Joana Medeiros Vieira Marques (8F1D-1D21-457C)

Curriculum Vitae

Joana Medeiros Vieira Marques

After my graduation in Biotechnological Engineering in 2003, I joined the Center for Neuroscience of Coimbra (CNC, Coimbra, Portugal) to develop my MSc thesis, where I characterized the signal transduction pathways involved in the yeast's response to several stresses. This raised yeasts as a basic model to study inflammatory/stress responses at the cellular level and to assist in the search/screening of new anti-inflammatory drugs (1 first author publication in J. Biol. Chem. and 2 co-author publications). In 2006, I joined J Lerma's lab (Instituto de Neurociencias, Alicante, Spain) to perform my PhD in neuroscience, where I could provide the first link between activity, i.e. glutamate, and neurocytoskeleton dynamics during neuronal development, raising kainate receptor as the key tether linking synaptic contact formation and neuronal maturation. These results were published in J. Neuroscience (first author publication awarded with Best Paper 2014 award by Portuguese Society for Neurosciences) and reviewed in Neuron. In 2013 I joined RJ Rodrigues' lab at CNC (Coimbra, Portugal) to explore the pathological role of purinergic and glutamate receptors in brain diseases. I contributed to determine that P2Y1R contributes to glutamate-induced neurodegeneration (Simões et al., 2018) and to synaptic and memory loss in Alzheimer's disease models, raising the concept that this newly identified pathway may constitute a degenerative mechanism shared by different brain diseases. This work was supported by an international grant from Alzheimer's Association (NIRG-15-361884) in which I was Co-PI. I have been also exploring the existence of hybrid P2X/GluN receptors, establishing a new receptor concept (manuscript under revision; Postdoctoral fellowship SFRH/BPD/107903/2015). I also contributed to 8 co-author publications on the physio-pathological role of purinergic signalling. I also started my transition towards my scientific independency by exploring a new line of investigation dedicated to explore brain diseases from the perspective of brain development, merging my interest/expertise in brain development (PhD) and disease (postdoc). This has been successfully accomplished, attested by the attribution of CEEC Individual 2017 (Junior level) and of my first grant as a PI (PTDC/MED-NEU/28160/2017; 238,834€). In this realm we have been exploring the role of purinergic receptors in neuronal migration during embryogenesis (Cerebral Cortex 31(12):5652) and in the synaptic remodeling in the adult brain in pathological conditions (Scientific Reports 12(1):14690). Also, I supervised 3 BSc and 2 MSc theses, and 1 PhD student, and participated in teaching in post-graduate programs.

Read full resume ↓

Identification

Personal identification

Full name: Joana Medeiros Vieira Marques
Date of birth: 1977/03/03
Gender: Female

Citation names

Marques, Joana
Joana M Marques

Author identifiers

Ciência ID: 8F1D-1D21-457C
ORCID iD: 0000-0002-7234-9477
Scopus Author Id: 55888289600

Email addresses

joanammarques@gmail.com (Professional)

Addresses

Center for Neuroscience and Cell Biology Faculdade de Medicina, Polo I, Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Professional)
Rua Nuno Tristão nº10, 3030-066, Coimbra, Coimbra, Portugal (Personal)

Websites

https://cnc.uc.pt/en/people/j-marques (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Advanced (C1)	Proficiency (C2)	Advanced (C1)	Proficiency (C2)	Proficiency (C2)
French	Elementary (A2)	Elementary (A2)	Elementary (A2)	Intermediate (B1)	Elementary (A2)

Education

	Degree	Classification
2022/12/15 Concluded	Certificado de Competências Pedagógicas (Outros) Instituto do Emprego e Formação Profissional, Portugal
2013/10/31 Concluded	PhD in Biology (Doutoramento) Major in Cell Biology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Role of kainate receptors in neuronal development." (THESIS/DISSERTATION)	Aprovada com Distinção e Louvor por Unanimidade
2006/11/02 Concluded	MSc in Celular and Molecular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Involvement of Hog1 protein in the Saccharomyces cerevisiae response to lipopolysaccharide." (THESIS/DISSERTATION)	Very Good
2003/02/19 Concluded	Biotechnology Engineering (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal "Metabolic alterations in yeast apoptosis." (THESIS/DISSERTATION)	14

