Tiago Alexandre Henrique Fonseca (8F1D-1D48-8551)

Curriculum Vitae

I am a Biomedical Engineer with a diverse educational background and relevant work experience. My journey began at Universidade de Lisboa, where I pursued a Bachelor's degree in Health Sciences (2016-2019), achieving an average classification of fifteen points out of twenty. Throughout my time there, I had the opportunity to attend various esteemed colleges, including Faculdade de Medicina, Faculdade de Ciências, and Faculdade de Farmácia. This broad exposure helped me acquire a solid foundation in the field of health and medicine. Driven by my passion for improving healthcare and addressing the complex challenges facing the medical field, I pursued a Master's in Biomedical Engineering (2020-2022), at Instituto Superior de Engenharia de Lisboa (ISEL), to gain the technical skills and knowledge needed to design and develop cutting-edge medical technologies that have the potential to transform patient care. During my studies, I was able to maintain a part-time job from 2018-2021 while also securing a 4-month paid-internship at Sociedade Avanço (2020) in the area of radiation/radiotherapy equipment maintenance. In recognition of my academic achievements, I was granted the excellence merit award by Direção Geral do Ensino Superior (DGES) in 2021. My academic work continued as I embarked on my thesis at the Laboratory of Engineering and Health in ISEL, working on the project PREMO (DSAIPA/DS/0117/2020), where I focused on the field of metabolomics. My objective was to establish a biomarker that may predict a patient's outcome in a hospital critical care unit using blood serum. I successfully completed this work with a final grade of nineteen points out of twenty. I graduated with an overall average classification of seventeen points out of twenty. Currently, I am continuing my research journey as a fellow researcher at the same laboratory where I completed my thesis, and I am a PhD student in the Biomedicine PhD program at the NOVA Medical School from Universidade NOVA de Lisboa. My Master thesis' work has been published and presented on various journals and congresses, respectively, and I intend, along with my colleagues and mentors, to continue our work on the PhD thesis.

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Identification

Personal identification

Full name: Tiago Alexandre Henrique Fonseca

Citation names

Tiago AH Fonseca

Author identifiers

Ciência ID: 8F1D-1D48-8551
ORCID iD: 0000-0003-0741-2211

Knowledge fields

Medical and Health Sciences - Medical Biotechnology
Engineering and Technology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)	Upper intermediate (B2)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)

Education

	Degree	Classification
2023/09 - 2027 Ongoing	Biomedicine (Doutoramento) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2019/09 - 2022/07/22 Concluded	Biomedical Enginnering (Mestrado) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal "Biomarkers Discovery For Prognosis of COVID-19 Based on Metabolomics" (THESIS/DISSERTATION)	17
2016/09 - 2019/06/26 Concluded	Health Sciences (Licenciatura) Universidade de Lisboa, Portugal Universidade de Lisboa Faculdade de Medicina, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal Universidade de Lisboa Faculdade de Medicina Dentária, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal Universidade de Lisboa Faculdade de Psicologia, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2022/03/01 - 2023/09	Contracted Researcher (Research)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal (...)

Others

	Category Host institution	Employer
2023/03 - Current	Member	Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal

2020/05 - 2020/08	Paid Internship	Sociedade Avanço, Unipessoal, Lda, Portugal
	Sociedade Avanço, Unipessoal, Lda, Portugal

Projects

Grant

	Designation	Funders
2022/03 - Current	Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine DSAIPA/DS/0117/2020 Research Fellow Centro Hospitalar de Lisboa Central EPE, Portugal Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/12/21 - 2022/02	Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine DSAIPA/DS/0117/2020 Researcher Centro Hospitalar de Lisboa Central EPE, Portugal Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia

Outputs

Publications

Conference abstract	Tiago AH Fonseca; Von Rekowski, Cristiana; Araújo, Rúben; Bento, Luis; Cecília Calado. "Metabolome profile of critically ill patients regarding invasive mechanical ventilation". Paper presented in 4th CHRC Annual Summit, Évora, 2024. Accepted Araújo, Rúben; Luís Ramalhete; Tiago AH Fonseca; Von Rekowski, Cristiana; Bento, Luis; Cecília Calado. Corresponding author: Araújo, Rúben. "Fungal and Bacterial Infections Discrimination in ICU Patients based on serum molecular fingerprint". Paper presented in 4th CHRC Annual Summit, Évora, 2024. Accepted Tiago AH Fonseca; Von Rekowski, Cristiana; Araújo, Rúben; Bento, Luis; Cecília Calado. Corresponding author: Tiago AH Fonseca. "Impact Of Serum Metabolome Isolation Process On Models’ Prediction Of Critically Ill Patients’ Mortality". Paper presented in International Conference on Advanced Vibrational Spectroscopy 2023, Kraków, 2023. Published Araújo, Rúben; Tiago AH Fonseca; Von Rekowski, Cristiana; Bento, Luis; Cecília Calado. Corresponding author: Araújo, Rúben. "Impact of COVID-19 on critically ill patients' -mortality prediction models based on serum FTIR-spectra". Paper presented in International Conference on Advanced Vibrational Spectroscopy 2023, Kraków, 2023. Published
Conference paper	Tiago AH Fonseca; Von Rekowski, Cristiana P.; Araújo, Rúben; M. Conceição Oliveira; Bento, Luis; Justino, Gonçalo C.; Cecília Calado. Corresponding author: Tiago AH Fonseca. "Predicting Critically Ill Patients Outcome in the ICU using UHPLC-HRMS Data". Paper presented in 3rd International Conference on Challenges in Engineering, Medical, Economics and Education: Research & Solutions (CEMEERS-24a), Porto, 2024. Published • 10.17758/eirai20.f0324111 Araújo, Rúben; Luís Ramalhete; Tiago AH Fonseca; Von Rekowski, Cristiana; Bento, Luis; Cecília Calado. Corresponding author: Araújo, Rúben. "Streamlining Bacterial Infection Diagnosis: Rapid Gram Classification Using FTIR Spectroscopy". Paper presented in CHEMPOR 2023, Bragança, 2023. Von Rekowski, Cristiana; Fonseca, Tiago; Araújo, Rúben; Calado, Cecília; Bento, Luís; Pinto, Iola. "Laboratory biomarkers associated to death in the first three COVID-19 waves in Portugal". Paper presented in 7th IEEE Portuguese Meeting on Bioengineering (ENBENG 2023), 2023. 10.1109/enbeng58165.2023.10175345 Rúben Araújo; Luís Ramalhete; Tiago Fonseca; Cristiana Von Rekowski; Luís Bento; Cecília R.C. Calado. "Alternative Serum Biomarkers of Bacteraemia for Intensive Care Unit Patients". 2023. 10.1109/ENBENG58165.2023.10175340 Tiago AH Fonseca; Oliveira, M. Conceiçäo; Araújo, Rúben; Bento, Luís; Von Rekowski, Cristiana; Justino, Gonçalo C.; Calado, Cecília R.C.. "Comparison of Analytical Methods Of Serum Untargeted Metabolomics". 2023. 10.1109/enbeng58165.2023.10175339
Journal article	Ana Viegas; Rúben Araújo; Luís Ramalhete; Cristiana Von Rekowski; Tiago A. H. Fonseca; Luís Bento; Cecília R. C. Calado. "Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting". Metabolites (2024): https://doi.org/10.3390/metabo14060301. 10.3390/metabo14060301 Araújo, Rúben; Luís Ramalhete; Ana Viegas; Von Rekowski, Cristiana P.; Tiago AH Fonseca; Cecília R.C. Calado; Bento, Luis. Corresponding author: Araújo, Rúben. "Simplifying Data Analysis in Biomedical Research: An Automated, User-Friendly Tool". Methods and Protocols (2024): In press Tiago AH Fonseca; Von Rekowski, Cristiana P.; Araújo, Rúben; M. Conceição Oliveira; Gonçalo C. Justino; Luís Bento; Cecília R.C. Calado. Corresponding author: Tiago AH Fonseca. "Comparison of Two Metabolomics-Platforms to Discover Biomarkers in Critically Ill Patients from Serum Analysis". Biomedicines (2024): Under revision Von Rekowski, Cristiana P.; Tiago AH Fonseca; Araújo, Rúben; Ana Martins; M. Conceição Oliveira; Gonçalo C. Justino; Bento, Luis; Cecília Calado. Corresponding author: Von Rekowski, Cristiana P.. "Predictive models of patient severity in intensive care units based on serum cytokine profiles". Journal of Proteome Research (2024): Under revision Rúben Araújo; Luís Ramalhete; Ana Viegas; Cristiana P. Von Rekowski; Tiago A. H. Fonseca; Cecília R. C. Calado; Luís Bento. "Simplifying Data Analysis in Biomedical Research: An Automated, User-Friendly Tool". Methods and Protocols (2024): https://doi.org/10.3390/mps7030036. 10.3390/mps7030036 Von Rekowski, Cristiana P.; Fonseca, Tiago A. H.; Araújo, Rúben; Brás-Geraldes, Carlos; Calado, Cecília R. C.; Bento, Luís; Pinto, Iola. "The Characteristics and Laboratory Findings of SARS-CoV-2 Infected Patients during the First Three COVID-19 Waves in Portugal: A Retrospective Single-Center Study". Medicina 60 1 (2023): 59. http://dx.doi.org/10.3390/medicina60010059. 10.3390/medicina60010059 Tiago AH Fonseca; Cristiana P. Von Rekowski; Rúben Araújo; M. Conceição Oliveira; Gonçalo C. Justino; Luís Bento; Cecília R. C. Calado. "The Impact of the Serum Extraction Protocol on Metabolomic Profiling Using UPLC-MS/MS and FTIR Spectroscopy". ACS Omega (2023): https://doi.org/10.1021/acsomega.3c01370. Open access • Published • 10.1021/acsomega.3c01370 Araújo, Rúben; Bento, Luis; Fonseca, Tiago; Von Rekowski, Cristiana; da Cunha, Bernardo Ribeiro; Cecília Calado. Corresponding author: Araújo, Rúben. "Infection Biomarkers Based on Metabolomics". Metabolites 12 2 (2022): 92. http://dx.doi.org/10.3390/metabo12020092.
Preprint	Caldeira, Viviana; N’Dembo, Luana; Araújo, Rúben; Von Rekowski, Cristiana; Tiago AH Fonseca; Sampaio, Pedro N.S.; Calado, Cecília. "A new methodology for a rapid and high-throughput comparison of molecular profiles and biological activity of phytoextracts". 2023. http://dx.doi.org/10.22541/au.169219626.69788796/v1. 10.22541/au.169219626.69788796/v1

