/04/30 Neuropeptide Y system: a new potential therapeutic target in diabetic retinopathy (Team member)
PTDC/NEU-OSD/1113/2012
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/02/28 DPP-IV inhibitors and GLP-1 as potential therapeutic options for the treatment of diabetic retinopathy: novel insights into the mechanisms of action (Team member)
EFSD/GSK 2010
Researcher
Universidade de Coimbra, Portugal
 European Foundation for the Study of Diabetes/GlaxoSmithKline
Concluded
2010/04/01 - 2013/09/30 Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation (PI)
PTDC/SAU-FCF/098685/2008
Principal investigator
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/03/31 Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis: new targets for brain repair therapies. (Team member)
PTDC/SAU-NEU/101783/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Science and Technology Foundation, Ministry of Education and Science
Concluded
2010/04/01 - 2013/03/31 Histamina versus anti-histamínicos: novos moduladores da neurogénese? (Team member)
PTDC/SAU-NEU/104415/2008
Provided by PTCRIS: 104415
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Unravelling the causes and consequences of methamphetamine-induced impairment of adult hippocampal neurogenesis: is neuropeptide Y a therapeutic tool? (PI)
APS911
Principal investigator
Universidade de Coimbra Faculdade de Medicina, Portugal
 Faculty of Medicine, University of Coimbra
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/05/01 - 2010/09/30 Microglial and Neuronal Changes in the Hippocampus Induced by Methamphetamine: Role of Pro-inflammatory Cytokines and Neuropeptide Y (PI)
PTDC/SAU-FCF/67053/2006
Principal investigator
Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/05/01 - 2010/04/30 Subventricular zone stem cells as a tool for brain repair in temporal lobe epilepsy (Team member)
PTDC/SAU-NEU/68465/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Science and Technology Foundation, Ministry of Education and Science
Concluded
2009/01/01 - 2009/10/31 The effect of methamphetamine on mouse subventricular zone neurogenesis (PI)
GAI 04/09
Principal investigator
Universidade de Coimbra Faculdade de Medicina, Portugal
 Faculty of Medicine, University of Coimbra
Concluded
2008/01 - 2008/10 IMPACT OF METHAMPHETAMINE ON THE BLOOD-BRAIN BARRIER FUNCTION (PI)
GAI 02/08
Principal investigator
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
2005/09/01 - 2008/08/31 Neo-neurogenesis and Microglia in Temporal Lobe Epilesy: Role of Pro-inflammatory Cytokines and Neuropeptide Y in Neuroprotection of New Neurons (Team member)
POCTI/SAU-NEU/58492/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2008/06/30 Biochemical and Behavioural Study of Opioid-Cocaine Interactions
POCI/SAU-FCF/58330/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2007/12/31 Biochemical and behavioural study of opioid-cocaine interactions (Team member)
POCTI/SAU-FCF/58330/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/01/01 - 2006/10/31 Effect of methamphetamine on the levels of glutamate ionotropic receptors in the striatum, cortex and hippocampus (PI)
GAI 23/06
Principal investigator
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
2003/09/01 - 2006/08/31 Immunological and functional identification of ionotropic presynaptic glutamate receptors (Team member)
POCTI/FCB/46804/2002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/09/01 - 2006/08/31 Neuroprotective effect of neuropeptide Y in excitotoxicity and temporal lobe epilepsy (Team member)
POCTI/NSE/46848/2002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2001/04/01 - 2004/03/31 Neurotoxicity mediated by AMPA and kainate receptors in the hippocampus: Role of nitric oxide (Team member)
POCTI/NSE/35875/99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000/10 - 2003/09 Mechanisms of presynaptic kainate receptor inhibition of glutamate and GABA release: Role of epileptogenesis (Team member)
POCTI/36491/99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Leitão, Ricardo Alexandre; Silva, Ana Paula. "THE IMPACT OF DRUGS OF ABUSE ON BLOOD-BRAIN BARRIER". In Advances in Brain Vascular Research, 146-175. United Kingdom: Cambridge Scholars Publishing, 2020.
    Accepted
  2. Xapelli, Sara; Silva, Ana Paula. "Neuropéptidos". In Neurociências, edited by Rego, Ana Cristina, 213-230. LIDEL, 2017.
    Published
  3. Gonçalves, Joana; Silva, Ana Paula. "Methamphetamine and the JAK/STAT Pathway". In Neuropathology of Drug Addictions and Substance Misuse, edited by Victor R Preedy, 147-143. Elsevier, 2016.
    Published • 10.1016/b978-0-12-800212-4.00014-5
  4. Leitão, Ricardo Alexandre; Coelho-Santos, Vanessa; Silva, Ana Paula. "Methamphetamine and the Blood-Brain Barrier". In Neuropathology of Drug Addictions and Substance Misuse, 155-168. Elsevier, 2016.
    Published • 10.1016/b978-0-12-800212-4.00015-7
Conference abstract
  1. Sanches, Eliane (3D18-270B-D531); Boia, Raquel; Leitão, Ricardo Alexandre; Martins, João; Madeira, Maria H.; Fontes-Ribeiro, Carlos A; Ambrósio, António Francisco; Fernandes, Rosa; Silva, Ana Paula. "Impact of methylphenidate on the retina in control and ADHD conditions". Paper presented in SPF Meeting 2021, Lisboa (online), 2021.
    Published
  2. Carvalho, Rita; Cônde, Inês; Santos, Liliana; Leitão, Ricardo Alexandre; Gomes, Célia; Silva, Ana Paula; Paredes, Joana; Ribeiro, Ana. "Characterization of the secretome profile in brain metastic breast cancer cells". Paper presented in 2nd joint EACR-MRS conference - Seed and Soil: mechanisms of metastasis, Berlin, 2019.
    Published
  3. Socodato, Renato; Portugal, Camila; Canedo, Teresa; Henriques, JF; Vaz, JF; Magalhães, J; Silva, CM; et al. "RhoA signaling in microglia and the impact for neurodegeneration". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019.
    Published
  4. Portugal, Camila; Socodato, Renato; Canedo, Teresa; Henriques, JF; Silva, CM; Magalhães, J; Coelho-Santos, Vanessa; et al. "Profilin-1 deficiency specifically in microglia leads to microglial disfunction, blood-brain barrier dysfunction and changes in mice behavior". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019.
    Published
  5. Martins, Beatriz C.R.; Novo, João P.; Malva, João O.; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula; Pereira, Frederico C.; Oriá, Reinaldo B.. "Mercurymemory: the effect of methylmercury exposure in microglia-mediated neuroinflammation". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
    Published
  6. Leitão, Ricardo Alexandre; Ventura, Fabiene; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Impact of traumatic brain injury on astrocytes: role of neuropeptide Y.". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019.
    Published • 10.4271/2015-01-1439
  7. Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo Alexandre; Silva, Ana Paula; Cai, Ying; Abrulhosa, Antero; Silva, Alcino J.; Castelo-Branco, Miguel. "Glutamate/GABA- glutamine cycle imbalance in a mouse model of autism spectrum disorder: relationship to glial reactivity.". Paper presented in Neuroscience 2018, San Diego, 2018.
    Published
  8. Leitão, Ricardo Alexandre; Ventura, Fabiana; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Endothelial cell dysfunction induced by methamphetamine: role of neuropeptide Y system.". Paper presented in 11th FENS 2018 - Forum of European Neuroscience, Berlim, 2018.
    Published
  9. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo Alexandre; Gomes, Célia; Rito, Manuel; et al. "Neurovascular unit alterations triggered by methylphenidate: outcome on memory performance.". Paper presented in 11th FENS 2018 - Forum of European Neuroscience, Berlim, 2018.
    Published
  10. Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo Alexandre; Cai, Y; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. "The excitation/inhibition enigma in a mouse model of the autism spectrum disorder: evidence for distinct phenotypes of hippocampus and prefrontal cortex.". Paper presented in 11th FENS 2018 - Forum of European Neuroscience, Berlim, 2018.
    Published
  11. Silva, Ana Paula; Couto, Marina; Coelho-Santos, Vanessa,; Fontes-Ribeiro, Carlos A.; Gomes, Célia. "Crosstalk between glioblastoma and microglial cells in blood-brain barrier function: role of interleukin-6.". Paper presented in 11th FENS 2018 - Forum of European Neuroscience, Berlin, 2018.
    Published
  12. Silva, Ana Paula; Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Leitão, Alexandre; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.. "Unravelling the impact of methylphenidate on neurogliovascular function: implications for memory performance". Paper presented in XIII European Meeting on Glial Cells in Health and Disease, Edinburgh, 2017.
    Published
  13. Leitão, Ricardo Alexandre; Cardoso, Filipa L.; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Neurogliovascular unit dysfunction induced by methamphetamine: protective role of parthenolide". Paper presented in XIII European Meeting on Glial Cell Function in Health and Disease, Edinburgh, 2017.
    Published
  14. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Central effects of chronic methylphenidate treatment in control and hyperactive rats: neuroinflammation and blood-brain barrier.". Paper presented in Neuroscience 2016, San Diego, 2016.
    Published
  15. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Blood-brain barrier dysfunction induced by chronic methylphenidate treatment: control vs. hyperactive rats". Paper presented in 41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kusadasi, 2016.
    Published
  16. Silva, Ana Paula; Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.. "Methylphenidate promotes brain endotelial hyperpermeability: in vitro and animal studies.". Paper presented in 10th FENS 2016 - Forum of European Neuroscience, Copenhagen, 2016.
    Published
  17. Leitão, Ricardo Alexandre; Cardoso, Filipa L.; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Protective effect of parthenolide in methamphetamine-induced neuroinflammation and neurovascular dysfunction". Paper presented in 10th FENS 2016 - Forum of European Neuroscience, Copenhagen, 2016.
    Published
  18. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Aquaporin 4 is involved in brain edema and blood-brain barrier disruption induced by methamphetamine.". Paper presented in XII European Meeting on Glial Cells in Health and Disease (Bilbao, Spain), 2015.
    Published
  19. Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Rito, Manuel; Barbosa, Marcos; Couraud, Pierre-Olivier; Romero, Ignacio; et al. "Unravelling the effect of methylphenidate on human brain endothelial cells.". Paper presented in 5th ADHD Congress 2015 - World Federation of ADHD, Glasgow, 2015.
    Published
  20. Gonçalves, Joana; Leitão, Ricardo Alexandre; Ambrosio, Emilio; Silva, Ana Paula. "Methamphetamine self-administration induces blood-brain barrier dysfunction in the rat hippocampus.". Paper presented in 9th IBRO World Congress of Neuroscience, Rio de Janeiro, 2015.
    Published
  21. Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa L.; Palmela, Inês; Rito, Manuel; Barbosa, Marcos; Brito, Maria Alexandra; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of nuclear factor-kappa B signalling in methamphetamine-induced blood-brain barrier dysfunction.". Paper presented in 27th European College of Neuropsychopharmacology, Berlin, 2014.
  22. Gonçalves, Joana; Baptista, Sofia; Olessen, MO; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Woldbye, David P.; Silva, Ana Paula. "Involvement of hippocampal neuropeptide Y system in methamphetamine-induced memory impairment: the role of NPY Y2 receptors". Paper presented in 38th FEBS Congress, Saint Petersburg, 2013.
  23. Gonçalves, Joana; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Silva, Ana Paula. "Neuropeptide Y Y2 receptors prevent methamphetamine-mediated cell death and microglial activation.". Paper presented in Neuroscience 2012, New Orleans, 2012.
    Published
  24. Baptista, Sofia; Fontes-Ribeiro, Carlos A.; Agasse, Fabienne; Silva, Ana Paula. "Methamphetamine impairs dentate gyrus stem cell properties: Effect on cell cycle and self-renewal.". Paper presented in Neuroscience 2012, New Orleans, 2012.
    Published
  25. Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Agasse, Fabienne; Silva, Ana Paula. "Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in dentate gyrus cell cultures.". Paper presented in ISN/ESN 2011, 23rd Biennial Meeting, Athens, 2011.
    Published
  26. Gonçalves, Joana; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Silva, Ana Paula. "Neuropeptide Y is neuroprotective against methamphetamine-induced toxicity in hippocampal organotypic slice cultures". Paper presented in 8th IBRO World Congress of Neuroscience, Florence, 2011.
    Published • 10.1158/1538-7445.am2019-1096
  27. Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Agasse, Fabienne; Silva, Ana Paula. "Methamphetamine impairs neurogenesis in dentate gyrus cell cultures: protective role of neuropeptide Y.". Paper presented in 8th IBRO World Congress of Neuroscience, Florence, 2011.
    Published • 10.1109/ijcnn.2005.1555865
  28. Gonçalves, Joana; Baptista, Sofia; Santos, Paulo F.; Malva, João Oliveira; Silva, Ana Paula. "NPYergic system on microglial cells: Y2 receptor as a potential protector against METH-induced toxicity.". Paper presented in 7th Forum of European Neuroscience (FENS), Amsterdam, 2010.
    Published
  29. Martins, Tânia; Turowski, Patric; Milhazes, Nuno; Borges, Fernanda; Ambrósio, António Francisco; Silva, Ana Paula; Greenwood, John. "Methamphetamine induces the activation of endothelial nitric oxide synthase isoform in brain endothelial cells.". Paper presented in 7th Forum of European Neuroscience (FENS), Amsterdam, 2010.
    Published
  30. Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Agasse, Fabienne; Silva, Ana Paula. "Neuropeptide Y promotes proliferation, neuronal differentiation and protection against methamphetamine-induced toxicity in dentate gyrus cultures.". Paper presented in 7th Forum of European Neuroscience (FENS), Amsterdam, 2010.
    Published
  31. Pereira, Frederico P; Travassos, Ana Sofia; Gonçalves, Joana; Silva, Ana Paula; Ali, Syed F; Morgadinho, Teresa; Fontes-Ribeiro, Carlos. "Striatal glutamate­-glutamine cycling following a neurotoxic dose of methamphetamine.". Paper presented in 7th FENS - Forum of European Neuroscience, Amsterdam, 2010.
    Published
  32. Schitine CS; Agasse F; Xapelli S; Silva AP; Reis RAM; De Mello FG; Malva JO. "Ampakines as proneurogenic modulators in murine subventricular zone cell cultures". Paper presented in Neuroscience 2010 (SfN Meeting), San Diego, 2010.
    Published
  33. Gonçalves, Joana; Baptista, Sofia; Machado, S.P.; Milhazes, Nuno; Borges, Fernanda; Santos, Paulo F.; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Silva, Ana Paula. "Effect of methamphetamine on microglial cells and protective role of neuropeptide Y.". Paper presented in Neuroscience 2009, Chicago, 2009.
    Published
  34. Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Fontes- Ribeiro, Carlos A.; Malva, João Oliveira; Silva, Ana Paula. "Effect of methamphetamine on the mice hippocampus: neuroinflammation and neuronal dysfunction.". Paper presented in 2nd Biennial Meeting of Internacional Society for Neurochemistry, Busan, 2009.
    Published
  35. Martins, Tânia; Leal, Ermelindo C; Baptista, Sofia; Gonçalves, Joana; Milhazes, Nuno; Borges, Fernanda; Fontes- Ribeiro, Carlos A.; Ambrósio, António Francisco; Silva, Ana Paula. "Methamphetamine increases the blood-brain barrier permeability in the mice hippocampus: alterations in tight junction proteins.". Paper presented in 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Published
  36. Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Malva, João O.; Silva, Ana Paula. "Methamphetamine induces neuroinflammation and neuronal dysfunction in the mice hippocampus". Paper presented in 11th Meeting of the Portuguese Society of Neuroscience, Braga, 2009.
    Published
  37. Silva, Ana Paula; Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Trindade, L.; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira. "Methamphetamine triggers an inflammatory process in the mice hippocampus: relationship to gliosis and pro-inflammatory cytokines". Paper presented in Neuroscience 2008, Washington, 2008.
    Published
  38. Martins, Tânia; Gonçalves, Joana; Santiago, J.G.; Milhazes, Nuno; Borges, Fernanda; Fontes- Ribeiro, Carlos A.; Ambrósio, António Francisco; Macedo, Tice R.; Silva, Ana Paula. "Blood-brain barrier permeability and tight junction proteins are altered in the mice brain after an acute administration of methamphetamine.". Paper presented in 6th FENS Forum 2008, Geneva, 2008.
    Published
  39. Gonçalves, Joana; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Fontes- Ribeiro, Carlos A.; Malva, João Oliveira; Macedo, Tice R.; Silva, Ana Paula. "Methamphetamine hits different cell population in the hippocampus and rapidly triggers an inflammatory process.". Paper presented in 6th FENS Forum 2008, Geneva, 2008.
    Published
  40. Xapelli, Sara; Bernardino, Liliana; Ferreira, Raquel; Grade, Sofia; Silva, Ana Paula; Salgado, J.R.; Cavadas, Cláudia; et al. "Neuroprotective interactions between neuropeptide Y and brain-derived neurotrophic factor: a role for microglia.". Paper presented in 6th FENS Forum 2008, Geneva, 2008.
    Published
  41. Xapelli, Sara; Bernardino, Liliana; Ferreira, Raquel; Grade, Sofia; Silva, Ana Paula; Cavadas, Cláudia; Grouzmann, Eric; et al. "Interaction between neurons and microglia in NPY and BDNF-mediated neuroprotection against excitotoxicity.". Paper presented in Neuroscience 2007, San Diego, 2007.
    Published
  42. Fontes-Ribeiro, Carlos A.; Marques, Elsa; Silva, Ana Paula; Pereira, Frederico C.; Vasconcelos, Filipa; Morgadinho, Teresa; Macedo, Tice. "Amphetamine-induced release of dopamine in the striatum is decreased by training whereas neurodegeneration is not changed.". Paper presented in 2th Annual Congress of the European College of Sport Science Finland,, Jyvaskyla, 2007.
    Published
  43. Agasse, Fabienne; Bernardino, Liliana; Grade, Sofia; Silva, Ana Paula; Ferreira, Raquel; Silva, Bruno A.; Malva, João Oliveira. "Subventricular zone (SVZ) cells as a tool for neuronal replacement in mice models of temporal lobe epilepsy". Paper presented in Neuroscience 2006, Atlanta, 2006.
    Published