Affiliation

Others

	Category Host institution	Employer
2019/04/01 - Current	CEECIND 2017 Junior Investigator (01879)	FCT- Fundação para a Ciência e a Tecnologia, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/07/05 - 2021/12/31	Investigator - Project Principal Investigator - POCI-01-0145-FEDER-028160- "A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis"	FCT- Fundação para a Ciência e a Tecnologia, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06 - 2018/06	Postdoctoral fellowship	FCT- Fundação para a Ciência e a Tecnologia, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/11 - 2016/05	Project Investigator	Alzheimer's Association, United States
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05 - 2015/08	Postdoctoral fellowship	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/05 - 2011/12	PhD fellowship	FCT- Fundação para a Ciência e a Tecnologia, Portugal
	Instituto de Neurociencias de Alicante Laboratorio Synaptic Physiology, Spain
2006/08 - 2007/05	Project Investigator	Consejo Superior de Investigaciones Científicas, Spain
	Instituto de Neurociencias de Alicante CSIC-UMH, Spain
2003 - 2006	Project Investigator	Fundação para a Ciência e a Tecnologia, I.P., Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal

Projects

Grant

	Designation	Funders
2019/04/01 - Current	CEECIND2017-A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis. 01879 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	FCT- Fundação para a Ciência e a Tecnologia Ongoing
2023/03 - 2024/08	Role of adenosine P1 receptors in the control of cortical neurons migration - the first unilateral mechanism in brain development? 2022.03263.PTDC Co-Principal Investigator (Co-PI)	Fundação para a Ciência e Tecnologia Ongoing
2018/07/05 - 2021/12/31	A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis PTDC/MED-NEU/28160/2017 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	FCT- Fundação para a Ciência e a Tecnologia Concluded
2018/07 - 2021/12	Os receptores A2A para a adenosina controlam a formação de axónios durante o desenvolvimento neuronal: novas estratégias para prevenir a epileptogénese. Provided by PTCRIS: PTDC/MED-NEU/28160/2017	Fundação para a Ciência e a Tecnologia, I.P.
2016/01 - 2018/06	Hybrid ionotropic receptors: a new receptor concept PTDC/NEU-NMC/3567/2014 Provided by PTCRIS: SFRH/BPD/107903/2015 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	FCT- Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia, I.P. Concluded
2015/01 - 2017/01	P2Y1 Receptor-CRMP2 Control Synaptic Loss and Memory Impairment in Early Alzheimer’s Disease grant.alz6e384926 NIRG-15-361884 Co-Principal Investigator (Co-PI) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Alzheimer's Association Concluded
2011 - 2016	Role of kainate receptors in health and disease BFU2011-24084 Researcher Instituto de Neurociencias de Alicante, Spain	España Ministerio de Ciencia e Innovación Concluded
2013/03 - 2014/04	Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena. 126861 Provided by PTCRIS: 126861 FCT-EXPL/NEU-NMC/0671/2012 FCT-EXPL/NEU-NMC/0671/2012 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2013/03 - 2014/04	Papel dos receptores P2Y1 na polaridade neuronial e no crescimento axonial: implicações na proliferação das fibras musgosas na epilepsia. Provided by PTCRIS: EXPL/NEU-NMC/0671/2012	Fundação para a Ciência e a Tecnologia, I.P.
2007/06 - 2011/12	Role of kainate receptors in neuronal maturation, navigation and synaptogenesis SFRH / BD / 27517 / 2006 PhD Student Fellow Instituto de Neurociencias de Alicante CSIC-UMH, Spain	FCT- Fundação para a Ciência e a Tecnologia Concluded
2007/06 - 2011/11	ROLE OF KAINATE RECEPTORS IN NEURON MATURATION, NAVIGATION AND SYNAPTOGENESIS Provided by PTCRIS: SFRH/BD/27517/2006	Fundação para a Ciência e a Tecnologia, I.P.