Activities

Consulting

	Activity description	Institution / Organization
2021 - 2022	Support in supervising the thesis of Tiago Domingues Alexandre, in “Discovery of infection biomarkers based on metabolomics”, MSc Thesis in Biomedical Engineering, ISEL & ESTeSL, IPL. 2022.	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2021 - 2022	Support in supervising the thesis of Raquel Inácio, in “Características metabolómicas de Staphylococcus aureus resistentes a meticilina”, MSc Thesis in Biomedical Engineering, ISEL & ESTeSL, IPL. In collaboration with ESTeSL. 2022	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2021 - 2022	Support in supervising the thesis of Ana Luisa Estrela da Fonseca Lopes Monteiro, in “Evaluate the performamce of a portable near infrared spectrophotometer for diesel/ biodiesel content monitoring”, MSc in Biological Engineering, Instituto Superior Técnico, Universidade de Lisboa. 2022	Universidade de Lisboa Instituto Superior Técnico, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023 - 2024	Assisted in Laboratory Instruction for 'Cell and Tissue Engineering' in the MSc Biomedical Engineering Course at ISEL & ESTeSL: 2023/2024: Conducted three 4-hour lessons on 'Histological Analysis of Human Organ Tissues'."	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022 - 2023	Monitor in laboratory classes at the curricular unit of Anatomophisiology, in "Optic microscopic analysis of diverse human tissues"	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2022 - 2023	Monitor in laboratory classes at the curricular unit of Advanced Medical Therapies, in "Implementation of high throughput analysis techniques in metabolomics"	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2022 - 2023	Monitor in laboratory classes at the curricular unit of Cell and Tissue engineering, in "Basic procedures in animal cell culture", "Counting and viability assay of human leukocytes"	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2022 - 2023	Contributed to the development and teaching in the Gene Therapy and Pharmacogenomics Unit of the MSc Biomedical Engineering Course at ISEL&ESTeSL: 2023/24: Conducted two 4-hour lessons on 'Analysis of Infrared Spectra of Human Sera for Medical Diagnosis', focusing on optimizing MIR spectra acquisition through serum dilution evaluation, sample dehydration methods, and data analysis."	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022 - 2023	Gene Therapy and Pharmacogenomics, MSc course in Biomedical Engineering 2022/23: Conducted two 4-hour lessons on the "Impact of High-Throughput Methods on Method Accuracy and Precision," which included implementing protocols for protein analysis. One method involved macro-volume (1 mL) analysis with single-sample processing, while the other utilized micro-volumes (200 µL) in a 96-well plate with an automatic reading system, followed by a comparison of the two methods.	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022 - 2023	Support in laboratory classes in Human Physiology for the Biomedical Engineering bachelor.	Engenharia Biomédica (Licenciatura)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2021 - 2022	Monitor in laboratory classes at the curricular unit of Regenerative Medicine, in "Basic procedures in animal cell culture", "Isolation of mononuclear cells from whole blood".	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2021 - 2022	Monitor in laboratory classes at the curricular unit of Advanced Medical Therapies, in "Implementation of highthroughput analysis techniques in metabolomics"	Engenharia Biomédica (Mestrado)	Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal

Distinctions

Award

2022	Bolsas de Estudo por Mérito Referentes ao Aproveitamento Obtido no Ano Letivo 2020/2021 Direção-Geral de Ensino Superior (DGES), Portugal