  44. Bernardino, Liliana; Agasse, Fabienne; Grade, Sofia; Silva, Ana Paula; Ferreira, Raquel; Silva, Bruno A.; Malva, João Oliveira. "Tumor necrosis factor-alpha induces differentiation of new neurons in neonatal subventricular zone cell cultures". Paper presented in Neuroscience 2006, Atlanta, 2006.
    Published
  45. Silva, Ana Paula; Lourenço, Joana; Xapelli, Sara; Ferreira, Raquel; Kristiansen, Heidi; Woldbye, David P. D.; Oliveira, Catarina R.; Malva, João Oliveira. "Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus". Paper presented in Neuroscience 2006, Atlanta, 2006.
    Published
  46. Xapelli, Sara; Bernardino, Liliana; Silva, Ana Paula; Cavadas, Cláudia; Grouzmann, Eric; Poulsen, F. R.; Jakobsen, B.; et al. "NPY triggers neuroprotection mechanisms following excitotoxic in mouse organotypic hippocampal slice cultures.". Paper presented in Neuroscience 2005, Washington, 2005.
    Published
  47. Silva, Ana Paula; Xapelli, Sara; Ferreira, Raquel; Pinheiro, Paulo S.; Bernardino, Liliana; Oliveira, Catarina R.; Zimmer, J.; Malva, João Oliveira. "Activation of neuropeptide Y1 or Y2 receptors can prevent the excitotoxicity induced by kainate in rat organotypic hippocampal slice cultures". Paper presented in Neuroscience 2005, Washington, 2005.
    Published
  48. Silva, Ana Paula; Lourenço, Joana C.; Oliveira, Catarina R.; Malva, João Oliveira. "Involvement of protein kinase C in the inhibition of glutamate release mediated by neuropeptide Y2 receptors in the hippocampus". Paper presented in International/European Society for Neurochemistry, Innsbruck, 2005.
    Published
  49. Álvaro, Ana Rita; Santiago, A.; Silva, Ana Paula; Malva, João Oliveira; Grouzmann, Eric; Carvalho, Ana Luísa; Ambrósio, António Francisco; Cavadas, Cláudia. "The role of neuropeptide Y (NPY) and NPY receptors on the [Ca2+]i changes in retinal neural cells". Paper presented in ARVO 2005 Annual Meeting (Invest. Ophthalmol. Vis. Sci. 2005 46), Fort Laudardale, Florida, 2005.
    Published
  50. Xapelli S; Bernardino L; Silva AP; Cavadas C; Grouzmann E; Poulsen FR; Jakobsen B; et al. "NPY triggers neuroprotection mechanisms following excitotoxic insults in mouse organotypic hippocampal slice cultures". Paper presented in Neuroscience 2005 (SfN Meeting), Washington, 2005.
    Published
  51. Vezzani A; Bernardino L; Xapelli S; Silva AP; Poulsen FR; Jakobsen B; Oliveira CR; Zimmer J; Malva JO. "Distinct tumor necrosis factor-alpha (TNF-a) receptor subtypes modulate neuronal survival to excitotoxic injury in mouse organotypic hippocampal slice cultures". Paper presented in Neuroscience 2005 (SfN Meeting), Washington, 2005.
    Published
  52. Silva, Ana Paula; Xapelli, Sara; Bernardino, Liliana; Poulsen, F. R.; Jakobsen, B.; Oliveira, Catarina R.; Malva, João Oliveira; Zimmer, J.. "Neuroprotection and decrease of Brain Derived Neurotrophic Factor expression mediated by neuropeptide Y2 receptor activation in mouse organotypic hippocampal cultures.". Paper presented in Neuroscience 2004, San Diego, 2004.
    Published
  53. Xapelli, Sara; Silva, Ana Paula; Pinheiro, Paulo S.; Cavadas, Cláudia; Jakobsen, B.; Zimmer, J.; Grouzmann, Eric; Oliveira, Catarina R.; Malva, João Oliveira. "Up-regulation of neuropeptide Y2 receptors and neuropetide Y levels following kainate injection in rats.". Paper presented in Forum of European Neuroscience (FENS) 2004, Lisbon, 2004.
    Published
  54. Lourenço, Joana; Oliveira, Catarina R.; Malva, João Oliveira; Silva, Ana Paula. "Modulation of [Ca2+]i changes by neuropeptide Y receptor activation: Single cell imaging of hippocampal neurons.". Paper presented in Forum of European Neuroscience (FENS) 2004, Lisbon, 2004.
    Published
  55. Silva AP; Xapelli S; Bernardino L; Poulsen FR; Jakobsen B; Oliveira CR; Malva JO; Zimmer J. "Neuroprotection and decreased of brain derived neurotrophic factor expression mediated by neuropeptide Y2 receptor activation in mouse organotypic hippocampal slice cultures". Paper presented in Neuroscience 2004 (SfN Meeting), San Diego, 2004.
    Published
  56. Malva JO; Bernardino L; Xapelli S; Silva AP; Jakobsen B; Poulsen FR; Oliveira CR; Zimmer J. "Activation of microglia in excitotoxic lesions in organotypic slice cultures of the mouse hippocampus". Paper presented in Neuroscience 2004 (SfN Meeting), San Diego, 2004.
    Published
  57. Silva, Ana Paula; Xapelli, Sara; Cavadas, Cláudia; Ffrench-Mullen, J. M.; Oliveira, Catarina R.; Malva, João Oliveira. "Modulation of glutamate release and expression of neuropeptide Y receptors in epileptic rats". Paper presented in Neuroscience 2003, New Orleans, 2003.
    Published • 10.1135/css200306125
  58. Silva, Ana Paula; Carvalho, Arsélio Pato; Carvalho, Caetana M.; Malva, João Oliveira. "Neuropeptide Y1/Y2 receptor interaction and inhibition of glutamate release in rat hippocampal synaptosomes.". Paper presented in Neuroscience 2001, San Diego, 2001.
    Published • 10.1109/embc.2019.8856638
  59. Rego, Ana Cristina; Monteiro, Nuno M.; Silva, Ana Paula; Malva, João Oliveira; Oliveira, Catarina R.. "Cell death upon activation of nondesensitizing AMPA receptors in cultured hippocampal neurons.". Paper presented in Neuroscience 2001, San Diego, 2001.
    Published
  60. Silva, Ana Paula; Carvalho, Arsélio Pato; Carvalho, Caetana M.; Malva, João Oliveira. "Modulation of calcium influx and glutamate release by neuropeptide Y1 and Y2 receptors in the hippocampus: differential effects in subregions.". Paper presented in Joint Meeting of International Society for Neurochemistry and the American Society for Neurochemistry (J. Neurochem), Buenos Aires, 2001.
    Published
  61. Monteiro, Nuno M.; Rego, Ana Cristina; Silva, Ana Paula; Malva, João Oliveira; Oliveira, Catarina R.. "Involvement of apoptosis and oxidative stress upon stimulation of non-dessensitizing AMPA receptors in cultured hippocampal neurons". Paper presented in 27th Meeting of the Federation of European Biochemical Societies (Eur. J. Biochem. 268, vol. 1, PS4-107), Lisbon, 2001.
    Published
  62. Silva, Ana Paula; Malva, João Oliveira; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Modulation of glutamate release and calcium influx by NPY Y1 and Y2 receptors in the rat hippocampus". Paper presented in Forum of European Neuroscience 2000 (Eur. J. Neurosci.), Brighton, 2000.
    Published
  63. Malva, João Oliveira; Ambrósio, António Francisco; Silva, Ana Paula; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Pharmacological dissection of AMPA and kainate receptors modulating intracellular free calcium concentration in cultured hippocampal neurons". Paper presented in Forum of European Neuroscience (FENS) 2000 (Eur. J. Neurosci., Suppl. 11, 213.16.), Brighton, 2000.
    Published
  64. Ambrósio, António Francisco; Silva, Ana Paula; Malva, João Oliveira; Carvalho, Arsélio Pato. "Role of blockade of AMPA receptor desensitization on neurotoxicity and intracellular calcium changes in rat hippocampal neurons.". Paper presented in Forum of European Neuroscience (FENS) 2000 (Eur. J. Neurosci., Suppl. 11, 213.04), Brighton, 2000.
    Published
  65. Silva, Ana Paula; Malva, João Oliveira; Ambrósio, António Francisco; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Ionotropic glutamate receptors-mediated toxicity in cultured rat hippocampal neurons". Paper presented in International Conference - Neuroprotection and Neurorepair – Cellular and Molecular Mechanisms Involved in Stroke, Ischemia and Trauma (Restor. Neurol. Neurosci.), Magdburg, 2000.
    Published
  66. Silva, Ana Paula; Malva, João Oliveira; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Presynaptic modulation of glutamate release by NPY Y2 receptors in the rat hippocampus.". Paper presented in Neuroscience 1999 (Soc Neurosci Abstr. 77.13, Vol. 25, Part 2, p.1867), Miami, 1999.
    Published
  67. Ambrósio, António Francisco; Silva, Ana Paula; Malva, João Oliveira; Soares-da-Silva, Patrício; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Effects of some antiepileptic drugs on the kainate- or veratridine-induced toxicity in cultured hippocampal neurons.". Paper presented in Neuroscience 1999, Miami, 1999.
    Published
  68. Ambrósio, António Francisco; Silva, Ana Paula; Malva, João Oliveira; Soares-da-Silva, Patrício; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Inhibition of L-Type Ca2+ channels by carbamazepine in cultured rat hippocampal neurons stimulated with ionotropic glutamate receptor agonists.". Paper presented in Joint Meeting of British Pharmacological Society and Sociedade Portuguesa de Farmacologia (B. J. Pharmacol. 127: 46P)., Porto, 1999.
    Published
  69. Ambrósio, António Francisco; Silva, Ana Paula; Malva, João Oliveira; Carvalho, Caetana M.; Soares-da-Silva, Patrício; Carvalho, Arsélio Pato. "Effects of carbamazepine on [Ca2+]i and [Na+]i signals stimulated by ionotropic glutamate receptors agonists.". Paper presented in Forum of European Neuroscience (FENS) 1998 (Eur. J. Neurosci., Suppl. 10 , p. 54.48), Berlin, 1998.
    Published
Conference paper
  1. Bento, A.R.; Baptista, S.; Malva, J.O.; Silva, A.P.; Agasse, F.. "The effect of methamphetamine on subventricular zone neurogenesis: Cell death, proliferation and differentiation". 2012.
    10.1109/ENBENG.2012.6331378
Conference poster
  1. Silva, Ana Paula; Daniela Simões; Alexandre Henriques; Eliane Sanches; Filipa Baptista. "Impact of acute stress on behavior and neuroinflammation: a pre-clinical study". Paper presented in IBRO 2023 - IBRO World Congress of Neuroscience, 2023.
  2. Filipa Baptisa; Daniela Simões; Alexandre Henriques; Eliane Sanches; Silva, Ana Paula. "IMPACT OF CHRONIC STRESS IN BLOOD-BRAIN BARRIER: FOCUS ON C3 COMPLEMENT PATHWAY AND SEX DIFFERENCES". Paper presented in IBRO 2023 - IBRO World Congress of Neuroscience, 2023.
  3. Daniela Simões; Alexandre Henriques; Eliane Sanches; Filipa Baptista; Silva, Ana Paula. "ACUTE STRESS INDUCES RAT BEHAVIOURAL ALTERATIONS AND A NEUROINFLAMMATORY RESPONSE". Paper presented in FENS Regional Meeting 2023, 2023.
  4. Sanches, Eliane Swely. "Retinal physiology and function in control and ADHD conditions with(out) methylphenidate treatment". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  5. Leitão, Ricardo Alexandre; Alves JL; Bernardo AL; Fontes-Ribeiro CA; Silva AP. "Microglial and astrocytic responses after traumatic brain injury: role of neuropeptide Y". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  6. Leitão, Ricardo Alexandre. "Impact of traumatic brain injury on blood-brain barrier properties: role of neuropeptide Y". Paper presented in Signal Transduction at the Blood-Brain Barriers, 2021.
  7. Santos, Liliana; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "The VGF-derived peptide TLQP-21 released by breast cancer cells promotes the loss of brain endothelial cell monolayer integrity". Paper presented in CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH webinar organized by Liga Portuguesa Contra o Cancro, 2020.
  8. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "VGF-secreted peptide derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in EACR-AACR Basic and Translational Research Conference in partnership with ASPIC Tumor Microenvironment; Lisbon, Portugal, 2020.
  9. Martins, Beatriz; Novo, João P.; Silva, Ana Paula; Pereira, Frederico C.; Oriá, Reinaldo; Fontes-Ribeiro, Carlos A.; Malva, João O.. "Unravelling the effect of methylmercury exposure in neuroinflammation". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  10. Bernardo, Ana Luísa; Leitão, Ricardo Alexandre; Alves, José Luís; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of neuropeptide Y in astrocytic alterations induced by traumatic brain injury: in vitro study". Paper presented in IV Portuguese Glial Networking, Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
  11. Bernardo, Ana Luisa; Leitão, Ricardo Alexandre; Alves, José Luis; Fontes-Ribeiro, Carlos A; Silva, Ana Paula. "Effect of traumatic brain injury in vitro model on astrocytes function: role of neuropeptide Y". Paper presented in IV Symposium PT Glial Network, 2019.
  12. Silva, Ana Paula; Madeira, Maria H.; Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Boia, Raquel; Fontes-Ribeiro, Carlos A.; Fernandes, Rosa. "An eye on ADHD: Can the retina be used as a diagnostic support tool?". Paper presented in 7th World Congress on ADHD, 2019.
  13. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Silva, Ana Paula; Gomes, Célia; Paredes, Joana; Ribeiro, Ana Sofia. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis". Paper presented in 2nd Joint EACR-MRS Conference. Seed and Soil-In vivo Models of metastasis, 2019.
  14. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "Secretome derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in CIBB Meeting, 2019.
  15. Coelho-Santos, Vanessa; Cradoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Early developmental long-lasting exposure to methylphenidate: New insights into attention-deficit/hyperactivity disorder". Paper presented in ISDN 2018: 22nd Biennial Meeting of the International Society for Developmental Neuroscience, 2018.
  16. Ventura, Fabiana; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Behavioural alterations and blood-brain barrier dysfunction triggered by methamphetamine: What is the role of neuropeptide Y?". Paper presented in 9th Annual International Medical Students (AIMS) Meeting, 2018.
  17. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo Alexandre; Gomes, Célia; Rito, Manuel; et al. "Neurogliovascular alterations triggered by early developmental chronic consumption of methylphenidate". Paper presented in Neural Development – EMBO Workshop, 2018.
  18. Couto, Marina; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula; Gomes, Célia. "Microglia promote endotelial Cell dysfunction in glioblastoma". Paper presented in CIMAGO Scientific Meeting 2018, 2018.
  19. Silva, Ana Paula; Coelho-Santos, Vanessa; Cardoso, Filipa; Leitão, Ricardo Alexandre; Magalhães, Ana; Ferreira-Teixeira, Margarida; Gomes, Célia; et al. "Unravelling the impact of methylphenidate on neurogliovascular function: implications for memory performance". Paper presented in XIII European Meeting on Glial Cells in Health and Disease, GLIA 2017, Edinburgh, UK, 2017.
  20. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Brain immune response triggered by early developmental chronic consumption of methylphenidate: control vs attention-deficit/hyperactivity disorder rat model". Paper presented in XXVI AINI Congress and 16th ESNI Course, 2017.
  21. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Effects of early developmental chronic exposure to methylphenidate on both brain´s immune privilege and anxiety-like behavior: Control vs ADHD rats.". Paper presented in XV Portuguese Society for Neurosciences (Braga, Portugal), 2017.
  22. Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Magalhães, Ana; Ferreira-Teixeira, Margarida; Gomes, Célia; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Neurogliovascular alterations induced by chronic treatment of methylphenidate: repercussions on memory function". Paper presented in Reactive gliosis - from mechanobiology and signal transduction to molecular targets and disease pathogenesis (Aspenäs, Gothenburg, Sweden), 2017.
  23. Coelho-Santos, Vanessa; Cardoso, Filipa L; Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Impact of methylphenidate chronic treatment in brain immune surveillance and neuroinflammation: control vs hyperactive rats". Paper presented in Society for Neuroscience, 2016.
  24. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Effects of chronic exposure to methylphenidate on behavior and blood-brain barrier function: control vs hyperactive rats". Paper presented in VII Annual Meeting of IBILI (Coimbra, Portugal), 2015.
  25. Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo Alexandre; Cai, Yin; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. "Regional difference in susceptibility to modulation of excitation/inhibition balance and glial function in mouse model of neurofibromatosis type 1.". Paper presented in IBILI Meeting 2015, 2015.
  26. Leitão, Ricardo Alexandre; Gonçalves, Joana; Assis, María Amparo; Coria, Santiago M.; Ambrosio, Emilio; Silva, Ana Paula. "Blood-brain barrier dysfunction and neuroinflammation triggered by chronic methamphetamine self-admnistration in rats.". Paper presented in IBILI Meeting 2015, 2015.
  27. Méndez-Couz, Marta; Silva, Ana Paula; Gonçalves, Joana; González-Pardo, H.; Arias, J. L.; Conejo, N. M.. "Temporal inactivation of neuropeptide y2 receptor improves spatial memory and modifies brain metabolism in limbic regions.". Paper presented in I International Congress of Psychobiology, 2015.
  28. Leitão, Ricardo Alexandre; Coelho-Santos, V.; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methamphetamine-induced blood-brain barrier disruption and brain edema: The role of water channel aquaporin-4". Paper presented in XIV Meeting of Portuguese Society of Neuroscience (Póvoa do Varzim, Portugal), 2015.
  29. Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Leitão, Ricardo Alexandre; Rito, Manuel; Barbosa, Marcos; Cardoso, Filipa L.; et al. "Methylphenidate activates Src pathway leading to caveolae-mediated transcytosis in human brain endothelial cells". Paper presented in XIV Portuguese Society for Neurosciences (Póvoa do Varzim, Portugal), 2015.
  30. Coelho-Santos, Vanessa; Socodato, Renato; Portugal, Camila; Leitão, Ricardo Alexandre; Rito, Manuel; Barbosa, Marcos; Couraud, Pierre-Olivier; et al. "Unmasking the underlying mechanisms of methylphenidate effects on human brain endothelial cells.". Paper presented in In4Med, Medical and Scientific Meeting (Coimbra, Portugal), 2015.
  31. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of aquaporin 4 in methamphetamine-induced blood-brain barrier dysfunction and brain edema.". Paper presented in In4Med, Medical and Scientific Meeting (Coimbra, Portugal), 2015.
  32. Coelho-Santos, Vanessa; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methylphenidate promotes caveolae-dependent vesicular transport in human brain endothelial cells: role of reactive oxygen species and Src pathway.". Paper presented in XVIII Meeting of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  33. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of aquaporin-4 in brain edema and blood-brain barrier breakdown induced by methamphetamine.". Paper presented in XVIII Meeting of the Portuguese Biochemical Society (Coimbra, Portugal), 2014.
  34. Coelho-Santos, Vanessa; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methylphenidate increases caveolar endocytosis in human brain endothelial cell: role of oxidative stress.". Paper presented in VI Annual Meeting of IBILI (Coimbra, Portugal), 2014.