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019 - 2025	A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis. CEECIND2017	Fundação para a Ciência e a Tecnologia
2018/07/06 - 2022/07/04	iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics PTDC/BTM-TEC/29621/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Varela Amaral, Sara. A Saúde no saber. Coimbra, Portugal: Imprensa da Universidade de Coimbra. 2023. Published
Conference poster	Gregório Figueira, Ana Sofia; Partidário, Matilde; Xu, Xinli; Sara B. Fernandes; Cunha, Rodrigo A.; Joana M Marques; Rodrigues, Ricardo J.. "Involvement of CRMP2 in P2Y1R-driven increase in axonal NMDAR-mediated Ca2+-entry in neurotoxic conditions". Paper presented in 11th IBRO World Congress, 2023. Marques, Joana; Rodrigues, Ricardo J.. "Cortical interneurons migration entails motogenic action of P2Y1 receptor and guidance by P2X1 receptor.". Paper presented in SPN 2021 meeting, 2021. Joana M Marques. "Status epilepticus-induced hippocampal mossy fiber sprouting requires adenosine A2A receptor.". Paper presented in SPN 2021 meeting, 2021. Joana M Marques; Ricardo Jorge de Alves Rodrigues. "Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis.". Paper presented in FENS 2020 Virtual Forum, 2020. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; Rocha, JMM; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Paper presented in SPN2019 meeting, 2019. Xu, Xinli; Alçada-Morais, S; Rocha, JMM; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ; Joana M Marques. "Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis". Paper presented in SPN2019 meeting, Lisbon, Portugal, 2019. Alçada-Morais, S; Rocha, JMM; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; Joana M Marques; et al. "Cortical Neuron migration entails A2A receptor-driven neuronal polarization and axon formation". Paper presented in SPN2019 meeting, Lisbon, Portugal, 2019. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017. https://doi.org/10.1111/jnc.14094 Rodrigues, RJ; Alçada-Morais, S; Leyva-Diaz, E; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; et al. "Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017. Joana M Marques; Canas, PM; Porciúncula, LO; Queiroz, F; Xu, Xinli; Silva, CG; Fernandes, Beatriz; et al. "P2Y1 receptor is required for Aß-induced synaptic loss, plasticity deficits and memory impairment". Paper presented in ISN-ESN MEETING 2017, Paris, France, 2017. https://doi.org/10.1111/jnc.14094 Alçada-Morais, S; Xu, Xinli; Joana M Marques; Gonçalves, Nélio; Ferreira, Sofia; Beleza, RO; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control axon formation during neuronal development: implications to neuronal migration and epileptogenesis". Paper presented in 7th ISN Special Conference of Neurochemistry, Coimbra, Portugal, 2016. Ferreira, Sofia; Marques, JM; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons". Paper presented in 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016. 10.1109/cca.2012.6402731 Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Xu, Xinli; Andres, B; et al. "Adenosine A2A receptors control cortical neuronal migration". Paper presented in 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016. Pinheiro, BS; Lemos, C; Joana M Marques; Neutzling-Kaufmann, F; da Silva-Santos, CS; Rodrigues, RJ; Cunha, RA; Köfalvi, A. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the metabolic state-dependent activation of the nucleus accumbens by insulin". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.1259/conf-pukrc.2017.poster-abs Xu, Xinli; Alçada-Morais, S; Joana M Marques; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors induce the formation of abnormal secondary axons in rat hippocampal neurons: a new target to arrest epileptogenesis". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.1259/conf-pukrc.2017.poster-abs Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control cortical neurons migration". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.1259/conf-pukrc.2017.poster-abs Rodrigues, RJ; Aller, MI; Palacios, J; Joana M Marques; Cunha, RA; Lerma, J. "P2X2/GluN2B hybrid receptors: a new concept of receptor". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.4271/2001-24-0033 Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor promotes the migration of medial ganglionic eminence-derived interneurons". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Aller, MI; Lerma, J. "Kainate receptors induce axon formation and outgrowth in mice hippocampal neurons". Paper presented in XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015. 10.1259/conf-pukrc.2017.poster-abs Simões, AP; Silva, CG; Pochmann, D.; Joana M Marques; Oses, JP; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Neuronal P2Y1 receptors are required for NMDAR-induced, calpain-mediated synaptic loss and neuronal death". Paper presented in 9th FENS Forum of Neuroscience, Milan, Italy, 2014. 10.1259/conf-pukrc.2017.poster-abs Beleza, RO; Ferreira, Sofia; Alçada-Morais, S; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Purinergic signaling is essential for proper neuronal polarization". Paper presented in XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013. 10.1259/conf-pukrc.2017.poster-abs Porciúncula, LO; Silva, CG; Canas, PM; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Paper presented in XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013. 10.1259/conf-pukrc.2017.poster-abs Rodrigues, RJ; Porciúncula, LO; Canas, PM; Silva, CG; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Paper presented in 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Valbuena, S; Rozas, JL; Selak, S; Marin, P; Aller, MI; Lerma, J. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development". Paper presented in 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in XII meeting of the Portuguese Neuroscience Society, Lisbon, Portugal, 2011. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in 8th world congress of International Brain Research Organization, Florence, Italy, 2011. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Paper presented in XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011. Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity through the control of CRMP2 function". Paper presented in XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011. 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2146 Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Aller, MI; Lerma, J. "Bidirectional modulatory role of kainate receptors on neuronal maturation". Paper presented in 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011. 10.1259/conf-pukrc.2017.poster-abs Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity in mice hippocampal neurons through the control of CRMP2 function". Paper presented in 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011. 10.1259/conf-pukrc.2017.poster-abs Paulo, C; Joana M Marques; Mourão, C; Nogueira, C; Alves, M; Meliço-Silvestre, A; Alves, AF; Quintas, C; Gonçalves, Teresa. "Understanding yeast infections epidemiology: a revision of the diagnosis/identification procedures applied to the Portuguese population". Paper presented in 3rd Trends in Medical Mycology, Turin, Italy, 2007. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Rodrigues, RJ; Gonçalves, Teresa. "Characterization of S. cerevisiae Hog1 protein activation upon bacterial LPS-exposure". Paper presented in XXIInd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovaquia, 2005. Gonçalves, Teresa; Oliveira, AP; Joana M Marques; McCance, D; de Magalhães-Sant'Ana, AC; Santos, P.; Regateiro, F; Castro, IM. "Saccharomyces cerevisiae stress resistance patterns upon HPV16.E6 expression". Paper presented in 25th International Specialized Symposium on Yeasts, Oropesa del Mar, Spain, 2005. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Gonçalves, Teresa. "Functional Characterization of Hog1 p response upon treatment with p38 animal cell protein activators". Paper presented in 23rd International Specialised Symposium on Yeasts, Budapest, Hungary, 2003. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Paper presented in III Congresso de Investigação em Medicina, Coimbra, Portugal, 2002. 10.1259/conf-pukrc.2017.poster-abs Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Paper presented in XIII Congresso Nacional de Bioquímica, Lisbon, Portugal, 2002. 10.1259/conf-pukrc.2017.poster-abs
Journal article	Ricardo J. Rodrigues; Joana M. Marques; Attila Köfalvi. "Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence". Cells (2024): https://doi.org/10.3390/cells13221875. 10.3390/cells13221875 Ricardo J. Rodrigues; Ana S. Figueira; Joana M. Marques. "P2Y1 Receptor as a Catalyst of Brain Neurodegeneration". NeuroSci (2022): https://doi.org/10.3390/neurosci3040043. 10.3390/neurosci3040043 Xinli Xu; Rui O. Beleza; Francisco Q. Gonçalves; Sergio Valbuena; Sofia Alçada-Morais; Nélio Gonçalves; Joana Magalhães; et al. "Adenosine A2A receptors control synaptic remodeling in the adult brain". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18884-4. 10.1038/s41598-022-18884-4 Alçada-Morais, Sofia; Gonçalves, Nélio; Moreno-Juan, Verónica; Andres, Belén; Ferreira, Sofia; Marques, Joana M; Magalhães, Joana; et al. "Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation". Cerebral Cortex 31 12 (2021): 5652-5663. http://dx.doi.org/10.1093/cercor/bhab188. 10.1093/cercor/bhab188 Joana M Marques. "Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders". Journal of Caffeine and Adenosine Research (2019): http://dx.doi.org/10.1089/caff.2019.0010. 10.1089/caff.2019.0010 Joana M Marques. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001. Published • 10.1016/j.semcdb.2018.12.001 Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death and Disease 9 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS. 10.1038/s41419-018-0351-1 Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin". Brain Research Bulletin 124 (2016): 222-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS. 10.1016/j.brainresbull.2016.05.009 Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A.. "Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus". Neuropharmacology 105 (2016): 241-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS. 10.1016/j.neuropharm.2016.01.022 Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al. "High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus". Neuroscience 315 (2016): 196-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS. 10.1016/j.neuroscience.2015.12.018 Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Marques, J.M.; Rodrigues, R.J.; Cunha, R.A.; Rial, D.; Köfalvi, A.. "Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS. 10.1007/s11302-015-9474-3 Ferreira, S.G.; Gonc¸alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS. 10.1111/bph.12970 Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al. "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience 41 7 (2015): 876-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS. 10.1111/ejn.12851 Lerma, J.; Marques, J.M.. "Kainate receptors in health and disease". Neuron 80 2 (2013): 292-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885732604&partnerID=MN8TOARS. 10.1016/j.neuron.2013.09.045 Marques, J.M.; Rodrigues, R.J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J.. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation". Journal of Neuroscience 33 46 (2013): 18298-18310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS. 10.1523/JNEUROSCI.3136-13.2013 Paulo, C.; Mourão, C.; Veiga, P.M.; Marques, J.M.; Rocha, G.; Alves, A.F.; Querol, A.; et al. "Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: Spectrum and revision of the identification procedures". Medical Mycology 47 8 (2009): 836-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-73649102062&partnerID=MN8TOARS. 10.3109/13693780802709081 Marques, J.M.; Rodrigues, R.J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T.. "Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin". Journal of Biological Chemistry 281 34 (2006): 24687-24694. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS. 10.1074/jbc.M603753200 Pinto-De-Oliveira, A.; McCance, D.; De Magalhães-Sant'Ana, A.C.; Marques, J.M.; Gonçalves, T.. "Expression of HPV16 E6 oncoprotein increases resistance to several stress conditions in Saccharomyces cerevisiae". FEMS Yeast Research 5 8 (2005): 777-787. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644383654&partnerID=MN8TOARS. 10.1016/j.femsyr.2005.02.002

