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Mafalda Santos completed her master's degree in Biomedical Engineering at University of Lisbon - Instituto Superior Técnico (IST) in December 2022. During her master thesis (Feb 2022 - Dec 2022), Mafalda Santos performed research work in the areas of Tissue Engineering and Bioengineering, specifically developing cell-derived extracellular matrix loaded electrospun nanofibrous scaffolds, using decellularized extracellular matrix derived from periodontal ligament stem cells. The main aim of her master thesis was to develop and characterize electrospun scaffolds to mimic the structure, architecture and the composition of native periodontal tissue extracellular matrix, envisaging periodontal tissue engineering strategies. The work from her master thesis project was developed in the Stem Cell Research Group (SCERG) at the Institute for Bioengineering and Biosciences (iBB) of Instituto Superior Técnico Campus Taguspark. Mafalda Santos was awarded research fellows on the FCT-funded projects "DentalBioMatrix - Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues" (Mar 2023 - Nov 2023) and "NKboost: Development of a platform for the production of CAR-modified NK cells and their extracellular vesicles" (Jan 2024 - April 2024) at iBB of IST. Her research focused primarily on the development of functional hierarchical biomaterials that mimic native tissues and the assessment of their potential to support cell proliferation and differentiation. Mafalda Santos has published one original research article, two reviews and one proceeding paper in international peer-reviewed scientific journals. Her work was presented in international scientific conference meetings.
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Identification

Personal identification

Full name
Mafalda Silva Santos

Citation names

  • Santos, Mafalda
  • Santos, Mafalda S.

Author identifiers

Ciência ID
8F14-72CA-2869
ORCID iD
0000-0003-3862-4794

Email addresses

  • mafaldasantos4@tecnico.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2020/09/14 - 2022/12/07
Concluded
 Engenharia Biomédica (Mestrado)
Major in Bioengenharia Molecular e Celular, Engenharia de Tecidos e Medicina Regenerativa
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Cell-derived ECM loaded electrospun nanofibrous scaffolds for periodontal regeneration" (THESIS/DISSERTATION)
 17
2017/09/11 - 2021/07/27
Concluded
 Engenharia Biomédica (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 14
2020/09/16 - 2021/01/27
Concluded
 ERASMUS Exchange Program - Sciences de l' Ingénieur (Master)
Major in Ingenierie pour la santé
Sorbonne Université Faculté des Sciences et Ingénierie, France
2014/09 - 2017/05
Concluded
 Abitur Alemão Internacional (Ensino secundário)
Escola Alemã de Lisboa, Portugal
 19
Affiliation

Science

Category
Host institution 		Employer
2023/03/01 - Current Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal

Others

Category
Host institution 		Employer
2022/02/07 - 2022/12/07 Master Student Researcher Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal
2015/06/22 - 2015/07/03 Formação em Contexto de Trabalho Laboratorial Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Grant