  35. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methamphetamine-induced blood-brain barrier dysfunction: role of Aquaporin 4.". Paper presented in VI Annual Meeting of IBILI (Coimbra, Portugal), 2014.
  36. Coelho-Santos, Vanessa; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methylphenidate promotes caveolae-dependent transcytosis in human brain endothelial cell.". Paper presented in 17th International Symposium Signal Transduction at the Blood-Brain and Blood-Retina Barriers (Dublin, Ireland), 2014.
  37. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Methamphetamine-induced blood-brain barrier dysfunction: role of aquaporin 4.". Paper presented in 17th International Symposium Signal Transduction at the Blood-Brain and Blood-Retina Barriers (Dublin, Ireland), 2014.
  38. Coelho-Santos, Vanessa; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of oxidative stress in methylphenidate-mediated brain endothelial cell vesicular transport.". Paper presented in International Psychiatric Conference, Neurobiology and Complex Treatment of Psychiatric Disorders and Addiction (Varsaw, Poland), 2014.
  39. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos A.; Silva, Ana Paula. "Role of aquaporin-4 in methamphetamine-induced brain edema and blood-brain barrier dysfunction.". Paper presented in Astrocytes in Health and Neurodegenerative Disease. A joint Biochemical Society / British Neuroscience Association Focused Meeting (London, UK), 2014.
  40. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Role of brain edema in methamphetamine-induced blood-brain barrier dysfunction.". Paper presented in Astrocytes in Health and Neurodegenerative Disease., 2014.
  41. Gonçalves, Joana; Baptista, Sofia; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana Paula. "Alterações do sistema do neuropeptídeo Y no hipocampo induzidas por metanfetamina: consequências cognitivas.". Paper presented in Congresso Nacional de Adictologia, 2013.
  42. Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa L.; Fontes-Ribeiro, Carlos A.; Brito, Maria Alexandra; Silva, Ana Paula. "The role of TNF-alpha in METH-induced barrier dysfunction.". Paper presented in XIII Portuguese Society for Neuroscience (Luso, Portugal), 2013.
  43. Silva, Ana Paula; Coelho-Santos, Vanessa. "Impact of methamphetamine on the crosstalk between brain endothelial cells and astrocytes: implications for barrier function.". Paper presented in Symposium Beating the Blood-Brain and Other Blood Barriers (Lisbon, Portugal), 2013.
  44. Leitão, Ricardo Alexandre; Coelho-Santos, Vanessa; Cardoso, Filipa Lourenço; Fontes-Ribeiro, Carlos; Brito, Maria A; Silva, Ana Paula. "Disfunção da barreira hematoencefálica induzida por metanfetamina (Methamphetamine-induced blood-brain barrier dysfunction)". Paper presented in Congresso Nacional de Adictologia - Saúde, Neurociências e Adições, 2013.
  45. Leitão, Ricardo Alexandre; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Methamphetamine induces alterations in brain aquaporin 4 expression.". Paper presented in 4th PF2MUC Symposium - Personalized Medicine: myth or reality?, 2013.
  46. Coelho-Santos, Vanessa; Leitão, Ricardo Alexandre; Cardoso, Filipa L; Fontes-Ribeiro, Carlos; Brito, Maria A; Silva, Ana Paula. "The role of TNF-a in METH-induced barrier dysfunction". Paper presented in 13th Meeting of the Portuguese Society for Neurosciences, 2013.
  47. Coelho-Santos, Vanessa; Rito, Manuel; Barbosa, Marcos; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Methylphenidate increases human endothelial cell permeability". Paper presented in V Annual Meeting of IBILI, 2013.
  48. Fontes-Ribeiro, Carlos; Pinheiro, Vitor; Baptista, Sofia; Gonçalves, Joana; Leitão, Ricardo Alexandre; Silva, Ana Paula. "Acute physical exercise and blood­-brain barrier permeability.". Paper presented in 17th Annual ECSS Congress, 2012.
  49. Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Methamphetamine-induced permeability in brain endothelial cells". Paper presented in IV Annual Meeting of IBILI, 2012.
  50. Gonçalves, Joana; Fontes-Ribeiro, Carlos; Malva, João O.; Silva, Ana Paula. "Neuropeptide Y affords protection against methamphetamine-­-induced neuronal and microglial toxicity.". Paper presented in 3rd Annual Meeting IBILI, 2011.
  51. Gonçalves, Joana; Baptista, Sofia; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana Paula. "Involvement of NPY system in memory impairment induced by methamphetamine.". Paper presented in 3rd International Drug Abuse Research Society/ISN/ESN Satellite Meeting, 2011.
  52. Gonçalves, Joana; Baptista, Sofia; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana Paula. "Neuropeptide Y system changes and memory impairment induced by methamphetamine: role of Y2 receptors.". Paper presented in 12th Meeting of the Portuguese Society of Neuroscience, 2011.
  53. Coelho-Santos, Vanessa; Gonçalves, Joana; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Methamphetamine induces microglial cell death: Protective effect of tumor necrosis factor-alpha and interleukin-6". Paper presented in III Annual Meeting of IBILI, 2011.
  54. Gonçalves, Joana; Pinto, Juliana; Alves, Nuno Dinis; Martins, A.; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana Paula. "Hippocampal Neuropeptide Y System and its Protective Role against Methamphetamine­-induced neurotoxicity.". Paper presented in 2nd Annual Meeting IBILI, 2010.
  55. Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Fontes-Ribeiro, Carlos; Malva, João O.; Agasse, Fabienne; Silva, Ana Paula. "Neuropeptide Y promotes neurogenesis and protection against methamphetamine­-induced toxicity in dentate gyrus cultures.". Paper presented in 2nd Meeting IBLI, 2010.
  56. Martins, Tânia; Leal, Ermelindo C; Baptista, Sofia; Gonçalves, Joana; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Ambrósio, António Francisco; Silva, Ana Paula. "Methamphetamine increases the blood-brain barrier permeability and decreases tight junction protein levels in the mice hippocampus.". Paper presented in 12th International Symposium for Signaling at the Blood-­-Brain and Retinal Barriers, 2009.
  57. Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Malva, João O.; Silva, Ana Paula. "Indomethancin prevents methamphetamine­-induced neuroinflammation in the mice hippocampus.". Paper presented in 9th ISN Advanced School of Neurochemistry ­- Cellular communication in the nervous system, 2009.
  58. Pereira, Frederico C; Travassos, Ana Sofia; Gonçalves, Joana; Silva, Ana Paula; Morgadinho, Teresa; Ali, Syed F; Fontes-Ribeiro, Carlos. "A single dose of methamphetamine evokes astrocyte­-related glutamatergic changes.". Paper presented in 2nd Annual International Drug Abuse Research Society Meeting ­- ISN/ASN, 2009.
  59. Schitine CS; Agasse F; Xapelli S; Silva AP; De Melo Reis RA; De Mello FG; Malva JO. "AMPA and ampakines as proneurogenic modulators of progenitors derived from subventricular zone". Paper presented in FeSBE 2009, XXIV Annual Meeting, São Paulo, Brasil, 2009.
  60. Silva, Ana Paula; Gonçalves, Joana; Baptista, Sofia; Santos, Paulo F.; Fontes-Ribeiro, Carlos A.; Malva, João Oliveira; Macedo, Tice R.. "Methamphetamine-induced microglial cell death: an in vitro study to evaluated the possible protective role of neuropeptide Y.". Paper presented in Internacional Symposium on Drugs of Abuse, Island of São Miguel, Azores, Portugal, 2008.
  61. Silva, Ana Paula; Martins, Tânia; Gonçalves, Joana; Ferreira, Raquel; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos A.; Macedo, Tice R.. "Dynamic of glial cells in the mouse hippocampus following acute administration of methamphetamine.". Paper presented in 1st Annual International Drug Abuse Research Society (IDARS) & International Society for Neurochemistry Satellite Meeting", Mérida, Mexico, 2007.
  62. Xapelli S; Bernardino L; Ferreira R.; Grade S; Silva AP; Cavadas C; Grouzmann E; et al. "Interactions between NPY and BDNF in neuroprotection against excitotoxicity: a role for neuron-microglia crosstalk?". Paper presented in 10th Meeting of the Portuguese Society for Neuroscience (SPN), Ofir, Portugal, 2007.
  63. Silva, Ana Paula; Simões, Ana Patrícia; Pereira, Frederico C.; Grade, Sofia; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos A.; Macedo, Tice R.. "Methamphetamine-induced alteration of ionotropic glutamate receptor expression in the hippocampus and short-term memory deficit". Paper presented in Neurobiology and Drug Abuse Meeting, Porto, Portugal,, 2006.
  64. Silva, Ana Paula; Lourenco, Joana; Xapelli, Sara; Ferreira, Raquel; Oliveira, Catarina R.; Kristiansen, Heidi; Woldbye, David P. D.; Malva, João Oliveira. "Cross-talk between neuropeptide Y and PKC in the modulation of glutamate release in the hippocampus of kainate-induced epileptic rats.". Paper presented in 8th NPY Meeting, St. Petersburg, Florida, USA, 2006.
  65. Xapelli S; Bernardino L; Silva AP; Salgado JR; Cavadas C; Grouzmann E; Poulsen FR; et al. "Implication of BDNF in the neuroprotective effect of NPY in mouse hippocampal slice cultures exposed to excitotoxic insults". Paper presented in 8th International NPY meeting, St. Petersburg, Estados Unidos, 2006.
  66. Silva, Ana Paula; Lourenço, Joana; Xapelli, Sara; Oliveira, Catarina R.; Malva, João Oliveira. "Protein kinase C signalling is involved in the modulation of glutamate release mediated by neuropeptide Y2 receptors in the hippocampus of epileptic rats". Paper presented in 9ª Meeting the Portuguese Society for Neuroscience (SPN), 2005.
  67. Xapelli S; Silva AP; Ferreira R.; Bernardino L; Pinheiro P; Zimmer J; Oliveira CR; Malva JO. "NPY Y1 and Y2 receptors activation can rescue neurons following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures". Paper presented in Neuro-glia Interaction in Aging and Disease (FENS/Blackwell Summer School), Ofir, Portugal, 2005.
  68. Lourenço J; Xapelli S; Oliveira CR; Malva JO; Silva AP. "Involvement of Protein Kinase C in the modulation of glutamate release mediated by neuropeptide Y2 receptors in the hippocampus of epileptic rats". Paper presented in Neuro-glia Interaction in Aging and Disease (FENS/Blackwell Summer School), Ofir, Portugal, 2005.
  69. Silva, Ana Paula; Xapelli, Sara; Oliveira, Catarina R.; Malva, João Oliveira. "Functional interaction between neuropeptide Y receptors and modulation of glutamate release in control and epileptic rat hippocampus". Paper presented in 1st Neuroscience Symposium”, Natal, Brazil, 2004.
  70. Malva JO; Silva AP; Xapelli S; Pinheiro PS; Cavadas C; Oliveira CR. "Modulation of presynaptic excitability by kainate and NPY receptors in the rat hippocampus: relevance for epileptogenesis and neuroprotection". Paper presented in 1st Neuroscience Symposium, Natal, Brasil, 2004.
  71. Xapelli S; Bernardino L; Silva AP; Poulsen FR; Jakobsen B; Oliveira CR; Malva JO; Zimmer J. "Involvement of neuropeptide Y2 receptor in neuroprotection and decrease of Brain Derived Neurotrophic Factor expression under excitotoxicity in mouse organotypic hippocampal slice cultures". Paper presented in XIV Meeting of Portuguese Biochemical Society, Vilamoura, Portugal, 2004.
  72. Xapelli S; Silva AP; Bernardino L; Jakobsen B; Zimmer J; Oliveira CR; Malva JO. "Neuroprotection by neuropeptide Y activation in excitotoxicity and epilepsy". Paper presented in Brain Damage Repair, Lisboa, Portugal, 2004.
  73. Xapelli S; Bernardino L; Silva AP; Jakobsen B; Zimmer J; Malva JO. "Activation of neuropeptide Y2 and Y5 receptor is neuroprotective against excitotoxicity induced by AMPA in mouse organotypic hippocampal slice cultures". Paper presented in 7th International NPY meeting, Coimbra, Portugal, 2004.
  74. Silva, Ana Paula; Xapelli, Sara; Cavadas, Cláudia; Ffrench-Mullen, J. M.; Oliveira, Catarina R.; Malva, João O.. "Modulation of glutamate release by neuropeptide Y receptors activation in hippocampal nerve terminals of control and epileptic rats". Paper presented in 8ª Meeting of The Portuguese Society for Neuroscience (SPN), Curia, Portugal, 2003.
  75. Xapelli S; Silva AP; Pinheiro PS; Cavadas C; Oliveira CR; Malva JO. "Sub-cellular synaptic distribution of NPY Y2 and Y5 receptor subtypes and NPY levels in rat hippocampal subregions". Paper presented in 8th Annual meeting of The Portuguese Society for Neuroscience, Curia, Portugal, 2003.
  76. Silva, Ana Paula; Pinheiro, Paulo S.; Carvalho, Arsélio Pato; Carvalho, Caetana M.; Jakobsen, B.; Zimmer, J.; Malva, João O.. "Activation of neuropeptide Y receptors prevents AMPA and kainate cell death in the rat hippocampus". Paper presented in III Congresso de Investigação em Medicina, Coimbra, Portugal, 2002.
  77. Silva, Ana Paula; Carvalho, Arsélio Pato; Carvalho, Caetana M; Jakobsen, B.; Zimmer, J.; Malva, João O.. "Effect of neuropeptide Y receptors activation on the excitotoxicity induced by AMPA or kainate in organotypic hippocampal slice cultures.". Paper presented in Neurochemistry Winter Conference: How closely do genetic, neurochemical, electrophysiological and behavioral experimental models predict human patterns of abuse and dependence”, Sölden, Austria, 2002.
  78. Silva, Ana Paula; Malva, João O.; Ambrósio, António Francisco; Salgado, António J.; Carvalho, Arsélio Pato. "Role of kainate receptor activation and desensitization on the [Ca2+]i changes and neurotoxicity in cultured rat hippocampal neurons.". Paper presented in FEBS Course: From differentiation to death of nerve cells", Spetses Island, Greece, 2001.
  79. Silva, Ana Paula; Carvalho, Arsélio Pato; Carvalho, Caetana M.; Malva, João O.. "Modulation of glutamate release and calcium influx by NPY Y1 and Y2 receptors in the whole rat hippocampus and in CA1, CA3 and dentate gyrus". Paper presented in II Congresso de Investigação em Medicina, Coimbra, Portugal, 2000.
  80. Silva, Ana Paula; Malva, João O.; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Modulation of calcium influx and glutamate release by NPY Y2 receptors in the rat hippocampus and subregions". Paper presented in NATO/FEBS Advanced Study Institute on Protein modules in cellular signalling, 2000.
  81. Silva, Ana Paula; Ambrósio, António Francisco; Malva, João O.; Carvalho, Arsélio Pato; Carvalho, Caetana M.. "Excitotoxicity induced by AMPA and kainate receptors in cultured rat hippocampal neurons". Paper presented in 6ª Reunião da Sociedade Portuguesa de Neurociências”, Lisbon, Portugal, 1999.
  82. Silva, Ana Paula; Ambrósio, António Francisco; Malva, João O.; Carvalho, Caetana M.; Carvalho, Arsélio Pato. "Toxicity induced by AMPA receptors in cultured rat hippocampal neurons". Paper presented in XI Congresso Nacional de Bioquímica”, Tomar, Portugal, 1998.
Journal article
  1. Eliane Swely Sanches; Daniela Simões; Filipa Isabel Baptista; Ana Paula Silva. "Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches". European Journal of Clinical Investigation (2025): https://doi.org/10.1111/eci.14319.
    Published • 10.1111/eci.14319
  2. Rita Carvalho; Liliana Santos; Inês Conde; Ricardo Leitão; Hugo R.S. Ferreira; Célia Gomes; Silva, Ana Paula; et al. "Deciphering the impact of cancer cell´s secretome and its derived-peptide VGF on breast cancer brain metastasis (2024)". (2024): https://www.biorxiv.org/content/biorxiv/early/2024/02/25/2024.02.22.581537.full.pdf.
    Under revision
  3. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R S; Almeida, Sara F F; Ciputra, Edward; Sereno, José; Almeida, Rui; et al. "ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer". Neuro-Oncology (2024): https://doi.org/10.1093/neuonc/noae169.
    10.1093/neuonc/noae169
  4. Novo, João P.; Muga, Mariana; Lourenço, Teresa; Sanches, Eliane S.; Leitão, Ricardo A.; Silva, Ana Paula. "Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies". Toxicology Letters 389 (2023): 1-10. http://dx.doi.org/10.1016/j.toxlet.2023.10.008.
    Published • 10.1016/j.toxlet.2023.10.008
  5. Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, Rosa; Silva, Ana Paula. "Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterations and Methylphenidate Has a Differential Effect in ADHD versus Control Conditions". Antioxidants 12 4 (2023): 937. http://dx.doi.org/10.3390/antiox12040937.
    Published • 10.3390/antiox12040937
  6. Reinaldo B. Oriá; Raul S. Freitas; Cássia R. Roque; José Carlos R. Nascimento; Ana Paula P. S. Martins; João O. Malva; Richard L. Guerrant; Michael P. Vitek. "ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041086.
    10.3390/pharmaceutics15041086
  7. Ricardo A. Leitão; Carlos A. Fontes-Ribeiro; Ana Paula Silva. "The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13694.
    10.1111/eci.13694
  8. Méndez-Couz, Marta; Manahan-Vaughan, Denise; Silva, Ana Paula; González-Pardo, Héctor; Arias, Jorge Luis; Conejo, Nélida María. "Metaplastic contribution of neuropeptide Y receptors to spatial memory acquisition". Behavioural Brain Research 396 (2021): 112864. http://dx.doi.org/10.1016/j.bbr.2020.112864.
    Published • 10.1016/j.bbr.2020.112864
  9. Ventura, Fabiana; Muga, Mariana; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos A.; Leitão, Ricardo A.; Silva, Ana Paula. "Protective effect of neuropeptide Y2 receptor activation against methamphetamine-induced brain endothelial cell alterations". Toxicology Letters 334 (2020): 53-59. http://dx.doi.org/10.1016/j.toxlet.2020.09.013.
    Published • 10.1016/j.toxlet.2020.09.013
  10. Alves, José Luís; Mendes, João; Leitão, Ricardo; Silva, Ana Paula; Pinto, Anabela Mota. "A multi-staged neuropeptide response to traumatic brain injury". European Journal of Trauma and Emergency Surgery (2020): http://dx.doi.org/10.1007/s00068-020-01431-z.
    Published • 10.1007/s00068-020-01431-z
  11. Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; et al. "Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration". Cell Reports 31 12 (2020): 107796. http://dx.doi.org/10.1016/j.celrep.2020.107796.
    Published • 10.1016/j.celrep.2020.107796
  12. Couto, Marina; Coelho-Santos, Vanessa; Santos, Liliana; Fontes-Ribeiro, Carlos; Silva, Ana Paula; Gomes, Célia M. F.. "The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway". Journal of Cellular Physiology 234 11 (2019): 19750-19760. http://dx.doi.org/10.1002/jcp.28575.
    Published • 10.1002/jcp.28575
  13. de Aquino, Cristhyane Costa; Leitão, Ricardo A.; Oliveira Alves, Luís A.; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P.; Oriá, Reinaldo B.. "Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress". Frontiers in Nutrition 5 (2019): http://dx.doi.org/10.3389/fnut.2018.00131.