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019/10/18	Purinergic receptors control neuronal migration during corticogenesis	Sinal Meeting (Olhão, Portugal)
2019/09/05	Cortical principal neurons migration entails A2AR-driven neuronal polarization and axon formation	(Santiago de Compostela, Spain)
2017	Neuronal migration: a critical journey for a healthy brain.	XLVI Conferências de Genética Doutor Jacinto Magalhães – Neurogenética Pediátrica, Porto, Portugal
2016	Role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons	XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016	Adenosine A2a receptors control cortical neurons migration	XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016	P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons	Brain Without Borders meeting, Coimbra, Portugal
2016	Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation	XV meeting SPN 2017, Minho, Portugal
2014	Adenosine A2A receptors influence the establishment of neuronal polarity of rat hippocampal neurons	XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014	The bidirectional modulation of axonal outgrowth of rat hippocampal neurons by P2 receptors should involve a differential regulation of CRMP2 protein	XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014	P2Y1R is required for Aß-induced synaptic and memory loss most likely by contributing to the phosphorylation of CRMP2	XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2013	CRMP2 thethers kainate receptor activity to cytoskeleton dynamics during development	XLIII annual meeting of Portuguese Society for Pharmacology, Porto, Portugal
2013	CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development	XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal
2013	P2Y1 receptor is involved in Abeta-induced synaptic and memory loss	27th Meeting of the Grupo de Estudos do Envelhecimento Cerebral e Demência, Coimbra, Portugal
2013	CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development	IBMC, Porto, Portugal