Designation Funders
2024/01/15 - 2024/04/15 NKboost: Development of a platform for the production of CAR-modified NK cells and their extracellular vesicles
PTDC/EQU-EQU/3708/2021
Research Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
2023/03/01 - 2023/11/30 DentalBioMatrix - Exploiting the power of decellularized extracellular matrix to fabricate hierarchical biomimetic scaffolds to regenerate functional periodontal tissues
PTDC/BTM-MAT/3538/2020
Research Fellow
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference paper
  1. Mafalda S. Santos; Rachel Cordeiro; Carla S. Moura; Cláudia L. da Silva; Frederico Castelo Ferreira; João C. Silva; Marta S. Carvalho. "Decellularized Extracellular Matrix Polycaprolactone/Chitosan Composite Nanofibrous Scaffolds for Periodontal Tissue Engineering". 2023.
    10.3390/IOCN2023-14495
Conference poster
  1. Mafalda S. Santos; João C. Silva; Marta S. Carvalho. "Incorporating Lyophilized Extracellular Matrix in Electrospun Scaffolds for Periodontal Tissue Engineering". Paper presented in 3rd iBB Workshop, 2023.
  2. Mafalda S. Santos; João C. Silva; Marta S. Carvalho. "Nanofibrous Scaffolds Combined With Decellularized Extracellular Matrix For Periodontal Tissue Engineering". Paper presented in ETRS & SPCE-TC Joint Meeting, 2023.
  3. Mafalda S. Santos; Marta S. Carvalho; João C. Silva. "Electrospun scaffolds combined with decellularized cell-derived extracellular matrix for periodontal regeneration". Paper presented in Annual International (bio)Medical Students Meeting - Poster Session, 2023.
  4. Marta S. Carvalho; Mafalda S. Santos; Alexandra S. Bettecourt; Joaquim M.S. Cabral; Frederico C. Ferreira; Cláudia L. da Silva. "Exploiting the power of decellularized ECM for periodontal tissue regeneration". Paper presented in 2nd iBB Workshop, 2022.
Encyclopedia entry
  1. Santos, Mafalda S.; Carvalho, Marta S.; Silva, João C.. Corresponding author: Silva, João C.. "Currently Available Treatments for Periodontal Disease". In Scholarly Community Encyclopedia. MDPI, 2023. https://encyclopedia.pub/entry/42957.
    Published
Journal article
  1. Mafalda Santos; João Carlos Silva; Marta Carvalho. "Hierarchical Biomaterial Scaffolds for Periodontal Tissue Engineering: Recent Progress and Current Challenges". International Journal of Molecular Sciences (2024): https://www.mdpi.com/1422-0067/25/16/8562.
    10.3390/ijms25168562
  2. Santos, Mafalda S.; Cordeiro, Rachel; Moura, Carla S.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Silva, João C.; Carvalho, Marta S.. "Bioactive Nanofibrous Scaffolds Incorporating Decellularized Cell-Derived Extracellular Matrix for Periodontal Tissue Engineering". ACS Applied Nano Materials (2024): http://dx.doi.org/10.1021/acsanm.4c00140.
    10.1021/acsanm.4c00140
  3. Mafalda S. Santos; Alexandra B. dos Santos; Marta S. Carvalho. "New Insights in Hydrogels for Periodontal Regeneration". Journal of Functional Biomaterials (2023): https://doi.org/10.3390/jfb14110545.
    10.3390/jfb14110545
  4. Mafalda S. Santos; Marta S. Carvalho; João C. Silva. "Recent Advances on Electrospun Nanofibers for Periodontal Regeneration". Nanomaterials (2023): https://doi.org/10.3390/nano13081307.
    10.3390/nano13081307
Preprint
  1. Santos, Mafalda S.; Cordeiro, Rachel; Moura, Carla S.; Cabral, Joaquim M. S.; Ferreira, Frederico Castelo; Silva, João C.; Carvalho, Marta S.. "Cell-derived ECM loaded electrospun Polycaprolactone/Chitosan nanofibrous scaffolds for periodontal regeneration". 2023. http://dx.doi.org/10.1101/2023.03.30.534964.
    10.1101/2023.03.30.534964
Thesis / Dissertation
  1. "Cell-derived ECM loaded electrospun nanofibrous scaffolds for periodontal regeneration". Master, Universidade de Lisboa Instituto de Bioengenharia e Biociências, 2022. https://fenix.tecnico.ulisboa.pt/cursos/mebiom21/dissertacao/565303595502962.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/04/01 Electrospun scaffolds for periodontal ligament regeneration SCERG Seminar - Master Students Symposium
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/06/02 - 2022/06/02 Caixa de Pandora - Componentes Derivados de Animais O evento Caixa de Pandora consiste numa tertúlia informal acerca de questões éticas e morais mais proeminentes na área da Bioengenharia. O tema deste evento foi a utilização de componentes "xenofree" versus "animal derived" em laboratório/investigação, as suas vantagens e desvantagens. A Dra Ana Fernandes e a Dra Paola Alberte foram as convidadas e oradoras deste evento da EMBS do IEEE-IST Student Branch, direcionado a alunos interessados nos campos da Biologia e Medicina aplicados à Engenharia. (2022/06/02)
Round table (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Mentoring / Tutoring

Topic Student name
2023/11/06 - Current Culture and electrical stimulation of periodontal ligament stem cells Rúben Pires
2023/01/23 - 2023/02/03 Production of decellularized extracellular matrix derived from osteoblasts Margarida Domingues
Distinctions

Other distinction

2023 Academic Merit Diploma for the academic year 2021/2022 as a result of its excellent performance (level B) in the Mestrado em Engenharia Biomédica