    Published • 10.3389/fnut.2018.00131
  14. Coelho-Santos, Vanessa; Cardoso, Filipa L.; Magalhães, Ana; Ferreira-Teixeira, Margarida; Leitão, Ricardo A.; Gomes, Célia; Rito, Manuel; et al. "Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats". European Neuropsychopharmacology 29 2 (2018): 195-210. http://dx.doi.org/10.1016/j.euroneuro.2018.12.007.
    Published • 10.1016/j.euroneuro.2018.12.007
  15. Gonçalves, Andreia; Almeida, Luísa; Silva, Ana Paula; Fontes-Ribeiro, Carlos; Ambrósio, António F.; Cristóvão, Armando; Fernandes, Rosa. "The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation". Biomedicine & Pharmacotherapy 102 (2018): 833-838. http://dx.doi.org/10.1016/j.biopha.2018.03.144.
    Accepted • 10.1016/j.biopha.2018.03.144
  16. Silva, Ana Paula. "Impact of developmental exposure to methylphenidate on rat brain's immune privilege and behavior: Control versus ADHD model.". Brain, behavior, and immunity (2017): http://europepmc.org/abstract/med/29061363.
    10.1016/j.bbi.2017.10.016
  17. Gonçalves, Joana; Violante, Inês R.; Sereno, José; Leitão, Ricardo A.; Cai, Ying; Abrunhosa, Antero; Silva, Ana Paula; Silva, Alcino J.; Castelo-Branco, Miguel. "Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes". Molecular Autism 8 1 (2017): http://dx.doi.org/10.1186/s13229-017-0166-4.
    Published • 10.1186/s13229-017-0166-4
  18. Valero, Jorge; Bernardino, Liliana; Cardoso, Filipa Lourenço; Silva, Ana Paula; Fontes-Ribeiro, Carlos; Ambrósio, António Francisco; Malva, João Oliveira. "Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer´s Disease". Journal of Alzheimer's Disease 60 s1 (2017): S161-S168. http://dx.doi.org/10.3233/jad-170239.
    Published • 10.3233/jad-170239
  19. Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
    10.1093/cvr/cvx118
  20. Leitão, Ricardo Alexandre; Sereno, José; Castelhano, João Miguel; Gonçalves, Sónia Isabel; Coelho-Santos, Vanessa; Fontes-Ribeiro, Carlos; Castelo-Branco, Miguel; Silva, Ana Paula. "Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior". Molecular Neurobiology 55 3 (2017): 2056-2069. http://dx.doi.org/10.1007/s12035-017-0439-0.
    Published • 10.1007/s12035-017-0439-0
  21. Gonçalves J; Leitão RA; Higuera-Matas A; Assis MA; Coria SM; Fontes-Ribeiro C; Ambrosio E; Silva AP. "Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown.". (2017): http://europepmc.org/abstract/med/28237710.
    10.1016/j.bbi.2017.02.017
  22. Coelho-Santos V; Socodato R; Portugal C; Leitão RA; Rito M; Barbosa M; Couraud PO; et al. "Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.". (2016): http://europepmc.org/abstract/med/27376435.
  23. Baptista, Sofia; Lourenço, Joana; Milhazes, Nuno; Borges, Fernanda; Silva, Ana Paula; Bacci, Alberto. "Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons". eneuro 3 3 (2016): ENEURO.0141-16.2016. http://dx.doi.org/10.1523/eneuro.0141-16.2016.
    Published • 10.1523/eneuro.0141-16.2016
  24. Leitão, Ricardo Alexandre; Silva, Ana Paula. "Psychostimulants and brain edema". Research & Networks in Health 1 1 (2015): https://journals.ipleiria.pt/index.php/rnhealth/article/view/60.
    Published
  25. Coelho-Santos, Vanessa; Leitão, Ricardo A; Cardoso, Filipa L; Palmela, Inês; Rito, Manuel; Barbosa, Marcos; Brito, Maria A; Fontes-Ribeiro, Carlos A; Silva, Ana P. "The TNF-alpha/NF-kB Signaling Pathway has a Key Role in Methamphetamine-Induced Blood-Brain Barrier Dysfunction". Journal of Cerebral Blood Flow & Metabolism 35 8 (2015): 1260-1271. http://dx.doi.org/10.1038/jcbfm.2015.59.
    Published • 10.1038/jcbfm.2015.59
  26. Gonçalves, Joana; Martins, João; Baptista, Sofia; Ambrósio, António Francisco; Silva, Ana Paula. "Effects of drugs of abuse on the central neuropeptide Y system". Addiction Biology 21 4 (2015): 755-765. http://dx.doi.org/10.1111/adb.12250.
    Published • 10.1111/adb.12250
  27. Gonçalves J; Martins J; Baptista S; Ambrósio AF; Silva AP. "Effects of drugs of abuse on the central neuropeptide Y system.". (2015): http://europepmc.org/abstract/med/25904345.
  28. Fernandes, S.; Salta, S.; Bravo, J.; Silva, A. P.; Summavielle, T.. "Acetyl-L-Carnitine Prevents Methamphetamine-Induced Structural Damage on Endothelial Cells via ILK-Related MMP-9 Activity". Molecular Neurobiology 53 1 (2014): 408-422. http://dx.doi.org/10.1007/s12035-014-8973-5.
    10.1007/s12035-014-8973-5
  29. Gonçalves, Joana; Baptista, Sofia; Silva, Ana Paula. "Psychostimulants and brain dysfunction: A review of the relevant neurotoxic effects". Neuropharmacology 87 (2014): 135-149. http://dx.doi.org/10.1016/j.neuropharm.2014.01.006.
    Published • 10.1016/j.neuropharm.2014.01.006
  30. Baptista, Sofia; Lasgi, Charlène; Benstaali, Caroline; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Agasse, Fabienne; Silva, Ana Paula. "Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate". Stem Cell Research 13 2 (2014): 329-341. http://dx.doi.org/10.1016/j.scr.2014.08.003.
    10.1016/j.scr.2014.08.003
  31. Capelôa T; Caramelo F; Fontes-Ribeiro C; Gomes C; Silva AP. "Erratum to: Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate.". (2014): http://europepmc.org/abstract/med/24788666.
    10.1007/s12640-014-9471-2
  32. Capelôa, Tânia; Caramelo, Francisco; Fontes-Ribeiro, Carlos; Gomes, Célia; Silva, Ana P.. "Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate". Neurotoxicity Research 26 3 (2014): 216-227. http://dx.doi.org/10.1007/s12640-014-9464-1.
    Published • 10.1007/s12640-014-9464-1
  33. Martins, Tânia; Burgoyne, Thomas; Kenny, Bridget-Ann; Hudson, Natalie; Futter, Clare E.; Ambrósio, António F.; Silva, Ana P.; Greenwood, John; Turowski, Patric. "Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells". Neuropharmacology 65 (2013): 74-82. http://dx.doi.org/10.1016/j.neuropharm.2012.08.021.
    Published • 10.1016/j.neuropharm.2012.08.021
  34. Malva, J.O.; Xapelli, S.; Baptista, S.; Valero, J.; Agasse, F.; Ferreira, R.; Silva, A.P.. "Multifaces of neuropeptide Y in the brain: Neuroprotection, neurogenesis and neuroinflammation". Neuropeptides 46 6 (2012): 299-308. http://dx.doi.org/10.1016/j.npep.2012.09.001.
    Published • 10.1016/j.npep.2012.09.001
  35. Gonçalves, Joana; Baptista, Sofia; Olesen, Mikkel V.; Fontes-Ribeiro, Carlos; Malva, João O.; Woldbye, David P.; Silva, Ana P.. "Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment". Journal of Neurochemistry 123 6 (2012): 1041-1053. http://dx.doi.org/10.1111/jnc.12052.
    Published • 10.1111/jnc.12052
  36. Gonçalves, Joana; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P.. "Protective role of neuropeptide Y Y2receptors in cell death and microglial response following methamphetamine injury". European Journal of Neuroscience 36 9 (2012): 3173-3183. http://dx.doi.org/10.1111/j.1460-9568.2012.08232.x.
    Published • 10.1111/j.1460-9568.2012.08232.x
  37. Coelho-Santos, Vanessa; Gonçalves, Joana; Fontes-Ribeiro, Carlos; Silva, Ana Paula. "Prevention of methamphetamine-induced microglial cell death by TNF-a and IL-6 through activation of the JAK-STAT pathway". Journal of Neuroinflammation 9 1 (2012): http://dx.doi.org/10.1186/1742-2094-9-103.
    Published • 10.1186/1742-2094-9-103
  38. Baptista, Sofia; Bento, Ana Rita; Gonçalves, Joana; Bernardino, Liliana; Summavielle, Teresa; Lobo, Andrea; Fontes-Ribeiro, Carlos; et al. "Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures". Neuropharmacology 62 7 (2012): 2413-2423. http://dx.doi.org/10.1016/j.neuropharm.2012.02.015.
    Published • 10.1016/j.neuropharm.2012.02.015
  39. Schitine, Clarissa; Xapelli, Sara; Agasse, Fabienne; Sardà-Arroyo, Laura; Silva, Ana P.; De Melo Reis, Ricardo A.; de Mello, Fernando G.; Malva, João O.. "Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures". European Journal of Neuroscience 35 11 (2012): 1672-1683. http://dx.doi.org/10.1111/j.1460-9568.2012.08072.x.
    Published • 10.1111/j.1460-9568.2012.08072.x
  40. Baptista, S.; Bento, A.R.; Gonçalves, J.; Bernardino, L.; Summavielle, T.; Lobo, A.; Fontes-Ribeiro, C.; et al. "Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures.". Neuropharmacology 62 7 (2012): 2413-2423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871869687&partnerID=MN8TOARS.
  41. Ferreira, Raquel; Santos, Tiago; Cortes, Luísa; Cochaud, Stéphanie; Agasse, Fabienne; Silva, Ana Paula; Xapelli, Sara; Malva, João O.. "Neuropeptide Y inhibits interleukin-1 beta-induced microglia motility". Journal of Neurochemistry 120 1 (2011): 93-105. http://dx.doi.org/10.1111/j.1471-4159.2011.07541.x.
    Published • 10.1111/j.1471-4159.2011.07541.x
  42. Martins, Tânia; Baptista, Sofia; Gonçalves, Joana; Leal, Ermelindo; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; et al. "Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9". Brain Research 1411 (2011): 28-40. http://dx.doi.org/10.1016/j.brainres.2011.07.013.
    Published • 10.1016/j.brainres.2011.07.013
  43. Bento, Ana Rita; Baptista, Sofia; Malva, João O.; Silva, Ana Paula; Agasse, Fabienne. "Methamphetamine Exerts Toxic Effects on Subventricular Zone Stem/Progenitor Cells and Inhibits Neuronal Differentiation". Rejuvenation Research 14 2 (2011): 205-214. http://dx.doi.org/10.1089/rej.2010.1109.
    Published • 10.1089/rej.2010.1109
  44. A. Fontes-Ribeiro, C.; Marques, E.; C. Pereira, F.; P. Silva, A.; R. A. Macedo, T.. "May Exercise Prevent Addiction?". Current Neuropharmacology 9 1 (2011): 45-48. http://dx.doi.org/10.2174/157015911795017380.
    Published • 10.2174/157015911795017380
  45. Silva, Ana Paula. "Metanfetamina e o ciclo do glutamato no cérebro de murganho". Revista Toxicodependências 17 2 (2011): 67-76.
    Open access • Published
  46. Silva AP; Martins T; Baptista S; Gonçalves J; Agasse F; Malva JO. "Brain injury associated with widely abused amphetamines: neuroinflammation, neurogenesis and blood-brain barrier.". (2010): http://europepmc.org/abstract/med/21208167.
  47. Ferreira, Raquel; Xapelli, Sara; Santos, Tiago; Silva, Ana Paula; Cristóvão, Armando; Cortes, Luísa; Malva, João O.. "Neuropeptide Y Modulation of Interleukin-1ß (IL-1ß)-induced Nitric Oxide Production in Microglia". Journal of Biological Chemistry 285 53 (2010): 41921-41934. http://dx.doi.org/10.1074/jbc.m110.164020.
    Published • 10.1074/jbc.m110.164020
  48. Gonçalves, Joana; Baptista, Sofia; Martins, Tânia; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; Malva, João O.; Silva, Ana P.. "Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin". European Journal of Neuroscience 31 2 (2010): 315-326. http://dx.doi.org/10.1111/j.1460-9568.2009.07059.x.
    Published • 10.1111/j.1460-9568.2009.07059.x
  49. Silva, A.P.; Martins, T.; Baptista, S.; Gonçalves, J.; Agasse, F.; Malva, J.O.. "Brain Injury Associated With Widely Abused Amphetamines: Neuroinflammation, Neurogenesis And Blood-Brain Barrier". Current Drug Abuse Reviews 3 4 (2010): 239-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551645771&partnerID=MN8TOARS.
  50. Simões, Patrícia F.; Silva, Ana P.; Pereira, Frederico C.; Marques, Elsa; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; Macedo, Tice R.. "Methamphetamine Changes NMDA and AMPA Glutamate Receptor Subunit Levels in the Rat Striatum and Frontal Cortex". Annals of the New York Academy of Sciences 1139 1 (2008): 232-241. http://dx.doi.org/10.1196/annals.1432.028.
    Published • 10.1196/annals.1432.028
  51. Marques, Elsa; Vasconcelos, Filipa; Rolo, Marta R.; Pereira, Frederico C.; Silva, Ana P.; Macedo, Tice R.; Ribeiro, Carlos F.. "Influence of Chronic Exercise on the Amphetamine-Induced Dopamine Release and Neurodegeneration in the Striatum of the Rat". Annals of the New York Academy of Sciences 1139 1 (2008): 222-231. http://dx.doi.org/10.1196/annals.1432.041.
    Published • 10.1196/annals.1432.041
  52. Gonçalves, Joana; Martins, Tânia; Ferreira, Raquel; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos Fontes; Malva, João O.; Macedo, Tice R.; Silva, Ana P.. "Methamphetamine-Induced Early Increase of IL-6 and TNF-a mRNA Expression in the Mouse Brain". Annals of the New York Academy of Sciences 1139 1 (2008): 103-111. http://dx.doi.org/10.1196/annals.1432.043.
    Published • 10.1196/annals.1432.043
  53. Xapelli, S.; Bernardino, L.; Ferreira, R.; Grade, S.; Silva, A. P.; Salgado, J. R.; Cavadas, C.; et al. "Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia". European Journal of Neuroscience 27 8 (2008): 2089-2102. http://dx.doi.org/10.1111/j.1460-9568.2008.06172.x.
    Published • 10.1111/j.1460-9568.2008.06172.x
  54. Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Grade, S.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R.. "Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory". Neuroscience 150 2 (2007): 433-441. http://dx.doi.org/10.1016/j.neuroscience.2007.09.044.
    Published • 10.1016/j.neuroscience.2007.09.044
  55. Silva, Ana P.; Lourenço, Joana; Xapelli, Sara; Ferreira, Raquel; Kristiansen, Heidi; Woldbye, David P. D.; Oliveira, Catarina R.; Malva, João O.. "Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus". The FASEB Journal 21 3 (2007): 671-681. http://dx.doi.org/10.1096/fj.06-6163com.
    Published • 10.1096/fj.06-6163com
  56. Xapelli, S.; Silva, A.P.; Ferreira, R.; Malva, J.O.. "Neuropeptide Y can rescue neurons from cell death following the application of an excitotoxic insult with kainate in rat organotypic hippocampal slice cultures". Peptides 28 2 (2007): 288-294. http://dx.doi.org/10.1016/j.peptides.2006.09.031.
    Published • 10.1016/j.peptides.2006.09.031
  57. Xapelli, Sara; Agasse, Fabienne; Ferreira, Raquel; Silva, Ana; Malva, Joao. "Neuropeptide Y as an Endogenous Antiepileptic, Neuroprotective and Pro-Neurogenic Peptide". Recent Patents on CNS Drug Discovery 1 3 (2006): 315-324. http://dx.doi.org/10.2174/157488906778773689.
    10.2174/157488906778773689
  58. Silva, A.; Xapelli, S.; Grouzmann, E.; Cavadas, C.. "The Putative Neuroprotective Role of Neuropeptide Y in the Central Nervous System". Current Drug Target -CNS & Neurological Disorders 4 4 (2005): 331-347. http://dx.doi.org/10.2174/1568007054546153.
    Published • 10.2174/1568007054546153
  59. Bernardino, L.. "Modulator Effects of Interleukin-1beta and Tumor Necrosis Factor-alpha on AMPA-Induced Excitotoxicity in Mouse Organotypic Hippocampal Slice Cultures". Journal of Neuroscience 25 29 (2005): 6734-6744. http://dx.doi.org/10.1523/jneurosci.1510-05.2005.
    Published • 10.1523/jneurosci.1510-05.2005
  60. Silva, Ana P.; Xapelli, Sara; Pinheiro, Paulo S.; Ferreira, Raquel; Lourenco, Joana; Cristovao, Armando; Grouzmann, Eric; et al. "Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats". Journal of Neurochemistry 93 1 (2005): 163-170. http://dx.doi.org/10.1111/j.1471-4159.2004.03005.x.
    Published • 10.1111/j.1471-4159.2004.03005.x
  61. Rego, A. Cristina; Monteiro, Nuno M.; Silva, Ana P.; Gil, Joana; Malva, João O.; Oliveira, Catarina R.. "Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures". Journal of Neurochemistry 86 4 (2003): 792-804. http://dx.doi.org/10.1046/j.1471-4159.2003.01898.x.
    Published • 10.1046/j.1471-4159.2003.01898.x
  62. SILVA, ANA P.; PINHEIRO, PAULO S.; CARVALHO, ARSÉLIO P.; CARVALHO, CAETANA M.; JAKOBSEN, BIRTHE; ZIMMER, JENS; MALVA, JOÃO O.. "Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures". The FASEB Journal 17 9 (2003): 1118-1120. http://dx.doi.org/10.1096/fj.02-0885fje.
    Published • 10.1096/fj.02-0885fje
  63. Silva, A. "Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus". Neuropharmacology 44 2 (2003): 282-292. http://dx.doi.org/10.1016/s0028-3908(02)00382-9.
    Published • 10.1016/s0028-3908(02)00382-9
  64. Pinheiro, Paulo S.; Rodrigues, Ricardo J.; Silva, Ana P.; Cunha, Rodrigo A.; Oliveira, Catarina R.; Malva, João O.. "Solubilization and immunological identification of presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat hippocampus". Neuroscience Letters 336 2 (2003): 97-100. http://dx.doi.org/10.1016/s0304-3940(02)01217-x.
    Published • 10.1016/s0304-3940(02)01217-x
  65. Malva, J.O.; Silva, A.P.; Cunha, R.A.. "Presynaptic modulation controlling neuronal excitability and epileptogenesis: Role of kainate, adenosine and neuropeptide Y receptors". Neurochemical Research 28 10 (2003): 1501-1515. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141593557&partnerID=MN8TOARS.
    10.1023/A:1025618324593
  66. Silva, Ana P.; Carvalho, Arsélio P.; Carvalho, Caetana M.; Malva, João O.. "Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus". Journal of Neurochemistry 79 2 (2001): 286-296. http://dx.doi.org/10.1046/j.1471-4159.2001.00560.x.
    10.1046/j.1471-4159.2001.00560.x
  67. Silva, Ana P.; Malva, João O.; Ambrósio, António F.; Salgado, António J.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Role of kainate receptor activation and desensitization on the [Ca2+]ichanges in cultured rat hippocampal neurons (IF: 3.378)". Journal of Neuroscience Research 65 5 (2001): 378-386. http://dx.doi.org/10.1002/jnr.1164.
    Published • 10.1002/jnr.1164
  68. Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels". Biochemical Pharmacology 61 10 (2001): 1271-1275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035873841&partnerID=MN8TOARS.
    10.1016/S0006-2952(01)00584-6
  69. Ambrósio, António F; Silva, Ana P; Araújo, Inês; Malva, João O; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P; Carvalho, Caetana M. "Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024". European Journal of Pharmacology 406 2 (2000): 191-201. http://dx.doi.org/10.1016/s0014-2999(00)00659-2.
    10.1016/s0014-2999(00)00659-2
  70. Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Mesquita, José F.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]ichanges in cultured rat hippocampal neurons". European Journal of Neuroscience 12 6 (2000): 2021-2031. http://dx.doi.org/10.1046/j.1460-9568.2000.00091.x.
    Published • 10.1046/j.1460-9568.2000.00091.x
  71. Ambrósio, A.F.; Silva, A.P.; Araújo, I.; Malva, J.O.; Soares-da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024". European Journal of Pharmacology 406 2 (2000): 191-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034644868&partnerID=MN8TOARS.
    10.1016/S0014-2999(00)00659-2
  72. Ambrósio, A.F.; Silva, A.P.; Malva, J.O.; Soares-Da-Silva, P.; Carvalho, A.P.; Carvalho, C.M.. "Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists". Neuropharmacology 38 9 (1999): 1349-1359. http://www.scopus.com/inward/record.url?eid=2-s2.0-18244425608&partnerID=MN8TOARS.
    10.1016/S0028-3908(99)00058-1
Thesis / Dissertation
  1. Silva, Ana Paula. "Neurotoxicity and neuroprotection in the hippocampus: Role of neuropeptide Y receptors". PhD, Universidade de Coimbra, 2003.