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/03 - 2019/07	Role of P2Y1R in the regulation of NMDARS in an heterologous expression system. Co-supervisor of Diana Filipa Ribeiro e Silva Maciel Lourenço	Biologia (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03 - 2019/07	Optimization of 3D medial ganglionic eminence explant cultures for evaluation of interneuron migration. Supervisor of Matilde Maria Cabral Neves Afonso	Biologia (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019	Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth Supervisor of João Miguel Miranda da Rocha	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/02 - 2018/07	Characterization of the Abeta-1-42-induced modification in the phosphorylation of CRMP2 in mice hippocampal neurons. Supervisor of Sara Patrícia Morais de oliveira Jorge Dias	Bioquímica (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/03 - 2018/02	Characterization of Abeta-induced P2Y1 receptor-mediated phosphylation of CRMP2 Supervisor of Valentina Ruggiero	Science and Genetic Technologies (Master) Università degli Studi del Sannio, Italy
2015/03 - 2015/12	Characterization of glutamate-induced modifications in CRMP2 protein in rat hippocampal neurons Supervisor of José Alexandre Garcia Marinho da Silva	Biotecnologia (Degree) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2022/02 - Current	Dia Internacional das Mulheres e Raparigas na Ciência 2022 // International day Women in Science Seminar
2016/04 - Current	Category C for design and coordination of projects involving animal handling and experimentation by Direcção Geral de Alimentação Veterinária, Ministério da Agricultura e Veterinária, Portugal
2019/03 - 2019/03	Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2017/11 - 2017/11	Science & Technology week promoted by the science communication office of CNC- activities in “2º Jardim-Escola João de Deus de Coimbra
2017/03 - 2017/03	Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2016/03 - 2016/03	Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra” and in “2º Jardim-Escola João de Deus de Coimbra
2015/03 - 2015/03	Brain Awareness Week promoted by the science communication office of CNC- activities in “Forum Coimbra
2015/03 - 2015/03	Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra
2014/03 - 2014/03	Brain Awareness Week promoted by the science communication office of CNC- seminar in “Escola Profissional de Ourém
2014/03 - 2014/03	Brain Awareness Week promoted by the science communication office of CNC- activities with students in “2º Jardim-Escola João de Deus de Coimbra
2013/03 - 2013/03	Brain Awareness Week promoted by the science communication office of CNC – Seminar in “Escola Secundária de Pombal
2007/12 - 2007/12	Category B for laboratory animal handling and experimentation by Conselleria d’Agricultura, Pesca I Alimentació de la Generalitat Valenciana (2007/CAE/B/0002), Spain

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2013/07/01 - 2013/07/05	Integrins, rhoGTPases and cytoskeleton, GABBA-PhD program 2013 course	GABBA-PhD program 2013 (Doutoramento)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2021/06/16	A Saúde no Saber- Crónica Ilustrada Illustrated Chronicle - Brain development	Jornal Público

Interview (tv / radio show)

	Program	Topic
2018/07/15 - 2018/07/28	EUG2018 (European University Games 2018)	Physical exercise and Brain Development

Distinctions

Award

2024	Innovate Competition Award (basic research) AstraZeneca Foundation, Belgium
2014	Best Paper in Cellular and Molecular Neurobiology 2014

Other distinction

2013	Neuron - Featured Article
2011	IBRO - Travel Grant
2011	Portuguese Neuroscience Society - Travel Grant
2005	International Conference on Yeast Genetics and Molecular Biology - Grant