Intellectual property

Patent
  1. Malva JO; Schitine C; Agasse F; Xapelli S; Silva AP; Reis R. 2010. "Process for treating neural stem cells based on ampakines and/or other modulators of ionotropic glutamate receptors, compositions thereof and their use in CNS conditions". Portugal.
    Expired
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/09 Neurobiology of Addiction: The importance of pre-clinical research Meeting of the Portuguese Association of Addictology
(Ílhavo, Aveiro, Portugal)
2024/02/09 UNVEILLING THE IMPACT OF METHYLPHENIDATE MISUSE ON THE RETINA 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
Portuguese Society of Pharmacology (Lisboa, Portugal)
2023/11/24 The neurobiology of Attention-Deficit/Hyperactivity Disorder (ADHD) and the effect of methylphenidate: a pre-clinical study Meeting of the Portuguese Societey of Psychiatry
(Albufeira, Portugal)
2022/11/18 Psychostimulants and the brain Congresso Nacional de Neurologia
Sociedade Portuguesa de Neurologia (Aveiro, Portugal)
2022/11/10 ADHD and The Retina 5º Congresso Nacional PHDA
(Porto, Portugal)
2022/02/11 UNVEILLING THE EFFECT OF METHYLPHENIDATE ON THE RETINA OF CONTROL AND ATTENTION-DEFICIT/HYPERACTIVITY DISORDER RATS 52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia
(Porto)
2021/02/19 IMPACT OF METHYLPHENIDATE ON THE RETINA IN CONTROL AND ADHD CONDITIONS SPF 2021 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2020/12/10 Manipulation of the BBB - a barrier or a door? Workshop in translational Neurology, Blood-Brain Barrier in the Clinics
NANOSTEM project (H2020; GA764958)
2020/02/05 IMPACT OF TRAUMATIC BRAIN INJURY ON ASTROCYTES: ROLE OF NEUROPEPTIDE Y 50.ª Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2020/02/05 VGF-secreted peptide derived from brain metastatic breast cancer cells induces brain endothelial cells dysfunction 50ª Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2019/07/10 RhoA signaling in microglia and the impact for neurodegeneration. XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019/05/15 Impact of methylphenidate on the neurovascular unit Seminar at the Coimbra Institute for Clinical and Biomedical Research (iCBR)
(Coimbra, Portugal)
2019/05/10 Neurovascular alterations induced by methylphenidate: Attention deficit and hyperactivity disorder versus Control CIBB Neuroscience and Disease – Retreat
(Miranda do Corvo, Portugal)
2019/05/10 Adenosine deaminase 2 deficiency (DADA2): the importance of multidimensional approach and future perspective on clinical and translational research CIBB Neuroscience and Disease – Retreat
(Miranda do Corvo, Portugal)
2018/07/10 Effects of high-fat and hypoproteic diets on hippocampal blood-brain barrier permeability and oxidative stress I Simpósio Luso-Brasileiro de Neurociências e II Simpósio Internacional em Neurociências
(Fortaleza, Brazil)
2018/07/07 Unmasking the impact of methylphenidate on blood-brain barrier function: in vitro and animal studies. 43rd FEBS Congress
(Prague, Czech Republic)
2018/07/07 Neurogliovascular alterations triggered by early developmental chronic consumption of methylphenidate 43rd FEBS Congress
(Pragha, Czech Republic)
2018/07/03 Impact of Psychostimulants on Blood-Brain Barrier Function: Focus on Methamphetamine and Methylphenidate. Graduate Programme in Areas of Basic and Applied Biology (GABBA)
i3S, University of Porto
2018/05/10 An eye on ADHD: can the retina be used as a diagnostic support tool? 1st ADHD National meeting
(Coimbra, Portugal)
2018/02/23 Impact of methamphetamine on the hippocampal neuropeptide Y system: Endothelial protective role VII in4Med, Medical and Scientific Meeting, NEM/AAC
(Coimbra, Portugal)
2018/02/05 Parthenolide as a new protective approach against neurovascular unit dysfunction induced by methamphetamine XLVIII Meeting of the Portuguese Society of Pharmacology
(Lisbon, Portugal)
2017/06/26 Brain immune response triggered by early developmental chronic consumption of methylphenidate: control vs attention-deficit/hyperactivity disorder rat model XXVI AINI congress and 16th ESNI Course
(Venice, Italy)
2017/06/22 ADHD and substance use: Neurobiology VII National Meeting of Dual Pathology
(Liboa, Portugal)
2017/05/25 Excitation/inhibition balance and glial function in mouse model of neurofibromatosis type 1: distinct susceptibility of hippocampus, prefrontal cortex and striatum XV Meeting of the Portuguese Society for Neuroscience
(Braga, Portugal)
2017/05/19 The impact of psychostimulants in the brain: Use and Abuse. Seminar Neurosciences, Faculty of Medicine, University of Coimbra
(Coimbra, Portugal)
2017/02/02 IMPACT OF METHAMPHETAMINE ON BLOOD-BRAIN BARRIER: ROLE OF EXERCISE XLVII Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2017/02/02 INTERLEUKINE-6 IS INVOLVED IN BLOOD-BRAIN BARRIER DYSFUNCTION IN BRAIN TUMORS: IN VITRO STUDY XLVII Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2017/02/02 Can parthenolide prevent methamphetamine-induced neurovascular dysfunction? XLVII Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2017/02/02 Impact of chronic methylphenidate administration in rat brain immune surveillance: control versus ADHD XLVII Meeting of Portuguese Society of Pharmacology, XXXV Meeting of Clinical Pharmacology and XVI Meeting of Toxicology
(Coimbra, Portugal)
2017/02/02 Peripheral inflammation inhibits hippocampal neurogenesis and decreases spatial memory performance in adult mice – Lessons for human brain healthy ageing XLVII Meeting of Portuguese Society of Pharmacology
(Coimbra, Portugal)
2016/11/02 Impact of psychostimulants on the neurogliovascular unit: Methamphetamine and Methylphenidate. I Symposium, Portuguese Glial Network
(Braga, Portugal)
2016/09 Brain and ADHD EQUIPA SAUDE MENTAL COMUNITÁRIA PINHAL INTERIOR NORTE COMEMORAÇÃO DO Iº ANIVERSÁRIO, HIPERATIVIDADE E DEFICIT DE ATENÇÃO: DOS MITOS AO CONHECIMENTO CIENTIFICO
(Oliveira do Hospital, Portugal)
2016/06/28 Impact of Methamphetamine on Blood-Brain Barrier Function Graduate Programme in Areas of Basic and Applied Biology (GABBA)
IBMC, University of Porto
2016/02/04 Impact of chronic methylphenidate administration on behavior, blood-brain barrier function and neuroinflammation: control versus hyperactive rats XLVI Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXIV Reunião De Farmacologia Clínica, XV Reunião de Toxicologia.
(Porto, Portugal)
2015/12/03 Blood-brain barrier dysfunction and neuroinflammation triggered by chronic methamphetamine self-administration in rats II Annual Meeting of IBILI
(Coimbra, Portugal)
2015/10/16 The impact of psychostimulants on blood-brain barrier function. Seminar CNC.IBILI
University of Coimbra
2015/09/24 Methamphetamine self-administration leads to blood-brain barrier dysfunction: an animal study Lisbon Addiction 2015
(Lisbon, Portugal)
2015/06/25 Impact of Methamphetamine on Blood-Brain Barrier Function. Graduate Programme in Areas of Basic and Applied Biology (GABBA)
IBMC, University of Porto
2015/06 The impact of methamphetamine on blood-brain barrier function: What is the role of inflammatory mediators? XIV Meeting of the Portuguese Society for Neurosciences
(Póvoa do Varzim)
2015/02/04 Methamphetamine induces brain edema and blood-brain barrier disruption by aquaporin 4 via protein kinase C pathway XLV Meeting of Portuguese Society of Pharmacology
(Lisbon, Portugal)
2014/11 Understanding the effect of amphetamines: the importance of fundamental research National Congress of Psychiatry
(Vilamoura)
2014/07/13 Brain edema and blood-brain barrier breakdown induced by methamphetamine: role of aquaporin 4. Summer Course, University Pompeu Fabra, Spain, partnered with the Cold Spring Harbor Laboratory, USA
(Barcelona, Spain)
2014/06/26 Impact of methamphetamine on the blood-brain barrier function Graduate Programme in Areas of Basic and Applied Biology (GABBA)
IBMC, University of Porto
2014/05/14 Drugs abuse toxicity Neuropathology and Neuropharmacology, Master in Biopharmaceutical Sciences
Faculty of Pharmacy, University of Lisbon
2014/02/05 Methamphetamine induces alterations in brain water homeostasis: role of aquaporin 4 XLIV Meeting of Portuguese Society of Pharmacology, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
(Coimbra, Portugal)
2013/11 Methamphetamine-induced brain changes (Alterações no cérebro induzidas por metanfetamina) National Congress of Addictology
(Aveiro, Portugal)
2013/09/11 Methamphetamine causes neuroinflammation and blood-brain barrier dysfunction in mouse hippocampus. FENS Featured Regional Meeting
(Prague, Czech Republic)
2013/09 Methamphetamine induces blood-brain barrier dysfunction: role of TNF-alfa Red de Transtornos Adictivos, Reunión Científica 2013
(Oviedo, Spain)
2013/06/09 Drugs of abuse and the functional brain ADVANCED COURSE Pharmacological Development: from Organic Synthesis to Clinical Trials
University of Minho, Braga, Portugal
2013/05/28 Impact of methamphetamine on the blood-brain barrier function Graduate Programme in Areas of Basic and Applied Biology (GABBA)
IBMC, University of Porto
2013/04/10 Seminar entitled "Brain dysfunction induced by methamphetamine" at the University of Minho, Braga, Portugal IV Jornadas de Bioquímica
Universidade do Minho, Braga, Portugal
2013/03/09 Presentation of the Research Office of the Faculty of Medicine, University of Coimbra (GAI) at the “I Simpósio Inter-Universitário de Investigação em Medicina Dentária” I Simpósio Inter-Universitário de Investigação em Medicina Dentária
2012/06/30 MULTIFACETED NPY: NEUROGENESIS, NEUROINFLAMMATION AND NEUROPROTECTION. 10th International NPY-PYY-PP Meeting
(Montréal, Canada)
2012/06/19 Impact of methamphetamine on blood-brain barrier function. Graduate Programme in Areas of Basic and Applied Biology (GABBA)
IBMC, University of Porto
2012/02 Amphetamines and the Human Brain 2nd Congress of National Dual Pathology
(Coimbra, Portugal)
2011/12 Impact of methamphetamine on the Central Nervous System 3rd IBILI Meeting, University of Coimbra
(Coimbra, Portugal)
2011/05 Impact of methamphetamine on blood-brain barrier permeability Symposium Barrier Systems in Health and Disease, Faculty of Pharmacy, University of Lisbon,
(Lisboa, Portugal)
2010/12/16 Animal Models in Behaviour Diseases PhD programme in Health Sciences
Faculty of Medicine, University of Coimbra
2010/09 Methamphetamine increases blood brain-barrier permeability and lymphocyte migration: involvement of tight junction proteins and endothelial nitric oxide synthase. I International meeting of Health Gaia-Porto, College of Health and Technology
(Vila Nova de Gaia, Portugal)
2010/04 Methamphetamine: the dangerous! Workshop "News about Animal Experimentation", Faculty of Pharmaceutical Sciences, University of Coimbra
(Coimbra)
2010/01 Brain damages induced by methamphetamine: blood brain-barrier, neuroinflammation and neurogeneses. Workshop "Brain and desire", Bissaya barreto Foundation, Bencanta
(Bencanta, Coimbra, Portugal)
2008/10 Effect of Methamphetamine on the Central Nervous System Simposium "Olhares cruzados sobre as Drogas em Portugal II"
(Sesimbra, Portugal)
2008/03/31 Drugs of abuse and neuroinflammation Course of “Neuroimmunology” , PhD Programme in Experimental Biology and Biomedicine (PDBEB)
Centre for Neuroscience and Cell Biology (CNC), University of Coimbra
2007/12/05 Methamphetamine-induced changes in pro-inflammatory cytokines mRNA and tight junction proteins in the mice hippocampus, frontal cortex and striatum. XXXVIII Meeting of Portuguese Society of Pharmacology
2007/03 The role of neuroinflammation in methamphetamine-induced brain damage Simpósio "Olhares cruzados sobre as Drogas em Portugal"
(Sesimbra, Portugal)
2006/01/16 Synaptic modulation and excitotoxicity Course of “Neuromodulation” , PhD Programme in Experimental Biology and Biomedicine (PDBEB)
2006/01 Effect of methamphetamine administration on rat hippocampal glutamate receptor expression levels: possible implication for memory impairment (Efeito da administração de metanfetamina nos níveis de expressão dos receptores do glutamato no hipocampo de rato: possível implicação para a alteração da memória) Encontro do Centro de Atendimento a Toxicodependentes (CAT)
(Coimbra, Portugal)
2005/12/05 Neuropeptide Y modulates glutamate release in the hippocampus of kainate-induced epileptic rats: Involvement of protein kinase C XXXVI Meeting of Portuguese Society of Pharmacology
2004/12 Neuroprotection mediated by neuropeptide Y receptors in the hippocampus. XIV National Congress of Biochemistry
(Vilamoura, Portugal)
2004/02/03 Involvement of hippocampal neuropeptide Y receptors in mediating neuroprotection under excitotoxic conditions 7th International NPY Meeting
2002/06/14 Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. 16ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
2001/12/03 Modulation of glutamate release by neuropeptide Y1, Y2 and Y5 receptor activation in rat hippocampal synaptosomes XXXII Meeting of Portuguese Society of Pharmacology
2001/09 Modulation of calcium influx and glutamate release by neuropeptide Y1 and Y2 receptors in the hippocampus: differential effects in CA1, CA3 and dentate gyrus 7th Meeting of the Portuguese Neuroscience Society
(Luso, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Bioactive compounds, present in Mediterranean diet, able to modulate neurogenesis and neuroinflammation with potential to promote healthy cerebral ageing (PhD; Research Grant L.884092)
Supervisor
Universidade de Coimbra, Portugal
2021/09/01 - Current Retinal alterations in Attention-deficit/Hyperactivity Disorder: the use and misuse of methylphenidate (PhD)
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09 - Current Emerging Multiple Sclerosis therapies to the test: tracking immune cell trafficking, induced molecular mechanisms and aftermath effects (PhD)
Co-supervisor
 Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - 2024/02/19 Unravel the role of pericytes in endothelial cell dysfunction induced by brain metastatic breast cancer cells (MSc)
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/10/23 Crosstalk between neutrophils and brain endothelial cells in a context of traumatic brain injury: Role of CXCL8-CXCR2 axis (MSc)
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/10/16 Blood-brain barrier dysregulation induced by acute stress: role of neuroinflammation (MSc)
Supervisor
 Neurociências Molecular e de Translação (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/09/28 Inflammatory mechanisms of blood-brain barrier damage in drug abuse (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09/01 - 2022/10/13 Impact of chronic stress in blood-brain barrier: focus on C3 complement pathway and sex differences (MSc)
Supervisor
 Neurociências Molecular e de Translação (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/01/01 - 2021/12/09 NEUROPEPTIDE RESPONSE IN TRAUMATIC BRAIN INJURY (PhD)
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/09/07 - 2021/02/01 Impact of Traumatic brain injury in the hippocampus - Institute for Life Sciences and Chemistry, Hogeschool Utrecht, Netherlands (BSc, final project)
Co-supervisor
Hogeschool Utrecht, Netherlands
2019/09/01 - 2020/11/27 METHYLPHENIDATE-INDUCED ALTERATIONS IN ASTROCYTES: A COMPREHENSIVE CHARACTERIZATION (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09/01 - 2019/09/20 Exploring the expression of the NLRP3 inflammasome in reactive astrocytes (MSc)
Co-supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/09/01 - 2019/09/13 Impact of traumatic brain injury on Astrocytes: role of neuropeptide Y (MSc)
Supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/09/01 - 2019/09/09 EFFECT OF METHYLPHENIDATE ON MICROGLIA: TRACKING DIRECT AND BRAIN ENDOTHELIAL CELLS-MEDIATED CHANGES (MSc)
Supervisor
 Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/04/29 - 2019/07/31 Impact of methamphetamine on astrocytes: protective role of parthenolide (BSc, final project)
Supervisor
 Biotecnologia (Degree)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019/02/01 - 2019/06/30 Effect of methylphenidate on the brain: focus on endothelial cells and microglia (BSc, final project)
Supervisor
 Química Medicinal (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/04/01 - 2018/02/22 Effect of methylphenidate on blood-brain barrier function in health and attention deficit hyperactivity disorder (PhD)
Supervisor
 Envelhecimento e Doenças Crónicas (associação) (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/01/01 - 2017/10/17 Role of aquaporin-4 in methamphetamine-induced blood-brain barrier dysfunction and cerebral edema formation (PhD)
Supervisor
 Engenharia Biomédica (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/01 - 2017/09/29 Impact of Methylphenidate on Microglial cells (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/05/01 - 2017/06/06 Impact of methamphetamine on the hippocampal neuropeptide Y system: Endothelial protective role (MSc)
Supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/01 - 2016/09/26 Impact of methamphetamine on blood-brain barrier : role of exercice (MSc)
Co-supervisor
 Medicina do Desporto (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/01 - 2016/09 ROLE OF MICROGLIA-MEDIATED NEUROINFLAMMATION IN DYSFUNCTION OF BLOOD-BRAIN BARRIER IN GLIOBLASTOMA (MSc)
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/04/01 - 2015/02/11 The effect of methamphetamine on dentate gyrus neurogenesis: role of neuropeptide Y (PhD)
Supervisor
 Ciências da Saúde (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09/01 - 2013/09 Effect of methamphetamine on microglial and endotelial cells: nitrosative and oxidative stress (MSc)
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/09/01 - 2013/07 Response of glioblastoma cells to doxorubicin and methotrexate : role of methamphetamine (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/01/01 - 2012/12/14 Impact of Methamphetamine on the Blood-Brain Barrier Function (PhD)
Supervisor
 Ciências Biomédicas (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/01/01 - 2012/12/05 Methamphetamine-Induced Hippocampal Dysfunction: the role of Pro-Inflammatory Cytokines and Neuropeptide Y (PhD)
Supervisor
 Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/09/01 - 2012/07 Impact of methamphetamine on astrocytes and endothelial cells : role of aquaporin-4 (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09/01 - 2011/07 Role of interleukin-6 in methamphetamine-induced toxicity (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010/09/01 - 2011/07 Effect of methamphetamine on the crosstalk between endothelial cells and astrocytes (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09/01 - 2010/09 Differential effects of methamphetamine in frontal cortex and striatum: focus on astrogliosis and cell death (MSc)
Supervisor
 Biologia (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005/10/01 - 2010/07/20 Unravelling a functional interaction between kainate receptors and the endocannabinoid system (PhD)
Supervisor
 Biologia (Biologia Celular) (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/09/01 - 2009/09 The effect of methamphetamine on dentate gyrus neurogenesis: role of neuropeptide Y (MSc)
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008/09/01 - 2009/09 The effect of methamphetamine on subventricular zone neurogenesis: cell death, proliferation and differentiation (MSc)
Supervisor
 Engenharia Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/09 - 2023/03/10 Symposium Clearing the Smoke on Medical Cannabis: The importance of the Endocannabinoid System in Health and Disease (2023/03/09 - 2023/03/10)
Symposium (Other)
2023/02/01 - 2023/02/03 Organizing Committe of the Portuguese Society of Pharmacology Meeting (2023/02/01 - 2023/02/03)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2021/12/01 - 2021/12/03 XVII Meeting of the Portuguese Society of Neuroscience (2021/12/01 - 2021/12/03)
Congress (Member of the Organising Committee)
2021/11/30 - 2021/11/30 V Symposium of the Portuguese Glial Network (2021/11/30 - 2021/11/30)
Symposium (Member of the Organising Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2021/02/10 - 2021/02/10 Seminar by Milene Gonçalves entitled "Kynurenine Pathway in Peripheral Immune System in Parkinson´s disease" (2021/02/10) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/11/18 - 2020/11/18 Seminar by Alejandro Higuera Matas (School of Psychology, National University for Distance Learning (UNED), Madrid, Spain): "Double-hit animal models of neurodevelopmental disorders: a focus on schizophrenia" (2020/11/18) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/05/08 - 2020/05/08 Neuroscience and Disease Thematic Line Retreat, Center for Innovative Biomedicine and Biotechnology (CIBB) (2020/05/08 - 2020/05/08)
Symposium
 Universidade de Coimbra, Portugal
2019/11 - 2019/11 Science and Technology Week (2019) at the Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra - Seminar and Lab experiments for school students (all levels) (2019/11 - 2019/11) Ciência Viva, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2018/12/21 - 2018/12/21 2nd Meeting on Biomedical Research @UC, Coimbra, Portugal (2018/12/21 - 2018/12/21)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11 - 2018/11 Science and Technology Week (2018) at the Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra - Seminar and Lab experiments for school students (all levels) (2018/11 - 2018/11) Ciência Viva, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2018/06/22 - 2018/06/22 Seminar by Adelaide Fernandes (iMed. ULisboa, University of Lisbon): Neuroinflammation in Mutiple Sclerosis: from target discovery to development of a therapeutic strategy (2018/06/22 - 2018/06/22)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2017/11 - 2017/11 Science and Technology Week (2017) at the Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra - Seminar and Lab experiments for school students (all levels) (2017/11 - 2017/11) Ciência Viva, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2016/12/19 - 2016/12/20 1st Meeting on Biomedical Research @UC, Coimbra, Portugal, 19-20 de dezembro de 2016. (2016/12/19 - 2016/12/20)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2015/11/06 - 2015/11/06 Seminar by Teresa Summavielle (University of Porto): "Methamphetamine at the cytoskeletal level: morphologic, molecular and behavioural effects" (2015/11/06 - 2015/11/06)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2015/06/04 - 2015/06/05 XIV Meeting of The Portuguese Society for Neuroscience, Póvoa do Varzim, Portugal (2015/06/04 - 2015/06/05)
Congress (Member of the Scientific Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/04/18 - 2015/04/18 Organization of an Workshop for Medical students (PET/T4PE, International Department of Medical Students Association - DMI - NEM/AAC) (2015/04/18 - 2015/04/18) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/02/11 - 2015/02/11 Seminar by Alberto Bacci (Institut du Cerveau et de la Moelle épinière (ICM), Paris, France): "Long-term Plasticity of Neocortical GABAergic Synapses" (2015/02/11 - 2015/02/11)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05/24 - 2014/05/24 Organization of an Workshop for Medical students (PET/T4PE, International Department of Medical Students Association - DMI - NEM/AAC) (2014/05/24 - 2014/05/24) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/05/30 - 2013/06/01 XIII Meeting of The Portuguese Society for Neuroscience, Luso, Portugal (2013/05/30 - 2013/06/01)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2012/12/06 - 2012/12/07 IV Annual Meeting of Coimbra Institute for Clinical and Biomedical Research (former IBILI), From Cell Biology to In Vivo Molecular and Functional Imaging, Coimbra, 6 e 7 de dezembro de 2012. (2012/12/06 - 2012/12/07)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2012/02/08 - 2012/02/08 Seminar by Maria Alexandra Brito (Faculty of Pharmacy, University of Lisbon): "Blood-brain barrier disruption by neurotoxins and protection by bile acids", Faculdade de Medicina,Universidade de Coimbra, 8 de fevereiro de 2012. (2012/02/08 - 2012/02/08)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2011/02/02 - 2011/02/04 XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia (2011/02/02 - 2011/02/04)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Farmacologia, Portugal
2010/12/10 - 2010/12/11 II Annual Meeting of Coimbra Institute for Clinical and Biomedical Research (former IBILI) (2010/12/10 - 2010/12/11)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2009/12/11 - 2009/12/13 I Annual Meeting of the Coimbra Institute for Clinical and Biomedical Research (former IBILI) (2009/12/11 - 2009/12/13)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Faculdade de Medicina, Portugal
2008/07/06 - 2008/07/06 Seminar by Giovanni Marsicano (NeuroCentre Magendie, U862 INSERM, Bordeaux University, France): “Genetic dissection of the physiological functions of the endocannabinoid system” (2008/07/06 - 2008/07/06)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/05/06 - 2005/05/06 Seminar by David P. D. Woldbye (Laboratory of Neuropsychiatry, University of Copenhagen, Denmark): “Neuropeptide Y and seizures” (2005/05/06 - 2005/05/06)
Seminar (President of the Organising Committee)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/02/03 - 2004/02/07 7th International NPY Meeting (2004/02/03 - 2004/02/07)
Congress (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/09/27 - 2024/09/27 European Research Night 2024
Ciência Viva, Portugal
2022/02/22 - 2022/02/22 Doctoral Supervision Seminar: approaches and practices - Doctoral Schools Edition
Seminar
Universidade de Coimbra, Portugal
2021/09/24 - 2021/09/24 European Researchers' Night
Meeting
 European Researchers' Night
2021/02/17 - 2021/02/19 SPF 2021 Meeting of the Portuguese Society of Pharmacology
Congress
2020/12/10 - 2020/12/11 Workshop in Translational Neurology, Blood-Brain Barrier in the Clinical setting (Project NanoStem H2020)
Workshop
2020/11/05 - 2020/11/06 3rd National Congress of ADHD
Congress
2020/01/17 - 2020/03/31 Brain Awareness Week (2020) - High School students (Seminar and experimental activities)
Meeting
2019/11 - 2019/11 Science and Technology Week (2019) - Seminar for High School students
Seminar
2019/09/23 - 2019/09/23 Workshop AGENDA - Innovative Proposal Writing tecnhiques: a sound theoretical and practical approach
Workshop
 AGENDA - Innovative Proposal Writing tecnhiques: a sound theoretical and practical approach
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/09 - 2019/09 European Researchers' Night, at the Botanic Garden and Science Museum (Coimbra)
2019/06/28 - 2019/06/29 Conference "Ageing: models, mechanisms and therapies" - EraChair@UC
Conference
 Ageing: models, mechanisms and therapies
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/06/06 - 2019/06/06 Demonstrador Tecnológico - Agência Nacional de Inovação (ANI) Transferência de Tecnologia em Saúde
Symposium
 Demonstrador Tecnológico - Agência Nacional de Inovação (ANI) Transferência de Tecnologia em Saúde
Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
2019/05/29 - 2019/05/29 Portuguese Glial network - IV Symposium Glial Diversity in Neuromodulation and Neurodegeneration
Symposium
 Portuguese Glial network - IV Symposium, Glial Diversity in Neuromodulation and Neurodegeneration
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/03 - 2019/03 Brain Awareness Week (2019) - High School students (Seminar and experimental activities)
2018/09 - 2018/09 European Researchers' Night, at the Botanic Garden and Science Museum (Coimbra)
2018/03 - 2018/03 Brain Awareness Week (2018) - High School students (Seminar and experimental activities)
2017/03 - 2017/03 Brain Awareness Week (2017) - High School students (Seminar and experimental activities)
2016/03 - 2016/03 Brain Awareness Week (2016) - High School students (Seminar and experimental activities)
2015/03/17 - 2015/03/17 Brain Awareness Week (2015) - High School students (Seminar and experimental activities)
2014/11/27 - 2014/11/27 Science and Technology Week (2014) - Seminar and Lab experiments for High School students
2014/03/11 - 2014/03/11 Brain Awareness Week (2014) - High School students (Seminar and experimental activities - Colégio São Teotónio, Coimbra).
2013/11/18 - 2013/11/18 Science and Technology Week (2013) - Seminar for High School students
2012/01/11 - 2012/01/11 Activities with Kindergarten Students regarding the study of the brain - Neuroscience for kids (Colégio Rainha Santa Isabel, Coimbra)
2011/05/20 - 2011/05/20 Seminar to high school students about "Drugs of abuse and the brain" at "Escola Secundária Infanta D. Maria, Coimbra". Invitation by the Students Association of this school.
2011/03/18 - 2011/03/18 Brain Awareness Week (2011) - Seminar entitled “Drugs of abuse and the brain" for High School Students (Escola Secundária Raul Proença, Caldas da Rainha).
2011/03/07 - 2011/03/07 Brain Awareness Week (2011) - Seminar entitled “Drugs of abuse research" for University Students (Catolic University of Viseu)
2011/03 - 2011/03 Brain Awareness Week (20011) - High School students had the opportunity to visit the Lab. This event was published in a local journal. http://raulmedical.blogspot.com/2011/03/visita-ao-ibili-destacada-na-gazeta-das.html
Workshop
2010/04/15 - 2010/04/15 Seminar entitled "Methamphetamine: the dangerous!" within the “Workshop –Atualidade em Experimentação Animal” organized by the Center for Pharmaceutical Studies (Faculdade de Farmácia, Universidade de Coimbra)
2010/03/19 - 2010/03/19 Brain Awareness Week (2010) - Elementary School students (Seminar and experimental activities at Escola EB1 de Montemor-o-Velho)
2010/03/18 - 2010/03/18 Brain Awareness Week (2010) - High School students (Seminar and lab activities at Escola Secundária da Moita, Moita)
2009/04/15 - 2009/04/15 Seminar entitled "Drugs and the brain" to high school students within the "Health and Education Week" organized by Escola Secundária Avelar Brotero, Coimbra.
2009/03/05 - 2009/03/05 Seminar entitled "Amphetamines Neurotocixity" in a round table about drugs of abuse “Drogas de Abuso: Drogas leves, não tão leves...; Introdução às Ciências Forenses e Neurociências, Ciclo de Conferências e Debates”, organized by the Biology Students Association (University of Coimbra)
2008/03/13 - 2008/03/13 Brain Awareness Week (2008) - Seminar to the general public at the Science Museum in Coimbra (http://www.museudaciencia.org/)
2008 - 2008 Participation in the "Scientist Blog”, an initiative coordinated by the Education and Communication Department, Knowledge Pavilion (Pavilhão do Conhecimento). The participants had the opportunity to ask questions to scientists and discuss several topics of their interest.
2005/03 - 2005/03 Brain Awareness Week (2005) - Neuroscience for kids (Kindergarten Students)
Workshop
2004/03 - 2004/03 Brain Awareness Week (2004) - Neuroscience for kids (Elementary Schools)
Workshop
2000 - 2000 Participation in the project “Health in the XXI Century, a Vision from the European Youth”. Dissemination of science/research to the general public (High Schools)
Round table
 http://www.cienciaviva.pt/healthXXI/dmaria/index.asp?lang=en

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/06 Impacto do stress pré-natal nas sinapses e na barreira hematoencefálica do córtex pré-frontal
(Thesis) Main arguer
 Daniela Carvalho Lopes (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2024/10/28 EXPLORING THE ROLE OF CCR5 IN METHAMPHETAMINE-INDUCED NEUROVASCULAR ALTERATIONS
Supervisor
 Amélia de Jesus Lemos Ormonde (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023/11/27 Therapeutic application of Argonaute-2 to enhance neurovascular repair and inflammatory restitution in stroke
(Thesis) Main arguer
 Marta Sofia Machado Pereira (PhD)
Universidade da Beira Interior, Portugal
2023/11/09 IFN¿ as a modulator of Methamphetamine induced neuroinflammation
(Thesis) Main arguer
 João Paulo Alves Rodrigues (Master)
Universidade do Porto, Portugal
2023/10/31 UNDERSTANDING THE ROLE OF ASTROGLIOGENESIS ON BRAIN PHYSIOLOGY AND BEHAVIOR
(Thesis) Main arguer
 Gonçalo Ferreira (Master)
Universidade de Coimbra, Portugal
2023/05/15 Psychostimulants and neuroinflammation: finding critical players in the crosstalk between glial cells and neurons (PhD)
(Thesis) Arguer
 Joana Catarina Silva Bravo (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02/22 ANÁLISE DO CONSUMO DE MEDICAMENTOS NA PERTURBAÇÃO DE HIPERATIVIDADE E DÉFICE DE ATENÇÃO EM PORTUGAL (MSc)
(Thesis) Main arguer
 Rodrigo Neves Ferreira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/12/06 EVALUATING THE POTENTIAL OF MESENCHYMAL STROMAL CELLS FOR PROMOTING ALLEVIATION OF BLOOD-BRAIN BARRIER IMPAIRMENTS IN MACHADO-JOSEPH DISEASE (MSc)
(Thesis) Main arguer
 Daniela Jacinto Gonzaga (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/10/13 Effect of neuropeptide Y intranasal delivery in autistic-like behaviors in a mouse model of autism spectrum disorder (MSc)
(Thesis) Main arguer
 Ana Margarida da Silva Pinho (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/29 The role of aging-related microglia dysfunction in the neurodegenerative process of Machado-Joseph disease (PhD)
(Thesis) Main arguer
 Ana Bela Saraiva de Campos (PhD)
Universidade do Minho Escola de Ciências da Saúde, Portugal
2022/06/06 Dissecting the link between allergies and ADHD: a focus on IL-4 (MSc)
(Thesis) Main arguer
 VIKTORIYA SHKATOVA (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/01/14 Unveiling the cellular and molecular players involved in methamphetamine-induced neuroinflammation: focus on astrocyte-microglial crosstalk (PhD)
(Thesis) Main arguer
 Teresa Correia Soares Canedo (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2021/07/12 LONG-TERM EFFECTS OF ADOLESCENT DELTA-9-THC EXPOSURE IN SUBSTANCE ABUSE DISORDER LIABILITY ASSESSED THROUGH BEHAVIOURAL, NEUROIMAGING AND TRANSCRIPTOME STUDIES (PhD)
(Thesis) Main arguer
 Javier Orihuel Menéndez (PhD)
Universidad Nacional de Educación a Distancia, Spain
2021/03/18 NLRP3 inflammasome-driven neurodegeneration and epileptiform activity in a model of epileptogenesis in organotypic slices (MSc)
(Thesis) Main arguer
 Francisco José Gonçalves Meda (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/11/27 METHYLPHENIDATE-INDUCED ALTERATIONS IN ASTROCYTES: A COMPREHENSIVE CHARACTERIZATION (MSc)
Supervisor
 Mariana Muga (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/18 Investigation of the Blood-Brain Barrier ageing for the development of an in vitro model (MSc)
(Thesis) Main arguer
 Ana Carolina da Silva Caetano (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/06/18 Efeitos da suplementação de taurina no exercício físico (MSc)
(Thesis) Main arguer
 Gustavo Pedrosa Rocha (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/06/18 Pinning Down TRPV1: Acupuncture Analgesia (MSc)
(Thesis) Main arguer
 Ana Rita Oliveira Coelho (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/22 Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder (PhD)
Supervisor
 Vanessa Filipa Coelho Santos (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/01 The influence of gliotransmission on higher cognitive functions (PhD)
(Thesis) Main arguer
 Vanessa Alexandra Morais Sardinha (PhD)
Universidade do Minho, Portugal
2017/10/17 Role of aquaporin-4 in methamphetamine-induced blood-brain barrier dysfunction and cerebral edema formation (PhD)
Supervisor
 Ricardo Alexandre Gomes Leitão (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09/29 Permeabilidade do ácido salicílico e do seu derivado acetilado através de um modelo in vitro para a Barreira Henatoencefálica (MSc)
(Thesis) Main arguer
 Ricardo Filipe Serrano Costa (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09/18 Psychostimulant abuse and neuroinflammation: a crosstalk between glial cells and neurons (MSc)
(Thesis) Main arguer
 Joana Catarina da Silva Bravo (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/09/05 Methylenedioxypyrovalerone (MDPV) and methamphetamine (METH) play with central innate immune system: focusing on RAGE and glial cells (MSc)
(Thesis) Main arguer
 Mafalda Maria Salvador Campeão (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09/28 The neuroregenerative influence to treadmil exercise in striata from mice intoxicated with methamphetamine (MSc)
(Thesis) Main arguer
 Hugo José Fernandes de Freitas (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/06/25 Understanding the mecahanisms of acetyl-l-carnitine through neuroprotection after methamphetamine administration (PhD)
(Thesis) Main arguer
 Sílvia Patrícia Morim Fernandes (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2015/06/17 Possible role of exercise on methamphetamine dependence management (MSc)
(Thesis) Main arguer
 António Pedro Delgado Morais (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/04/01 In vivo single cell analysis reveals distinct behavior of neural stem and progenitor cells in homeostasis and regeneration in the adult brain (PhD)
(Thesis) Arguer
 Joana Santos Barbosa (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/12/15 The role of microglia in methamphetamine exposure (MSc)
(Thesis) Main arguer
 Teresa Correia Soares Canedo (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/10/10 The communication between injured bone and the hypothalamic neuropeptide y system: the role of the humoral pathway (MSc)
(Thesis) Main arguer
 João Pedro Oliveira Martins (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2014/09/15 Involvement of vascular dysfunction in the neurogenesis impairment that occurs in Alzheimer¿s disease (MSc)
(Thesis) Main arguer
 Ana Raquel Fontes (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/18 Treadmill exercise exerts an antidepressant-like effect to mice submitted to a neurotoxic methamphetamine dose (MSc)
(Thesis) Main arguer
 Ana Clara Bragada Sequeira (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/06/13 A Novel integration approach : perturbation studies in vitro using PDK1 inhibitors in glioblastoma multiforme (MSc)
(Thesis) Main arguer
 Luís Carlos Fernandes de Oliveira (Master)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2014/03/19 The effect of acupunture in seizures prevention (MSc)
(Thesis) Main arguer
 Fábio Diogo Rebelo de Almeida (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/02/24 Acetyl-L-Carnitine Neuroprotection in Mitochondrial Dysfunction (PhD)
(Thesis) Main arguer
 Lídia Alexandra dos Santos Cunha (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/12/23 Behind bilirubin neurotoxicity: discovering what¿s left at the blood-brain barrier (PhD)
(Thesis) Main arguer
 Inês Maria Simões Palmela (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/03/13 Acute methamphetamine exposure induces long-lasting depressive-like behaviour in mice (MSc)
(Thesis) Main arguer
 Carlos António Dias da Silva (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/09/05 Characterization of glycinergic transmission in an in vitro model of Epilepsy (MSc)
(Thesis) Main arguer
 Catarina Pais Gomes Luís (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012/05/18 Role of intercellular communication between endothelial and stem cells in stemness and neurogenesis : focus on the soluble factor angiopoietin-1 and direct contact via lamimim-1/a6ß1 integrin and connexin 43 as new targets for brain repair (PhD)
(Thesis) Arguer
 Alexandra Isabel Freitas Rosa (PhD)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/09/13 Protective effect of calcium dobesilate against inflammation and oxidative/nitrosative stress in the retina of a diabetic rat model (MSc)
(Thesis) Main arguer
 Paula Cristina Antunes Voabil (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/12/10 Cocaine exposure thoughout adolescence: a hormonal, neurochemical and behavioural study in the rat. (PhD)
(Thesis) Main arguer
 Cecília Juliana Moreira Alves (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/09/04 Role of neuropeptide Y in cocaine addiction: Focus on the neuropeptide Y Y5 receptor (PhD)
(Thesis) Main arguer
 Gunnar Sorensen (PhD)
Københavns Universitet, Denmark
2008/02/28 Neuroprotective and antiepileptic role of neuropeptide Y (PhD)
(Thesis) Arguer
 Sara Alves Xapelli (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2020/01/01 - Current Member of the Animal Welfare and Ethics Committee (ORBEA) of the Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra
Member
 Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/01 - Current Member of the Scientific Council of Coimbra Institute for Clinical and Biomedical Research (iCBR)
Member
 Universidade de Coimbra Faculdade de Medicina, Portugal
2018/02/01 - Current Coordinator of the research group "Neuropharmacology and Neuropsychiatry" from the Coimbra Institute for Clinical and Biomedical Research.
Coordinator
 Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09/01 - 2019/03/19 Member of the Faculty of Medicine Council
Member
 Universidade de Coimbra Faculdade de Medicina, Portugal
2012/02/01 - 2016/11/30 Coordinator of the Research Office (GAI)
Coordinator
 Universidade de Coimbra Faculdade de Medicina, Portugal
2003/03/01 - 2012/12/31 Member of the Executive Commission, former "Institute of Biomedical Research in Light and Image (IBILI)"
Member
 Universidade de Coimbra Faculdade de Medicina, Portugal

Consulting

Activity description Institution / Organization
2014/07/02 - 2014/07/02 Participation in the National Consultation for Research Priorities within the project “European Research Area Network on Illicit Drugs (ERANID)”

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/02 - Current Applied Investigation II (Investigação Aplicada II) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2014/01/01 - Current Classes to medical students (Curricular Unit - Seminars) Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2011/01/01 - Current Master Classes ("Mestrado em Investigação Biomédica" since 2011; "Mestrado em Neurociências Molecular e de Translação" since 2021; "Mestrado de Farmacologia Aplicada" since 2019 Mestrado de Investigação Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2024/02/26 - 2024/03/01 Advanced Course in Tissue Barriers in Health and Disease (Doutoramento) Universidade de Coimbra, Portugal
2023/12/13 - 2023/12/13 "Brain and the Drugs" (O Cérebro e as Drogas" - SEMANA DA CIÊNCIA UC • 2023 Semana da Ciência UC (Ensino secundário) Universidade de Coimbra, Portugal
2021/10/04 - 2021/10/04 Tests to evaluate the behaviour of rodents Doutoramento em Ciências da Saúde (Doutoramento)
2020/12/22 - 2020/12/22 Neurobiology of addiction Master in Applied Pharmacology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/09/28 - 2020/09/28 Rodent Behavioral Tests Doutoramento em Ciências da Saúde (Doutoramento)
2020/02/27 - 2020/02/27 Psychostimulants-related brain dysfunction: Methamphetamine and Methylphenidate Seminários de Investigação (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2013/02/18 - 2013/02/21 Brain and ocular diseases: How to overcome the barriers? From basic science to imaging approaches. Ciências Biomédicas (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2012/02/06 - 2012/02/10 Brain and ocular diseases: How to overcome the barriers? Ciências da Saúde (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2006/01/16 - 2006/01/20 Neuromodulation PhD Programme in Experimental Biology and Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018/01/01 - Current Graduate Women In Science (GWIS) Fellowships
Evaluator
2023/02/15 - 2023/03/30 Projetos Semente de Investigação 2023, Universidade de Coimbra
Evaluator
 Universidade de Coimbra

Banco Santander Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/07/27 Menthal Health Europe - project "Let´s talk about children" Observador
2023/04/03 Mulheres na Ciência UC (Women in Science, University of Coimbra)
2022/10/12 A neurociência e a saúde mental Jornal As Beiras
2022/06/22 “C+Neuro (Conversa + Neuro)”
2011/10 Outreach of research work about the "Impact of methamphetamine use in the brain" in several TV channels and national Newspapers (SIC Notícias; ptjornal.com; rcmpharma; Jornal de Ciência, Tecnologia e Empreendedorismo, CiênciaHoje; CiênciaPT.net; TV NET; TVI24; Diário as Beiras; Diário de Coimbra; Revista C; Jornal de Notícias)

Interview (tv / radio show)

Program Topic
2015/06/06 - 2015/06/06 Participation in TV programme (Front Line; RTP channel) about the impact of methylphenidate use entitled "My Brain" - Linha da Frente, “Cérebro meu” (episode 21, http://www.rtp.pt/play/p1764/e197515/linha-da-frente#).
2014/11/11 - 2014/11/11 TV programme (SIC News) about the effects of drugs of abuse in the brain - “Efeito das drogas no cérebro” (https://www.youtube.com/watch?v=djXIJQK7wFc).
2009 - 2009 Collaboration in the project “Põe-te a milhas das pastilhas – e-drogas” financed by Calouste Gulbenkian Foundation. Science Outreach Videos about the problematic of addiction (in PT). https://www.youtube.com/watch?v=ZdxQCqxaX0k https://www.youtube.com/watch?v=4wTbmrnUfic https://www.youtube.com/watch?v=ujpCzI-q-B8

Journal scientific committee

Journal title (ISSN) Publisher
2023/09/01 - 2023/10/02 Environmental Science: Nano
2023/03/21 - 2023/04/20 Frontiers in Drug Delivery
2021 - 2021 Brain Research Elsevier
2020/02/02 - 2020/02/21 Neurochemical Research (1573-6903) Springer-Verlag
2020/01 - 2020/01 Frontiers in Neuroscience (1662-453X) Frontiers Media SA
2020 - 2020 Journal of Alzheimer's Disease IOS Press
2020 - 2020 Scientific Reports Nature Research
2019 - 2019 Neurotoxicity Research (1476-3524) Springer-Verlag
2017 - 2017 Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2016 - 2016 Brain Research (0006-8993) Elsevier
2016 - 2016 Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2016 - 2016 Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - 2015 Ophthalmic Research (1423-0259) S. Karger AG
2014 - 2014 Frontiers in Neuroscience (1662-453X) Frontiers Media SA
2012 - 2012 Neurochemical Research (1573-6903) Springer-Verlag
2012 - 2012 Neurotoxicity Research (1476-3524) Springer-Verlag
2011 - 2011 Journal of Neuroscience Research (1097-4547) Wiley (John Wiley & Sons)
2011 - 2011 Neuropsychopharmacology (1740-634X) Springer Science and Business Media LLC
2011 - 2011 Neurotoxicity Research (1476-3524) Springer-Verlag
2011 - 2011 Psychopharmacology (1432-2072) Springer-Verlag
2008 - 2008 Journal of Neuroscience Research (1097-4547) Wiley (John Wiley & Sons)
2008 - 2008 Physiological Research (1802-9973) Institute of Physiology of the Czech Academy of Sciences
2006 - 2006 Brain Research (0006-8993) Elsevier
2005 - 2005 Current Drug Targets - CNS & Neurological Disorders (1568-007X) Bentham Science
2003 - 2003 Neurochemical Research (1573-6903) Springer-Verlag

Mentoring / Tutoring

Topic Student name
2023/01/01 - Current Supervision of Lab rotations, MSc in Biomedical Research (FMUC), MSc in Molecular and Translational Neurocience (FMUC), MSc in Cellular and Molecular Biology, (FCTUC) Many students during each year
2018/03/01 - Current Supervision of the Postdoctoral fellow - Project “BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias (CENTRO-01-0145-FEDER-000008)” Bolsa de Investigação (BID 2.3) Ricardo Alexandre Gomes Leitão
2022/02/07 - 2022/07/29 Undergraduate thesis/ Scientific traineeship - B. Sc in Biology, University of Coimbra, Portugal Catarina Neto
2022/02/07 - 2022/07/29 Undergraduate thesis/ Scientific traineeship - B. Sc in Biology, University of Coimbra, Portugal Joana Teles
2022/03/01 - 2022/03/31 Laboratory rotations (M.Sc.) - Master in Cellular and Molecular Biology Ana Olívia Fernandes
2022/03/01 - 2022/03/31 Laboratory rotations (M.Sc.) - Master in Cellular and Molecular Biology João Nuno Rodrigues
2022/02/07 - 2022/02/25 Laboratory rotations (M.Sc.) - Master in Biomedical Research Gonçalo Ferreira
2022/02/07 - 2022/02/25 Laboratory rotations (M.Sc.) - Master in Biomedical Research Laura Nóbrega
2021/10/04 - 2021/10/22 ERASMUS+, Staff mobility for training - Professor from the Medical University of Sofia, Bulgaria Ivanka Kostadinova
2021/02/15 - 2021/07/31 Undergraduate thesis/ Scientific traineeship - B. Sc in Biochemistry, University of Coimbra, Portugal Amélia Ormonde
2021/02/15 - 2021/07/31 Undergraduate thesis/ Scientific traineeship - B. Sc in Biochemistry, University of Coimbra, Portugal Beatriz Marques
2021/01/04 - 2021/01/31 Laboratory rotations (M.Sc.) - Master in Molecular and Translational Neuroscience José Carreira
2021/01/04 - 2021/01/31 Laboratory rotations (M.Sc.) - Master in Cellular and Molecular Biology Diogo Bruno
2020/02/10 - 2020/07/29 Undergraduate thesis/ Scientific traineeship - B. Sc in Biology, University of Coimbra, Portugal) Leandro Várzeas
2019/02 - 2020/07 Undergraduate thesis/ Scientific traineeship - B. Sc in Biology, University of Coimbra, Portugal) José Luís Marques
2020/03/02 - 2020/03/20 Laboratory rotations (M.Sc.) João Santos
2020/01/06 - 2020/01/24 Laboratory rotations (M.Sc.) Gabriela Ribeiro
2019/05/01 - 2019/07/31 Undergraduate thesis/ Scientific traineeship - ERASMUS student from the University of Benevento, Benevento, Italy Rosalba Vitagliano
2018/10/01 - 2019/04/01 Supervision of the Postdoctoral fellow - Project “BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias (CENTRO-01-0145-FEDER-000008)” Bolsa de Investigação (BID 2.1) Maria Helena Bica Madeira
2019/03/04 - 2019/03/29 Laboratory rotations (M.Sc.) Magda Rodrigues
2019/03/01 - 2019/03/29 Laboratory rotations (M.Sc.) Rafael Baganha
2019/01/28 - 2019/02/22 Laboratory rotations (M.Sc.) Inês Elias
2018/10 - 2019/02 Undergraduate thesis/ Scientific traineeship - B. Sc in Biology, University of Coimbra, Portugal Inês Moniz
2018/05 - 2018/07 International students and postdocs - PhD student, University of Valencia, Spain. Solanye Guerra Ojeda
2018/04/23 - 2018/05/11 Laboratory rotations (M.Sc.) João Novo
2018/03/03 - 2018/03/23 Laboratory rotations (M.Sc.) Ana Luisa Bernardo
2018/01/29 - 2018/02/23 Laboratory rotations (M.Sc.) Débora Mena
2018/01/29 - 2018/02/16 Laboratory rotations (M.Sc.) Inês Lopes
2018/01/10 - 2018/02/03 Laboratory rotations (M.Sc.) Roberta Fresia
2018/01/03 - 2018/01/22 Laboratory rotations (M.Sc.) Catarina Nascimento
2016/04 - 2016/10 International students and postdocs - PhD student from Universidade Federal do Ceará, Fortaleza, Brazil. Cristhyane Costa
2016/06/01 - 2016/06/30 Laboratory rotations (M.Sc.) Maria Inês Mendes
2016/02/29 - 2016/03/24 Laboratory rotations (PhD) Nadiya Kubasova
2015/04 - 2016/03 International students and postdocs - Postdoctoral researcher from Universidade Federal do Ceará, Fortaleza, Brazil. Luis António Alves
2016/01/04 - 2016/01/22 Laboratory rotations (M.Sc.) Rafael Carecho
2015/05 - 2015/11 International students and postdocs - PhD student from the University of Oviedo, Spain. Marta Mendez Lopez
2015/03 - 2015/06 Undergraduate thesis/ Scientific traineeship - ERASMUS student at Medical School, University of Coimbra, Portugal Giovanni Pigliapochi
2015/02 - 2015/06 Undergraduate thesis/ Scientific traineeship (B. Sc in Biochemistry, University of Coimbra, Portugal) Rute Gonçalves
2015/02 - 2015/06 Undergraduate thesis/ Scientific traineeship - B. Sc in Biochemistry, University of Coimbra, Portugal) Ana Rita Mendes
2012/04 - 2012/07 International students and postdocs - Master student from the University of Ljubljana, Slovenia. Rok Kosmina
2011/01 - 2012/05 Undergraduate thesis/ Scientific traineeship - B.Sc in Biotechnology, College of Agriculture of Coimbra, Polytechnic Institute of Coimbra, Portugal Juliana Salomé Pereira Pinto
2011/06 - 2011/07 International students and postdocs - PhD student from the University of Calabar, Nigeria, IBRO Scholarship “Young Investigator Visiting Program”. Olaitan Ruth Asuquo
2010/05 - 2010/07 Undergraduate thesis/ Scientific traineeship - B. Sc in Biomedical Sciences, University of Algarve, Portugal Ricardo Alexandre Gomes Leitão
2009/01 - 2009/07 Undergraduate thesis/ Scientific traineeship - B.Sc. Biology, University of Coimbra Tiago Morais
2009/01 - 2009/07 Undergraduate thesis/ Scientific traineeship - B.Sc. Biology, University of Coimbra Sandrine Pontes Machado
2007/09 - 2008/07 Undergraduate thesis/ Scientific traineeship - B.Sc. Biology, University of Coimbra Liliana Catarina Ferreira Trindade
2007/09 - 2008/07 Undergraduate thesis/ Scientific traineeship - Medical student. Programme "Research projects for medical students - GAI" João Gonçalo Santiago
2006/09 - 2007/07 Undergraduate thesis/ Scientific traineeship - B.Sc. Biology, University of Coimbra Tânia Sofia Cordeiro Martins
Distinctions

Award

2024 Best oral presentation at "7º Congresso Nacional de PHDA “A PHDA ao longo da vida: adolescente e adulto”, Corresponding author
Sociedade Portuguesa de Défice de Atenção, Portugal
2023 Best Oral Presentation Award - III ASPIC-ASEICA International Meeting (Impact of HER2+ brain tropic breast vancer vells in blood-brain barrier dysfunction during the premetastatic niche formation) - Co-author
2022 Best poster presentation at the 5th ASPIC International Congress (Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery) - Co-author
2018 Best oral communication "Impact of methamphetamine on the hippocampal neuropeptide Y system: Endothelial protective role"
Grupo Tecnimede, Portugal
2018 Best oral communication: "An eye on ADHD: can the retina be used as a diagnosis support tool?"
2015 Best Poster presentation at the "In4Med, Medical-Scientific meeting"
AstraZeneca Produtos Farmacêuticos Lda, Portugal
2014 Best poster presentation at the "Internacional NPY Meeting"
2013 Best Scientific Image
Universidade de Coimbra Faculdade de Medicina, Portugal
2002 Gulbenkian Programme of Investigation Stimulus, Intracellular Communication field
Fundação Calouste Gulbenkian, Portugal
2000 Best poster in the II Congress of Medical Investigation
Universidade de Coimbra Faculdade de Medicina, Portugal

Other distinction

2020 Cover of the Book "Advances in Brain Vascular Research"
Cambridge Scholars Publishing, United Kingdom
2018 Best oral presentation “Effects of high-fat and hypoproteic diets on hippocampal blood-brain barrier permeability and oxidative stress”
2011 Cover of Brain Research, Vol 1411, September 9.
2003 Honorable Mention from Pulido Valente Award, 2003 Neuroscience